MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Central Nervous System Infection

(UMLS:C0007684)

Definition:: Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.
UMLS ID:: C0007684
MeSH ID:: D002494

Classification 1:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.395

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.228

Synonym(s)

Central Nervous System Infection

CNS INFECTION

Central Nervous System Infectious Disease

Central Nervous System Infectious Disorder

Central nervous system infection

Central nervous system--Infections

Infectious Disease of Central Nervous System

Infectious disease of central nervous system

central infection nervous system

10.

central infections nervous system

11.

central nervous system infection

12.

central nervous system infections

13.

cns infection

14.

cns infections

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Baclofen	FAERS: 29	US FAERS
2	PCI 32765	FAERS: 6	US FAERS
3	teriflunomide	FAERS: 5	US FAERS
4	Fingolimod Hydrochloride	FAERS: 4 Canada Vigilance: 1	Canada Vigilance US FAERS
5	Bortezomib	FAERS: 3	US FAERS
6	Carmustine	FAERS: 3	US FAERS
7	Dexamethasone	FAERS: 3	US FAERS
8	Glatiramer Acetate	FAERS: 3	US FAERS
9	Imatinib Mesylate	FAERS: 3	US FAERS
10	Iron citrate	FAERS: 3	US FAERS
11	Lenalidomide	FAERS: 3	US FAERS
12	Tacrolimus	FAERS: 3	US FAERS
13	Temozolomide	FAERS: 3 Canada Vigilance: 2	Canada Vigilance US FAERS
14	Aripiprazole	FAERS: 2	US FAERS
15	Atazanavir Sulfate	FAERS: 2	US FAERS
16	Cinacalcet	FAERS: 2	US FAERS
17	Dimethyl Fumarate	FAERS: 2	US FAERS
18	Isotretinoin	FAERS: 2	US FAERS
19	Levetiracetam	FAERS: 2	OFFSIDES US FAERS
20	Zoledronic Acid	FAERS: 2	US FAERS
21	1 alpha-hydroxyergocalciferol	FAERS: 1	US FAERS
22	4-Aminopyridine	FAERS: 1	US FAERS
23	4-hydroxybutyric acid	FAERS: 1	US FAERS
24	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1	US FAERS
25	Alendronate	FAERS: 1	US FAERS
26	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination	FAERS: 1	US FAERS
27	Azacitidine	FAERS: 1	US FAERS
28	Bendamustine Hydrochloride	FAERS: 1	US FAERS
29	Bosentan	FAERS: 1	US FAERS
30	Ciprodex	FAERS: 1	US FAERS
31	Clofarabine	FAERS: 1	OFFSIDES US FAERS
32	Clozapine	FAERS: 1	US FAERS
33	Cyclosporine	FAERS: 1	US FAERS
34	Dabigatran	FAERS: 1	US FAERS
35	Dasatinib	FAERS: 1	US FAERS
36	Deferasirox	FAERS: 1	US FAERS
37	Didanosine	FAERS: 1	US FAERS
38	Duloxetine Hydrochloride	FAERS: 1	US FAERS
39	Ertapenem	FAERS: 1	US FAERS
40	Fluconazole	FAERS: 1	US FAERS
41	Fluticasone	FAERS: 1	US FAERS
42	Gabapentin	FAERS: 1	US FAERS
43	Haloperidol	FAERS: 1	US FAERS
44	Insulin Glargine	FAERS: 1	US FAERS
45	Itraconazole	FAERS: 1	US FAERS
46	Lamotrigine	FAERS: 1	US FAERS
47	Linezolid	FAERS: 1	US FAERS
48	Metformin	FAERS: 1	US FAERS
49	Methotrexate	FAERS: 1	US FAERS
50	Methylprednisolone	FAERS: 1	US FAERS
51	NuvaRing	FAERS: 1	US FAERS
52	Oseltamivir	FAERS: 1	US FAERS
53	Rivaroxaban	FAERS: 1	US FAERS
54	Sunitinib	FAERS: 1	US FAERS
55	Teriparatide	FAERS: 1	US FAERS
56	Valsartan	FAERS: 1	US FAERS
57	Viekira Pak	FAERS: 1	US FAERS
58	ambrisentan	FAERS: 1	US FAERS
59	apremilast	FAERS: 1	US FAERS
60	eltrombopag	FAERS: 1	US FAERS
61	fludarabine phosphate	FAERS: 1	OFFSIDES US FAERS
62	iopromide	FAERS: 1	US FAERS
63	liposomal amphotericin B	FAERS: 1	US FAERS
64	pomalidomide	FAERS: 1	US FAERS
65	posaconazole	FAERS: 1	US FAERS
66	zafirlukast	FAERS: 1	US FAERS
67	Acyclovir		OFFSIDES
68	Ascorbic Acid		OFFSIDES
69	Capsaicin		OFFSIDES
70	Cefepime		OFFSIDES
71	Ceftriaxone		OFFSIDES
72	Cephalexin		OFFSIDES
73	Cyproheptadine		OFFSIDES
74	Cytarabine		OFFSIDES
75	Etoposide		OFFSIDES
76	Felbamate		OFFSIDES
77	Hydrocortisone sodium succinate		OFFSIDES
78	Idarubicin		OFFSIDES
79	Meropenem		SIDER
80	Morphine		OFFSIDES
81	Piperacillin, Tazobactam Drug Combination		OFFSIDES
