MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Multiple Endocrine Neoplasia Type 1

(UMLS:C0025267)

Definition:: A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).
UMLS ID:: C0025267
MeSH ID:: D018761

Classification 1:

Name:

Neoplasms
MeSH Tree Number(s):: C04.588.322.400.500|C04.651.600.500|C04.700.630.500

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.700.630.500

Classification 3:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.344.400.500

Synonym(s)

Multiple Endocrine Neoplasia Type 1

ADENOMATOSIS, POLYGLANDULAR

ENDOCRINE ADENOMA PEPTIC ULCER COMPLEX

MEA Type 1

MEA Type I

MEA syndrome, type I

MEA, type 1

MEN 1 - Multiple endocrine neoplasia syndrome type 1

MEN 1 syndrome

10.

MEN Type 1

11.

MEN Type I

12.

MEN, type 1

13.

MEN1 syndrome

14.

MULTIPLE ENDOCRINE NEOPLASIA TYPE 1

15.

MULTIPLE ENDOCRINE NEOPLASIA, TYPE I

16.

Multiple Endocrine Adenomatosis

17.

Multiple Endocrine Adenomatosis Type 1

18.

Multiple Endocrine Adenomatosis Type I

19.

Multiple Endocrine Adenomatosis, Type I

20.

Multiple Endocrine Neoplasia Type I

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Octreotide	FAERS: 2	US FAERS
2	Cinacalcet	FAERS: 1	US FAERS
3	Omeprazole	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Parathyroid Neoplasms	26.1%
2	Thyroid Neoplasm	26.1%
3	Thyroid carcinoma	26.1%
4	Tuberous Sclerosis	25.6%
5	Adrenal Gland Neoplasms	22.3%
6	Pancreatic Neoplasm	21.6%
7	Testicular Neoplasms	19%
8	Peutz-Jeghers Syndrome	18.3%
9	Nephroblastoma	17.8%
10	Thyroid Nodule	17.5%
11	Basal Cell Nevus Syndrome	17%
12	ovarian neoplasm	16.9%
13	Hamartoma	16.5%
14	Neoplasms, Hormone-Dependent	16.5%
15	Paraneoplastic Syndromes	16.5%
16	Precancerous Conditions	16.5%
17	Neoplasms, Second Primary	16.5%
18	Carcinoma, Pancreatic Ductal	15.3%
19	Pituitary Adenoma	15.3%
20	Pituitary Neoplasms	15.3%
21	Adenomatous Polyposis Coli	15%
22	Abdominal Neoplasms	15%
23	Head and Neck Neoplasms	15%
24	Soft Tissue Neoplasms	15%
25	Thoracic Neoplasms	15%
26	Prolactinoma	14.4%
27	Growth Hormone-Secreting Pituitary Adenoma	14.4%
28	Paraneoplastic Encephalomyelitis	14.3%
29	Cyst	14.2%
30	Neoplastic Processes	14.2%
31	Pregnancy Complications, Neoplastic	14.2%
32	Mammary Neoplasms, Experimental	14.1%
33	Neoplasms, Experimental	14.1%
34	Digestive System Neoplasms	13.2%
35	Eye Neoplasms	13.2%
36	Nervous System Neoplasms	13.2%
37	Carcinoma 256, Walker	13%
38	Bone neoplasms	13%
39	Skin Neoplasms	13%
40	Hematologic Neoplasms	13%
41	Splenic Neoplasms	12.9%
42	granulosa cell tumor	12.7%
43	Carcinoma, Ovarian Epithelial	12.7%
44	Peritoneal Neoplasms	12.7%
45	Neoplasms, Radiation-Induced	12.3%
46	Vipoma	12.2%
47	Adrenocortical carcinoma	12%
48	Melanoma, Experimental	11.9%
49	insulinoma	11.9%
50	Carcinoma, Ehrlich Tumor	11.8%
51	Dermoid Cyst	11.8%
52	Carcinoma, Lewis Lung	11.8%
53	Acanthoma	11.7%
54	Gastrinoma	11.7%
55	Glucagonoma	11.7%
56	Trophoblastic Neoplasms	11.7%
57	Leukemia, Experimental	11.6%
58	Meningioma	11.5%
59	Carcinoma, Lobular	11.4%
