MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Brachydactyly

(UMLS:C0221357)

Definition:: Congenital anomaly of abnormally short fingers or toes.
UMLS ID:: C0221357
MeSH ID:: D059327

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.660.585.262

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.621.585.262

Synonym(s)

Brachydactyly

Brachydactyly syndrome

Short fingers or toes

brachydactyly

brachydactyly was noted

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Valproic Acid	FAERS: 9	US FAERS
2	Methotrexate	FAERS: 3	US FAERS
3	Paroxetine	FAERS: 3	US FAERS
4	Isotretinoin	FAERS: 2	US FAERS
5	Mycophenolic Acid	FAERS: 2	US FAERS
6	Warfarin	FAERS: 2	US FAERS
7	Carbamazepine	FAERS: 1	US FAERS
8	Finasteride	FAERS: 1	US FAERS
9	Fluoxetine	FAERS: 1	US FAERS
10	Lamotrigine	FAERS: 1	US FAERS
11	Liraglutide	FAERS: 1	US FAERS
12	Nevirapine	FAERS: 1	US FAERS
13	Ondansetron	FAERS: 1	US FAERS
14	Quetiapine Fumarate	FAERS: 1	US FAERS
15	Valproic Acid	FAERS: 1	US FAERS
16	Glatiramer Acetate	Canada Vigilance: 1	Canada Vigilance

Similar ADE(s)

