MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Macrostomia

(UMLS:C0024433)

Definition:: Greatly exaggerated width of the mouth, resulting from failure of union of the maxillary and mandibular processes, with extension of the oral orifice toward the ear. The defect may be unilateral or bilateral. (Dorland, 27th ed)
UMLS ID:: C0024433
MeSH ID:: D008265

Classification 1:

Name:

Stomatognathic Diseases
MeSH Tree Number(s):: C07.465.525.480|C07.650.525.480

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.850.525.480

Synonym(s)

Macrostomia

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Imipramine			OFFSIDES
2	Isotretinoin		3465061	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Microstomia	51.6%
2	Cleft Palate	34.9%
3	Maxillofacial Abnormalities	24.3%
4	Facial Hemiatrophy	22.3%
5	Melkersson-Rosenthal Syndrome	22.3%
6	Dental Enamel Hypoplasia	20.9%
7	Hypodontia	20.9%
8	Burning Mouth Syndrome	20.2%
9	Lip Diseases	20.2%
10	Microglossia	20.2%
11	Oral Submucous Fibrosis	20.2%
12	Periodontal Diseases	20.2%
13	Salivary Gland Diseases	20.2%
14	Stomatitis	20.2%
15	Tongue Diseases	20.2%
16	Oral Ulcer	20.2%
17	Bell Palsy	19.1%
18	Tooth Loss	18.8%
19	Salivary Gland Fistula	17.6%
20	Salivary Gland Neoplasms	17.6%
21	Tongue Neoplasms	17.6%
22	Tooth Diseases	17.4%
23	Jaw Abnormalities	17.2%
24	Parotid Neoplasms	16.7%
25	Facial Nerve Diseases	16.3%
26	Granulomatosis, Orofacial	16.3%
27	Oral candidiasis	16.1%
28	Mouth Neoplasms	16.1%
29	Oral Fistula	16.1%
30	Lichen Planus, Oral	15.9%
31	Gingival Recession	15.7%
32	Parotitis	15.7%
33	Gingival Atrophy	15.7%
34	Gingival Hemorrhage	15.3%
35	Jaw Diseases	14.4%
36	Pharyngeal Diseases	14.4%
37	Mobius Syndrome	14.4%
38	Retrognathia	13.8%
39	Facial paralysis	13.3%
40	Facial Paresis	13.3%
41	Cheilitis	13.2%
42	Drooling	13.2%
43	Gingival Diseases	13.2%
44	Glossitis	13.2%
45	Macroglossia	13.2%
46	Periodontitis	13.2%
47	Sialadenitis	13.2%
48	Sialometaplasia, Necrotizing	13.2%
49	Sialorrhea	13.2%
50	Aphthous Stomatitis	13.2%
51	Xerostomia	13.2%
52	Glossoptosis	13.2%
53	Hemifacial Spasm	13.2%
54	Peri-Implantitis	13.2%
55	Abnormalities, Drug-Induced	12.6%
56	Situs Inversus	12.6%
57	Prognathism	12.5%
58	Micrognathism	12.4%
59	Pierre Robin Syndrome	12.4%
60	Beckwith-Wiedemann Syndrome	11.6%
61	Wolf-Hirschhorn Syndrome	11.6%
62	Giant Cell Epulis	11.5%
63	Temporomandibular Joint Disorders	11.1%
64	Holoprosencephaly	10.9%
65	Facial Neuralgia	10.6%
66	Dental Fistula	10.5%
67	Oroantral Fistula	10.5%
68	Eye Abnormalities	10.5%
69	Cardiovascular Abnormalities	10.5%
70	Skin Abnormalities	10.2%
71	Lymphatic Abnormalities	10.2%
72	Congenital Microtia	10.2%
73	Radicular Cyst	10.1%
74	Bruxism	10.1%
75	Dental Leakage	10.1%
76	Hypercementosis	10.1%
77	Malocclusion	10.1%
78	Tooth Crowding	10.1%
79	Tooth Discoloration	10.1%
