MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Mobius Syndrome

(UMLS:C0221060)

Definition:: A syndrome of congenital facial paralysis, frequently associated with abducens palsy and other congenital abnormalities including lingual palsy, clubfeet, brachial disorders, cognitive deficits, and pectoral muscle defects. Pathologic findings are variable and include brain stem nuclear aplasia, facial nerve aplasia, and facial muscle aplasia, consistent with a multifactorial etiology. (Adams et al., Principles of Neurology, 6th ed, p1020)
UMLS ID:: C0221060
MeSH ID:: D020331

Classification 1:

Name:

Stomatognathic Diseases
MeSH Tree Number(s):: C07.465.299.825

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.292.319.825

Classification 3:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.077.578|C16.614.595

Synonym(s)

Mobius Syndrome

CONGENITAL FACIAL DIPLEGIA SYNDROME

CONGENITAL NUCLEAR APLASIA

Charlie M. syndrome

Congenital facial diplegia

Facial-limb disruptive spectrum

Glossopalatine ankylosis syndrome

Hypoglossia-hypodactyly syndrome

MOBS - Moebius syndrome

10.

MOEBIUS SYNDROME

11.

Mobius syndrome

12.

Mobius' syndrome

13.

Moebius Syndrome

14.

Moebius congenital oculofacial paralysis

15.

Moebius sequence

16.

Moebius syndrome

17.

Moebius' anomalad

18.

Moebius' syndrome

19.

Moebius; congenital oculofacial paralysis

20.