82	Thioridazine		OFFSIDES
83	Tiotropium Bromide		OFFSIDES
84	Vancomycin		OFFSIDES
85	Vitamin K 1		OFFSIDES
86	Voriconazole		OFFSIDES
87	clindamycin phosphate		OFFSIDES
88	proxigermanium		SIDER
89	ropinirole		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Brain Diseases	30%
2	Meningitis	30%
3	Movement Disorders	30%
4	Pachymeningitis	30%
5	Spinal Cord Diseases	30%
6	Parkinsonian Disorders	29.2%
7	Multiple System Atrophy	27.5%
8	Meige Syndrome	26.3%
9	Parkinson Disease	25.6%
10	Pneumocephalus	25.4%
11	Lewy Body Disease	25.3%
12	Posterior Leukoencephalopathy Syndrome	24.9%
13	Posterior reversible encephalopathy syndrome	24.9%
14	Ocular Motility Disorders	24.2%
15	Cyclophoria	24.2%
16	Myoclonic Epilepsy	23.5%
17	Epilepsy, Temporal Lobe	23.5%
18	Epilepsy, Rolandic	23.5%
19	Benign Rolandic Epilepsy	23.5%
20	Striatonigral Degeneration	22.5%
21	Dandy-Walker Syndrome	22.1%
22	Juvenile Myoclonic Epilepsy	22.1%
23	Myoclonic Epilepsies, Progressive	22.1%
24	Akinetic Mutism	22%
25	Anoxic Encephalopathy	22%
26	Arachnoiditis	22%
27	Basal Ganglia Diseases	22%
28	Brain Damage, Chronic	22%
29	Cerebellar Diseases	22%
30	Encephalitis	22%
31	Encephalomalacia	22%
32	Epilepsy	22%
33	Hydrocephalus	22%
34	Congenital Hydrocephalus	22%
35	Hypothalamic Diseases	22%
36	Aseptic Meningitis	22%
37	Syringomyelia	22%
38	Thalamic Diseases	22%
39	Intracranial Hypertension	22%
40	Aura	22%
41	Leukoencephalopathy	22%
42	Essential Tremor	22%
43	Neuroaxonal Dystrophies	22%
44	Familial Tremor	22%
45	Headache Disorders	22%
46	Intracranial Hypotension	22%
47	Brain Edema	22%
48	Brain Hypoxia	22%
49	Aqueductal Stenosis	22%
50	Pneumorrhachis	22%
51	Writer's Cramp	22%
52	Encephalomyelitis	21.8%
53	Dementia, Vascular	21.4%
54	Spinal Muscular Atrophy	21.1%
55	Progressive Muscular Atrophy	21.1%
56	Bacterial Infections	21.1%
57	Mycoses	21.1%
58	Infection	21.1%
59	Basal Ganglia Cerebrovascular Disease	20.8%
60	Marchiafava-Bignami Disease	20.7%
61	Dystonia Musculorum Deformans	20.7%
62	Stiff-Person Syndrome	20.2%
63	Epilepsy, Post-Traumatic	19.9%
64	MPTP Poisoning	19.8%
65	Vascular Headaches	19.7%
66	Hypoxia-Ischemia, Brain	19.6%
67	Meningitis, Bacterial	19.6%
68	Meningitis, Fungal	19.6%
69	Spinal Cord Injuries	19.4%
70	Meningitis, Cryptococcal	19.4%
71	Shy-Drager Syndrome	19.2%
72	Meningoencephalitis	19%
73	Meningitis, Listeria	18.7%
74	Huntington Disease	18.6%
75	Lyme Disease	18.6%
76	Relapsing Fever	18.6%
77	Asterixis	18.6%
78	Ballismus	18.6%
79	Cerebellar Neoplasms	18.6%
80	Progressive supranuclear palsy	18.4%
81	Meningitis, Haemophilus	18.4%
82	Meningitis, Pneumococcal	18.4%
83	Cerebral Palsy	18.1%
84	Epilepsies, Partial	18.1%
85	Epilepsy, Generalized	18.1%
86	Pseudotumor Cerebri	18.1%
87	Hypertensive Encephalopathy	18.1%
88	Simple Partial Seizures	18.1%
89	Epilepsy, Reflex	18.1%
90	Headache Disorders, Primary	18.1%
91	Headache Disorders, Secondary	18.1%
92	Medication overuse headache	18.1%
93	Borrelia Infections	17.9%
94	Leptospirosis	17.9%
95	Amyotrophic Lateral Sclerosis	17.7%
96	Lafora Disease	17.5%
97	Unverricht-Lundborg Syndrome	17.5%
98	Mycetoma	17.4%
99	Candidemia	17.3%
100	Leukomalacia, Periventricular	17.2%
101	Lyme Neuroborreliosis	17.1%
102	Subacute Combined Degeneration	17%
103	Brain Injuries	16.9%
104	Impetigo	16.8%
105	Brain Neoplasms	16.8%
106	Spinal Cord Neoplasms	16.8%
107	Candidiasis, Chronic Mucocutaneous	16.7%
108	Cutaneous Candidiasis	16.7%
109	Erythema Chronicum Migrans	16.6%
110	Basal Ganglia Hemorrhage	16.5%
111	Brain Diseases, Metabolic	16.4%
112	Cerebrovascular Disorders	16.4%
113	Cerebrovascular Insufficiency	16.4%
114	Dementia	16.4%
115	Conus Medullaris Syndrome	16.4%
116	Spinal Cord Vascular Diseases	16.4%
117	Neuroleptic Malignant Syndrome	16.3%
118	Myelinolysis, Central Pontine	16.3%
119	Friedreich Ataxia	16.2%
