MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

MELAS Syndrome

(UMLS:C0162671)

Definition:: A mitochondrial disorder characterized by focal or generalized seizures, episodes of transient or persistent neurologic dysfunction resembling strokes, and ragged-red fibers on muscle biopsy. Affected individuals tend to be normal at birth through early childhood, then experience growth failure, episodic vomiting, and recurrent cerebral insults resulting in visual loss and hemiparesis. The cortical lesions tend to occur in the parietal and occipital lobes and are not associated with vascular occlusion. VASCULAR HEADACHE is frequently associated and the disorder tends to be familial. (From Joynt, Clinical Neurology, 1992, Ch56, p117)
UMLS ID:: C0162671
MeSH ID:: D017241

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.651.460.620.520

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.163.100.535|C10.228.140.300.275.500|C10.668.491.500.500.500

Classification 3:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.253.329.500

Classification 4:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.565.189.535

Classification 5:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.132.100.535|C18.452.648.189.535|C18.452.660.560.620.520

Synonym(s)

MELAS Syndrome

Juvenile myopathy, encephalopathy, lactic acidosis AND stroke

Juvenile myopathy, encephalopathy, lactic acidosis and stroke

MELAS

MELAS - Mitochondrial encephalopathy, lactic acidosis and stroke-like episodes

MELAS - Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes

MELAS syndrome

MITOCHONDRIAL MYOPATHY, ENCEPHALOPATHY, LACTIC ACIDOSIS, AND STROKE-LIKE EPISODES

Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke

10.

Mitochondrial encephalopathy, lactic acidosis and stroke-like episodes

11.

Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes

12.

mela

13.

mela syndrome

14.

melas

15.

melas syndrome

16.

mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS)

17.