M枚bius Syndrome

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Cocaine	8452605 15797189	CTD
2	Mifepristone	18460590	CTD
3	Misoprostol	View details 8368254 9637807 12806493 12815845 14745923 15797189 17054764 18460590 18516817 20933185	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Facial Hemiatrophy	35.9%
2	Melkersson-Rosenthal Syndrome	35.9%
3	Facial Neuralgia	31.5%
4	Bell Palsy	31.4%
5	Beckwith-Wiedemann Syndrome	29.8%
6	Wolf-Hirschhorn Syndrome	29.8%
7	Smith-Magenis syndrome	28.8%
8	Holoprosencephaly	28.5%
9	Cri-du-Chat Syndrome	27.2%
10	Down Syndrome	27.2%
11	Trisomy 21	27.2%
12	Facial Nerve Injuries	26.3%
13	Prader-Willi Syndrome	24.1%
14	Rubinstein-Taybi Syndrome	23.9%
15	Herpes Zoster Oticus	23.6%
16	Trigeminal Nerve Disorder	23.3%
17	CHARGE Syndrome	23.3%
18	Ectodermal Dysplasia	23.1%
19	Aplasia Cutis Congenita	23.1%
20	Prune Belly Syndrome	23%
21	Waardenburg Syndrome	23%
22	Aicardi's syndrome	21.7%
23	Mouth Abnormalities	20.6%
24	Abdominal Cramps	20.5%
25	Amniotic Band Syndrome	20.5%
26	Asphyxia Neonatorum	20.5%
27	Infant, Premature, Diseases	20.5%
28	Infantile Colic	20.5%
29	Nail-Patella Syndrome	20.5%
30	Xeroderma	20.3%
31	Cockayne Syndrome	19.4%
32	Trigeminal Neuralgia	19.3%
33	Alstrom Syndrome	19.1%
34	Cystic Fibrosis	19.1%
35	Bloom Syndrome	19.1%
36	Marfan Syndrome	19.1%
37	Congenital nystagmus	18.8%
38	Kartagener Syndrome	18.4%
39	Polycystic Kidney Diseases	18.3%
40	Abnormalities, Drug-Induced	17.8%
41	Situs Inversus	17.8%
42	Anencephaly	17.2%
43	Anemia, Neonatal	17%
44	Persistent Fetal Circulation Syndrome	17%
45	Umbilical hernia	16.9%
46	Meconium Aspiration Syndrome	16.8%
47	Smith-Lemli-Opitz Syndrome	16.5%
48	Ichthyosis, X-Linked	16.3%
49	Maxillofacial Abnormalities	16%
50	Dural Arteriovenous Fistula	16%
51	Primary Ciliary Dyskinesia	15.9%
52	Toxoplasmosis, Congenital	15.6%
53	Genetic Diseases, Inborn	15.5%
54	POEMS Syndrome	15.4%
55	Eye Abnormalities	15.3%
56	Cardiovascular Abnormalities	15.3%
57	Cleft Palate	15.2%
58	Skin Abnormalities	14.9%
59	Lymphatic Abnormalities	14.9%
60	Congenital Microtia	14.9%
61	Neonatal Abstinence Syndrome	14.9%
62	Fragile X Syndrome	14.8%
63	Congenital diaphragmatic hernia	14.7%
64	Macrostomia	14.4%
65	Microstomia	14.4%
66	Syphilis, Congenital	14.4%
67	Polycystic Kidney, Autosomal Dominant	14%
68	Hydranencephaly	13.6%
69	Neural Tube Defects	13.6%
70	Tethered Cord Syndrome	13.6%
71	Iniencephaly	13.6%
72	Craniorachischisis	13.6%
73	Exencephaly	13.6%
74	Septo-Optic Dysplasia	13.6%
75	Cortical Dysplasia	13.6%
76	Malformations of Cortical Development	13.6%
77	Sjogren-Larsson Syndrome	13.4%
78	Dextrocardia	13.4%
79	Classical Lissencephalies and Subcortical Band Heterotopias	13.3%
80	Urogenital Abnormalities	13.1%
81	Fetal Diseases	12.9%
82	Williams Syndrome	12.9%
83	Congenital Hyperinsulinism	12.7%
84	Dandy-Walker Syndrome	12.6%
85	Paralysis, Obstetric	12.5%
86	Retinopathy of Prematurity	12.5%
87	Hyperkeratosis, Epidermolytic	12.4%
88	Zellweger Syndrome	12.4%
89	Burning Mouth Syndrome	12.3%
90	Lip Diseases	12.3%
91	Microglossia	12.3%
92	Oral Submucous Fibrosis	12.3%
93	Periodontal Diseases	12.3%
94	Salivary Gland Diseases	12.3%
95	Stomatitis	12.3%
96	Tongue Diseases	12.3%
97	Oral Ulcer	12.3%
98	Vagus Nerve Disorder	12.3%
99	Glossopharyngeal Neuralgia	12.3%
100	Abducens Nerve Diseases	12.3%
101	Trochlear Nerve Diseases	12.3%
102	Bronchopulmonary Dysplasia	12.3%
103	Twins, Conjoined	12.2%
104	Ocular Motility Disorders	12.1%
105	Cyclophoria	12.1%
106	Jaw Abnormalities	12.1%
107	Microcephaly	12%
108	Macrocephaly	12%
109	Basal Cell Nevus Syndrome	12%
110	Central Nervous System Cysts	11.8%
111	Tuberous Sclerosis	11.8%
112	Leukomalacia, Periventricular	11.7%
113	Ophthalmoplegic Migraine	11.6%
114	Charcot-Marie-Tooth Disease	11.6%
115	Salivary Gland Fistula	11.5%
116	Salivary Gland Neoplasms	11.5%
117	Tongue Neoplasms	11.5%
118	Olfactory Nerve Injuries	11.3%
119	Parotid Neoplasms	11.1%
120	Acrocephalosyndactylia	11.1%
121	Porencephaly	11.1%
122	Scimitar Syndrome	10.9%
123	Turner Syndrome	10.9%
124	Refsum Disease	10.9%
125	Respiratory Distress Syndrome, Newborn	10.8%
126	Retinal Dysplasia	10.7%
127	Facial paralysis	10.6%
128	Facial Paresis	10.6%
129	Aniridia	10.6%
130	Optic Neuropathy	10.6%
131	Dental Enamel Hypoplasia	10.5%
132	Hypodontia	10.5%
133	Epidermolysis Bullosa	10.4%
134	Granulomatosis, Orofacial	10.3%
135	Craniosynostosis	10.3%
