MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Corneal Perforation

(UMLS:C0339293)

Definition:: A puncture or hole through the CORNEAL STROMA resulting from various diseases or trauma.
UMLS ID:: C0339293
MeSH ID:: D057112

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.900.300.284.250.124.500

Classification 2:

Name:

Eye Diseases
MeSH Tree Number(s):: C11.204.284.500|C11.297.374.500

Classification 3:

Name:

Wounds and Injuries
MeSH Tree Number(s):: C26.915.300.425.250.124.500

Synonym(s)

Corneal Perforation

CORNEAL PERFORATION

Cornea, Perforation Of

Corneal perforation

Corneal perforation, NOS

Perforating wound of cornea

Perforation Of Cornea

Perforation of Cornea

Perforation of cornea

10.

Perforation of cornea, NOS

11.

cornea; perforation

12.

perforation; cornea

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	proxymetacaine	FAERS: 7		US FAERS
2	Erlotinib Hydrochloride	FAERS: 6		OFFSIDES US FAERS
3	Indomethacin	FAERS: 6		US FAERS
4	nepafenac	FAERS: 4		US FAERS
5	Dexamethasone	FAERS: 3		US FAERS
6	MDV 3100	FAERS: 3		US FAERS
7	Moxifloxacin	FAERS: 3		US FAERS
8	Ofloxacin	FAERS: 3		US FAERS
9	Prednisolone	FAERS: 3		SIDER US FAERS
10	prednisolone acetate	FAERS: 3		OFFSIDES US FAERS
11	Colchicine	FAERS: 2		US FAERS
12	Gatifloxacin	FAERS: 2		OFFSIDES SIDER US FAERS
13	Lamotrigine	FAERS: 2		OFFSIDES US FAERS
14	Mycophenolic Acid	FAERS: 2		US FAERS
15	Natamycin	FAERS: 2		US FAERS
16	Phenytoin	FAERS: 2		US FAERS
17	eribulin	FAERS: 2		US FAERS
18	Acitretin	FAERS: 1		US FAERS
19	Acyclovir	FAERS: 1		US FAERS
20	Amoxicillin	FAERS: 1		US FAERS
21	Capecitabine	FAERS: 1		US FAERS
22	Ciloxan	FAERS: 1		US FAERS
23	Ciprofloxacin	FAERS: 1		US FAERS
24	Diclofenac	FAERS: 1		OFFSIDES SIDER US FAERS
25	Doxycycline	FAERS: 1		US FAERS
26	Duloxetine Hydrochloride	FAERS: 1		US FAERS
27	Mitomycin	FAERS: 1	1454338	CTD US FAERS
28	Moxifloxacin	FAERS: 1		US FAERS
29	Mycophenolic Acid	FAERS: 1		OFFSIDES US FAERS
30	Naproxen	FAERS: 1		US FAERS
31	Piroxicam	FAERS: 1		US FAERS
32	Ruxolitinib phosphate	FAERS: 1		US FAERS
33	Sorafenib	FAERS: 1		US FAERS
34	Sunitinib	FAERS: 1		US FAERS
35	Teriparatide	FAERS: 1		US FAERS
36	betamethasone sodium phosphate	FAERS: 1		US FAERS
37	chlorhexidine gluconate	FAERS: 1		US FAERS
38	dorzolamide	FAERS: 1		US FAERS
39	ponatinib	FAERS: 1		US FAERS
40	Amifostine			OFFSIDES
41	Dapsone			OFFSIDES
42	Erlotinib Hydrochloride			OFFSIDES SIDER
43	Erythromycin			OFFSIDES
44	Fluorometholone			OFFSIDES
45	Fosfomycin			OFFSIDES
46	Ketorolac			SIDER
47	Loteprednol Etabonate			OFFSIDES
48	Nevirapine			OFFSIDES
49	Olopatadine Hydrochloride			OFFSIDES
50	Rabeprazole			OFFSIDES
51	Vitamin D			OFFSIDES
52	bromfenac			SIDER
53	crotamiton			OFFSIDES
54	prednefrin			SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Eye Burns	23.7%
2	Iridocorneal endothelial syndrome	17.6%
3	Corneal edema	15.8%
4	Corneal Opacity	15.8%
5	Keratitis	15.8%
6	Keratoconus	15.8%
7	Corneal Neovascularization	15.8%
8	Brain Injuries	15.8%
9	Coma, Post-Head Injury	14.9%
10	Ocular Motility Disorders	14%
11	Cyclophoria	14%
12	Optic Neuropathy	13.8%
13	Asthenopia	13.6%
14	Conjunctival Diseases	13.6%
15	Eyelid Diseases	13.6%
16	Lacrimal Apparatus Diseases	13.6%
17	Lens Diseases	13.6%
18	Ocular Hypertension	13.6%
19	Ocular Hypotension	13.6%
20	Retinal Diseases	13.6%
21	Scleral Diseases	13.6%
22	Vitreous Detachment	13.6%
23	Posterior Vitreous Detachment	13.6%
24	Retinal Dysplasia	13.5%
25	Retinal Degeneration	13.4%
