MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hypertensive Encephalopathy

(UMLS:C0151620)

Definition:: Brain dysfunction or damage resulting from sustained MALIGNANT HYPERTENSION. When BLOOD PRESSURE exceeds the limits of cerebral autoregulation, cerebral blood flow is impaired (BRAIN ISCHEMIA). Clinical manifestations include HEADACHE; NAUSEA; VOMITING; SEIZURES; altered mental status (in some cases progressing to COMA); PAPILLEDEMA; and RETINAL HEMORRHAGE.
UMLS ID:: C0151620
MeSH ID:: D020343

Classification:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.631.500

Synonym(s)

Hypertensive Encephalopathy

ENCEPHALOPATHY HYPERTENSIVE

HYPERTENSIVE ENCEPHALOPATHY

Hypertensive encephalopathy

Hypertensive encephalopathy syndrome

encephalopathy hypertensive

encephalopathy; hypertensive

hypertensive encephalopathy

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Cyclosporine	FAERS: 11		US FAERS
2	Methylergonovine	FAERS: 6		US FAERS
3	Tacrolimus	FAERS: 6		US FAERS
4	rofecoxib	FAERS: 6		US FAERS
5	Gabapentin	FAERS: 4		US FAERS
6	Sunitinib	FAERS: 4		US FAERS
7	Axitinib	FAERS: 3		US FAERS
8	Clozapine	FAERS: 3		US FAERS
9	Dasatinib	FAERS: 3		US FAERS
10	Duloxetine Hydrochloride	FAERS: 3		US FAERS
11	Ivermectin	FAERS: 3		US FAERS
12	Rosiglitazone	FAERS: 3		US FAERS
13	Sorafenib	FAERS: 3		US FAERS
14	Acitretin	FAERS: 2		US FAERS
15	Bortezomib	FAERS: 2		US FAERS
16	Clobetasol	FAERS: 2		US FAERS
17	Lenalidomide	FAERS: 2 Canada Vigilance: 2		Canada Vigilance US FAERS
18	Ondansetron	FAERS: 2		US FAERS
19	Venlafaxine Hydrochloride	FAERS: 2		US FAERS
20	pazopanib	FAERS: 2		US FAERS
21	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1		US FAERS
22	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination	FAERS: 1		US FAERS
23	Baclofen	FAERS: 1		US FAERS
24	Carbamazepine	FAERS: 1	11836887	CTD US FAERS
25	Cinacalcet	FAERS: 1		US FAERS
26	Clonidine	FAERS: 1		US FAERS
27	Cyclophosphamide	FAERS: 1		US FAERS
28	Deamino Arginine Vasopressin	FAERS: 1	17893586	CTD US FAERS
29	Everolimus	FAERS: 1		US FAERS
30	Goserelin	FAERS: 1		US FAERS
31	Ifosfamide	FAERS: 1		US FAERS
32	Lamotrigine	FAERS: 1		US FAERS
33	Nicardipine	FAERS: 1		US FAERS
34	Nicotine	FAERS: 1		US FAERS
35	NuvaRing	FAERS: 1		US FAERS
36	Olmesartan Medoxomil	FAERS: 1		US FAERS
37	Quetiapine Fumarate	FAERS: 1		US FAERS
38	Sunitinib	FAERS: 1		US FAERS
39	benazepril	FAERS: 1		US FAERS
40	carfilzomib	FAERS: 1		US FAERS
41	eletriptan	FAERS: 1		US FAERS
42	gemcitabine	FAERS: 1		US FAERS
43	lenvatinib	FAERS: 1		US FAERS
44	palbociclib	FAERS: 1		US FAERS
45	pazopanib	FAERS: 1		US FAERS
46	regorafenib	FAERS: 1		US FAERS
47	Caffeine		16956868	CTD
48	Cocaine		1927636	CTD
49	Dexamethasone		1537356 17557962	CTD
50	Dobutamine		10232545	CTD
51	Ephedrine		16956868	CTD
52	Labetalol		115540	CTD
53	Phenytoin		11836887	CTD
54	Pseudoephedrine		20398975	CTD