80	Tooth Demineralization	10.1%
81	Tooth Ankylosis	10.1%
82	Aicardi's syndrome	10.1%
83	Smith-Magenis syndrome	10%
84	Congenital diaphragmatic hernia	10%
85	Behcet Syndrome	9.9%
86	Cri-du-Chat Syndrome	9.9%
87	Down Syndrome	9.9%
88	Trisomy 21	9.9%
89	Gingivitis	9.8%
90	Glossitis, Benign Migratory	9.8%
91	Pericoronitis	9.8%
92	Aggressive Periodontitis	9.8%
93	Gingival Overgrowth	9.8%
94	Vesicular Stomatitis	9.1%
95	Rubinstein-Taybi Syndrome	8.9%
96	Urogenital Abnormalities	8.8%
97	Palatal Neoplasms	8.7%
98	Ectodermal Dysplasia	8.7%
99	Aplasia Cutis Congenita	8.7%
100	Mouth Diseases	8.7%
101	Prader-Willi Syndrome	8.6%
102	Tooth Injuries	8.4%
103	Anencephaly	8.2%
104	Gingival Hyperplasia	8.2%
105	Gingival Hypertrophy	8.2%
106	Maxillary Diseases	8.2%
107	Tooth Resorption	8.2%
108	Toothache	8%
109	Alveolar Bone Loss	7.9%
110	Trigeminal Nerve Disorder	7.8%
111	Genetic Diseases, Inborn	7.8%
112	CHARGE Syndrome	7.8%
113	Herpes Zoster Oticus	7.6%
114	Leukoplakia, Oral	7.5%
115	Herpes Labialis	7.5%
116	Prune Belly Syndrome	7.4%
117	Twins, Conjoined	7.4%
118	Waardenburg Syndrome	7.4%
119	Dural Arteriovenous Fistula	7.1%
120	Dextrocardia	7.1%
121	Kartagener Syndrome	6.9%
122	Pharyngitis	6.9%
123	Mouth Abnormalities	6.8%
124	Nail-Patella Syndrome	6.8%
125	Marfan Syndrome	6.7%
126	Xeroderma	6.7%
127	Nasopharyngitis	6.6%
128	Dental caries	6.6%
129	Dental Plaque	6.6%
130	Dental Pulp Calcification	6.6%
131	Pulpitis	6.6%
132	Tooth Erosion	6.6%
133	Facial Nerve Injuries	6.6%
134	Mumps	6.5%
135	Trigeminal Neuralgia	6.5%
136	Fetal Diseases	6.3%
137	Temporomandibular Joint Dysfunction Syndrome	6.2%
138	Abnormalities, Radiation-Induced	6.2%
139	Anophthalmos	6%
140	Anus, Imperforate	6%
141	Hydranencephaly	6%
142	Microphthalmos	6%
143	Neural Tube Defects	6%
144	Tethered Cord Syndrome	6%
145	Iniencephaly	6%
146	Craniorachischisis	6%
147	Limb Deformities, Congenital	6%
148	Exencephaly	6%
149	Septo-Optic Dysplasia	6%
150	Craniofacial Abnormalities	6%
151	Cortical Dysplasia	6%
152	Malformations of Cortical Development	6%
153	Anorectal Malformations	6%
154	Bloom Syndrome	6%
155	Nasopharyngeal Neoplasms	5.9%
156	Pharyngeal Neoplasms	5.8%
157	Toxic Epidermal Necrolysis	5.8%
158	Stevens-Johnson Syndrome	5.8%
159	Scimitar Syndrome	5.6%
160	Polycystic Kidney Diseases	5.6%
161	Williams Syndrome	5.6%
162	Cockayne Syndrome	5.5%
163	Ulcerative stomatitis	5.5%
164	Tooth Avulsion	5.4%
165	Dental Pulp Necrosis	5.3%
166	Alstrom Syndrome	5.2%
167	Retinal Dysplasia	5.1%
168	Blepharophimosis	5.1%
169	Laryngostenosis	5.1%
170	Aniridia	5.1%
171	Esophageal Atresia	5%
172	Intestinal Atresia	5%
173	Horseshoe Kidney	5%
174	Pectus excavatum	5%
175	Klippel-Feil Syndrome	5%
176	Gastroschisis	5%
177	Synostosis	5%
178	Epidermolysis Bullosa	5%
179	Acrodermatitis	5%
180	Lymphangiectasis, Intestinal	5%
