MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Goldenhar Syndrome

(UMLS:C0265240)

Definition:: Mandibulofacial dysostosis with congenital eyelid dermoids.
UMLS ID:: C0265240
MeSH ID:: D006053

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.099.370.231.576.410|C05.660.207.231.576.410

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.621.207.231.576.410

Synonym(s)

Goldenhar Syndrome

Craniofacial microsomia

Facio-auriculo-vertebral anomalad

Facio-auriculo-vertebral spectrum

First and second arch syndrome

First and second branchial arch syndrome

First arch syndrome

First arch syndrome, NOS

Franceschetti-Goldenhar syndrome

10.

Goldenhar

11.

Goldenhar sequence

12.

Goldenhar syndrome

13.

Goldenhar syndrome (GS)

14.

Goldenhar's syndrome

15.

Goldenhar-Gorlin syndrome

16.

Oculoauricular vertebral dysplasia

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Primidone		4035586	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Platybasia	30.6%
2	Klippel-Feil Syndrome	29.2%
3	Synostosis	29.2%
4	Pectus excavatum	28.3%
5	Craniosynostosis	27.9%
6	Brachycephaly	27.9%
7	Pectus carinatum	25.1%
8	Plagiocephaly	24.7%
9	Arthrogryposis	24.4%
10	Rubinstein-Taybi Syndrome	24.2%
11	Limb Deformities, Congenital	21.9%
12	Maxillofacial Abnormalities	21.1%
13	Syndactyly	19.8%
14	Holoprosencephaly	18.9%
15	Microcephaly	18.6%
16	Macrocephaly	18.6%
17	Gastroschisis	18.2%
18	Acrocephalosyndactylia	17.7%
19	Osteoarthropathy, Secondary Hypertrophic	17.2%
20	Noonan Syndrome	15.4%
21	Gigantism	14.9%
22	Multiple Epiphyseal Dysplasia	14.7%
23	Osteochondrodysplasias	14.7%
24	Osteochondritis	14.4%
25	Fasciitis	14.1%
26	Foot Deformities	14.1%
27	Arthropathy	14.1%
28	Hyperostosis	14%
29	Osteitis	14%
30	Osteitis Deformans	14%
31	Osteochondrosis	14%
32	Spinal Diseases	14%
33	Jaw Abnormalities	12.9%
34	Antley-Bixler Syndrome Phenotype	12.8%
35	Dwarfism	12.7%
36	Poland Syndrome	12%
37	Amelia	11.9%
38	Arachnodactyly	11.9%
39	Ectromelia	11.9%
40	Hemimelia	11.9%
41	Phocomelia	11.9%
42	Sirenomelia	11.9%
43	Polydactyly	11.9%
44	Brachydactyly	11.9%
45	Lower Extremity Deformities, Congenital	11.9%
46	Upper Extremity Deformities, Congenital	11.9%
47	Bone Diseases, Endocrine	11.7%
48	Jaw Diseases	11.7%
49	Contracture	11.6%
50	Fasciitis, Plantar	11.6%
51	Porencephaly	11.5%
52	Bone Diseases, Infectious	11.4%
53	Bone neoplasms	11.4%
54	Osteopenia	11.4%
55	Cartilage Diseases	11.4%
56	Foot Diseases	11.4%
57	Myopathy	11.4%
58	Rheumatism	11.4%
59	Chondromalacia	11.4%
60	Bone Resorption	11.3%
61	Aseptic Necrosis of Bone	11.3%
62	Marfan Syndrome	10.9%
63	Abnormalities, Drug-Induced	10.4%
64	Situs Inversus	10.4%
65	Laryngomalacia	10.3%
66	Spinal Neoplasms	10%
67	Spondylitis	10%
68	Fibromyalgia	9.7%
69	Polymyalgia Rheumatica	9.7%
70	Metatarsalgia	9.6%
71	Nail-Patella Syndrome	9.4%
72	Congenital Hypothyroidism	8.9%
73	Eye Abnormalities	8.7%
74	Cardiovascular Abnormalities	8.7%
75	Beckwith-Wiedemann Syndrome	8.5%
76	Wolf-Hirschhorn Syndrome	8.5%
77	Skin Abnormalities	8.4%
78	Lymphatic Abnormalities	8.4%