26	Peripheral Nerve Injuries	13.2%
27	Corneal Ulcer	13.2%
28	Corneal Endothelial Cell Loss	13.2%
29	Keratoconjunctivitis	13.1%
30	Keratoconjunctivitis Sicca	12.1%
31	Aniridia	11.9%
32	Pupil Disorders	11.8%
33	Trachoma	11.7%
34	Blepharophimosis	11.5%
35	Uveal Neoplasms	11.5%
36	Eyelid Neoplasms	11.4%
37	Retinal Hemorrhage	11.4%
38	Eye Abnormalities	11.4%
39	Eye Infection	11.4%
40	Eye Manifestations	11.4%
41	Eye Neoplasms	11.4%
42	Spinal Cord Injuries	11.3%
43	Xerophthalmia	11%
44	Low Tension Glaucoma	11%
45	Duane Retraction Syndrome	11%
46	Brain Hemorrhage, Traumatic	10.8%
47	Vision Disorders	10.7%
48	Metamorphopsia	10.7%
49	Visual Impairment	10.7%
50	Brain Concussion	10%
51	Acanthamoeba Keratitis	9.9%
52	Keratitis, Herpetic	9.9%
53	Eye Hemorrhage	9.6%
54	Choroid Hemorrhage	9.4%
55	Pneumocephalus	9.4%
56	Olfactory Nerve Injuries	9%
57	Color blindness	8.7%
58	Brain Injuries, Diffuse	8.7%
59	Traumatic Brain Injury	8.7%
60	Chorioretinitis	8.6%
61	Retinitis Pigmentosa	8.5%
62	Pigmentary retinopathy	8.5%
63	Retinoblastoma	8.3%
64	Hordeolum	8.2%
65	Epilepsy, Post-Traumatic	8.1%
66	Cerebrospinal Fluid Otorrhea	8%
67	Cerebrospinal Fluid Rhinorrhea	8%
68	Facial Nerve Injuries	8%
69	Angioid Streaks	7.9%
70	Anisometropia	7.9%
71	Aphakia	7.9%
72	Astigmatism	7.9%
73	Blepharitis	7.9%
74	Blepharoptosis	7.9%
75	Blepharospasm	7.9%
76	Choroid Diseases	7.9%
77	Conjunctivitis	7.9%
78	Dacryocystitis	7.9%
79	Dry Eye Syndromes	7.9%
80	Ectropion	7.9%
81	Enophthalmos	7.9%
82	Entropion	7.9%
83	Episcleritis	7.9%
84	Exophthalmos	7.9%
85	Glaucoma	7.9%
86	Iris Diseases	7.9%
87	Lacrimal Duct Obstruction	7.9%
88	Lens dislocation	7.9%
89	Lens Subluxation	7.9%
90	Mydriasis	7.9%
91	Myopia	7.9%
92	Presbyopia	7.9%
93	Pterygium	7.9%
94	Retinal Detachment	7.9%
95	Retinitis	7.9%
96	Scleritis	7.9%
97	Uveitis	7.9%
98	Orbital Pseudotumor	7.9%
99	Cataract	7.9%
100	Pinguecula	7.9%
101	Trichiasis	7.9%
102	Optic Atrophy	7.9%
103	Optic Neuritis	7.9%
104	Papilledema	7.9%
105	Strabismus	7.9%
106	Tolosa-Hunt Syndrome	7.9%
107	Pars Planitis	7.6%
108	Frostbite	7.1%
109	Choroiditis	7%
110	Iridocyclitis	7%
111	Iritis	7%
112	Ophthalmoplegia	6.8%
113	External Ophthalmoplegia	6.8%
114	Optic Neuropathy, Ischemic	6.8%
115	Anterior Ischemic Optic Neuropathy	6.8%
116	Corneal Diseases	6.8%
117	Anisocoria	6.7%
118	Tonic Pupil	6.7%
119	Anophthalmos	6.6%
120	Endophthalmitis	6.6%
121	Microphthalmos	6.6%
122	Pemphigoid, Benign Mucous Membrane	6.6%
123	Retinal Artery Occlusion	6.6%
124	Retinopathy of Prematurity	6.6%
125	Orbital Cellulitis	6.6%
126	Retinal Vasculitis	6.6%
127	Hypertensive Retinopathy	6.6%
128	Retrobulbar Hemorrhage	6.6%
129	Cytomegalovirus Retinitis	6.6%
130	Hyphema	6.6%
131	Retinal Neovascularization	6.6%
132	Vitreous Hemorrhage	6.6%
133	Bacterial conjunctivitis	6.5%
134	Amblyopia	6.4%
135	Orbital Myositis	6.2%
136	Diplopia	6.2%
137	Scotoma	6.2%
138	Photophobia	6.2%
139	Amaurosis	6.2%
140	Blindness	6.2%
141	Autonomic Dysreflexia	6.1%
142	Opsoclonus-Myoclonus Syndrome	6%
143	Ophthalmoplegic Migraine	5.8%
144	Hematoma, Subdural	5.8%
145	Hematoma, Epidural, Cranial	5.8%
146	Uveomeningoencephalitic Syndrome	5.8%
147	Central Cord Syndrome	5.8%
148	Retinal Vein Occlusion	5.7%
149	Diabetic Retinopathy	5.6%
150	Eye pain	5.6%
151	Athletic Injuries	5.6%
152	Cranial nerve diseases	5.6%
153	Demyelinating Diseases	5.6%
154	Demyelination	5.6%
155	Hand Injuries	5.6%
156	Neuromuscular Diseases	5.6%
157	Soft Tissue Injuries	5.6%
158	Sprain	5.6%
159	Sprains and Strains	5.6%
160	Tendon Injuries	5.6%