136	Syndactyly	10.3%
137	Brachycephaly	10.3%
138	Vestibulocochlear Nerve Diseases	10.2%
139	Anophthalmos	10.2%
140	Anus, Imperforate	10.2%
141	Oral candidiasis	10.2%
142	Microphthalmos	10.2%
143	Mouth Neoplasms	10.2%
144	Oral Fistula	10.2%
145	Tooth Loss	10.2%
146	Limb Deformities, Congenital	10.2%
147	Craniofacial Abnormalities	10.2%
148	Myasthenic Syndromes, Congenital	10.2%
149	Anorectal Malformations	10.2%
150	Retrognathia	10.2%
151	Lichen Planus, Oral	10.1%
152	Hemifacial Spasm	10.1%
153	Meningomyelocele	10.1%
154	Spina Bifida	10.1%
155	Gingival Hemorrhage	10%
156	Gingival Recession	10%
157	Parotitis	10%
158	Gingival Atrophy	10%
159	Ophthalmia Neonatorum	9.9%
160	Micrognathism	9.9%
161	Pierre Robin Syndrome	9.9%
162	Abnormalities, Radiation-Induced	9.7%
163	Duane Retraction Syndrome	9.4%
164	Noonan Syndrome	9.4%
165	Behcet Syndrome	9.4%
166	Muscular Dystrophy, Duchenne	9.4%
167	Prognathism	9.3%
168	Klinefelter Syndrome	9.2%
169	Nesidioblastosis	9.1%
170	Myotonic Dystrophy	8.9%
171	Blepharophimosis	8.8%
172	Laryngostenosis	8.8%
173	Mucopolysaccharidosis II	8.8%
174	Rett Syndrome	8.7%
175	Esophageal Atresia	8.7%
176	Intestinal Atresia	8.7%
177	Horseshoe Kidney	8.7%
178	Pectus excavatum	8.7%
179	Poland Syndrome	8.7%
180	Hepatolenticular Degeneration	8.7%
181	Klippel-Feil Syndrome	8.7%
182	Gastroschisis	8.7%
183	Synostosis	8.7%
184	Acrodermatitis	8.7%
185	Lymphangiectasis, Intestinal	8.7%
186	Gianotti-Crosti Syndrome	8.7%
187	Menkes Kinky Hair Syndrome	8.6%
188	Kallmann Syndrome	8.6%
189	Hyaline Membrane Disease	8.6%
190	Meningocele	8.6%
191	Encephalocele	8.6%
192	Adrenoleukodystrophy	8.6%
193	Pseudoxanthoma Elasticum	8.6%
194	Albinism	8.5%
195	Deformity	8.5%
196	Kernicterus	8.4%
197	Anemia, Sickle Cell	8.4%
198	Thalassemia	8.4%
199	Dystonia Musculorum Deformans	8.3%
200	Dermal Sinus	8.3%
201	Spina Bifida Cystica	8.3%
202	Spina Bifida Occulta	8.3%
203	Lissencephaly	8.3%
204	Polymicrogyria	8.3%
205	Pachygyria	8.3%
206	Schizencephaly	8.3%
207	Periventricular Nodular Heterotopia	8.3%
208	Neoplastic Syndromes, Hereditary	8.2%
209	Muscular Dystrophy	8.2%
210	Canavan Disease	8.1%
211	Alexander Disease	8.1%
212	Cheilitis	8.1%
213	Drooling	8.1%
214	Gingival Diseases	8.1%
215	Glossitis	8.1%
216	Macroglossia	8.1%
217	Periodontitis	8.1%
218	Sialadenitis	8.1%
219	Sialometaplasia, Necrotizing	8.1%
220	Sialorrhea	8.1%
221	Aphthous Stomatitis	8.1%
222	Xerostomia	8.1%
223	Glossoptosis	8.1%
224	Peri-Implantitis	8.1%
225	Antley-Bixler Syndrome Phenotype	8.1%
226	Multiple Epiphyseal Dysplasia	8%
227	Osteochondrodysplasias	8%
228	Pelger-Huet Anomaly	8%
229	Werner Syndrome	8%
230	Optic Atrophy, Hereditary, Leber	7.9%
231	Xeroderma Pigmentosum	7.9%
232	Amelia	7.8%
233	Arachnodactyly	7.8%
234	Ectopia Cordis	7.8%
235	Ectromelia	7.8%
236	Hemimelia	7.8%
237	Phocomelia	7.8%
238	Sirenomelia	7.8%
239	Polydactyly	7.8%
240	Brachydactyly	7.8%
241	Plagiocephaly	7.8%
242	Lower Extremity Deformities, Congenital	7.8%
243	Upper Extremity Deformities, Congenital	7.8%
244	Single umbilical artery	7.8%
245	Arthrogryposis	7.8%
246	Choanal Atresia	7.8%
247	Tracheobronchomegaly	7.8%
248	Laryngocele	7.8%
249	Neuronal Ceroid-Lipofuscinoses	7.7%
250	Choledochal Cyst	7.7%
251	Hermaphroditism	7.7%
252	Disorders of Sex Development	7.7%
253	Cryptorchidism	7.6%
254	Hypospadias	7.6%
255	Lafora Disease	7.5%
256	Unverricht-Lundborg Syndrome	7.5%
257	Ataxia Telangiectasia	7.5%
258	Amyloid Neuropathies, Familial	7.5%
259	Miller Fisher Syndrome	7.2%
260	Multiple System Atrophy	7.2%
261	Myotonia Congenita	7.1%
262	Demyelinating Diseases	7%
263	Demyelination	7%
264	Neuromuscular Diseases	7%
265	Tooth Diseases	7%
266	Chronobiology Disorders	7%
267	Opsoclonus-Myoclonus Syndrome	7%
268	Dwarfism	7%
269	Progressive supranuclear palsy	6.9%
270	Motor Neuron Disease	6.9%
271	Fabry Disease	6.9%
272	Laryngomalacia	6.9%
273	Stiff-Person Syndrome	6.8%
274	Optic Atrophy	6.8%
275	Optic Neuritis	6.8%
276	Papilledema	6.8%
277	Strabismus	6.8%
278	Tolosa-Hunt Syndrome	6.8%
279	Pectus carinatum	6.8%
280	Fetal Growth Retardation	6.8%
281	Huntington Disease	6.8%
282	Osteogenesis Imperfecta	6.8%
283	Fetal Hypoxia	6.8%
284	Fetal Alcohol Spectrum Disorders	6.8%
285	Familial Mediterranean Fever	6.8%
286	Ophthalmoplegia	6.8%
287	External Ophthalmoplegia	6.8%
288	Bladder Exstrophy	6.7%
289	Epispadias	6.7%
290	Dental Fistula	6.7%
291	Oroantral Fistula	6.7%