	Name	Semantic Similarity
1	Amelia	47.5%
2	Arachnodactyly	47.5%
3	Ectromelia	47.5%
4	Hemimelia	47.5%
5	Phocomelia	47.5%
6	Sirenomelia	47.5%
7	Polydactyly	47.5%
8	Lower Extremity Deformities, Congenital	47.5%
9	Upper Extremity Deformities, Congenital	47.5%
10	Syndactyly	40.3%
11	Craniofacial Abnormalities	32.8%
12	Poland Syndrome	30%
13	Arthrogryposis	29.1%
14	Pectus excavatum	28.9%
15	Acrocephalosyndactylia	28.4%
16	Klippel-Feil Syndrome	28%
17	Synostosis	28%
18	Gastroschisis	26%
19	Craniosynostosis	25.4%
20	Brachycephaly	25.4%
21	Talipes	24%
22	Pectus carinatum	23.7%
23	Plagiocephaly	21.3%
24	Congenital clubfoot	20.7%
25	Vertical Talus	20.7%
26	Maxillofacial Abnormalities	19.4%
27	Holoprosencephaly	19.4%
28	Craniofacial Dysostosis	19%
29	Platybasia	18.7%
30	Rubinstein-Taybi Syndrome	18.2%
31	Abnormalities, Drug-Induced	16.9%
32	Situs Inversus	16.9%
33	Microcephaly	16.5%
34	Macrocephaly	16.5%
35	Antley-Bixler Syndrome Phenotype	14.2%
36	Beckwith-Wiedemann Syndrome	13.9%
37	Wolf-Hirschhorn Syndrome	13.9%
38	Noonan Syndrome	13.3%
39	Eye Abnormalities	13.3%
40	Cardiovascular Abnormalities	13.3%
41	Laryngomalacia	13.2%
42	Jaw Abnormalities	13.1%
43	Porencephaly	12.9%
44	Skin Abnormalities	12.8%
45	Lymphatic Abnormalities	12.8%
46	Congenital Microtia	12.8%
47	Congenital diaphragmatic hernia	12.5%
48	Mandibulofacial Dysostosis	11.9%
49	Goldenhar Syndrome	11.9%
50	Bone Diseases	11.8%
51	Fasciitis	11.8%
52	Foot Deformities	11.8%
53	Arthropathy	11.8%
54	Smith-Magenis syndrome	11.7%
55	Cri-du-Chat Syndrome	11.5%
56	Down Syndrome	11.5%
57	Trisomy 21	11.5%
58	Aicardi's syndrome	11.3%
59	Nail-Patella Syndrome	11.3%
60	Urogenital Abnormalities	10.6%
61	Genetic Diseases, Inborn	10.6%
62	Contracture	10.3%
63	Osteoarthropathy, Secondary Hypertrophic	10.3%
64	Fasciitis, Plantar	10.3%
65	Micrognathism	10%
66	Pierre Robin Syndrome	10%
67	Ectodermal Dysplasia	10%
68	Aplasia Cutis Congenita	10%
69	Prune Belly Syndrome	9.9%
70	Twins, Conjoined	9.9%
71	Waardenburg Syndrome	9.9%
72	Anencephaly	9.9%
73	Prader-Willi Syndrome	9.9%
74	Bronchomalacia	9.8%
75	Tracheomalacia	9.8%
76	CHARGE Syndrome	9.4%
77	Prognathism	9.4%
78	Jaw Diseases	9.2%
79	Cleft Palate	9.1%
80	Marfan Syndrome	9%
81	Retrognathia	8.9%
82	Cartilage Diseases	8.8%
83	Foot Diseases	8.8%
84	Myopathy	8.8%
85	Rheumatism	8.8%
86	Chondromalacia	8.8%
87	Dural Arteriovenous Fistula	8.3%
88	Dextrocardia	8.2%
89	Fibromyalgia	8.2%
90	Osteochondritis	8.2%
91	Polymyalgia Rheumatica	8.2%
92	Metatarsalgia	8.1%
93	Fetal Diseases	8%
94	Xeroderma	7.8%
95	Mobius Syndrome	7.8%
96	Gout	7.6%
97	Anophthalmos	7.6%
98	Anus, Imperforate	7.6%
99	Hydranencephaly	7.6%
100	Microphthalmos	7.6%
101	Multiple Epiphyseal Dysplasia	7.6%
102	Neural Tube Defects	7.6%
103	Osteochondrodysplasias	7.6%
104	Tethered Cord Syndrome	7.6%
105	Iniencephaly	7.6%
106	Craniorachischisis	7.6%
107	Exencephaly	7.6%
