MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Pectus excavatum

(UMLS:C2051831)

UMLS ID:: C2051831
MeSH ID:: D005660

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.099.386|C05.660.386

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.621.386

Synonym(s)

Pectus excavatum

Cobbler's chest

Funnel chest

Pectus recurvatum

Trichterbrust

pectus excavatum (funnel breast)

pectus excavatum was seen

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Valproic Acid	FAERS: 27	US FAERS
2	Valproic Acid	FAERS: 7	US FAERS
3	Venlafaxine Hydrochloride	FAERS: 7	US FAERS
4	Finasteride	FAERS: 4	US FAERS
5	Paroxetine	FAERS: 4	US FAERS
6	Isotretinoin	FAERS: 3	US FAERS
7	Ondansetron	FAERS: 3	US FAERS
8	Valproic Acid	FAERS: 3	US FAERS
9	4-hydroxybutyric acid	FAERS: 2	US FAERS
10	Risperidone	FAERS: 2	US FAERS
11	Sertraline	FAERS: 2	US FAERS
12	Alprazolam	FAERS: 1	US FAERS
13	Azithromycin	FAERS: 1	US FAERS
14	Budesonide	FAERS: 1	US FAERS
15	Lamotrigine	FAERS: 1	US FAERS
16	Meprobamate	FAERS: 1	US FAERS
17	NuvaRing	FAERS: 1	US FAERS
18	Warfarin	FAERS: 1	US FAERS
19	deflazacort	FAERS: 1	US FAERS
20	rofecoxib	FAERS: 1	US FAERS
21	Alcohols		OFFSIDES
22	Bupropion		OFFSIDES
23	Caffeine		OFFSIDES
24	Chlorhexidine		OFFSIDES
25	Clomiphene		SIDER
26	Methyldopa		OFFSIDES
27	Norethindrone Acetate		OFFSIDES
28	Vigabatrin		OFFSIDES
29	Vitamin B 12		OFFSIDES
30	Zoledronic Acid		OFFSIDES
31	chlorhexidine gluconate		OFFSIDES
32	exemestane		OFFSIDES
33	pirbuterol		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Klippel-Feil Syndrome	47.5%
2	Synostosis	47.5%
3	Platybasia	45.5%
4	Acrocephalosyndactylia	45.3%
5	Pectus carinatum	45.3%
6	Craniosynostosis	44.7%
7	Syndactyly	44.7%
8	Brachycephaly	44.7%
9	Arthrogryposis	42.6%
10	Limb Deformities, Congenital	39.7%
11	Craniofacial Abnormalities	39.7%
12	Craniofacial Dysostosis	38.3%
13	Poland Syndrome	37.2%
14	Gastroschisis	32.8%
15	Rubinstein-Taybi Syndrome	32.2%
16	Gigantism	29.2%
17	Amelia	28.9%
18	Arachnodactyly	28.9%
19	Ectromelia	28.9%
20	Hemimelia	28.9%
21	Phocomelia	28.9%
22	Sirenomelia	28.9%
23	Polydactyly	28.9%
24	Brachydactyly	28.9%
25	Plagiocephaly	28.9%
26	Lower Extremity Deformities, Congenital	28.9%
27	Upper Extremity Deformities, Congenital	28.9%
28	Dysostoses	28.8%
29	Goldenhar Syndrome	28.3%
30	Antley-Bixler Syndrome Phenotype	28%
31	Osteoarthropathy, Secondary Hypertrophic	27.8%
32	Multiple Epiphyseal Dysplasia	27.4%
33	Osteochondrodysplasias	27.4%
34	Mandibulofacial Dysostosis	27.1%
35	Holoprosencephaly	26.7%
36	Maxillofacial Abnormalities	26.6%
37	Talipes	24.5%
38	Microcephaly	23.9%
39	Macrocephaly	23.9%
40	Dwarfism	23.5%
41	Osteochondritis	23%
