MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Neurofibrosarcoma

(UMLS:C0206729)

Definition:: A malignant tumor that arises from small cutaneous nerves, is locally aggressive, and has a potential for metastasis. Characteristic histopathologic features include proliferating atypical spindle cells with slender wavy and pointed nuclei, hypocellular areas, and areas featuring organized whorls of fibroblastic proliferation. The most common primary sites are the extremities, retroperitoneum, and trunk. These tumors tend to present in childhood, often in association with NEUROFIBROMATOSIS 1. (From DeVita et al., Cancer: Principles & Practice of Oncology, 5th ed, p1662; Mayo Clin Proc 1990 Feb;65(2):164-72)
UMLS ID:: C0206729
MeSH ID:: D018319

Classification 1:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.450.565.590.350.590|C04.557.450.795.350.590|C04.557.580.600.580.795

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.551.775.500.750.750|C10.668.829.725.500.600.600

Synonym(s)

Neurofibrosarcoma

Neurogenic sarcoma

Neurosarcoma

neurofibrosarcoma

neurofibrosarcomas

neurogenic sarcoma

neurogenic sarcomas

neurosarcoma

neurosarcomas

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Imatinib Mesylate	FAERS: 1	US FAERS
2	Imatinib Mesylate	FAERS: 1	US FAERS
3	histrelin	FAERS: 1	US FAERS
4	Dimethyl Fumarate	Canada Vigilance: 1	Canada Vigilance

Similar ADE(s)

