MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Osteitis Deformans

(UMLS:C0029401)

Definition:: A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.
UMLS ID:: C0029401
MeSH ID:: D010001

Classification:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.692

Synonym(s)

Osteitis Deformans

Bone Paget Disease

Bone Paget's Disease

Disease;Pagets (bone)

OSTEITIS DEFORMANS

Osseous Paget's Disease

Osteitis deformans

PAGET DISEASE

PAGET DISEASE BONE

10.

PAGET DISEASE, BONE

11.

PAGET'S BONE DISEASE

12.

PAGET'S DISEASE OF BONE

13.

PAGETS DISEASE OF BONE

14.

Paget disease of bone

15.

Paget's Disease

16.

Paget's Disease of Bone

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Teriparatide	FAERS: 31		US FAERS
2	Zoledronic Acid	FAERS: 17 Canada Vigilance: 5		Canada Vigilance OFFSIDES US FAERS
3	Alendronate	FAERS: 8		US FAERS
4	Pamidronate	FAERS: 4		US FAERS
5	Diclofenac	FAERS: 3		US FAERS
6	Carbamazepine	FAERS: 2		US FAERS
7	Raloxifene Hydrochloride	FAERS: 2		US FAERS
8	Rivastigmine	FAERS: 2		US FAERS
9	Sitagliptin Phosphate	FAERS: 2		US FAERS
10	Voriconazole	FAERS: 2		US FAERS
11	exemestane	FAERS: 2		OFFSIDES US FAERS
12	rofecoxib	FAERS: 2		US FAERS
13	CID 129626832	FAERS: 1		US FAERS
14	Citalopram	FAERS: 1		US FAERS
15	Dimethyl Fumarate	FAERS: 1		US FAERS
16	Docetaxel	FAERS: 1		OFFSIDES US FAERS
17	Estrogens, Conjugated (USP)	FAERS: 1		OFFSIDES US FAERS
18	Goserelin	FAERS: 1		US FAERS
19	Hydrochlorothiazide	FAERS: 1		US FAERS
20	Imatinib Mesylate	FAERS: 1		US FAERS
21	MDV 3100	FAERS: 1		US FAERS
22	Medroxyprogesterone Acetate	FAERS: 1		US FAERS
23	Rosiglitazone	FAERS: 1		US FAERS
24	Temozolomide	FAERS: 1		US FAERS
25	Valsartan	FAERS: 1		US FAERS
26	apremilast	FAERS: 1		US FAERS
27	palbociclib	FAERS: 1		US FAERS
28	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride			OFFSIDES
29	Allopurinol			OFFSIDES
30	Amantadine			OFFSIDES
31	Amoxicillin			OFFSIDES
32	Ampicillin			OFFSIDES
33	Atovaquone			OFFSIDES
34	Bisacodyl			OFFSIDES
35	Bupropion			OFFSIDES
36	Calcium Citrate			OFFSIDES
37	Carvedilol			OFFSIDES
38	Cefdinir			OFFSIDES
39	Cefoxitin			OFFSIDES
40	Ceftriaxone			OFFSIDES
41	Celecoxib			OFFSIDES
42	Chlorhexidine			OFFSIDES
43	Chlorpheniramine			OFFSIDES
44	Ciprofloxacin			OFFSIDES
45	Clindamycin			OFFSIDES
46	Cortisone			OFFSIDES
47	Cortisone			OFFSIDES
48	Dactinomycin		5101343	CTD
49	Diazepam			OFFSIDES
50	Diphenoxylate			OFFSIDES
51	Econazole			OFFSIDES
52	Ertapenem			OFFSIDES
53	Fluocinonide			OFFSIDES
54	Fluticasone-Salmeterol Drug Combination			OFFSIDES
55	Furosemide			OFFSIDES
56	Gabapentin			OFFSIDES
57	Hydroxyurea			OFFSIDES
58	Ibandronic Acid			OFFSIDES
59	Letrozole			OFFSIDES
60	Lidoderm			OFFSIDES
61	Linezolid			OFFSIDES
62	Lisinopril			OFFSIDES
63	Megestrol			OFFSIDES
64	Megestrol Acetate			OFFSIDES
65	Memantine			OFFSIDES
66	Meperidine			OFFSIDES
67	Mesalamine			OFFSIDES
68	Methotrexate			OFFSIDES
69	Modafinil			OFFSIDES
70	Moxifloxacin			OFFSIDES
71	Niacin			OFFSIDES
72	Omeprazole			OFFSIDES
73	Orphenadrine			OFFSIDES
74	Oxaprozin			OFFSIDES
75	Paclitaxel			OFFSIDES
76	Pamidronate		1632675	CTD OFFSIDES
77	Pergolide			OFFSIDES
78	Perphenazine			OFFSIDES
79	Pilocarpine			OFFSIDES
80	Pravastatin			OFFSIDES
81	Prednisone			OFFSIDES
