MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Ketosis

(UMLS:C0022638)

Definition:: A condition characterized by an abnormally elevated concentration of KETONE BODIES in the blood (acetonemia) or urine (acetonuria). It is a sign of DIABETES COMPLICATION, starvation, alcoholism or a mitochondrial metabolic disturbance (e.g., MAPLE SYRUP URINE DISEASE).
UMLS ID:: C0022638
MeSH ID:: D007662

Classification:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.076.176.652

Synonym(s)

Ketosis

High levels of ketone bodies

Hyperketosis

KETOSIS

Ketosis, NOS

ketosis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	empagliflozin	FAERS: 10		US FAERS
2	insulin glulisine	FAERS: 9		US FAERS
3	2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol	FAERS: 5		US FAERS
4	Acetaminophen	FAERS: 5		US FAERS
5	Aripiprazole	FAERS: 5		US FAERS
6	Canagliflozin	FAERS: 5		US FAERS
7	Insulin Glargine	FAERS: 4 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
8	Olanzapine	FAERS: 4		SIDER US FAERS
9	Quetiapine Fumarate	FAERS: 4		US FAERS
10	Sitagliptin Phosphate	FAERS: 4		US FAERS
11	Everolimus	FAERS: 3		US FAERS
12	Metformin	FAERS: 3		US FAERS
13	Metformin	FAERS: 3		US FAERS
14	miglitol	FAERS: 3		US FAERS
15	Deferasirox	FAERS: 2		US FAERS
16	Exenatide	FAERS: 2		US FAERS
17	Fulvestrant	FAERS: 2		US FAERS
18	Gabapentin	FAERS: 2		US FAERS
19	Insulin Lispro	FAERS: 2		US FAERS
20	Sevelamer	FAERS: 2		US FAERS
21	Varenicline	FAERS: 2		US FAERS
22	Zanamivir	FAERS: 2		US FAERS
23	Amoxicillin	FAERS: 1		US FAERS
24	Azithromycin	FAERS: 1		US FAERS
25	Clozapine	FAERS: 1	19222986	CTD US FAERS
26	Diazoxide	FAERS: 1		US FAERS
27	Dipyrone	FAERS: 1		US FAERS
28	Esomeprazole	FAERS: 1		US FAERS
29	Insulin degludec	FAERS: 1		US FAERS
30	Levetiracetam	FAERS: 1		US FAERS
31	Liraglutide	FAERS: 1		US FAERS
32	Micafungin	FAERS: 1		US FAERS
33	Prednisolone	FAERS: 1		US FAERS
34	Propranolol	FAERS: 1		US FAERS
35	Risperidone	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
36	Sodium Oxybate	FAERS: 1		US FAERS
37	Tacrolimus	FAERS: 1		US FAERS
38	Trimethoprim, Sulfamethoxazole Drug Combination	FAERS: 1		US FAERS
39	aliskiren	FAERS: 1		US FAERS
40	clevidipine	FAERS: 1		US FAERS
41	niraparib	FAERS: 1		US FAERS
42	semaglutide	FAERS: 1		US FAERS
43	silodosin	FAERS: 1		US FAERS
44	1,3-butylene glycol		View details 1500562 1787195 2219211 2628443 2677071 3726892 3810756 4026018 4049449 6138230 6497141 6501647 6501648 6746436 6785157 8263521 9276795	CTD
45	Acetone		6138230	CTD
46	Albuterol			SIDER
47	Aspirin		3590391	CTD
48	Dexamethasone	Canada Vigilance: 1		Canada Vigilance
49	Doxorubicin			SIDER
50	Niacin		6497141	CTD
51	Paroxetine			SIDER
52	Phenytoin			SIDER
53	Phlorhizin		6497141	CTD
54	Prednisone	Canada Vigilance: 1	3703509	CTD Canada Vigilance
55	Pregabalin			SIDER
56	Streptozocin		29420703	CTD
57	Valproic Acid		2121122	CTD
58	fosphenytoin			SIDER
59	zaleplon			SIDER