	Name	Semantic Similarity
1	Dermatofibrosarcoma	35.4%
2	Dermatofibrosarcoma Protuberans	35.4%
3	Chondrosarcoma	31.6%
4	synovial sarcoma	31.6%
5	Clear Cell Sarcoma of Soft Tissue	31.6%
6	leiomyosarcoma	27%
7	liposarcoma	27%
8	Alveolar Soft Part Sarcoma	27%
9	Malignant Fibrous Histiocytoma	26.6%
10	Carcinosarcoma	26.3%
11	Hemangiosarcoma	26.3%
12	lymphangiosarcoma	26.3%
13	Osteosarcoma	25.9%
14	Neuroectodermal Tumors	24.5%
15	Meningioma	22.1%
16	Sarcoma, Myeloid	22%
17	Angiomyolipoma	21.6%
18	leukemia	21.4%
19	Neoplasms, Germ Cell and Embryonal	21.4%
20	Neoplasms, Glandular and Epithelial	21.4%
21	Germ Cell Cancer	21.4%
22	Neoplasms, Neuroepithelial	21.3%
23	Gliomatosis cerebri	21.3%
24	Carcinoma 256, Walker	19.8%
25	Sarcoma, Experimental	19.8%
26	Giant Cell Tumor of Bone	19.2%
27	Phyllodes Tumor	18.9%
28	Desmoplastic Small Round Cell Tumor	18.9%
29	Histiocytic Disorders, Malignant	18.4%
30	Myxoma	17.9%
31	Neoplasms, Bone Tissue	17.9%
32	Chondroma	17.9%
33	Enchondroma	17.9%
34	fibroma	17.5%
35	Fibromatosis	17.5%
36	Rhabdomyosarcoma	17.4%
37	melanoma	16.8%
38	Neuroma	16.3%
39	Adenofibroma	16.2%
40	Fibroadenoma	16.2%
41	Lymphoma	16.2%
42	Neurilemmoma	16.1%
43	Endometrial Stromal Sarcoma	15.9%
44	Composite Lymphoma	15.5%
45	Craniopharyngioma	14.3%
46	Neuroectodermal Tumor, Melanotic	14.3%
47	Neuroendocrine Tumors	14.3%
48	Trophoblastic Neoplasms	14.2%
49	Leukemia, Experimental	14.2%
50	Sarcoma 180	13.9%
51	Hamartoma	13.9%
52	Neoplasms, Hormone-Dependent	13.9%
53	Neoplasms, Multiple Primary	13.9%
54	Paraneoplastic Syndromes	13.9%
55	Precancerous Conditions	13.9%
56	Neoplasms, Second Primary	13.9%
57	Leukemia, Plasma Cell	13.8%
58	Mastocytosis	13.7%
59	Gastrointestinal Stromal Tumors	13.6%
60	Medulloblastoma	13.4%
61	Tuberous Sclerosis	13.3%
62	Adenoma, Acidophil	13.2%
63	Ganglioneuroma	13.2%
64	Glioma	13.2%
65	Malignant Glioma	13.2%
66	Melanoma, Experimental	13.2%
67	Lymphangioleiomyomatosis	12.9%
68	Leukemia, Radiation-Induced	12.7%
69	Alveolar rhabdomyosarcoma	12.6%
70	Lipoma	12.6%
71	Myoma	12.6%
72	Angiolipoma	12.6%
73	Myelolipoma	12.6%
74	Smooth Muscle Tumor	12.6%
75	Complex Regional Pain Syndromes	12.5%
76	Sarcoma	12.4%
77	Motor Neuron Disease	12.1%
78	Fibromatosis, Aggressive	12.1%
79	Fibromatosis, Abdominal	12.1%
80	Cyst	12%
81	Neoplastic Processes	12%
82	Neoplastic Syndromes, Hereditary	12%
83	Pregnancy Complications, Neoplastic	12%
84	Paraneoplastic Encephalomyelitis	12%
85	Carcinoma, Ehrlich Tumor	12%
86	Dermoid Cyst	12%
87	Carcinoma, Lewis Lung	12%
88	Neoplasms, Experimental	11.9%
89	Basal cell carcinoma	11.6%
90	Carcinoma, Papillary	11.6%
91	Squamous cell carcinoma	11.6%
92	Cystadenoma	11.6%
93	Mesothelioma	11.6%
94	Carcinoma, Basal Cell	11.6%
95	Central Nervous System Neoplasms	11.6%
96	Adenoma	11.6%
97	Ameloblastoma	11.6%
98	Angiokeratoma	11.6%
99	Carcinoma	11.6%
100	Chordoma	11.6%
101	Hemangioma	11.6%
102	hemangiopericytoma	11.6%
103	Lymphangioma	11.6%
104	Mesenchymoma	11.6%
105	Nevus	11.6%
106	Teratoma	11.6%
107	Hepatoblastoma	11.6%
108	Mixed Tumor, Mullerian	11.6%
109	Germinoma	11.6%
110	Teratocarcinoma	11.6%
111	Angiofibroma	11.6%
112	Epithelioma	11.6%
113	Carcinoid Tumor	11.4%
114	Stiff-Person Syndrome	11.2%
115	Osteoblastoma	11.2%
116	Osteoma	11.2%
117	Chondromatosis	11.2%
118	Multiple Endocrine Neoplasia	11.2%
119	Peripheral Nerve Injuries	11.1%
120	Hutchinson's Melanotic Freckle	11%
121	Melanoma, Amelanotic	11%
122	Guillain-Barre Syndrome	11%
123	Acoustic Neuroma	10.7%
124	Fibrosarcoma	10.5%
125	Neoplasms, Radiation-Induced	10.5%
126	Thymoma	10.4%
127	Nervous System Neoplasms	10.2%
128	Lambert-Eaton Myasthenic Syndrome	10.2%
129	Retinoblastoma	10.1%
130	Causalgia	10.1%
131	Polyradiculoneuropathy	10.1%
132	Polyradiculoneuritis	10.1%
133	Choriocarcinoma	10%
134	Carcinoma, Lobular	10%
135	Optic Nerve Glioma	10%
136	Plasmacytoma	10%
137	Malignant histiocytosis	9.9%
138	Histiocytic sarcoma	9.9%
139	Neuritis	9.7%
140	Polyneuritis	9.7%
141	Radiculitis	9.7%
142	Polyneuropathy	9.7%
143	Mononeuritis	9.7%
144	Mononeuropathies	9.7%
145	Brachial Plexus Neuropathies	9.7%
146	Radiculopathy	9.7%
147	Mononeuropathy Multiplex	9.7%
148	Nerve Root Compression	9.7%
149	Mastocytoma	9.7%
150	Mastocytosis, Systemic	9.6%
151	Cystadenocarcinoma	9.5%
152	Mucoepidermoid Carcinoma	9.5%