60	Leydig Cell Tumor	11.2%
61	Neoplasms, Neuroepithelial	11.1%
62	Gliomatosis cerebri	11.1%
63	Neoplasms, Multiple Primary	10.8%
64	Tracheal Neoplasms	10.8%
65	Dwarfism	10.7%
66	Medulloblastoma	10.5%
67	Leukemia, Radiation-Induced	10.4%
68	Neuroectodermal Tumors	10.4%
69	Sarcoma, Experimental	10.3%
70	Denys-Drash Syndrome	10.2%
71	Multiple Endocrine Neoplasia	10.1%
72	Nelson Syndrome	9.9%
73	melanoma	9.8%
74	Liver Neoplasms, Experimental	9.6%
75	Esophageal Neoplasms	9.6%
76	Thymoma	9.5%
77	Erythroplasia	9.4%
78	Follicular cyst	9.4%
79	leukemia	9.4%
80	Mucocele	9.4%
81	Neoplasms, Germ Cell and Embryonal	9.4%
82	Neoplasms, Glandular and Epithelial	9.4%
83	Pilonidal Cyst	9.4%
84	Thyroglossal Cyst	9.4%
85	Synovial Cyst	9.4%
86	Germ Cell Cancer	9.4%
87	Aberrant Crypt Foci	9.4%
88	Retroperitoneal Neoplasms	9.3%
89	Neoplastic Syndromes, Hereditary	9.3%
90	Choriocarcinoma	9.3%
91	Retinoblastoma	9%
92	Acoustic Neuroma	9%
93	Carcinosarcoma	8.9%
94	Hemangiosarcoma	8.9%
95	Leukemia L1210	8.9%
96	Leukemia P388	8.9%
97	lymphangiosarcoma	8.9%
98	Corpus Luteum Cyst	8.7%
99	Ovarian Cysts	8.7%
100	Lymphomatoid Granulomatosis	8.5%
101	Adenoma, Acidophil	8.5%
102	Ganglioneuroma	8.5%
103	Glioma	8.5%
104	Malignant Glioma	8.5%
105	Leukoplakia, Oral	8.4%
106	Paraneoplastic Cerebellar Degeneration	8.4%
107	Sarcoma 180	8.2%
108	Leukoplakia	8.2%
109	Lymphocele	8.2%
110	Pancreatic Cyst	8.2%
111	Barrett Esophagus	8.1%
112	Breast Cyst	8.1%
113	Histiocytic Disorders, Malignant	8.1%
114	Actinic keratosis	8.1%
115	Mediastinal Cyst	8.1%
116	Mouth Neoplasms	8.1%
117	Neoplasm Invasiveness	8.1%
118	Neoplasm Metastasis	8.1%
119	Neoplasm Recurrence, Local	8.1%
120	Parovarian Cyst	8.1%
121	Pericardial Cyst	8.1%
122	Thymic Cyst	8.1%
123	Central Nervous System Neoplasms	8.1%
124	Vascular Neoplasms	8.1%
125	Carcinogenesis	8.1%
126	Myxoid cyst	8.1%
127	Thymus Neoplasms	8.1%
128	Metastasis	8.1%
129	Composite Lymphoma	8%
130	Genital Neoplasms, Female	8%
131	Breast Neoplasms, Male	8%
132	Triple Negative Breast Neoplasms	8%
133	Carcinoid Tumor	7.9%
134	Neurilemmoma	7.9%
135	Hutchinson's Melanotic Freckle	7.9%
136	Melanoma, Amelanotic	7.9%
137	Leukemia, Plasma Cell	7.8%
138	Optic Nerve Glioma	7.7%
139	Aicardi's syndrome	7.6%
140	Cystic Fibrosis	7.6%
141	Limbic Encephalitis	7.5%
142	CHARGE Syndrome	7.5%
143	Basal cell carcinoma	7.5%
144	Carcinoma, Papillary	7.5%
145	Squamous cell carcinoma	7.5%
146	Chondrosarcoma	7.5%
147	Craniopharyngioma	7.5%
148	Cystadenoma	7.5%
149	leiomyosarcoma	7.5%
150	liposarcoma	7.5%
151	Mesothelioma	7.5%
152	synovial sarcoma	7.5%
153	Neuroectodermal Tumor, Melanotic	7.5%
154	Angiomyolipoma	7.5%
155	Clear Cell Sarcoma of Soft Tissue	7.5%
156	Alveolar Soft Part Sarcoma	7.5%
157	Neuroendocrine Tumors	7.5%
158	Sarcoma, Myeloid	7.5%
159	Carcinoma, Basal Cell	7.5%
160	Choledochal Cyst	7.5%
161	Xeroderma Pigmentosum	7.4%
162	Hepatocellular Adenoma	7.3%
163	Astrocytoma	7.3%
164	Ependymoma	7.3%
165	oligodendroglioma	7.3%
166	Ganglioglioma	7.3%
167	gliosarcoma	7.3%