42	Hyperostosis	22.4%
43	Osteitis	22.4%
44	Osteitis Deformans	22.4%
45	Osteochondrosis	22.4%
46	Spinal Diseases	22.4%
47	Jaw Abnormalities	21.9%
48	Chondrodysplasia Punctata	21.8%
49	Enchondromatosis	21.8%
50	Osteosclerosis	21.8%
51	Kashin-Beck Disease	21.8%
52	Congenital clubfoot	21.5%
53	Vertical Talus	21.5%
54	Marfan Syndrome	20.7%
55	Congenital Hypothyroidism	20.3%
56	Spinal Neoplasms	20.2%
57	Spondylitis	20.2%
58	Porencephaly	20.2%
59	Fasciitis	19.6%
60	Foot Deformities	19.6%
61	Arthropathy	19.6%
62	Contracture	19.4%
63	Fasciitis, Plantar	19.4%
64	Noonan Syndrome	19.4%
65	Bone Diseases, Endocrine	18.6%
66	Melorheostosis	18.4%
67	Osteopetrosis	18.4%
68	Laryngomalacia	18.1%
69	Osteogenesis Imperfecta	18.1%
70	Bone Diseases, Infectious	18.1%
71	Bone neoplasms	18.1%
72	Osteopenia	18.1%
73	Micrognathism	18%
74	Pierre Robin Syndrome	18%
75	Osteoarthritis, Spine	18%
76	Bone Resorption	17.8%
77	Aseptic Necrosis of Bone	17.8%
78	Prognathism	17.8%
79	Cockayne Syndrome	17.1%
80	Retrognathia	16.2%
81	Jaw Diseases	16.2%
82	Fibromyalgia	16.1%
83	Polymyalgia Rheumatica	16.1%
84	Basal Cell Nevus Syndrome	16%
85	Metatarsalgia	16%
86	Cleft Palate	16%
87	Beckwith-Wiedemann Syndrome	15.7%
88	Wolf-Hirschhorn Syndrome	15.7%
89	Cartilage Diseases	15.7%
90	Foot Diseases	15.7%
91	Myopathy	15.7%
92	Rheumatism	15.7%
93	Chondromalacia	15.7%
94	Nail-Patella Syndrome	15.7%
95	Gout	15.5%
96	Abnormalities, Drug-Induced	15.5%
97	Situs Inversus	15.5%
98	Discitis	15.5%
99	Ankylosing spondylitis	15.4%
100	Ainhum	15.3%
101	Spinal Stenosis	15.3%
102	Spondylosis	15.3%
103	Intervertebral Disc Degeneration	15.3%
104	Bronchomalacia	14.8%
105	Tracheomalacia	14.8%
106	Ischemic contracture	14.4%
107	Temporomandibular Joint Disorders	13.8%
108	Smith-Magenis syndrome	13.6%
109	Rheumatic Fever	13.6%
110	Hip Contracture	13.5%
111	Periarthritis	13.5%
112	Cri-du-Chat Syndrome	13.4%
113	Down Syndrome	13.4%
114	Trisomy 21	13.4%
115	Spondylarthropathies	13.3%
116	Aicardi's syndrome	13.2%
117	Arthritis, Psoriatic	13.2%
118	Tuberculosis, Spinal	13.2%
119	Temporomandibular Joint Dysfunction Syndrome	13%
120	Eye Abnormalities	12.9%
121	Cardiovascular Abnormalities	12.9%
122	Skin Abnormalities	12.5%
123	Lymphatic Abnormalities	12.5%
124	Congenital Microtia	12.5%
125	Arthritis, Reactive	12.2%
126	Congenital diaphragmatic hernia	12.2%
127	Osteomyelitis	12.2%
128	Osteoporosis	12.2%
129	Periostitis	12.2%
130	Bone Demineralization, Pathologic	12.2%
131	Post-Traumatic Osteoporosis	12.2%
132	Alveolar Bone Loss	12.1%
133	Femur Head Necrosis	12.1%
134	Osteoarthritis, Knee	12.1%
135	Osteolysis	12.1%
136	Arthritis	12.1%
137	Bursitis	12.1%
138	Joint Instability	12.1%