153	Nephroblastoma	9.4%
154	Brachial Plexus Neuritis	9.3%
155	Neuralgic Amyotrophy	9.3%
156	Dupuytren Contracture	9.3%
157	Paraganglioma	9.3%
158	Neuromuscular Junction Diseases	9.3%
159	Cranial nerve diseases	9.2%
160	Demyelinating Diseases	9.2%
161	Demyelination	9.2%
162	Chronobiology Disorders	9.2%
163	Astrocytoma	9.2%
164	Ependymoma	9.2%
165	oligodendroglioma	9.2%
166	Ganglioglioma	9.2%
167	gliosarcoma	9.2%
168	Anaplastic astrocytoma	9.2%
169	Anaplastic Oligodendroglioma	9.2%
170	Leukemia L1210	9.1%
171	Leukemia P388	9.1%
172	Acanthoma	9.1%
173	Sturge-Weber Syndrome	8.7%
174	Hodgkin Disease	8.7%
175	Lymphoma, Non-Hodgkin	8.7%
176	Isaacs syndrome	8.4%
177	Acrodynia	8.4%
178	Diabetic Neuropathies	8.4%
179	Diabetic Amyotrophy	8.4%
180	Diabetic Autonomic Neuropathy	8.4%
181	Neuralgia	8.3%
182	Neuropathic pain	8.3%
183	Mammary Neoplasms, Experimental	8.3%
184	Malignant Carcinoid Syndrome	8.3%
185	Myopathy	8.2%
186	Central Nervous System Cysts	8.2%
187	Chronic Fatigue Syndrome	8.2%
188	Poliomyelitis	8.2%
189	Trauma, Nervous System	8.1%
190	Rhabdomyoma	8%
191	Restless Legs Syndrome	8%
192	Neurologic Manifestations	8%
193	Neurotoxicity Syndromes	8%
194	Neoplasms, Fibrous Tissue	7.9%
195	Primary amyloidosis	7.8%
196	Myelitis, Transverse	7.8%
197	Opsoclonus-Myoclonus Syndrome	7.7%
198	Lymphomatoid Granulomatosis	7.7%
199	Amyotrophic Lateral Sclerosis	7.6%
200	Hand-Arm Vibration Syndrome	7.6%
201	Multiple System Atrophy	7.6%
202	Spinal Muscular Atrophy	7.6%
203	Progressive Muscular Atrophy	7.6%
204	Brain Neoplasms	7.5%
205	Spinal Cord Neoplasms	7.5%
206	Basal Cell Nevus Syndrome	7.5%
207	Tarsal Tunnel Syndrome	7.5%
208	Cauda Equina Syndrome	7.5%
209	Bowen's Disease	7.5%
210	Ocular Motility Disorders	7.4%
211	Cyclophoria	7.4%
212	Myasthenia Gravis	7.3%
213	Subacute Combined Degeneration	7.3%
214	Glioblastoma	7.2%
215	Neuroblastoma	7.2%
216	Glioblastoma Multiforme	7.2%
217	Abdominal Neoplasms	7.1%
218	Erythroplasia	7.1%
219	Follicular cyst	7.1%
220	Head and Neck Neoplasms	7.1%
221	Mucocele	7.1%
222	Pilonidal Cyst	7.1%
223	Soft Tissue Neoplasms	7.1%
224	Thoracic Neoplasms	7.1%
225	Thyroglossal Cyst	7.1%
226	Synovial Cyst	7.1%
227	Aberrant Crypt Foci	7.1%
228	Neurofibrosarcoma	7.1%
229	Mesoblastic Nephroma	7.1%
230	Sleep Wake Disorders	7.1%
231	Limbic Encephalitis	7%
232	Reflex Sympathetic Dystrophy	6.8%
233	Miller Fisher Syndrome	6.8%
234	Paraneoplastic Cerebellar Degeneration	6.8%
235	Pheochromocytoma	6.8%
236	Adenocarcinoma	6.7%
237	Carcinoma in Situ	6.7%
238	Carcinoma, Transitional Cell	6.7%
239	Dysgerminoma	6.7%
240	Hemangioendothelioma	6.7%
241	Papilloma	6.7%
242	Pseudomyxoma Peritonei	6.7%
243	Seminoma	6.7%
244	Papillomatosis	6.7%
245	Adenomatosis, Pulmonary	6.7%
246	Adenomatous Polyps	6.7%
247	Carcinoma, Large Cell	6.7%
248	Carcinoma, Small Cell	6.7%
249	Carpal Tunnel Syndrome	6.6%
250	Ophthalmoplegic Migraine	6.6%
251	Sciatica	6.5%
252	Botulism	6.5%
253	Progressive bulbar palsy	6.4%
254	Bulbar palsy	6.4%
255	Waldenstrom Macroglobulinemia	6.4%
256	Multiple Myeloma	6.4%
257	Meningeal Neoplasms	6.4%
258	Digestive System Neoplasms	6.3%
259	Endocrine Gland Neoplasms	6.3%
260	Eye Neoplasms	6.3%
261	Encephalomyelitis	6.2%
262	Prion Diseases	6.2%
263	Autonomic Dysreflexia	6.2%
264	Ganglioneuroblastoma	6.2%
265	Bone neoplasms	6.2%
266	Leukoplakia	6.2%
267	Lymphocele	6.2%
268	Pancreatic Cyst	6.2%
269	Skin Neoplasms	6.2%
270	Hematologic Neoplasms	6.2%
271	Barrett Esophagus	6.1%
272	Breast Cyst	6.1%
273	Actinic keratosis	6.1%
274	Mediastinal Cyst	6.1%
275	Neoplasm Invasiveness	6.1%
276	Neoplasm Metastasis	6.1%
277	Neoplasm Recurrence, Local	6.1%
278	Parovarian Cyst	6.1%
279	Pericardial Cyst	6.1%
280	Splenic Neoplasms	6.1%
281	Thymic Cyst	6.1%
282	Carcinogenesis	6.1%
283	Myxoid cyst	6.1%
284	Metastasis	6.1%
285	Carcinoma, Pancreatic Ductal	6.1%
286	Carcinoid Heart Disease	6.1%
287	Hepatocellular Adenoma	6.1%
288	Multiple Endocrine Neoplasia Type 1	6%
289	Urticaria Pigmentosa	6%
290	Prolactinoma	5.9%
291	Growth Hormone-Secreting Pituitary Adenoma	5.9%
292	Leukemia, Myelomonocytic, Chronic	5.8%
293	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	5.8%
294	Liver Neoplasms, Experimental	5.7%
295	Spinal Cord Injuries	5.6%
296	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	5.6%
297	Asterixis	5.5%