168	Anaplastic astrocytoma	7.3%
169	Anaplastic Oligodendroglioma	7.3%
170	Gastrointestinal Neoplasms	7.1%
171	Genital Neoplasms, Male	7.1%
172	Liver neoplasms	7.1%
173	Multiple Epiphyseal Dysplasia	7.1%
174	Osteochondrodysplasias	7.1%
175	Pelger-Huet Anomaly	7.1%
176	Uveal Neoplasms	7.1%
177	Werner Syndrome	7.1%
178	Myasthenic Syndromes, Congenital	7.1%
179	Lymphoma	7.1%
180	Urologic Neoplasms	7.1%
181	Sebaceous Gland Neoplasms	7%
182	Spinal Neoplasms	7%
183	Bone Marrow Neoplasms	7%
184	Kallmann Syndrome	7%
185	Malignant Carcinoid Syndrome	7%
186	Lambert-Eaton Myasthenic Syndrome	6.9%
187	Ichthyosis, X-Linked	6.8%
188	Cystadenocarcinoma	6.8%
189	Fibrosarcoma	6.8%
190	Osteosarcoma	6.8%
191	Mucoepidermoid Carcinoma	6.8%
192	Nose Neoplasms	6.7%
193	Nail-Patella Syndrome	6.7%
194	Glioblastoma	6.7%
195	Neuroblastoma	6.7%
196	Glioblastoma Multiforme	6.7%
197	Albinism	6.6%
198	Anemia, Sickle Cell	6.6%
199	Thalassemia	6.6%
200	Multiple Endocrine Neoplasia Type 1	6.6%
201	Muscular Dystrophy, Duchenne	6.6%
202	Fragile X Syndrome	6.5%
203	Adenofibroma	6.4%
204	Fibroadenoma	6.4%
205	Malignant Fibrous Histiocytoma	6.4%
206	Palatal Neoplasms	6.4%
207	Ganglioneuroblastoma	6.4%
208	Opsoclonus-Myoclonus Syndrome	6.4%
209	Congenital Hypothyroidism	6.3%
210	Endometrial Stromal Sarcoma	6.3%
211	Cockayne Syndrome	6.3%
212	Muscular Dystrophy	6.2%
213	Osteogenesis Imperfecta	6.2%
214	Beckwith-Wiedemann Syndrome	6.2%
215	Wolf-Hirschhorn Syndrome	6.2%
216	Mesoblastic Nephroma	6.1%
217	Neurofibrosarcoma	6%
218	Bowen's Disease	6%
219	Paraganglioma	6%
220	Rhabdomyosarcoma	6%
221	Giant Cell Tumor of Bone	6%
222	Adenoma	6%
223	Ameloblastoma	6%
224	Angiokeratoma	6%
225	Carcinoma	6%
226	Chordoma	6%
227	Hemangioma	6%
228	hemangiopericytoma	6%
229	Lymphangioma	6%
230	Mesenchymoma	6%
231	Nevus	6%
232	Teratoma	6%
233	Hepatoblastoma	6%
234	Mixed Tumor, Mullerian	6%
235	Germinoma	6%
236	Teratocarcinoma	6%
237	Angiofibroma	6%
238	Sarcoma	6%
239	Epithelioma	6%
240	Hydatidiform Mole	5.9%
241	Endocrine Gland Neoplasms	5.9%
242	Carcinoid Heart Disease	5.9%
243	Alstrom Syndrome	5.8%
244	Myelitis, Transverse	5.8%
245	Lymphangioleiomyomatosis	5.8%
246	Polycystic Ovary Syndrome	5.7%
247	Dermatofibrosarcoma	5.7%
248	Dermatofibrosarcoma Protuberans	5.7%
249	Adrenal Gland Diseases	5.7%
250	Gonadal Disorders	5.7%
251	Parathyroid Diseases	5.7%
252	Thyroid Diseases	5.7%
253	Kartagener Syndrome	5.7%
254	Meningeal Neoplasms	5.6%
255	Autoimmune Lymphoproliferative Syndrome	5.6%
256	Marfan Syndrome	5.6%
257	Smith-Magenis syndrome	5.6%
258	Central Nervous System Cysts	5.5%
259	Cri-du-Chat Syndrome	5.5%
260	Down Syndrome	5.5%
261	Angioedemas, Hereditary	5.5%
262	Trisomy 21	5.5%
263	Wiskott-Aldrich Syndrome	5.4%
264	Pheochromocytoma	5.3%
265	Alveolar rhabdomyosarcoma	5.3%
266	Holoprosencephaly	5.2%
267	Mucopolysaccharidosis II	5.2%
268	Carcinoma, Endometrioid	5.2%
269	Menkes Kinky Hair Syndrome	5.2%
270	Pancreatic Pseudocyst	5.2%
271	Plasmacytoma	5.2%
272	Malignant histiocytosis	5.2%