syndrome melas

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Metformin	FAERS: 4		US FAERS
2	Valproic Acid	FAERS: 4	9243242	CTD US FAERS
3	Valproic Acid	FAERS: 3		US FAERS
4	Voriconazole	FAERS: 3		US FAERS
5	rofecoxib	FAERS: 3		US FAERS
6	Anastrozole	FAERS: 2		OFFSIDES US FAERS
7	Atorvastatin	FAERS: 2		US FAERS
8	Carbamazepine	FAERS: 2		US FAERS
9	Levetiracetam	FAERS: 1		US FAERS
10	Lovastatin	FAERS: 1		US FAERS
11	Simvastatin	FAERS: 1		US FAERS
12	Carnitine			OFFSIDES
13	Dexamethasone		2739598	CTD
14	Glutathione		11907800	CTD
15	Piracetam			OFFSIDES
16	Thiamine			OFFSIDES
17	Ubiquinone			OFFSIDES
18	tegaserod			OFFSIDES
19	tegaserod			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Adrenoleukodystrophy	43.4%
2	Leigh Disease	42.9%
3	Galactosemias	40.3%
4	Urea Cycle Disorders, Inborn	40.3%
5	Tyrosinemias	40.3%
6	Hepatolenticular Degeneration	39.7%
7	Homocystinuria	36%
8	Carbamoyl-Phosphate Synthase I Deficiency Disease	35.1%
9	Fabry Disease	34.8%
10	Menkes Kinky Hair Syndrome	34.4%
11	Refsum Disease	34.3%
12	Zellweger Syndrome	32.7%
13	Glycogen storage disease type II	31.6%
14	Canavan Disease	28.5%
15	Alexander Disease	28.5%
16	Gaucher Disease	26.8%
17	Myelinolysis, Central Pontine	23.1%
18	Niemann-Pick Disease, Type C	22.5%
19	Dementia, Vascular	22.4%
20	Tay-Sachs Disease	22.2%
21	Pseudohypoparathyroidism	21.4%
22	Basal Ganglia Cerebrovascular Disease	20.9%
23	Smith-Lemli-Opitz Syndrome	20.7%
24	Leukomalacia, Periventricular	20.1%
25	Mitochondrial Encephalomyopathies	20%
26	Reye Syndrome	19.4%
27	Hepatic Encephalopathy	19.3%
28	Familial Periodic Paralysis	19%
29	Vascular Headaches	18.9%
30	Hyperphosphaturia	18.8%
31	Brain Infarction	18.2%
32	Vasculitis, Central Nervous System	18.1%
33	Carotid Artery Injuries	17.5%
34	Amyloid Neuropathies, Familial	17.4%
35	Wernicke Encephalopathy	17.3%
36	Wasting Syndrome	17.2%
37	Amino Acid Metabolism, Inborn Errors	17.2%
38	Carbohydrate Metabolism, Inborn Errors	17.2%
39	Metal Metabolism, Inborn Errors	17.2%
40	Progeria	17.2%
41	Lysosomal Storage Diseases	17.2%
42	Peroxisomal Disorders	17.2%
43	Basal Ganglia Hemorrhage	17%
44	Moyamoya Disease	16.9%
45	Meningoencephalitis	16.9%
46	Kearns-Sayre syndrome	16.8%
47	Hyperhomocysteinemia	16.6%
48	Cytochrome-c Oxidase Deficiency	16.6%
49	Familial Hypophosphatemic Rickets	16.6%
50	Intracranial Embolism and Thrombosis	16.5%
51	Friedreich Ataxia	16.4%
52	Kernicterus	16.3%
53	Carotid Artery Diseases	16.2%
54	Brain Ischemia	16.2%
55	Cerebrovascular accident	16.2%
56	Vasospasm, Intracranial	16.2%
57	Intracranial Arterial Diseases	16.2%
58	Hypoxia-Ischemia, Brain	15.9%
59	Lactose Intolerance	15.8%
60	Infarction, Middle Cerebral Artery	15.7%
61	Infarction, Anterior Cerebral Artery	15.7%
62	Infarction, Posterior Cerebral Artery	15.7%
63	Ataxia Telangiectasia	15.7%
64	Dandy-Walker Syndrome	15.3%
65	Multiple System Atrophy	15.2%
66	Lupus Vasculitis, Central Nervous System	15.1%
67	Hypercalcemia	15%
68	Hypocalcemia	15%
69	Milk-Alkali Syndrome	15%
70	Subarachnoid Hemorrhage, Traumatic	14.8%
71	Hypolipoproteinemias	14.7%
72	Pneumocephalus	14.6%
73	Encephalomyelitis	14.5%
74	Osteopenia	14.4%
75	Brain Diseases, Metabolic	14.3%
76	Hyperlipoproteinemia Type IV	14.3%
77	Hyperlipoproteinemia Type V	14.3%
78	Amyotrophic Lateral Sclerosis	14.2%
79	Lewy Body Disease	14.2%
80	Rickets	14.2%
81	Neuronal Ceroid-Lipofuscinoses	14.1%
82	Marchiafava-Bignami Disease	14.1%
83	Acid-Base Imbalance	14.1%
84	Calcium Metabolism Disorders	14.1%
85	Iron Metabolism Disorders	14.1%
86	Phosphorus Metabolism Disorders	14.1%
87	Water-Electrolyte Imbalance	14.1%
88	Lipid Metabolism Disorders	14.1%
89	Glucose Metabolism Disorders	14.1%
90	Chronic Fatigue Syndrome	14.1%
91	Subdural Effusion	14%
92	Huntington Disease	13.9%
93	Brain Abscess	13.8%
94	Lipodystrophy	13.7%
95	Carotid Artery Thrombosis	13.7%
96	Cerebral Infarction	13.6%
97	Brain Stem Infarctions	13.6%
98	Mucopolysaccharidosis II	13.5%
99	Hyperlipidemia, Familial Combined	13.5%
100	Stiff-Person Syndrome	13.5%
101	Carotid Artery, Internal, Dissection	13.2%
102	Putaminal Hemorrhage	13.2%
103	Mucopolysaccharidosis III	13%
104	Pituitary Apoplexy	12.9%
105	Hyperlipoproteinemia Type III	12.9%
106	Myotonic Dystrophy	12.7%
107	Renal tubular acidosis	12.6%
108	Hypokalemic periodic paralysis	12.6%
109	Ocular Motility Disorders	12.5%
110	Cyclophoria	12.5%
111	Carotid Stenosis	12.3%
112	Intracranial Aneurysm	12.3%
113	Dystonia Musculorum Deformans	12.3%
114	Epilepsy, Post-Traumatic	12.2%
115	Brain Injuries	12.1%
116	Cockayne Syndrome	12.1%
117	Brain Neoplasms	12.1%
118	Akinetic Mutism	12.1%
119	Anoxic Encephalopathy	12.1%
120	Basal Ganglia Diseases	12.1%
121	Brain Damage, Chronic	12.1%
122	Cerebellar Diseases	12.1%
123	Encephalitis	12.1%
124	Encephalomalacia	12.1%
125	Epilepsy	12.1%
126	Hydrocephalus	12.1%
127	Congenital Hydrocephalus	12.1%
128	Hypothalamic Diseases	12.1%
129	Thalamic Diseases	12.1%
130	Intracranial Hypertension	12.1%
131	Aura	12.1%
132	Leukoencephalopathy	12.1%
133	Neuroaxonal Dystrophies	12.1%
134	Headache Disorders	12.1%
135	Intracranial Hypotension	12.1%
136	Brain Edema	12.1%
137	Brain Hypoxia	12.1%
138	Aqueductal Stenosis	12.1%
139	Werner Syndrome	11.9%
140	Brain Hemorrhage, Traumatic	11.9%
141	Cerebral Amyloid Angiopathy	11.8%
142	Parkinsonian Disorders	11.7%
143	Vertebral Artery Dissection	11.6%
144	Fibromyalgia	11.6%
145	Gout	11.5%
146	Albinism	11.5%
147	Intracranial Arteriosclerosis	11.5%
148	Cerebral Atherosclerosis	11.5%
149	Cerebral Arteriosclerosis	11.5%
150	Progressive supranuclear palsy	11.4%
151	Giant Cell Arteritis	11.4%
152	Temporal Arteritis	11.4%
153	Lateral Medullary Syndrome	11.3%
154	Epidural Abscess	11.3%
155	Alkaptonuria	11.2%
156	Glycogen Storage Disease	11.2%
157	Hypophosphatasia	11.2%
158	Propionic acidemia	11.2%
159	Dihydropyrimidine Dehydrogenase Deficiency	11.2%
160	Cystinosis	11.2%
161	Brain Diseases, Metabolic, Inborn	11.2%