298	Ballismus	5.5%
299	Sciatic Neuropathy	5.4%
300	Ulnar Neuropathies	5.4%
301	Lesion of Sciatic Nerve	5.4%
302	Ulnar Neuritis	5.4%
303	Radial nerve compression	5.4%
304	Radial Tunnel Syndrome	5.4%
305	Peroneal Neuropathies	5.4%
306	Radial Neuropathy	5.4%
307	Median Neuropathy	5.4%
308	Sciatic Nerve Palsy	5.4%
309	Femoral Neuropathy	5.4%
310	Tibial Neuropathy	5.4%
311	Ulnar Nerve Palsy	5.4%
312	Radial nerve palsy	5.4%
313	Adenomatous Polyposis Coli	5.4%
314	Meningoencephalitis	5.4%
315	Corpus Luteum Cyst	5.4%
316	Ovarian Cysts	5.4%
317	Neuritis, Autoimmune, Experimental	5.3%
318	Parkinson Disease	5.3%
319	Marchiafava-Bignami Disease	5.3%
320	Parathyroid Neoplasms	5.3%
321	Peritoneal Neoplasms	5.3%
322	Thyroid Neoplasm	5.3%
323	Thyroid carcinoma	5.3%
324	Lewy Body Disease	5.2%
325	Dandy-Walker Syndrome	5.1%
326	Pneumocephalus	5.1%
327	Hemangioma, Cavernous	5.1%
328	Leukemia, T-Cell	5.1%
329	Leukemia, B-Cell	5.1%
330	Lymphoma, Follicular	5.1%
331	T-Cell Lymphoma	5.1%
332	Mantle cell lymphoma	5.1%
333	Sleep Disorders, Circadian Rhythm	5%
334	Hydatidiform Mole	5%
335	Cubital Tunnel Syndrome	5%
336	granulosa cell tumor	4.9%
337	Carcinoma, Ovarian Epithelial	4.9%
338	Dyskinesia, Drug-Induced	4.8%
339	Choledochal Cyst	4.8%
340	Pancreatic Neoplasm	4.8%
341	Progressive supranuclear palsy	4.8%
342	Peutz-Jeghers Syndrome	4.8%
343	Thoracic Outlet Syndrome	4.7%
344	Brain Diseases	4.7%
345	Dysautonomia	4.7%
346	Meningitis	4.7%
347	Movement Disorders	4.7%
348	Pachymeningitis	4.7%
349	Spinal Cord Diseases	4.7%
350	Vagus Nerve Disorder	4.7%
351	Glossopharyngeal Neuralgia	4.7%
352	Abducens Nerve Diseases	4.7%
353	Heavy Metal Poisoning, Nervous System	4.7%
354	Tauopathies	4.7%
355	Trochlear Nerve Diseases	4.7%
356	Neuromuscular Diseases	4.7%
357	Neuroleptic Malignant Syndrome	4.7%
358	Myelinolysis, Central Pontine	4.7%
359	Vipoma	4.6%
360	Supratentorial Neoplasms	4.5%
361	Leukoencephalitis, Acute Hemorrhagic	4.4%
362	Akathisia, Drug-Induced	4.4%
363	Charcot-Marie-Tooth Disease	4.4%
364	Neuromyelitis Optica	4.4%
365	Epidural Abscess	4.4%
366	Olfactory Nerve Injuries	4.4%
367	Myelitis	4.4%
368	Adenoid Cystic Carcinoma	4.4%
369	Adenocarcinoma, Clear Cell	4.4%
370	Cholangiocarcinoma	4.4%
371	Cervical Intraepithelial Neoplasia	4.4%
372	Hemangioblastoma	4.4%
373	Lymphoma, Extranodal NK-T-Cell	4.4%
374	Myasthenia Gravis, Autoimmune, Experimental	4.3%
375	Myositis	4.3%
376	Myotonic Disorders	4.3%
377	Myasthenic Syndromes, Congenital	4.3%
378	Striatonigral Degeneration	4.3%
379	MPTP Poisoning	4.2%
380	Tracheal Neoplasms	4.2%
381	neurofibroma	4.2%
382	Central Nervous System Infection	4.2%
383	Optic Neuropathy	4.2%
384	Horner Syndrome	4.1%
385	Denys-Drash Syndrome	4.1%
386	Leukoplakia, Oral	4.1%
387	Facial Nerve Diseases	4.1%
388	Craniocerebral Trauma	4.1%
389	Parasomnia	4.1%
390	Dyssomnias	4.1%
391	Pituitary Adenoma	4.1%
392	Pituitary Neoplasms	4.1%
393	Vestibulocochlear Nerve Diseases	4.1%
394	Decerebrate State	4.1%
395	Hemiparesis	4.1%
396	Hydranencephaly	4.1%
397	Meningism	4.1%
398	Neural Tube Defects	4.1%
399	Paresis	4.1%
400	Seizures	4.1%
401	Sensation Disorders	4.1%
402	Tethered Cord Syndrome	4.1%
403	Complex partial seizures	4.1%
404	Iniencephaly	4.1%
405	Craniorachischisis	4.1%
406	Exencephaly	4.1%
407	Monoparesis	4.1%
408	Septo-Optic Dysplasia	4.1%
409	Cortical Dysplasia	4.1%
410	Neurogenic Inflammation	4.1%
411	Gait Disorders, Neurologic	4.1%
412	Neuromuscular Manifestations	4.1%
413	Malformations of Cortical Development	4.1%
414	Sweating, Gustatory	4%
415	Auriculotemporal Syndrome	4%
416	Encephalomyelitis, Acute Disseminated	4%
417	Amyloid Neuropathies, Familial	4%
418	insulinoma	4%
419	Facial Nerve Injuries	4%
420	Nasopharyngeal carcinoma	3.9%
421	Retroperitoneal Neoplasms	3.9%
422	Meningeal Carcinomatosis	3.9%
423	Shy-Drager Syndrome	3.9%
424	Brain Injuries	3.8%
425	Multiple Sclerosis	3.8%
426	Leukoencephalopathy, Progressive Multifocal	3.8%
427	Fibromyalgia	3.8%
428	Medial Tibial Stress Syndrome	3.8%
429	Mitochondrial Myopathies	3.8%
430	Vasculitis, Central Nervous System	3.7%
431	Eosinophilia-Myalgia Syndrome	3.7%
432	Jet Lag Syndrome	3.7%
433	Leukemia, Myeloid, Chronic-Phase	3.7%
434	Esophageal Neoplasms	3.7%
435	Dystonia Musculorum Deformans	3.7%
436	POEMS Syndrome	3.7%
437	Pupil Disorders	3.6%
