MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

HIV Wasting Syndrome

(UMLS:C0343755)

Definition:: Involuntary weight loss of greater than 10 percent associated with intermittent or constant fever and chronic diarrhea or fatigue for more than 30 days in the absence of a defined cause other than HIV infection. A constant feature is major muscle wasting with scattered myofiber degeneration. A variety of etiologies, which vary among patients, contributes to this syndrome. (From Harrison's Principles of Internal Medicine, 13th ed, p1611).
UMLS ID:: C0343755
MeSH ID:: D019247

Classification 1:

Name:

Virus Diseases
MeSH Tree Number(s):: C02.782.815.616.400.520|C02.800.801.400.520

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.915.520|C18.654.940.520

Classification 3:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.673.480.520

Synonym(s)

HIV Wasting Syndrome

AIDS cachexia

AIDS wasting syndrome

AIDS with cachexia

Cachexia associated with AIDS

Cachexia associated with acquired immunodeficiency syndrome

HIV - Human immunodeficiency virus infection wasting syndrome

HIV WASTING SYNDROME

HIV disease resulting in wasting syndrome

10.

HIV disease; failure to thrive

11.

HIV disease; resulting in, failure to thrive

12.

HIV disease; resulting in, wasting syndrome

13.

HIV syndrome wasting

14.

HIV wasting disease

15.

HIV wasting syndrome

16.

Human immunodeficiency virus infection wasting syndrome

17.

Slim disease

18.

disease (or disorder); slim disease (HIV)

19.

disease; slim

20.