273	Lymphatic Metastasis	5.2%
274	Neoplasms, Unknown Primary	5.2%
275	Leukemic Infiltration	5.2%
276	Histiocytic sarcoma	5.2%
277	Neoplasm Micrometastasis	5.2%
278	Deformity	5.1%
279	Ear Neoplasms	5%
280	Eyelid Neoplasms	5%
281	Lung Neoplasms	5%
282	Pleural Neoplasms	5%
283	Adrenoleukodystrophy	5%
284	Ectodermal Dysplasia	5%
285	Aplasia Cutis Congenita	5%
286	Familial Mediterranean Fever	4.9%
287	Brain Neoplasms	4.9%
288	Salivary Gland Neoplasms	4.9%
289	Spinal Cord Neoplasms	4.9%
290	Tongue Neoplasms	4.9%
291	Prader-Willi Syndrome	4.9%
292	Myotonic Dystrophy	4.9%
293	Bone Diseases, Endocrine	4.9%
294	Uterine Neoplasms	4.9%
295	Vaginal Neoplasms	4.9%
296	Vulvar Neoplasms	4.9%
297	Uterine Cancer	4.9%
298	Fallopian Tube Neoplasms	4.9%
299	Rett Syndrome	4.9%
300	Diabetes Mellitus	4.9%
301	Pituitary Diseases	4.8%
302	Renal Cell Carcinoma	4.7%
303	Papillary Renal Cell Carcinoma	4.7%
304	Rubinstein-Taybi Syndrome	4.7%
305	Hodgkin Disease	4.5%
306	Lymphoma, Non-Hodgkin	4.5%
307	Pharyngeal Neoplasms	4.5%
308	Smith-Lemli-Opitz Syndrome	4.5%
309	Meningeal Carcinomatosis	4.4%
310	Fetal Diseases	4.4%
311	Neuronal Ceroid-Lipofuscinoses	4.4%
312	Bile Duct Neoplasms	4.4%
313	gallbladder neoplasm	4.4%
314	Intestinal Neoplasms	4.4%
315	Penile Neoplasms	4.4%
316	Prostatic Neoplasms	4.4%
317	Stomach Neoplasms	4.4%
318	Nasopharyngeal carcinoma	4.4%
319	Adenocarcinoma	4.4%
320	Carcinoma in Situ	4.4%
321	Carcinoma, Transitional Cell	4.4%
322	Phyllodes Tumor	4.4%
323	Dysgerminoma	4.4%
324	Hemangioendothelioma	4.4%
325	Polycystic Kidney Diseases	4.4%
326	Lipoma	4.4%
327	Myoma	4.4%
328	Myxoma	4.4%
329	Neuroma	4.4%
330	Papilloma	4.4%
331	Pseudomyxoma Peritonei	4.4%
332	Seminoma	4.4%
333	Williams Syndrome	4.4%
334	Papillomatosis	4.4%
335	Angiolipoma	4.4%
336	Myelolipoma	4.4%
337	Neoplasms, Bone Tissue	4.4%
338	Neoplasms, Fibrous Tissue	4.4%
339	Smooth Muscle Tumor	4.4%
340	Adenomatosis, Pulmonary	4.4%
341	Adenomatous Polyps	4.4%
342	Carcinoma, Large Cell	4.4%
343	Carcinoma, Small Cell	4.4%
344	Desmoplastic Small Round Cell Tumor	4.4%
345	Chondroma	4.4%
346	Enchondroma	4.4%
347	Polycythemia Vera	4.3%
348	Sickle Cell Trait	4.3%
349	Sjogren-Larsson Syndrome	4.3%
350	Hepatolenticular Degeneration	4.3%
351	Amino Acid Metabolism, Inborn Errors	4.2%
352	Carbohydrate Metabolism, Inborn Errors	4.2%
353	Metal Metabolism, Inborn Errors	4.2%
354	Progeria	4.2%
355	Lysosomal Storage Diseases	4.2%
356	Cytochrome-c Oxidase Deficiency	4.2%
357	Peroxisomal Disorders	4.2%
358	Primary Ciliary Dyskinesia	4.2%
359	Ataxia Telangiectasia	4.2%
360	Amyloid Neuropathies, Familial	4.1%
361	Laryngeal neoplasm	4.1%
362	Refsum Disease	4.1%
363	Retinal Dysplasia	4.1%
364	Primary amyloidosis	4%
365	Aniridia	4%
366	Epidermolysis Bullosa	4%
367	Bladder Neoplasm	3.9%
368	Kidney Neoplasm	3.9%
369	Ureteral Neoplasms	3.9%
370	Urethral Neoplasms	3.9%
371	Bronchial Neoplasms	3.9%
372	Klinefelter Syndrome	3.9%
373	Multiple Pulmonary Nodules	3.9%
374	Supratentorial Neoplasms	3.9%
375	Endometrial Neoplasms	3.9%