162	Leukoencephalopathy, Progressive Multifocal	11.1%
163	Optic Atrophy, Hereditary, Leber	11.1%
164	Cerebral Thrombosis	11.1%
165	Intracranial Embolism	11.1%
166	Intracranial Thrombosis	11.1%
167	Myositis	11.1%
168	Dementia	11.1%
169	Myotonic Disorders	11.1%
170	Ichthyosis, X-Linked	11.1%
171	Subacute Combined Degeneration	11%
172	Glycosuria, Renal	11%
173	Posterior Leukoencephalopathy Syndrome	10.9%
174	Posterior reversible encephalopathy syndrome	10.9%
175	Poliomyelitis	10.8%
176	Hypoalphalipoproteinemias	10.8%
177	Cerebral Arterial Diseases	10.8%
178	Vertebrobasilar Insufficiency	10.8%
179	Basilar Artery Stenosis	10.8%
180	Vertebral Artery Stenosis	10.8%
181	Intracranial Hemorrhage, Hypertensive	10.8%
182	Transient Cerebral Ischemia	10.8%
183	Shy-Drager Syndrome	10.7%
184	Motor Neuron Disease	10.7%
185	Brain Death	10.7%
186	Sjogren-Larsson Syndrome	10.6%
187	Parkinson Disease	10.5%
188	Amblyopia	10.5%
189	Antley-Bixler Syndrome Phenotype	10.3%
190	Myelitis	10.3%
191	Medial Tibial Stress Syndrome	10.2%
192	Meningitis	10.2%
193	Movement Disorders	10.2%
194	Pachymeningitis	10.2%
195	Spinal Cord Diseases	10.2%
196	Muscular Dystrophy	10.1%
197	Eosinophilia-Myalgia Syndrome	10.1%
198	Spinal Muscular Atrophy	10.1%
199	Progressive Muscular Atrophy	10.1%
200	Cerebellar Neoplasms	10%
201	Subarachnoid Hemorrhage	9.9%
202	Cerebral Hemorrhage	9.9%
203	Neuroleptic Malignant Syndrome	9.7%
204	Mitochondrial Diseases	9.7%
205	Myotonia Congenita	9.7%
206	Meige Syndrome	9.6%
207	Cerebral Ventriculitis	9.6%
208	Ophthalmoplegic Migraine	9.6%
209	Spinal Cord Vascular Diseases	9.6%
210	Miller Fisher Syndrome	9.5%
211	Congenital Hyperinsulinism	9.5%
212	Leukoencephalitis, Acute Hemorrhagic	9.5%
213	Renal Aminoacidurias	9.5%
214	Fanconi Syndrome	9.5%
215	Pseudohypoaldosteronism	9.5%
216	Liddle Syndrome	9.5%
217	Central Nervous System Infection	9.5%
218	Limbic Encephalitis	9.3%
219	Osteomalacia	9.3%
220	Amnesia, Transient Global	9.3%
221	Striatonigral Degeneration	9.3%
222	Prion Diseases	9.1%
223	Compartment syndromes	8.9%
224	Creutzfeldt-Jakob disease	8.8%
225	Restless Legs Syndrome	8.8%
226	Myoclonic Epilepsy	8.7%
227	Epilepsy, Temporal Lobe	8.7%
228	Epilepsy, Rolandic	8.7%
229	Benign Rolandic Epilepsy	8.7%
230	Lafora Disease	8.7%
231	Unverricht-Lundborg Syndrome	8.7%
232	Nutrition Disorders	8.7%
233	Myalgia	8.7%
234	Polyradiculoneuropathy	8.7%
235	Polyradiculoneuritis	8.7%
236	Porphyrias, Hepatic	8.6%
237	MELAS Syndrome	8.5%
238	Spinal Cord Injuries	8.5%
239	Fanconi Anemia	8.5%
240	Asterixis	8.4%
241	Ballismus	8.4%
242	Sinus Thrombosis, Intracranial	8.4%
243	Cranial nerve diseases	8.4%
244	Demyelinating Diseases	8.4%
245	Demyelination	8.4%
246	Chronobiology Disorders	8.4%
247	Bloom Syndrome	8.4%
248	Osteoporosis	8.4%
249	Bone Demineralization, Pathologic	8.4%
250	Post-Traumatic Osteoporosis	8.4%
251	Myelitis, Transverse	8.3%
252	Glycogen Storage Disease Type I	8.3%
253	Glycogen Storage Disease Type V	8.3%
254	Pituitary Adenoma	8.3%
255	Pituitary Neoplasms	8.3%
256	Tuberous Sclerosis	8.2%
257	Acidosis	8.2%
258	Alkalosis	8.2%
259	Amyloidosis	8.2%
260	Calcinosis	8.2%
261	Hyperglycemia	8.2%
262	Hyperinsulinism	8.2%
263	Hyperkalemia	8.2%
264	Hypernatremia	8.2%
265	Hypoglycemia	8.2%
266	Hypokalemia	8.2%
267	Hyponatremia	8.2%
268	Xanthomatosis	8.2%
269	Hypophosphatemia	8.2%
270	Metabolic acidosis	8.2%
271	Dyslipidemias	8.2%
272	Iron Overload	8.2%
273	Xanthoma	8.2%
274	Muscular Dystrophy, Duchenne	8.2%
275	Arthritis, Gouty	8.1%
276	Isaacs syndrome	8.1%
277	Myasthenic Syndromes, Congenital	8.1%
278	Presenile dementia	8.1%
279	Senile dementia	8.1%
280	Subclavian Steal Syndrome	8.1%
281	Toxoplasmosis, Cerebral	8%
282	MPTP Poisoning	7.9%
283	HIV Wasting Syndrome	7.8%
284	Frontotemporal dementia	7.8%
285	Trauma, Nervous System	7.8%
286	Complex Regional Pain Syndromes	7.7%
287	Nervous System Neoplasms	7.7%
288	Neurologic Manifestations	7.7%
289	Neurotoxicity Syndromes	7.7%
290	Diabetic Ketoacidosis	7.6%
291	Diabetes Mellitus	7.6%
292	Renal Osteodystrophy	7.6%
293	Renal rickets	7.6%
294	Hand-Arm Vibration Syndrome	7.6%
295	Opsoclonus-Myoclonus Syndrome	7.5%
296	Alstrom Syndrome	7.5%
297	Meningitis, Bacterial	7.5%
298	Meningitis, Fungal	7.5%
299	Dehydration	7.5%
300	Lipomatosis	7.5%
301	Water Intoxication	7.5%
302	Guillain-Barre Syndrome	7.5%
303	Ischemic contracture	7.5%
304	Achlorhydria	7.5%
305	Celiac Disease	7.5%
306	Sprue, Tropical	7.5%
307	Steatorrhea	7.5%
308	Sprue	7.5%
309	Paraneoplastic Cerebellar Degeneration	7.4%
310	Encephalomyelitis, Acute Disseminated	7.4%
311	Lambert-Eaton Myasthenic Syndrome	7.3%
312	Neuromuscular Junction Diseases	7.3%
313	Peripheral Nervous System Diseases	7.3%
314	Akathisia, Drug-Induced	7.2%
315	Xeroderma Pigmentosum	7.2%
316	Brain Injuries, Diffuse	7.2%
317	Traumatic Brain Injury	7.2%
318	Cerebral Palsy	7.2%
319	Epilepsies, Partial	7.2%
320	Epilepsy, Generalized	7.2%
321	Pseudotumor Cerebri	7.2%
322	Hypertensive Encephalopathy	7.2%
323	Simple Partial Seizures	7.2%
324	Epilepsy, Reflex	7.2%
325	Headache Disorders, Primary	7.2%
326	Headache Disorders, Secondary	7.2%
327	Medication overuse headache	7.2%
328	Cerebellar Ataxia	7.2%
329	Supratentorial Neoplasms	7.2%
330	Smith-Magenis syndrome	7.1%
331	Sleep Wake Disorders	7.1%
332	Aicardi's syndrome	7.1%
333	Arthrogryposis	7.1%
334	Peripheral Nerve Injuries	7.1%
335	HIV-Associated Lipodystrophy Syndrome	7.1%
336	Myasthenia Gravis	7%
337	Cavernous Sinus Thrombosis	7%
338	Sagittal Sinus Thrombosis	7%
339	Cystinuria	7%
340	Hematoma, Subdural	6.9%
341	Hematoma, Epidural, Cranial	6.9%
342	Dyskinesia, Drug-Induced	6.9%
343	Glycosuria	6.9%
344	Persistent Vegetative State	6.8%
345	CREST Syndrome	6.8%
346	Spinal Cord Neoplasms	6.7%
347	Pituitary Diseases	6.7%
348	Nesidioblastosis	6.7%
349	Thoracic Outlet Syndrome	6.6%
350	Polymyositis	6.6%
351	Kluver-Bucy Syndrome	6.6%
352	Juvenile Myoclonic Epilepsy	6.5%