139	Myofascial Pain Syndromes	12.1%
140	Rhabdomyolysis	12.1%
141	Synovitis	12.1%
142	Joint laxity	12.1%
143	Polyarthritis	12.1%
144	Frozen shoulder	12.1%
145	Patellofemoral Pain Syndrome	12.1%
146	Rheumatoid Arthritis	11.8%
147	Ectodermal Dysplasia	11.8%
148	Lordosis	11.8%
149	Spondylolysis	11.8%
150	Aplasia Cutis Congenita	11.8%
151	kyphosis	11.8%
152	Juvenile arthritis	11.8%
153	Anencephaly	11.7%
154	Arthritis, Gouty	11.7%
155	Prader-Willi Syndrome	11.7%
156	Eosinophilic Granuloma	10.9%
157	Bone Diseases	10.7%
158	Urogenital Abnormalities	10.7%
159	CHARGE Syndrome	10.2%
160	Prune Belly Syndrome	10.2%
161	Twins, Conjoined	10.2%
162	Waardenburg Syndrome	10.2%
163	Dural Arteriovenous Fistula	10.1%
164	Kartagener Syndrome	10.1%
165	Dextrocardia	10%
166	Spondylolisthesis	10%
167	Acromegaly	10%
168	Joint Tuberculosis	10%
169	Tuberculosis, Osteoarticular	10%
170	Bone Tuberculosis	10%
171	Rheumatoid Nodule	10%
172	Compartment syndromes	9.7%
173	Maxillary Diseases	9.7%
174	Tendinitis	9.7%
175	Tendinopathy	9.7%
176	Hemarthrosis	9.6%
177	Myositis	9.6%
178	Tietze's Syndrome	9.6%
179	Isaacs syndrome	9.6%
180	Myotonic Disorders	9.6%
181	Osteoporosis, Postmenopausal	9.3%
182	Muscular Dystrophy	9%
183	Genetic Diseases, Inborn	8.9%
184	Pseudohypoparathyroidism	8.7%
185	Xeroderma	8.7%
186	Mobius Syndrome	8.7%
187	Myotonic Dystrophy	8.6%
188	Rickets	8.6%
189	Felty Syndrome	8.6%
190	Bunion	8.5%
191	Fibrodysplasia Ossificans Progressiva	8.5%
192	Myoglobinuria	8.5%
193	Myositis Ossificans	8.5%
194	Tenosynovitis	8.5%
195	Sacroiliitis	8.5%
196	Anophthalmos	8.2%
197	Anus, Imperforate	8.2%
198	Hydranencephaly	8.2%
199	Microphthalmos	8.2%
200	Neural Tube Defects	8.2%
201	Tethered Cord Syndrome	8.2%
202	Iniencephaly	8.2%
203	Craniorachischisis	8.2%
204	Exencephaly	8.2%
205	Septo-Optic Dysplasia	8.2%
206	Cortical Dysplasia	8.2%
207	Malformations of Cortical Development	8.2%
208	Anorectal Malformations	8.2%
209	Familial Periodic Paralysis	8.2%
210	Bloom Syndrome	8.1%
211	Palatal Neoplasms	8.1%
212	Medial Tibial Stress Syndrome	8%
213	Scimitar Syndrome	8%
214	Mitochondrial Myopathies	8%
215	Muscle Cramp	7.9%
216	Eosinophilia-Myalgia Syndrome	7.9%
217	Muscle Rigidity	7.8%
218	Muscle Spasticity	7.8%
219	Cogwheel Rigidity	7.8%
220	Nuchal Rigidity	7.8%
221	Mastoiditis	7.7%
222	Petrositis	7.7%
223	Alstrom Syndrome	7.7%
224	Muscular Dystrophy, Duchenne	7.6%
225	Polycystic Kidney Diseases	7.6%
226	Williams Syndrome	7.6%
227	Abnormalities, Radiation-Induced	7.6%
228	Rheumatoid Vasculitis	7.5%
229	Fragile X Syndrome	7.4%
230	Fetal Diseases	7.1%
231	Chronic Fatigue Syndrome	7.1%
232	Classical Lissencephalies and Subcortical Band Heterotopias	7%