82	Pregabalin			OFFSIDES
83	Raloxifene Hydrochloride			OFFSIDES
84	S 1108			OFFSIDES
85	Saridon			OFFSIDES
86	Scopolamine			OFFSIDES
87	Simvastatin			OFFSIDES
88	Tamoxifen			OFFSIDES
89	Tenofovir			OFFSIDES
90	Tenofovir			OFFSIDES
91	Tiotropium Bromide			OFFSIDES
92	Vinorelbine			OFFSIDES
93	Vitamin D			OFFSIDES
94	aliskiren			OFFSIDES
95	anagrelide			OFFSIDES
96	benazepril			OFFSIDES
97	carbidopa, levodopa drug combination			OFFSIDES
98	cefuroxime axetil			OFFSIDES
99	chlordiazepoxide, clidinium drug combination			OFFSIDES
100	chlorhexidine gluconate			OFFSIDES
101	efavirenz			OFFSIDES
102	salmon calcitonin		1933580	CTD
103	valdecoxib			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Bone Diseases, Developmental	42.9%
2	Hyperostosis	42.9%
3	Osteitis	42.9%
4	Osteochondrosis	42.9%
5	Spinal Diseases	42.9%
6	Osteoarthropathy, Secondary Hypertrophic	38.1%
7	Ainhum	31%
8	Dysostoses	31%
9	Spinal Stenosis	31%
10	Spondylosis	31%
11	Intervertebral Disc Degeneration	31%
12	Gigantism	30.5%
13	Spinal Neoplasms	30.5%
14	Spondylitis	30.5%
15	Bone Diseases, Endocrine	30%
16	Bone Diseases, Infectious	28.6%
17	Bone neoplasms	28.6%
18	Osteopenia	28.6%
19	Platybasia	28.2%
20	Osteochondritis	28.1%
21	Bone Resorption	27.9%
22	Aseptic Necrosis of Bone	27.9%
23	Chondrodysplasia Punctata	25.4%
24	Enchondromatosis	25.4%
25	Lordosis	25.4%
26	Osteosclerosis	25.4%
27	Spondylolysis	25.4%
28	kyphosis	25.4%
29	Kashin-Beck Disease	25.4%
30	Discitis	24.8%
31	Fasciitis	23.1%
32	Foot Deformities	23.1%
33	Arthropathy	23.1%
34	Melorheostosis	22.7%
35	Osteopetrosis	22.7%
36	Spondylolisthesis	22.7%
37	Pectus excavatum	22.4%
38	Multiple Epiphyseal Dysplasia	20.9%
39	Osteochondrodysplasias	20.9%
40	Osteomyelitis	20.5%
41	Osteoporosis	20.5%
42	Periostitis	20.5%
43	Bone Demineralization, Pathologic	20.5%
44	Post-Traumatic Osteoporosis	20.5%
45	Spondylarthropathies	20.4%
46	Alveolar Bone Loss	20.2%
47	Femur Head Necrosis	20.2%
48	Osteolysis	20.2%
49	Klippel-Feil Syndrome	19.7%
50	Synostosis	19.7%
51	Tuberculosis, Spinal	19.6%
52	Pectus carinatum	19.5%
53	Osteoarthritis, Spine	19.5%
54	Ankylosing spondylitis	19.2%
55	Contracture	19%
56	Fasciitis, Plantar	19%
57	Congenital Hypothyroidism	18.6%
58	Craniofacial Dysostosis	17.5%
59	Arthrogryposis	16.9%
60	Osteoporosis, Postmenopausal	16.7%
61	Dwarfism	16.4%
62	Jaw Diseases	15.8%
63	Arthritis, Psoriatic	15.3%
64	Acromegaly	15%
65	Joint Tuberculosis	15%
66	Tuberculosis, Osteoarticular	15%
67	Bone Tuberculosis	15%
68	Cartilage Diseases	15%
69	Foot Diseases	15%
70	Myopathy	15%
71	Rheumatism	15%
72	Chondromalacia	15%
73	Arthritis, Reactive	14.6%
74	Arthritis	14.3%
75	Bursitis	14.3%
76	Joint Instability	14.3%
77	Myofascial Pain Syndromes	14.3%
78	Rhabdomyolysis	14.3%
79	Synovitis	14.3%
80	Joint laxity	14.3%
81	Polyarthritis	14.3%
82	Frozen shoulder	14.3%
83	Patellofemoral Pain Syndrome	14.3%
84	Craniosynostosis	14%
85	Syndactyly	14%
86	Brachycephaly	14%
87	Fibromyalgia	14%
88	Polymyalgia Rheumatica	14%
89	Goldenhar Syndrome	14%
90	Metatarsalgia	13.9%
91	Hip Contracture	13.6%
92	Periarthritis	13.6%
93	Eosinophilic Granuloma	13.4%
94	Acrocephalosyndactylia	13.3%
95	Osteogenesis Imperfecta	12.8%
96	Mastoiditis	12.4%
97	Petrositis	12.4%
98	Osteoarthritis, Knee	12.4%
99	Poland Syndrome	12.3%