181	Gianotti-Crosti Syndrome	5%
182	Cystic Fibrosis	4.9%
183	Basal Cell Nevus Syndrome	4.9%
184	Craniosynostosis	4.9%
185	Syndactyly	4.9%
186	Brachycephaly	4.9%
187	Microcephaly	4.9%
188	Macrocephaly	4.9%
189	Fragile X Syndrome	4.9%
190	Smith-Lemli-Opitz Syndrome	4.7%
191	Ichthyosis, X-Linked	4.6%
192	Primary Ciliary Dyskinesia	4.5%
193	Acrocephalosyndactylia	4.4%
194	Noonan Syndrome	4.4%
195	Tonsillitis	4.4%
196	Sleep Bruxism	4.4%
197	Macrostomia	4.4%
198	Lemierre Syndrome	4.4%
199	Arthrogryposis	4.4%
200	Choanal Atresia	4.4%
201	Tracheobronchomegaly	4.4%
202	Laryngocele	4.4%
203	Sicca Syndrome	4.4%
204	Sjogren's Syndrome	4.4%
205	Choledochal Cyst	4.3%
206	Hermaphroditism	4.3%
207	Disorders of Sex Development	4.3%
208	Cryptorchidism	4.3%
209	Hypospadias	4.3%
210	Central Nervous System Cysts	4.3%
211	Dandy-Walker Syndrome	4.3%
212	Meconium Aspiration Syndrome	4.3%
213	Turner Syndrome	4.2%
214	POEMS Syndrome	4.2%
215	Abdominal Cramps	4.2%
216	Amniotic Band Syndrome	4.2%
217	Asphyxia Neonatorum	4.2%
218	Infant, Premature, Diseases	4.2%
219	Infantile Colic	4.2%
220	Porencephaly	4.2%
221	Classical Lissencephalies and Subcortical Band Heterotopias	4.1%
222	Pseudoxanthoma Elasticum	4%
223	Amelia	3.9%
224	Arachnodactyly	3.9%
225	Ectopia Cordis	3.9%
226	Ectromelia	3.9%
227	Hemimelia	3.9%
228	Meningomyelocele	3.9%
229	Phocomelia	3.9%
230	Sirenomelia	3.9%
231	Spina Bifida	3.9%
232	Polydactyly	3.9%
233	Brachydactyly	3.9%
234	Plagiocephaly	3.9%
235	Lower Extremity Deformities, Congenital	3.9%
236	Upper Extremity Deformities, Congenital	3.9%
237	Single umbilical artery	3.9%
238	Nasopharyngeal carcinoma	3.9%
239	Laryngomalacia	3.8%
240	Pectus carinatum	3.8%
241	Retropharyngeal Abscess	3.8%
242	Hypopharyngeal Neoplasms	3.8%
243	Hypopharyngeal Cancer	3.8%
244	Bladder Exstrophy	3.7%
245	Epispadias	3.7%
246	Multicystic Dysplastic Kidney	3.7%
247	Polycystic Kidney, Autosomal Dominant	3.7%
248	Sjogren-Larsson Syndrome	3.7%
249	Xeroderma Pigmentosum	3.6%
250	Poland Syndrome	3.6%
251	Neoplastic Syndromes, Hereditary	3.5%
252	Kallmann Syndrome	3.5%
253	Klinefelter Syndrome	3.4%
254	Anemia, Neonatal	3.4%
255	Multiple Epiphyseal Dysplasia	3.4%
256	Osteochondrodysplasias	3.4%
257	Pelger-Huet Anomaly	3.4%
258	Persistent Fetal Circulation Syndrome	3.4%
259	Werner Syndrome	3.4%
260	Myasthenic Syndromes, Congenital	3.4%
261	Umbilical hernia	3.3%
262	Aortic coarctation	3.3%
263	Cor Triatriatum	3.3%
264	Coronary Vessel Anomalies	3.3%
265	Patent ductus arteriosus	3.3%
266	Ebstein Anomaly	3.3%
267	Heart Septal Defects	3.3%
268	Meningocele	3.3%
269	Tetralogy of Fallot	3.3%
270	Transposition of Great Vessels	3.3%
271	Hypoplastic Left Heart Syndrome	3.3%
272	May-Thurner Syndrome	3.3%
273	Encephalocele	3.3%
274	Craniofacial Dysostosis	3.3%
275	Zellweger Syndrome	3.3%
276	Wolff-Parkinson-White Syndrome	3.3%
