MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Progressive bulbar palsy

(UMLS:C0030442)

Definition:: A motor neuron disease marked by progressive weakness of the muscles innervated by cranial nerves of the lower brain stem. Clinical manifestations include dysarthria, dysphagia, facial weakness, tongue weakness, and fasciculations of the tongue and facial muscles. The adult form of the disease is marked initially by bulbar weakness which progresses to involve motor neurons throughout the neuroaxis. Eventually this condition may become indistinguishable from AMYOTROPHIC LATERAL SCLEROSIS. Fazio-Londe syndrome is an inherited form of this illness which occurs in children and young adults. (Adams et al., Principles of Neurology, 6th ed, p1091; Brain 1992 Dec;115(Pt 6):1889-1900)
UMLS ID:: C0030442
MeSH ID:: D010244

Classification:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.574.562.300|C10.668.467.300

Synonym(s)

Progressive bulbar palsy

Bulbar palsy

Bulbar paralysis

PBP - Progressive bulbar palsy

Progressive Bulbar Palsy

bulbar palsy progressive

progressive bulbar palsy

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Riluzole	FAERS: 2 Canada Vigilance: 1	Canada Vigilance US FAERS
2	Fluoxetine	FAERS: 1	US FAERS
3	Levetiracetam	FAERS: 1	US FAERS
4	Methamphetamine	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Spinal Muscular Atrophy	48%
2	Progressive Muscular Atrophy	48%
3	Amyotrophic Lateral Sclerosis	41.7%
4	Neuromuscular Junction Diseases	27.3%
5	Tauopathies	27.3%
6	Peripheral Nervous System Diseases	27.3%
7	Prion Diseases	27.1%
8	Multiple System Atrophy	25.7%
9	Stiff-Person Syndrome	25%
10	Cranial nerve diseases	23.8%
11	Demyelinating Diseases	23.8%
12	Demyelination	23.8%
13	Chronobiology Disorders	23.8%
14	Complex Regional Pain Syndromes	23.7%
15	Parkinson Disease	23.3%
16	Myopathy	21.4%
17	Subacute Combined Degeneration	21.2%
18	Causalgia	21.1%
19	Polyradiculoneuropathy	20.3%
20	Polyradiculoneuritis	20.3%
21	Poliomyelitis	19.9%
22	Guillain-Barre Syndrome	19.8%
23	Brachial Plexus Neuritis	19.7%
24	Neuralgic Amyotrophy	19.7%
25	Lewy Body Disease	19.4%
26	Peripheral Nerve Injuries	19.2%
27	Myasthenia Gravis	18.9%
28	Chronic Fatigue Syndrome	18.8%
29	Trauma, Nervous System	18.5%
30	Lambert-Eaton Myasthenic Syndrome	18.4%
31	Striatonigral Degeneration	18%
32	Tarsal Tunnel Syndrome	18%
33	Cauda Equina Syndrome	18%
34	Nervous System Neoplasms	17.9%
35	Neurologic Manifestations	17.9%
36	Neurotoxicity Syndromes	17.9%
37	Neuritis	17.8%
38	Polyneuritis	17.8%
39	Radiculitis	17.8%
40	Polyneuropathy	17.8%
41	Mononeuritis	17.8%
42	Mononeuropathies	17.8%
43	Brachial Plexus Neuropathies	17.8%
44	Radiculopathy	17.8%