353	Myoclonic Epilepsies, Progressive	6.5%
354	Botulism	6.5%
355	Tetany	6.4%
356	Welander Distal Myopathy	6.4%
357	Necrobiosis Lipoidica Diabeticorum	6.3%
358	Mitochondrial Myopathies	6.2%
359	Autonomic Dysreflexia	6.2%
360	Optic Neuropathy, Ischemic	6.1%
361	Anterior Ischemic Optic Neuropathy	6.1%
362	Muscle Cramp	6.1%
363	Sturge-Weber Syndrome	6.1%
364	Orbital Myositis	6.1%
365	Pyomyositis	6%
366	Causalgia	6%
367	Central Nervous System Cysts	6%
368	Holoprosencephaly	6%
369	Angioedemas, Hereditary	6%
370	Marfan Syndrome	5.9%
371	Contracture	5.9%
372	Myocardial Ischemia	5.9%
373	Cerebrovascular Disorders	5.9%
374	Cerebrovascular Insufficiency	5.9%
375	Progressive bulbar palsy	5.9%
376	Bulbar palsy	5.9%
377	Auditory Perceptual Disorders	5.8%
378	Nail-Patella Syndrome	5.8%
379	Prader-Willi Syndrome	5.8%
380	Charcot-Marie-Tooth Disease	5.7%
381	Spinal Cord Ischemia	5.7%
382	Muscle Weakness	5.7%
383	Arachnoiditis	5.6%
384	Aseptic Meningitis	5.6%
385	Syringomyelia	5.6%
386	Essential Tremor	5.6%
387	Familial Tremor	5.6%
388	Pneumorrhachis	5.6%
389	Writer's Cramp	5.6%
390	Tuberculosis, Meningeal	5.6%
391	Neuromuscular Diseases	5.6%
392	Variegate Porphyria	5.6%
393	Acute intermittent porphyria	5.6%
394	Porphyria Cutanea Tarda	5.6%
395	Myocardial Reperfusion Injury	5.6%
396	Hematoma, Subdural, Intracranial	5.6%
397	Hematoma, Subdural, Chronic	5.6%
398	Hematoma, Subdural, Acute	5.6%
399	Polymyalgia Rheumatica	5.4%
400	Neuromyelitis Optica	5.4%
401	Osteoporosis, Postmenopausal	5.4%
402	Dural Arteriovenous Fistula	5.4%
403	Rubinstein-Taybi Syndrome	5.4%
404	Sleep Disorders, Circadian Rhythm	5.3%
405	Multiple Epiphyseal Dysplasia	5.3%
406	Osteochondrodysplasias	5.3%
407	Retinal Vein Occlusion	5.3%
408	Acidosis, Lactic	5.3%
409	Calciphylaxis	5.3%
410	Hemosiderosis	5.3%
411	Ketosis	5.3%
412	Ketonuria	5.3%
413	Ketoacidosis	5.3%
414	Ketonemia	5.3%
415	Vascular calcification	5.3%
416	Anterior Compartment Syndrome	5.3%
417	Aortic Aneurysm	5.3%
418	Aortitis	5.3%
419	Leriche Syndrome	5.3%
420	Periphlebitis	5.3%
421	Phlebitis	5.3%
422	Thromboangiitis Obliterans	5.3%
423	Abdominal Compartment Syndrome	5.3%
424	Fragile X Syndrome	5.3%
425	Muscle Rigidity	5.2%
426	Muscle Spasticity	5.2%
427	Cogwheel Rigidity	5.2%
428	Nuchal Rigidity	5.2%
429	AIDS Dementia Complex	5.2%
430	Central Nervous System Fungal Infections	5.2%
431	Conus Medullaris Syndrome	5.2%
432	Kartagener Syndrome	5.2%
433	Subacute Sclerosing Panencephalitis	5.1%
434	Cystic Fibrosis	5.1%
435	Arteriovenous fistula	5%
436	Scimitar Syndrome	5%
437	Dwarfism	5%
438	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	5%
439	CHARGE Syndrome	4.9%
440	Hydranencephaly	4.9%
441	Neural Tube Defects	4.9%
442	Tethered Cord Syndrome	4.9%
443	Iniencephaly	4.9%
444	Craniorachischisis	4.9%
445	Exencephaly	4.9%
446	Septo-Optic Dysplasia	4.9%
447	Cortical Dysplasia	4.9%
448	Malformations of Cortical Development	4.9%
449	Scrapie	4.9%
450	Central Cord Syndrome	4.9%
451	Aneurysm	4.9%
452	Angiomatosis	4.9%
453	Aortic Diseases	4.9%
454	Arterial Occlusive Diseases	4.9%
455	Hyperemia	4.9%
456	Hypotension	4.9%
457	Myofascial Pain Syndromes	4.9%
458	Rhabdomyolysis	4.9%
459	Superior Vena Cava Syndrome	4.9%
460	Telangiectasis	4.9%
461	Vasculitis	4.9%
462	Venous Insufficiency	4.9%
463	Peripheral Vascular Diseases	4.9%
464	Embolism and Thrombosis	4.9%
465	Angiodysplasia	4.9%
466	Capillary Leak Syndrome	4.9%
467	Prehypertension	4.9%
468	Malignant Atrophic Papulosis	4.9%
469	Cri-du-Chat Syndrome	4.9%
470	Down Syndrome	4.9%
471	Trisomy 21	4.9%
472	Shwartzman Phenomenon	4.8%
473	Olfactory Nerve Injuries	4.8%
474	Myasthenia Gravis, Autoimmune, Experimental	4.8%
475	Chorea	4.8%
476	Acidosis, Respiratory	4.8%
477	Adiposis Dolorosa	4.8%
478	Alkalosis, Respiratory	4.8%
479	Brain Concussion	4.8%
480	Insulin Resistance	4.8%
481	Post-Traumatic Headache	4.8%
482	Tension Headache	4.8%
483	Epilepsy, Complex Partial	4.8%
484	Migraine Disorders	4.8%
485	Abdominal Migraine	4.8%
486	Status Migrainosus	4.8%
487	Cervicogenic Headache	4.8%
488	Diffuse Axonal Injury	4.8%
489	Brain Stem Neoplasms	4.8%
490	Central Nervous System Bacterial Infections	4.8%
491	Child Nutrition Disorders	4.7%
492	Hypervitaminosis A	4.7%
493	Infant Nutrition Disorders	4.7%
494	Malnutrition	4.7%
495	Osteogenesis Imperfecta	4.6%
496	Coronary Aneurysm	4.6%
497	Acrodynia	4.6%
498	Neoplastic Syndromes, Hereditary	4.5%
499	Vascular System Injuries	4.5%
500	Facial Nerve Injuries	4.5%
501	Gestational Diabetes	4.5%
502	Latent Autoimmune Diabetes in Adults	4.5%
503	Horner Syndrome	4.5%
504	Aortic Rupture	4.5%
505	Anemia, Sickle Cell	4.5%
506	Thalassemia	4.5%
507	Williams Syndrome	4.5%
508	Diabetes Mellitus, Experimental	4.5%
509	Hepatic Veno-Occlusive Disease	4.5%
510	Peliosis Hepatis	4.5%
511	Tendinitis	4.5%
512	Varicocele	4.5%
513	Tendinopathy	4.5%
514	Brain Contusion	4.4%
515	Diabetic Angiopathies	4.4%
516	Pelger-Huet Anomaly	4.4%
517	Reperfusion Injury	4.4%
518	Splenic Infarction	4.4%
519	Vascular Neoplasms	4.4%
520	Vasoplegia	4.4%
521	Nephrocalcinosis	4.4%
522	Hemorrhoids	4.4%
523	Thrombophlebitis	4.4%
524	Empty Sella Syndrome	4.4%
525	Hyperpituitarism	4.4%
526	Hypopituitarism	4.4%
527	Hypophysitis	4.4%
528	Postphlebitic Syndrome	4.4%
529	Reflex Sympathetic Dystrophy	4.4%
530	Brachial Plexus Neuritis	4.4%
531	Neuralgic Amyotrophy	4.4%
532	Dysautonomia	4.4%
533	Vagus Nerve Disorder	4.4%
534	Glossopharyngeal Neuralgia	4.4%
535	Abducens Nerve Diseases	4.4%
536	Heavy Metal Poisoning, Nervous System	4.4%
537	Tauopathies	4.4%
538	Trochlear Nerve Diseases	4.4%
539	Alice in Wonderland Syndrome	4.3%
540	Meningitis, Cryptococcal	4.3%
541	Meningitis, Listeria	4.3%
542	Meningitis, Haemophilus	4.3%
543	Meningitis, Pneumococcal	4.3%
544	Pseudoxanthoma Elasticum	4.3%
545	Temporomandibular Joint Dysfunction Syndrome	4.2%
546	Cardiovascular Abnormalities	4.2%
547	Jet Lag Syndrome	4.2%
548	Duane Retraction Syndrome	4.2%