55	Resveratrol		21054406	CTD
56	valdecoxib			SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Pseudotumor Cerebri	48.4%
2	Akinetic Mutism	34.4%
3	Anoxic Encephalopathy	34.4%
4	Basal Ganglia Diseases	34.4%
5	Brain Damage, Chronic	34.4%
6	Cerebellar Diseases	34.4%
7	Encephalitis	34.4%
8	Encephalomalacia	34.4%
9	Epilepsy	34.4%
10	Hydrocephalus	34.4%
11	Congenital Hydrocephalus	34.4%
12	Hypothalamic Diseases	34.4%
13	Thalamic Diseases	34.4%
14	Aura	34.4%
15	Leukoencephalopathy	34.4%
16	Neuroaxonal Dystrophies	34.4%
17	Headache Disorders	34.4%
18	Intracranial Hypotension	34.4%
19	Brain Edema	34.4%
20	Brain Hypoxia	34.4%
21	Aqueductal Stenosis	34.4%
22	Subdural Effusion	29.3%
23	Encephalomyelitis	27%
24	Meningitis	25.4%
25	Movement Disorders	25.4%
26	Pachymeningitis	25.4%
27	Spinal Cord Diseases	25.4%
28	Parkinsonian Disorders	25%
29	Meningoencephalitis	24.8%
30	Brain Diseases, Metabolic	23.6%
31	Cerebrovascular Disorders	23.6%
32	Cerebrovascular Insufficiency	23.6%
33	Dementia	23.6%
34	Basal Ganglia Cerebrovascular Disease	22.8%
35	Cerebral Palsy	22.6%
36	Epilepsies, Partial	22.6%
37	Epilepsy, Generalized	22.6%
38	Simple Partial Seizures	22.6%
39	Epilepsy, Reflex	22.6%
40	Headache Disorders, Primary	22.6%
41	Headache Disorders, Secondary	22.6%
42	Medication overuse headache	22.6%
43	Myoclonic Epilepsy	22.3%
44	Epilepsy, Temporal Lobe	22.3%
45	Epilepsy, Rolandic	22.3%
46	Benign Rolandic Epilepsy	22.3%
47	Dandy-Walker Syndrome	21.9%
48	Meige Syndrome	21.5%
49	Cerebral Ventriculitis	21.5%
50	Marchiafava-Bignami Disease	21.1%
51	Multiple System Atrophy	20.7%
52	Dementia, Vascular	20.4%
53	Pneumocephalus	20.4%
54	Brain Abscess	20%
55	Vascular Headaches	19.8%
56	Brain Injuries	19.8%
57	Myelitis	19.8%
58	Hypoxia-Ischemia, Brain	19.7%
59	Brain Neoplasms	19.7%
60	Lewy Body Disease	19.5%
61	Epilepsy, Post-Traumatic	19.4%
62	Juvenile Myoclonic Epilepsy	18.5%
63	Myoclonic Epilepsies, Progressive	18.5%
64	Leukomalacia, Periventricular	18.3%
65	Brain Death	18.1%
66	Central Nervous System Infection	18.1%
67	Ocular Motility Disorders	18%
68	Cyclophoria	18%
69	Parkinson Disease	17.7%
70	Post-Traumatic Headache	16.8%
71	Tension Headache	16.8%
72	Epilepsy, Complex Partial	16.8%
73	Migraine Disorders	16.8%
74	Abdominal Migraine	16.8%
75	Status Migrainosus	16.8%
76	Cervicogenic Headache	16.8%
77	Cerebellar Neoplasms	16.6%
78	Cranial nerve diseases	16.4%
79	Demyelinating Diseases	16.4%
80	Demyelination	16.4%
81	Neuromuscular Diseases	16.4%
82	Chronobiology Disorders	16.4%
83	Pituitary Diseases	16.3%
84	Creutzfeldt-Jakob disease	16.3%
85	Neuroleptic Malignant Syndrome	15.8%
86	Myelinolysis, Central Pontine	15.8%
87	Prion Diseases	15.7%
88	Epidural Abscess	15.7%
89	Carotid Artery Diseases	15.2%
90	Brain Ischemia	15.2%
91	Cerebrovascular accident	15.2%
92	Kluver-Bucy Syndrome	15.2%
93	Vasospasm, Intracranial	15.2%
94	Intracranial Arterial Diseases	15.2%