45	Mononeuropathy Multiplex	17.8%
46	Nerve Root Compression	17.8%
47	Ocular Motility Disorders	17.1%
48	Cyclophoria	17.1%
49	Encephalomyelitis	16.9%
50	Autonomic Dysreflexia	16.9%
51	Reflex Sympathetic Dystrophy	16.5%
52	Restless Legs Syndrome	16.5%
53	Paraneoplastic Encephalomyelitis	16.4%
54	Botulism	15.6%
55	Myotonia Congenita	15.5%
56	Shy-Drager Syndrome	15.5%
57	Miller Fisher Syndrome	15.4%
58	Dystonia Musculorum Deformans	15.4%
59	Meningoencephalitis	15.4%
60	Progressive supranuclear palsy	15.3%
61	Marchiafava-Bignami Disease	15.1%
62	Ophthalmoplegic Migraine	14.9%
63	Scrapie	14.8%
64	Presenile dementia	14.6%
65	Senile dementia	14.6%
66	Sleep Wake Disorders	14.5%
67	Myelitis, Transverse	14.5%
68	Acrodynia	14.4%
69	Carpal Tunnel Syndrome	14.4%
70	Sciatica	14.3%
71	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	14.2%
72	Spinal Cord Injuries	14.1%
73	Opsoclonus-Myoclonus Syndrome	14.1%
74	Charcot-Marie-Tooth Disease	14%
75	Myotonic Dystrophy	13.9%
76	Brain Diseases	13.6%
77	Dysautonomia	13.6%
78	Meningitis	13.6%
79	Movement Disorders	13.6%
80	Pachymeningitis	13.6%
81	Spinal Cord Diseases	13.6%
82	Vagus Nerve Disorder	13.6%
83	Glossopharyngeal Neuralgia	13.6%
84	Abducens Nerve Diseases	13.6%
85	Heavy Metal Poisoning, Nervous System	13.6%
86	Trochlear Nerve Diseases	13.6%
87	Myositis	13.6%
88	Isaacs syndrome	13.6%
89	Myotonic Disorders	13.6%
90	Myasthenic Syndromes, Congenital	13.6%
91	Asterixis	13.5%
92	Ballismus	13.5%
93	Dandy-Walker Syndrome	13.3%
94	Diabetic Neuropathies	13.3%
95	Myelitis	13.3%
96	Diabetic Amyotrophy	13.3%
97	Diabetic Autonomic Neuropathy	13.3%
98	Lafora Disease	13.3%
99	Unverricht-Lundborg Syndrome	13.3%
100	Pneumocephalus	13.3%
101	Neuralgia	13.2%
102	Neuropathic pain	13.2%
103	Sciatic Neuropathy	13.2%
104	Ulnar Neuropathies	13.2%
105	Lesion of Sciatic Nerve	13.2%
106	Ulnar Neuritis	13.2%
107	Radial nerve compression	13.2%
108	Radial Tunnel Syndrome	13.2%
109	Peroneal Neuropathies	13.2%
110	Radial Neuropathy	13.2%
111	Median Neuropathy	13.2%
112	Sciatic Nerve Palsy	13.2%
113	Femoral Neuropathy	13.2%
114	Tibial Neuropathy	13.2%
115	Ulnar Nerve Palsy	13.2%
116	Radial nerve palsy	13.2%
117	Limbic Encephalitis	13.1%
118	Cubital Tunnel Syndrome	13%
119	Leukoencephalitis, Acute Hemorrhagic	12.2%
120	Epidural Abscess	12.1%
121	Olfactory Nerve Injuries	12.1%
122	Paraneoplastic Cerebellar Degeneration	12.1%
123	Neuroleptic Malignant Syndrome	12.1%
124	Myelinolysis, Central Pontine	12.1%
125	Huntington Disease	12.1%
126	Neuromuscular Diseases	11.9%
127	MPTP Poisoning	11.9%
128	Sleep Disorders, Circadian Rhythm	11.6%
129	Subdural Effusion	11.6%
130	Parkinsonian Disorders	11.6%
131	Nocturnal Myoclonus Syndrome	11.6%
132	Encephalomyelitis, Acute Disseminated	11.5%