79	Congenital Microtia	8.4%
80	Congenital diaphragmatic hernia	8.3%
81	Chondrodysplasia Punctata	8.1%
82	Enchondromatosis	8.1%
83	Osteosclerosis	8.1%
84	Kashin-Beck Disease	8.1%
85	Basal Cell Nevus Syndrome	8.1%
86	Gout	8%
87	Micrognathism	7.9%
88	Pierre Robin Syndrome	7.9%
89	Prognathism	7.9%
90	Osteogenesis Imperfecta	7.9%
91	Cockayne Syndrome	7.8%
92	Aicardi's syndrome	7.7%
93	Talipes	7.7%
94	Ainhum	7.4%
95	Spinal Stenosis	7.4%
96	Spondylosis	7.4%
97	Intervertebral Disc Degeneration	7.4%
98	Smith-Magenis syndrome	7.4%
99	Rheumatic Fever	7.3%
100	Cri-du-Chat Syndrome	7.3%
101	Down Syndrome	7.3%
102	Trisomy 21	7.3%
103	Urogenital Abnormalities	7.3%
104	Retrognathia	7.2%
105	Bone Diseases	7.1%
106	Arthritis	7.1%
107	Bursitis	7.1%
108	Joint Instability	7.1%
109	Myofascial Pain Syndromes	7.1%
110	Rhabdomyolysis	7.1%
111	Synovitis	7.1%
112	Joint laxity	7.1%
113	Polyarthritis	7.1%
114	Frozen shoulder	7.1%
115	Patellofemoral Pain Syndrome	7.1%
116	Eosinophilic Granuloma	7%
117	Cleft Palate	7%
118	Genetic Diseases, Inborn	6.9%
119	Temporomandibular Joint Disorders	6.8%
120	Ischemic contracture	6.6%
121	Ectodermal Dysplasia	6.4%
122	Aplasia Cutis Congenita	6.4%
123	Rheumatoid Arthritis	6.4%
124	Juvenile arthritis	6.4%
125	Prader-Willi Syndrome	6.4%
126	Bronchomalacia	6.2%
127	Tracheomalacia	6.2%
128	Osteoarthritis, Spine	6.2%
129	Hip Contracture	6.1%
130	Periarthritis	6.1%
131	CHARGE Syndrome	6%
132	Osteomyelitis	6%
133	Osteoporosis	6%
134	Periostitis	6%
135	Bone Demineralization, Pathologic	6%
136	Post-Traumatic Osteoporosis	6%
137	Alveolar Bone Loss	5.9%
138	Femur Head Necrosis	5.9%
139	Osteolysis	5.9%
140	Compartment syndromes	5.8%
141	Maxillary Diseases	5.8%
142	Tendinitis	5.8%
143	Tendinopathy	5.8%
144	Hemarthrosis	5.7%
145	Myositis	5.7%
146	Tietze's Syndrome	5.7%
147	Isaacs syndrome	5.7%
148	Myotonic Disorders	5.7%
149	Anencephaly	5.6%
150	Fetal Diseases	5.6%
151	Discitis	5.6%
152	Prune Belly Syndrome	5.4%
153	Twins, Conjoined	5.4%
154	Waardenburg Syndrome	5.4%
155	Abnormalities, Radiation-Induced	5.2%
156	Xeroderma	5.2%
157	Mobius Syndrome	5.2%
158	Temporomandibular Joint Dysfunction Syndrome	5.1%
159	Acromegaly	5%
160	Joint Tuberculosis	5%
161	Tuberculosis, Osteoarticular	5%
162	Bone Tuberculosis	5%
163	Melorheostosis	4.9%
164	Osteopetrosis	4.9%
165	Congenital clubfoot	4.9%
166	Vertical Talus	4.9%
167	Dural Arteriovenous Fistula	4.9%
168	Muscular Dystrophy	4.9%
169	Dextrocardia	4.9%
170	Medial Tibial Stress Syndrome	4.8%
171	Osteoarthritis, Knee	4.8%
172	Mitochondrial Myopathies	4.8%
173	Tuberculosis, Spinal	4.8%
174	Muscle Cramp	4.8%
175	Eosinophilia-Myalgia Syndrome	4.8%
176	Muscle Rigidity	4.7%
177	Muscle Spasticity	4.7%
178	Cogwheel Rigidity	4.7%
179	Nuchal Rigidity	4.7%
180	Familial Periodic Paralysis	4.7%
181	Ankylosing spondylitis	4.6%
182	Kartagener Syndrome	4.5%
183	Anophthalmos	4.4%
184	Anus, Imperforate	4.4%
185	Hydranencephaly	4.4%
186	Microphthalmos	4.4%
187	Neural Tube Defects	4.4%
188	Tethered Cord Syndrome	4.4%
189	Iniencephaly	4.4%
190	Craniorachischisis	4.4%
191	Exencephaly	4.4%