120	Post-Traumatic Headache	16.2%
121	Tension Headache	16.2%
122	Epilepsy, Complex Partial	16.2%
123	Migraine Disorders	16.2%
124	Abdominal Migraine	16.2%
125	Status Migrainosus	16.2%
126	Cervicogenic Headache	16.2%
127	Leukoencephalitis, Acute Hemorrhagic	16.1%
128	Myelitis	16.1%
129	Chronic Fatigue Syndrome	16%
130	Erysipelas	16%
131	Staphylococcal Skin Infections	16%
132	Subdural Effusion	15.9%
133	Brain Abscess	15.8%
134	Cranial nerve diseases	15.8%
135	Demyelinating Diseases	15.8%
136	Demyelination	15.8%
137	Neuromuscular Diseases	15.8%
138	Chronobiology Disorders	15.8%
139	Human Ehrlichiosis	15.8%
140	Dermatomycoses	15.7%
141	Skin Diseases, Bacterial	15.7%
142	Erythrasma	15.7%
143	Putaminal Hemorrhage	15.6%
144	Syphilis	15.6%
145	Bacteremia	15.5%
146	Pituitary Apoplexy	15.5%
147	Epidural Abscess	15.5%
148	Brain Death	15.5%
149	Infarction, Middle Cerebral Artery	15.5%
150	Infarction, Anterior Cerebral Artery	15.5%
151	Infarction, Posterior Cerebral Artery	15.5%
152	Tuberculosis, Meningeal	15.4%
153	Neurosyphilis	15.3%
154	Japanese Spotted Fever	15.3%
155	Brain Infarction	15.3%
156	Cluster Headache	15.2%
157	Migraine with Aura	15.2%
158	Familial Hemiplegic Migraine	15.2%
159	Chronic Paroxysmal Hemicrania	15.2%
160	SUNCT Syndrome	15.2%
161	Paroxysmal Hemicrania	15.2%
162	Aspergillosis	15%
163	Candidiasis	15%
164	Coccidioidomycosis	15%
165	Histoplasmosis	15%
166	Paracoccidioidomycosis	15%
167	Pelvic Infection	15%
168	Wound Infection	15%
169	Zygomycosis	15%
170	Gram-Negative Bacterial Infections	15%
171	Gram-Positive Bacterial Infections	15%
172	Soft Tissue Infection	15%
173	Community-Acquired Infections	15%
174	Phaeohyphomycosis	15%
175	Pneumocystis Infections	15%
176	Central Cord Syndrome	14.9%
177	Pituitary Adenoma	14.8%
178	Pituitary Neoplasms	14.8%
179	Motor Neuron Disease	14.8%
180	Ophthalmoplegic Migraine	14.7%
181	Presenile dementia	14.7%
182	Senile dementia	14.7%
183	Staphylococcal Scalded Skin Syndrome	14.6%
184	Encephalomyelitis, Acute Disseminated	14.6%
185	Chorea	14.6%
186	Rocky Mountain Spotted Fever	14.5%
187	Ulcerative stomatitis	14.3%
188	Cerebral Infarction	14.3%
189	Brain Stem Infarctions	14.3%
190	Hidradenitis Suppurativa	14.1%
191	Pituitary Diseases	14%
192	carbuncle	14%
193	Neuroaspergillosis	14%
194	Brain Hemorrhage, Traumatic	14%
195	Fungemia	13.9%
196	Carotid Artery Injuries	13.9%
197	Lateral Medullary Syndrome	13.8%
198	Brain Injuries, Diffuse	13.8%
199	Traumatic Brain Injury	13.8%
200	Cerebellar Ataxia	13.7%
201	Supratentorial Neoplasms	13.7%
202	Torticollis	13.7%
203	Ecthyma	13.7%
204	Subacute Bacterial Endocarditis	13.7%
205	Chlamydia Infections	13.6%
206	Gonorrhea	13.6%
207	Hepatolenticular Degeneration	13.5%
208	Miller Fisher Syndrome	13.5%
209	Pertussis	13.5%
210	Botulism	13.5%
211	Opsoclonus-Myoclonus Syndrome	13.4%
212	Amblyopia	13.3%
213	Persistent Vegetative State	13.3%
214	Poliomyelitis	13.3%
215	Carotid Artery Diseases	13.3%
216	Brain Ischemia	13.3%
217	Cerebrovascular accident	13.3%
218	Kluver-Bucy Syndrome	13.3%
219	Vasospasm, Intracranial	13.3%
220	Spinal Cord Ischemia	13.3%
221	Intracranial Arterial Diseases	13.3%
222	Chromoblastomycosis	13.2%
223	Dermatophytosis	13.2%
224	Sporotrichosis	13.2%
225	Tinea	13.2%
226	Tinea Versicolor	13.2%
227	Trichophytosis	13.2%
228	Invasive Pulmonary Aspergillosis	13.2%
229	Hyalohyphomycosis	13.2%
230	Cerebral Ventriculitis	13.2%
231	Endotoxemia	13.1%
232	Bacterial Endocarditis	13.1%
233	Human anaplasmosis	13%
234	Akathisia, Drug-Induced	13%
235	Panophthalmitis	13%
236	Canavan Disease	12.8%
237	Alexander Disease	12.8%
238	Autonomic Dysreflexia	12.7%
239	Complex Regional Pain Syndromes	12.7%
240	Joint Tuberculosis	12.7%
241	Tuberculosis, Osteoarticular	12.7%
242	Bone Tuberculosis	12.7%
243	Tardive Dyskinesia	12.7%