108	Septo-Optic Dysplasia	7.6%
109	Cortical Dysplasia	7.6%
110	Malformations of Cortical Development	7.6%
111	Anorectal Malformations	7.6%
112	Bloom Syndrome	7.4%
113	Cockayne Syndrome	7.4%
114	Kartagener Syndrome	7.4%
115	Abnormalities, Radiation-Induced	7.1%
116	Osteoarthritis, Spine	6.8%
117	Arthritis	6.7%
118	Bone Diseases, Developmental	6.7%
119	Bursitis	6.7%
120	Hyperostosis	6.7%
121	Joint Instability	6.7%
122	Myofascial Pain Syndromes	6.7%
123	Osteitis	6.7%
124	Osteitis Deformans	6.7%
125	Osteochondrosis	6.7%
126	Rhabdomyolysis	6.7%
127	Spinal Diseases	6.7%
128	Synovitis	6.7%
129	Joint laxity	6.7%
130	Polyarthritis	6.7%
131	Frozen shoulder	6.7%
132	Patellofemoral Pain Syndrome	6.7%
133	Rheumatic Fever	6.7%
134	Ischemic contracture	6.6%
135	Hip Contracture	6.6%
136	Periarthritis	6.6%
137	Polycystic Kidney Diseases	6.5%
138	Williams Syndrome	6.5%
139	Scimitar Syndrome	6.4%
140	Temporomandibular Joint Disorders	6.3%
141	Dwarfism	6.3%
142	Blepharophimosis	6.1%
143	Laryngostenosis	6.1%
144	Mouth Abnormalities	6.1%
145	Esophageal Atresia	6%
146	Intestinal Atresia	6%
147	Horseshoe Kidney	6%
148	Muscular Dystrophy	6%
149	Acrodermatitis	6%
150	Lymphangiectasis, Intestinal	6%
151	Gianotti-Crosti Syndrome	6%
152	Retinal Dysplasia	5.9%
153	Aniridia	5.8%
154	Cystic Fibrosis	5.8%
155	Osteoarthritis, Knee	5.7%
156	Epidermolysis Bullosa	5.7%
157	Ankylosing spondylitis	5.7%
158	Basal Cell Nevus Syndrome	5.7%
159	Rheumatoid Arthritis	5.6%
160	Juvenile arthritis	5.6%
161	Alstrom Syndrome	5.6%
162	Abdominal Cramps	5.6%
163	Amniotic Band Syndrome	5.6%
164	Asphyxia Neonatorum	5.6%
165	Infant, Premature, Diseases	5.6%
166	Infantile Colic	5.6%
167	Temporomandibular Joint Dysfunction Syndrome	5.6%
168	Fragile X Syndrome	5.5%
169	Osteogenesis Imperfecta	5.3%
170	Arthritis, Gouty	5.3%
171	Bone Diseases, Endocrine	5.3%
172	Gigantism	5.3%
173	Spinal Neoplasms	5.3%
174	Spondylitis	5.3%
175	Primary Ciliary Dyskinesia	5.3%
176	Smith-Lemli-Opitz Syndrome	5.3%
177	Choanal Atresia	5.1%
178	Tracheobronchomegaly	5.1%
179	Laryngocele	5.1%
180	Bone Diseases, Infectious	5.1%
181	Bone neoplasms	5.1%
182	Compartment syndromes	5.1%
183	Maxillary Diseases	5.1%
184	Osteopenia	5.1%
185	Tendinitis	5.1%
186	Tendinopathy	5.1%
187	Choledochal Cyst	5.1%
188	Hermaphroditism	5.1%
189	Disorders of Sex Development	5.1%
190	Ichthyosis, X-Linked	5.1%
191	Bone Resorption	5%
192	Hemarthrosis	5%
193	Myositis	5%
194	Tietze's Syndrome	5%
195	Isaacs syndrome	5%
196	Aseptic Necrosis of Bone	5%
197	Myotonic Disorders	5%
198	Cryptorchidism	5%
199	Hypospadias	5%
200	Central Nervous System Cysts	5%
201	Dandy-Walker Syndrome	5%
202	Ectopia Cordis	4.9%
203	Meningomyelocele	4.9%
204	Spina Bifida	4.9%
205	POEMS Syndrome	4.9%
206	Single umbilical artery	4.9%
207	Muscular Dystrophy, Duchenne	4.9%
208	Meconium Aspiration Syndrome	4.9%
209	Congenital Hypothyroidism	4.8%