161	Laceration	5.6%
162	Wounds, Penetrating	5.6%
163	Heat Cramps	5.6%
164	Chronobiology Disorders	5.6%
165	Rupture	5.6%
166	Horner Syndrome	5.5%
167	Brain Contusion	5.4%
168	Subarachnoid Hemorrhage, Traumatic	5.4%
169	Miller Fisher Syndrome	5.4%
170	Panophthalmitis	5.3%
171	Angle Closure Glaucoma	5.2%
172	Glaucoma, Open-Angle	5.2%
173	Macular degeneration	5.2%
174	Panuveitis	5.2%
175	Retinal Drusen	5.2%
176	Retinal Necrosis Syndrome, Acute	5.2%
177	Retinoschisis	5.2%
178	Exfoliation Syndrome	5.2%
179	Diffuse Axonal Injury	5.2%
180	Vertebral Artery Dissection	5.1%
181	Esotropia	5%
182	Exotropia	5%
183	Corneal Scar	4.9%
184	Carotid Artery Injuries	4.9%
185	Progressive supranuclear palsy	4.8%
186	Eye Injuries	4.8%
187	Aicardi's syndrome	4.7%
188	Crush syndrome	4.7%
189	Femoral Fractures	4.7%
190	Tibial Fractures	4.7%
191	Motor Neuron Disease	4.7%
192	Optic Atrophy, Hereditary, Leber	4.7%
193	Bites and Stings	4.7%
194	Extravasation of Diagnostic and Therapeutic Materials	4.7%
195	Nervous System Neoplasms	4.7%
196	Neurologic Manifestations	4.7%
197	Vascular System Injuries	4.7%
198	Tympanic Membrane Perforation	4.7%
199	Neurotoxicity Syndromes	4.7%
200	Tooth Injuries	4.7%
201	Asphyxia	4.6%
202	Esophageal Perforation	4.6%
203	Shock, Traumatic	4.6%
204	Self Mutilation	4.6%
205	Stiff-Person Syndrome	4.5%
206	Neuromyelitis Optica	4.4%
207	Restless Legs Syndrome	4.4%
208	Congenital nystagmus	4.4%
209	Choroidal Neovascularization	4.3%
210	Hemianopsia	4.3%
211	Hip Fractures	4.1%
212	Multiple System Atrophy	4.1%
213	Sleep Wake Disorders	4.1%
214	Hip Dislocation	4.1%
215	Shoulder Dislocation	4.1%
216	Splenic Rupture	4.1%
217	Hip Dysplasia	4.1%
218	Polyradiculoneuropathy	4.1%
219	Polyradiculoneuritis	4.1%
220	Amaurosis Fugax	4%
221	Blindness, Cortical	4%
222	Drowning	4%
223	Subacute Combined Degeneration	4%
224	Ophthalmia Neonatorum	3.9%
225	Anterior uveitis	3.9%
226	Uveitis, Posterior	3.9%
227	CHARGE Syndrome	3.8%
228	Herpes Zoster Ophthalmicus	3.8%
229	Albinism	3.6%
230	Chilblains	3.6%
231	Encephalomyelitis	3.6%
232	Spinal Fractures	3.6%
233	Prion Diseases	3.6%
234	Complex Regional Pain Syndromes	3.6%
235	Conus Medullaris Syndrome	3.6%
236	Hematoma, Subdural, Intracranial	3.5%
237	Hematoma, Subdural, Chronic	3.5%
238	Hematoma, Subdural, Acute	3.5%
239	Radiation injury	3.4%
240	Graves Disease	3.3%
241	Amyotrophic Lateral Sclerosis	3.3%
242	Corneal Perforation	3.2%
243	Mandibulofacial Dysostosis	3.2%
244	Spinal Muscular Atrophy	3.2%
245	Progressive Muscular Atrophy	3.2%
246	Medial Tibial Stress Syndrome	3.1%
247	Myasthenia Gravis	3.1%
248	Asterixis	3.1%
249	Ballismus	3.1%
250	Alstrom Syndrome	3.1%
251	Kearns-Sayre syndrome	3%
252	Marchiafava-Bignami Disease	3%
253	Parkinson Disease	2.9%
254	Lambert-Eaton Myasthenic Syndrome	2.9%
255	Optic Nerve Glioma	2.9%
256	Meningoencephalitis	2.9%
257	Human Bite	2.8%
258	Brain Diseases	2.8%
259	Contusions	2.8%
260	Decompression Sickness	2.8%
261	Dysautonomia	2.8%
262	Finger Injuries	2.8%
263	Flail Chest	2.8%
264	Fractures, Closed	2.8%
265	Pathological fracture	2.8%
266	Heart Injuries	2.8%
267	Heat Exhaustion	2.8%
268	Heat Stroke	2.8%
269	Knee Injuries	2.8%
270	Meningitis	2.8%
271	Movement Disorders	2.8%
272	Pachymeningitis	2.8%
273	Spinal Cord Diseases	2.8%
274	Foot Injuries	2.8%
275	Vagus Nerve Disorder	2.8%
276	Decapitation	2.8%
277	Glossopharyngeal Neuralgia	2.8%
278	Ankle Fracture	2.8%
279	Abducens Nerve Diseases	2.8%
280	Avulsion fracture	2.8%
281	Compression fracture	2.8%