slim disease

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Lopinavir	FAERS: 2		US FAERS
2	Atazanavir Sulfate	FAERS: 1		OFFSIDES US FAERS
3	Atovaquone			OFFSIDES
4	Clarithromycin			OFFSIDES
5	Dapsone			OFFSIDES
6	Darunavir			OFFSIDES
7	Didanosine			OFFSIDES
8	Ethambutol			OFFSIDES
9	Foscarnet			OFFSIDES
10	Galactose			OFFSIDES
11	Ganciclovir			OFFSIDES
12	Hydrocortisone			OFFSIDES
13	Indinavir			OFFSIDES
14	Lamivudine			OFFSIDES
15	Nelfinavir			OFFSIDES
16	Oxandrolone		17961146	CTD
17	Pentamidine			OFFSIDES
18	Prednisone		9268244	CTD
19	Rifabutin			OFFSIDES
20	Ritonavir			OFFSIDES
21	Roxithromycin			OFFSIDES
22	Stavudine			OFFSIDES
23	Tenofovir			OFFSIDES
24	Tenofovir			OFFSIDES
25	Testosterone		17961146	CTD
26	Zalcitabine			OFFSIDES
27	Zidovudine			OFFSIDES
28	abacavir			OFFSIDES
29	amprenavir			OFFSIDES
30	efavirenz			OFFSIDES
31	testosterone enanthate		17440010	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	HIV Seropositivity	37.6%
2	Acquired Immunodeficiency Syndrome	37.2%
3	AIDS related complex	37.2%
4	HIV-Associated Lipodystrophy Syndrome	34.3%
5	AIDS Dementia Complex	30.1%
6	AIDS-Associated Nephropathy	30.1%
7	AIDS-Related Opportunistic Infections	23.3%
8	Hypercalcemia	15.1%
9	Hypocalcemia	15.1%
10	Milk-Alkali Syndrome	15.1%
11	Rickets	14.9%
12	Pseudohypoparathyroidism	14.4%
13	Simian Acquired Immunodeficiency Syndrome	14.1%
14	Leigh Disease	13.5%
15	Hyperhomocysteinemia	13.4%
16	Acid-Base Imbalance	13.3%
17	Calcium Metabolism Disorders	13.3%
18	Child Nutrition Disorders	13.3%
19	Iron Metabolism Disorders	13.3%
20	Hypervitaminosis A	13.3%
21	Infant Nutrition Disorders	13.3%
22	Phosphorus Metabolism Disorders	13.3%
23	Water-Electrolyte Imbalance	13.3%
24	Lipid Metabolism Disorders	13.3%
25	Malnutrition	13.3%
26	Mitochondrial Diseases	13.3%
27	Glucose Metabolism Disorders	13.3%
28	Lipodystrophy	13.2%
29	Familial Hypophosphatemic Rickets	12.8%
30	Murine Acquired Immunodeficiency Syndrome	12.6%
31	Condylomata Acuminata	12.5%
32	Carbamoyl-Phosphate Synthase I Deficiency Disease	12.4%
33	Rift Valley Fever	12.1%
34	Osteomalacia	11.7%
35	Brain Diseases, Metabolic, Inborn	11.7%
36	Hepatitis E	11.7%
37	Osteopenia	11.5%
38	HTLV-I Infections	11.5%
39	Brain Diseases, Metabolic	11.4%
40	Dengue Fever	11%
41	Yellow Fever	11%
42	Hemorrhagic Fever, Crimean	10.9%
43	Hyperlipoproteinemia Type IV	10.8%
44	Hyperlipoproteinemia Type V	10.8%
45	Smith-Lemli-Opitz Syndrome	10.7%
46	Galactosemias	10.6%
47	Urea Cycle Disorders, Inborn	10.6%
48	Tyrosinemias	10.6%
49	Gaucher Disease	10.5%
50	Orthomyxoviridae Infections	10.2%
51	Picornaviridae Infections	10.2%
52	Reoviridae Infections	10.2%
53	Lactose Intolerance	10.2%
54	Genital Herpes	9.9%
55	Arbovirus Infections	9.9%
56	Glycogen storage disease type II	9.9%
57	Hemorrhagic Fever, American	9.9%
58	Lassa Fever	9.9%
59	Hypolipoproteinemias	9.8%
60	Hyperphosphaturia	9.7%
61	Phlebotomus Fever	9.5%
62	Ataxia Telangiectasia	9.4%
63	Tay-Sachs Disease	9.4%
64	Homocystinuria	9.2%
65	Mitochondrial Encephalomyopathies	9.2%
66	Niemann-Pick Disease, Type C	9.1%
67	Warts	9.1%
68	Diabetic Ketoacidosis	9%
69	Hyperlipidemia, Familial Combined	8.9%
70	Congenital Hyperinsulinism	8.9%
71	Renal Osteodystrophy	8.8%
72	Renal rickets	8.8%
73	Acidosis	8.8%
74	Alkalosis	8.8%
75	Amyloidosis	8.8%
76	Calcinosis	8.8%
77	Deficiency Diseases	8.8%
78	Hyperglycemia	8.8%
79	Hyperinsulinism	8.8%
80	Hyperkalemia	8.8%
81	Hypernatremia	8.8%
82	Hypoglycemia	8.8%
83	Hypokalemia	8.8%
84	Hyponatremia	8.8%
85	Starvation	8.8%
86	Xanthomatosis	8.8%
