MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Pulmonary Valve Stenosis

(UMLS:C0034089)

Definition:: The pathologic narrowing of the orifice of the PULMONARY VALVE. This lesion restricts blood outflow from the RIGHT VENTRICLE to the PULMONARY ARTERY. When the trileaflet valve is fused into an imperforate membrane, the blockage is complete.
UMLS ID:: C0034089
MeSH ID:: D011666

Classification:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.280.484.716|C14.280.955.750

Synonym(s)

Pulmonary Valve Stenosis

PS - Pulmonary valve stenosis

PULMONARY VALVE, STENOSIS, PURE

PULMONIC VALVE STENOSIS

PULMONIC VALVULAR STENOSIS

PVS - Pulmonary valve stenosis

Pulmonary valve stenosis

Pulmonary valve--Stenosis

Pulmonic valve stenosis

10.

Pulmonic valve stenosis, NOS

11.

pulmonary stenosis

12.

pulmonary stenosis valve

13.

pulmonary valve stenosis

14.

pulmonary valve; stenosis

15.

pulmonary valve; stricture

16.

pulmonary; stenosis, valve

17.

pulmonary; stricture pulmonary valve

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Paroxetine	FAERS: 130 Canada Vigilance: 1		Canada Vigilance US FAERS
2	Fluoxetine	FAERS: 70		US FAERS
3	Sertraline	FAERS: 65		US FAERS
4	Ondansetron	FAERS: 30		US FAERS
5	Venlafaxine Hydrochloride	FAERS: 26		US FAERS
6	Lamotrigine	FAERS: 17		US FAERS
7	Paroxetine	FAERS: 14		US FAERS
8	Citalopram	FAERS: 7		US FAERS
9	Valproic Acid	FAERS: 6		OFFSIDES US FAERS
10	Valproic Acid	FAERS: 5		US FAERS
11	Topiramate	FAERS: 4		US FAERS
12	Lisinopril	FAERS: 3		US FAERS
13	Mycophenolic Acid	FAERS: 3		US FAERS
14	Naproxen	FAERS: 3		US FAERS
15	Atenolol	FAERS: 2		US FAERS
16	Citalopram	FAERS: 2		US FAERS
17	Fluoxetine	FAERS: 2		US FAERS
18	Pamidronate	FAERS: 2		US FAERS
19	Valproic Acid	FAERS: 2		US FAERS
20	candesartan cilexetil	FAERS: 2		US FAERS
21	pimecrolimus	FAERS: 2		OFFSIDES US FAERS
22	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 1		US FAERS
23	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1		US FAERS
24	Atorvastatin	FAERS: 1		US FAERS
25	Cetirizine	FAERS: 1		US FAERS
26	Clomiphene	FAERS: 1		US FAERS
27	Clopidogrel	FAERS: 1		US FAERS
28	Dimethyl Fumarate	FAERS: 1		US FAERS
29	Erythromycin	FAERS: 1		US FAERS
30	Fluconazole	FAERS: 1		OFFSIDES US FAERS
31	Fluvoxamine	FAERS: 1		US FAERS
32	Imatinib Mesylate	FAERS: 1		US FAERS
33	Imipramine	FAERS: 1		US FAERS
34	Lisdexamfetamine Dimesylate	FAERS: 1		US FAERS
35	Methylergonovine	FAERS: 1		US FAERS
36	NuvaRing	FAERS: 1		US FAERS
37	Octreotide	FAERS: 1		US FAERS
38	Propranolol	FAERS: 1		OFFSIDES US FAERS
39	Quetiapine Fumarate	FAERS: 1		US FAERS
40	Tacrolimus	FAERS: 1		US FAERS
41	Telbivudine	FAERS: 1		US FAERS
42	Temozolomide	FAERS: 1		US FAERS
43	Teriparatide	FAERS: 1		US FAERS
44	adefovir dipivoxil	FAERS: 1		US FAERS
45	apixaban	FAERS: 1		US FAERS
46	efavirenz	FAERS: 1		US FAERS
47	fluticasone furoate	FAERS: 1		US FAERS
48	indacaterol	FAERS: 1		US FAERS
49	pirfenidone	FAERS: 1		US FAERS
50	rofecoxib	FAERS: 1		US FAERS
51	Ampicillin			OFFSIDES