292	Vestibular Neuronitis	6.7%
293	Multicystic Dysplastic Kidney	6.7%
294	Aortic coarctation	6.7%
295	Cor Triatriatum	6.7%
296	Coronary Vessel Anomalies	6.7%
297	Patent ductus arteriosus	6.7%
298	Ebstein Anomaly	6.7%
299	Heart Septal Defects	6.7%
300	Tetralogy of Fallot	6.7%
301	Transposition of Great Vessels	6.7%
302	Hypoplastic Left Heart Syndrome	6.7%
303	May-Thurner Syndrome	6.7%
304	Craniofacial Dysostosis	6.7%
305	Wiskott-Aldrich Syndrome	6.7%
306	Wolff-Parkinson-White Syndrome	6.6%
307	Sickle Cell Trait	6.6%
308	Hyperandrogenism	6.5%
309	Restless Legs Syndrome	6.4%
310	Giant Cell Epulis	6.4%
311	Polyradiculoneuropathy	6.4%
312	Polyradiculoneuritis	6.4%
313	Neuromyelitis Optica	6.3%
314	Glycogen storage disease type II	6.3%
315	Acoustic Neuroma	6.1%
316	Galactosemias	6.1%
317	Urea Cycle Disorders, Inborn	6.1%
318	Tyrosinemias	6.1%
319	Friedreich Ataxia	6.1%
320	Gingivitis	6%
321	Glossitis, Benign Migratory	6%
322	Pericoronitis	6%
323	Aggressive Periodontitis	6%
324	Gingival Overgrowth	6%
325	Vocal Cord Paralysis	6%
326	Jaw Diseases	6%
327	Pharyngeal Diseases	6%
328	Trauma, Nervous System	6%
329	Subacute Combined Degeneration	6%
330	Autoimmune Lymphoproliferative Syndrome	6%
331	Amyotrophic Lateral Sclerosis	5.9%
332	Welander Distal Myopathy	5.9%
333	Vesicular Stomatitis	5.9%
334	Chorioamnionitis	5.9%
335	Nervous System Neoplasms	5.9%
336	Neurologic Manifestations	5.9%
337	Optic Neuropathy, Ischemic	5.9%
338	Neurotoxicity Syndromes	5.9%
339	Anterior Ischemic Optic Neuropathy	5.9%
340	Angioedemas, Hereditary	5.9%
341	Long QT Syndrome	5.9%
342	Platybasia	5.9%
343	Tricuspid Atresia	5.9%
344	Arrhythmogenic Right Ventricular Dysplasia	5.9%
345	Gonadal Dysgenesis	5.8%
346	Meningoencephalitis	5.8%
347	Bronchomalacia	5.8%
348	Adrenogenital Syndrome	5.8%
349	Tracheomalacia	5.8%
350	Ovotesticular Disorders of Sex Development	5.8%
351	Spinal Muscular Atrophy	5.8%
352	Progressive Muscular Atrophy	5.8%
353	Encephalomyelitis	5.7%
354	Prion Diseases	5.7%
355	Autonomic Dysreflexia	5.7%
356	Complex Regional Pain Syndromes	5.7%
357	Aortopulmonary Septal Defect	5.7%
358	Double Outlet Right Ventricle	5.7%
359	Endocardial Cushion Defects	5.7%
360	Myocardial bridging	5.7%
361	Aorticopulmonary Septal Defect	5.7%
362	Radicular Cyst	5.7%
363	Amino Acid Metabolism, Inborn Errors	5.6%
364	Carbohydrate Metabolism, Inborn Errors	5.6%
365	Metal Metabolism, Inborn Errors	5.6%
366	Progeria	5.6%
367	Lysosomal Storage Diseases	5.6%
368	Cytochrome-c Oxidase Deficiency	5.6%
369	Peroxisomal Disorders	5.6%
370	Parkinson Disease	5.5%
371	Optic Nerve Glioma	5.5%
372	Brain Diseases, Metabolic, Inborn	5.4%
373	Lewy Body Disease	5.4%
374	Guillain-Barre Syndrome	5.4%
375	Gaucher Disease	5.4%
376	Acute Chest Syndrome	5.4%
377	Palatal Neoplasms	5.3%
378	Homocystinuria	5.2%
379	Leigh Disease	5.2%
380	Striatonigral Degeneration	5.2%
381	Truncus Arteriosus, Persistent	5.2%
382	Goldenhar Syndrome	5.2%
383	Hydrops Fetalis	5.2%
384	Leukoencephalitis, Acute Hemorrhagic	5.1%
385	Sleep Wake Disorders	5.1%
386	Mucopolysaccharidosis III	5.1%
387	Mobius Syndrome	5.1%
388	Marchiafava-Bignami Disease	5.1%
389	Familial Periodic Paralysis	5%
390	Tay-Sachs Disease	5%
391	Alveolar Bone Loss	5%
392	Esotropia	5%
393	Exotropia	5%
394	Leukoplakia, Oral	5%
395	Pneumocephalus	5%
396	Poliomyelitis	5%
397	Gingival Hyperplasia	5%
398	Gingival Hypertrophy	5%
399	Spinal Cord Injuries	5%
400	Herpes Labialis	5%
401	Myelitis, Transverse	5%
402	Temporomandibular Joint Disorders	5%
403	Mandibulofacial Dysostosis	5%
404	Romano-Ward Syndrome	4.9%
405	Peripheral Nerve Injuries	4.9%
406	Cutis Laxa	4.9%
407	Myasthenia Gravis	4.9%
408	Asterixis	4.9%
409	Ballismus	4.9%
410	Retinitis Pigmentosa	4.8%
411	Pigmentary retinopathy	4.8%
412	Carbamoyl-Phosphate Synthase I Deficiency Disease	4.8%
413	Porokeratosis	4.8%
414	Keratoderma, Palmoplantar	4.8%
415	Chronic granulomatous disease	4.8%
416	Niemann-Pick Disease, Type C	4.8%
417	Hyperphosphaturia	4.8%
418	Causalgia	4.8%
419	Lambert-Eaton Myasthenic Syndrome	4.7%
420	Shy-Drager Syndrome	4.6%
421	Epidural Abscess	4.6%
422	Talipes	4.6%
423	Myelitis	4.5%
424	Progressive bulbar palsy	4.5%
425	Bulbar palsy	4.5%
426	MPTP Poisoning	4.5%
427	Alkaptonuria	4.4%
428	Glycogen Storage Disease	4.4%
429	Hypophosphatasia	4.4%
430	Propionic acidemia	4.4%
431	Dihydropyrimidine Dehydrogenase Deficiency	4.4%
432	Cystinosis	4.4%
