MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Kleine-Levin Syndrome

(UMLS:C0206085)

Definition:: A rare condition characterized by recurrent hypersomnias associated with hyperphagia, occurring primarily in males in the second to third decade of life. Clinical features include mental confusion, excessive sleep requirements (approximately 18 hours per day), restlessness, and in some cases hallucinations. Episodes have a duration of days to weeks, and may recur several times per year. This condition may resolve spontaneously over several years. (From Adams, et al., Principles of Neurology, 6th ed, p569)
UMLS ID:: C0206085
MeSH ID:: D017593

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.886.425.800.200.500

Classification 2:

Name:

Mental Disorders
MeSH Tree Number(s):: F03.870.400.800.200.500

Synonym(s)

Kleine-Levin Syndrome

Hypersomnia-bulimia syndrome

KLEINE-LEVIN HIBERNATION SYNDROME

Kleine Levin Syndrome

Kleine Levin syndrome

Kleine-Levin

Kleine-Levin syndrome

hypersomnia-bulimia; syndrome

kleine levin syndrome

10.

kleine-levin syndrome

11.

syndrome; hypersomnia-bulimia

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Isotretinoin		20163374	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Narcolepsy	49.2%
2	Cataplexy	36.8%
3	Sleep Initiation and Maintenance Disorders	36%
4	Transient Insomnia	36%
5	Chronic Insomnia	36%
6	Restless Legs Syndrome	32.8%
7	Nocturnal Myoclonus Syndrome	24.2%
8	Parasomnia	22.7%
9	Sleep Disorders, Circadian Rhythm	22.6%
10	Sleep Deprivation	19%
11	Sleep Apnea Syndromes	18.1%
12	Sleep Talking	12.2%
13	Jet Lag Syndrome	12%
14	Sleep Apnea, Obstructive	12%
15	Sleep Apnea, Central	12%
16	Neurotic Disorders	11.3%
17	Sleep Bruxism	9.8%
18	Anxiety Disorders	9.8%
19	Avoidant Personality Disorder	9.8%
20	Cranial nerve diseases	9.8%
21	Demyelinating Diseases	9.8%
22	Demyelination	9.8%
23	Dissociative disorder	9.8%
24	Frigidity	9.8%
25	Hypoactive Sexual Desire Disorder	9.8%
26	Disruptive, Impulse Control, and Conduct Disorders	9.8%
27	Intermittent Explosive Disorder	9.8%
28	Kleptomania	9.8%
29	Narcissistic Personality Disorder	9.8%
30	Neuromuscular Diseases	9.8%
31	Personality Disorders	9.8%
32	Sexual Aversion Disorder	9.8%
33	Somatoform Disorder	9.8%
34	Dissociation	9.8%
35	Motor Disorders	9.8%
36	Chronobiology Disorders	9.8%
37	Mood Disorders	9.8%
38	Schizophrenia Spectrum and Other Psychotic Disorders	9.8%
39	Neurodevelopmental Disorders	9.8%
40	Neurocognitive Disorders	9.8%
41	Feeding and Eating Disorders	9.8%
42	Drug abuse	7.7%
43	Substance Dependence	7.7%
44	Substance-Related Disorders	7.7%
45	Trauma, Nervous System	7.7%
46	Drug Dependence	7.7%
47	Separation Anxiety Disorder	7.6%
48	Motor Neuron Disease	7.6%
49	Nervous System Neoplasms	7.4%
50	Neurologic Manifestations	7.4%
51	Neurotoxicity Syndromes	7.4%
52	Night Terrors	7.2%
53	Somnambulism	7.2%
54	Sleep Paralysis	7.2%
55	REM Sleep Behavior Disorder	7.2%
56	Stiff-Person Syndrome	6.4%
57	Ocular Motility Disorders	6.3%
58	Cyclophoria	6.3%
59	Multiple System Atrophy	6%
60	Polyradiculoneuropathy	5.8%
61	Polyradiculoneuritis	5.8%