52	Azithromycin			OFFSIDES
53	Bortezomib			OFFSIDES
54	Bupropion			OFFSIDES
55	Butorphanol			OFFSIDES
56	Captopril			OFFSIDES
57	Cefadroxil			OFFSIDES
58	Cefdinir			OFFSIDES
59	Cephalexin			OFFSIDES
60	Chlorothiazide			OFFSIDES
61	Chlorpromazine			OFFSIDES
62	Clindamycin			OFFSIDES
63	Clorazepate Dipotassium			OFFSIDES
64	Deamino Arginine Vasopressin			OFFSIDES
65	Dichloroacetic Acid		27518881	CTD
66	Digoxin			OFFSIDES
67	Docusate sodium			OFFSIDES
68	Hydroxyzine			OFFSIDES
69	Ibuprofen			OFFSIDES
70	Indinavir			OFFSIDES
71	Ketoconazole			OFFSIDES
72	Leflunomide			OFFSIDES
73	Mebendazole			OFFSIDES
74	Medroxyprogesterone			OFFSIDES
75	Metolazone			OFFSIDES
76	Metronidazole			OFFSIDES
77	Miconazole			OFFSIDES
78	Nafcillin			OFFSIDES
79	Nelfinavir			OFFSIDES
80	Nevirapine			OFFSIDES
81	Nitrofurantoin			OFFSIDES
82	Nortriptyline			OFFSIDES
83	Nystatin			OFFSIDES
84	Ondansetron	Canada Vigilance: 1		Canada Vigilance
85	Prednisone acetate			OFFSIDES
86	Pyridoxine			OFFSIDES
87	Sulfate			OFFSIDES
88	Sumatriptan			OFFSIDES
89	Tenofovir			OFFSIDES
90	Terbutaline			OFFSIDES
91	Triazolam			OFFSIDES
92	Trichloroacetic Acid		27518881	CTD
93	Trimethoprim, Sulfamethoxazole Drug Combination			OFFSIDES
94	Venlafaxine Hydrochloride			OFFSIDES
95	Vitamin B 12			OFFSIDES
96	Zidovudine			OFFSIDES
97	alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination			OFFSIDES
98	bromoform		27518881	CTD
99	butalbital			OFFSIDES
100	lamivudine, zidovudine drug combination			OFFSIDES
101	metaxalone			OFFSIDES
102	terconazole			OFFSIDES
103	zaleplon			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Aortic Valve Stenosis	66.7%
2	Supravalvular aortic stenosis	49.2%
3	Aortic Valve Insufficiency	44.4%
4	Mitral Valve Insufficiency	44.4%
5	Mitral Valve Stenosis	44.4%
6	Pulmonary Valve Insufficiency	44.4%
7	Tricuspid Valve Insufficiency	44.4%
8	Tricuspid Valve Stenosis	44.4%
9	Myocardial Ischemia	41.4%
10	Cardiac Tamponade	40.9%
11	Endocarditis	40.9%
12	Cardiac Arrest	40.9%
13	Heart failure	40.9%
14	Pericardial effusion	40.9%
15	Pericarditis	40.9%
16	Pneumopericardium	40.9%
17	Cor pulmonale	40.9%
18	Ventricular Dysfunction	40.9%
19	Cardiomyopathies	40.9%
20	Pleuropericarditis	40.9%
21	Hypertrophic Cardiomyopathy	40.3%
22	Hypertrophic obstructive cardiomyopathy	40.3%
23	Cardiomyopathy, Dilated	40%
24	Tricuspid Atresia	39.8%
25	Aortic Valve Prolapse	33%
26	Tricuspid Valve Prolapse	33%
27	Heart Block	32%
28	Tachycardia	32%
29	Tachyarrhythmia	32%
30	Cardiac Output, High	31%
31	Myocardial Stunning	31%
32	Low Cardiac Output Syndrome	31%
33	Arrhythmogenic Right Ventricular Dysplasia	30.9%
34	Cardiomegaly	30.5%
35	Postpericardiotomy Syndrome	30.5%
36	Cardiac Hypertrophy	30.5%
37	Myocardial Reperfusion Injury	30.3%
38	Rheumatic Heart Disease	30.1%
39	Lown-Ganong-Levine Syndrome	29.5%
40	Restrictive cardiomyopathy	26.7%
41	Coronary heart disease	26.7%
42	Endocardial Fibroelastosis	26.7%
43	Heart Rupture, Post-Infarction	26.7%
44	Myocardial Infarction	26.7%
45	Myocarditis	26.7%
46	Pericarditis, Constrictive	26.7%