233	Turner Syndrome	6.9%
234	Blepharophimosis	6.9%
235	Bone Diseases, Developmental	6.9%
236	Laryngostenosis	6.9%
237	Mouth Abnormalities	6.9%
238	Retinal Dysplasia	6.9%
239	Arthritis, Infectious	6.8%
240	Aniridia	6.8%
241	Giant Cell Epulis	6.8%
242	Muscle Weakness	6.8%
243	Esophageal Atresia	6.8%
244	Intestinal Atresia	6.8%
245	Horseshoe Kidney	6.8%
246	Pectus excavatum	6.8%
247	Musculoskeletal Pain	6.8%
248	Anterior Compartment Syndrome	6.8%
249	Enthesopathy	6.8%
250	Arthritis, Experimental	6.8%
251	Abdominal Compartment Syndrome	6.8%
252	Acrodermatitis	6.7%
253	Lymphangiectasis, Intestinal	6.7%
254	Gianotti-Crosti Syndrome	6.7%
255	Epidermolysis Bullosa	6.7%
256	Polymyositis	6.7%
257	Arthralgia	6.7%
258	Myotonia Congenita	6.7%
259	Polyarthralgia	6.7%
260	Welander Distal Myopathy	6.6%
261	Sicca Syndrome	6.6%
262	Sjogren's Syndrome	6.6%
263	Ichthyosis, X-Linked	6.6%
264	Primary Ciliary Dyskinesia	6.6%
265	Smith-Lemli-Opitz Syndrome	6.6%
266	Osteomalacia	6.6%
267	Ectopia Cordis	6%
268	Meningomyelocele	6%
269	Spina Bifida	6%
270	Single umbilical artery	6%
271	Cystic Fibrosis	6%
272	Choanal Atresia	5.9%
273	Tracheobronchomegaly	5.9%
274	Laryngocele	5.9%
275	Hypokalemic periodic paralysis	5.9%
276	Choledochal Cyst	5.9%
277	Hermaphroditism	5.9%
278	Disorders of Sex Development	5.9%
279	Myalgia	5.8%
280	Cryptorchidism	5.8%
281	Hypospadias	5.8%
282	Central Nervous System Cysts	5.8%
283	Dandy-Walker Syndrome	5.8%
284	Hip Dislocation	5.7%
285	Shoulder Dislocation	5.7%
286	Hip Dysplasia	5.7%
287	Klinefelter Syndrome	5.7%
288	POEMS Syndrome	5.7%
289	Orbital Myositis	5.6%
290	Polycystic Kidney, Autosomal Dominant	5.6%
291	Dupuytren Contracture	5.6%
292	Pyomyositis	5.6%
293	Pseudoxanthoma Elasticum	5.4%
294	Sjogren-Larsson Syndrome	5.3%
295	Abdominal Cramps	5.2%
296	Amniotic Band Syndrome	5.2%
297	Asphyxia Neonatorum	5.2%
298	Infant, Premature, Diseases	5.2%
299	Meconium Aspiration Syndrome	5.2%
300	Infantile Colic	5.2%
301	Bladder Exstrophy	5.1%
302	Epispadias	5.1%
303	Multicystic Dysplastic Kidney	5%
304	Aortic coarctation	5%
305	Cor Triatriatum	5%
306	Coronary Vessel Anomalies	5%
307	Dental Enamel Hypoplasia	5%
308	Patent ductus arteriosus	5%
309	Ebstein Anomaly	5%
310	Heart Septal Defects	5%
311	Hypodontia	5%
312	Macrostomia	5%
313	Meningocele	5%
314	Microstomia	5%
315	Tetralogy of Fallot	5%
316	Transposition of Great Vessels	5%
317	Hypoplastic Left Heart Syndrome	5%
318	May-Thurner Syndrome	5%
319	Encephalocele	5%
320	Dermal Sinus	5%
321	Spina Bifida Cystica	5%
322	Spina Bifida Occulta	5%
323	Lissencephaly	5%
324	Polymicrogyria	5%
325	Pachygyria	5%
326	Schizencephaly	5%
327	Periventricular Nodular Heterotopia	5%