95	Amblyopia	15.2%
96	Dystonia Musculorum Deformans	15%
97	Posterior Leukoencephalopathy Syndrome	15%
98	Posterior reversible encephalopathy syndrome	15%
99	Arachnoiditis	14.8%
100	Aseptic Meningitis	14.8%
101	Syringomyelia	14.8%
102	Essential Tremor	14.8%
103	Familial Tremor	14.8%
104	Pneumorrhachis	14.8%
105	Writer's Cramp	14.8%
106	Huntington Disease	14.5%
107	Cluster Headache	13.9%
108	Migraine with Aura	13.9%
109	Familial Hemiplegic Migraine	13.9%
110	Chronic Paroxysmal Hemicrania	13.9%
111	SUNCT Syndrome	13.9%
112	Paroxysmal Hemicrania	13.9%
113	Presenile dementia	13.9%
114	Senile dementia	13.9%
115	Striatonigral Degeneration	13.9%
116	Pituitary Apoplexy	13.7%
117	Basal Ganglia Hemorrhage	13.5%
118	Brain Infarction	13.5%
119	Stiff-Person Syndrome	12.9%
120	Brain Injuries, Diffuse	12.9%
121	Traumatic Brain Injury	12.9%
122	Cerebellar Ataxia	12.9%
123	Supratentorial Neoplasms	12.9%
124	Limbic Encephalitis	12.5%
125	Spinal Muscular Atrophy	12.4%
126	Progressive Muscular Atrophy	12.4%
127	Spinal Cord Injuries	12.4%
128	Persistent Vegetative State	12.4%
129	Meningitis, Bacterial	12.3%
130	Meningitis, Fungal	12.3%
131	Progressive supranuclear palsy	12.2%
132	Leukoencephalopathy, Progressive Multifocal	12.2%
133	Amnesia, Transient Global	12.1%
134	Lafora Disease	12.1%
135	Unverricht-Lundborg Syndrome	12.1%
136	MPTP Poisoning	12%
137	Asterixis	11.8%
138	Ballismus	11.8%
139	Shy-Drager Syndrome	11.7%
140	Empty Sella Syndrome	11.6%
141	Hyperpituitarism	11.6%
142	Hypopituitarism	11.6%
143	Hypophysitis	11.6%
144	Motor Neuron Disease	11.5%
145	Reye Syndrome	11.5%
146	Putaminal Hemorrhage	11.5%
147	Trauma, Nervous System	11.4%
148	Intracranial Embolism and Thrombosis	11.4%
149	Hepatic Encephalopathy	11.4%
150	Pituitary Adenoma	11.3%
151	Pituitary Neoplasms	11.3%
152	Cerebral Arterial Diseases	11.2%
153	Vertebrobasilar Insufficiency	11.2%
154	Basilar Artery Stenosis	11.2%
155	Vertebral Artery Stenosis	11.2%
156	Intracranial Hemorrhage, Hypertensive	11.2%
157	Transient Cerebral Ischemia	11.2%
158	Poliomyelitis	11.2%
159	Cerebral Infarction	11.1%
160	Carotid Artery Injuries	11.1%
161	Paraneoplastic Cerebellar Degeneration	11.1%
162	Brain Stem Infarctions	11.1%
163	Infarction, Middle Cerebral Artery	11.1%
164	Infarction, Anterior Cerebral Artery	11.1%
165	Infarction, Posterior Cerebral Artery	11.1%
166	Lupus Vasculitis, Central Nervous System	10.9%
167	Nervous System Neoplasms	10.8%
168	Neurologic Manifestations	10.8%
169	Neurotoxicity Syndromes	10.8%
170	Encephalomyelitis, Acute Disseminated	10.7%
171	Brain Hemorrhage, Traumatic	10.7%
172	Subacute Combined Degeneration	10.6%
173	Vasculitis, Central Nervous System	10.6%
174	Leukoencephalitis, Acute Hemorrhagic	10.5%
175	Moyamoya Disease	10.3%
176	Central Nervous System Fungal Infections	10.1%
177	Conus Medullaris Syndrome	10.1%
178	Spinal Cord Vascular Diseases	10.1%