87	Hypophosphatemia	8.8%
88	Metabolic acidosis	8.8%
89	Dyslipidemias	8.8%
90	Iron Overload	8.8%
91	Xanthoma	8.8%
92	Refeeding Syndrome	8.8%
93	Amyloid Neuropathies, Familial	8.7%
94	Fabry Disease	8.7%
95	Adrenoleukodystrophy	8.6%
96	Hyperlipoproteinemia Type III	8.5%
97	Lymphopenia	8.5%
98	Hepatitis, Viral, Human	8.5%
99	Viremia	8.4%
100	Hepatitis C	8.3%
101	Hypoalphalipoproteinemias	8.1%
102	Wernicke Encephalopathy	8%
103	Hemorrhagic Fever with Renal Syndrome	8%
104	West Nile Fever	7.9%
105	Zellweger Syndrome	7.9%
106	MELAS Syndrome	7.8%
107	Renal tubular acidosis	7.8%
108	Menkes Kinky Hair Syndrome	7.8%
109	Diabetes Mellitus	7.7%
110	Subacute Sclerosing Panencephalitis	7.7%
111	Opportunistic Infections	7.7%
112	Dehydration	7.6%
113	Lipomatosis	7.6%
114	Water Intoxication	7.6%
115	Werner Syndrome	7.6%
116	Zika Virus Infection	7.6%
117	Achlorhydria	7.5%
118	Amino Acid Metabolism, Inborn Errors	7.5%
119	Bloom Syndrome	7.5%
120	Carbohydrate Metabolism, Inborn Errors	7.5%
121	Metal Metabolism, Inborn Errors	7.5%
122	Osteoporosis	7.5%
123	Progeria	7.5%
124	Lysosomal Storage Diseases	7.5%
125	Bone Demineralization, Pathologic	7.5%
126	Cytochrome-c Oxidase Deficiency	7.5%
127	Peroxisomal Disorders	7.5%
128	Post-Traumatic Osteoporosis	7.5%
129	Latent Autoimmune Diabetes in Adults	7.5%
130	Celiac Disease	7.5%
131	Sprue, Tropical	7.5%
132	Steatorrhea	7.5%
133	Sprue	7.5%
134	Agammaglobulinemia	7.5%
135	Hepatitis, Viral, Animal	7.4%
136	Pneumonia, Viral	7.4%
137	Hepatolenticular Degeneration	7.4%
138	Primary amyloidosis	7.3%
139	Refsum Disease	7.3%
140	Nesidioblastosis	7.3%
141	Neuronal Ceroid-Lipofuscinoses	7.2%
142	Epstein-Barr Virus Infections	7.1%
143	Leukoencephalopathy, Progressive Multifocal	7.1%
144	Chronic Fatigue Syndrome	6.7%
145	Mitochondrial Myopathies	6.7%
146	Kernicterus	6.6%
147	Myelinolysis, Central Pontine	6.6%
148	Hepatitis A	6.6%
149	Glycosuria	6.6%
150	Reye Syndrome	6.6%
151	Hepatic Encephalopathy	6.5%
152	Acidosis, Lactic	6.5%
153	Calciphylaxis	6.5%
154	Hemosiderosis	6.5%
155	Ketosis	6.5%
156	Kwashiorkor	6.5%
157	Magnesium Deficiency	6.5%
158	Potassium Deficiency	6.5%
159	Protein Deficiency	6.5%
160	Ketonuria	6.5%
161	Ketoacidosis	6.5%
162	Ketonemia	6.5%
163	Vascular calcification	6.5%
164	Avitaminosis	6.5%
165	Glycosuria, Renal	6.5%
166	Mucopolysaccharidosis III	6.5%
167	Hepatitis B	6.2%
168	Molluscum Contagiosum	6.2%
169	Porphyrias, Hepatic	5.9%
170	Necrobiosis Lipoidica Diabeticorum	5.9%
171	Fanconi Anemia	5.8%
172	Obesity	5.8%
173	Wasting Syndrome	5.8%
174	Enterovirus Infections	5.8%
175	Flavivirus Infections	5.8%
176	Paramyxoviridae Infections	5.8%
177	Cardiovirus Infections	5.8%
178	Rhabdoviridae Infections	5.8%
179	Autoimmune Diseases	5.7%
180	Hypersensitivity	5.7%
181	Immunoproliferative Disorders	5.7%
182	Metabolic Diseases	5.7%
183	Immune reconstitution syndrome	5.7%
184	Immune Reconstitution Inflammatory Syndrome	5.7%
185	Nutrition Disorders	5.7%
186	Pseudorabies	5.6%
187	Acidosis, Respiratory	5.6%
188	Adiposis Dolorosa	5.6%
189	Alkalosis, Respiratory	5.6%
190	Job Syndrome	5.6%
191	Kearns-Sayre syndrome	5.6%
192	Alkaptonuria	5.6%
193	Glycogen Storage Disease	5.6%
194	Hypophosphatasia	5.6%
195	Insulin Resistance	5.6%
196	Osteoporosis, Postmenopausal	5.6%
197	Propionic acidemia	5.6%
198	Dihydropyrimidine Dehydrogenase Deficiency	5.6%
199	Cystinosis	5.6%
200	Erythema Infectiosum	5.5%
201	Ascorbic Acid Deficiency	5.4%
202	Hypercholesterolemia	5.4%
203	Hyperlipoproteinemias	5.4%
204	Hypertriglyceridemia	5.4%
205	Vitamin A Deficiency	5.4%