433	Dyskinesia, Drug-Induced	4.4%
434	Chronic Fatigue Syndrome	4.4%
435	Encephalomyelitis, Acute Disseminated	4.4%
436	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	4.4%
437	Neuroleptic Malignant Syndrome	4.3%
438	Myelinolysis, Central Pontine	4.3%
439	Sleep Disorders, Circadian Rhythm	4.3%
440	Congenital clubfoot	4.3%
441	Vertical Talus	4.3%
442	Porphyrias, Hepatic	4.2%
443	Botulism	4.2%
444	Leukoencephalopathy, Progressive Multifocal	4.2%
445	Peutz-Jeghers Syndrome	4.2%
446	Thrombasthenia	4.2%
447	Antithrombin III Deficiency	4.2%
448	Protein C Deficiency	4.2%
449	Afibrinogenemia	4.2%
450	Factor VII Deficiency	4.2%
451	Factor X Deficiency	4.2%
452	Factor XII Deficiency	4.2%
453	Hemophilia A	4.2%
454	Activated Protein C Resistance	4.2%
455	Factor II deficiency	4.2%
456	Factor VIII Deficiency	4.2%
457	Factor V deficiency	4.2%
458	Factor XI Deficiency	4.2%
459	Hypoprothrombinemias	4.2%
460	Fanconi Anemia	4.1%
461	Mumps	4.1%
462	Hypokalemic periodic paralysis	4.1%
463	Anemia, Diamond-Blackfan	4.1%
464	Brain Diseases	4.1%
465	Bruxism	4.1%
466	Dental Leakage	4.1%
467	Dysautonomia	4.1%
468	Hypercementosis	4.1%
469	Malocclusion	4.1%
470	Meningitis	4.1%
471	Movement Disorders	4.1%
472	Pachymeningitis	4.1%
473	Spinal Cord Diseases	4.1%
474	Tooth Crowding	4.1%
475	Tooth Discoloration	4.1%
476	Tooth Demineralization	4.1%
477	Tooth Ankylosis	4.1%
478	Heavy Metal Poisoning, Nervous System	4.1%
479	Neuromuscular Junction Diseases	4.1%
480	Tauopathies	4.1%
481	Peripheral Nervous System Diseases	4.1%
482	Denys-Drash Syndrome	4.1%
483	Arteriovenous fistula	4%
484	Toxic Epidermal Necrolysis	4%
485	Stevens-Johnson Syndrome	4%
486	Reflex Sympathetic Dystrophy	3.9%
487	Subdural Effusion	3.9%
488	Parkinsonian Disorders	3.9%
489	Nocturnal Myoclonus Syndrome	3.9%
490	MELAS Syndrome	3.9%
491	Glycogen Storage Disease Type I	3.9%
492	Glycogen Storage Disease Type V	3.9%
493	Brain Injuries	3.8%
494	Sleep Bruxism	3.8%
495	Brain Neoplasms	3.8%
496	Multiple Sclerosis	3.8%
497	Spinal Cord Neoplasms	3.8%
498	Lupus Vasculitis, Central Nervous System	3.8%
499	Multiple Endocrine Neoplasia	3.8%
500	Hypolipoproteinemias	3.8%
501	Papillon-Lefevre Disease	3.8%
502	Hyperlipidemia, Familial Combined	3.8%
503	Hyperlipoproteinemia Type III	3.8%
504	Horner Syndrome	3.8%
505	Akathisia, Drug-Induced	3.8%
506	Congenital Hypothyroidism	3.7%
507	Dermatitis, Atopic	3.7%
508	Epilepsy, Post-Traumatic	3.7%
509	Limbic Encephalitis	3.7%
510	Myasthenia Gravis, Autoimmune, Experimental	3.6%
511	Ulcerative stomatitis	3.6%
512	Central Nervous System Infection	3.5%
513	Myopathy	3.5%
514	Tooth Injuries	3.5%
515	Craniocerebral Trauma	3.4%
516	Maxillary Diseases	3.4%
517	Parasomnia	3.4%
518	Tooth Resorption	3.4%
519	Dyssomnias	3.4%
520	Decerebrate State	3.4%
521	Hemiparesis	3.4%
522	Meningism	3.4%
523	Paresis	3.4%
524	Seizures	3.4%
525	Sensation Disorders	3.4%
526	Central Nervous System Neoplasms	3.4%
527	Complex partial seizures	3.4%
528	Monoparesis	3.4%
529	Neurogenic Inflammation	3.4%
530	Gait Disorders, Neurologic	3.4%
531	Neuromuscular Manifestations	3.4%
532	Sweating, Gustatory	3.4%
533	Auriculotemporal Syndrome	3.4%
534	Scrapie	3.4%
535	Central Cord Syndrome	3.4%
536	Toothache	3.4%
537	Brain Abscess	3.4%
538	Vasculitis, Central Nervous System	3.4%
539	Jet Lag Syndrome	3.4%
540	Dementia, Vascular	3.4%
541	Presenile dementia	3.3%
542	Senile dementia	3.3%
543	Meningitis, Bacterial	3.3%
544	Meningitis, Fungal	3.3%
545	Brain Hemorrhage, Traumatic	3.3%
546	Chorea	3.3%
547	Meige Syndrome	3.3%
548	Brachial Plexus Neuritis	3.3%
549	Neuralgic Amyotrophy	3.3%
550	Cerebral Ventriculitis	3.3%
551	Acrodynia	3.3%
552	Lactose Intolerance	3.3%
553	Variegate Porphyria	3.3%
554	Acute intermittent porphyria	3.3%
555	Porphyria Cutanea Tarda	3.3%
556	Hyperhomocysteinemia	3.3%
557	Renal Aminoacidurias	3.3%
558	Fanconi Syndrome	3.3%
559	Pseudohypoaldosteronism	3.3%
560	Liddle Syndrome	3.3%
561	Hypoalphalipoproteinemias	3.3%
562	Hyperlipoproteinemia Type IV	3.3%
563	Hyperlipoproteinemia Type V	3.3%
564	Cerebellar Neoplasms	3.3%
565	Tarsal Tunnel Syndrome	3%
566	Cauda Equina Syndrome	3%
567	Posterior Leukoencephalopathy Syndrome	3%
568	Posterior reversible encephalopathy syndrome	3%
569	Pupil Disorders	3%
570	Neurobehavioral Manifestations	3%
571	Sicca Syndrome	3%
572	Sjogren's Syndrome	3%
573	Gout	3%
574	Nasopharyngitis	3%
575	Brain Death	3%