438	Neurobehavioral Manifestations	3.6%
439	Cerebellar Neoplasms	3.6%
440	Myotonia Congenita	3.6%
441	Myotonic Dystrophy	3.6%
442	Uveomeningoencephalitic Syndrome	3.6%
443	Vertigo	3.5%
444	Alcohol-Induced Disorders, Nervous System	3.5%
445	Adrenocortical carcinoma	3.5%
446	Leydig Cell Tumor	3.4%
447	Brain Abscess	3.4%
448	Ophthalmoplegia	3.4%
449	External Ophthalmoplegia	3.4%
450	Subdural Effusion	3.4%
451	Parkinsonian Disorders	3.4%
452	Nocturnal Myoclonus Syndrome	3.4%
453	Testicular Neoplasms	3.4%
454	Mouth Neoplasms	3.4%
455	Vascular Neoplasms	3.4%
456	Thymus Neoplasms	3.4%
457	Xeroderma Pigmentosum	3.3%
458	Familial Periodic Paralysis	3.3%
459	Gastrinoma	3.3%
460	Glucagonoma	3.3%
461	Genital Neoplasms, Female	3.3%
462	Pancreatic Pseudocyst	3.3%
463	Lymphatic Metastasis	3.3%
464	Neoplasms, Unknown Primary	3.3%
465	Leukemic Infiltration	3.3%
466	Breast Neoplasms, Male	3.3%
467	Neoplasm Micrometastasis	3.3%
468	Triple Negative Breast Neoplasms	3.3%
469	Polyradiculopathy	3.3%
470	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	3.3%
471	Leukemia, Large Granular Lymphocytic	3.3%
472	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	3.3%
473	Lymphoma, T-Cell, Cutaneous	3.3%
474	Lymphoma, AIDS-Related	3.3%
475	Enteropathy-Associated T-Cell Lymphoma	3.3%
476	Primary Effusion Lymphoma	3.3%
477	Huntington Disease	3.2%
478	Voice Disorders	3.2%
479	Voice Disturbance	3.2%
480	Renal Cell Carcinoma	3.2%
481	Papillary Renal Cell Carcinoma	3.2%
482	Smith-Magenis syndrome	3.2%
483	Alstrom Syndrome	3.2%
484	Klatskin Tumor	3.2%
485	Dural Arteriovenous Fistula	3.2%
486	Lupus Vasculitis, Central Nervous System	3.1%
487	Vocal Cord Paralysis	3.1%
488	Refsum Disease	3.1%
489	Canavan Disease	3.1%
490	Alexander Disease	3.1%
491	Ataxia Telangiectasia	3.1%
492	Scrapie	3%
493	Central Cord Syndrome	3%
494	Thyroid Nodule	3%
495	Presenile dementia	3%
496	Senile dementia	3%
497	Meningitis, Bacterial	3%
498	Meningitis, Fungal	3%
499	Chorea	3%
500	Myalgia	3%
501	Adrenal Gland Neoplasms	3%
502	Gastrointestinal Neoplasms	3%
503	Genital Neoplasms, Male	3%
504	Liver neoplasms	3%
505	Uveal Neoplasms	3%
506	Brain Stem Neoplasms	3%
507	Carcinoma, Endometrioid	3%
508	Urologic Neoplasms	2.9%
509	Epilepsy, Post-Traumatic	2.9%
510	Sebaceous Gland Neoplasms	2.9%
511	Spinal Neoplasms	2.9%
512	Bone Marrow Neoplasms	2.9%
513	Polycystic Ovary Syndrome	2.9%
514	Hepatolenticular Degeneration	2.8%
515	Reflex, Abnormal	2.8%
516	Hyporeflexia	2.8%
517	Hyperreflexia	2.8%
518	Alcohol Withdrawal Seizures	2.8%
519	Amblyopia	2.7%
520	Cerebrospinal Fluid Otorrhea	2.7%
521	Cerebrospinal Fluid Rhinorrhea	2.7%
522	Gait Ataxia	2.7%
523	Burkitt Lymphoma	2.6%
524	Mitochondrial Encephalomyopathies	2.6%
525	Dementia, Vascular	2.5%
526	Akinetic Mutism	2.5%
527	Anoxic Encephalopathy	2.5%
528	Arachnoiditis	2.5%
529	Basal Ganglia Diseases	2.5%
530	Brain Damage, Chronic	2.5%
531	Cerebellar Diseases	2.5%
532	Encephalitis	2.5%
533	Encephalomalacia	2.5%
534	Epilepsy	2.5%
535	Hydrocephalus	2.5%
536	Congenital Hydrocephalus	2.5%
537	Hypothalamic Diseases	2.5%
538	Aseptic Meningitis	2.5%
539	Syringomyelia	2.5%
540	Thalamic Diseases	2.5%
541	Intracranial Hypertension	2.5%
542	Aura	2.5%
543	Leukoencephalopathy	2.5%
544	Essential Tremor	2.5%
545	Neuroaxonal Dystrophies	2.5%
546	Familial Tremor	2.5%
547	Headache Disorders	2.5%
548	Intracranial Hypotension	2.5%
549	Brain Edema	2.5%
550	Brain Hypoxia	2.5%
551	Aqueductal Stenosis	2.5%
552	Pneumorrhachis	2.5%
553	Writer's Cramp	2.5%
554	Brain Hemorrhage, Traumatic	2.5%
555	Meige Syndrome	2.5%
556	Cerebral Ventriculitis	2.5%
557	Peripheral Nervous System Diseases	2.4%
558	Akathisia	2.4%
559	Restlessness	2.4%
560	Psychomotor Agitation	2.4%
561	Carotid Artery Injuries	2.4%
562	Brain Death	2.4%
563	Coma, Post-Head Injury	2.4%
564	Polymyositis	2.4%
565	Lafora Disease	2.4%
566	Unverricht-Lundborg Syndrome	2.4%
567	Mycosis Fungoides	2.4%
568	Lymphomatoid Papulosis	2.4%
569	Plasmablastic lymphoma	2.4%
570	ovarian neoplasm	2.4%
571	Nose Neoplasms	2.3%
572	Friedreich Ataxia	2.3%
573	Choroid Plexus Papilloma	2.2%
574	Creutzfeldt-Jakob disease	2.2%
575	Basal Ganglia Cerebrovascular Disease	2.2%
576	Brain Diseases, Metabolic	2.2%
577	Cerebrovascular Disorders	2.2%
578	Optic Atrophy	2.2%
579	Optic Neuritis	2.2%
580	Papilledema	2.2%