192	Septo-Optic Dysplasia	4.4%
193	Cortical Dysplasia	4.4%
194	Malformations of Cortical Development	4.4%
195	Anorectal Malformations	4.4%
196	Arthritis, Gouty	4.4%
197	Bloom Syndrome	4.4%
198	Chronic Fatigue Syndrome	4.3%
199	Rickets	4.3%
200	Pseudohypoparathyroidism	4.3%
201	Lordosis	4.2%
202	Spondylolysis	4.2%
203	kyphosis	4.2%
204	Polycystic Kidney Diseases	4.1%
205	Williams Syndrome	4.1%
206	Giant Cell Epulis	4.1%
207	Muscle Weakness	4.1%
208	Cystic Fibrosis	4.1%
209	Musculoskeletal Pain	4.1%
210	Arthralgia	4.1%
211	Polyarthralgia	4.1%
212	Rheumatoid Nodule	4%
213	Arthritis, Psoriatic	4%
214	Myotonic Dystrophy	3.9%
215	Scimitar Syndrome	3.9%
216	Spondylarthropathies	3.8%
217	Bunion	3.8%
218	Fibrodysplasia Ossificans Progressiva	3.8%
219	Myoglobinuria	3.8%
220	Myositis Ossificans	3.8%
221	Tenosynovitis	3.8%
222	Sacroiliitis	3.8%
223	Retinal Dysplasia	3.8%
224	Aniridia	3.7%
225	Blepharophimosis	3.7%
226	Laryngostenosis	3.7%
227	Mouth Abnormalities	3.7%
228	Esophageal Atresia	3.7%
229	Intestinal Atresia	3.7%
230	Horseshoe Kidney	3.7%
231	Epidermolysis Bullosa	3.7%
232	Bone Diseases, Developmental	3.7%
233	Acrodermatitis	3.6%
234	Lymphangiectasis, Intestinal	3.6%
235	Gianotti-Crosti Syndrome	3.6%
236	Meconium Aspiration Syndrome	3.6%
237	Myalgia	3.5%
238	Felty Syndrome	3.5%
239	Abdominal Cramps	3.5%
240	Amniotic Band Syndrome	3.5%
241	Asphyxia Neonatorum	3.5%
242	Infant, Premature, Diseases	3.5%
243	Infantile Colic	3.5%
244	Osteoporosis, Postmenopausal	3.3%
245	Muscular Dystrophy, Duchenne	3.3%
246	Smith-Lemli-Opitz Syndrome	3.3%
247	Alstrom Syndrome	3.3%
248	Myotonia Congenita	3.2%
249	Choanal Atresia	3.2%
250	Tracheobronchomegaly	3.2%
251	Laryngocele	3.2%
252	Choledochal Cyst	3.2%
253	Hermaphroditism	3.2%
254	Disorders of Sex Development	3.2%
255	Ichthyosis, X-Linked	3.2%
256	Cryptorchidism	3.2%
257	Hypospadias	3.2%
258	Central Nervous System Cysts	3.2%
259	Dandy-Walker Syndrome	3.1%
260	POEMS Syndrome	3.1%
261	Arthritis, Infectious	3.1%
262	Arthritis, Reactive	3.1%
263	Anterior Compartment Syndrome	3.1%
264	Enthesopathy	3.1%
265	Arthritis, Experimental	3.1%
266	Abdominal Compartment Syndrome	3.1%
267	Polymyositis	3%
268	Rheumatoid Vasculitis	3%
269	Fragile X Syndrome	3%
270	Pseudoxanthoma Elasticum	3%
271	Primary Ciliary Dyskinesia	2.9%
272	Neoplastic Syndromes, Hereditary	2.9%
273	Palatal Neoplasms	2.9%
274	Mastoiditis	2.8%
275	Petrositis	2.8%
276	Anemia, Neonatal	2.8%
277	Pelger-Huet Anomaly	2.8%
278	Persistent Fetal Circulation Syndrome	2.8%
279	Werner Syndrome	2.8%
280	Craniofacial Abnormalities	2.8%
281	Myasthenic Syndromes, Congenital	2.8%
282	Bladder Exstrophy	2.8%
283	Epispadias	2.8%
284	Umbilical hernia	2.8%
285	Multicystic Dysplastic Kidney	2.7%
286	Xeroderma Pigmentosum	2.7%
287	Sicca Syndrome	2.7%
288	Sjogren's Syndrome	2.7%
289	Welander Distal Myopathy	2.7%
290	Hip Dislocation	2.6%
291	Shoulder Dislocation	2.6%
292	Hip Dysplasia	2.6%
293	Orbital Myositis	2.6%
294	Dupuytren Contracture	2.6%
295	Spondylolisthesis	2.6%
296	Pyomyositis	2.6%
297	Hypokalemic periodic paralysis	2.5%