244	Furunculosis	12.7%
245	furuncle	12.7%
246	Moyamoya Disease	12.6%
247	Dyskinesia, Drug-Induced	12.6%
248	Polyradiculoneuropathy	12.4%
249	Polyradiculoneuritis	12.4%
250	Lymphogranuloma Venereum	12.4%
251	Blastomycosis	12.4%
252	Diffuse Axonal Injury	12.3%
253	Brain Stem Neoplasms	12.3%
254	Lupus Vasculitis, Central Nervous System	12.3%
255	Actinomycetales Infections	12.2%
256	Bordetella Infections	12.2%
257	Brucellosis	12.2%
258	Campylobacter infection	12.2%
259	Clostridium Infections	12.2%
260	Enterobacteriaceae Infections	12.2%
261	Listeriosis	12.2%
262	Mucormycosis	12.2%
263	Pseudomonas Infections	12.2%
264	Q Fever	12.2%
265	Staphylococcal Infections	12.2%
266	Streptococcal Infections	12.2%
267	Vibrio Infections	12.2%
268	Helicobacter Infections	12.2%
269	Bacillaceae Infections	12.2%
270	Neisseriaceae Infections	12.2%
271	Burkholderia Infections	12.2%
272	Clostridium difficile infection	12.2%
273	Flavobacteriaceae Infections	12.2%
274	Moraxellaceae Infections	12.2%
275	Burkholderia cepacia Infection	12.2%
276	Empty Sella Syndrome	12.1%
277	Hyperpituitarism	12.1%
278	Hypopituitarism	12.1%
279	Hypophysitis	12.1%
280	Paraneoplastic Cerebellar Degeneration	12.1%
281	Trauma, Nervous System	12%
282	Fusariosis	12%
283	Syphilis, Congenital	11.9%
284	Cerebral Arterial Diseases	11.8%
285	Vertebrobasilar Insufficiency	11.8%
286	Anterior Spinal Artery Syndrome	11.8%
287	Basilar Artery Stenosis	11.8%
288	Vertebral Artery Stenosis	11.8%
289	Intracranial Hemorrhage, Hypertensive	11.8%
290	Transient Cerebral Ischemia	11.8%
291	Cellulitis	11.7%
292	Restless Legs Syndrome	11.6%
293	Eye Infection	11.5%
294	Nervous System Neoplasms	11.5%
295	Neurologic Manifestations	11.5%
296	Respiratory Tract Infections	11.5%
297	Neurotoxicity Syndromes	11.5%
298	Choroid Plexus Papilloma	11.5%
299	Vasculitis, Central Nervous System	11.4%
300	Subarachnoid Hemorrhage, Traumatic	11.2%
301	Carotid Artery, Internal, Dissection	11.2%
302	Hyperprolactinemia	11.2%
303	Myelitis, Transverse	11.1%
304	Bone Diseases, Infectious	11.1%
305	Causalgia	11.1%
306	Hordeolum	11.1%
307	Leukoencephalopathy, Progressive Multifocal	11.1%
308	Otomycosis	11.1%
309	Pregnancy Complications, Infectious	11.1%
310	Skin Diseases, Infectious	11.1%
311	Subclavian Steal Syndrome	11.1%
312	Pick Disease of the Brain	11.1%
313	Ophthalmia Neonatorum	11%
314	Trachoma	11%
315	Guillain-Barre Syndrome	11%
316	Bacterial conjunctivitis	11%
317	Arthritis, Infectious	10.9%
318	Piedra	10.9%
319	Amnesia, Transient Global	10.9%
320	Central Nervous System Fungal Infections	10.9%
321	Suppuration	10.9%
322	Acinetobacter Infections	10.8%
323	Actinomycosis	10.8%
324	Bacteroides Infections	10.8%
325	Cholera	10.8%
326	Corynebacterium Infections	10.8%
327	Escherichia coli Infections	10.8%
328	Gas Gangrene	10.8%
329	Haemophilus Infections	10.8%
330	Klebsiella Infections	10.8%
331	Meningococcal Infections	10.8%
332	Mycobacterium Infections	10.8%
333	Mycoplasma Infections	10.8%
334	Nocardia Infections	10.8%
335	Pasteurella Infections	10.8%
336	Pneumococcal Infections	10.8%
337	Proteus Infections	10.8%
338	Rickettsia Infections	10.8%
339	Salmonella infections	10.8%
340	Scarlet Fever	10.8%
341	Scrub Typhus	10.8%
342	Tetanus	10.8%
343	Psoas Abscess	10.8%
344	Serratia Infections	10.8%
345	Ureaplasma Infections	10.8%
346	Abdominal Abscess	10.8%
347	Pulmonary Nocardiosis	10.8%
348	Cross Infection	10.8%
349	Septicemia	10.8%
350	Sepsis	10.8%
351	Bacterial Vaginosis	10.8%
352	Progressive bulbar palsy	10.7%
353	Bulbar palsy	10.7%
354	Rhinoscleroma	10.6%
355	Reye Syndrome	10.5%
356	Pyomyositis	10.5%
357	Frontotemporal dementia	10.5%
358	Intracranial Embolism and Thrombosis	10.4%
359	Hepatic Encephalopathy	10.4%
360	Creutzfeldt-Jakob disease	10.4%
361	Limbic Encephalitis	10.2%
362	Brain Contusion	10.2%