581	Strabismus	2.2%
582	Tolosa-Hunt Syndrome	2.2%
583	Cerebrovascular Insufficiency	2.2%
584	Arsenic Poisoning	2.2%
585	Dementia	2.2%
586	Central Nervous System Fungal Infections	2.2%
587	Conus Medullaris Syndrome	2.2%
588	Spinal Cord Vascular Diseases	2.2%
589	Brain Injuries, Diffuse	2.2%
590	Traumatic Brain Injury	2.2%
591	Cerebellar Ataxia	2.2%
592	Torticollis	2.2%
593	Multiple Sclerosis, Chronic Progressive	2.2%
594	Multiple Sclerosis, Relapsing-Remitting	2.2%
595	Facial Injuries	2.2%
596	Facial Neuralgia	2.2%
597	Sleep Talking	2.2%
598	Manganese Poisoning	2.2%
599	Sleep Disorders, Intrinsic	2.2%
600	Orthostatic intolerance	2.2%
601	Anosmia	2.2%
602	Ataxia	2.2%
603	Athetosis	2.2%
604	Catalepsy	2.2%
605	Dystonia	2.2%
606	Hemiplegia	2.2%
607	Locked-In Syndrome	2.2%
608	Meningomyelocele	2.2%
609	Muscle Hypertonia	2.2%
610	Muscle hypotonia	2.2%
611	Myoclonus	2.2%
612	Myotonia	2.2%
613	Paraplegia	2.2%
614	Pseudobulbar Palsy	2.2%
615	Quadriplegia	2.2%
616	Spasm	2.2%
617	Spastic Paraplegia	2.2%
618	Status Epilepticus	2.2%
619	Taste Disorders	2.2%
620	Tremor	2.2%
621	Spina Bifida	2.2%
622	Monoplegia	2.2%
623	Hypokinesia	2.2%
624	Paraparesis	2.2%
625	Bradykinesia	2.2%
626	Waxy flexibility	2.2%
627	Action Tremor	2.2%
628	Resting Tremor	2.2%
629	Dysosmia	2.2%
630	Quadriparesis	2.2%
631	Mercury Poisoning, Nervous System	2.2%
632	Olfaction Disorders	2.2%
633	Myokymia	2.2%
634	Lead Poisoning, Nervous System	2.2%
635	Vestibular Neuronitis	2.2%
636	Somatosensory Disorders	2.2%
637	Hyperkinesia	2.2%
638	Intention tremor	2.2%
639	Muscular Dystrophy	2.1%
640	Orbital Myositis	2.1%
641	Pyomyositis	2.1%
642	Vertebral Artery Dissection	2.1%
643	Amnesia, Transient Global	2.1%
644	Gait Apraxia	2.1%
645	Palatal Neoplasms	2%
646	Posterior Leukoencephalopathy Syndrome	2%
647	Posterior reversible encephalopathy syndrome	2%
648	Tuberculosis, Meningeal	2%
649	Leukomalacia, Periventricular	2%
650	Alice in Wonderland Syndrome	2%
651	Zollinger-Ellison syndrome	2%
652	Vision Disorders	2%
653	Metamorphopsia	2%
654	Visual Impairment	2%
655	Optic Neuropathy, Ischemic	1.9%
656	Anterior Ischemic Optic Neuropathy	1.9%
657	Central Nervous System Bacterial Infections	1.9%
658	Toxoplasmosis, Cerebral	1.9%
659	Facial Hemiatrophy	1.9%
660	Melkersson-Rosenthal Syndrome	1.9%
661	Anisocoria	1.9%
662	Confusion	1.9%
663	Facial paralysis	1.9%
664	Lethargy	1.9%
665	Memory Disorders	1.9%
666	Muscle Cramp	1.9%
667	Perceptual Disorders	1.9%
668	Psychomotor Disorders	1.9%
669	Tonic Pupil	1.9%
670	Anhedonia	1.9%
671	Disorientation	1.9%
672	Facial Paresis	1.9%
673	Memory Loss	1.9%
674	Hemisensory Neglect	1.9%
675	Dysacusis	1.9%
676	Sleep Bruxism	1.9%
677	Sezary Syndrome	1.9%
678	Anencephaly	1.9%
679	Meningocele	1.9%
680	Muscular Atrophy	1.9%
681	Respiratory Paralysis	1.9%
682	Encephalocele	1.9%
683	Tetany	1.9%
684	Hypokalemic periodic paralysis	1.9%
685	Brain Concussion	1.8%
686	Vascular Headaches	1.8%
687	Hypoxia-Ischemia, Brain	1.8%
688	Tardive Dyskinesia	1.8%
689	Persistent Vegetative State	1.8%
690	Giant Cell Arteritis	1.7%
691	Temporal Arteritis	1.7%
692	Ear Neoplasms	1.7%
693	Eyelid Neoplasms	1.7%
694	Lung Neoplasms	1.7%
695	Pleural Neoplasms	1.7%
696	Duane Retraction Syndrome	1.7%
697	Consciousness Disorders	1.7%
698	Mental Retardation	1.7%
699	Muscle Weakness	1.7%
700	Depressed Level of Consciousness	1.7%
701	Mental deficiency	1.7%
702	Intellectual Disability	1.7%
703	Mobius Syndrome	1.7%
704	Bell Palsy	1.7%
705	Adrenoleukodystrophy	1.7%
706	Catatonia	1.7%
707	Herpes Zoster Oticus	1.7%
708	Cell Transformation, Viral	1.7%
709	Salivary Gland Neoplasms	1.7%
710	Tongue Neoplasms	1.7%
711	Aphonia	1.7%
712	Sleep Deprivation	1.7%
713	Dysphonia	1.7%
714	Uterine Neoplasms	1.7%
715	Vaginal Neoplasms	1.7%
716	Vulvar Neoplasms	1.7%
717	Uterine Cancer	1.7%
718	Fallopian Tube Neoplasms	1.7%
719	Auditory Perceptual Disorders	1.6%
720	Meningitis, Cryptococcal	1.6%
721	Meningitis, Listeria	1.6%
722	Meningitis, Haemophilus	1.6%
723	Meningitis, Pneumococcal	1.6%
724	Frontotemporal dementia	1.6%
725	Myoclonic Epilepsy	1.6%
726	Epilepsy, Temporal Lobe	1.6%
727	Epilepsy, Rolandic	1.6%
728	Benign Rolandic Epilepsy	1.6%
729	Pharyngeal Neoplasms	1.6%
730	MELAS Syndrome	1.5%
731	Bile Duct Neoplasms	1.5%
732	gallbladder neoplasm	1.5%