282	Osteoporotic Fractures	2.8%
283	Heavy Metal Poisoning, Nervous System	2.8%
284	Neuromuscular Junction Diseases	2.8%
285	Tauopathies	2.8%
286	Trochlear Nerve Diseases	2.8%
287	Peripheral Nervous System Diseases	2.8%
288	Chronic Fatigue Syndrome	2.8%
289	Dandy-Walker Syndrome	2.8%
290	Poliomyelitis	2.8%
291	Sleep Disorders, Circadian Rhythm	2.8%
292	Lewy Body Disease	2.7%
293	Guillain-Barre Syndrome	2.7%
294	Botulism	2.7%
295	Central Nervous System Cysts	2.7%
296	Sicca Syndrome	2.6%
297	Sjogren's Syndrome	2.6%
298	Neuroleptic Malignant Syndrome	2.6%
299	Myelinolysis, Central Pontine	2.6%
300	Dyskinesia, Drug-Induced	2.6%
301	Myelitis, Transverse	2.5%
302	Carotid Artery, Internal, Dissection	2.5%
303	Myelitis	2.5%
304	Progressive bulbar palsy	2.5%
305	Iliotibial Band Syndrome	2.5%
306	Bulbar palsy	2.5%
307	Central Nervous System Infection	2.4%
308	Myopathy	2.4%
309	Akathisia, Drug-Induced	2.4%
310	Facial Nerve Diseases	2.4%
311	Parasomnia	2.4%
312	Tendinitis	2.4%
313	Lung Injury	2.4%
314	Dyssomnias	2.4%
315	Tendinopathy	2.4%
316	Epidural Abscess	2.3%
317	Vestibulocochlear Nerve Diseases	2.3%
318	Decerebrate State	2.3%
319	Foreign-Body Reaction	2.3%
320	Hemiparesis	2.3%
321	Hydranencephaly	2.3%
322	Insect Bites and Stings	2.3%
323	Meningism	2.3%
324	Neural Tube Defects	2.3%
325	Paralysis, Obstetric	2.3%
326	Paresis	2.3%
327	Seizures	2.3%
328	Sensation Disorders	2.3%
329	Sunburn	2.3%
330	Tooth Avulsion	2.3%
331	Tethered Cord Syndrome	2.3%
332	Central Nervous System Neoplasms	2.3%
333	Complex partial seizures	2.3%
334	Iniencephaly	2.3%
335	Craniorachischisis	2.3%
336	Exencephaly	2.3%
337	Monoparesis	2.3%
338	Septo-Optic Dysplasia	2.3%
339	Cortical Dysplasia	2.3%
340	Neurogenic Inflammation	2.3%
341	Gait Disorders, Neurologic	2.3%
342	Neuromuscular Manifestations	2.3%
343	Malformations of Cortical Development	2.3%
344	Near Drowning	2.3%
345	Osteoradionecrosis	2.3%
346	Sweating, Gustatory	2.3%
347	Auriculotemporal Syndrome	2.3%
348	MPTP Poisoning	2.2%
349	Striatonigral Degeneration	2.2%
350	Leukoencephalitis, Acute Hemorrhagic	2.2%
351	Causalgia	2.2%
352	Encephalomyelitis, Acute Disseminated	2.1%
353	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	2.1%
354	Brain Neoplasms	2.1%
355	Multiple Sclerosis	2.1%
356	Spinal Cord Neoplasms	2.1%
357	Splenosis	2.1%
358	Neurobehavioral Manifestations	2.1%
359	Neoplasms, Radiation-Induced	2.1%
360	Paraneoplastic Encephalomyelitis	2%
361	Vasculitis, Central Nervous System	2%
362	Jet Lag Syndrome	2%
363	Sturge-Weber Syndrome	2%
364	Uterine Rupture	2%
365	Vertigo	2%
366	Alcohol-Induced Disorders, Nervous System	2%
367	Tuberous Sclerosis	2%
368	Shy-Drager Syndrome	2%
369	Carpal Tunnel Syndrome	2%
370	Dystonia Musculorum Deformans	1.9%
371	Leukoencephalopathy, Progressive Multifocal	1.9%
372	Reflex Sympathetic Dystrophy	1.9%
373	Subdural Effusion	1.9%
374	Parkinsonian Disorders	1.9%
375	Nocturnal Myoclonus Syndrome	1.9%
376	Myasthenia Gravis, Autoimmune, Experimental	1.9%
377	Brain Abscess	1.9%
378	Voice Disorders	1.8%
379	Voice Disturbance	1.8%
380	Cardiotoxicity	1.8%
381	Leukemia, Radiation-Induced	1.8%
382	Smith-Magenis syndrome	1.8%
383	Radiation Pneumonitis	1.8%
384	Dural Arteriovenous Fistula	1.8%
385	Radiation Fibrosis	1.8%
386	Aortic Rupture	1.7%
387	Limbic Encephalitis	1.7%
388	Vocal Cord Paralysis	1.7%
389	Scrapie	1.6%
390	Behcet Syndrome	1.6%
391	Huntington Disease	1.6%
392	Presenile dementia	1.6%
393	Senile dementia	1.6%
394	Meningitis, Bacterial	1.6%
395	Meningitis, Fungal	1.6%