179	Friedreich Ataxia	10%
180	Hepatolenticular Degeneration	10%
181	Lateral Medullary Syndrome	10%
182	Chronic Fatigue Syndrome	9.9%
183	Toxoplasmosis, Cerebral	9.9%
184	Amyotrophic Lateral Sclerosis	9.9%
185	Spinal Cord Neoplasms	9.8%
186	Diffuse Axonal Injury	9.6%
187	Brain Stem Neoplasms	9.5%
188	Hyperprolactinemia	9.4%
189	Ophthalmoplegic Migraine	9.4%
190	Subclavian Steal Syndrome	9.3%
191	Pick Disease of the Brain	9.3%
192	Brain Diseases, Metabolic, Inborn	9.2%
193	Canavan Disease	9.1%
194	Alexander Disease	9.1%
195	Autonomic Dysreflexia	9%
196	Complex Regional Pain Syndromes	9%
197	Miller Fisher Syndrome	8.8%
198	Mitochondrial Encephalomyopathies	8.7%
199	Carotid Stenosis	8.5%
200	Intracranial Aneurysm	8.5%
201	Dysautonomia	8.5%
202	Vagus Nerve Disorder	8.5%
203	Glossopharyngeal Neuralgia	8.5%
204	Abducens Nerve Diseases	8.5%
205	Heavy Metal Poisoning, Nervous System	8.5%
206	Neuromuscular Junction Diseases	8.5%
207	Tauopathies	8.5%
208	Trochlear Nerve Diseases	8.5%
209	Peripheral Nervous System Diseases	8.5%
210	Intracranial Arteriosclerosis	8.4%
211	Cerebral Atherosclerosis	8.4%
212	Subarachnoid Hemorrhage	8.4%
213	Cerebral Arteriosclerosis	8.4%
214	Cerebral Hemorrhage	8.4%
215	Cerebral Thrombosis	8.4%
216	Intracranial Embolism	8.4%
217	Intracranial Thrombosis	8.4%
218	Sleep Wake Disorders	8.3%
219	Polyradiculoneuropathy	8.1%
220	Polyradiculoneuritis	8.1%
221	Frontotemporal dementia	8%
222	Tuberculosis, Meningeal	8%
223	Choroid Plexus Papilloma	7.9%
224	Restless Legs Syndrome	7.9%
225	Akathisia, Drug-Induced	7.8%
226	Subarachnoid Hemorrhage, Traumatic	7.8%
227	Carotid Artery, Internal, Dissection	7.8%
228	Brain Contusion	7.7%
229	Central Nervous System Bacterial Infections	7.7%
230	Myelitis, Transverse	7.6%
231	Wernicke Encephalopathy	7.6%
232	AIDS Dementia Complex	7.6%
233	Scrapie	7.5%
234	Central Cord Syndrome	7.5%
235	Auditory Perceptual Disorders	7.4%
236	Chorea	7.3%
237	Vertebral Artery Dissection	7.3%
238	Subacute Sclerosing Panencephalitis	7.3%
239	MELAS Syndrome	7.2%
240	Acromegaly	7.1%
241	Opsoclonus-Myoclonus Syndrome	7.1%
242	Cerebral Amyloid Angiopathy	7%
243	Sinus Thrombosis, Intracranial	6.9%
244	Peripheral Nerve Injuries	6.8%
245	Meningitis, Cryptococcal	6.8%
246	Meningitis, Listeria	6.8%
247	Carotid Artery Thrombosis	6.7%
248	Meningitis, Haemophilus	6.7%
249	Meningitis, Pneumococcal	6.7%
250	Myasthenia Gravis	6.7%
251	Dyskinesia, Drug-Induced	6.7%
252	Kernicterus	6.7%
253	Progressive bulbar palsy	6.6%
254	Bulbar palsy	6.6%
255	Spinal Cord Ischemia	6.5%
256	Adrenoleukodystrophy	6.5%
257	Brain Concussion	6.4%
258	Torticollis	6.4%
259	Tuberculosis, Central Nervous System	6.4%
260	Ataxia Telangiectasia	6.3%
261	Cavernous Sinus Thrombosis	6.2%
262	Sagittal Sinus Thrombosis	6.2%
263	Myopathy	6%
264	Optic Neuropathy	6%
265	Alice in Wonderland Syndrome	5.9%
266	Facial Nerve Diseases	5.7%
267	Craniocerebral Trauma	5.7%