277	Charcot-Marie-Tooth Disease	3.3%
278	Antley-Bixler Syndrome Phenotype	3.3%
279	Hyperkeratosis, Epidermolytic	3.1%
280	Tuberous Sclerosis	3%
281	Dermal Sinus	2.9%
282	Spina Bifida Cystica	2.9%
283	Spina Bifida Occulta	2.9%
284	Lissencephaly	2.9%
285	Polymicrogyria	2.9%
286	Pachygyria	2.9%
287	Schizencephaly	2.9%
288	Periventricular Nodular Heterotopia	2.9%
289	Dwarfism	2.9%
290	Neonatal Abstinence Syndrome	2.9%
291	Long QT Syndrome	2.8%
292	Platybasia	2.8%
293	Tricuspid Atresia	2.8%
294	Arrhythmogenic Right Ventricular Dysplasia	2.8%
295	Anemia, Sickle Cell	2.8%
296	Thalassemia	2.8%
297	Gonadal Dysgenesis	2.8%
298	Bronchomalacia	2.8%
299	Adrenogenital Syndrome	2.8%
300	Tracheomalacia	2.8%
301	Ovotesticular Disorders of Sex Development	2.8%
302	Muscular Dystrophy, Duchenne	2.8%
303	Fetal Growth Retardation	2.8%
304	Peritonsillar Abscess	2.8%
305	Tonsillar Neoplasms	2.8%
306	Muscular Dystrophy	2.8%
307	Osteogenesis Imperfecta	2.8%
308	Refsum Disease	2.8%
309	Fetal Hypoxia	2.8%
310	Congenital nystagmus	2.8%
311	Fetal Alcohol Spectrum Disorders	2.8%
312	Toxoplasmosis, Congenital	2.8%
313	Syphilis, Congenital	2.7%
314	Albinism	2.6%
315	Hyperandrogenism	2.6%
316	Familial Mediterranean Fever	2.5%
317	Aortopulmonary Septal Defect	2.4%
318	Double Outlet Right Ventricle	2.4%
319	Endocardial Cushion Defects	2.4%
320	Myocardial bridging	2.4%
321	Aorticopulmonary Septal Defect	2.4%
322	Autoimmune Lymphoproliferative Syndrome	2.4%
323	Congenital Hyperinsulinism	2.4%
324	Chorioamnionitis	2.4%
325	Angioedemas, Hereditary	2.4%
326	Wiskott-Aldrich Syndrome	2.2%
327	Rett Syndrome	2.2%
328	Mandibulofacial Dysostosis	2.1%
329	Romano-Ward Syndrome	2.1%
330	Mucopolysaccharidosis II	2%
331	Truncus Arteriosus, Persistent	2%
332	Goldenhar Syndrome	2%
333	Paralysis, Obstetric	2%
334	Retinopathy of Prematurity	2%
335	Menkes Kinky Hair Syndrome	2%
336	Amino Acid Metabolism, Inborn Errors	2%
337	Carbohydrate Metabolism, Inborn Errors	2%
338	Metal Metabolism, Inborn Errors	2%
339	Progeria	2%
340	Lysosomal Storage Diseases	2%
341	Cytochrome-c Oxidase Deficiency	2%
342	Peroxisomal Disorders	2%
343	Bronchopulmonary Dysplasia	2%
344	Myotonic Dystrophy	2%
345	Sickle Cell Trait	1.9%
346	Neuronal Ceroid-Lipofuscinoses	1.8%
347	Ophthalmia Neonatorum	1.8%
348	Talipes	1.8%
349	Respiratory Distress Syndrome, Newborn	1.7%
350	Cutis Laxa	1.7%
351	Ataxia Telangiectasia	1.7%
352	Retinitis Pigmentosa	1.7%
353	Pigmentary retinopathy	1.7%
354	Porokeratosis	1.7%
355	Keratoderma, Palmoplantar	1.7%
356	Chronic granulomatous disease	1.6%
357	Hepatolenticular Degeneration	1.6%
358	Welander Distal Myopathy	1.6%
359	Arteriovenous fistula	1.6%
360	Amyloid Neuropathies, Familial	1.6%
361	Adrenoleukodystrophy	1.6%
362	Congenital clubfoot	1.6%
363	Vertical Talus	1.6%
364	Hydrops Fetalis	1.5%
365	Acute Chest Syndrome	1.5%