396	Chorea	1.6%
397	Acrodynia	1.6%
398	Ataxia Telangiectasia	1.6%
399	Abnormalities, Radiation-Induced	1.6%
400	Canavan Disease	1.5%
401	Alexander Disease	1.5%
402	Reflex, Abnormal	1.5%
403	Hyporeflexia	1.5%
404	Hyperreflexia	1.5%
405	Radiation Injuries, Experimental	1.5%
406	Charcot-Marie-Tooth Disease	1.5%
407	Lupus Vasculitis, Central Nervous System	1.5%
408	Akinetic Mutism	1.5%
409	Anoxic Encephalopathy	1.5%
410	Arachnoiditis	1.5%
411	Basal Ganglia Diseases	1.5%
412	Brain Damage, Chronic	1.5%
413	Cerebellar Diseases	1.5%
414	Encephalitis	1.5%
415	Encephalomalacia	1.5%
416	Epilepsy	1.5%
417	Hydrocephalus	1.5%
418	Congenital Hydrocephalus	1.5%
419	Hypothalamic Diseases	1.5%
420	Aseptic Meningitis	1.5%
421	Neuritis	1.5%
422	Polyneuritis	1.5%
423	Pseudarthrosis	1.5%
424	Radiculitis	1.5%
425	Smoke Inhalation Injury	1.5%
426	Syringomyelia	1.5%
427	Thalamic Diseases	1.5%
428	Intracranial Hypertension	1.5%
429	Polyneuropathy	1.5%
430	Mononeuritis	1.5%
431	Aura	1.5%
432	Leukoencephalopathy	1.5%
433	Essential Tremor	1.5%
434	Neuroaxonal Dystrophies	1.5%
435	Familial Tremor	1.5%
436	Headache Disorders	1.5%
437	Mononeuropathies	1.5%
438	Intracranial Hypotension	1.5%
439	Alcohol Withdrawal Seizures	1.5%
440	Brachial Plexus Neuropathies	1.5%
441	Radiculopathy	1.5%
442	Mononeuropathy Multiplex	1.5%
443	Nerve Root Compression	1.5%
444	Brain Edema	1.5%
445	Brain Hypoxia	1.5%
446	Aqueductal Stenosis	1.5%
447	Pneumorrhachis	1.5%
448	Writer's Cramp	1.5%
449	Myotonia Congenita	1.4%
450	Paraneoplastic Cerebellar Degeneration	1.4%
451	Neuritis, Autoimmune, Experimental	1.4%
452	Gait Ataxia	1.4%
453	Hepatolenticular Degeneration	1.4%
454	Meige Syndrome	1.3%
455	Brachial Plexus Neuritis	1.3%
456	Neuralgic Amyotrophy	1.3%
457	Cerebral Ventriculitis	1.3%
458	Brain Death	1.3%
459	Cubital Tunnel Syndrome	1.3%
460	Akathisia	1.3%
461	Restlessness	1.3%
462	Psychomotor Agitation	1.3%
463	Myotonic Dystrophy	1.3%
464	Dementia, Vascular	1.2%
465	Brain Diseases, Metabolic	1.2%
466	Cerebrovascular Disorders	1.2%
467	Myositis	1.2%
468	Cerebrovascular Insufficiency	1.2%
469	Isaacs syndrome	1.2%
470	Arsenic Poisoning	1.2%
471	Dementia	1.2%
472	Myotonic Disorders	1.2%
473	Central Nervous System Fungal Infections	1.2%
474	Myasthenic Syndromes, Congenital	1.2%
475	Spinal Cord Vascular Diseases	1.2%
476	Diabetic Neuropathies	1.2%
477	Facial Neuralgia	1.2%
478	Granuloma, Foreign-Body	1.2%
479	Enthesopathy	1.2%
480	Diabetic Amyotrophy	1.2%
481	Diabetic Autonomic Neuropathy	1.2%
482	Sleep Talking	1.2%
483	Manganese Poisoning	1.2%
484	Sleep Disorders, Intrinsic	1.2%
485	Orthostatic intolerance	1.2%
486	Anosmia	1.2%
487	Ataxia	1.2%
488	Athetosis	1.2%
489	Catalepsy	1.2%
490	Dystonia	1.2%
491	Hemiplegia	1.2%
492	Locked-In Syndrome	1.2%
493	Meningeal Neoplasms	1.2%
494	Meningomyelocele	1.2%
495	Muscle Hypertonia	1.2%
496	Muscle hypotonia	1.2%
497	Myoclonus	1.2%
498	Myotonia	1.2%
499	Neuralgia	1.2%
500	Paraplegia	1.2%
501	Pseudobulbar Palsy	1.2%
502	Quadriplegia	1.2%
503	Spasm	1.2%
504	Spastic Paraplegia	1.2%
505	Status Epilepticus	1.2%
506	Taste Disorders	1.2%
507	Tremor	1.2%
508	Spina Bifida	1.2%
509	Monoplegia	1.2%
510	Hypokinesia	1.2%
511	Paraparesis	1.2%
512	Bradykinesia	1.2%
513	Waxy flexibility	1.2%
514	Action Tremor	1.2%
515	Resting Tremor	1.2%
516	Dysosmia	1.2%
517	Quadriparesis	1.2%
518	Mercury Poisoning, Nervous System	1.2%
519	Olfaction Disorders	1.2%
520	Myokymia	1.2%
521	Lead Poisoning, Nervous System	1.2%
522	Vestibular Neuronitis	1.2%