62	Encephalomyelitis	5.8%
63	Prion Diseases	5.8%
64	Autonomic Dysreflexia	5.8%
65	Complex Regional Pain Syndromes	5.8%
66	Dementia	5.8%
67	Subacute Combined Degeneration	5.5%
68	Lewy Body Disease	5.1%
69	Adjustment Disorders	4.9%
70	Affective Disorders, Psychotic	4.9%
71	Agoraphobia	4.9%
72	Anorexia Nervosa	4.9%
73	Antisocial Personality Disorder	4.9%
74	Bipolar Disorder	4.9%
75	Body Dysmorphic Disorders	4.9%
76	Borderline Personality Disorder	4.9%
77	Brain Diseases	4.9%
78	Capgras Syndrome	4.9%
79	Child Behavior Disorders	4.9%
80	Developmental Disabilities	4.9%
81	Child Development Disorders, Pervasive	4.9%
82	Claustrophobia	4.9%
83	Cognition Disorders	4.9%
84	Conversion disorder	4.9%
85	Cyclothymic Disorder	4.9%
86	Dependent Personality Disorder	4.9%
87	Depressive disorder	4.9%
88	Developmental Coordination Disorder	4.9%
89	Dysautonomia	4.9%
90	Exhibitionism	4.9%
91	Factitious Disorders	4.9%
92	Firesetting Behavior	4.9%
93	Head Banging	4.9%
94	Histrionic Personality Disorder	4.9%
95	Hypochondriasis	4.9%
96	Masochism	4.9%
97	Melancholia	4.9%
98	Meningitis	4.9%
99	Motor Skills Disorders	4.9%
100	Movement Disorders	4.9%
101	Dissociative Identity Disorder	4.9%
102	Neurasthenia	4.9%
103	Obsessive-Compulsive Disorder	4.9%
104	Oppositional Defiant Disorder	4.9%
105	Pachymeningitis	4.9%
106	Panic Disorder	4.9%
107	Paranoid Personality Disorder	4.9%
108	Pedophilia	4.9%
109	Pseudodementia	4.9%
110	Psychotic Disorders	4.9%
111	Sadism	4.9%
112	Schizoaffective Disorder	4.9%
113	Schizoid Personality Disorder	4.9%
114	Schizophrenia	4.9%
115	Schizophrenia, Childhood	4.9%
116	Schizotypal Personality Disorder	4.9%
117	Spinal Cord Diseases	4.9%
118	Stereotypic Movement Disorder	4.9%
119	Transvestism	4.9%
120	Trichotillomania	4.9%
121	Voyeurism	4.9%
122	Vagus Nerve Disorder	4.9%
123	Glossopharyngeal Neuralgia	4.9%
124	Attention Deficit and Disruptive Behavior Disorders	4.9%
125	Hyperkinetic Heart Syndrome	4.9%
126	Abducens Nerve Diseases	4.9%
127	Reactive Attachment Disorder	4.9%
128	Sexual and Gender Disorders	4.9%
129	Gender Dysphoria	4.9%
130	Heavy Metal Poisoning, Nervous System	4.9%
131	Neuromuscular Junction Diseases	4.9%
132	Tauopathies	4.9%
133	Paranoia	4.9%
134	Compulsive Personality Disorder	4.9%
135	Bulimia Nervosa	4.9%
136	Trochlear Nerve Diseases	4.9%
137	Peripheral Nervous System Diseases	4.9%
138	Marchiafava-Bignami Disease	4.9%
139	Spinal Muscular Atrophy	4.9%
140	Progressive Muscular Atrophy	4.9%
141	Spinal Cord Injuries	4.8%
142	Peripheral Nerve Injuries	4.7%
143	Amyotrophic Lateral Sclerosis	4.7%
144	Ophthalmoplegic Migraine	4.6%
145	Myasthenia Gravis	4.6%
146	Asterixis	4.6%
147	Ballismus	4.6%
148	Parkinson Disease	4.6%
149	Meningoencephalitis	4.3%
150	Presenile dementia	4.2%
151	Senile dementia	4.2%
152	Huntington Disease	4.2%
153	Dandy-Walker Syndrome	4.1%
154	Pneumocephalus	4.1%
155	Poliomyelitis	4.1%
156	Myelitis	4.1%
157	Progressive bulbar palsy	4.1%
158	Bulbar palsy	4.1%
159	Chronic Fatigue Syndrome	4%
160	Psychoses, Substance-Induced	4%
161	Neuroleptic Malignant Syndrome	3.9%
162	Myelinolysis, Central Pontine	3.9%