376	Fabry Disease	3.8%
377	Cutis Laxa	3.7%
378	Leukemia, Myelomonocytic, Chronic	3.7%
379	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	3.7%
380	Retinitis Pigmentosa	3.7%
381	Pigmentary retinopathy	3.7%
382	Porokeratosis	3.7%
383	Keratoderma, Palmoplantar	3.7%
384	Chronic granulomatous disease	3.7%
385	Welander Distal Myopathy	3.7%
386	Acute Chest Syndrome	3.6%
387	Galactosemias	3.5%
388	Urea Cycle Disorders, Inborn	3.5%
389	Tyrosinemias	3.5%
390	Adenoid Cystic Carcinoma	3.5%
391	fibroma	3.5%
392	Fibromatosis	3.5%
393	Osteoblastoma	3.5%
394	Osteoma	3.5%
395	Rhabdomyoma	3.5%
396	Chondromatosis	3.5%
397	Adenocarcinoma, Clear Cell	3.5%
398	Cholangiocarcinoma	3.5%
399	Cervical Intraepithelial Neoplasia	3.5%
400	Hemangioblastoma	3.5%
401	Lymphoma, Extranodal NK-T-Cell	3.5%
402	Hypopharyngeal Neoplasms	3.5%
403	Pleural Effusion, Malignant	3.5%
404	Hypopharyngeal Cancer	3.5%
405	Parotid Neoplasms	3.4%
406	Prostatic Neoplasms, Castration-Resistant	3.4%
407	Meconium Aspiration Syndrome	3.4%
408	Canavan Disease	3.4%
409	Alexander Disease	3.4%
410	Duane Retraction Syndrome	3.4%
411	Hermaphroditism	3.4%
412	Disorders of Sex Development	3.4%
413	Brain Stem Neoplasms	3.3%
414	Glycogen storage disease type II	3.3%
415	Adrenal Cortex Diseases	3.3%
416	Euthyroid Sick Syndromes	3.3%
417	Goiter	3.3%
418	Hyperparathyroidism	3.3%
419	Hyperthyroidism	3.3%
420	Hyperthyroxinemia	3.3%
421	Hypogonadism	3.3%
422	Hypoparathyroidism	3.3%
423	Hypothyroidism	3.3%
424	Delayed Puberty	3.3%
425	Precocious Puberty	3.3%
426	Thyroiditis	3.3%
427	Porphyrias, Hepatic	3.3%
428	Hypogonadotropic hypogonadism	3.3%
429	Testotoxicosis	3.3%
430	Secondary hypothyroidism	3.3%
431	Primary Hyperthyroidism	3.3%
432	Primary Hypothyroidism	3.3%
433	Pseudoxanthoma Elasticum	3.3%
434	Mastocytosis	3.3%
435	Sturge-Weber Syndrome	3.3%
436	Cell Transformation, Viral	3.3%
437	Myotonia Congenita	3.3%
438	Thrombasthenia	3.3%
439	Antithrombin III Deficiency	3.3%
440	Protein C Deficiency	3.3%
441	Brain Diseases, Metabolic, Inborn	3.3%
442	Waldenstrom Macroglobulinemia	3.3%
443	Multiple Myeloma	3.3%
444	Gastrointestinal Stromal Tumors	3.3%
445	Afibrinogenemia	3.3%
446	Dystonia Musculorum Deformans	3.3%
447	Factor VII Deficiency	3.3%
448	Factor X Deficiency	3.3%
449	Factor XII Deficiency	3.3%
450	Hemophilia A	3.3%
451	Activated Protein C Resistance	3.3%
452	Factor II deficiency	3.3%
453	Factor VIII Deficiency	3.3%
454	Factor V deficiency	3.3%
455	Factor XI Deficiency	3.3%
456	Hypoprothrombinemias	3.3%
457	Hemangioma, Cavernous	3.3%
458	Zellweger Syndrome	3.3%
459	Fanconi Anemia	3.3%
460	Leukemia, T-Cell	3.3%
461	Optic Atrophy, Hereditary, Leber	3.3%
462	Leukemia, B-Cell	3.3%
463	Lafora Disease	3.3%
464	Unverricht-Lundborg Syndrome	3.3%
465	Anemia, Diamond-Blackfan	3.3%
466	neurofibroma	3.3%
467	Lymphoma, Follicular	3.3%
468	T-Cell Lymphoma	3.3%
469	Mantle cell lymphoma	3.3%
470	Hyperphosphaturia	3.2%
471	Fibromatosis, Aggressive	3.1%
472	Fibromatosis, Abdominal	3.1%
473	Klatskin Tumor	3.1%