523	Somatosensory Disorders	1.2%
524	Neuropathic pain	1.2%
525	Hyperkinesia	1.2%
526	Intention tremor	1.2%
527	Uterine Perforation	1.2%
528	Lafora Disease	1.2%
529	Unverricht-Lundborg Syndrome	1.2%
530	Friedreich Ataxia	1.2%
531	Creutzfeldt-Jakob disease	1.2%
532	Basal Ganglia Cerebrovascular Disease	1.2%
533	Cerebellar Ataxia	1.2%
534	Supratentorial Neoplasms	1.2%
535	Torticollis	1.2%
536	Multiple Sclerosis, Chronic Progressive	1.2%
537	Multiple Sclerosis, Relapsing-Remitting	1.2%
538	Acoustic Neuroma	1.1%
539	Cerebellar Neoplasms	1.1%
540	Hand-Arm Vibration Syndrome	1.1%
541	Amnesia, Transient Global	1.1%
542	Refsum Disease	1.1%
543	Gait Apraxia	1.1%
544	Tarsal Tunnel Syndrome	1.1%
545	Cauda Equina Syndrome	1.1%
546	Posterior Leukoencephalopathy Syndrome	1.1%
547	Posterior reversible encephalopathy syndrome	1.1%
548	Fibromyalgia	1.1%
549	Central Nervous System Bacterial Infections	1.1%
550	Facial Hemiatrophy	1.1%
551	Melkersson-Rosenthal Syndrome	1.1%
552	Mitochondrial Myopathies	1.1%
553	Confusion	1.1%
554	Facial paralysis	1.1%
555	Lethargy	1.1%
556	Memory Disorders	1.1%
557	Muscle Cramp	1.1%
558	Perceptual Disorders	1.1%
559	Psychomotor Disorders	1.1%
560	Eosinophilia-Myalgia Syndrome	1.1%
561	Anhedonia	1.1%
562	Disorientation	1.1%
563	Facial Paresis	1.1%
564	Memory Loss	1.1%
565	Hemisensory Neglect	1.1%
566	Dysacusis	1.1%
567	Sleep Bruxism	1.1%
568	Anencephaly	1%
569	Meningocele	1%
570	Muscular Atrophy	1%
571	Respiratory Paralysis	1%
572	Encephalocele	1%
573	Tetany	1%
574	Amyloid Neuropathies, Familial	1%
575	Leukomalacia, Periventricular	1%
576	Tuberculosis, Meningeal	1%
577	Alice in Wonderland Syndrome	1%
578	Toxoplasmosis, Cerebral	1%
579	Consciousness Disorders	0.9%
580	Mental Retardation	0.9%
581	Muscle Weakness	0.9%
582	Depressed Level of Consciousness	0.9%
583	Mental deficiency	0.9%
584	Intellectual Disability	0.9%
585	Mobius Syndrome	0.9%
586	Bell Palsy	0.9%
587	Catatonia	0.9%
588	Herpes Zoster Oticus	0.9%
589	Vascular Headaches	0.9%
590	Familial Periodic Paralysis	0.9%
591	neurofibroma	0.9%
592	Hypoxia-Ischemia, Brain	0.9%
593	Aphonia	0.9%
594	Sleep Deprivation	0.9%
595	Dysphonia	0.9%
596	Sciatica	0.9%
597	Tardive Dyskinesia	0.9%
598	Persistent Vegetative State	0.9%
599	Mitochondrial Encephalomyopathies	0.9%
600	Giant Cell Arteritis	0.9%
601	Temporal Arteritis	0.9%
602	Myalgia	0.8%
603	Auditory Perceptual Disorders	0.8%
604	Neuronal Ceroid-Lipofuscinoses	0.8%
605	Meningitis, Cryptococcal	0.8%
606	Cerebral Palsy	0.8%
607	Epilepsies, Partial	0.8%
608	Epilepsy, Generalized	0.8%
609	Pseudotumor Cerebri	0.8%
610	Sciatic Neuropathy	0.8%
611	Hypertensive Encephalopathy	0.8%
612	Ulnar Neuropathies	0.8%
613	Lesion of Sciatic Nerve	0.8%
614	Simple Partial Seizures	0.8%
615	Epilepsy, Reflex	0.8%
616	Ulnar Neuritis	0.8%
617	Radial nerve compression	0.8%
618	Radial Tunnel Syndrome	0.8%
619	Peroneal Neuropathies	0.8%
620	Radial Neuropathy	0.8%
621	Median Neuropathy	0.8%
622	Sciatic Nerve Palsy	0.8%
623	Femoral Neuropathy	0.8%
624	Tibial Neuropathy	0.8%
625	Ulnar Nerve Palsy	0.8%
626	Postural Orthostatic Tachycardia Syndrome	0.8%
627	Radial nerve palsy	0.8%
628	Headache Disorders, Primary	0.8%
629	Headache Disorders, Secondary	0.8%
630	Medication overuse headache	0.8%
631	Meningitis, Listeria	0.8%
632	Meningitis, Haemophilus	0.8%
633	Meningitis, Pneumococcal	0.8%
634	Adrenoleukodystrophy	0.8%
635	Frontotemporal dementia	0.8%
636	Myoclonic Epilepsy	0.8%
637	Epilepsy, Temporal Lobe	0.8%
638	Epilepsy, Rolandic	0.8%