363	Diphtheria	10.2%
364	Leprosy	10.2%
365	Mycobacterium Infections, Nontuberculous	10.2%
366	Psittacosis	10.2%
367	Paratyphoid Fever	10.2%
368	Plague	10.2%
369	Tuberculosis	10.2%
370	Typhoid Fever	10.2%
371	TYPHUS	10.2%
372	Yersinia pseudotuberculosis Infections	10.2%
373	Bubonic Plague	10.2%
374	Mycobacterium abscessus Infection	10.2%
375	Peripheral Nerve Injuries	10.1%
376	Dysautonomia	10%
377	Myasthenia Gravis	10%
378	Vagus Nerve Disorder	10%
379	Glossopharyngeal Neuralgia	10%
380	Abducens Nerve Diseases	10%
381	Heavy Metal Poisoning, Nervous System	10%
382	Neuromuscular Junction Diseases	10%
383	Tauopathies	10%
384	Trochlear Nerve Diseases	10%
385	Peripheral Nervous System Diseases	10%
386	Tinea Capitis	9.9%
387	Onychomycosis	9.9%
388	Mycobacterium avium-intracellulare Infection	9.9%
389	Lymph Node Tuberculosis	9.9%
390	Tuberculosis, Miliary	9.9%
391	Tuberculosis, Multidrug-Resistant	9.9%
392	Leprosy, Multibacillary	9.9%
393	Latent Tuberculosis	9.9%
394	Olfactory Nerve Injuries	9.8%
395	Mitochondrial Encephalomyopathies	9.8%
396	Reflex Sympathetic Dystrophy	9.7%
397	Nocturnal Myoclonus Syndrome	9.7%
398	Borderline leprosy	9.7%
399	Leprosy, Lepromatous	9.7%
400	Tuberculoid leprosy	9.7%
401	Extensively Drug-Resistant Tuberculosis	9.7%
402	Tuberculosis, Spinal	9.7%
403	Brain Concussion	9.6%
404	Ataxia Telangiectasia	9.6%
405	Erythema Induratum	9.6%
406	Alice in Wonderland Syndrome	9.5%
407	Vertebral Artery Dissection	9.5%
408	MELAS Syndrome	9.5%
409	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	9.5%
410	Erysipelothrix infection	9.4%
411	Opportunistic Infections	9.4%
412	Carotid Stenosis	9.3%
413	Intracranial Aneurysm	9.3%
414	Intracranial Arteriosclerosis	9.3%
415	Cerebral Atherosclerosis	9.3%
416	Subarachnoid Hemorrhage	9.3%
417	Cerebral Arteriosclerosis	9.3%
418	Cerebral Hemorrhage	9.3%
419	Cerebral Thrombosis	9.2%
420	Intracranial Embolism	9.2%
421	Intracranial Thrombosis	9.2%
422	Sleep Wake Disorders	9.2%
423	Adrenoleukodystrophy	9.1%
424	Waterhouse-Friderichsen Syndrome	9.1%
425	Oral candidiasis	9.1%
426	Endophthalmitis	9.1%
427	Peritonitis	9.1%
428	Neuromyelitis Optica	9.1%
429	Osteomyelitis	8.9%
430	Periostitis	8.9%
431	Surgical Wound Infection	8.9%
432	Pulmonary Aspergillosis	8.9%
433	Bronchopulmonary Aspergillosis	8.9%
434	Acromegaly	8.9%
435	Abscess	8.8%
436	Adnexitis	8.8%
437	Empyema	8.8%
438	Pelvic Inflammatory Disease	8.8%
439	Lung Diseases, Fungal	8.8%
440	Brachial Plexus Neuritis	8.8%
441	Neuralgic Amyotrophy	8.8%
442	Toxoplasmosis, Cerebral	8.8%
443	Cerebral Amyloid Angiopathy	8.7%
444	Urinary tract infection	8.7%
445	Central Nervous System Bacterial Infections	8.7%
446	Sinus Thrombosis, Intracranial	8.7%
447	Brain Diseases, Metabolic, Inborn	8.7%
448	Lambert-Eaton Myasthenic Syndrome	8.7%
449	Pneumonia, Bacterial	8.6%
450	Sleep Disorders, Circadian Rhythm	8.5%
451	Auditory Perceptual Disorders	8.5%
452	Tinea Pedis	8.4%
453	Multiple Sclerosis	8.4%
454	Cavernous Sinus Thrombosis	8.4%
455	Sagittal Sinus Thrombosis	8.4%
456	Facial Nerve Injuries	8.3%
457	Tarsal Tunnel Syndrome	8.3%
458	Cauda Equina Syndrome	8.3%
459	Central Nervous System Cysts	8.2%
460	Salmonella Infections, Animal	7.9%
461	Diverticulitis	7.9%
462	Myopathy	7.7%
463	Optic Neuropathy	7.7%
464	Carotid Artery Thrombosis	7.6%
465	Liver Abscess	7.6%
466	Rheumatic Heart Disease	7.6%
467	Acrodynia	7.6%
468	Horner Syndrome	7.5%
469	Charcot-Marie-Tooth Disease	7.5%
470	Salmonella food poisoning	7.5%
471	Hematoma, Subdural	7.4%
472	Hematoma, Epidural, Cranial	7.4%
473	Facial Nerve Diseases	7.4%
474	Craniocerebral Trauma	7.4%
475	Parasomnia	7.4%
476	Sexually Transmitted Diseases	7.4%
477	Dyssomnias	7.4%
478	Tuberculosis, Gastrointestinal	7.4%
479	Refsum Disease	7.4%
480	Wernicke Encephalopathy	7.3%
481	Neuritis	7.3%