100	Mandibulofacial Dysostosis	12.2%
101	Ischemic contracture	12.2%
102	Rickets	12%
103	Rheumatic Fever	12%
104	Gout	11.2%
105	Temporomandibular Joint Disorders	11%
106	Talipes	10.9%
107	Antley-Bixler Syndrome Phenotype	10.7%
108	Bunion	10.3%
109	Fibrodysplasia Ossificans Progressiva	10.3%
110	Myoglobinuria	10.3%
111	Myositis Ossificans	10.3%
112	Tenosynovitis	10.3%
113	Sacroiliitis	10.3%
114	Temporomandibular Joint Dysfunction Syndrome	10.2%
115	Pseudohypoparathyroidism	10%
116	Osteomalacia	9.8%
117	Rheumatoid Arthritis	9.7%
118	Juvenile arthritis	9.7%
119	Compartment syndromes	9.5%
120	Maxillary Diseases	9.5%
121	Tendinitis	9.5%
122	Tendinopathy	9.5%
123	Hemarthrosis	9.3%
124	Myositis	9.3%
125	Tietze's Syndrome	9.3%
126	Limb Deformities, Congenital	9.3%
127	Isaacs syndrome	9.3%
128	Craniofacial Abnormalities	9.3%
129	Myotonic Disorders	9.3%
130	Congenital clubfoot	9.3%
131	Vertical Talus	9.3%
132	Palatal Neoplasms	9.2%
133	Rheumatoid Nodule	9.2%
134	Arthritis, Gouty	8.7%
135	Rubinstein-Taybi Syndrome	8.7%
136	Marfan Syndrome	7.7%
137	Basal Cell Nevus Syndrome	7.6%
138	Felty Syndrome	7.3%
139	Cockayne Syndrome	7.2%
140	Medial Tibial Stress Syndrome	7%
141	Arthritis, Infectious	7%
142	Mitochondrial Myopathies	6.9%
143	Muscle Cramp	6.8%
144	Eosinophilia-Myalgia Syndrome	6.8%
145	Gastroschisis	6.8%
146	Anterior Compartment Syndrome	6.8%
147	Enthesopathy	6.8%
148	Arthritis, Experimental	6.8%
149	Abdominal Compartment Syndrome	6.8%
150	Muscle Rigidity	6.8%
151	Muscle Spasticity	6.8%
152	Cogwheel Rigidity	6.8%
153	Nuchal Rigidity	6.8%
154	Amelia	6.7%
155	Arachnodactyly	6.7%
156	Ectromelia	6.7%
157	Hemimelia	6.7%
158	Phocomelia	6.7%
159	Sirenomelia	6.7%
160	Polymyositis	6.7%
161	Polydactyly	6.7%
162	Brachydactyly	6.7%
163	Plagiocephaly	6.7%
164	Lower Extremity Deformities, Congenital	6.7%
165	Upper Extremity Deformities, Congenital	6.7%
166	Nose Neoplasms	6.4%
167	Jaw Abnormalities	6.3%
168	Renal Osteodystrophy	6.1%
169	Renal rickets	6.1%
170	Rheumatoid Vasculitis	6.1%
171	Prognathism	6%
172	Chronic Fatigue Syndrome	5.8%
173	Nail-Patella Syndrome	5.6%
174	Giant Cell Epulis	5.5%
175	Muscle Weakness	5.5%
176	Musculoskeletal Pain	5.4%
177	Familial Periodic Paralysis	5.4%
178	Arthralgia	5.4%
179	Polyarthralgia	5.4%
180	Hip Dislocation	5.3%
181	Shoulder Dislocation	5.3%
182	Hip Dysplasia	5.3%
183	Sicca Syndrome	5.2%
184	Sjogren's Syndrome	5.2%
185	Muscular Dystrophy	5.1%
186	Orbital Myositis	5.1%
187	Dupuytren Contracture	5.1%
188	Pyomyositis	5%
189	Micrognathism	4.9%
190	Pierre Robin Syndrome	4.9%
191	Laryngomalacia	4.7%
192	Myotonic Dystrophy	4.6%
193	Myalgia	4.5%
194	Retrognathia	4.3%
195	Welander Distal Myopathy	4.1%
196	Maxillofacial Abnormalities	4.1%
197	Myotonia Congenita	4%
198	Bronchomalacia	4%
199	Tracheomalacia	4%
200	Microcephaly	4%
201	Macrocephaly	4%
202	Hypokalemic periodic paralysis	3.9%
203	Shoulder Pain	3.9%
204	Cleft Palate	3.4%
205	Dermatomyositis	3.4%
206	Muscular Dystrophy, Duchenne	3.3%
207	Familial Hypophosphatemic Rickets	3.3%
208	Mitochondrial Encephalomyopathies	3.3%
209	Porencephaly	3.3%
210	Noonan Syndrome	2.9%
211	Holoprosencephaly	2.5%
212	Radicular Cyst	2.4%
213	MELAS Syndrome	1.6%
214	Kearns-Sayre syndrome	1.5%

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