163	Guillain-Barre Syndrome	3.9%
164	Lambert-Eaton Myasthenic Syndrome	3.9%
165	Central Nervous System Infection	3.9%
166	Myopathy	3.9%
167	Optic Neuropathy	3.9%
168	Consciousness Disorders	3.9%
169	Mental Retardation	3.9%
170	Depressed Level of Consciousness	3.9%
171	Mental deficiency	3.9%
172	Intellectual Disability	3.9%
173	Botulism	3.8%
174	Central Nervous System Cysts	3.8%
175	Facial Nerve Diseases	3.8%
176	Craniocerebral Trauma	3.8%
177	Marijuana Abuse	3.8%
178	Opioid-Related Disorders	3.8%
179	Nicotine Dependence	3.8%
180	Opioid abuse	3.8%
181	Phencyclidine Abuse	3.8%
182	Substance Abuse, Intravenous	3.8%
183	Substance Withdrawal Syndrome	3.8%
184	Tobacco Use Disorder	3.8%
185	Alcohol-Related Disorders	3.8%
186	Amphetamine-Related Disorders	3.8%
187	Cocaine-Related Disorders	3.8%
188	Vestibulocochlear Nerve Diseases	3.7%
189	Decerebrate State	3.7%
190	Gambling	3.7%
191	Hemiparesis	3.7%
192	Hydranencephaly	3.7%
193	Meningism	3.7%
194	Neural Tube Defects	3.7%
195	Paresis	3.7%
196	Premature Ejaculation	3.7%
197	Seizures	3.7%
198	Sensation Disorders	3.7%
199	Tethered Cord Syndrome	3.7%
200	Central Nervous System Neoplasms	3.7%
201	Complex partial seizures	3.7%
202	Iniencephaly	3.7%
203	Craniorachischisis	3.7%
204	Erectile dysfunction	3.7%
205	Exencephaly	3.7%
206	Monoparesis	3.7%
207	Septo-Optic Dysplasia	3.7%
208	Cortical Dysplasia	3.7%
209	Neurogenic Inflammation	3.7%
210	Gait Disorders, Neurologic	3.7%
211	Neuromuscular Manifestations	3.7%
212	Malformations of Cortical Development	3.7%
213	Sweating, Gustatory	3.7%
214	Auriculotemporal Syndrome	3.7%
215	Causalgia	3.5%
216	Creutzfeldt-Jakob disease	3.5%
217	Dyskinesia, Drug-Induced	3.5%
218	Epidural Abscess	3.5%
219	Olfactory Nerve Injuries	3.5%
220	Striatonigral Degeneration	3.5%
221	Progressive supranuclear palsy	3.4%
222	Myelitis, Transverse	3.4%
223	Mutism	3.4%
224	Selective Mutism	3.4%
225	MPTP Poisoning	3.4%
226	Akathisia, Drug-Induced	3.3%
227	Opsoclonus-Myoclonus Syndrome	3.3%
228	Amnesia	3.3%
229	Delirium	3.3%
230	Horner Syndrome	3.3%
231	Dissociative Amnesia	3.3%
232	Global Amnesia	3.3%
233	Brain Injuries	3.3%
234	Brain Neoplasms	3.2%
235	Multiple Sclerosis	3.2%
236	Spinal Cord Neoplasms	3.2%
237	Encephalomyelitis, Acute Disseminated	3.2%
238	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	3.2%
239	Reflex Sympathetic Dystrophy	3.2%
240	Subdural Effusion	3.2%
241	Parkinsonian Disorders	3.2%
242	Kluver-Bucy Syndrome	3.2%
243	Leukoencephalitis, Acute Hemorrhagic	3.1%
244	Pupil Disorders	3.1%
245	Neurobehavioral Manifestations	3.1%
246	Neuromyelitis Optica	3.1%
247	Neonatal Abstinence Syndrome	3.1%
248	Alcohol Withdrawal Delirium	3.1%
249	Facial Nerve Injuries	3%
250	Paraneoplastic Encephalomyelitis	3%
251	Shy-Drager Syndrome	3%
252	Miller Fisher Syndrome	3%
253	Uveomeningoencephalitic Syndrome	3%
254	Dystonia Musculorum Deformans	3%
255	Sturge-Weber Syndrome	3%
256	Vertigo	3%
257	Alcohol-Induced Disorders, Nervous System	3%
258	Dyspareunia	3%
259	Vasculitis, Central Nervous System	2.8%
260	Amnesia, Transient Global	2.8%
261	Dementia, Vascular	2.8%
262	Brain Abscess	2.7%