482	Polyneuritis	7.3%
483	Radiculitis	7.3%
484	Polyneuropathy	7.3%
485	Mononeuritis	7.3%
486	Mononeuropathies	7.3%
487	Brachial Plexus Neuropathies	7.3%
488	Radiculopathy	7.3%
489	Mononeuropathy Multiplex	7.3%
490	Nerve Root Compression	7.3%
491	AIDS Dementia Complex	7.3%
492	Giant Cell Arteritis	7.3%
493	Temporal Arteritis	7.3%
494	Vestibulocochlear Nerve Diseases	7.3%
495	Decerebrate State	7.3%
496	Hemiparesis	7.3%
497	Hydranencephaly	7.3%
498	Meningism	7.3%
499	Neural Tube Defects	7.3%
500	Paresis	7.3%
501	Seizures	7.3%
502	Sensation Disorders	7.3%
503	Tethered Cord Syndrome	7.3%
504	Central Nervous System Neoplasms	7.3%
505	Complex partial seizures	7.3%
506	Iniencephaly	7.3%
507	Craniorachischisis	7.3%
508	Prion Diseases	7.3%
509	Exencephaly	7.3%
510	Monoparesis	7.3%
511	Septo-Optic Dysplasia	7.3%
512	Cortical Dysplasia	7.3%
513	Neurogenic Inflammation	7.3%
514	Gait Disorders, Neurologic	7.3%
515	Neuromuscular Manifestations	7.3%
516	Malformations of Cortical Development	7.3%
517	Superinfection	7.2%
518	Sweating, Gustatory	7.2%
519	Auriculotemporal Syndrome	7.2%
520	Myasthenia Gravis, Autoimmune, Experimental	7.2%
521	Tuberculosis, Central Nervous System	7.2%
522	Corneal Ulcer	7.1%
523	Coma, Post-Head Injury	7.1%
524	Puerperal Infection	7%
525	Spondylitis	7%
526	Ophthalmoplegia	7%
527	External Ophthalmoplegia	7%
528	Appendicitis	7%
529	Bacteriuria	7%
530	Pyuria	7%
531	Hematoma, Subdural, Intracranial	7%
532	Hematoma, Subdural, Chronic	7%
533	Hematoma, Subdural, Acute	7%
534	Nelson Syndrome	7%
535	Endotoxic shock	6.9%
536	Septic Shock	6.9%
537	Toxic Shock Syndrome	6.9%
538	Multiple Sclerosis, Chronic Progressive	6.9%
539	Candidiasis, Vulvovaginal	6.9%
540	Multiple Sclerosis, Relapsing-Remitting	6.9%
541	Carpal Tunnel Syndrome	6.6%
542	neurofibroma	6.5%
543	Sciatica	6.5%
544	Kernicterus	6.5%
545	Lung Abscess	6.5%
546	Jet Lag Syndrome	6.4%
547	Rheumatic Fever	6.4%
548	Myotonia Congenita	6.4%
549	Diverticulum	6.3%
550	Diverticulosis	6.3%
551	Cerebrospinal Fluid Otorrhea	6.3%
552	Cerebrospinal Fluid Rhinorrhea	6.3%
553	Neuritis, Autoimmune, Experimental	6.3%
554	Gait Ataxia	6.3%
555	Discitis	6.2%
556	Enterocolitis, Pseudomembranous	6.2%
557	Mastoiditis	6.2%
558	Petrositis	6.2%
559	pseudomembranous colitis	6.2%
560	Dysentery, Bacillary	6.2%
561	Prolactinoma	6.2%
562	Growth Hormone-Secreting Pituitary Adenoma	6.2%
563	Cubital Tunnel Syndrome	6.2%
564	Vocal Cord Paralysis	6%
565	Sciatic Neuropathy	6%
566	Ulnar Neuropathies	6%
567	Lesion of Sciatic Nerve	6%
568	Ulnar Neuritis	6%
569	Radial nerve compression	6%
570	Radial Tunnel Syndrome	6%
571	Peroneal Neuropathies	6%
572	Radial Neuropathy	6%
573	Median Neuropathy	6%
574	Sciatic Nerve Palsy	6%
575	Femoral Neuropathy	6%
576	Tibial Neuropathy	6%
577	Ulnar Nerve Palsy	6%
578	Postural Orthostatic Tachycardia Syndrome	6%
579	Radial nerve palsy	6%
580	Fabry Disease	6%
581	Tuberous Sclerosis	6%
582	Pupil Disorders	6%
583	Neurobehavioral Manifestations	6%
584	Tuberculosis, Pulmonary	5.9%
585	Myotonic Dystrophy	5.8%
586	Paraneoplastic Encephalomyelitis	5.8%
587	Uveomeningoencephalitic Syndrome	5.7%
588	Sturge-Weber Syndrome	5.7%
589	Vertigo	5.7%
590	Arthritis, Reactive	5.7%
591	Alcohol-Induced Disorders, Nervous System	5.7%
592	Galactosemias	5.7%
593	Urea Cycle Disorders, Inborn	5.7%
594	Tyrosinemias	5.7%
595	Myositis	5.5%
596	Optic Atrophy	5.5%
597	Optic Neuritis	5.5%
598	Papilledema	5.5%
599	Strabismus	5.5%
600	Tolosa-Hunt Syndrome	5.5%
601	Isaacs syndrome	5.5%
602	Arsenic Poisoning	5.5%
603	Myotonic Disorders	5.5%
604	Myasthenic Syndromes, Congenital	5.5%
605	Polyradiculopathy	5.4%
606	Diabetic Neuropathies	5.4%
607	Facial Injuries	5.4%
608	Facial Neuralgia	5.4%
609	Diabetic Amyotrophy	5.4%
610	Diabetic Autonomic Neuropathy	5.4%
611	Sleep Talking	5.4%