268	Parasomnia	5.7%
269	Dyssomnias	5.7%
270	Guillain-Barre Syndrome	5.7%
271	Causalgia	5.7%
272	Vestibulocochlear Nerve Diseases	5.6%
273	Decerebrate State	5.6%
274	Hemiparesis	5.6%
275	Hydranencephaly	5.6%
276	Meningism	5.6%
277	Neural Tube Defects	5.6%
278	Paresis	5.6%
279	Seizures	5.6%
280	Sensation Disorders	5.6%
281	Tethered Cord Syndrome	5.6%
282	Central Nervous System Neoplasms	5.6%
283	Complex partial seizures	5.6%
284	Iniencephaly	5.6%
285	Craniorachischisis	5.6%
286	Exencephaly	5.6%
287	Monoparesis	5.6%
288	Septo-Optic Dysplasia	5.6%
289	Cortical Dysplasia	5.6%
290	Neurogenic Inflammation	5.6%
291	Gait Disorders, Neurologic	5.6%
292	Neuromuscular Manifestations	5.6%
293	Malformations of Cortical Development	5.6%
294	Sleep Disorders, Circadian Rhythm	5.6%
295	Sweating, Gustatory	5.6%
296	Auriculotemporal Syndrome	5.6%
297	West Nile Fever	5.5%
298	Giant Cell Arteritis	5.5%
299	Temporal Arteritis	5.5%
300	Reflex Sympathetic Dystrophy	5.4%
301	Nocturnal Myoclonus Syndrome	5.4%
302	Botulism	5.3%
303	Central Nervous System Cysts	5.3%
304	Lambert-Eaton Myasthenic Syndrome	5.2%
305	Olfactory Nerve Injuries	5.2%
306	Tardive Dyskinesia	5.2%
307	Nelson Syndrome	5%
308	Hematoma, Subdural	4.9%
309	Hematoma, Epidural, Cranial	4.9%
310	Multiple Sclerosis	4.9%
311	Neuritis	4.9%
312	Polyneuritis	4.9%
313	Radiculitis	4.9%
314	Polyneuropathy	4.9%
315	Mononeuritis	4.9%
316	Mononeuropathies	4.9%
317	Brachial Plexus Neuropathies	4.9%
318	Radiculopathy	4.9%
319	Mononeuropathy Multiplex	4.9%
320	Nerve Root Compression	4.9%
321	Neuroaspergillosis	4.9%
322	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	4.9%
323	Galactosemias	4.8%
324	Urea Cycle Disorders, Inborn	4.8%
325	Tyrosinemias	4.8%
326	Anterior Spinal Artery Syndrome	4.8%
327	Prolactinoma	4.7%
328	Growth Hormone-Secreting Pituitary Adenoma	4.7%
329	Horner Syndrome	4.6%
330	Refsum Disease	4.6%
331	Fabry Disease	4.5%
332	Pupil Disorders	4.4%
333	Neurobehavioral Manifestations	4.4%
334	Facial Nerve Injuries	4.4%
335	Neuromyelitis Optica	4.3%
336	Brachial Plexus Neuritis	4.3%
337	Neuralgic Amyotrophy	4.3%
338	Paraneoplastic Encephalomyelitis	4.3%
339	Homocystinuria	4.3%
340	Hematoma, Subdural, Intracranial	4.2%
341	Hematoma, Subdural, Chronic	4.2%
342	Hematoma, Subdural, Acute	4.2%
343	Leigh Disease	4.2%
344	Uveomeningoencephalitic Syndrome	4.2%
345	Pseudorabies	4.2%
346	Sturge-Weber Syndrome	4.2%
347	Vertigo	4.2%
348	Alcohol-Induced Disorders, Nervous System	4.2%
349	Acrodynia	4%
350	Ophthalmoplegia	4%
351	External Ophthalmoplegia	4%
352	Neurosyphilis	3.9%
353	Jet Lag Syndrome	3.9%
354	Tarsal Tunnel Syndrome	3.7%
355	Cauda Equina Syndrome	3.7%
356	Myasthenia Gravis, Autoimmune, Experimental	3.7%
357	Toxoplasmosis, Congenital	3.7%
358	Malaria, Cerebral	3.7%
359	Neurocysticercosis	3.6%
360	Menkes Kinky Hair Syndrome	3.5%
361	Charcot-Marie-Tooth Disease	3.5%