263	Ophthalmoplegia	2.7%
264	External Ophthalmoplegia	2.7%
265	Akinetic Mutism	2.7%
266	Anoxic Encephalopathy	2.7%
267	Arachnoiditis	2.7%
268	Basal Ganglia Diseases	2.7%
269	Brain Damage, Chronic	2.7%
270	Cerebellar Diseases	2.7%
271	Combat Disorders	2.7%
272	Dysthymic Disorder	2.7%
273	Encephalitis	2.7%
274	Encephalomalacia	2.7%
275	Epilepsy	2.7%
276	Hydrocephalus	2.7%
277	Congenital Hydrocephalus	2.7%
278	Hypothalamic Diseases	2.7%
279	Hysteria	2.7%
280	Aseptic Meningitis	2.7%
281	Neuritis	2.7%
282	Polyneuritis	2.7%
283	Radiculitis	2.7%
284	Schizophrenia, Catatonic	2.7%
285	Schizophrenia, Disorganized	2.7%
286	Post-Traumatic Stress Disorder	2.7%
287	Syringomyelia	2.7%
288	Thalamic Diseases	2.7%
289	Attention Deficit Disorder	2.7%
290	Seasonal Affective Disorder	2.7%
291	Conduct Disorder	2.7%
292	Social Communication Disorder	2.7%
293	Intracranial Hypertension	2.7%
294	Polyneuropathy	2.7%
295	Mononeuritis	2.7%
296	Aura	2.7%
297	Leukoencephalopathy	2.7%
298	Essential Tremor	2.7%
299	Neuroaxonal Dystrophies	2.7%
300	Familial Tremor	2.7%
301	Headache Disorders	2.7%
302	Mononeuropathies	2.7%
303	Intracranial Hypotension	2.7%
304	Brachial Plexus Neuropathies	2.7%
305	Radiculopathy	2.7%
306	Mononeuropathy Multiplex	2.7%
307	Nerve Root Compression	2.7%
308	Brain Edema	2.7%
309	Brain Hypoxia	2.7%
310	Aqueductal Stenosis	2.7%
311	Psychological Trauma	2.7%
312	Pneumorrhachis	2.7%
313	Hoarding Disorder	2.7%
314	Phonological Disorder	2.7%
315	Writer's Cramp	2.7%
316	Scrapie	2.6%
317	Central Cord Syndrome	2.6%
318	Myasthenia Gravis, Autoimmune, Experimental	2.6%
319	Leukoencephalopathy, Progressive Multifocal	2.6%
320	Meningitis, Bacterial	2.6%
321	Meningitis, Fungal	2.6%
322	Tuberous Sclerosis	2.6%
323	Chorea	2.6%
324	Acrodynia	2.6%
325	Limbic Encephalitis	2.5%
326	Voice Disorders	2.5%
327	Voice Disturbance	2.5%
328	Smith-Magenis syndrome	2.5%
329	Enuresis	2.5%
330	Dural Arteriovenous Fistula	2.5%
331	Epilepsy, Post-Traumatic	2.4%
332	Meige Syndrome	2.4%
333	Brachial Plexus Neuritis	2.4%
334	Neuralgic Amyotrophy	2.4%
335	Cerebral Ventriculitis	2.4%
336	Vocal Cord Paralysis	2.4%
337	Charcot-Marie-Tooth Disease	2.3%
338	Dyscalculia	2.2%
339	Auditory Perceptual Disorders	2.2%
340	Ataxia Telangiectasia	2.2%
341	Amblyopia	2.2%
342	Myotonia Congenita	2.2%
343	Canavan Disease	2.2%
344	Alexander Disease	2.2%
345	Psychoses, Alcoholic	2.2%
346	Paraneoplastic Cerebellar Degeneration	2.2%
347	Cerebrospinal Fluid Otorrhea	2.2%
348	Cerebrospinal Fluid Rhinorrhea	2.2%
349	Neuritis, Autoimmune, Experimental	2.2%
350	Gait Ataxia	2.1%
351	Frontotemporal dementia	2.1%
352	Lupus Vasculitis, Central Nervous System	2.1%
353	Reflex, Abnormal	2.1%
354	Hyporeflexia	2.1%
355	Hyperreflexia	2.1%
356	Brain Death	2.1%
357	Coma, Post-Head Injury	2.1%
358	Brain Diseases, Metabolic	2.1%
359	Cerebrovascular Disorders	2.1%
360	Myositis	2.1%
361	Optic Atrophy	2.1%
362	Optic Neuritis	2.1%
363	Papilledema	2.1%
364	Strabismus	2.1%
365	Tolosa-Hunt Syndrome	2.1%
366	Cerebrovascular Insufficiency	2.1%
367	Isaacs syndrome	2.1%
368	Arsenic Poisoning	2.1%
369	Myotonic Disorders	2.1%