210	Myotonic Dystrophy	4.7%
211	Arthritis, Psoriatic	4.7%
212	Classical Lissencephalies and Subcortical Band Heterotopias	4.7%
213	Rheumatoid Nodule	4.6%
214	Turner Syndrome	4.5%
215	Spondylarthropathies	4.5%
216	Pseudoxanthoma Elasticum	4.4%
217	Neoplastic Syndromes, Hereditary	4.4%
218	Familial Periodic Paralysis	4.4%
219	Ainhum	4.4%
220	Bunion	4.4%
221	Dysostoses	4.4%
222	Fibrodysplasia Ossificans Progressiva	4.4%
223	Myoglobinuria	4.4%
224	Myositis Ossificans	4.4%
225	Spinal Stenosis	4.4%
226	Spondylosis	4.4%
227	Tenosynovitis	4.4%
228	Intervertebral Disc Degeneration	4.4%
229	Sacroiliitis	4.4%
230	Polycystic Kidney, Autosomal Dominant	4.3%
231	Bladder Exstrophy	4.3%
232	Epispadias	4.3%
233	Multicystic Dysplastic Kidney	4.3%
234	Anemia, Neonatal	4.2%
235	Pelger-Huet Anomaly	4.2%
236	Persistent Fetal Circulation Syndrome	4.2%
237	Werner Syndrome	4.2%
238	Myasthenic Syndromes, Congenital	4.2%
239	Arthritis, Reactive	4.2%
240	Umbilical hernia	4.1%
241	Medial Tibial Stress Syndrome	4.1%
242	Mitochondrial Myopathies	4%
243	Xeroderma Pigmentosum	4%
244	Muscle Cramp	4%
245	Eosinophilia-Myalgia Syndrome	4%
246	Sjogren-Larsson Syndrome	4%
247	Muscle Rigidity	4%
248	Muscle Spasticity	4%
249	Cogwheel Rigidity	4%
250	Nuchal Rigidity	4%
251	Aortic coarctation	3.9%
252	Cor Triatriatum	3.9%
253	Coronary Vessel Anomalies	3.9%
254	Dental Enamel Hypoplasia	3.9%
255	Patent ductus arteriosus	3.9%
256	Ebstein Anomaly	3.9%
257	Heart Septal Defects	3.9%
258	Hypodontia	3.9%
259	Macrostomia	3.9%
260	Meningocele	3.9%
261	Microstomia	3.9%
262	Tetralogy of Fallot	3.9%
263	Transposition of Great Vessels	3.9%
264	Hypoplastic Left Heart Syndrome	3.9%
265	May-Thurner Syndrome	3.9%
266	Encephalocele	3.9%
267	Welander Distal Myopathy	3.9%
268	Discitis	3.9%
269	Wolff-Parkinson-White Syndrome	3.9%
270	Kallmann Syndrome	3.9%
271	Myotonia Congenita	3.8%
272	Felty Syndrome	3.8%
273	Klinefelter Syndrome	3.8%
274	Charcot-Marie-Tooth Disease	3.7%
275	Dermal Sinus	3.6%
276	Spina Bifida Cystica	3.6%
277	Spina Bifida Occulta	3.6%
278	Lissencephaly	3.6%
279	Polymicrogyria	3.6%
280	Pachygyria	3.6%
281	Schizencephaly	3.6%
282	Periventricular Nodular Heterotopia	3.6%
283	Zellweger Syndrome	3.5%
284	Chronic Fatigue Syndrome	3.5%
285	Neonatal Abstinence Syndrome	3.4%
286	Hyperkeratosis, Epidermolytic	3.4%
287	Giant Cell Epulis	3.4%
288	Muscle Weakness	3.4%
289	Arthritis, Infectious	3.4%
290	Fetal Growth Retardation	3.4%
291	Musculoskeletal Pain	3.3%
292	Fetal Hypoxia	3.3%
293	Congenital nystagmus	3.3%
294	Fetal Alcohol Spectrum Disorders	3.3%
295	Anterior Compartment Syndrome	3.3%
296	Osteomyelitis	3.3%
297	Osteoporosis	3.3%
298	Periostitis	3.3%
299	Enthesopathy	3.3%
300	Bone Demineralization, Pathologic	3.3%
301	Post-Traumatic Osteoporosis	3.3%
302	Arthritis, Experimental	3.3%
303	Abdominal Compartment Syndrome	3.3%
304	Toxoplasmosis, Congenital	3.3%