474	Cecal Neoplasms	3.1%
475	Duodenal Neoplasms	3.1%
476	Choroid Plexus Papilloma	3.1%
477	Turner Syndrome	3.1%
478	Mastocytoma	3%
479	Mastocytosis, Systemic	3%
480	Leukemia, Myeloid, Chronic-Phase	3%
481	Zollinger-Ellison syndrome	3%
482	Tonsillar Neoplasms	3%
483	Dermatitis, Atopic	3%
484	Cerebellar Neoplasms	3%
485	Graves Disease	3%
486	Xeroderma	3%
487	Mobius Syndrome	3%
488	Mucopolysaccharidosis III	2.9%
489	Polycystic Kidney, Autosomal Dominant	2.9%
490	Testicular Diseases	2.9%
491	Homocystinuria	2.9%
492	Nasopharyngeal Neoplasms	2.8%
493	Ovarian Diseases	2.8%
494	Leigh Disease	2.8%
495	Empty Sella Syndrome	2.8%
496	Hyperpituitarism	2.8%
497	Hypopituitarism	2.8%
498	Hypophysitis	2.8%
499	Classical Lissencephalies and Subcortical Band Heterotopias	2.8%
500	Colorectal Neoplasms	2.8%
501	Alkaptonuria	2.8%
502	Glycogen Storage Disease	2.8%
503	Hypophosphatasia	2.8%
504	Propionic acidemia	2.8%
505	Dihydropyrimidine Dehydrogenase Deficiency	2.8%
506	Cystinosis	2.8%
507	Hyperkeratosis, Epidermolytic	2.8%
508	Abdominal Cramps	2.8%
509	Abnormalities, Drug-Induced	2.8%
510	Amniotic Band Syndrome	2.8%
511	Asphyxia Neonatorum	2.8%
512	Infant, Premature, Diseases	2.8%
513	Situs Inversus	2.8%
514	Infantile Colic	2.8%
515	Behcet Syndrome	2.7%
516	Appendiceal Neoplasms	2.7%
517	Colonic Neoplasms	2.7%
518	Rectal Neoplasms	2.7%
519	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2.6%
520	Leukemia, Large Granular Lymphocytic	2.6%
521	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2.6%
522	Lymphoma, T-Cell, Cutaneous	2.6%
523	Lymphoma, AIDS-Related	2.6%
524	Enteropathy-Associated T-Cell Lymphoma	2.6%
525	Primary Effusion Lymphoma	2.6%
526	Paranasal Sinus Neoplasms	2.6%
527	Charcot-Marie-Tooth Disease	2.6%
528	Antley-Bixler Syndrome Phenotype	2.6%
529	Cryptorchidism	2.6%
530	Gaucher Disease	2.6%
531	Gestational Diabetes	2.5%
532	Latent Autoimmune Diabetes in Adults	2.5%
533	Diabetes Insipidus	2.5%
534	Diabetes Mellitus, Experimental	2.5%
535	Huntington Disease	2.5%
536	Eye Abnormalities	2.5%
537	Cardiovascular Abnormalities	2.5%
538	Hypolipoproteinemias	2.4%
539	Papillon-Lefevre Disease	2.4%
540	Hyperlipidemia, Familial Combined	2.4%
541	Hyperlipoproteinemia Type III	2.4%
542	Carbamoyl-Phosphate Synthase I Deficiency Disease	2.4%
543	Skin Abnormalities	2.4%
544	Lymphatic Abnormalities	2.4%
545	Congenital Microtia	2.4%
546	Anemia, Neonatal	2.4%
547	Persistent Fetal Circulation Syndrome	2.4%
548	Dupuytren Contracture	2.4%
549	Congenital diaphragmatic hernia	2.4%
550	Umbilical hernia	2.4%
551	Urticaria Pigmentosa	2.3%
552	Mycosis Fungoides	2.3%
553	Lymphomatoid Papulosis	2.3%
554	Plasmablastic lymphoma	2.3%
555	Hyperandrogenism	2.2%
556	Maxillary Sinus Neoplasms	2.2%
557	Anus Neoplasms	2.2%
558	Sigmoid Neoplasms	2.2%
559	Familial Periodic Paralysis	2.2%
560	Cushing Syndrome	2.2%
561	Hyperaldosteronism	2.2%
562	Hyperparathyroidism, Secondary	2.2%
563	Hypoaldosteronism	2.2%
564	Thyrotoxicosis	2.2%
565	Hyperparathyroidism, Primary	2.2%