576	Coma, Post-Head Injury	3%
577	Pharyngitis	3%
578	Carotid Artery Injuries	3%
579	Multiple Endocrine Neoplasia Type 1	3%
580	Pseudohypoparathyroidism	3%
581	Paraneoplastic Encephalomyelitis	2.9%
582	Amblyopia	2.9%
583	Renal tubular acidosis	2.9%
584	Paraneoplastic Cerebellar Degeneration	2.9%
585	Uveomeningoencephalitic Syndrome	2.9%
586	Kearns-Sayre syndrome	2.9%
587	Tuberculosis, Meningeal	2.9%
588	Cerebrospinal Fluid Otorrhea	2.9%
589	Cerebrospinal Fluid Rhinorrhea	2.9%
590	Neuritis, Autoimmune, Experimental	2.9%
591	Sturge-Weber Syndrome	2.9%
592	Vertigo	2.9%
593	Gait Ataxia	2.9%
594	Alcohol-Induced Disorders, Nervous System	2.9%
595	Cystinuria	2.9%
596	Creutzfeldt-Jakob disease	2.9%
597	Basal Ganglia Cerebrovascular Disease	2.9%
598	Brain Injuries, Diffuse	2.8%
599	Traumatic Brain Injury	2.8%
600	Cerebellar Ataxia	2.8%
601	Supratentorial Neoplasms	2.8%
602	Torticollis	2.8%
603	Multiple Sclerosis, Chronic Progressive	2.8%
604	Multiple Sclerosis, Relapsing-Remitting	2.8%
605	Temporomandibular Joint Dysfunction Syndrome	2.8%
606	Familial Hypophosphatemic Rickets	2.8%
607	Myoclonic Epilepsy	2.8%
608	Epilepsy, Temporal Lobe	2.8%
609	Epilepsy, Rolandic	2.8%
610	Benign Rolandic Epilepsy	2.8%
611	Nephroblastoma	2.8%
612	Alice in Wonderland Syndrome	2.7%
613	Akinetic Mutism	2.7%
614	Anoxic Encephalopathy	2.7%
615	Arachnoiditis	2.7%
616	Basal Ganglia Diseases	2.7%
617	Brain Damage, Chronic	2.7%
618	Cerebellar Diseases	2.7%
619	Dental caries	2.7%
620	Dental Plaque	2.7%
621	Dental Pulp Calcification	2.7%
622	Encephalitis	2.7%
623	Encephalomalacia	2.7%
624	Epilepsy	2.7%
625	Hydrocephalus	2.7%
626	Congenital Hydrocephalus	2.7%
627	Hypothalamic Diseases	2.7%
628	Aseptic Meningitis	2.7%
629	Neuritis	2.7%
630	Polyneuritis	2.7%
631	Pulpitis	2.7%
632	Radiculitis	2.7%
633	Syringomyelia	2.7%
634	Thalamic Diseases	2.7%
635	Tooth Erosion	2.7%
636	Intracranial Hypertension	2.7%
637	Polyneuropathy	2.7%
638	Mononeuritis	2.7%
639	Aura	2.7%
640	Leukoencephalopathy	2.7%
641	Essential Tremor	2.7%
642	Neuroaxonal Dystrophies	2.7%
643	Familial Tremor	2.7%
644	Headache Disorders	2.7%
645	Mononeuropathies	2.7%
646	Intracranial Hypotension	2.7%
647	Brachial Plexus Neuropathies	2.7%
648	Radiculopathy	2.7%
649	Mononeuropathy Multiplex	2.7%
650	Nerve Root Compression	2.7%
651	Brain Edema	2.7%
652	Brain Hypoxia	2.7%
653	Aqueductal Stenosis	2.7%
654	Pneumorrhachis	2.7%
655	Writer's Cramp	2.7%
656	Nasopharyngeal Neoplasms	2.7%
657	Alcohol Withdrawal Seizures	2.7%
658	Brain Concussion	2.6%
659	Pituitary Adenoma	2.6%
660	Pituitary Neoplasms	2.6%
661	Carpal Tunnel Syndrome	2.6%
662	Vascular Headaches	2.6%
663	neurofibroma	2.6%
664	Hypoxia-Ischemia, Brain	2.6%
665	Sciatica	2.6%
666	Tardive Dyskinesia	2.6%
667	Persistent Vegetative State	2.6%
668	Voice Disorders	2.6%
669	Voice Disturbance	2.6%
670	Akathisia	2.6%
671	Restlessness	2.6%
672	Psychomotor Agitation	2.6%
673	Pharyngeal Neoplasms	2.6%
674	Arthritis, Gouty	2.6%
675	Toxoplasmosis, Cerebral	2.5%
676	Adenomatous Polyposis Coli	2.5%
677	Juvenile Myoclonic Epilepsy	2.5%
678	Myoclonic Epilepsies, Progressive	2.5%
679	Vertebral Artery Dissection	2.4%
680	Amnesia, Transient Global	2.4%
681	Glycosuria, Renal	2.4%
682	Gait Apraxia	2.4%
683	Basal Ganglia Hemorrhage	2.4%
684	Cubital Tunnel Syndrome	2.4%
685	Diffuse Axonal Injury	2.4%
686	Brain Stem Neoplasms	2.4%
687	Meningitis, Cryptococcal	2.3%
688	Brain Diseases, Metabolic	2.3%
689	Cerebrovascular Disorders	2.3%
690	Myositis	2.3%
691	Tooth Avulsion	2.3%
692	Cerebrovascular Insufficiency	2.3%
693	Isaacs syndrome	2.3%
694	Arsenic Poisoning	2.3%
695	Dementia	2.3%
696	Myotonic Disorders	2.3%
697	Central Nervous System Fungal Infections	2.3%
698	Conus Medullaris Syndrome	2.3%
699	Spinal Cord Vascular Diseases	2.3%
700	Meningitis, Listeria	2.3%
701	Meningitis, Haemophilus	2.3%
702	Meningitis, Pneumococcal	2.3%
703	Frontotemporal dementia	2.3%
704	Dental Pulp Necrosis	2.2%
705	Diabetic Neuropathies	2.2%
706	Facial Injuries	2.2%
707	Diabetic Amyotrophy	2.2%
708	Diabetic Autonomic Neuropathy	2.2%
709	Sleep Talking	2.2%
710	Manganese Poisoning	2.2%
711	Sleep Disorders, Intrinsic	2.2%
712	Orthostatic intolerance	2.2%
713	Anosmia	2.2%
714	Ataxia	2.2%
715	Athetosis	2.2%
716	Catalepsy	2.2%
717	Dystonia	2.2%
718	Hemiplegia	2.2%
719	Locked-In Syndrome	2.2%
720	Meningeal Neoplasms	2.2%
721	Muscle Hypertonia	2.2%
722	Muscle hypotonia	2.2%