733	Intestinal Neoplasms	1.5%
734	Penile Neoplasms	1.5%
735	Prostatic Neoplasms	1.5%
736	Stomach Neoplasms	1.5%
737	Neuronal Ceroid-Lipofuscinoses	1.5%
738	Polycythemia Vera	1.5%
739	Cerebral Palsy	1.5%
740	Epilepsies, Partial	1.5%
741	Epilepsy, Generalized	1.5%
742	Pseudotumor Cerebri	1.5%
743	Hypertensive Encephalopathy	1.5%
744	Simple Partial Seizures	1.5%
745	Epilepsy, Reflex	1.5%
746	Postural Orthostatic Tachycardia Syndrome	1.5%
747	Headache Disorders, Primary	1.5%
748	Headache Disorders, Secondary	1.5%
749	Medication overuse headache	1.5%
750	Kearns-Sayre syndrome	1.4%
751	Classical Lissencephalies and Subcortical Band Heterotopias	1.4%
752	Aicardi's syndrome	1.4%
753	Laryngeal neoplasm	1.4%
754	Hoarseness	1.4%
755	Cockayne Syndrome	1.4%
756	Alcohol Withdrawal Delirium	1.4%
757	Subarachnoid Hemorrhage, Traumatic	1.4%
758	Carotid Artery, Internal, Dissection	1.4%
759	Diffuse Axonal Injury	1.4%
760	Basal Ganglia Hemorrhage	1.4%
761	Bladder Neoplasm	1.4%
762	Kidney Neoplasm	1.4%
763	Ureteral Neoplasms	1.4%
764	Urethral Neoplasms	1.4%
765	Nelson Syndrome	1.3%
766	Welander Distal Myopathy	1.3%
767	Pituitary Diseases	1.3%
768	Holoprosencephaly	1.3%
769	Subacute Sclerosing Panencephalitis	1.3%
770	Carotid Artery Diseases	1.3%
771	Brain Ischemia	1.3%
772	Esotropia	1.3%
773	Exotropia	1.3%
774	Hypotension, Orthostatic	1.3%
775	Sleep Apnea Syndromes	1.3%
776	Cerebrovascular accident	1.3%
777	Kluver-Bucy Syndrome	1.3%
778	Vasospasm, Intracranial	1.3%
779	Spinal Cord Ischemia	1.3%
780	Intracranial Arterial Diseases	1.3%
781	Post-Exercise Hypotension	1.3%
782	Disorders of Excessive Somnolence	1.3%
783	Sleep Initiation and Maintenance Disorders	1.3%
784	Pituitary Apoplexy	1.3%
785	Night Terrors	1.3%
786	Somnambulism	1.3%
787	Trigeminal Nerve Disorder	1.3%
788	Transient Insomnia	1.3%
789	Sleep Paralysis	1.3%
790	Chronic Insomnia	1.3%
791	REM Sleep Behavior Disorder	1.3%
792	Hypersomnia	1.3%
793	Dermal Sinus	1.2%
794	Dysgeusia	1.2%
795	Formication	1.2%
796	Hyperalgesia	1.2%
797	Hyperesthesia	1.2%
798	Hypesthesia	1.2%
799	Language Disorders	1.2%
800	Numbness	1.2%
801	Paresthesia	1.2%
802	Paraparesis, Spastic	1.2%
803	Spina Bifida Cystica	1.2%
804	Trismus	1.2%
805	Spina Bifida Occulta	1.2%
806	Epilepsia Partialis Continua	1.2%
807	Hypogeusia	1.2%
808	Brown-Sequard Syndrome	1.2%
809	Lissencephaly	1.2%
810	Polymicrogyria	1.2%
811	Pachygyria	1.2%
812	Schizencephaly	1.2%
813	Lockjaw	1.2%
814	Allodynia	1.2%
815	Lead Poisoning, Nervous System, Childhood	1.2%
816	Lead Poisoning, Nervous System, Adult	1.2%
817	Periventricular Nodular Heterotopia	1.2%
818	Ageusia	1.2%
819	Tuberculosis, Central Nervous System	1.2%
820	Brain Contusion	1.2%
821	Brain Infarction	1.2%
822	Optic Atrophy, Hereditary, Leber	1.2%
823	Dermatomyositis	1.2%
824	Muscular Dystrophy, Duchenne	1.2%
825	Hematoma, Subdural	1.2%
826	Hematoma, Epidural, Cranial	1.2%
827	Juvenile Myoclonic Epilepsy	1.1%
828	Myoclonic Epilepsies, Progressive	1.1%
829	Eye Injuries	1.1%
830	Congenital nystagmus	1.1%
831	Alexia	1.1%
832	Dyslexia	1.1%
833	Bronchial Neoplasms	1.1%
834	Diplopia	1.1%
835	Muscle Rigidity	1.1%
836	Muscle Spasticity	1.1%
837	Scotoma	1.1%
838	Photophobia	1.1%
839	Cogwheel Rigidity	1.1%
840	Hemifacial Spasm	1.1%
841	Amaurosis	1.1%
842	Blindness	1.1%
843	Nuchal Rigidity	1.1%
844	Reye Syndrome	1.1%
845	Neuroaspergillosis	1.1%
846	Multiple Pulmonary Nodules	1.1%
847	Intracranial Embolism and Thrombosis	1.1%
848	Hepatic Encephalopathy	1.1%
849	Agnosia	1.1%
850	Apraxias	1.1%
851	Hallucinations	1.1%
852	Hemianopsia	1.1%
853	Hyperacusis	1.1%
854	Tinnitus	1.1%
855	Visual Agnosia	1.1%
856	Anosognosia	1.1%
857	Wernicke-Korsakoff Syndrome	1.1%
858	Phonophobia	1.1%
859	Hearing Loss	1.1%
860	Sarcopenia	1.1%
861	Endometrial Neoplasms	1.1%
862	Pseudorabies	1%
863	Putaminal Hemorrhage	1%
864	Amnesia	1%
865	Delirium	1%
866	Dissociative Amnesia	1%
867	Color blindness	1%
868	Global Amnesia	1%
869	Cri-du-Chat Syndrome	1%
870	Down Syndrome	1%
871	Brain Diseases, Metabolic, Inborn	1%
872	Trisomy 21	1%
873	Hypopharyngeal Neoplasms	1%
874	Pleural Effusion, Malignant	1%
875	Hypopharyngeal Cancer	1%
876	Williams Syndrome	1%
877	Microcephaly	1%
878	Macrocephaly	1%
879	Neurosyphilis	1%
880	Parotid Neoplasms	1%
881	Prostatic Neoplasms, Castration-Resistant	1%
882	Porencephaly	1%