549	Primary amyloidosis	4.1%
550	Mesenteric vascular insufficiency	4.1%
551	Optic Neuropathy	4.1%
552	Angioedema	4%
553	Beckwith-Wiedemann Syndrome	4%
554	Wolf-Hirschhorn Syndrome	4%
555	Colitis, Ischemic	4%
556	Multiple Sclerosis	4%
557	Neuritis	4%
558	Polyneuritis	4%
559	Radiculitis	4%
560	Polyneuropathy	4%
561	Mononeuritis	4%
562	Mononeuropathies	4%
563	Brachial Plexus Neuropathies	4%
564	Radiculopathy	4%
565	Mononeuropathy Multiplex	4%
566	Nerve Root Compression	4%
567	Facial Nerve Diseases	4%
568	Craniocerebral Trauma	4%
569	Parasomnia	4%
570	Dyssomnias	4%
571	Rett Syndrome	4%
572	Torticollis	4%
573	Vestibulocochlear Nerve Diseases	4%
574	Decerebrate State	4%
575	Hemiparesis	4%
576	Meningism	4%
577	Paresis	4%
578	Seizures	4%
579	Sensation Disorders	4%
580	Central Nervous System Neoplasms	4%
581	Complex partial seizures	4%
582	Monoparesis	4%
583	Neurogenic Inflammation	4%
584	Gait Disorders, Neurologic	4%
585	Neuromuscular Manifestations	4%
586	Sweating, Gustatory	4%
587	Auriculotemporal Syndrome	4%
588	Hypotension, Orthostatic	3.9%
589	Post-Exercise Hypotension	3.9%
590	Behcet Syndrome	3.9%
591	Mobius Syndrome	3.9%
592	Wiskott-Aldrich Syndrome	3.9%
593	Hypercholesterolemia	3.8%
594	Hyperlipoproteinemias	3.8%
595	Hypertriglyceridemia	3.8%
596	Acromegaly	3.8%
597	Anterior Spinal Artery Syndrome	3.8%
598	Autoimmune Lymphoproliferative Syndrome	3.8%
599	Temporomandibular Joint Disorders	3.8%
600	May-Thurner Syndrome	3.8%
601	West Nile Fever	3.8%
602	Dermatomyositis	3.8%
603	Musculoskeletal Pain	3.7%
604	Ophthalmoplegia	3.7%
605	External Ophthalmoplegia	3.7%
606	Pectus carinatum	3.7%
607	Coronary Thrombosis	3.7%
608	Coronary Artery Disease	3.7%
609	Blue Toe Syndrome	3.7%
610	Pupil Disorders	3.7%
611	Neurobehavioral Manifestations	3.7%
612	Neuritis, Autoimmune, Experimental	3.7%
613	Classical Lissencephalies and Subcortical Band Heterotopias	3.7%
614	Paraneoplastic Encephalomyelitis	3.7%
615	Diabetic Neuropathies	3.7%
616	Diabetic Amyotrophy	3.7%
617	Diabetic Autonomic Neuropathy	3.7%
618	Uveomeningoencephalitic Syndrome	3.7%
619	Neuralgia	3.7%
620	Neuropathic pain	3.7%
621	Vertigo	3.6%
622	Alcohol-Induced Disorders, Nervous System	3.6%
623	Tarsal Tunnel Syndrome	3.6%
624	Cauda Equina Syndrome	3.6%
625	Cluster Headache	3.6%
626	Migraine with Aura	3.6%
627	Familial Hemiplegic Migraine	3.6%
628	Chronic Paroxysmal Hemicrania	3.6%
629	SUNCT Syndrome	3.6%
630	Paroxysmal Hemicrania	3.6%
631	Choroid Plexus Papilloma	3.6%
632	Kallmann Syndrome	3.6%
633	Coronary heart disease	3.5%
634	Hip Contracture	3.5%
635	Myocardial Infarction	3.5%
636	Acute Coronary Syndrome	3.5%
637	Nocturnal Myoclonus Syndrome	3.5%
638	Vocal Cord Paralysis	3.5%
639	Aortic Aneurysm, Abdominal	3.5%
640	Aortic Aneurysm, Thoracic	3.5%
641	Ectodermal Dysplasia	3.5%
642	Aplasia Cutis Congenita	3.5%
643	Voice Disorders	3.4%
644	Voice Disturbance	3.4%
645	Anencephaly	3.4%
646	Carpal Tunnel Syndrome	3.3%
647	Sciatica	3.3%
648	Hyperprolactinemia	3.3%
649	Scurvy	3.3%
650	Pick Disease of the Brain	3.3%
651	Congenital Hypothyroidism	3.3%
652	Kounis Syndrome	3.3%
653	Toxoplasmosis, Congenital	3.2%
654	Alcohol Withdrawal Seizures	3.2%
655	Angina Pectoris	3.2%
656	Polyarteritis Nodosa	3.2%
657	Takayasu Arteritis	3.2%
658	Reflex, Abnormal	3.1%
659	Hyporeflexia	3.1%
660	Hyperreflexia	3.1%
661	Tardive Dyskinesia	3.1%
662	Basal Cell Nevus Syndrome	3.1%
663	Tuberculosis, Central Nervous System	3.1%
664	Pectus excavatum	3%
665	Polycystic Kidney Diseases	3%
666	Embolism, Amniotic Fluid	3%
667	Cerebrospinal Fluid Otorrhea	3%
668	Cerebrospinal Fluid Rhinorrhea	3%
669	Osteoarthropathy, Secondary Hypertrophic	3%
670	Fasciitis, Plantar	3%
671	Gait Ataxia	3%
672	Sickle Cell Trait	3%
673	Bone Diseases	3%
674	Fasciitis	3%
675	Foot Deformities	3%
676	Heart Diseases	3%
677	Arthropathy	3%
678	Deformity	3%
679	Aneurysm, Dissecting	2.9%
680	Arteriosclerosis	2.9%
681	Arteritis	2.9%
682	Embolism	2.9%
683	Erythromelalgia	2.9%
684	Fibrodysplasia Ossificans Progressiva	2.9%
685	Fibromuscular Dysplasia	2.9%
686	Malignant Hypertension	2.9%
687	Myoglobinuria	2.9%
688	Myositis Ossificans	2.9%
689	Familial Mediterranean Fever	2.9%
690	Raynaud Disease	2.9%
691	Tenosynovitis	2.9%
692	Thromboembolism	2.9%
693	Thrombosis	2.9%
694	Essential Hypertension	2.9%
695	Aneurysm, Ruptured	2.9%
696	Iliac Aneurysm	2.9%
697	Pulmonary artery stenosis	2.9%
698	White Coat Hypertension	2.9%
699	Systemic Vasculitis	2.9%
700	Embolus	2.9%
701	Retinal Dysplasia	2.8%
702	Neuroaspergillosis	2.8%
703	Primary Ciliary Dyskinesia	2.8%
704	Noonan Syndrome	2.8%
705	Aniridia	2.8%
706	Epidermolysis Bullosa	2.8%
707	Optic Nerve Glioma	2.8%
708	Meningomyelocele	2.8%
709	Spina Bifida	2.8%
710	Acrocephalosyndactylia	2.8%
711	Akathisia	2.8%
712	Restlessness	2.8%
713	Psychomotor Agitation	2.8%
714	Lemierre Syndrome	2.8%
715	Dextrocardia	2.7%
716	Platybasia	2.7%
717	Tricuspid Atresia	2.7%
718	Arrhythmogenic Right Ventricular Dysplasia	2.7%
719	Jaw Diseases	2.7%
720	Deficiency Diseases	2.7%
721	Starvation	2.7%
722	Refeeding Syndrome	2.7%
723	Osteochondritis	2.7%
724	Microcephaly	2.7%
725	Macrocephaly	2.7%
726	Metatarsalgia	2.7%
727	Cartilage Diseases	2.7%
728	Fetal Diseases	2.7%
729	Foot Diseases	2.7%
730	Klippel-Feil Syndrome	2.7%
731	Myopathy	2.7%
732	Pregnancy Complications, Cardiovascular	2.7%
733	Rheumatism	2.7%
734	Chondromalacia	2.7%
735	Synostosis	2.7%
736	Acoustic Neuroma	2.7%
737	Cubital Tunnel Syndrome	2.7%
738	Pseudorabies	2.7%
739	Retinal Artery Occlusion	2.7%
740	Retinal Vasculitis	2.7%
741	Hypertensive Retinopathy	2.7%
742	Craniosynostosis	2.6%
743	Syndactyly	2.6%
744	Brachycephaly	2.6%
745	Vasculitis, Leukocytoclastic, Cutaneous	2.6%
746	Enthesopathy	2.6%
747	Gastric Antral Vascular Ectasia	2.6%
748	Varicose Ulcer	2.6%
749	Primary Graft Dysfunction	2.6%
750	Coma, Post-Head Injury	2.6%
751	POEMS Syndrome	2.6%
752	Acute Chest Syndrome	2.6%