328	Kallmann Syndrome	5%
329	Wolff-Parkinson-White Syndrome	5%
330	Charcot-Marie-Tooth Disease	4.9%
331	Xeroderma Pigmentosum	4.9%
332	Hyperkeratosis, Epidermolytic	4.9%
333	Nose Neoplasms	4.8%
334	Shoulder Pain	4.7%
335	Renal Osteodystrophy	4.6%
336	Renal rickets	4.6%
337	Zellweger Syndrome	4.6%
338	Hyperandrogenism	4.4%
339	Tuberous Sclerosis	4.4%
340	Long QT Syndrome	4.3%
341	Tricuspid Atresia	4.3%
342	Arrhythmogenic Right Ventricular Dysplasia	4.3%
343	Gonadal Dysgenesis	4.3%
344	Neoplastic Syndromes, Hereditary	4.3%
345	Adrenogenital Syndrome	4.3%
346	Ovotesticular Disorders of Sex Development	4.3%
347	Refsum Disease	4.2%
348	Mitochondrial Encephalomyopathies	4.1%
349	Aortopulmonary Septal Defect	4.1%
350	Double Outlet Right Ventricle	4.1%
351	Endocardial Cushion Defects	4.1%
352	Myocardial bridging	4.1%
353	Aorticopulmonary Septal Defect	4.1%
354	Anemia, Neonatal	4.1%
355	Pelger-Huet Anomaly	4.1%
356	Persistent Fetal Circulation Syndrome	4.1%
357	Werner Syndrome	4.1%
358	Myasthenic Syndromes, Congenital	4.1%
359	Umbilical hernia	4.1%
360	Dermatomyositis	3.9%
361	Anemia, Sickle Cell	3.8%
362	Thalassemia	3.8%
363	Truncus Arteriosus, Persistent	3.7%
364	Albinism	3.7%
365	Familial Hypophosphatemic Rickets	3.6%
366	Romano-Ward Syndrome	3.5%
367	Neonatal Abstinence Syndrome	3.5%
368	Fetal Growth Retardation	3.4%
369	Familial Mediterranean Fever	3.4%
370	Fetal Hypoxia	3.4%
371	Congenital nystagmus	3.4%
372	Fetal Alcohol Spectrum Disorders	3.4%
373	Toxoplasmosis, Congenital	3.4%
374	Syphilis, Congenital	3.4%
375	Rett Syndrome	3.3%
376	Mucopolysaccharidosis II	3.2%
377	Menkes Kinky Hair Syndrome	3%
378	MELAS Syndrome	3%
379	Wiskott-Aldrich Syndrome	3%
380	Autoimmune Lymphoproliferative Syndrome	2.9%
381	Congenital Hyperinsulinism	2.9%
382	Chorioamnionitis	2.9%
383	Radicular Cyst	2.9%
384	Angioedemas, Hereditary	2.9%
385	Sickle Cell Trait	2.8%
386	Arteriovenous fistula	2.8%
387	Paralysis, Obstetric	2.7%
388	Retinopathy of Prematurity	2.7%
389	Amino Acid Metabolism, Inborn Errors	2.7%
390	Carbohydrate Metabolism, Inborn Errors	2.7%
391	Metal Metabolism, Inborn Errors	2.7%
392	Progeria	2.7%
393	Lysosomal Storage Diseases	2.7%
394	Cytochrome-c Oxidase Deficiency	2.7%
395	Peroxisomal Disorders	2.7%
396	Neuronal Ceroid-Lipofuscinoses	2.7%
397	Bronchopulmonary Dysplasia	2.7%
398	Adrenoleukodystrophy	2.5%
399	Hepatolenticular Degeneration	2.4%
400	Fabry Disease	2.3%
401	Amyloid Neuropathies, Familial	2.3%
402	Respiratory Distress Syndrome, Newborn	2.3%
403	Cutis Laxa	2.3%
404	Denys-Drash Syndrome	2.3%
405	Retinitis Pigmentosa	2.3%
406	Pigmentary retinopathy	2.3%
407	Porokeratosis	2.2%
408	Keratoderma, Palmoplantar	2.2%