370	Central Nervous System Fungal Infections	2.1%
371	Conus Medullaris Syndrome	2.1%
372	Myasthenic Syndromes, Congenital	2.1%
373	Spinal Cord Vascular Diseases	2.1%
374	Alexia	2.1%
375	Dyslexia	2.1%
376	Alcohol Use Disorder	2%
377	Alcoholic Intoxication	2%
378	Diabetic Neuropathies	2%
379	Facial Injuries	2%
380	Facial Neuralgia	2%
381	Heroin Dependence	2%
382	Morphine Dependence	2%
383	Alcohol abuse	2%
384	Depression, Postpartum	2%
385	Diabetic Amyotrophy	2%
386	Diabetic Autonomic Neuropathy	2%
387	Manganese Poisoning	2%
388	Orthostatic intolerance	2%
389	Alcohol Withdrawal Seizures	2%
390	Anosmia	2%
391	Ataxia	2%
392	Athetosis	2%
393	Catalepsy	2%
394	Dystonia	2%
395	Hemiplegia	2%
396	Locked-In Syndrome	2%
397	Meningeal Neoplasms	2%
398	Meningomyelocele	2%
399	Muscle Hypertonia	2%
400	Muscle hypotonia	2%
401	Myoclonus	2%
402	Myotonia	2%
403	Neuralgia	2%
404	Paraplegia	2%
405	Pseudobulbar Palsy	2%
406	Quadriplegia	2%
407	Spasm	2%
408	Spastic Paraplegia	2%
409	Status Epilepticus	2%
410	Taste Disorders	2%
411	Tremor	2%
412	Spina Bifida	2%
413	Monoplegia	2%
414	Hypokinesia	2%
415	Paraparesis	2%
416	Bradykinesia	2%
417	Waxy flexibility	2%
418	Action Tremor	2%
419	Resting Tremor	2%
420	Dysosmia	2%
421	Quadriparesis	2%
422	Premenstrual Dysphoric Disorder	2%
423	Mercury Poisoning, Nervous System	2%
424	Olfaction Disorders	2%
425	Myokymia	2%
426	Lead Poisoning, Nervous System	2%
427	Vestibular Neuronitis	2%
428	Somatosensory Disorders	2%
429	Neuropathic pain	2%
430	Hyperkinesia	2%
431	Intention tremor	2%
432	Lafora Disease	2%
433	Unverricht-Lundborg Syndrome	2%
434	Alexia, Pure	2%
435	Tarsal Tunnel Syndrome	2%
436	Cauda Equina Syndrome	2%
437	Posterior Leukoencephalopathy Syndrome	2%
438	Posterior reversible encephalopathy syndrome	2%
439	Basal Ganglia Cerebrovascular Disease	1.9%
440	Brain Injuries, Diffuse	1.9%
441	Traumatic Brain Injury	1.9%
442	Cerebellar Ataxia	1.9%
443	Supratentorial Neoplasms	1.9%
444	Torticollis	1.9%
445	Multiple Sclerosis, Chronic Progressive	1.9%
446	Multiple Sclerosis, Relapsing-Remitting	1.9%
447	Hepatolenticular Degeneration	1.9%
448	Retrograde amnesia	1.9%
449	Amnesia, Anterograde	1.9%
450	Brain Hemorrhage, Traumatic	1.9%
451	Cerebellar Neoplasms	1.9%
452	Wernicke Encephalopathy	1.9%
453	AIDS Dementia Complex	1.8%
454	Akathisia	1.8%
455	Restlessness	1.8%
456	Psychomotor Agitation	1.8%
457	Friedreich Ataxia	1.8%
458	Carotid Artery Injuries	1.8%
459	Myotonic Dystrophy	1.8%
460	Hand-Arm Vibration Syndrome	1.7%
461	Vision Disorders	1.7%
462	Metamorphopsia	1.7%
463	Visual Impairment	1.7%
464	Fibromyalgia	1.7%
465	Optic Neuropathy, Ischemic	1.7%
466	Anterior Ischemic Optic Neuropathy	1.7%
467	Central Nervous System Bacterial Infections	1.7%
468	Medial Tibial Stress Syndrome	1.7%
469	Facial Hemiatrophy	1.7%
470	Melkersson-Rosenthal Syndrome	1.7%
471	Mitochondrial Myopathies	1.7%
472	Anisocoria	1.6%
473	Confusion	1.6%
474	Facial paralysis	1.6%
475	Lethargy	1.6%
476	Memory Disorders	1.6%
477	Muscle Cramp	1.6%
478	Perceptual Disorders	1.6%
479	Psychomotor Disorders	1.6%
480	Tonic Pupil	1.6%
481	Eosinophilia-Myalgia Syndrome	1.6%