47	Ventricular Dysfunction, Left	26.7%
48	Right Ventricular Dysfunction	26.7%
49	Endomyocardial Fibrosis	26.7%
50	Carditis	26.7%
51	Acute Coronary Syndrome	26.7%
52	Heart Failure, Systolic	26.7%
53	Heart Failure, Diastolic	26.7%
54	Long QT Syndrome	26.5%
55	Sick Sinus Syndrome	25.1%
56	Vascular Diseases	23.8%
57	Adams-Stokes Syndrome	23.5%
58	Atrioventricular Block	23.5%
59	Bundle-Branch Block	23.5%
60	Atrial Premature Complexes	23.5%
61	Sinoatrial Block	23.5%
62	Tachycardia, Paroxysmal	23.5%
63	Supraventricular tachycardia	23.5%
64	Tachycardia, Ventricular	23.5%
65	Wolff-Parkinson-White Syndrome	23.5%
66	Tachycardia, Reciprocating	23.5%
67	Kounis Syndrome	21.6%
68	Aortic coarctation	21.2%
69	Cor Triatriatum	21.2%
70	Coronary Vessel Anomalies	21.2%
71	Patent ductus arteriosus	21.2%
72	Ebstein Anomaly	21.2%
73	Heart Septal Defects	21.2%
74	Tetralogy of Fallot	21.2%
75	Transposition of Great Vessels	21.2%
76	Hypoplastic Left Heart Syndrome	21.2%
77	Angina Pectoris	21.1%
78	Coronary Aneurysm	21.1%
79	Bacterial Endocarditis	20.5%
80	Ventricular Outflow Obstruction	20.5%
81	Sinus Arrhythmia	20%
82	Atrial Fibrillation	20%
83	Atrial Flutter	20%
84	Edema, Cardiac	20%
85	Pulmonary Valve Stenosis	20%
86	Ventricular Fibrillation	20%
87	Ventricular Flutter	20%
88	Parasystole	20%
89	Paroxysmal atrial fibrillation	20%
90	Bradycardia	20%
91	Diabetic Cardiomyopathies	20%
92	Cardiomyopathy, Alcoholic	19.8%
93	Sudden Cardiac Death	19.8%
94	Left Ventricular Hypertrophy	19.8%
95	Right Ventricular Hypertrophy	19.8%
96	Takotsubo Cardiomyopathy	19.8%
97	Chagas Cardiomyopathy	19.8%
98	Coronary Occlusion	19.7%
99	Microvascular Angina	19.7%
100	Coronary Stenosis	19.7%
101	ST segment elevation myocardial infarction	19.7%
102	Coronary Thrombosis	19.6%
103	Coronary Artery Disease	19.6%
104	Carcinoid Heart Disease	19.6%
105	Romano-Ward Syndrome	19.5%
106	Tachycardia, Atrioventricular Nodal Reentry	19.4%
107	Tachycardia, Ectopic Atrial	19.4%
108	Tachycardia, Ectopic Junctional	19.4%
109	Sinus Tachycardia	19.4%
110	Torsades de Pointes	19.4%
111	Accelerated Idioventricular Rhythm	19.4%
112	Pregnancy Complications, Cardiovascular	17.9%
113	Cardiovascular Abnormalities	17.9%
114	Dextrocardia	17.7%
115	Coronary Restenosis	16.3%
116	Dyspnea, Paroxysmal	15.9%
117	Shock, Cardiogenic	15.8%
118	Aortopulmonary Septal Defect	15.6%
119	Double Outlet Right Ventricle	15.6%
120	Endocardial Cushion Defects	15.6%
121	Myocardial bridging	15.6%
122	Aorticopulmonary Septal Defect	15.6%
123	Angina, Unstable	15.6%
124	Sinus Arrest, Cardiac	14.8%
125	Williams Syndrome	13.7%
126	Aneurysm	13.6%
127	Angiomatosis	13.6%
128	Aortic Diseases	13.6%
129	Arterial Occlusive Diseases	13.6%
130	Hyperemia	13.6%
131	Hypotension	13.6%
132	Superior Vena Cava Syndrome	13.6%
133	Telangiectasis	13.6%
134	Vasculitis	13.6%
135	Venous Insufficiency	13.6%
136	Peripheral Vascular Diseases	13.6%
137	Embolism and Thrombosis	13.6%
138	Angiodysplasia	13.6%
139	Capillary Leak Syndrome	13.6%
140	Prehypertension	13.6%