566	Thyroid Hormone Resistance Syndrome	2.2%
567	Gonadal Dysgenesis	2.2%
568	Pituitary Apoplexy	2.2%
569	Adrenogenital Syndrome	2.2%
570	Ovotesticular Disorders of Sex Development	2.2%
571	Lactose Intolerance	2.2%
572	Variegate Porphyria	2.2%
573	Acute intermittent porphyria	2.2%
574	Porphyria Cutanea Tarda	2.2%
575	Diabetic Foot	2.2%
576	Tay-Sachs Disease	2.2%
577	Hyperhomocysteinemia	2.2%
578	Renal Aminoacidurias	2.2%
579	Fanconi Syndrome	2.2%
580	Pseudohypoaldosteronism	2.2%
581	Liddle Syndrome	2.2%
582	Hyperlipoproteinemia Type IV	2.2%
583	Hyperlipoproteinemia Type V	2.2%
584	Urogenital Abnormalities	2.2%
585	Niemann-Pick Disease, Type C	2.2%
586	Neonatal Abstinence Syndrome	2.1%
587	Burkitt Lymphoma	2.1%
588	Glycogen Storage Disease Type I	2.1%
589	Glycogen Storage Disease Type V	2.1%
590	Fetal Growth Retardation	2.1%
591	Fetal Hypoxia	2.1%
592	Congenital nystagmus	2.1%
593	Fetal Alcohol Spectrum Disorders	2.1%
594	Toxoplasmosis, Congenital	2.1%
595	Hydrops Fetalis	2.1%
596	Anencephaly	2.1%
597	Syphilis, Congenital	2.1%
598	Gout	2%
599	Pseudohypoparathyroidism	2%
600	Friedreich Ataxia	2%
601	Renal tubular acidosis	2%
602	Addison Disease	1.9%
603	Diabetic Angiopathies	1.9%
604	Autoimmune thyroiditis	1.9%
605	Primary Adrenal Insufficiency	1.9%
606	Diabetic Neuropathies	1.9%
607	Myxedema	1.9%
608	Orchitis	1.9%
609	Diabetic Amyotrophy	1.9%
610	Diabetic Autonomic Neuropathy	1.9%
611	Diabetic Cardiomyopathies	1.9%
612	Ovarian Hyperstimulation Syndrome	1.9%
613	Hyperprolactinemia	1.9%
614	Sezary Syndrome	1.9%
615	Radicular Cyst	1.9%
616	Congenital Hyperinsulinism	1.9%
617	Chorioamnionitis	1.8%
618	Maxillofacial Abnormalities	1.8%
619	Dural Arteriovenous Fistula	1.8%
620	Dextrocardia	1.8%
621	Hypoalphalipoproteinemias	1.8%
622	Familial Hypophosphatemic Rickets	1.7%
623	Abnormalities, Radiation-Induced	1.7%
624	Gigantism	1.7%
625	Prune Belly Syndrome	1.6%
626	Twins, Conjoined	1.6%
627	Waardenburg Syndrome	1.6%
628	Diabetic Nephropathy	1.6%
629	Acromegaly	1.6%
630	Hyperglycemic Hyperosmolar Nonketotic Coma	1.6%
631	Hashimoto Disease	1.6%
632	Anovulation	1.6%
633	Diabetic Ketoacidosis	1.6%
634	Oophoritis	1.6%
635	Hypokalemic periodic paralysis	1.6%
636	Glycosuria, Renal	1.6%
637	Cystinuria	1.6%
638	Scimitar Syndrome	1.5%
639	Ophthalmia Neonatorum	1.5%
640	Arthritis, Gouty	1.5%
641	Anophthalmos	1.4%
642	Anus, Imperforate	1.4%
643	Hydranencephaly	1.4%
644	Microphthalmos	1.4%
645	Neural Tube Defects	1.4%
646	Paralysis, Obstetric	1.4%
647	Retinopathy of Prematurity	1.4%
648	Tethered Cord Syndrome	1.4%
649	Iniencephaly	1.4%
650	Craniorachischisis	1.4%
651	Limb Deformities, Congenital	1.4%
652	Exencephaly	1.4%
653	Septo-Optic Dysplasia	1.4%
654	Craniofacial Abnormalities	1.4%
655	Cortical Dysplasia	1.4%
656	Malformations of Cortical Development	1.4%
657	Anorectal Malformations	1.4%
658	Bloom Syndrome	1.4%
659	Bronchopulmonary Dysplasia	1.4%
660	MELAS Syndrome	1.4%
661	Craniosynostosis	1.3%
662	Syndactyly	1.3%
663	Brachycephaly	1.3%
664	Acrocephalosyndactylia	1.3%