723	Myoclonus	2.2%
724	Myotonia	2.2%
725	Neuralgia	2.2%
726	Paraplegia	2.2%
727	Pseudobulbar Palsy	2.2%
728	Quadriplegia	2.2%
729	Spasm	2.2%
730	Spastic Paraplegia	2.2%
731	Status Epilepticus	2.2%
732	Taste Disorders	2.2%
733	Tremor	2.2%
734	Monoplegia	2.2%
735	Hypokinesia	2.2%
736	Paraparesis	2.2%
737	Bradykinesia	2.2%
738	Waxy flexibility	2.2%
739	Action Tremor	2.2%
740	Resting Tremor	2.2%
741	Dysosmia	2.2%
742	Quadriparesis	2.2%
743	Mercury Poisoning, Nervous System	2.2%
744	Olfaction Disorders	2.2%
745	Myokymia	2.2%
746	Lead Poisoning, Nervous System	2.2%
747	Somatosensory Disorders	2.2%
748	Neuropathic pain	2.2%
749	Hyperkinesia	2.2%
750	Intention tremor	2.2%
751	Reflex, Abnormal	2.2%
752	Hyporeflexia	2.2%
753	Hyperreflexia	2.2%
754	Subarachnoid Hemorrhage, Traumatic	2.2%
755	Carotid Artery, Internal, Dissection	2.2%
756	Mitochondrial Encephalomyopathies	2.2%
757	Subacute Sclerosing Panencephalitis	2.2%
758	Putaminal Hemorrhage	2.1%
759	Choroid Plexus Papilloma	2.1%
760	Infarction, Middle Cerebral Artery	2.1%
761	Infarction, Anterior Cerebral Artery	2.1%
762	Infarction, Posterior Cerebral Artery	2.1%
763	Pituitary Apoplexy	2.1%
764	Brain Contusion	2.1%
765	Brain Infarction	2.1%
766	Cerebral Palsy	2%
767	Epilepsies, Partial	2%
768	Epilepsy, Generalized	2%
769	Pseudotumor Cerebri	2%
770	Sciatic Neuropathy	2%
771	Hypertensive Encephalopathy	2%
772	Ulnar Neuropathies	2%
773	Lesion of Sciatic Nerve	2%
774	Simple Partial Seizures	2%
775	Epilepsy, Reflex	2%
776	Ulnar Neuritis	2%
777	Radial nerve compression	2%
778	Radial Tunnel Syndrome	2%
779	Peroneal Neuropathies	2%
780	Radial Neuropathy	2%
781	Median Neuropathy	2%
782	Sciatic Nerve Palsy	2%
783	Femoral Neuropathy	2%
784	Tibial Neuropathy	2%
785	Ulnar Nerve Palsy	2%
786	Postural Orthostatic Tachycardia Syndrome	2%
787	Radial nerve palsy	2%
788	Headache Disorders, Primary	2%
789	Headache Disorders, Secondary	2%
790	Medication overuse headache	2%
791	Hand-Arm Vibration Syndrome	2%
792	Lemierre Syndrome	2%
793	Auditory Perceptual Disorders	2%
794	Vision Disorders	2%
795	Metamorphopsia	2%
796	Visual Impairment	2%
797	Fibromyalgia	2%
798	Central Nervous System Bacterial Infections	2%
799	Medial Tibial Stress Syndrome	2%
800	Giant Cell Arteritis	1.9%
801	Temporal Arteritis	1.9%
802	Mitochondrial Myopathies	1.9%
803	Anisocoria	1.9%
804	Confusion	1.9%
805	Lethargy	1.9%
806	Memory Disorders	1.9%
807	Muscle Cramp	1.9%
808	Perceptual Disorders	1.9%
809	Psychomotor Disorders	1.9%
810	Tonic Pupil	1.9%
811	Eosinophilia-Myalgia Syndrome	1.9%
812	Anhedonia	1.9%
813	Disorientation	1.9%
814	Memory Loss	1.9%
815	Hemisensory Neglect	1.9%
816	Dysacusis	1.9%
817	Tonsillitis	1.9%
818	Muscular Atrophy	1.9%
819	Respiratory Paralysis	1.9%
820	Tetany	1.9%
821	Cerebral Infarction	1.8%
822	Brain Stem Infarctions	1.8%
823	Alexia	1.8%
824	Dyslexia	1.8%
825	West Nile Fever	1.8%
826	Nasopharyngeal carcinoma	1.8%
827	Moyamoya Disease	1.7%
828	Pituitary Diseases	1.7%
829	Lateral Medullary Syndrome	1.7%
830	Neurofibrosarcoma	1.7%
831	Hematoma, Subdural	1.7%
832	Hematoma, Epidural, Cranial	1.7%
833	Consciousness Disorders	1.7%
834	Mental Retardation	1.7%
835	Muscle Weakness	1.7%
836	Depressed Level of Consciousness	1.7%
837	Mental deficiency	1.7%
838	Intellectual Disability	1.7%
839	Thoracic Outlet Syndrome	1.7%
840	Catatonia	1.7%
841	Carotid Artery Diseases	1.7%
842	Brain Ischemia	1.7%
843	Hypotension, Orthostatic	1.7%
844	Sleep Apnea Syndromes	1.7%
845	Cerebrovascular accident	1.7%
846	Polymyositis	1.7%
847	Kluver-Bucy Syndrome	1.7%
848	Vasospasm, Intracranial	1.7%
849	Spinal Cord Ischemia	1.7%
850	Intracranial Arterial Diseases	1.7%
851	Post-Exercise Hypotension	1.7%
852	Aphonia	1.7%
853	Sleep Deprivation	1.7%
854	Retropharyngeal Abscess	1.7%
855	Dysphonia	1.7%
856	Polyradiculopathy	1.7%
857	Post-Traumatic Headache	1.7%
858	Tension Headache	1.7%
859	Epilepsy, Complex Partial	1.7%
860	Migraine Disorders	1.7%
861	Abdominal Migraine	1.7%
862	Status Migrainosus	1.7%
863	Cervicogenic Headache	1.7%
864	Hypopharyngeal Neoplasms	1.7%
865	Hypopharyngeal Cancer	1.7%
866	Disorders of Excessive Somnolence	1.7%
867	Sleep Initiation and Maintenance Disorders	1.7%
868	Night Terrors	1.7%
869	Somnambulism	1.7%
870	Transient Insomnia	1.7%
871	Sleep Paralysis	1.7%
872	Chronic Insomnia	1.7%
873	REM Sleep Behavior Disorder	1.7%
874	Hypersomnia	1.7%
875	Dysgeusia	1.7%
