MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Vitamin B 12 Deficiency

(UMLS:C0042847)

Definition:: A nutritional condition produced by a deficiency of VITAMIN B 12 in the diet, characterized by megaloblastic anemia. Since vitamin B 12 is not present in plants, humans have obtained their supply from animal products, from multivitamin supplements in the form of pills, and as additives to food preparations. A wide variety of neuropsychiatric abnormalities is also seen in vitamin B 12 deficiency and appears to be due to an undefined defect involving myelin synthesis. (From Cecil Textbook of Medicine, 19th ed, p848)
UMLS ID:: C0042847
MeSH ID:: D014806

Classification:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.654.521.500.133.699.923

Synonym(s)

Vitamin B 12 Deficiency

CYANOCOBALAMIN DEFICIENCY

Cobalamin deficiency

Deficiency of vitamin B>12<

Deficiency;vitamin B12

Hypocobalaminemia

VITAMIN B 12 DEFICIENCY

VITAMIN B12 DEFICIENCY

Vitamin B12 Deficiency

10.

Vitamin B12 deficiency

11.

Vitamin B12 deficiency disease

12.

b12 deficiency disease vitamin

13.

b12 deficiency vitamin

14.

b12 deficiency vitamins

15.

b12 vitamin deficiency

Associated Drug(s)