883	Moyamoya Disease	1%
884	Infarction, Middle Cerebral Artery	0.9%
885	Infarction, Anterior Cerebral Artery	0.9%
886	Infarction, Posterior Cerebral Artery	0.9%
887	Post-Traumatic Headache	0.9%
888	Tension Headache	0.9%
889	Epilepsy, Complex Partial	0.9%
890	Migraine Disorders	0.9%
891	Abdominal Migraine	0.9%
892	Status Migrainosus	0.9%
893	Cervicogenic Headache	0.9%
894	Prader-Willi Syndrome	0.9%
895	Wernicke Encephalopathy	0.9%
896	AIDS Dementia Complex	0.9%
897	Cerebral Infarction	0.9%
898	Brain Stem Infarctions	0.9%
899	Phantom pain	0.9%
900	Phantom Limb Pain	0.9%
901	Cecal Neoplasms	0.9%
902	Duodenal Neoplasms	0.9%
903	Lyme Neuroborreliosis	0.9%
904	West Nile Fever	0.9%
905	Kernicterus	0.8%
906	Nasopharyngeal Neoplasms	0.8%
907	Empty Sella Syndrome	0.8%
908	Hyperpituitarism	0.8%
909	Hypopituitarism	0.8%
910	Hypophysitis	0.8%
911	Colorectal Neoplasms	0.8%
912	Cerebral Arterial Diseases	0.8%
913	Vertebrobasilar Insufficiency	0.8%
914	Anterior Spinal Artery Syndrome	0.8%
915	Basilar Artery Stenosis	0.8%
916	Vertebral Artery Stenosis	0.8%
917	Sleep Apnea, Obstructive	0.8%
918	Sleep Apnea, Central	0.8%
919	Intracranial Hemorrhage, Hypertensive	0.8%
920	Transient Cerebral Ischemia	0.8%
921	Narcolepsy	0.8%
922	Trigeminal Neuralgia	0.8%
923	Kleine-Levin Syndrome	0.8%
924	Hematoma, Subdural, Intracranial	0.8%
925	Hematoma, Subdural, Chronic	0.8%
926	Hematoma, Subdural, Acute	0.8%
927	Agraphia	0.8%
928	Anomia	0.8%
929	Cluttering	0.8%
930	Language Development Disorders	0.8%
931	Speech Disorders	0.8%
932	Syncope	0.8%
933	Stupor	0.8%
934	Dysgraphia	0.8%
935	Presyncope	0.8%
936	Dyslalia	0.8%
937	Menkes Kinky Hair Syndrome	0.7%
938	Paranasal Sinus Neoplasms	0.7%
939	Rubinstein-Taybi Syndrome	0.7%
940	Tonsillar Neoplasms	0.7%
941	Toxoplasmosis, Congenital	0.7%
942	Eye Burns	0.7%
943	Malaria, Cerebral	0.7%
944	Lateral Medullary Syndrome	0.7%
945	Carotid Stenosis	0.7%
946	Intracranial Aneurysm	0.7%
947	Neurocysticercosis	0.7%
948	Amaurosis Fugax	0.7%
949	Blindness, Cortical	0.7%
950	Dyscalculia	0.7%
951	Intracranial Arteriosclerosis	0.7%
952	Cerebral Atherosclerosis	0.7%
953	Rett Syndrome	0.7%
954	Subarachnoid Hemorrhage	0.7%
955	Cerebral Arteriosclerosis	0.7%
956	Cerebral Hemorrhage	0.7%
957	Cerebral Thrombosis	0.7%
958	Intracranial Embolism	0.7%
959	Intracranial Thrombosis	0.7%
960	Deafness	0.7%
961	Hearing Loss, Sudden	0.7%
962	Gerstmann Syndrome	0.7%
963	Hearing Loss, Bilateral	0.7%
964	Hearing Loss, High-Frequency	0.7%
965	Hearing Loss, Mixed Conductive-Sensorineural	0.7%
966	Prosopagnosia	0.7%
967	Apraxia, Ideomotor	0.7%
968	Charles Bonnet Syndrome	0.7%
969	Hearing Loss, Unilateral	0.7%
970	Complete Hearing Loss	0.7%
971	Alien Hand Syndrome	0.7%
972	Deaf Mutism	0.7%
973	Waterhouse-Friderichsen Syndrome	0.7%
974	Cluster Headache	0.7%
975	Migraine with Aura	0.7%
976	Familial Hemiplegic Migraine	0.7%
977	Chronic Paroxysmal Hemicrania	0.7%
978	SUNCT Syndrome	0.7%
979	Paroxysmal Hemicrania	0.7%
980	Radicular Cyst	0.6%
981	Appendiceal Neoplasms	0.6%
982	Colonic Neoplasms	0.6%
983	Rectal Neoplasms	0.6%
984	Corneal Scar	0.6%
985	Retrograde amnesia	0.6%
986	Amnesia, Anterograde	0.6%
987	Carotid Artery Thrombosis	0.6%
988	Hyperprolactinemia	0.6%
989	Subclavian Steal Syndrome	0.6%
990	Pick Disease of the Brain	0.6%
991	Cataplexy	0.6%
992	Aphasia	0.6%
993	Articulation Disorders	0.6%
994	Echolalia	0.6%
995	Stuttering	0.6%
996	Dysphasia	0.6%
997	Fragile X Syndrome	0.6%
998	Maxillary Sinus Neoplasms	0.5%
999	Fabry Disease	0.5%
1000	Galactosemias	0.5%
1001	Urea Cycle Disorders, Inborn	0.5%
1002	Tyrosinemias	0.5%
1003	Mutism	0.5%
1004	Selective Mutism	0.5%
1005	Acromegaly	0.5%
1006	Cerebral Amyloid Angiopathy	0.5%
1007	Sinus Thrombosis, Intracranial	0.5%
1008	Homocystinuria	0.5%
1009	Anus Neoplasms	0.5%
1010	Sigmoid Neoplasms	0.5%
1011	Leigh Disease	0.5%
1012	Dysarthria	0.5%
1013	Corneal Perforation	0.4%
1014	Mucopolysaccharidosis II	0.4%
1015	Alexia, Pure	0.4%
1016	Cavernous Sinus Thrombosis	0.4%
1017	Sagittal Sinus Thrombosis	0.4%
1018	Zellweger Syndrome	0.4%
1019	Carbamoyl-Phosphate Synthase I Deficiency Disease	0.3%
1020	Glycogen storage disease type II	0.3%
1021	Gaucher Disease	0.2%
1022	Niemann-Pick Disease, Type C	0.2%
1023	Tay-Sachs Disease	0.2%

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