482	Anhedonia	1.6%
483	Disorientation	1.6%
484	Facial Paresis	1.6%
485	Memory Loss	1.6%
486	Hemisensory Neglect	1.6%
487	Dysacusis	1.6%
488	Anencephaly	1.6%
489	Meningocele	1.6%
490	Muscular Atrophy	1.6%
491	Respiratory Paralysis	1.6%
492	Binge Drinking	1.6%
493	Encephalocele	1.6%
494	Leukomalacia, Periventricular	1.6%
495	Vertebral Artery Dissection	1.6%
496	Tetany	1.6%
497	Carpal Tunnel Syndrome	1.6%
498	Vascular Headaches	1.6%
499	Gait Apraxia	1.6%
500	neurofibroma	1.6%
501	Hypoxia-Ischemia, Brain	1.6%
502	Autistic Disorder	1.6%
503	Cerebral Palsy	1.6%
504	Epilepsies, Partial	1.6%
505	Epilepsy, Generalized	1.6%
506	Pseudotumor Cerebri	1.6%
507	Sciatic Neuropathy	1.6%
508	Hypertensive Encephalopathy	1.6%
509	Ulnar Neuropathies	1.6%
510	Lesion of Sciatic Nerve	1.6%
511	Simple Partial Seizures	1.6%
512	Asperger Syndrome	1.6%
513	Epilepsy, Reflex	1.6%
514	Ulnar Neuritis	1.6%
515	Radial nerve compression	1.6%
516	Radial Tunnel Syndrome	1.6%
517	Peroneal Neuropathies	1.6%
518	Radial Neuropathy	1.6%
519	Median Neuropathy	1.6%
520	Sciatic Nerve Palsy	1.6%
521	Femoral Neuropathy	1.6%
522	Tibial Neuropathy	1.6%
523	Ulnar Nerve Palsy	1.6%
524	Postural Orthostatic Tachycardia Syndrome	1.6%
525	Radial nerve palsy	1.6%
526	Headache Disorders, Primary	1.6%
527	Headache Disorders, Secondary	1.6%
528	Medication overuse headache	1.6%
529	Sciatica	1.6%
530	Tardive Dyskinesia	1.6%
531	Tuberculosis, Meningeal	1.6%
532	Persistent Vegetative State	1.6%
533	Myoclonic Epilepsy	1.6%
534	Epilepsy, Temporal Lobe	1.6%
535	Epilepsy, Rolandic	1.6%
536	Benign Rolandic Epilepsy	1.6%
537	Alice in Wonderland Syndrome	1.5%
538	Refsum Disease	1.5%
539	Alstrom Syndrome	1.5%
540	Acoustic Neuroma	1.5%
541	Optic Nerve Glioma	1.5%
542	Toxoplasmosis, Cerebral	1.4%
543	Amyloid Neuropathies, Familial	1.4%
544	Brain Concussion	1.4%
545	Duane Retraction Syndrome	1.4%
546	Muscle Weakness	1.4%
547	Mitochondrial Encephalomyopathies	1.4%
548	Pick Disease of the Brain	1.4%
549	Mobius Syndrome	1.4%
550	Bell Palsy	1.4%
551	Catatonia	1.4%
552	Herpes Zoster Oticus	1.4%
553	Familial Periodic Paralysis	1.4%
554	Aphonia	1.4%
555	Dysphonia	1.4%
556	Meningitis, Cryptococcal	1.3%
557	Diurnal Enuresis	1.3%
558	Meningitis, Listeria	1.3%
559	Meningitis, Haemophilus	1.3%
560	Meningitis, Pneumococcal	1.3%
561	Cubital Tunnel Syndrome	1.3%
562	Pituitary Diseases	1.3%
563	Diffuse Axonal Injury	1.3%
564	Brain Stem Neoplasms	1.3%
565	Giant Cell Arteritis	1.3%
566	Temporal Arteritis	1.3%
567	Thoracic Outlet Syndrome	1.2%
568	Carotid Artery Diseases	1.2%
569	Brain Ischemia	1.2%
570	Esotropia	1.2%
571	Exotropia	1.2%
572	Hypotension, Orthostatic	1.2%
573	Cerebrovascular accident	1.2%
574	Polymyositis	1.2%
575	Vasospasm, Intracranial	1.2%
576	Spinal Cord Ischemia	1.2%
577	Intracranial Arterial Diseases	1.2%
578	Post-Exercise Hypotension	1.2%
579	Trigeminal Nerve Disorder	1.2%
580	Dermal Sinus	1.2%
581	Dysgeusia	1.2%
582	Formication	1.2%
583	Hyperalgesia	1.2%
584	Hyperesthesia	1.2%
585	Hypesthesia	1.2%
586	Language Disorders	1.2%
587	Numbness	1.2%
588	Paresthesia	1.2%
589	Paraparesis, Spastic	1.2%