305	Arthralgia	3.3%
306	Long QT Syndrome	3.3%
307	Familial Mediterranean Fever	3.3%
308	Polyarthralgia	3.3%
309	Tricuspid Atresia	3.3%
310	Arrhythmogenic Right Ventricular Dysplasia	3.3%
311	Syphilis, Congenital	3.3%
312	Anemia, Sickle Cell	3.3%
313	Thalassemia	3.3%
314	Alveolar Bone Loss	3.3%
315	Femur Head Necrosis	3.3%
316	Gonadal Dysgenesis	3.3%
317	Polymyositis	3.3%
318	Adrenogenital Syndrome	3.3%
319	Ovotesticular Disorders of Sex Development	3.3%
320	Osteolysis	3.3%
321	Rheumatoid Vasculitis	3.3%
322	Chondrodysplasia Punctata	3.3%
323	Enchondromatosis	3.3%
324	Lordosis	3.3%
325	Osteosclerosis	3.3%
326	Spondylolysis	3.3%
327	kyphosis	3.3%
328	Kashin-Beck Disease	3.3%
329	Tuberculosis, Spinal	3.2%
330	Tuberous Sclerosis	3.2%
331	Refsum Disease	3%
332	Hypokalemic periodic paralysis	3%
333	Albinism	2.9%
334	Aortopulmonary Septal Defect	2.9%
335	Double Outlet Right Ventricle	2.9%
336	Endocardial Cushion Defects	2.9%
337	Myocardial bridging	2.9%
338	Aorticopulmonary Septal Defect	2.9%
339	Hyperandrogenism	2.9%
340	Sicca Syndrome	2.9%
341	Sjogren's Syndrome	2.9%
342	Eosinophilic Granuloma	2.8%
343	Autoimmune Lymphoproliferative Syndrome	2.8%
344	Myalgia	2.8%
345	Pseudohypoparathyroidism	2.8%
346	Congenital Hyperinsulinism	2.8%
347	Chorioamnionitis	2.8%
348	Angioedemas, Hereditary	2.7%
349	Hip Dislocation	2.7%
350	Shoulder Dislocation	2.7%
351	Hip Dysplasia	2.7%
352	Melorheostosis	2.7%
353	Osteopetrosis	2.7%
354	Spondylolisthesis	2.7%
355	Orbital Myositis	2.7%
356	Dupuytren Contracture	2.7%
357	Palatal Neoplasms	2.7%
358	Pyomyositis	2.6%
359	Acromegaly	2.6%
360	Joint Tuberculosis	2.6%
361	Tuberculosis, Osteoarticular	2.6%
362	Bone Tuberculosis	2.6%
363	Rett Syndrome	2.6%
364	Paralysis, Obstetric	2.5%
365	Retinopathy of Prematurity	2.5%
366	Amino Acid Metabolism, Inborn Errors	2.5%
367	Carbohydrate Metabolism, Inborn Errors	2.5%
368	Metal Metabolism, Inborn Errors	2.5%
369	Progeria	2.5%
370	Lysosomal Storage Diseases	2.5%
371	Cytochrome-c Oxidase Deficiency	2.5%
372	Peroxisomal Disorders	2.5%
373	Wiskott-Aldrich Syndrome	2.5%
374	Bronchopulmonary Dysplasia	2.5%
375	Osteoporosis, Postmenopausal	2.4%
376	Romano-Ward Syndrome	2.4%
377	Truncus Arteriosus, Persistent	2.4%
378	Mucopolysaccharidosis II	2.2%
379	Rickets	2.2%
380	Menkes Kinky Hair Syndrome	2.2%
381	Shoulder Pain	2.2%
382	Sickle Cell Trait	2.2%
383	Neuronal Ceroid-Lipofuscinoses	2.1%
384	Ophthalmia Neonatorum	2%
385	Respiratory Distress Syndrome, Newborn	2%
386	Cutis Laxa	2%
387	Retinitis Pigmentosa	2%
388	Pigmentary retinopathy	2%
389	Porokeratosis	2%
390	Keratoderma, Palmoplantar	2%
391	Chronic granulomatous disease	2%
392	Mastoiditis	1.9%
393	Petrositis	1.9%
394	Mitochondrial Encephalomyopathies	1.9%
395	Ataxia Telangiectasia	1.9%
396	Arteriovenous fistula	1.8%
397	Amyloid Neuropathies, Familial	1.8%
398	Hepatolenticular Degeneration	1.8%
399	Adrenoleukodystrophy	1.7%