298	Sjogren-Larsson Syndrome	2.4%
299	Ectopia Cordis	2.4%
300	Meningomyelocele	2.4%
301	Spina Bifida	2.4%
302	Single umbilical artery	2.4%
303	Osteomalacia	2.4%
304	Neonatal Abstinence Syndrome	2.4%
305	Kallmann Syndrome	2.3%
306	Fetal Growth Retardation	2.3%
307	Fetal Hypoxia	2.3%
308	Congenital nystagmus	2.3%
309	Fetal Alcohol Spectrum Disorders	2.3%
310	Zellweger Syndrome	2.3%
311	Toxoplasmosis, Congenital	2.3%
312	Syphilis, Congenital	2.3%
313	Polycystic Kidney, Autosomal Dominant	2.3%
314	Turner Syndrome	2.3%
315	Shoulder Pain	2.2%
316	Anemia, Sickle Cell	2.1%
317	Thalassemia	2.1%
318	Aortic coarctation	2%
319	Cor Triatriatum	2%
320	Coronary Vessel Anomalies	2%
321	Dental Enamel Hypoplasia	2%
322	Patent ductus arteriosus	2%
323	Ebstein Anomaly	2%
324	Heart Septal Defects	2%
325	Hypodontia	2%
326	Macrostomia	2%
327	Meningocele	2%
328	Microstomia	2%
329	Tetralogy of Fallot	2%
330	Transposition of Great Vessels	2%
331	Hypoplastic Left Heart Syndrome	2%
332	May-Thurner Syndrome	2%
333	Encephalocele	2%
334	Autoimmune Lymphoproliferative Syndrome	2%
335	Craniofacial Dysostosis	2%
336	Charcot-Marie-Tooth Disease	2%
337	Dysostoses	2%
338	Congenital Hyperinsulinism	2%
339	Wolff-Parkinson-White Syndrome	2%
340	Classical Lissencephalies and Subcortical Band Heterotopias	2%
341	Chorioamnionitis	2%
342	Angioedemas, Hereditary	2%
343	Mitochondrial Encephalomyopathies	1.9%
344	Albinism	1.9%
345	Tuberous Sclerosis	1.9%
346	Familial Mediterranean Fever	1.8%
347	Nose Neoplasms	1.8%
348	Long QT Syndrome	1.7%
349	Tricuspid Atresia	1.7%
350	Arrhythmogenic Right Ventricular Dysplasia	1.7%
351	Gonadal Dysgenesis	1.7%
352	Adrenogenital Syndrome	1.7%
353	Ovotesticular Disorders of Sex Development	1.7%
354	Refsum Disease	1.7%
355	Renal Osteodystrophy	1.7%
356	Renal rickets	1.7%
357	Hyperkeratosis, Epidermolytic	1.7%
358	Klinefelter Syndrome	1.7%
359	Wiskott-Aldrich Syndrome	1.6%
360	Ophthalmia Neonatorum	1.5%
361	Paralysis, Obstetric	1.5%
362	Retinopathy of Prematurity	1.5%
363	Amino Acid Metabolism, Inborn Errors	1.5%
364	Carbohydrate Metabolism, Inborn Errors	1.5%
365	Metal Metabolism, Inborn Errors	1.5%
366	Progeria	1.5%
367	Lysosomal Storage Diseases	1.5%
368	Cytochrome-c Oxidase Deficiency	1.5%
369	Peroxisomal Disorders	1.5%
370	Bronchopulmonary Dysplasia	1.4%
371	Dermal Sinus	1.4%
372	Spina Bifida Cystica	1.4%
373	Spina Bifida Occulta	1.4%
374	Lissencephaly	1.4%
375	Polymicrogyria	1.4%
376	Pachygyria	1.4%
377	Schizencephaly	1.4%
378	Periventricular Nodular Heterotopia	1.4%
379	Ataxia Telangiectasia	1.4%
380	Rett Syndrome	1.3%
381	Hyperandrogenism	1.3%
382	Dermatomyositis	1.3%
383	Respiratory Distress Syndrome, Newborn	1.2%
384	Menkes Kinky Hair Syndrome	1.2%
385	Cutis Laxa	1.2%
386	Retinitis Pigmentosa	1.2%
387	Pigmentary retinopathy	1.2%
388	Porokeratosis	1.2%
389	Keratoderma, Palmoplantar	1.2%
390	Chronic granulomatous disease	1.2%
391	Neuronal Ceroid-Lipofuscinoses	1.2%
392	Aortopulmonary Septal Defect	1.2%
393	Double Outlet Right Ventricle	1.2%
394	Endocardial Cushion Defects	1.2%
395	Myocardial bridging	1.2%