60	ziprasidone			SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Acidosis, Lactic	48.4%
2	Alkalosis	34.4%
3	Acidosis, Respiratory	32.6%
4	Calcium Metabolism Disorders	25.4%
5	Iron Metabolism Disorders	25.4%
6	Phosphorus Metabolism Disorders	25.4%
7	Water-Electrolyte Imbalance	25.4%
8	Lipid Metabolism Disorders	25.4%
9	Mitochondrial Diseases	25.4%
10	Glucose Metabolism Disorders	25.4%
11	Achlorhydria	23.1%
12	Wasting Syndrome	23%
13	Hypercalcemia	19.8%
14	Hypocalcemia	19.8%
15	Milk-Alkali Syndrome	19.8%
16	Renal tubular acidosis	19.3%
17	Osteopenia	17.2%
18	Brain Diseases, Metabolic	16.9%
19	Nutrition Disorders	16.4%
20	Alkalosis, Respiratory	15.2%
21	Lipodystrophy	14.9%
22	Amyloidosis	14.8%
23	Calcinosis	14.8%
24	Hyperglycemia	14.8%
25	Hyperinsulinism	14.8%
26	Hyperkalemia	14.8%
27	Hypernatremia	14.8%
28	Hypoglycemia	14.8%
29	Hypokalemia	14.8%
30	Hyponatremia	14.8%
31	Xanthomatosis	14.8%
32	Hypophosphatemia	14.8%
33	Dyslipidemias	14.8%
34	Iron Overload	14.8%
35	Xanthoma	14.8%
36	Pseudohypoparathyroidism	13.1%
37	Rickets	12.6%
38	Brain Diseases, Metabolic, Inborn	11.8%
39	Diabetes Mellitus	10.6%
40	Hyperhomocysteinemia	10.5%
41	Leigh Disease	10.3%
42	Dehydration	10.1%
43	Lipomatosis	10.1%
44	Water Intoxication	10.1%
45	Werner Syndrome	10.1%
46	Amino Acid Metabolism, Inborn Errors	9.9%
47	Bloom Syndrome	9.9%
48	Carbohydrate Metabolism, Inborn Errors	9.9%
49	Metal Metabolism, Inborn Errors	9.9%
50	Osteoporosis	9.9%
51	Progeria	9.9%
52	Lysosomal Storage Diseases	9.9%
53	Bone Demineralization, Pathologic	9.9%
54	Cytochrome-c Oxidase Deficiency	9.9%
55	Peroxisomal Disorders	9.9%
56	Post-Traumatic Osteoporosis	9.9%
57	Celiac Disease	9.8%
58	Sprue, Tropical	9.8%
59	Steatorrhea	9.8%
60	Sprue	9.8%
61	Lactose Intolerance	9.7%
62	Calciphylaxis	9.7%
63	Hemosiderosis	9.7%
64	Hypolipoproteinemias	9.7%
65	Vascular calcification	9.7%
66	Carbamoyl-Phosphate Synthase I Deficiency Disease	9%
67	Hyperlipoproteinemia Type IV	8.6%
68	Hyperlipoproteinemia Type V	8.6%
69	Child Nutrition Disorders	8.5%
70	Hypervitaminosis A	8.5%
71	Infant Nutrition Disorders	8.5%
72	Malnutrition	8.5%
73	Hyperlipidemia, Familial Combined	8.4%
74	Osteomalacia	8.4%
75	Smith-Lemli-Opitz Syndrome	8.3%
76	Galactosemias	8.3%
77	Urea Cycle Disorders, Inborn	8.3%
78	Tyrosinemias	8.3%
79	Mitochondrial Encephalomyopathies	8.2%
80	Congenital Hyperinsulinism	8.1%
81	Hyperlipoproteinemia Type III	7.8%
82	Mitochondrial Myopathies	7.6%
83	Myelinolysis, Central Pontine	7.5%
84	Glycosuria	7.4%
85	Reye Syndrome	7.4%
86	Hepatic Encephalopathy	7.3%
87	Hyperphosphaturia	7.2%
88	Hypercholesterolemia	7.2%
89	Hyperlipoproteinemias	7.2%
90	Hypertriglyceridemia	7.2%
91	Hypoalphalipoproteinemias	7.2%
92	Familial Hypophosphatemic Rickets	6.8%
93	Homocystinuria	6.7%
94	HIV Wasting Syndrome	6.5%
95	Adiposis Dolorosa	6.5%
96	Alkaptonuria	6.5%
97	Glycogen Storage Disease	6.5%
98	Hypophosphatasia	6.5%