639	Benign Rolandic Epilepsy	0.8%
640	Hoarseness	0.7%
641	Cockayne Syndrome	0.7%
642	Alcohol Withdrawal Delirium	0.7%
643	Classical Lissencephalies and Subcortical Band Heterotopias	0.7%
644	Pituitary Diseases	0.7%
645	Brain Stem Neoplasms	0.7%
646	Thoracic Outlet Syndrome	0.7%
647	Pituitary Adenoma	0.7%
648	Pituitary Neoplasms	0.7%
649	Carotid Artery Diseases	0.7%
650	Brain Ischemia	0.7%
651	Hypotension, Orthostatic	0.7%
652	Sleep Apnea Syndromes	0.7%
653	Cerebrovascular accident	0.7%
654	Polymyositis	0.7%
655	Kluver-Bucy Syndrome	0.7%
656	Vasospasm, Intracranial	0.7%
657	Spinal Cord Ischemia	0.7%
658	Intracranial Arterial Diseases	0.7%
659	Post-Exercise Hypotension	0.7%
660	Disorders of Excessive Somnolence	0.7%
661	Sleep Initiation and Maintenance Disorders	0.7%
662	Night Terrors	0.7%
663	Somnambulism	0.7%
664	Trigeminal Nerve Disorder	0.7%
665	Transient Insomnia	0.7%
666	Sleep Paralysis	0.7%
667	Chronic Insomnia	0.7%
668	REM Sleep Behavior Disorder	0.7%
669	Hypersomnia	0.7%
670	Dermal Sinus	0.7%
671	Dysgeusia	0.7%
672	Formication	0.7%
673	Hyperalgesia	0.7%
674	Hyperesthesia	0.7%
675	Hypesthesia	0.7%
676	Language Disorders	0.7%
677	Numbness	0.7%
678	Paresthesia	0.7%
679	Paraparesis, Spastic	0.7%
680	Spina Bifida Cystica	0.7%
681	Trismus	0.7%
682	Spina Bifida Occulta	0.7%
683	Epilepsia Partialis Continua	0.7%
684	Hypogeusia	0.7%
685	Meningeal Carcinomatosis	0.7%
686	Brown-Sequard Syndrome	0.7%
687	Lissencephaly	0.7%
688	Polymicrogyria	0.7%
689	Pachygyria	0.7%
690	Schizencephaly	0.7%
691	Lockjaw	0.7%
692	Allodynia	0.7%
693	Lead Poisoning, Nervous System, Childhood	0.7%
694	Lead Poisoning, Nervous System, Adult	0.7%
695	Periventricular Nodular Heterotopia	0.7%
696	Ageusia	0.7%
697	Tuberculosis, Central Nervous System	0.7%
698	Holoprosencephaly	0.7%
699	Basal Ganglia Hemorrhage	0.6%
700	Pituitary Apoplexy	0.6%
701	Brain Infarction	0.6%
702	Subacute Sclerosing Panencephalitis	0.6%
703	Muscular Dystrophy	0.6%
704	Muscle Rigidity	0.6%
705	Muscle Spasticity	0.6%
706	Cogwheel Rigidity	0.6%
707	Hemifacial Spasm	0.6%
708	Nuchal Rigidity	0.6%
709	Reye Syndrome	0.6%
710	Neuroaspergillosis	0.6%
711	Pyomyositis	0.6%
712	Intracranial Embolism and Thrombosis	0.6%
713	Hepatic Encephalopathy	0.6%
714	Agnosia	0.6%
715	Apraxias	0.6%
716	Hallucinations	0.6%
717	Hyperacusis	0.6%
718	Tinnitus	0.6%
719	Visual Agnosia	0.6%
720	Anosognosia	0.6%
721	Wernicke-Korsakoff Syndrome	0.6%
722	Phonophobia	0.6%
723	Hearing Loss	0.6%
724	Sarcopenia	0.6%
725	MELAS Syndrome	0.6%
726	Alexia	0.5%
727	Dyslexia	0.5%
728	Juvenile Myoclonic Epilepsy	0.5%
729	Myoclonic Epilepsies, Progressive	0.5%
730	Pseudorabies	0.5%
731	Amnesia	0.5%
732	Delirium	0.5%
733	Dissociative Amnesia	0.5%
734	Global Amnesia	0.5%
735	Cri-du-Chat Syndrome	0.5%
736	Down Syndrome	0.5%
737	Brain Diseases, Metabolic, Inborn	0.5%
738	Trisomy 21	0.5%
739	POEMS Syndrome	0.5%
740	Meningioma	0.5%
741	Williams Syndrome	0.5%
742	Microcephaly	0.5%
743	Macrocephaly	0.5%
744	Neurosyphilis	0.5%
745	Hypokalemic periodic paralysis	0.5%
746	Porencephaly	0.5%
747	Polyradiculopathy	0.5%
748	Post-Traumatic Headache	0.5%
749	Tension Headache	0.5%
750	Epilepsy, Complex Partial	0.5%
751	Migraine Disorders	0.5%
752	Abdominal Migraine	0.5%
753	Status Migrainosus	0.5%
754	Cervicogenic Headache	0.5%
755	Choroid Plexus Papilloma	0.5%
756	Prader-Willi Syndrome	0.5%
757	Wernicke Encephalopathy	0.5%
758	AIDS Dementia Complex	0.5%
759	Phantom pain	0.4%
760	Phantom Limb Pain	0.4%
761	Lyme Neuroborreliosis	0.4%
762	Moyamoya Disease	0.4%