612	Manganese Poisoning	5.4%
613	Sleep Disorders, Intrinsic	5.4%
614	Orthostatic intolerance	5.4%
615	Akathisia	5.4%
616	Restlessness	5.4%
617	Psychomotor Agitation	5.4%
618	Optic Nerve Glioma	5.3%
619	Anosmia	5.3%
620	Ataxia	5.3%
621	Athetosis	5.3%
622	Catalepsy	5.3%
623	Dystonia	5.3%
624	Hemiplegia	5.3%
625	Locked-In Syndrome	5.3%
626	Meningeal Neoplasms	5.3%
627	Meningomyelocele	5.3%
628	Muscle Hypertonia	5.3%
629	Muscle hypotonia	5.3%
630	Myoclonus	5.3%
631	Myotonia	5.3%
632	Neuralgia	5.3%
633	Paraplegia	5.3%
634	Pseudobulbar Palsy	5.3%
635	Quadriplegia	5.3%
636	Spasm	5.3%
637	Spastic Paraplegia	5.3%
638	Status Epilepticus	5.3%
639	Taste Disorders	5.3%
640	Tremor	5.3%
641	Spina Bifida	5.3%
642	Monoplegia	5.3%
643	Hypokinesia	5.3%
644	Paraparesis	5.3%
645	Bradykinesia	5.3%
646	Waxy flexibility	5.3%
647	Action Tremor	5.3%
648	Resting Tremor	5.3%
649	Dysosmia	5.3%
650	Quadriparesis	5.3%
651	Mercury Poisoning, Nervous System	5.3%
652	Olfaction Disorders	5.3%
653	Myokymia	5.3%
654	Lead Poisoning, Nervous System	5.3%
655	Vestibular Neuronitis	5.3%
656	Somatosensory Disorders	5.3%
657	Neuropathic pain	5.3%
658	Hyperkinesia	5.3%
659	Intention tremor	5.3%
660	Retropharyngeal Abscess	5.2%
661	Peritonsillar Abscess	5.1%
662	Alcohol Withdrawal Seizures	5.1%
663	Gait Apraxia	5.1%
664	Homocystinuria	5%
665	AIDS-Related Opportunistic Infections	5%
666	Leigh Disease	5%
667	Menkes Kinky Hair Syndrome	5%
668	Subacute Sclerosing Panencephalitis	4.8%
669	Voice Disorders	4.8%
670	Voice Disturbance	4.8%
671	Alstrom Syndrome	4.7%
672	Smith-Magenis syndrome	4.7%
673	Carbamoyl-Phosphate Synthase I Deficiency Disease	4.7%
674	Dural Arteriovenous Fistula	4.7%
675	Classical Lissencephalies and Subcortical Band Heterotopias	4.6%
676	Thoracic Outlet Syndrome	4.5%
677	Hand-Arm Vibration Syndrome	4.5%
678	Aspergillosis, Allergic Bronchopulmonary	4.4%
679	Esotropia	4.4%
680	Exotropia	4.4%
681	Hypotension, Orthostatic	4.4%
682	Sleep Apnea Syndromes	4.4%
683	Polymyositis	4.4%
684	Post-Exercise Hypotension	4.4%
685	Disorders of Excessive Somnolence	4.4%
686	Sleep Initiation and Maintenance Disorders	4.4%
687	Night Terrors	4.4%
688	Somnambulism	4.4%
689	Trigeminal Nerve Disorder	4.4%
690	Transient Insomnia	4.4%
691	Sleep Paralysis	4.4%
692	Chronic Insomnia	4.4%
693	REM Sleep Behavior Disorder	4.4%
694	Hypersomnia	4.4%
695	Vision Disorders	4.4%
696	Metamorphopsia	4.4%
697	Visual Impairment	4.4%
698	Dermal Sinus	4.4%
699	Dysgeusia	4.4%
700	Formication	4.4%
701	Hyperalgesia	4.4%
702	Hyperesthesia	4.4%
703	Hypesthesia	4.4%
704	Language Disorders	4.4%
705	Numbness	4.4%
706	Paresthesia	4.4%
707	Paraparesis, Spastic	4.4%
708	Spina Bifida Cystica	4.4%
709	Trismus	4.4%
710	Spina Bifida Occulta	4.4%
711	Epilepsia Partialis Continua	4.4%
712	Hypogeusia	4.4%
713	Meningeal Carcinomatosis	4.4%
714	Brown-Sequard Syndrome	4.4%
715	Lissencephaly	4.4%
716	Polymicrogyria	4.4%
717	Pachygyria	4.4%
718	Schizencephaly	4.4%
719	Lockjaw	4.4%
720	Allodynia	4.4%
721	Lead Poisoning, Nervous System, Childhood	4.4%
722	Lead Poisoning, Nervous System, Adult	4.4%
723	Periventricular Nodular Heterotopia	4.4%
724	Ageusia	4.4%
725	Fibromyalgia	4.3%
726	Optic Neuropathy, Ischemic	4.3%
727	Anterior Ischemic Optic Neuropathy	4.3%
728	Medial Tibial Stress Syndrome	4.3%
729	Alexia	4.3%
730	Dyslexia	4.3%
731	Facial Hemiatrophy	4.3%
732	Melkersson-Rosenthal Syndrome	4.3%
733	Mitochondrial Myopathies	4.3%
734	Anisocoria	4.3%
735	Confusion	4.3%
736	Facial paralysis	4.3%
737	Lethargy	4.3%
738	Memory Disorders	4.3%
739	Muscle Cramp	4.3%
740	Perceptual Disorders	4.3%
741	Psychomotor Disorders	4.3%
742	Scrapie	4.3%
743	Tonic Pupil	4.3%
744	Eosinophilia-Myalgia Syndrome	4.3%
745	Anhedonia	4.3%
746	Disorientation	4.3%
747	Facial Paresis	4.3%
748	Memory Loss	4.3%
749	Hemisensory Neglect	4.3%