141	Aortic Aneurysm	13.3%
142	Aortitis	13.3%
143	Leriche Syndrome	13.3%
144	Noonan Syndrome	13.3%
145	Periphlebitis	13.3%
146	Phlebitis	13.3%
147	Thromboangiitis Obliterans	13.3%
148	Truncus Arteriosus, Persistent	12.9%
149	Angina Pectoris, Variant	12.9%
150	Subacute Bacterial Endocarditis	12.2%
151	Embolism, Amniotic Fluid	12.1%
152	Marfan Syndrome	12%
153	Postphlebitic Syndrome	11.6%
154	Retinal Vein Occlusion	11.5%
155	Arteriovenous fistula	11.5%
156	Thrombophlebitis	11.1%
157	Vascular System Injuries	10.7%
158	Malignant Atrophic Papulosis	10.7%
159	Shwartzman Phenomenon	10.6%
160	May-Thurner Syndrome	10.6%
161	Compartment syndromes	10.3%
162	Hepatic Veno-Occlusive Disease	10.3%
163	Peliosis Hepatis	10.3%
164	Varicocele	10.3%
165	Blue Toe Syndrome	10.3%
166	Cerebrovascular Disorders	10.2%
167	Diabetic Angiopathies	10.2%
168	Reperfusion Injury	10.2%
169	Splenic Infarction	10.2%
170	Cerebrovascular Insufficiency	10.2%
171	Vascular Neoplasms	10.2%
172	Spinal Cord Vascular Diseases	10.2%
173	Vasoplegia	10.2%
174	Hemorrhoids	10.1%
175	Thoracic Outlet Syndrome	10.1%
176	Aortic Rupture	9.9%
177	Aortic Aneurysm, Abdominal	9.8%
178	Aortic Aneurysm, Thoracic	9.8%
179	Intracranial Embolism and Thrombosis	9.2%
180	Carotid Artery Thrombosis	9.2%
181	Carotid Stenosis	9.2%
182	Intracranial Aneurysm	9.2%
183	Aneurysm, Dissecting	8.9%
184	Arteriosclerosis	8.9%
185	Arteritis	8.9%
186	Embolism	8.9%
187	Erythromelalgia	8.9%
188	Fibromuscular Dysplasia	8.9%
189	Malignant Hypertension	8.9%
190	Raynaud Disease	8.9%
191	Thromboembolism	8.9%
192	Thrombosis	8.9%
193	Essential Hypertension	8.9%
194	Aneurysm, Ruptured	8.9%
195	Iliac Aneurysm	8.9%
196	Pulmonary artery stenosis	8.9%
197	White Coat Hypertension	8.9%
198	Systemic Vasculitis	8.9%
199	Embolus	8.9%
200	Moyamoya Disease	8.8%
201	Scimitar Syndrome	8.5%
202	Hand-Arm Vibration Syndrome	8.5%
203	Optic Neuropathy, Ischemic	8.2%
204	Anterior Ischemic Optic Neuropathy	8.2%
205	Mesenteric vascular insufficiency	8.2%
206	Angioedema	8%
207	Colitis, Ischemic	8%
208	Polyarteritis Nodosa	7.9%
209	Takayasu Arteritis	7.9%
210	Intracranial Arteriosclerosis	7.8%
211	Cerebral Atherosclerosis	7.8%
212	Cerebral Arteriosclerosis	7.8%
213	Vasculitis, Central Nervous System	7.7%
214	Cerebral Thrombosis	7.1%
215	Intracranial Embolism	7.1%
216	Intracranial Thrombosis	7.1%
217	Turner Syndrome	6.9%
218	Retinal Artery Occlusion	6.8%
219	Retinal Vasculitis	6.8%
220	Hypertensive Retinopathy	6.8%
221	Anterior Compartment Syndrome	6.7%
222	Vasculitis, Leukocytoclastic, Cutaneous	6.7%
223	Gastric Antral Vascular Ectasia	6.7%
224	Abdominal Compartment Syndrome	6.7%
225	Carotid Artery Diseases	6.6%
226	Brain Ischemia	6.6%
227	Ectopia Cordis	6.6%
228	Hypotension, Orthostatic	6.6%
229	Cerebrovascular accident	6.6%
230	Varicose Ulcer	6.6%
231	Vasospasm, Intracranial	6.6%
232	Spinal Cord Ischemia	6.6%
233	Intracranial Arterial Diseases	6.6%
234	Primary Graft Dysfunction	6.6%
235	Single umbilical artery	6.6%
236	Post-Exercise Hypotension	6.6%
237	Arteriosclerosis Obliterans	6.6%