753	Neurosyphilis	2.6%
754	Prolactinoma	2.6%
755	Growth Hormone-Secreting Pituitary Adenoma	2.6%
756	Congenital nystagmus	2.6%
757	Meningocele	2.6%
758	Encephalocele	2.6%
759	neurofibroma	2.5%
760	Rheumatoid Vasculitis	2.5%
761	Turner Syndrome	2.5%
762	Cutis Laxa	2.4%
763	Mesenteric Vascular Occlusion	2.4%
764	Mucocutaneous Lymph Node Syndrome	2.4%
765	Diabetic Retinopathy	2.4%
766	Retinitis Pigmentosa	2.4%
767	Pigmentary retinopathy	2.4%
768	Dupuytren Contracture	2.4%
769	Livedo Reticularis	2.4%
770	Porokeratosis	2.4%
771	Keratoderma, Palmoplantar	2.4%
772	Chronic granulomatous disease	2.4%
773	Renal hypertension	2.4%
774	Renal Artery Obstruction	2.4%
775	Renal Artery Stenosis	2.4%
776	Hemangioma, Cavernous	2.4%
777	Gait Apraxia	2.4%
778	Lyme Neuroborreliosis	2.4%
779	Sciatic Neuropathy	2.4%
780	Ulnar Neuropathies	2.4%
781	Lesion of Sciatic Nerve	2.4%
782	Ulnar Neuritis	2.4%
783	Radial nerve compression	2.4%
784	Radial Tunnel Syndrome	2.4%
785	Peroneal Neuropathies	2.4%
786	Radial Neuropathy	2.4%
787	Median Neuropathy	2.4%
788	Sciatic Nerve Palsy	2.4%
789	Femoral Neuropathy	2.4%
790	Tibial Neuropathy	2.4%
791	Ulnar Nerve Palsy	2.4%
792	Radial nerve palsy	2.4%
793	Multiple Sclerosis, Chronic Progressive	2.4%
794	Multiple Sclerosis, Relapsing-Remitting	2.4%
795	Limb Deformities, Congenital	2.4%
796	Craniofacial Abnormalities	2.4%
797	Meconium Aspiration Syndrome	2.4%
798	Porencephaly	2.3%
799	Coronary Occlusion	2.3%
800	Microvascular Angina	2.3%
801	Coronary Stenosis	2.3%
802	ST segment elevation myocardial infarction	2.3%
803	Nelson Syndrome	2.3%
804	Jaw Abnormalities	2.3%
805	Peutz-Jeghers Syndrome	2.2%
806	Thrombasthenia	2.2%
807	Antithrombin III Deficiency	2.2%
808	Protein C Deficiency	2.2%
809	Afibrinogenemia	2.2%
810	Cryoglobulinemia	2.2%
811	Factor VII Deficiency	2.2%
812	Factor X Deficiency	2.2%
813	Factor XII Deficiency	2.2%
814	Hemophilia A	2.2%
815	Activated Protein C Resistance	2.2%
816	Factor II deficiency	2.2%
817	Factor VIII Deficiency	2.2%
818	Factor V deficiency	2.2%
819	Factor XI Deficiency	2.2%
820	Hypoprothrombinemias	2.2%
821	Diabetic Foot	2.2%
822	Anemia, Diamond-Blackfan	2.2%
823	Optic Atrophy	2.2%
824	Optic Neuritis	2.2%
825	Papilledema	2.2%
826	Strabismus	2.2%
827	Tolosa-Hunt Syndrome	2.2%
828	Arsenic Poisoning	2.2%
829	Facial Injuries	2.2%
830	Facial Neuralgia	2.2%
831	Sleep Talking	2.2%
832	Manganese Poisoning	2.2%
833	Sleep Disorders, Intrinsic	2.2%
834	Orthostatic intolerance	2.2%
835	Anosmia	2.2%
836	Ataxia	2.2%
837	Athetosis	2.2%
838	Catalepsy	2.2%
839	Dystonia	2.2%
840	Hemiplegia	2.2%
841	Locked-In Syndrome	2.2%
842	Meningeal Neoplasms	2.2%
843	Muscle Hypertonia	2.2%
844	Muscle hypotonia	2.2%
845	Myoclonus	2.2%
846	Myotonia	2.2%
847	Paraplegia	2.2%
848	Pseudobulbar Palsy	2.2%
849	Quadriplegia	2.2%
850	Spasm	2.2%
851	Spastic Paraplegia	2.2%
852	Status Epilepticus	2.2%
853	Taste Disorders	2.2%
854	Tremor	2.2%
855	Monoplegia	2.2%
856	Hypokinesia	2.2%
857	Paraparesis	2.2%
858	Bradykinesia	2.2%
859	Waxy flexibility	2.2%
860	Action Tremor	2.2%
861	Resting Tremor	2.2%
862	Dysosmia	2.2%
863	Quadriparesis	2.2%
864	Mercury Poisoning, Nervous System	2.2%
865	Olfaction Disorders	2.2%
866	Myokymia	2.2%
867	Lead Poisoning, Nervous System	2.2%
868	Vestibular Neuronitis	2.2%
869	Somatosensory Disorders	2.2%
870	Hyperkinesia	2.2%
871	Intention tremor	2.2%
872	Waterhouse-Friderichsen Syndrome	2.2%
873	Talipes	2.2%
874	Rheumatic Fever	2.2%
875	Gastroschisis	2.2%
876	Aortic coarctation	2.2%
877	Cor Triatriatum	2.2%
878	Coronary Vessel Anomalies	2.2%
879	Patent ductus arteriosus	2.2%
880	Ebstein Anomaly	2.2%
881	Heart Septal Defects	2.2%
882	Tetralogy of Fallot	2.2%
883	Transposition of Great Vessels	2.2%
884	Hypoplastic Left Heart Syndrome	2.2%
885	Shock, Cardiogenic	2.1%
886	Angina, Unstable	2.1%
887	Multiple Endocrine Neoplasia	2.1%
888	Osteoarthritis, Spine	2.1%
889	Obesity	2.1%
890	Dermatitis, Atopic	2.1%
891	Purpura, Hyperglobulinemic	2.1%
892	Vision Disorders	2%
893	Metamorphopsia	2%
894	Visual Impairment	2%
895	Facial Hemiatrophy	2%
896	Melkersson-Rosenthal Syndrome	2%
897	Hyperkeratosis, Epidermolytic	2%
898	Anisocoria	2%
899	Confusion	2%
900	Facial paralysis	2%
901	Lethargy	2%
902	Memory Disorders	2%
903	Perceptual Disorders	2%
904	Psychomotor Disorders	2%
905	Tonic Pupil	2%
906	Anhedonia	2%
907	Disorientation	2%
908	Facial Paresis	2%
909	Memory Loss	2%
910	Hemisensory Neglect	2%
911	Dysacusis	2%
912	Sleep Bruxism	2%
913	Muscular Atrophy	2%
914	Respiratory Paralysis	2%
915	Rheumatoid Arthritis	2%
916	Bacterial Endocarditis	2%
917	Juvenile arthritis	2%
918	Xeroderma	2%
919	Maxillofacial Abnormalities	2%
920	Long QT Syndrome	2%
921	Polycystic Kidney, Autosomal Dominant	2%
922	Prognathism	1.9%
923	Waldenstrom Macroglobulinemia	1.9%
924	Multiple Myeloma	1.9%
925	Arteriosclerosis Obliterans	1.9%
926	Atherosclerosis	1.9%
927	Air Embolism	1.9%
928	Endarteritis	1.9%
929	Venous Thrombosis	1.9%
930	Deep Vein Thrombosis	1.9%
931	Venous Thromboembolism	1.9%
932	Poland Syndrome	1.9%
933	Consciousness Disorders	1.9%
934	Mental Retardation	1.9%
935	Depressed Level of Consciousness	1.9%
936	Mental deficiency	1.9%
937	Intellectual Disability	1.9%
938	Laryngomalacia	1.9%
939	Bell Palsy	1.9%
940	Malaria, Cerebral	1.9%
941	Craniofacial Dysostosis	1.9%
942	Catatonia	1.9%
943	Herpes Zoster Oticus	1.9%
944	Neurocysticercosis	1.9%
945	Aphonia	1.9%
946	Sleep Deprivation	1.9%
947	Dysphonia	1.9%
948	Intermittent Claudication	1.8%
949	Pulmonary Embolism	1.8%
950	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	1.8%
951	Kwashiorkor	1.8%
952	Magnesium Deficiency	1.8%
953	Potassium Deficiency	1.8%
954	Protein Deficiency	1.8%
955	Avitaminosis	1.8%
956	Aortic Valve Stenosis	1.8%
957	Cardiomyopathy, Dilated	1.8%
958	Periarthritis	1.8%
959	Pulmonary Valve Stenosis	1.8%
960	No-Reflow Phenomenon	1.8%
961	Dermal Sinus	1.7%
962	Spina Bifida Cystica	1.7%