763	Neurofibrosarcoma	0.4%
764	Putaminal Hemorrhage	0.4%
765	Kernicterus	0.4%
766	Empty Sella Syndrome	0.4%
767	Hyperpituitarism	0.4%
768	Hypopituitarism	0.4%
769	Hypophysitis	0.4%
770	Cerebral Arterial Diseases	0.4%
771	Vertebrobasilar Insufficiency	0.4%
772	Anterior Spinal Artery Syndrome	0.4%
773	Basilar Artery Stenosis	0.4%
774	Vertebral Artery Stenosis	0.4%
775	Sleep Apnea, Obstructive	0.4%
776	Sleep Apnea, Central	0.4%
777	Intracranial Hemorrhage, Hypertensive	0.4%
778	Transient Cerebral Ischemia	0.4%
779	Narcolepsy	0.4%
780	Trigeminal Neuralgia	0.4%
781	Kleine-Levin Syndrome	0.4%
782	Agraphia	0.4%
783	Anomia	0.4%
784	Cluttering	0.4%
785	Language Development Disorders	0.4%
786	Speech Disorders	0.4%
787	Syncope	0.4%
788	Stupor	0.4%
789	Dysgraphia	0.4%
790	Presyncope	0.4%
791	Dyslalia	0.4%
792	Cerebral Infarction	0.4%
793	Brain Stem Infarctions	0.4%
794	Infarction, Middle Cerebral Artery	0.4%
795	Infarction, Anterior Cerebral Artery	0.4%
796	Infarction, Posterior Cerebral Artery	0.4%
797	Rubinstein-Taybi Syndrome	0.4%
798	West Nile Fever	0.4%
799	Toxoplasmosis, Congenital	0.4%
800	Malaria, Cerebral	0.3%
801	Carotid Stenosis	0.3%
802	Intracranial Aneurysm	0.3%
803	Welander Distal Myopathy	0.3%
804	Neurocysticercosis	0.3%
805	Menkes Kinky Hair Syndrome	0.3%
806	Dyscalculia	0.3%
807	Intracranial Arteriosclerosis	0.3%
808	Cerebral Atherosclerosis	0.3%
809	Rett Syndrome	0.3%
810	Subarachnoid Hemorrhage	0.3%
811	Cerebral Arteriosclerosis	0.3%
812	Cerebral Hemorrhage	0.3%
813	Cerebral Thrombosis	0.3%
814	Intracranial Embolism	0.3%
815	Intracranial Thrombosis	0.3%
816	Deafness	0.3%
817	Hearing Loss, Sudden	0.3%
818	Gerstmann Syndrome	0.3%
819	Hearing Loss, Bilateral	0.3%
820	Hearing Loss, High-Frequency	0.3%
821	Hearing Loss, Mixed Conductive-Sensorineural	0.3%
822	Prosopagnosia	0.3%
823	Apraxia, Ideomotor	0.3%
824	Charles Bonnet Syndrome	0.3%
825	Hearing Loss, Unilateral	0.3%
826	Complete Hearing Loss	0.3%
827	Alien Hand Syndrome	0.3%
828	Deaf Mutism	0.3%
829	Cluster Headache	0.3%
830	Migraine with Aura	0.3%
831	Familial Hemiplegic Migraine	0.3%
832	Chronic Paroxysmal Hemicrania	0.3%
833	SUNCT Syndrome	0.3%
834	Paroxysmal Hemicrania	0.3%
835	Waterhouse-Friderichsen Syndrome	0.3%
836	Dermatomyositis	0.3%
837	Muscular Dystrophy, Duchenne	0.3%
838	Retrograde amnesia	0.3%
839	Amnesia, Anterograde	0.3%
840	Carotid Artery Thrombosis	0.3%
841	Lateral Medullary Syndrome	0.3%
842	Hyperprolactinemia	0.3%
843	Fragile X Syndrome	0.3%
844	Subclavian Steal Syndrome	0.3%
845	Pick Disease of the Brain	0.3%
846	Cataplexy	0.3%
847	Aphasia	0.3%
848	Articulation Disorders	0.3%
849	Echolalia	0.3%
850	Stuttering	0.3%
851	Dysphasia	0.3%
852	Galactosemias	0.2%
853	Urea Cycle Disorders, Inborn	0.2%
854	Tyrosinemias	0.2%
855	Mutism	0.2%
856	Selective Mutism	0.2%
857	Acromegaly	0.2%
858	Cerebral Amyloid Angiopathy	0.2%
859	Sinus Thrombosis, Intracranial	0.2%
860	Fabry Disease	0.2%
861	Homocystinuria	0.2%
862	Leigh Disease	0.2%
863	Mucopolysaccharidosis II	0.2%
864	Dysarthria	0.2%
865	Prolactinoma	0.2%
866	Growth Hormone-Secreting Pituitary Adenoma	0.2%
867	Zellweger Syndrome	0.2%
868	Alexia, Pure	0.2%
869	Cavernous Sinus Thrombosis	0.2%
870	Sagittal Sinus Thrombosis	0.2%
871	Nelson Syndrome	0.2%
872	Carbamoyl-Phosphate Synthase I Deficiency Disease	0.1%
873	Glycogen storage disease type II	0.1%
874	Gaucher Disease	0.1%
875	Niemann-Pick Disease, Type C	0.1%
876	Tay-Sachs Disease	0.1%

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