590	Spina Bifida Cystica	1.2%
591	Trismus	1.2%
592	Spina Bifida Occulta	1.2%
593	Epilepsia Partialis Continua	1.2%
594	Hypogeusia	1.2%
595	Meningeal Carcinomatosis	1.2%
596	Brown-Sequard Syndrome	1.2%
597	Lissencephaly	1.2%
598	Polymicrogyria	1.2%
599	Pachygyria	1.2%
600	Schizencephaly	1.2%
601	Lockjaw	1.2%
602	Allodynia	1.2%
603	Lead Poisoning, Nervous System, Childhood	1.2%
604	Lead Poisoning, Nervous System, Adult	1.2%
605	Periventricular Nodular Heterotopia	1.2%
606	Ageusia	1.2%
607	Tuberculosis, Central Nervous System	1.2%
608	Juvenile Myoclonic Epilepsy	1.2%
609	Myoclonic Epilepsies, Progressive	1.2%
610	Myalgia	1.2%
611	Neuronal Ceroid-Lipofuscinoses	1.2%
612	Pituitary Adenoma	1.1%
613	Pituitary Neoplasms	1.1%
614	Classical Lissencephalies and Subcortical Band Heterotopias	1.1%
615	Adrenoleukodystrophy	1.1%
616	Basal Ganglia Hemorrhage	1.1%
617	Pituitary Apoplexy	1.1%
618	Brain Contusion	1.1%
619	Brain Infarction	1.1%
620	Subarachnoid Hemorrhage, Traumatic	1.1%
621	Carotid Artery, Internal, Dissection	1.1%
622	Polyradiculopathy	1.1%
623	Post-Traumatic Headache	1.1%
624	Tension Headache	1.1%
625	Epilepsy, Complex Partial	1.1%
626	Migraine Disorders	1.1%
627	Abdominal Migraine	1.1%
628	Status Migrainosus	1.1%
629	Cervicogenic Headache	1.1%
630	Aicardi's syndrome	1%
631	Hoarseness	1%
632	Cockayne Syndrome	1%
633	Eye Injuries	1%
634	Subacute Sclerosing Panencephalitis	1%
635	Muscular Dystrophy	1%
636	Congenital nystagmus	1%
637	Orbital Myositis	1%
638	Diplopia	1%
639	Muscle Rigidity	1%
640	Muscle Spasticity	1%
641	Scotoma	1%
642	Photophobia	1%
643	Cogwheel Rigidity	1%
644	Hemifacial Spasm	1%
645	Amaurosis	1%
646	Blindness	1%
647	Nuchal Rigidity	1%
648	Reye Syndrome	1%
649	Neuroaspergillosis	1%
650	Pyomyositis	1%
651	Intracranial Embolism and Thrombosis	1%
652	Hepatic Encephalopathy	1%
653	Agnosia	1%
654	Apraxias	1%
655	Hallucinations	1%
656	Hemianopsia	1%
657	Hyperacusis	1%
658	Tinnitus	1%
659	Visual Agnosia	1%
660	Anosognosia	1%
661	Wernicke-Korsakoff Syndrome	1%
662	Phonophobia	1%
663	Hearing Loss	1%
664	Sarcopenia	1%
665	Choroid Plexus Papilloma	0.9%
666	Holoprosencephaly	0.9%
667	Hematoma, Subdural	0.9%
668	Hematoma, Epidural, Cranial	0.9%
669	Optic Atrophy, Hereditary, Leber	0.9%
670	MELAS Syndrome	0.9%
671	Pseudorabies	0.9%
672	Putaminal Hemorrhage	0.8%
673	Color blindness	0.8%
674	Empty Sella Syndrome	0.8%
675	Hyperpituitarism	0.8%
676	Hypopituitarism	0.8%
677	Hypophysitis	0.8%
678	Cri-du-Chat Syndrome	0.8%
679	Down Syndrome	0.8%
680	Brain Diseases, Metabolic, Inborn	0.8%
681	Trisomy 21	0.8%
682	POEMS Syndrome	0.8%
683	Meningioma	0.8%
684	Williams Syndrome	0.8%
685	Microcephaly	0.8%
686	Macrocephaly	0.8%
687	Neurosyphilis	0.8%
688	Hypokalemic periodic paralysis	0.8%
689	Kearns-Sayre syndrome	0.8%
690	Moyamoya Disease	0.8%
691	Porencephaly	0.8%
692	Cerebral Arterial Diseases	0.8%
693	Vertebrobasilar Insufficiency	0.8%
694	Anterior Spinal Artery Syndrome	0.8%
695	Basilar Artery Stenosis	0.8%
696	Vertebral Artery Stenosis	0.8%
697	Intracranial Hemorrhage, Hypertensive	0.8%
698	Transient Cerebral Ischemia	0.8%
699	Trigeminal Neuralgia	0.8%