963	Spina Bifida Occulta	1.7%
964	Lissencephaly	1.7%
965	Polymicrogyria	1.7%
966	Pachygyria	1.7%
967	Schizencephaly	1.7%
968	Periventricular Nodular Heterotopia	1.7%
969	Coronary Restenosis	1.7%
970	Nephroblastoma	1.7%
971	Cleft Palate	1.7%
972	Hoarseness	1.6%
973	Abdominal Cramps	1.6%
974	Abnormalities, Drug-Induced	1.6%
975	Alcohol Withdrawal Delirium	1.6%
976	Amniotic Band Syndrome	1.6%
977	Arthritis	1.6%
978	Asphyxia Neonatorum	1.6%
979	Bone Diseases, Developmental	1.6%
980	Bursitis	1.6%
981	Cardiac Tamponade	1.6%
982	Endocarditis	1.6%
983	Cardiac Arrest	1.6%
984	Heart failure	1.6%
985	Hyperostosis	1.6%
986	Infant, Premature, Diseases	1.6%
987	Joint Instability	1.6%
988	Osteitis	1.6%
989	Osteitis Deformans	1.6%
990	Osteochondrosis	1.6%
991	Pericardial effusion	1.6%
992	Pericarditis	1.6%
993	Pneumopericardium	1.6%
994	Cor pulmonale	1.6%
995	Situs Inversus	1.6%
996	Spinal Diseases	1.6%
997	Synovitis	1.6%
998	Ventricular Outflow Obstruction	1.6%
999	Joint laxity	1.6%
1000	Polyarthritis	1.6%
1001	Ventricular Dysfunction	1.6%
1002	Infantile Colic	1.6%
1003	Frozen shoulder	1.6%
1004	Patellofemoral Pain Syndrome	1.6%
1005	Cardiomyopathies	1.6%
1006	Pleuropericarditis	1.6%
1007	Gigantism	1.6%
1008	Heart Block	1.6%
1009	Spinal Neoplasms	1.6%
1010	Spondylitis	1.6%
1011	Tachycardia	1.6%
1012	Tachyarrhythmia	1.6%
1013	Adenomatous Polyposis Coli	1.6%
1014	Papillon-Lefevre Disease	1.6%
1015	Wolff-Parkinson-White Syndrome	1.6%
1016	Hypertension, Renovascular	1.6%
1017	Polyradiculopathy	1.6%
1018	Hereditary Angioedema Type III	1.6%
1019	Hereditary Angioedema Types I and II	1.6%
1020	Angina Pectoris, Variant	1.6%
1021	Congenital clubfoot	1.6%
1022	Vertical Talus	1.6%
1023	Micrognathism	1.6%
1024	Pierre Robin Syndrome	1.6%
1025	Neurofibrosarcoma	1.5%
1026	Ankylosing spondylitis	1.5%
1027	Hydrops Fetalis	1.5%
1028	Klinefelter Syndrome	1.5%
1029	Bone Diseases, Endocrine	1.5%
1030	Eye Abnormalities	1.5%
1031	Bone Diseases, Infectious	1.5%
1032	Bone neoplasms	1.5%
1033	Maxillary Diseases	1.5%
1034	Skin Abnormalities	1.5%
1035	Cardiac Output, High	1.5%
1036	Myocardial Stunning	1.5%
1037	Lymphatic Abnormalities	1.5%
1038	Low Cardiac Output Syndrome	1.5%
1039	Congenital Microtia	1.5%
1040	Anemia, Neonatal	1.5%
1041	Bone Resorption	1.5%
1042	Cardiomegaly	1.5%
1043	Hemarthrosis	1.5%
1044	Persistent Fetal Circulation Syndrome	1.5%
1045	Postpericardiotomy Syndrome	1.5%
1046	Tietze's Syndrome	1.5%
1047	Aseptic Necrosis of Bone	1.5%
1048	Cardiac Hypertrophy	1.5%
1049	Congenital diaphragmatic hernia	1.5%
1050	Aortopulmonary Septal Defect	1.5%
1051	Double Outlet Right Ventricle	1.5%
1052	Endocardial Cushion Defects	1.5%
1053	Myocardial bridging	1.5%
1054	Aorticopulmonary Septal Defect	1.5%
1055	Umbilical hernia	1.5%
1056	Rheumatic Heart Disease	1.5%
1057	Obesity, Abdominal	1.5%
1058	Amelia	1.5%
1059	Arachnodactyly	1.5%
1060	Ectopia Cordis	1.5%
1061	Ectromelia	1.5%
1062	Hemimelia	1.5%
1063	Phocomelia	1.5%
1064	Sirenomelia	1.5%
1065	Polydactyly	1.5%
1066	Brachydactyly	1.5%
1067	Plagiocephaly	1.5%
1068	Osteoarthritis, Knee	1.5%
1069	Lower Extremity Deformities, Congenital	1.5%
1070	Upper Extremity Deformities, Congenital	1.5%
1071	Single umbilical artery	1.5%
1072	Retrognathia	1.5%
1073	Brain Diseases	1.5%
1074	Postural Orthostatic Tachycardia Syndrome	1.4%
1075	Arthritis, Psoriatic	1.4%
1076	Multiple Endocrine Neoplasia Type 1	1.4%
1077	Urogenital Abnormalities	1.4%
1078	Sick Sinus Syndrome	1.4%
1079	Alexia	1.4%
1080	Dyslexia	1.4%
1081	Neonatal Abstinence Syndrome	1.4%
1082	Romano-Ward Syndrome	1.4%
1083	Fetal Growth Retardation	1.4%
1084	Fetal Hypoxia	1.4%
1085	Fetal Alcohol Spectrum Disorders	1.4%
1086	Pediatric Obesity	1.4%
1087	Syphilis, Congenital	1.3%
1088	Rheumatoid Nodule	1.3%
1089	Hepatic Vein Thrombosis	1.3%
1090	Budd-Chiari Syndrome	1.3%
1091	Esotropia	1.3%
1092	Exotropia	1.3%
1093	Sleep Apnea Syndromes	1.3%
1094	Hypertrophic Cardiomyopathy	1.3%
1095	Pulmonary Infarction	1.3%
1096	Hypertrophic obstructive cardiomyopathy	1.3%
1097	Disorders of Excessive Somnolence	1.3%
1098	Sleep Initiation and Maintenance Disorders	1.3%
1099	Night Terrors	1.3%
1100	Somnambulism	1.3%
1101	Trigeminal Nerve Disorder	1.3%
1102	Transient Insomnia	1.3%
1103	Sleep Paralysis	1.3%
1104	Chronic Insomnia	1.3%
1105	REM Sleep Behavior Disorder	1.3%
1106	Hypersomnia	1.3%
1107	Dysgeusia	1.3%
1108	Formication	1.3%
1109	Hyperalgesia	1.3%
1110	Hyperesthesia	1.3%
1111	Hypesthesia	1.3%
1112	Language Disorders	1.3%
1113	Numbness	1.3%
1114	Paresthesia	1.3%
1115	Paraparesis, Spastic	1.3%
1116	Trismus	1.3%
1117	Epilepsia Partialis Continua	1.3%
1118	Hypogeusia	1.3%
1119	Meningeal Carcinomatosis	1.3%
1120	Brown-Sequard Syndrome	1.3%
1121	Lockjaw	1.3%
1122	Allodynia	1.3%
1123	Lead Poisoning, Nervous System, Childhood	1.3%
1124	Lead Poisoning, Nervous System, Adult	1.3%
1125	Ageusia	1.3%
1126	Ascorbic Acid Deficiency	1.3%
1127	Vitamin A Deficiency	1.3%
1128	Vitamin D Deficiency	1.3%
1129	Vitamin E Deficiency	1.3%
1130	Marasmus	1.3%
1131	Giant Cell Epulis	1.3%
1132	Chorioamnionitis	1.3%
1133	Arthralgia	1.2%
1134	Polyarthralgia	1.2%
1135	Felty Syndrome	1.2%
1136	Bronchomalacia	1.2%
1137	Tracheomalacia	1.2%
1138	Carcinoid Heart Disease	1.2%
1139	Mandibulofacial Dysostosis	1.2%
1140	Eye Injuries	1.2%
1141	Diplopia	1.2%
1142	Scotoma	1.2%
1143	Photophobia	1.2%
1144	Hemifacial Spasm	1.2%
1145	Amaurosis	1.2%
1146	Blindness	1.2%
1147	Granulomatosis with polyangiitis	1.2%
1148	Agnosia	1.2%
1149	Apraxias	1.2%
1150	Hallucinations	1.2%
1151	Hemianopsia	1.2%
1152	Hyperacusis	1.2%
1153	Tinnitus	1.2%
1154	Visual Agnosia	1.2%
1155	Anosognosia	1.2%
1156	Wernicke-Korsakoff Syndrome	1.2%
1157	Phonophobia	1.2%
1158	Hearing Loss	1.2%
1159	Sarcopenia	1.2%
1160	Arthritis, Reactive	1.2%
1161	Supravalvular aortic stenosis	1.2%
1162	Lown-Ganong-Levine Syndrome	1.2%
1163	Abnormalities, Radiation-Induced	1.2%
1164	Eosinophilic Granuloma	1.2%