750	Dysacusis	4.3%
751	Sleep Bruxism	4.2%
752	Anencephaly	4.2%
753	Meningocele	4.2%
754	Muscular Atrophy	4.2%
755	Respiratory Paralysis	4.2%
756	Encephalocele	4.2%
757	Glycogen storage disease type II	4.2%
758	Tetany	4.2%
759	Neurofibrosarcoma	4.2%
760	West Nile Fever	4.1%
761	Amyloid Neuropathies, Familial	4.1%
762	Liver Abscess, Amebic	4.1%
763	Tuberculosis, Renal	4%
764	Reflex, Abnormal	3.9%
765	Hyporeflexia	3.9%
766	Hyperreflexia	3.9%
767	Sleep Apnea, Obstructive	3.9%
768	Sleep Apnea, Central	3.9%
769	Narcolepsy	3.9%
770	Trigeminal Neuralgia	3.9%
771	Kleine-Levin Syndrome	3.9%
772	Agraphia	3.9%
773	Anomia	3.9%
774	Cluttering	3.9%
775	Language Development Disorders	3.9%
776	Speech Disorders	3.9%
777	Syncope	3.9%
778	Stupor	3.9%
779	Dysgraphia	3.9%
780	Presyncope	3.9%
781	Dyslalia	3.9%
782	Zellweger Syndrome	3.8%
783	Kearns-Sayre syndrome	3.7%
784	Cataplexy	3.7%
785	Aphasia	3.7%
786	Articulation Disorders	3.7%
787	Echolalia	3.7%
788	Stuttering	3.7%
789	Dysphasia	3.7%
790	Gaucher Disease	3.7%
791	Acoustic Neuroma	3.7%
792	Lemierre Syndrome	3.6%
793	Eye Injuries	3.6%
794	Duane Retraction Syndrome	3.6%
795	Tay-Sachs Disease	3.6%
796	Dysarthria	3.6%
797	Optic Atrophy, Hereditary, Leber	3.6%
798	Consciousness Disorders	3.6%
799	Mental Retardation	3.6%
800	Muscle Weakness	3.6%
801	Depressed Level of Consciousness	3.6%
802	Mental deficiency	3.6%
803	Intellectual Disability	3.6%
804	Muscular Dystrophy	3.5%
805	Congenital nystagmus	3.5%
806	Orbital Myositis	3.5%
807	Mobius Syndrome	3.5%
808	Bell Palsy	3.5%
809	Catatonia	3.5%
810	Diplopia	3.5%
811	Muscle Rigidity	3.5%
812	Muscle Spasticity	3.5%
813	Scotoma	3.5%
814	Photophobia	3.5%
815	Cogwheel Rigidity	3.5%
816	Hemifacial Spasm	3.5%
817	Amaurosis	3.5%
818	Blindness	3.5%
819	Nuchal Rigidity	3.5%
820	Herpes Zoster Oticus	3.5%
821	Familial Periodic Paralysis	3.5%
822	Aphonia	3.5%
823	Sleep Deprivation	3.5%
824	Dysphonia	3.5%
825	Agnosia	3.5%
826	Apraxias	3.5%
827	Hallucinations	3.5%
828	Hemianopsia	3.5%
829	Hyperacusis	3.5%
830	Tinnitus	3.5%
831	Visual Agnosia	3.5%
832	Anosognosia	3.5%
833	Wernicke-Korsakoff Syndrome	3.5%
834	Phonophobia	3.5%
835	Hearing Loss	3.5%
836	Sarcopenia	3.4%
837	Niemann-Pick Disease, Type C	3.3%
838	Eye Burns	3.1%
839	Welander Distal Myopathy	3.1%
840	Amaurosis Fugax	3.1%
841	Blindness, Cortical	3.1%
842	Dyscalculia	3.1%
843	Rett Syndrome	3.1%
844	Deafness	3.1%
845	Hearing Loss, Sudden	3.1%
846	Gerstmann Syndrome	3.1%
847	Hearing Loss, Bilateral	3.1%
848	Hearing Loss, High-Frequency	3.1%
849	Hearing Loss, Mixed Conductive-Sensorineural	3.1%
850	Prosopagnosia	3.1%
851	Apraxia, Ideomotor	3.1%
852	Charles Bonnet Syndrome	3.1%
853	Hearing Loss, Unilateral	3.1%
854	Complete Hearing Loss	3.1%
855	Alien Hand Syndrome	3.1%
856	Deaf Mutism	3.1%
857	Mutism	3%
858	Selective Mutism	3%
859	Myalgia	2.9%
860	Neuronal Ceroid-Lipofuscinoses	2.9%
861	Amnesia	2.9%
862	Delirium	2.9%
863	Dissociative Amnesia	2.9%
864	Color blindness	2.9%
865	Global Amnesia	2.9%
866	Cri-du-Chat Syndrome	2.9%
867	Down Syndrome	2.9%
868	Trisomy 21	2.9%
869	POEMS Syndrome	2.9%
870	Meningioma	2.9%
871	Williams Syndrome	2.9%
872	Microcephaly	2.8%
873	Macrocephaly	2.8%
874	Hypokalemic periodic paralysis	2.8%
875	Alexia, Pure	2.8%
876	Porencephaly	2.8%
877	Dermatomyositis	2.6%
878	Corneal Scar	2.6%
879	Aicardi's syndrome	2.6%
880	Hoarseness	2.6%
881	Muscular Dystrophy, Duchenne	2.6%
882	Cockayne Syndrome	2.6%
883	Alcohol Withdrawal Delirium	2.6%
884	Retrograde amnesia	2.6%
885	Amnesia, Anterograde	2.6%
886	Prader-Willi Syndrome	2.5%
887	Corneal Perforation	2.4%
888	Phantom pain	2.4%
889	Phantom Limb Pain	2.4%
890	Holoprosencephaly	2.3%
891	Fragile X Syndrome	2.2%
892	Rubinstein-Taybi Syndrome	1.9%
893	Mucopolysaccharidosis II	1.5%

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