99	Insulin Resistance	6.5%
100	Osteoporosis, Postmenopausal	6.5%
101	Propionic acidemia	6.5%
102	Dihydropyrimidine Dehydrogenase Deficiency	6.5%
103	Cystinosis	6.5%
104	Glycogen storage disease type II	6.4%
105	Gaucher Disease	6.2%
106	Amyloid Neuropathies, Familial	6.1%
107	Porphyrias, Hepatic	6%
108	Necrobiosis Lipoidica Diabeticorum	5.9%
109	Fanconi Anemia	5.8%
110	Nesidioblastosis	5.8%
111	Neuronal Ceroid-Lipofuscinoses	5.7%
112	HIV-Associated Lipodystrophy Syndrome	5.5%
113	Wernicke Encephalopathy	5.5%
114	Zellweger Syndrome	5.3%
115	Renal Osteodystrophy	5.3%
116	Renal rickets	5.3%
117	MELAS Syndrome	5.3%
118	Menkes Kinky Hair Syndrome	5.3%
119	Adrenoleukodystrophy	5.1%
120	Gestational Diabetes	5.1%
121	Latent Autoimmune Diabetes in Adults	5.1%
122	Tay-Sachs Disease	5.1%
123	Diabetes Mellitus, Experimental	5%
124	Niemann-Pick Disease, Type C	4.9%
125	Deficiency Diseases	4.9%
126	Starvation	4.9%
127	Refeeding Syndrome	4.9%
128	Hepatolenticular Degeneration	4.9%
129	Nephrocalcinosis	4.9%
130	Tetany	4.9%
131	Diabetic Ketoacidosis	4.9%
132	Friedreich Ataxia	4.9%
133	Refsum Disease	4.8%
134	Glycosuria, Renal	4.8%
135	Cerebral Amyloid Angiopathy	4.8%
136	Glycogen Storage Disease Type I	4.8%
137	Glycogen Storage Disease Type V	4.8%
138	Mucopolysaccharidosis III	4.8%
139	Fabry Disease	4.8%
140	Kernicterus	4.3%
141	Cockayne Syndrome	4.2%
142	Familial Periodic Paralysis	4%
143	Primary amyloidosis	3.9%
144	Kearns-Sayre syndrome	3.9%
145	Variegate Porphyria	3.9%
146	Acute intermittent porphyria	3.9%
147	Porphyria Cutanea Tarda	3.9%
148	Renal Aminoacidurias	3.9%
149	Fanconi Syndrome	3.9%
150	Pseudohypoaldosteronism	3.9%
151	Liddle Syndrome	3.9%
152	Ataxia Telangiectasia	3.8%
153	Optic Atrophy, Hereditary, Leber	3.7%
154	Sjogren-Larsson Syndrome	3.4%
155	Xeroderma Pigmentosum	3.3%
156	Gout	3.3%
157	Amyotrophic Lateral Sclerosis	3.3%
158	Antley-Bixler Syndrome Phenotype	3.2%
159	Canavan Disease	3.2%
160	Alexander Disease	3.2%
161	Kwashiorkor	3.2%
162	Magnesium Deficiency	3.2%
163	Potassium Deficiency	3.2%
164	Protein Deficiency	3.2%
165	Avitaminosis	3.2%
166	Mucopolysaccharidosis II	3.2%
167	Hypokalemic periodic paralysis	2.9%
168	Frontotemporal dementia	2.9%
169	Cystinuria	2.9%
170	CREST Syndrome	2.8%
171	Albinism	2.5%
172	Arthritis, Gouty	2.4%
173	Ascorbic Acid Deficiency	2.4%
174	Vitamin A Deficiency	2.4%
175	Vitamin D Deficiency	2.4%
176	Vitamin E Deficiency	2.4%
177	Marasmus	2.4%
178	Folic Acid Deficiency	2%
179	Pellagra	2%
180	Thiamine Deficiency	2%
181	Vitamin B 12 Deficiency	2%
182	Vitamin B 6 Deficiency	2%
183	Pyridoxine Deficiency	2%
184	Ichthyosis, X-Linked	2%
185	Obesity	1.9%
186	Beriberi	1.8%
187	Obesity, Abdominal	1.6%
188	Pediatric Obesity	1.3%
189	Vitamin K Deficiency	1.2%
190	Anemia, Pernicious	1.2%
191	Prader-Willi Syndrome	1.1%
192	Scurvy	1%
193	Subacute Combined Degeneration	0.6%

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