1165	Subacute Bacterial Endocarditis	1.2%
1166	Denys-Drash Syndrome	1.1%
1167	Truncus Arteriosus, Persistent	1.1%
1168	Amnesia	1.1%
1169	Delirium	1.1%
1170	Dissociative Amnesia	1.1%
1171	Color blindness	1.1%
1172	Global Amnesia	1.1%
1173	Meningioma	1.1%
1174	Sicca Syndrome	1.1%
1175	Sjogren's Syndrome	1.1%
1176	Ophthalmia Neonatorum	1.1%
1177	Vitamin K Deficiency	1.1%
1178	Adams-Stokes Syndrome	1.1%
1179	Atrioventricular Block	1.1%
1180	Bundle-Branch Block	1.1%
1181	Discitis	1.1%
1182	Atrial Premature Complexes	1.1%
1183	Sinoatrial Block	1.1%
1184	Tachycardia, Paroxysmal	1.1%
1185	Supraventricular tachycardia	1.1%
1186	Tachycardia, Ventricular	1.1%
1187	Tachycardia, Reciprocating	1.1%
1188	Goldenhar Syndrome	1.1%
1189	Folic Acid Deficiency	1%
1190	Pellagra	1%
1191	Thiamine Deficiency	1%
1192	Vitamin B 12 Deficiency	1%
1193	Vitamin B 6 Deficiency	1%
1194	Pyridoxine Deficiency	1%
1195	Phantom pain	1%
1196	Phantom Limb Pain	1%
1197	Spondylarthropathies	1%
1198	Tuberculosis, Spinal	1%
1199	Palatal Neoplasms	1%
1200	Ainhum	1%
1201	Aortic Valve Insufficiency	1%
1202	Bunion	1%
1203	Restrictive cardiomyopathy	1%
1204	Dysostoses	1%
1205	Endocardial Fibroelastosis	1%
1206	Heart Rupture, Post-Infarction	1%
1207	Mitral Valve Insufficiency	1%
1208	Mitral Valve Stenosis	1%
1209	Myocarditis	1%
1210	Pericarditis, Constrictive	1%
1211	Prune Belly Syndrome	1%
1212	Pulmonary Valve Insufficiency	1%
1213	Spinal Stenosis	1%
1214	Spondylosis	1%
1215	Tricuspid Valve Insufficiency	1%
1216	Tricuspid Valve Stenosis	1%
1217	Twins, Conjoined	1%
1218	Intervertebral Disc Degeneration	1%
1219	Ventricular Dysfunction, Left	1%
1220	Right Ventricular Dysfunction	1%
1221	Endomyocardial Fibrosis	1%
1222	Sacroiliitis	1%
1223	Carditis	1%
1224	Heart Failure, Systolic	1%
1225	Heart Failure, Diastolic	1%
1226	Waardenburg Syndrome	1%
1227	Beriberi	0.9%
1228	Anophthalmos	0.9%
1229	Anus, Imperforate	0.9%
1230	Arthritis, Infectious	0.9%
1231	Microphthalmos	0.9%
1232	Paralysis, Obstetric	0.9%
1233	Retinopathy of Prematurity	0.9%
1234	Anorectal Malformations	0.9%
1235	Sinus Arrhythmia	0.9%
1236	Atrial Fibrillation	0.9%
1237	Atrial Flutter	0.9%
1238	Edema, Cardiac	0.9%
1239	Osteomyelitis	0.9%
1240	Periostitis	0.9%
1241	Ventricular Fibrillation	0.9%
1242	Ventricular Flutter	0.9%
1243	Parasystole	0.9%
1244	Paroxysmal atrial fibrillation	0.9%
1245	Bradycardia	0.9%
1246	Diabetic Cardiomyopathies	0.9%
1247	Arthritis, Experimental	0.9%
1248	Alveolar Bone Loss	0.9%
1249	Bronchopulmonary Dysplasia	0.9%
1250	Cardiomyopathy, Alcoholic	0.9%
1251	Femur Head Necrosis	0.9%
1252	Sudden Cardiac Death	0.9%
1253	Left Ventricular Hypertrophy	0.9%
1254	Right Ventricular Hypertrophy	0.9%
1255	Osteolysis	0.9%
1256	Chagas Cardiomyopathy	0.9%
1257	Sleep Apnea, Obstructive	0.9%
1258	Sleep Apnea, Central	0.9%
1259	Narcolepsy	0.9%
1260	Trigeminal Neuralgia	0.9%
1261	Kleine-Levin Syndrome	0.9%
1262	Agraphia	0.9%
1263	Anomia	0.9%
1264	Cluttering	0.9%
1265	Language Development Disorders	0.9%
1266	Speech Disorders	0.9%
1267	Syncope	0.9%
1268	Stupor	0.9%
1269	Dysgraphia	0.9%
1270	Presyncope	0.9%
1271	Dyslalia	0.9%
1272	Anemia, Pernicious	0.8%
1273	Blepharophimosis	0.8%
1274	Hip Dislocation	0.8%
1275	Laryngostenosis	0.8%
1276	Mouth Abnormalities	0.8%
1277	Respiratory Distress Syndrome, Newborn	0.8%
1278	Shoulder Dislocation	0.8%
1279	Hip Dysplasia	0.8%
1280	Esophageal Atresia	0.8%
1281	Intestinal Atresia	0.8%
1282	Horseshoe Kidney	0.8%
1283	Acrodermatitis	0.8%
1284	Lymphangiectasis, Intestinal	0.8%
1285	Gianotti-Crosti Syndrome	0.8%
1286	Dyspnea, Paroxysmal	0.8%
1287	Eye Burns	0.8%
1288	Joint Tuberculosis	0.8%
1289	Tuberculosis, Osteoarticular	0.8%
1290	Bone Tuberculosis	0.8%
1291	Amaurosis Fugax	0.8%
1292	Blindness, Cortical	0.8%
1293	Dyscalculia	0.8%
1294	Deafness	0.8%
1295	Hearing Loss, Sudden	0.8%
1296	Gerstmann Syndrome	0.8%
1297	Hearing Loss, Bilateral	0.8%
1298	Hearing Loss, High-Frequency	0.8%
1299	Hearing Loss, Mixed Conductive-Sensorineural	0.8%
1300	Prosopagnosia	0.8%
1301	Apraxia, Ideomotor	0.8%
1302	Charles Bonnet Syndrome	0.8%
1303	Hearing Loss, Unilateral	0.8%
1304	Complete Hearing Loss	0.8%
1305	Alien Hand Syndrome	0.8%
1306	Deaf Mutism	0.8%
1307	Tachycardia, Atrioventricular Nodal Reentry	0.8%
1308	Tachycardia, Ectopic Atrial	0.8%
1309	Tachycardia, Ectopic Junctional	0.8%
1310	Sinus Tachycardia	0.8%
1311	Torsades de Pointes	0.8%
1312	Accelerated Idioventricular Rhythm	0.8%
1313	Choanal Atresia	0.8%
1314	Tracheobronchomegaly	0.8%
1315	Laryngocele	0.8%
1316	Choledochal Cyst	0.8%
1317	Hermaphroditism	0.8%
1318	Disorders of Sex Development	0.8%
1319	Cryptorchidism	0.8%
1320	Hypospadias	0.8%
1321	Corneal Scar	0.7%
1322	Retrograde amnesia	0.7%
1323	Amnesia, Anterograde	0.7%
1324	Shoulder Pain	0.7%
1325	Bladder Exstrophy	0.7%
1326	Epispadias	0.7%
1327	Multicystic Dysplastic Kidney	0.7%
1328	Cataplexy	0.7%
1329	Aphasia	0.7%
1330	Articulation Disorders	0.7%
1331	Echolalia	0.7%
1332	Stuttering	0.7%
1333	Dysphasia	0.7%
1334	Aortic Valve Prolapse	0.6%
1335	Chondrodysplasia Punctata	0.6%
1336	Enchondromatosis	0.6%
1337	Lordosis	0.6%
1338	Osteosclerosis	0.6%
1339	Spondylolysis	0.6%
1340	Tricuspid Valve Prolapse	0.6%
1341	Takotsubo Cardiomyopathy	0.6%
1342	kyphosis	0.6%
1343	Kashin-Beck Disease	0.6%
1344	Mutism	0.6%
1345	Selective Mutism	0.6%
1346	Sinus Arrest, Cardiac	0.6%
1347	Hyperandrogenism	0.6%
1348	Corneal Perforation	0.6%
1349	Dysarthria	0.5%
1350	Dental Enamel Hypoplasia	0.5%
1351	Hyaline Membrane Disease	0.5%
1352	Hypodontia	0.5%
1353	Macrostomia	0.5%
1354	Microstomia	0.5%
1355	Mastoiditis	0.5%
1356	Petrositis	0.5%
1357	Alexia, Pure	0.5%
1358	Gonadal Dysgenesis	0.5%
1359	Adrenogenital Syndrome	0.5%
1360	Ovotesticular Disorders of Sex Development	0.5%
1361	Melorheostosis	0.5%
1362	Osteopetrosis	0.5%
1363	Spondylolisthesis	0.5%
1364	Nose Neoplasms	0.4%
1365	Radicular Cyst	0.3%

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