206	Vitamin D Deficiency	5.4%
207	Vitamin E Deficiency	5.4%
208	Marasmus	5.4%
209	Epidermodysplasia Verruciformis	5.3%
210	Herpesviridae Infections	5.3%
211	Polyomavirus Infections	5.3%
212	Friedreich Ataxia	5.2%
213	Sjogren-Larsson Syndrome	5.1%
214	Foot-and-Mouth Disease	5.1%
215	Gestational Diabetes	5%
216	Canavan Disease	5%
217	Alexander Disease	5%
218	Common Cold	5%
219	Influenza	5%
220	Catarrh	5%
221	Diabetes Mellitus, Experimental	5%
222	Mucopolysaccharidosis II	5%
223	Herpes Zoster Ophthalmicus	5%
224	Chronic granulomatous disease	4.9%
225	Nephrocalcinosis	4.9%
226	Tetany	4.9%
227	Transfusion Reaction	4.9%
228	Hypotensive Transfusion Reaction	4.9%
229	Folic Acid Deficiency	4.9%
230	Pellagra	4.9%
231	Thiamine Deficiency	4.9%
232	Vitamin B 12 Deficiency	4.9%
233	Vitamin B 6 Deficiency	4.9%
234	Pyridoxine Deficiency	4.9%
235	Cerebral Amyloid Angiopathy	4.9%
236	Obesity, Abdominal	4.9%
237	Cockayne Syndrome	4.8%
238	Keratitis, Herpetic	4.8%
239	Cytomegalovirus Retinitis	4.8%
240	Exanthema Subitum	4.8%
241	Glycogen Storage Disease Type I	4.6%
242	Glycogen Storage Disease Type V	4.6%
243	Beriberi	4.6%
244	Familial Periodic Paralysis	4.4%
245	Variegate Porphyria	4.4%
246	Acute intermittent porphyria	4.4%
247	Porphyria Cutanea Tarda	4.4%
248	Hepatitis C, Chronic	4.3%
249	Optic Atrophy, Hereditary, Leber	4.3%
250	Renal Aminoacidurias	4.3%
251	Fanconi Syndrome	4.3%
252	Pseudohypoaldosteronism	4.3%
253	Liddle Syndrome	4.3%
254	Pediatric Obesity	4.3%
255	Herpangina	4.2%
256	Glomerulonephritis, Membranoproliferative	4.2%
257	Vitamin K Deficiency	4.1%
258	Xeroderma Pigmentosum	4.1%
259	Superinfection	4%
260	Gout	4%
261	Amyotrophic Lateral Sclerosis	4%
262	Prader-Willi Syndrome	3.9%
263	Anemia, Pernicious	3.9%
264	Antley-Bixler Syndrome Phenotype	3.9%
265	Autoimmune Lymphoproliferative Syndrome	3.7%
266	Eczema Herpeticum	3.7%
267	Scurvy	3.7%
268	Burkitt Lymphoma	3.6%
269	Hypokalemic periodic paralysis	3.6%
270	HIV Wasting Syndrome	3.6%
271	Frontotemporal dementia	3.6%
272	Cystinuria	3.6%
273	Wiskott-Aldrich Syndrome	3.6%
274	CREST Syndrome	3.6%
275	Coxsackievirus Infections	3.5%
276	Rubella	3.5%
277	Coronavirus Infections	3.5%
278	Nipah Virus Infection	3.5%
279	Hydrophobia	3.5%
280	Immune Complex Diseases	3.3%
281	Antiphospholipid Syndrome	3.3%
282	Latex allergy	3.3%
283	Thrombocytopenic purpura	3.3%
284	Albinism	3.3%
285	Autoimmune thrombocytopenia	3.3%
286	Immune thrombocytopenic purpura	3.3%
287	Herpes Labialis	3.3%
288	Hepatitis B, Chronic	3.3%
289	Arthritis, Gouty	3.3%
290	Sexually Transmitted Diseases	3.2%
291	Porcine Reproductive and Respiratory Syndrome	3.1%
292	Cytomegalovirus Infections	3%
293	Smallpox	3%
294	Varicella Zoster Virus Infection	3%
295	Environmental Illness	2.9%
296	Monoclonal Gammopathy of Undetermined Significance	2.9%
297	Lupus Erythematosus, Systemic	2.9%
298	Lymphoproliferative Disorders	2.9%
299	Overlap syndrome	2.9%
300	Addison Disease	2.9%
301	Paraproteinemias	2.9%
302	Pemphigus	2.9%
303	Autoimmune thyroiditis	2.9%
304	Primary Adrenal Insufficiency	2.9%
305	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	2.8%
306	Autoimmune hepatitis	2.8%
307	Subacute Combined Degeneration	2.8%
308	Ichthyosis, X-Linked	2.8%
309	Retroviridae Infections	2.8%
310	Infectious Mononucleosis	2.7%
311	Vesicular Stomatitis	2.7%
312	Asthma, Aspirin-Induced	2.6%
313	Serum Sickness	2.5%
314	Hypergammaglobulinemia	2.5%
315	Dermatitis Herpetiformis	2.5%
316	Kounis Syndrome	2.5%
317	Transfusion-Related Acute Lung Injury	2.5%
318	Measles	2.4%
319	Pleurodynia, Epidemic	2.4%