238	Atherosclerosis	6.6%
239	Air Embolism	6.6%
240	Endarteritis	6.6%
241	Venous Thrombosis	6.6%
242	Deep Vein Thrombosis	6.6%
243	Venous Thromboembolism	6.6%
244	Giant Cell Arteritis	6.5%
245	Temporal Arteritis	6.5%
246	Brain Infarction	6.5%
247	Kearns-Sayre syndrome	6.5%
248	Sinus Thrombosis, Intracranial	6.1%
249	Lemierre Syndrome	6%
250	Kartagener Syndrome	5.7%
251	Subarachnoid Hemorrhage, Traumatic	5.7%
252	Carotid Artery, Internal, Dissection	5.7%
253	CREST Syndrome	5.7%
254	Cavernous Sinus Thrombosis	5.6%
255	Sagittal Sinus Thrombosis	5.6%
256	Vertebral Artery Dissection	5.6%
257	Infarction, Middle Cerebral Artery	5.6%
258	Infarction, Anterior Cerebral Artery	5.6%
259	Infarction, Posterior Cerebral Artery	5.6%
260	Mesenteric Vascular Occlusion	5.4%
261	Mucocutaneous Lymph Node Syndrome	5.4%
262	Diabetic Retinopathy	5.4%
263	Sturge-Weber Syndrome	5.4%
264	Cerebral Infarction	5.4%
265	Brain Stem Infarctions	5.4%
266	Livedo Reticularis	5.3%
267	Renal hypertension	5.3%
268	Renal Artery Obstruction	5.3%
269	Renal Artery Stenosis	5.3%
270	Hemangioma, Cavernous	5.3%
271	Basal Ganglia Cerebrovascular Disease	5.3%
272	Vascular Headaches	5.2%
273	Scurvy	5.2%
274	Intermittent Claudication	5%
275	Pulmonary Embolism	5%
276	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	5%
277	No-Reflow Phenomenon	5%
278	Cerebral Arterial Diseases	4.9%
279	Vertebrobasilar Insufficiency	4.9%
280	Carotid Artery Injuries	4.9%
281	Anterior Spinal Artery Syndrome	4.9%
282	Basilar Artery Stenosis	4.9%
283	Vertebral Artery Stenosis	4.9%
284	Intracranial Hemorrhage, Hypertensive	4.9%
285	Transient Cerebral Ischemia	4.9%
286	Lateral Medullary Syndrome	4.8%
287	Dural Arteriovenous Fistula	4.5%
288	Ischemic contracture	4.4%
289	Basal Ganglia Hemorrhage	4.4%
290	Angioedemas, Hereditary	4.4%
291	Cryoglobulinemia	4.4%
292	Leukomalacia, Periventricular	4.4%
293	Diabetic Foot	4.4%
294	Hepatic Vein Thrombosis	4.2%
295	Budd-Chiari Syndrome	4.2%
296	Pulmonary Infarction	4.1%
297	Subclavian Steal Syndrome	4.1%
298	Hypertension, Renovascular	3.9%
299	Subarachnoid Hemorrhage	3.9%
300	Hypoxia-Ischemia, Brain	3.9%
301	Cerebral Hemorrhage	3.9%
302	Hereditary Angioedema Type III	3.9%
303	Hereditary Angioedema Types I and II	3.9%
304	Putaminal Hemorrhage	3.8%
305	Shy-Drager Syndrome	3.7%
306	Purpura, Hyperglobulinemic	3.7%
307	Dementia, Vascular	3.6%
308	Behcet Syndrome	3.3%
309	Waldenstrom Macroglobulinemia	3.3%
310	Multiple Myeloma	3.3%
311	Granulomatosis with polyangiitis	3.3%
312	Pituitary Apoplexy	3.3%
313	Cerebral Amyloid Angiopathy	3.2%
314	Lupus Vasculitis, Central Nervous System	3%
315	Ataxia Telangiectasia	3%
316	Pseudoxanthoma Elasticum	3%
317	Rheumatoid Vasculitis	2.8%
318	Hematoma, Subdural	2%
319	Hematoma, Epidural, Cranial	2%
320	Hematoma, Subdural, Intracranial	1.8%
321	Hematoma, Subdural, Chronic	1.8%
322	Hematoma, Subdural, Acute	1.8%
323	Brain Hemorrhage, Traumatic	1.8%
324	MELAS Syndrome	1.8%
325	Fabry Disease	1.4%

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