	Name	Reference(s)	Data Source
1	1 alpha-hydroxyergocalciferol		OFFSIDES
2	Alendronate		OFFSIDES
3	Allopurinol		OFFSIDES
4	Amoxicillin		OFFSIDES
5	Atenolol		OFFSIDES
6	Azacitidine		OFFSIDES
7	Bimatoprost		OFFSIDES
8	Bortezomib		OFFSIDES
9	Bupropion		OFFSIDES
10	Carisoprodol		OFFSIDES
11	Cetirizine		OFFSIDES
12	Chlorambucil	15656036	CTD
13	Chlorhexidine		OFFSIDES
14	Chlorpropamide		OFFSIDES
15	Citalopram		OFFSIDES
16	Clobazam		OFFSIDES
17	Codeine	17488670	CTD
18	Colchicine	15656036	CTD
19	Cyclophosphamide	15656036	CTD
20	Dapsone		OFFSIDES
21	Dasatinib		OFFSIDES
22	Dextromethorphan	17488670	CTD
23	Dextropropoxyphene		OFFSIDES
24	Dicyclomine		OFFSIDES
25	Diosmin		OFFSIDES
26	Doxepin		OFFSIDES
27	Erythromycin		OFFSIDES
28	Estradiol		OFFSIDES
29	Glipizide		OFFSIDES
30	Homocysteine	10889340	CTD
31	Hydrochlorothiazide		OFFSIDES
32	Lactulose		OFFSIDES
33	Lamotrigine		OFFSIDES
34	Lanthanum carbonate hydrate		OFFSIDES
35	Levetiracetam		OFFSIDES
36	Linezolid		OFFSIDES
37	Lisinopril		OFFSIDES
38	Megestrol		OFFSIDES
39	Megestrol Acetate		OFFSIDES
40	Meloxicam		OFFSIDES
41	Meperidine		OFFSIDES
42	Metformin	View details 7388472 10977010 12583408 17721351 20134380	CTD
43	Methylmalonic Acid	10889340	CTD
44	Metolazone		OFFSIDES
45	Minocycline		OFFSIDES
46	Mitoxantrone		OFFSIDES
47	Modafinil		OFFSIDES
48	Mometasone Furoate		OFFSIDES
49	Mupirocin		OFFSIDES
50	Nabumetone		OFFSIDES
51	Naproxen		OFFSIDES
52	Nateglinide		OFFSIDES
53	Nevirapine		OFFSIDES
54	Nisoldipine		OFFSIDES
55	Nitrous Oxide	6164371	CTD
56	Norfloxacin		OFFSIDES
57	Nortriptyline		OFFSIDES
58	NuvaRing		OFFSIDES
59	Octreotide	2229321	CTD OFFSIDES
60	Palonosetron		OFFSIDES
61	Pamidronate		OFFSIDES
62	Penicillin V		OFFSIDES
63	Pentoxifylline		OFFSIDES
64	Perphenazine		OFFSIDES
65	Phenobarbital	188784 4627864	CTD
66	Phenytoin	188784 4627864	CTD
67	Piroxicam		OFFSIDES
68	Potassium		OFFSIDES
69	Pravastatin		OFFSIDES
70	Primidone	4627864	CTD
71	Prochlorperazine		OFFSIDES
72	Pyridostigmine Bromide		OFFSIDES
73	Risedronic Acid		OFFSIDES
74	Rivastigmine		OFFSIDES
75	Rosiglitazone		OFFSIDES
76	S-Adenosylmethionine	7527320	CTD
77	Saquinavir		OFFSIDES
78	Saridon		OFFSIDES
79	Sulfamethoxazole		OFFSIDES
80	Tadalafil		OFFSIDES
81	Tenofovir		OFFSIDES
82	Tetracycline		OFFSIDES
83	Thiothixene		OFFSIDES
84	Tolterodine Tartrate		OFFSIDES
85	Torsemide		OFFSIDES
86	Tretinoin		OFFSIDES
87	Ubiquinone		OFFSIDES
88	Vincristine		OFFSIDES
89	Vitamin B 12	3948463 13082065	CTD
90	Vitamin E		OFFSIDES
91	Zidovudine		OFFSIDES
92	Zoledronic Acid		OFFSIDES
93	abacavir, lamivudine drug combination		OFFSIDES
94	cefuroxime axetil		OFFSIDES
95	chlorhexidine gluconate		OFFSIDES
96	darifenacin		OFFSIDES
97	efavirenz		OFFSIDES
98	etravirine		OFFSIDES
99	ferrous gluconate		OFFSIDES
100	fexofenadine		OFFSIDES
101	fludarabine		OFFSIDES
102	fosamprenavir		OFFSIDES
103	fosphenytoin		OFFSIDES
104	lamivudine, zidovudine drug combination		OFFSIDES
105	mecobalamin	11979747 20061275	CTD
106	montelukast		OFFSIDES
107	montelukast		OFFSIDES
108	pimecrolimus		OFFSIDES
109	rofecoxib		OFFSIDES
110	tegaserod		OFFSIDES
111	telmisartan, hydrochlorothiazide drug combination		OFFSIDES
112	testosterone 17 beta-cypionate		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Folic Acid Deficiency	49.6%
2	Pellagra	49.6%
3	Thiamine Deficiency	49.6%
4	Vitamin B 6 Deficiency	49.6%
5	Pyridoxine Deficiency	49.6%
6	Beriberi	37.1%
7	Ascorbic Acid Deficiency	36.8%
8	Vitamin A Deficiency	36.8%
9	Vitamin D Deficiency	36.8%
10	Vitamin E Deficiency	36.8%
11	Magnesium Deficiency	29.9%
12	Potassium Deficiency	29.9%
13	Protein Deficiency	29.9%
14	Starvation	25.5%
15	Refeeding Syndrome	25.5%
16	Hyperhomocysteinemia	22.5%
17	Child Nutrition Disorders	21.3%
18	Hypervitaminosis A	21.3%
19	Infant Nutrition Disorders	21.3%
20	Wasting Syndrome	19.4%
21	Vitamin K Deficiency	18.9%
22	Marasmus	17.8%
23	Metabolic Diseases	14.8%
24	Wernicke Encephalopathy	14%
25	Kwashiorkor	13.9%
26	Rickets	13%
27	Scurvy	12.4%
28	Osteomalacia	9%
29	Acid-Base Imbalance	7.1%
30	Calcium Metabolism Disorders	7.1%
31	Iron Metabolism Disorders	7.1%
32	Phosphorus Metabolism Disorders	7.1%
33	Water-Electrolyte Imbalance	7.1%
34	Lipid Metabolism Disorders	7.1%
35	Mitochondrial Diseases	7.1%
36	Glucose Metabolism Disorders	7.1%
37	Renal Osteodystrophy	5.7%
38	Renal rickets	5.7%
39	Hypercalcemia	4.9%
40	Hypocalcemia	4.9%
41	Milk-Alkali Syndrome	4.9%
42	HIV Wasting Syndrome	4.9%
43	Osteopenia	4.8%
44	Brain Diseases, Metabolic	4.7%