362	Carbamoyl-Phosphate Synthase I Deficiency Disease	3.5%
363	Coma, Post-Head Injury	3.5%
364	Voice Disorders	3.4%
365	Voice Disturbance	3.4%
366	Tuberous Sclerosis	3.4%
367	Myositis	3.4%
368	Optic Atrophy	3.4%
369	Optic Neuritis	3.4%
370	Papilledema	3.4%
371	Strabismus	3.4%
372	Tolosa-Hunt Syndrome	3.4%
373	Vocal Cord Paralysis	3.4%
374	Isaacs syndrome	3.4%
375	Arsenic Poisoning	3.4%
376	Myotonic Disorders	3.4%
377	Myasthenic Syndromes, Congenital	3.4%
378	Smith-Magenis syndrome	3.4%
379	Dural Arteriovenous Fistula	3.3%
380	Diabetic Neuropathies	3.3%
381	Facial Injuries	3.3%
382	Facial Neuralgia	3.3%
383	Diabetic Amyotrophy	3.3%
384	Diabetic Autonomic Neuropathy	3.3%
385	Sleep Talking	3.3%
386	Manganese Poisoning	3.3%
387	Sleep Disorders, Intrinsic	3.3%
388	Orthostatic intolerance	3.3%
389	Myotonia Congenita	3.3%
390	Anosmia	3.3%
391	Ataxia	3.3%
392	Athetosis	3.3%
393	Catalepsy	3.3%
394	Dystonia	3.3%
395	Hemiplegia	3.3%
396	Locked-In Syndrome	3.3%
397	Meningeal Neoplasms	3.3%
398	Meningomyelocele	3.3%
399	Muscle Hypertonia	3.3%
400	Muscle hypotonia	3.3%
401	Myoclonus	3.3%
402	Myotonia	3.3%
403	Neuralgia	3.3%
404	Paraplegia	3.3%
405	Pseudobulbar Palsy	3.3%
406	Quadriplegia	3.3%
407	Spasm	3.3%
408	Spastic Paraplegia	3.3%
409	Status Epilepticus	3.3%
410	Taste Disorders	3.3%
411	Tremor	3.3%
412	Spina Bifida	3.3%
413	Monoplegia	3.3%
414	Hypokinesia	3.3%
415	Paraparesis	3.3%
416	Bradykinesia	3.3%
417	Waxy flexibility	3.3%
418	Action Tremor	3.3%
419	Resting Tremor	3.3%
420	Dysosmia	3.3%
421	Quadriparesis	3.3%
422	Mercury Poisoning, Nervous System	3.3%
423	Olfaction Disorders	3.3%
424	Myokymia	3.3%
425	Lead Poisoning, Nervous System	3.3%
426	Vestibular Neuronitis	3.3%
427	Somatosensory Disorders	3.3%
428	Neuropathic pain	3.3%
429	Hyperkinesia	3.3%
430	Intention tremor	3.3%
431	Cerebrospinal Fluid Otorrhea	3.2%
432	Cerebrospinal Fluid Rhinorrhea	3.2%
433	Neuritis, Autoimmune, Experimental	3.2%
434	Gait Ataxia	3.2%
435	Sciatic Neuropathy	3.2%
436	Ulnar Neuropathies	3.2%
437	Lesion of Sciatic Nerve	3.2%
438	Ulnar Neuritis	3.2%
439	Radial nerve compression	3.2%
440	Radial Tunnel Syndrome	3.2%
441	Peroneal Neuropathies	3.2%
442	Radial Neuropathy	3.2%
443	Median Neuropathy	3.2%
444	Sciatic Nerve Palsy	3.2%
445	Femoral Neuropathy	3.2%
446	Tibial Neuropathy	3.2%
447	Ulnar Nerve Palsy	3.2%
448	Postural Orthostatic Tachycardia Syndrome	3.2%
449	Radial nerve palsy	3.2%
450	Lyme Neuroborreliosis	3.2%
451	Multiple Sclerosis, Chronic Progressive	3.2%
452	Multiple Sclerosis, Relapsing-Remitting	3.2%
453	Zellweger Syndrome	3.1%
454	Glycogen storage disease type II	3.1%
455	Carpal Tunnel Syndrome	2.8%
456	neurofibroma	2.8%
457	Sciatica	2.8%
458	Alcohol Withdrawal Seizures	2.8%
459	Reflex, Abnormal	2.7%
460	Hyporeflexia	2.7%
461	Hyperreflexia	2.7%
462	Akathisia	2.7%
463	Restlessness	2.7%
464	Psychomotor Agitation	2.7%
465	Myotonic Dystrophy	2.7%