133	Myasthenia Gravis, Autoimmune, Experimental	11.5%
134	Hand-Arm Vibration Syndrome	11.3%
135	Central Nervous System Cysts	11.2%
136	Neuromyelitis Optica	11.1%
137	Fibromyalgia	11%
138	Medial Tibial Stress Syndrome	11%
139	Neuritis, Autoimmune, Experimental	10.9%
140	Polyradiculopathy	10.9%
141	Dyskinesia, Drug-Induced	10.9%
142	Canavan Disease	10.9%
143	Alexander Disease	10.9%
144	Mitochondrial Myopathies	10.8%
145	Eosinophilia-Myalgia Syndrome	10.7%
146	Friedreich Ataxia	10.7%
147	Central Nervous System Infection	10.7%
148	Optic Neuropathy	10.7%
149	Brain Injuries	10.7%
150	Brain Neoplasms	10.6%
151	Multiple Sclerosis	10.6%
152	Spinal Cord Neoplasms	10.6%
153	Tuberous Sclerosis	10.5%
154	neurofibroma	10.4%
155	Facial Nerve Injuries	10.4%
156	Facial Nerve Diseases	10.3%
157	Craniocerebral Trauma	10.3%
158	Parasomnia	10.3%
159	Motor Neuron Disease	10.3%
160	Dyssomnias	10.3%
161	Vestibulocochlear Nerve Diseases	10.2%
162	Decerebrate State	10.2%
163	Hemiparesis	10.2%
164	Hydranencephaly	10.2%
165	Meningism	10.2%
166	Neural Tube Defects	10.2%
167	Paresis	10.2%
168	Seizures	10.2%
169	Sensation Disorders	10.2%
170	Tethered Cord Syndrome	10.2%
171	Central Nervous System Neoplasms	10.2%
172	Complex partial seizures	10.2%
173	Iniencephaly	10.2%
174	Craniorachischisis	10.2%
175	Exencephaly	10.2%
176	Monoparesis	10.2%
177	Septo-Optic Dysplasia	10.2%
178	Cortical Dysplasia	10.2%
179	Neurogenic Inflammation	10.2%
180	Gait Disorders, Neurologic	10.2%
181	Neuromuscular Manifestations	10.2%
182	Malformations of Cortical Development	10.2%
183	Amyloid Neuropathies, Familial	10.1%
184	Sweating, Gustatory	10.1%
185	Thoracic Outlet Syndrome	10.1%
186	Auriculotemporal Syndrome	10.1%
187	Horner Syndrome	10%
188	Polymyositis	9.9%
189	Leukoencephalopathy, Progressive Multifocal	9.9%
190	Meige Syndrome	9.8%
191	Cerebral Ventriculitis	9.8%
192	Epilepsy, Post-Traumatic	9.8%
193	Akathisia, Drug-Induced	9.6%
194	Central Cord Syndrome	9.4%
195	Meningitis, Bacterial	9.3%
196	Meningitis, Fungal	9.3%
197	Chorea	9.2%
198	Frontotemporal dementia	9.2%
199	Posterior Leukoencephalopathy Syndrome	9%
200	Posterior reversible encephalopathy syndrome	9%
201	Brain Abscess	8.9%
202	Ophthalmoplegia	8.9%
203	External Ophthalmoplegia	8.9%
204	Alstrom Syndrome	8.9%
205	Akinetic Mutism	8.9%
206	Anoxic Encephalopathy	8.9%
207	Arachnoiditis	8.9%
208	Basal Ganglia Diseases	8.9%
209	Brain Damage, Chronic	8.9%
210	Cerebellar Diseases	8.9%
211	Encephalitis	8.9%
212	Encephalomalacia	8.9%
213	Epilepsy	8.9%
214	Hydrocephalus	8.9%
215	Congenital Hydrocephalus	8.9%
216	Hypothalamic Diseases	8.9%
217	Aseptic Meningitis	8.9%
218	Familial Periodic Paralysis	8.9%
219	Syringomyelia	8.9%
220	Thalamic Diseases	8.9%