45	Obesity	4.3%
46	Lipodystrophy	3.7%
47	Acidosis	3.6%
48	Alkalosis	3.6%
49	Amyloidosis	3.6%
50	Calcinosis	3.6%
51	Hyperglycemia	3.6%
52	Hyperinsulinism	3.6%
53	Hyperkalemia	3.6%
54	Hypernatremia	3.6%
55	Hypoglycemia	3.6%
56	Hypokalemia	3.6%
57	Hyponatremia	3.6%
58	Xanthomatosis	3.6%
59	Hypophosphatemia	3.6%
60	Metabolic acidosis	3.6%
61	Dyslipidemias	3.6%
62	Iron Overload	3.6%
63	Xanthoma	3.6%
64	Familial Hypophosphatemic Rickets	3.5%
65	Pseudohypoparathyroidism	3.1%
66	Obesity, Abdominal	3%
67	Brain Diseases, Metabolic, Inborn	2.9%
68	Diabetes Mellitus	2.6%
69	Dehydration	2.5%
70	Lipomatosis	2.5%
71	Water Intoxication	2.5%
72	Werner Syndrome	2.5%
73	Achlorhydria	2.5%
74	Amino Acid Metabolism, Inborn Errors	2.5%
75	Bloom Syndrome	2.5%
76	Carbohydrate Metabolism, Inborn Errors	2.5%
77	Metal Metabolism, Inborn Errors	2.5%
78	Osteoporosis	2.5%
79	Progeria	2.5%
80	Lysosomal Storage Diseases	2.5%
81	Bone Demineralization, Pathologic	2.5%
82	Cytochrome-c Oxidase Deficiency	2.5%
83	Peroxisomal Disorders	2.5%
84	Post-Traumatic Osteoporosis	2.5%
85	Celiac Disease	2.4%
86	Sprue, Tropical	2.4%
87	Steatorrhea	2.4%
88	Sprue	2.4%
89	Pediatric Obesity	2.4%
90	Lactose Intolerance	2.3%
91	Leigh Disease	2.2%
92	Prader-Willi Syndrome	2%
93	Hypolipoproteinemias	2%
94	Acidosis, Lactic	2%
95	Calciphylaxis	2%
96	Hemosiderosis	2%
97	Ketosis	2%
98	Ketonuria	2%
99	Ketoacidosis	2%
100	Ketonemia	2%
101	Vascular calcification	2%
102	Mitochondrial Encephalomyopathies	1.9%
103	Mitochondrial Myopathies	1.9%
104	Myelinolysis, Central Pontine	1.9%
105	Glycosuria	1.8%
106	Reye Syndrome	1.8%
107	Hepatic Encephalopathy	1.8%
108	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.8%
109	Smith-Lemli-Opitz Syndrome	1.7%
110	Galactosemias	1.7%
111	Urea Cycle Disorders, Inborn	1.7%
112	Tyrosinemias	1.7%
113	Congenital Hyperinsulinism	1.7%
114	Diabetic Ketoacidosis	1.6%
115	Hyperlipidemia, Familial Combined	1.6%
116	Hyperphosphaturia	1.5%
117	Porphyrias, Hepatic	1.5%
118	Necrobiosis Lipoidica Diabeticorum	1.5%
119	Fanconi Anemia	1.5%
120	Hyperlipoproteinemia Type IV	1.4%
121	Hyperlipoproteinemia Type V	1.4%
122	Hyperlipoproteinemia Type III	1.4%
123	Acidosis, Respiratory	1.3%
124	Adiposis Dolorosa	1.3%
125	Alkalosis, Respiratory	1.3%
126	Renal tubular acidosis	1.3%
127	Alkaptonuria	1.3%
128	Glycogen Storage Disease	1.3%
129	Hypophosphatasia	1.3%
130	Insulin Resistance	1.3%
131	Osteoporosis, Postmenopausal	1.3%
132	Propionic acidemia	1.3%
133	Dihydropyrimidine Dehydrogenase Deficiency	1.3%
134	Cystinosis	1.3%
135	Homocystinuria	1.3%
136	Friedreich Ataxia	1.2%
137	Hypoalphalipoproteinemias	1.2%
138	Hypercholesterolemia	1.2%
139	Hyperlipoproteinemias	1.2%
140	Hypertriglyceridemia	1.2%
141	HIV-Associated Lipodystrophy Syndrome	1.2%
142	Zellweger Syndrome	1.1%
143	Amyloid Neuropathies, Familial	1.1%
144	Menkes Kinky Hair Syndrome	1.1%
145	Neuronal Ceroid-Lipofuscinoses	1.1%
146	Kernicterus	1.1%
147	Cockayne Syndrome	1.1%
148	Glycogen storage disease type II	1.1%
149	Gestational Diabetes	1.1%
150	Latent Autoimmune Diabetes in Adults	1.1%
151	MELAS Syndrome	1%
152	Diabetes Mellitus, Experimental	1%
153	Hepatolenticular Degeneration	1%
154	Nephrocalcinosis	1%
155	Tetany	1%
156	Refsum Disease	1%
157	Glycosuria, Renal	1%
158	Cerebral Amyloid Angiopathy	1%
159	Adrenoleukodystrophy	1%
160	Nesidioblastosis	1%
161	Ataxia Telangiectasia	0.9%
162	Optic Atrophy, Hereditary, Leber	0.9%
163	Kearns-Sayre syndrome	0.9%
164	Gaucher Disease	0.9%
165	Xeroderma Pigmentosum	0.8%
166	Familial Periodic Paralysis	0.8%
167	Primary amyloidosis	0.8%
168	Variegate Porphyria	0.8%
169	Acute intermittent porphyria	0.8%
170	Porphyria Cutanea Tarda	0.8%
171	Renal Aminoacidurias	0.8%
172	Fanconi Syndrome	0.8%
173	Pseudohypoaldosteronism	0.8%
174	Liddle Syndrome	0.8%
175	Mucopolysaccharidosis III	0.8%
176	Glycogen Storage Disease Type I	0.8%
177	Glycogen Storage Disease Type V	0.8%
178	Gout	0.7%
179	Amyotrophic Lateral Sclerosis	0.7%
180	Antley-Bixler Syndrome Phenotype	0.7%
181	Fabry Disease	0.7%
182	Sjogren-Larsson Syndrome	0.6%
183	CREST Syndrome	0.6%
184	Niemann-Pick Disease, Type C	0.6%
185	Canavan Disease	0.5%
186	Alexander Disease	0.5%
187	Mucopolysaccharidosis II	0.5%
188	Albinism	0.5%
189	Tay-Sachs Disease	0.5%
190	Hypokalemic periodic paralysis	0.5%
191	Frontotemporal dementia	0.5%
192	Cystinuria	0.5%
193	Ichthyosis, X-Linked	0.4%
194	Arthritis, Gouty	0.4%

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