396	Aorticopulmonary Septal Defect	1.2%
397	Mucopolysaccharidosis II	1.2%
398	Sickle Cell Trait	1.1%
399	Amyloid Neuropathies, Familial	1.1%
400	Hepatolenticular Degeneration	1.1%
401	Duane Retraction Syndrome	1.1%
402	MELAS Syndrome	1.1%
403	Porphyrias, Hepatic	1.1%
404	Peutz-Jeghers Syndrome	1%
405	Thrombasthenia	1%
406	Antithrombin III Deficiency	1%
407	Protein C Deficiency	1%
408	Brain Diseases, Metabolic, Inborn	1%
409	Afibrinogenemia	1%
410	Dystonia Musculorum Deformans	1%
411	Factor VII Deficiency	1%
412	Factor X Deficiency	1%
413	Factor XII Deficiency	1%
414	Hemophilia A	1%
415	Leukomalacia, Periventricular	1%
416	Activated Protein C Resistance	1%
417	Factor II deficiency	1%
418	Factor VIII Deficiency	1%
419	Factor V deficiency	1%
420	Factor XI Deficiency	1%
421	Hypoprothrombinemias	1%
422	Fanconi Anemia	1%
423	Nesidioblastosis	1%
424	Lafora Disease	1%
425	Unverricht-Lundborg Syndrome	1%
426	Mandibulofacial Dysostosis	1%
427	Anemia, Diamond-Blackfan	1%
428	Romano-Ward Syndrome	1%
429	Familial Hypophosphatemic Rickets	1%
430	Hydrops Fetalis	1%
431	Adrenoleukodystrophy	1%
432	Multiple Endocrine Neoplasia	0.9%
433	Dermatitis, Atopic	0.9%
434	Acute Chest Syndrome	0.9%
435	Galactosemias	0.9%
436	Urea Cycle Disorders, Inborn	0.9%
437	Tyrosinemias	0.9%
438	Canavan Disease	0.9%
439	Alexander Disease	0.9%
440	Kernicterus	0.8%
441	Behcet Syndrome	0.8%
442	Optic Atrophy, Hereditary, Leber	0.8%
443	Arteriovenous fistula	0.8%
444	Hyperphosphaturia	0.8%
445	Alkaptonuria	0.8%
446	Glycogen Storage Disease	0.8%
447	Hypophosphatasia	0.8%
448	Propionic acidemia	0.8%
449	Dihydropyrimidine Dehydrogenase Deficiency	0.8%
450	Cystinosis	0.8%
451	Fabry Disease	0.8%
452	Truncus Arteriosus, Persistent	0.8%
453	Goldenhar Syndrome	0.8%
454	Denys-Drash Syndrome	0.7%
455	Huntington Disease	0.7%
456	Radicular Cyst	0.7%
457	Kearns-Sayre syndrome	0.7%
458	Hyaline Membrane Disease	0.7%
459	Hypolipoproteinemias	0.7%
460	Papillon-Lefevre Disease	0.7%
461	Hyperlipidemia, Familial Combined	0.7%
462	Nephroblastoma	0.7%
463	Hyperlipoproteinemia Type III	0.7%
464	Glycogen storage disease type II	0.6%
465	Homocystinuria	0.6%
466	Leigh Disease	0.6%
467	Adenomatous Polyposis Coli	0.6%
468	Mucopolysaccharidosis III	0.6%
469	Lactose Intolerance	0.6%
470	Variegate Porphyria	0.6%
471	Acute intermittent porphyria	0.6%
472	Porphyria Cutanea Tarda	0.6%
473	Hyperhomocysteinemia	0.6%
474	Renal Aminoacidurias	0.6%
475	Fanconi Syndrome	0.6%
476	Pseudohypoaldosteronism	0.6%
477	Liddle Syndrome	0.6%
478	Hyperlipoproteinemia Type IV	0.6%
479	Hyperlipoproteinemia Type V	0.6%
480	Multiple Endocrine Neoplasia Type 1	0.5%
481	Friedreich Ataxia	0.5%
482	Renal tubular acidosis	0.5%
483	Carbamoyl-Phosphate Synthase I Deficiency Disease	0.5%
484	Glycogen Storage Disease Type I	0.5%
485	Glycogen Storage Disease Type V	0.5%
486	Glycosuria, Renal	0.4%
487	Hypoalphalipoproteinemias	0.4%
488	Gaucher Disease	0.4%
489	Cystinuria	0.3%
490	Niemann-Pick Disease, Type C	0.3%
491	Tay-Sachs Disease	0.2%

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