366	Duane Retraction Syndrome	1.4%
367	Galactosemias	1.4%
368	Urea Cycle Disorders, Inborn	1.4%
369	Tyrosinemias	1.4%
370	Fabry Disease	1.4%
371	Porphyrias, Hepatic	1.4%
372	Peutz-Jeghers Syndrome	1.4%
373	Myotonia Congenita	1.4%
374	Thrombasthenia	1.4%
375	Antithrombin III Deficiency	1.4%
376	Protein C Deficiency	1.4%
377	Brain Diseases, Metabolic, Inborn	1.4%
378	Afibrinogenemia	1.4%
379	Dystonia Musculorum Deformans	1.4%
380	Factor VII Deficiency	1.4%
381	Factor X Deficiency	1.4%
382	Factor XII Deficiency	1.4%
383	Hemophilia A	1.4%
384	Leukomalacia, Periventricular	1.4%
385	Activated Protein C Resistance	1.4%
386	Factor II deficiency	1.4%
387	Factor VIII Deficiency	1.4%
388	Factor V deficiency	1.4%
389	Factor XI Deficiency	1.4%
390	Hypoprothrombinemias	1.4%
391	Fanconi Anemia	1.4%
392	Nesidioblastosis	1.4%
393	Lafora Disease	1.4%
394	Unverricht-Lundborg Syndrome	1.4%
395	Anemia, Diamond-Blackfan	1.4%
396	Denys-Drash Syndrome	1.4%
397	Canavan Disease	1.3%
398	Alexander Disease	1.3%
399	Glycogen storage disease type II	1.3%
400	Alkaptonuria	1.3%
401	Glycogen Storage Disease	1.3%
402	Hypophosphatasia	1.3%
403	Propionic acidemia	1.3%
404	Dihydropyrimidine Dehydrogenase Deficiency	1.3%
405	Cystinosis	1.3%
406	Optic Atrophy, Hereditary, Leber	1.3%
407	Hyperphosphaturia	1.3%
408	Multiple Endocrine Neoplasia	1.3%
409	Congenital Hypothyroidism	1.3%
410	Dermatitis, Atopic	1.2%
411	Mucopolysaccharidosis III	1.2%
412	Homocystinuria	1.1%
413	Leigh Disease	1.1%
414	Kernicterus	1.1%
415	Hyaline Membrane Disease	1.1%
416	Hypolipoproteinemias	1.1%
417	Papillon-Lefevre Disease	1.1%
418	Hyperlipidemia, Familial Combined	1.1%
419	Hyperlipoproteinemia Type III	1.1%
420	Gaucher Disease	1%
421	Huntington Disease	1%
422	Glycogen Storage Disease Type I	1%
423	Glycogen Storage Disease Type V	1%
424	Carbamoyl-Phosphate Synthase I Deficiency Disease	1%
425	Familial Periodic Paralysis	0.9%
426	Lactose Intolerance	0.9%
427	Variegate Porphyria	0.9%
428	Acute intermittent porphyria	0.9%
429	Porphyria Cutanea Tarda	0.9%
430	Hyperhomocysteinemia	0.9%
431	Renal Aminoacidurias	0.9%
432	Fanconi Syndrome	0.9%
433	Pseudohypoaldosteronism	0.9%
434	Liddle Syndrome	0.9%
435	Hyperlipoproteinemia Type IV	0.9%
436	Hyperlipoproteinemia Type V	0.9%
437	Nephroblastoma	0.9%
438	Tay-Sachs Disease	0.8%
439	Gout	0.8%
440	Niemann-Pick Disease, Type C	0.8%
441	Multiple Endocrine Neoplasia Type 1	0.8%
442	Pseudohypoparathyroidism	0.8%
443	Friedreich Ataxia	0.8%
444	Adenomatous Polyposis Coli	0.8%
445	Renal tubular acidosis	0.8%
446	Hypoalphalipoproteinemias	0.8%
447	Hypokalemic periodic paralysis	0.7%
448	Cystinuria	0.7%
449	Glycosuria, Renal	0.6%
450	Familial Hypophosphatemic Rickets	0.6%
451	Arthritis, Gouty	0.6%
452	MELAS Syndrome	0.5%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234