876	Formication	1.7%
877	Hyperalgesia	1.7%
878	Hyperesthesia	1.7%
879	Hypesthesia	1.7%
880	Language Disorders	1.7%
881	Numbness	1.7%
882	Paresthesia	1.7%
883	Paraparesis, Spastic	1.7%
884	Trismus	1.7%
885	Epilepsia Partialis Continua	1.7%
886	Hypogeusia	1.7%
887	Meningeal Carcinomatosis	1.7%
888	Brown-Sequard Syndrome	1.7%
889	Lockjaw	1.7%
890	Allodynia	1.7%
891	Lead Poisoning, Nervous System, Childhood	1.7%
892	Lead Poisoning, Nervous System, Adult	1.7%
893	Ageusia	1.7%
894	Tuberculosis, Central Nervous System	1.7%
895	Hematoma, Subdural, Intracranial	1.5%
896	Hematoma, Subdural, Chronic	1.5%
897	Hematoma, Subdural, Acute	1.5%
898	Cluster Headache	1.5%
899	Migraine with Aura	1.5%
900	Familial Hemiplegic Migraine	1.5%
901	Chronic Paroxysmal Hemicrania	1.5%
902	SUNCT Syndrome	1.5%
903	Paroxysmal Hemicrania	1.5%
904	Myalgia	1.5%
905	Eye Injuries	1.5%
906	Orbital Myositis	1.4%
907	Diplopia	1.4%
908	Muscle Rigidity	1.4%
909	Muscle Spasticity	1.4%
910	Scotoma	1.4%
911	Photophobia	1.4%
912	Cogwheel Rigidity	1.4%
913	Amaurosis	1.4%
914	Blindness	1.4%
915	Nuchal Rigidity	1.4%
916	Reye Syndrome	1.4%
917	Neuroaspergillosis	1.4%
918	Pyomyositis	1.4%
919	Intracranial Embolism and Thrombosis	1.4%
920	Hepatic Encephalopathy	1.4%
921	Agnosia	1.4%
922	Apraxias	1.4%
923	Hallucinations	1.4%
924	Hemianopsia	1.4%
925	Hyperacusis	1.4%
926	Tinnitus	1.4%
927	Visual Agnosia	1.4%
928	Anosognosia	1.4%
929	Wernicke-Korsakoff Syndrome	1.4%
930	Phonophobia	1.4%
931	Hearing Loss	1.4%
932	Sarcopenia	1.4%
933	Empty Sella Syndrome	1.4%
934	Hyperpituitarism	1.4%
935	Hypopituitarism	1.4%
936	Hypophysitis	1.4%
937	Cerebral Arterial Diseases	1.4%
938	Vertebrobasilar Insufficiency	1.4%
939	Anterior Spinal Artery Syndrome	1.4%
940	Basilar Artery Stenosis	1.4%
941	Vertebral Artery Stenosis	1.4%
942	Sleep Apnea, Obstructive	1.4%
943	Sleep Apnea, Central	1.4%
944	Intracranial Hemorrhage, Hypertensive	1.4%
945	Transient Cerebral Ischemia	1.4%
946	Narcolepsy	1.4%
947	Kleine-Levin Syndrome	1.4%
948	Agraphia	1.4%
949	Anomia	1.4%
950	Cluttering	1.4%
951	Language Development Disorders	1.4%
952	Speech Disorders	1.4%
953	Syncope	1.4%
954	Stupor	1.4%
955	Dysgraphia	1.4%
956	Presyncope	1.4%
957	Dyslalia	1.4%
958	Hoarseness	1.3%
959	Alcohol Withdrawal Delirium	1.3%
960	Pseudorabies	1.3%
961	Amnesia	1.3%
962	Delirium	1.3%
963	Dissociative Amnesia	1.3%
964	Color blindness	1.3%
965	Global Amnesia	1.3%
966	Hyperprolactinemia	1.3%
967	Meningioma	1.2%
968	Subclavian Steal Syndrome	1.2%
969	Pick Disease of the Brain	1.2%
970	Cataplexy	1.2%
971	Neurosyphilis	1.2%
972	Peritonsillar Abscess	1.2%
973	Aphasia	1.2%
974	Articulation Disorders	1.2%
975	Echolalia	1.2%
976	Stuttering	1.2%
977	Dysphasia	1.2%
978	Tonsillar Neoplasms	1.2%
979	Eye Burns	1.2%
980	Waterhouse-Friderichsen Syndrome	1.2%
981	Malaria, Cerebral	1.2%
982	Carotid Stenosis	1.2%
983	Intracranial Aneurysm	1.2%
984	Neurocysticercosis	1.2%
985	Amaurosis Fugax	1.2%
986	Blindness, Cortical	1.2%
987	Dyscalculia	1.2%
988	Intracranial Arteriosclerosis	1.2%
989	Cerebral Atherosclerosis	1.2%
990	Subarachnoid Hemorrhage	1.2%
991	Cerebral Arteriosclerosis	1.2%
992	Cerebral Hemorrhage	1.2%
993	Cerebral Thrombosis	1.2%
994	Intracranial Embolism	1.2%
995	Intracranial Thrombosis	1.2%
996	Deafness	1.2%
997	Hearing Loss, Sudden	1.2%
998	Gerstmann Syndrome	1.2%
999	Hearing Loss, Bilateral	1.2%
1000	Hearing Loss, High-Frequency	1.2%
1001	Hearing Loss, Mixed Conductive-Sensorineural	1.2%
1002	Prosopagnosia	1.2%
1003	Apraxia, Ideomotor	1.2%
1004	Charles Bonnet Syndrome	1.2%
1005	Hearing Loss, Unilateral	1.2%
1006	Complete Hearing Loss	1.2%
1007	Alien Hand Syndrome	1.2%
1008	Deaf Mutism	1.2%
1009	Dysarthria	1.2%
1010	Wernicke Encephalopathy	1.1%
1011	AIDS Dementia Complex	1.1%
1012	Phantom pain	1.1%
1013	Phantom Limb Pain	1.1%
1014	Lyme Neuroborreliosis	1.1%
1015	Mutism	1.1%
1016	Selective Mutism	1.1%
1017	Acromegaly	1.1%
1018	Cerebral Amyloid Angiopathy	1.1%
1019	Dermatomyositis	1.1%
1020	Sinus Thrombosis, Intracranial	1.1%
1021	Corneal Scar	1.1%
1022	Retrograde amnesia	1%
1023	Amnesia, Anterograde	1%
1024	Carotid Artery Thrombosis	1%
1025	Alexia, Pure	1%
1026	Cavernous Sinus Thrombosis	1%
1027	Sagittal Sinus Thrombosis	1%
1028	Corneal Perforation	0.9%
1029	Nelson Syndrome	0.9%
1030	Prolactinoma	0.8%
1031	Growth Hormone-Secreting Pituitary Adenoma	0.8%

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