466	Waterhouse-Friderichsen Syndrome	2.7%
467	Hand-Arm Vibration Syndrome	2.7%
468	Vision Disorders	2.6%
469	Metamorphopsia	2.6%
470	Visual Impairment	2.6%
471	Fibromyalgia	2.6%
472	Optic Neuropathy, Ischemic	2.6%
473	Anterior Ischemic Optic Neuropathy	2.6%
474	Medial Tibial Stress Syndrome	2.6%
475	Facial Hemiatrophy	2.5%
476	Melkersson-Rosenthal Syndrome	2.5%
477	Mitochondrial Myopathies	2.5%
478	Anisocoria	2.5%
479	Confusion	2.5%
480	Facial paralysis	2.5%
481	Lethargy	2.5%
482	Memory Disorders	2.5%
483	Muscle Cramp	2.5%
484	Perceptual Disorders	2.5%
485	Psychomotor Disorders	2.5%
486	Tonic Pupil	2.5%
487	Eosinophilia-Myalgia Syndrome	2.5%
488	Anhedonia	2.5%
489	Disorientation	2.5%
490	Facial Paresis	2.5%
491	Memory Loss	2.5%
492	Hemisensory Neglect	2.5%
493	Dysacusis	2.5%
494	Gaucher Disease	2.5%
495	Sleep Bruxism	2.5%
496	Anencephaly	2.5%
497	Meningocele	2.5%
498	Muscular Atrophy	2.5%
499	Respiratory Paralysis	2.5%
500	Encephalocele	2.5%
501	Tetany	2.4%
502	Gait Apraxia	2.4%
503	Polyradiculopathy	2.4%
504	Cubital Tunnel Syndrome	2.4%
505	Tay-Sachs Disease	2.3%
506	Thoracic Outlet Syndrome	2.2%
507	Optic Nerve Glioma	2.2%
508	Esotropia	2.2%
509	Exotropia	2.2%
510	Hypotension, Orthostatic	2.2%
511	Sleep Apnea Syndromes	2.2%
512	Polymyositis	2.2%
513	Post-Exercise Hypotension	2.2%
514	Disorders of Excessive Somnolence	2.2%
515	Sleep Initiation and Maintenance Disorders	2.2%
516	Night Terrors	2.2%
517	Somnambulism	2.2%
518	Trigeminal Nerve Disorder	2.2%
519	Transient Insomnia	2.2%
520	Sleep Paralysis	2.2%
521	Chronic Insomnia	2.2%
522	REM Sleep Behavior Disorder	2.2%
523	Hypersomnia	2.2%
524	Dermal Sinus	2.1%
525	Dysgeusia	2.1%
526	Formication	2.1%
527	Hyperalgesia	2.1%
528	Hyperesthesia	2.1%
529	Hypesthesia	2.1%
530	Language Disorders	2.1%
531	Numbness	2.1%
532	Paresthesia	2.1%
533	Paraparesis, Spastic	2.1%
534	Spina Bifida Cystica	2.1%
535	Trismus	2.1%
536	Spina Bifida Occulta	2.1%
537	Epilepsia Partialis Continua	2.1%
538	Hypogeusia	2.1%
539	Meningeal Carcinomatosis	2.1%
540	Brown-Sequard Syndrome	2.1%
541	Lissencephaly	2.1%
542	Polymicrogyria	2.1%
543	Pachygyria	2.1%
544	Schizencephaly	2.1%
545	Lockjaw	2.1%
546	Allodynia	2.1%
547	Lead Poisoning, Nervous System, Childhood	2.1%
548	Lead Poisoning, Nervous System, Adult	2.1%
549	Periventricular Nodular Heterotopia	2.1%
550	Ageusia	2.1%
551	Niemann-Pick Disease, Type C	2.1%
552	Alstrom Syndrome	2.1%
553	Duane Retraction Syndrome	2%
554	Consciousness Disorders	2%
555	Mental Retardation	2%
556	Muscle Weakness	2%
557	Depressed Level of Consciousness	2%
558	Mental deficiency	2%
559	Intellectual Disability	2%
560	Amyloid Neuropathies, Familial	2%
561	Mobius Syndrome	2%
562	Bell Palsy	2%
563	Catatonia	2%
564	Herpes Zoster Oticus	2%
565	Familial Periodic Paralysis	2%
566	Aphonia	2%
567	Sleep Deprivation	2%
568	Dysphonia	2%
569	Acoustic Neuroma	1.9%