700	Agraphia	0.8%
701	Anomia	0.8%
702	Cluttering	0.8%
703	Language Development Disorders	0.8%
704	Speech Disorders	0.8%
705	Syncope	0.8%
706	Stupor	0.8%
707	Dysgraphia	0.8%
708	Presyncope	0.8%
709	Dyslalia	0.8%
710	Neurofibrosarcoma	0.8%
711	Cerebral Infarction	0.8%
712	Cluster Headache	0.8%
713	Migraine with Aura	0.8%
714	Familial Hemiplegic Migraine	0.8%
715	Chronic Paroxysmal Hemicrania	0.8%
716	Brain Stem Infarctions	0.8%
717	SUNCT Syndrome	0.8%
718	Paroxysmal Hemicrania	0.8%
719	Infarction, Middle Cerebral Artery	0.8%
720	Infarction, Anterior Cerebral Artery	0.8%
721	Infarction, Posterior Cerebral Artery	0.8%
722	Prader-Willi Syndrome	0.7%
723	Phantom pain	0.7%
724	Phantom Limb Pain	0.7%
725	Lyme Neuroborreliosis	0.7%
726	West Nile Fever	0.7%
727	Lateral Medullary Syndrome	0.7%
728	Toxoplasmosis, Congenital	0.7%
729	Eye Burns	0.6%
730	Malaria, Cerebral	0.6%
731	Hematoma, Subdural, Intracranial	0.6%
732	Hematoma, Subdural, Chronic	0.6%
733	Hematoma, Subdural, Acute	0.6%
734	Carotid Stenosis	0.6%
735	Intracranial Aneurysm	0.6%
736	Welander Distal Myopathy	0.6%
737	Neurocysticercosis	0.6%
738	Amaurosis Fugax	0.6%
739	Blindness, Cortical	0.6%
740	Intracranial Arteriosclerosis	0.6%
741	Cerebral Atherosclerosis	0.6%
742	Rett Syndrome	0.6%
743	Subarachnoid Hemorrhage	0.6%
744	Cerebral Arteriosclerosis	0.6%
745	Cerebral Hemorrhage	0.6%
746	Cerebral Thrombosis	0.6%
747	Intracranial Embolism	0.6%
748	Intracranial Thrombosis	0.6%
749	Deafness	0.6%
750	Hearing Loss, Sudden	0.6%
751	Gerstmann Syndrome	0.6%
752	Hearing Loss, Bilateral	0.6%
753	Hearing Loss, High-Frequency	0.6%
754	Hearing Loss, Mixed Conductive-Sensorineural	0.6%
755	Prosopagnosia	0.6%
756	Apraxia, Ideomotor	0.6%
757	Charles Bonnet Syndrome	0.6%
758	Hearing Loss, Unilateral	0.6%
759	Complete Hearing Loss	0.6%
760	Alien Hand Syndrome	0.6%
761	Deaf Mutism	0.6%
762	Kernicterus	0.6%
763	Hyperprolactinemia	0.6%
764	Subclavian Steal Syndrome	0.6%
765	Aphasia	0.6%
766	Articulation Disorders	0.6%
767	Echolalia	0.6%
768	Stuttering	0.6%
769	Dysphasia	0.6%
770	Dermatomyositis	0.6%
771	Corneal Scar	0.5%
772	Rubinstein-Taybi Syndrome	0.5%
773	Muscular Dystrophy, Duchenne	0.5%
774	Menkes Kinky Hair Syndrome	0.5%
775	Carotid Artery Thrombosis	0.5%
776	Waterhouse-Friderichsen Syndrome	0.5%
777	Dysarthria	0.5%
778	Acromegaly	0.5%
779	Cerebral Amyloid Angiopathy	0.5%
780	Sinus Thrombosis, Intracranial	0.5%
781	Fragile X Syndrome	0.5%
782	Corneal Perforation	0.4%
783	Galactosemias	0.4%
784	Urea Cycle Disorders, Inborn	0.4%
785	Tyrosinemias	0.4%
786	Cavernous Sinus Thrombosis	0.4%
787	Sagittal Sinus Thrombosis	0.4%
788	Fabry Disease	0.4%
789	Homocystinuria	0.4%
790	Leigh Disease	0.4%
791	Prolactinoma	0.3%
792	Growth Hormone-Secreting Pituitary Adenoma	0.3%
793	Nelson Syndrome	0.3%
794	Mucopolysaccharidosis II	0.3%
795	Zellweger Syndrome	0.3%
796	Carbamoyl-Phosphate Synthase I Deficiency Disease	0.3%
797	Glycogen storage disease type II	0.2%
798	Gaucher Disease	0.2%
799	Tay-Sachs Disease	0.2%
800	Niemann-Pick Disease, Type C	0.1%

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