665	Microcephaly	1.3%
666	Macrocephaly	1.3%
667	Blepharophimosis	1.3%
668	Laryngostenosis	1.3%
669	Mouth Abnormalities	1.3%
670	Respiratory Distress Syndrome, Newborn	1.3%
671	Esophageal Atresia	1.3%
672	Intestinal Atresia	1.3%
673	Horseshoe Kidney	1.3%
674	Pectus excavatum	1.3%
675	Diabetic Retinopathy	1.2%
676	Klippel-Feil Syndrome	1.2%
677	Gastroschisis	1.2%
678	Synostosis	1.2%
679	Acrodermatitis	1.2%
680	Lymphangiectasis, Intestinal	1.2%
681	Gianotti-Crosti Syndrome	1.2%
682	Noonan Syndrome	1.2%
683	Arthrogryposis	1.1%
684	Choanal Atresia	1.1%
685	Tracheobronchomegaly	1.1%
686	Laryngocele	1.1%
687	Hypospadias	1.1%
688	Cleft Palate	1.1%
689	Dandy-Walker Syndrome	1.1%
690	Leukomalacia, Periventricular	1.1%
691	POEMS Syndrome	1.1%
692	Nesidioblastosis	1.1%
693	Porencephaly	1.1%
694	Jaw Abnormalities	1.1%
695	Laryngomalacia	1%
696	Pectus carinatum	1%
697	Bladder Exstrophy	1%
698	Epispadias	1%
699	Multicystic Dysplastic Kidney	1%
700	Poland Syndrome	1%
701	Amelia	0.9%
702	Arachnodactyly	0.9%
703	Ectopia Cordis	0.9%
704	Ectromelia	0.9%
705	Hemimelia	0.9%
706	Meningomyelocele	0.9%
707	Phocomelia	0.9%
708	Sirenomelia	0.9%
709	Spina Bifida	0.9%
710	Polydactyly	0.9%
711	Brachydactyly	0.9%
712	Plagiocephaly	0.9%
713	Lower Extremity Deformities, Congenital	0.9%
714	Upper Extremity Deformities, Congenital	0.9%
715	Single umbilical artery	0.9%
716	Waterhouse-Friderichsen Syndrome	0.9%
717	Kernicterus	0.9%
718	Aortic coarctation	0.8%
719	Cor Triatriatum	0.8%
720	Coronary Vessel Anomalies	0.8%
721	Dental Enamel Hypoplasia	0.8%
722	Patent ductus arteriosus	0.8%
723	Ebstein Anomaly	0.8%
724	Heart Septal Defects	0.8%
725	Hyaline Membrane Disease	0.8%
726	Hypodontia	0.8%
727	Macrostomia	0.8%
728	Meningocele	0.8%
729	Microstomia	0.8%
730	Tetralogy of Fallot	0.8%
731	Transposition of Great Vessels	0.8%
732	Hypoplastic Left Heart Syndrome	0.8%
733	May-Thurner Syndrome	0.8%
734	Encephalocele	0.8%
735	Craniofacial Dysostosis	0.8%
736	Wolff-Parkinson-White Syndrome	0.8%
737	Micrognathism	0.8%
738	Pierre Robin Syndrome	0.8%
739	Renal Osteodystrophy	0.8%
740	Renal rickets	0.8%
741	Retrognathia	0.7%
742	Long QT Syndrome	0.7%
743	Platybasia	0.7%
744	Tricuspid Atresia	0.7%
745	Arrhythmogenic Right Ventricular Dysplasia	0.7%
746	Bronchomalacia	0.7%
747	Tracheomalacia	0.7%
748	Dermal Sinus	0.7%
749	Spina Bifida Cystica	0.7%
750	Spina Bifida Occulta	0.7%
751	Lissencephaly	0.7%
752	Polymicrogyria	0.7%
753	Pachygyria	0.7%
754	Schizencephaly	0.7%
755	Periventricular Nodular Heterotopia	0.7%
756	Prognathism	0.7%
757	Aortopulmonary Septal Defect	0.6%
758	Double Outlet Right Ventricle	0.6%
759	Endocardial Cushion Defects	0.6%
760	Myocardial bridging	0.6%
761	Aorticopulmonary Septal Defect	0.6%
762	Mandibulofacial Dysostosis	0.5%
763	Romano-Ward Syndrome	0.5%
764	Truncus Arteriosus, Persistent	0.5%
765	Goldenhar Syndrome	0.5%
766	Talipes	0.5%
767	Arteriovenous fistula	0.4%
768	Congenital clubfoot	0.4%
769	Vertical Talus	0.4%

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