320	Respiratory Syncytial Virus Infections	2.4%
321	Multiple Myeloma	2.4%
322	Poliomyelitis	2.4%
323	Rheumatoid Arthritis	2.2%
324	Juvenile arthritis	2.2%
325	Graves Disease	2.2%
326	anaphylaxis	2.2%
327	Food Allergy	2.2%
328	Anti-Glomerular Basement Membrane Disease	2.2%
329	Anaphylactic shock	2.2%
330	Gastroenteritis, Transmissible, of Swine	2.1%
331	Severe Acute Respiratory Syndrome	2.1%
332	Mumps	2.1%
333	Bell Palsy	2%
334	Sezary Syndrome	2%
335	Respiratory Hypersensitivity	1.9%
336	Chickenpox	1.9%
337	Sick Building Syndrome	1.9%
338	Multiple Chemical Sensitivity	1.9%
339	Plasmacytoma	1.9%
340	Tumor Lysis Syndrome	1.9%
341	Urticaria	1.9%
342	Vasculitis, Leukocytoclastic, Cutaneous	1.9%
343	HIV Infections	1.9%
344	Myasthenia Gravis, Autoimmune, Experimental	1.8%
345	Lymphoma	1.7%
346	Myasthenia Gravis	1.7%
347	Uveomeningoencephalitic Syndrome	1.7%
348	Mastocytosis	1.7%
349	Drug Eruptions	1.6%
350	Hydrops Fetalis	1.6%
351	Heavy Chain Disease	1.6%
352	Granulomatosis with polyangiitis	1.6%
353	Dermatitis, Allergic Contact	1.6%
354	Milk Allergy	1.6%
355	Schnitzler Syndrome	1.6%
356	Wheat Hypersensitivity	1.6%
357	Stiff-Person Syndrome	1.5%
358	Polyradiculoneuropathy	1.5%
359	Polyradiculoneuritis	1.5%
360	Cryoglobulinemia	1.5%
361	Felty Syndrome	1.5%
362	POEMS Syndrome	1.5%
363	Lupus Nephritis	1.5%
364	Lupus Vasculitis, Central Nervous System	1.4%
365	Mastocytosis, Systemic	1.4%
366	Neuromyelitis Optica	1.4%
367	Leukoencephalitis, Acute Hemorrhagic	1.4%
368	Vasculitis, Central Nervous System	1.3%
369	Dermatitis, Atopic	1.3%
370	Rheumatoid Vasculitis	1.3%
371	Angioedema	1.2%
372	Multiple Sclerosis	1.2%
373	Hodgkin Disease	1.2%
374	Leukemia, Plasma Cell	1.2%
375	Lymphoma, Non-Hodgkin	1.2%
376	Leukemia, T-Cell	1.2%
377	Acute Generalized Exanthematous Pustulosis	1.2%
378	Leukemia, B-Cell	1.2%
379	Lambert-Eaton Myasthenic Syndrome	1.2%
380	Waldenstrom Macroglobulinemia	1.2%
381	Sicca Syndrome	1.2%
382	Sjogren's Syndrome	1.2%
383	Asthma	1.1%
384	Composite Lymphoma	1.1%
385	Encephalomyelitis, Acute Disseminated	1.1%
386	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	1.1%
387	Erythema Nodosum	1.1%
388	Neuritis, Autoimmune, Experimental	1.1%
389	Dermatitis, Photoallergic	1.1%
390	Lymphangioleiomyomatosis	1.1%
391	Asthma, Exercise-Induced	1%
392	Status Asthmaticus	1%
393	Multiple Sclerosis, Chronic Progressive	1%
394	Multiple Sclerosis, Relapsing-Remitting	1%
395	Lymphoma, Follicular	1%
396	T-Cell Lymphoma	1%
397	Mantle cell lymphoma	1%
398	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1%
399	Leukemia, Large Granular Lymphocytic	1%
400	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1%
401	Aspergillosis, Allergic Bronchopulmonary	1%
402	Guillain-Barre Syndrome	1%
403	Asthma, Occupational	0.9%
404	Herpes Zoster Oticus	0.9%
405	Farmer's Lung	0.9%
406	Angioedemas, Hereditary	0.9%
407	Hereditary Angioedema Type III	0.9%
408	Hereditary Angioedema Types I and II	0.9%
409	Lymphoma, T-Cell, Cutaneous	0.9%
410	Lymphoma, AIDS-Related	0.9%
411	Enteropathy-Associated T-Cell Lymphoma	0.9%
412	Primary Effusion Lymphoma	0.9%
413	Hay fever	0.9%
414	Rhinitis, Allergic, Perennial	0.9%
415	Toxic Epidermal Necrolysis	0.9%
416	Stevens-Johnson Syndrome	0.9%
417	Mycosis Fungoides	0.9%
418	Lymphomatoid Papulosis	0.9%
419	Plasmablastic lymphoma	0.9%
420	Lymphomatoid Granulomatosis	0.8%
421	Giant Cell Arteritis	0.8%
422	Temporal Arteritis	0.8%
423	Myelitis, Transverse	0.8%
424	Miller Fisher Syndrome	0.6%

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