409	Chronic granulomatous disease	2.2%
410	Acute Chest Syndrome	2.2%
411	Ophthalmia Neonatorum	2.2%
412	Glycogen storage disease type II	2.2%
413	Galactosemias	2.2%
414	Urea Cycle Disorders, Inborn	2.2%
415	Tyrosinemias	2.2%
416	Hydrops Fetalis	2.2%
417	Mucopolysaccharidosis III	2%
418	Ataxia Telangiectasia	2%
419	Kearns-Sayre syndrome	2%
420	Alkaptonuria	2%
421	Glycogen Storage Disease	2%
422	Hypophosphatasia	2%
423	Propionic acidemia	2%
424	Dihydropyrimidine Dehydrogenase Deficiency	2%
425	Cystinosis	2%
426	Optic Atrophy, Hereditary, Leber	2%
427	Hyperphosphaturia	2%
428	Duane Retraction Syndrome	2%
429	Porphyrias, Hepatic	1.9%
430	Canavan Disease	1.9%
431	Alexander Disease	1.9%
432	Peutz-Jeghers Syndrome	1.9%
433	Thrombasthenia	1.9%
434	Antithrombin III Deficiency	1.9%
435	Protein C Deficiency	1.9%
436	Brain Diseases, Metabolic, Inborn	1.9%
437	Afibrinogenemia	1.9%
438	Dystonia Musculorum Deformans	1.9%
439	Factor VII Deficiency	1.9%
440	Factor X Deficiency	1.9%
441	Factor XII Deficiency	1.9%
442	Hemophilia A	1.9%
443	Leukomalacia, Periventricular	1.9%
444	Activated Protein C Resistance	1.9%
445	Factor II deficiency	1.9%
446	Factor VIII Deficiency	1.9%
447	Factor V deficiency	1.9%
448	Factor XI Deficiency	1.9%
449	Hypoprothrombinemias	1.9%
450	Fanconi Anemia	1.9%
451	Nesidioblastosis	1.9%
452	Lafora Disease	1.9%
453	Unverricht-Lundborg Syndrome	1.9%
454	Anemia, Diamond-Blackfan	1.9%
455	Homocystinuria	1.8%
456	Gaucher Disease	1.8%
457	Leigh Disease	1.8%
458	Multiple Endocrine Neoplasia	1.7%
459	Dermatitis, Atopic	1.7%
460	Hyaline Membrane Disease	1.7%
461	Hypolipoproteinemias	1.7%
462	Papillon-Lefevre Disease	1.7%
463	Glycogen Storage Disease Type I	1.7%
464	Glycogen Storage Disease Type V	1.7%
465	Hyperlipidemia, Familial Combined	1.7%
466	Hyperlipoproteinemia Type III	1.7%
467	Tay-Sachs Disease	1.6%
468	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.6%
469	Niemann-Pick Disease, Type C	1.6%
470	Kernicterus	1.5%
471	Behcet Syndrome	1.5%
472	Lactose Intolerance	1.4%
473	Variegate Porphyria	1.4%
474	Acute intermittent porphyria	1.4%
475	Porphyria Cutanea Tarda	1.4%
476	Hyperhomocysteinemia	1.4%
477	Renal Aminoacidurias	1.4%
478	Fanconi Syndrome	1.4%
479	Pseudohypoaldosteronism	1.4%
480	Liddle Syndrome	1.4%
481	Hyperlipoproteinemia Type IV	1.4%
482	Hyperlipoproteinemia Type V	1.4%
483	Hypoalphalipoproteinemias	1.4%
484	Huntington Disease	1.3%
485	Multiple Endocrine Neoplasia Type 1	1.3%
486	Friedreich Ataxia	1.2%
487	Renal tubular acidosis	1.2%
488	Nephroblastoma	1.2%
489	Cystinuria	1.2%
490	Adenomatous Polyposis Coli	1.1%
491	Glycosuria, Renal	1%

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