570	Classical Lissencephalies and Subcortical Band Heterotopias	1.9%
571	Eye Injuries	1.7%
572	Muscular Dystrophy	1.7%
573	Congenital nystagmus	1.7%
574	Orbital Myositis	1.7%
575	Diplopia	1.6%
576	Muscle Rigidity	1.6%
577	Muscle Spasticity	1.6%
578	Scotoma	1.6%
579	Photophobia	1.6%
580	Cogwheel Rigidity	1.6%
581	Hemifacial Spasm	1.6%
582	Amaurosis	1.6%
583	Blindness	1.6%
584	Nuchal Rigidity	1.6%
585	Myalgia	1.6%
586	Pyomyositis	1.6%
587	Neuronal Ceroid-Lipofuscinoses	1.6%
588	Agnosia	1.6%
589	Apraxias	1.6%
590	Hallucinations	1.6%
591	Hemianopsia	1.6%
592	Hyperacusis	1.6%
593	Tinnitus	1.6%
594	Visual Agnosia	1.6%
595	Anosognosia	1.6%
596	Wernicke-Korsakoff Syndrome	1.6%
597	Phonophobia	1.6%
598	Hearing Loss	1.6%
599	Sarcopenia	1.6%
600	Sleep Apnea, Obstructive	1.6%
601	Sleep Apnea, Central	1.6%
602	Alexia	1.6%
603	Dyslexia	1.6%
604	Narcolepsy	1.6%
605	Trigeminal Neuralgia	1.6%
606	Kleine-Levin Syndrome	1.6%
607	Agraphia	1.6%
608	Anomia	1.6%
609	Cluttering	1.6%
610	Language Development Disorders	1.6%
611	Speech Disorders	1.6%
612	Syncope	1.6%
613	Stupor	1.6%
614	Dysgraphia	1.6%
615	Presyncope	1.6%
616	Dyslalia	1.6%
617	Neurofibrosarcoma	1.5%
618	Aicardi's syndrome	1.4%
619	Hoarseness	1.4%
620	Optic Atrophy, Hereditary, Leber	1.4%
621	Cockayne Syndrome	1.4%
622	Alcohol Withdrawal Delirium	1.4%
623	Cataplexy	1.3%
624	Aphasia	1.3%
625	Articulation Disorders	1.3%
626	Echolalia	1.3%
627	Stuttering	1.3%
628	Dysphasia	1.3%
629	Amnesia	1.3%
630	Delirium	1.3%
631	Dissociative Amnesia	1.3%
632	Color blindness	1.3%
633	Global Amnesia	1.3%
634	Cri-du-Chat Syndrome	1.3%
635	Down Syndrome	1.3%
636	Trisomy 21	1.3%
637	Kearns-Sayre syndrome	1.3%
638	POEMS Syndrome	1.3%
639	Meningioma	1.3%
640	Williams Syndrome	1.3%
641	Microcephaly	1.3%
642	Macrocephaly	1.3%
643	Hypokalemic periodic paralysis	1.3%
644	Porencephaly	1.3%
645	Holoprosencephaly	1.2%
646	Eye Burns	1.2%
647	Welander Distal Myopathy	1.2%
648	Amaurosis Fugax	1.2%
649	Blindness, Cortical	1.2%
650	Dyscalculia	1.2%
651	Rett Syndrome	1.2%
652	Deafness	1.2%
653	Hearing Loss, Sudden	1.2%
654	Gerstmann Syndrome	1.2%
655	Hearing Loss, Bilateral	1.2%
656	Hearing Loss, High-Frequency	1.2%
657	Hearing Loss, Mixed Conductive-Sensorineural	1.2%
658	Prosopagnosia	1.2%
659	Apraxia, Ideomotor	1.2%
660	Charles Bonnet Syndrome	1.2%
661	Hearing Loss, Unilateral	1.2%
662	Complete Hearing Loss	1.2%
663	Alien Hand Syndrome	1.2%
664	Deaf Mutism	1.2%
665	Dysarthria	1.2%
666	Prader-Willi Syndrome	1.1%
667	Phantom pain	1.1%
668	Phantom Limb Pain	1.1%
669	Mutism	1%
670	Selective Mutism	1%
671	Dermatomyositis	1%
672	Corneal Scar	1%
673	Muscular Dystrophy, Duchenne	1%
674	Retrograde amnesia	1%
675	Amnesia, Anterograde	1%
676	Alexia, Pure	0.9%
677	Rubinstein-Taybi Syndrome	0.8%
678	Corneal Perforation	0.8%
679	Fragile X Syndrome	0.8%
680	Mucopolysaccharidosis II	0.5%

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