400	Duane Retraction Syndrome	1.7%
401	Porphyrias, Hepatic	1.7%
402	Dermatomyositis	1.7%
403	Acute Chest Syndrome	1.7%
404	Peutz-Jeghers Syndrome	1.7%
405	Hydrops Fetalis	1.6%
406	Thrombasthenia	1.6%
407	Antithrombin III Deficiency	1.6%
408	Protein C Deficiency	1.6%
409	Brain Diseases, Metabolic, Inborn	1.6%
410	Afibrinogenemia	1.6%
411	Dystonia Musculorum Deformans	1.6%
412	Factor VII Deficiency	1.6%
413	Factor X Deficiency	1.6%
414	Factor XII Deficiency	1.6%
415	Hemophilia A	1.6%
416	Leukomalacia, Periventricular	1.6%
417	Activated Protein C Resistance	1.6%
418	Factor II deficiency	1.6%
419	Factor VIII Deficiency	1.6%
420	Factor V deficiency	1.6%
421	Factor XI Deficiency	1.6%
422	Hypoprothrombinemias	1.6%
423	Fanconi Anemia	1.6%
424	Nesidioblastosis	1.6%
425	Alkaptonuria	1.6%
426	Glycogen Storage Disease	1.6%
427	Hypophosphatasia	1.6%
428	Propionic acidemia	1.6%
429	Dihydropyrimidine Dehydrogenase Deficiency	1.6%
430	Cystinosis	1.6%
431	Lafora Disease	1.6%
432	Unverricht-Lundborg Syndrome	1.6%
433	Anemia, Diamond-Blackfan	1.6%
434	Galactosemias	1.6%
435	Urea Cycle Disorders, Inborn	1.6%
436	Tyrosinemias	1.6%
437	Osteomalacia	1.6%
438	Fabry Disease	1.5%
439	Denys-Drash Syndrome	1.5%
440	Multiple Endocrine Neoplasia	1.5%
441	MELAS Syndrome	1.5%
442	Canavan Disease	1.5%
443	Alexander Disease	1.5%
444	Optic Atrophy, Hereditary, Leber	1.4%
445	Glycogen storage disease type II	1.4%
446	Hyperphosphaturia	1.4%
447	Dermatitis, Atopic	1.4%
448	Mucopolysaccharidosis III	1.4%
449	Hyaline Membrane Disease	1.3%
450	Hypolipoproteinemias	1.3%
451	Papillon-Lefevre Disease	1.3%
452	Hyperlipidemia, Familial Combined	1.3%
453	Hyperlipoproteinemia Type III	1.3%
454	Homocystinuria	1.3%
455	Leigh Disease	1.3%
456	Familial Hypophosphatemic Rickets	1.3%
457	Kernicterus	1.3%
458	Behcet Syndrome	1.2%
459	Glycogen Storage Disease Type I	1.2%
460	Glycogen Storage Disease Type V	1.2%
461	Radicular Cyst	1.2%
462	Nose Neoplasms	1.1%
463	Huntington Disease	1.1%
464	Lactose Intolerance	1.1%
465	Variegate Porphyria	1.1%
466	Acute intermittent porphyria	1.1%
467	Porphyria Cutanea Tarda	1.1%
468	Hyperhomocysteinemia	1.1%
469	Gaucher Disease	1.1%
470	Renal Osteodystrophy	1.1%
471	Renal rickets	1.1%
472	Renal Aminoacidurias	1.1%
473	Fanconi Syndrome	1.1%
474	Pseudohypoaldosteronism	1.1%
475	Liddle Syndrome	1.1%
476	Hyperlipoproteinemia Type IV	1.1%
477	Hyperlipoproteinemia Type V	1.1%
478	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.1%
479	Nephroblastoma	1%
480	Hypoalphalipoproteinemias	1%
481	Multiple Endocrine Neoplasia Type 1	0.9%
482	Friedreich Ataxia	0.9%
483	Renal tubular acidosis	0.9%
484	Tay-Sachs Disease	0.9%
485	Niemann-Pick Disease, Type C	0.9%
486	Adenomatous Polyposis Coli	0.9%
487	Kearns-Sayre syndrome	0.8%
488	Cystinuria	0.8%
489	Glycosuria, Renal	0.7%

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