221	Intracranial Hypertension	8.9%
222	Aura	8.9%
223	Leukoencephalopathy	8.9%
224	Essential Tremor	8.9%
225	Neuroaxonal Dystrophies	8.9%
226	Familial Tremor	8.9%
227	Headache Disorders	8.9%
228	Intracranial Hypotension	8.9%
229	Brain Edema	8.9%
230	Brain Hypoxia	8.9%
231	Aqueductal Stenosis	8.9%
232	Pneumorrhachis	8.9%
233	Writer's Cramp	8.9%
234	Hepatolenticular Degeneration	8.8%
235	Lupus Vasculitis, Central Nervous System	8.8%
236	Refsum Disease	8.7%
237	Cerebellar Neoplasms	8.6%
238	Vasculitis, Central Nervous System	8.6%
239	Jet Lag Syndrome	8.6%
240	Pupil Disorders	8.5%
241	Mitochondrial Encephalomyopathies	8.5%
242	Neurobehavioral Manifestations	8.5%
243	Brain Death	8.2%
244	Coma, Post-Head Injury	8.2%
245	Myoclonic Epilepsy	8.1%
246	Epilepsy, Temporal Lobe	8.1%
247	Epilepsy, Rolandic	8.1%
248	Benign Rolandic Epilepsy	8.1%
249	Uveomeningoencephalitic Syndrome	8.1%
250	Dementia, Vascular	8.1%
251	Brain Hemorrhage, Traumatic	8.1%
252	Muscular Dystrophy	8.1%
253	Sturge-Weber Syndrome	8.1%
254	Vertigo	8.1%
255	Alcohol-Induced Disorders, Nervous System	8.1%
256	Orbital Myositis	8.1%
257	Pyomyositis	7.9%
258	Creutzfeldt-Jakob disease	7.9%
259	Basal Ganglia Cerebrovascular Disease	7.9%
260	Ataxia Telangiectasia	7.9%
261	Brain Injuries, Diffuse	7.8%
262	Traumatic Brain Injury	7.8%
263	Cerebellar Ataxia	7.8%
264	Supratentorial Neoplasms	7.8%
265	Torticollis	7.8%
266	Multiple Sclerosis, Chronic Progressive	7.8%
267	Multiple Sclerosis, Relapsing-Remitting	7.8%
268	Amblyopia	7.8%
269	Vocal Cord Paralysis	7.7%
270	Cerebrospinal Fluid Otorrhea	7.7%
271	Cerebrospinal Fluid Rhinorrhea	7.7%
272	Gait Ataxia	7.6%
273	Myalgia	7.6%
274	Neuronal Ceroid-Lipofuscinoses	7.5%
275	Tuberculosis, Meningeal	7.4%
276	Carotid Artery Injuries	7.3%
277	Juvenile Myoclonic Epilepsy	7.3%
278	Myoclonic Epilepsies, Progressive	7.3%
279	Vascular Headaches	7.2%
280	Hypoxia-Ischemia, Brain	7.2%
281	Tardive Dyskinesia	7.1%
282	Persistent Vegetative State	7.1%
283	Voice Disorders	6.9%
284	Voice Disturbance	6.9%
285	Brain Diseases, Metabolic	6.8%
286	Cerebrovascular Disorders	6.8%
287	Optic Atrophy	6.8%
288	Optic Neuritis	6.8%
289	Papilledema	6.8%
290	Strabismus	6.8%
291	Tolosa-Hunt Syndrome	6.8%
292	Cerebrovascular Insufficiency	6.8%
293	Arsenic Poisoning	6.8%
294	Dementia	6.8%
295	Central Nervous System Fungal Infections	6.8%
296	Conus Medullaris Syndrome	6.8%
297	Spinal Cord Vascular Diseases	6.8%
298	Smith-Magenis syndrome	6.7%
299	Dural Arteriovenous Fistula	6.7%
300	Alice in Wonderland Syndrome	6.7%
301	Facial Injuries	6.7%
302	Facial Neuralgia	6.7%
303	Progressive bulbar palsy	6.7%
304	Sleep Talking	6.7%
305	Manganese Poisoning	6.7%
306	Sleep Disorders, Intrinsic	6.7%
307	Orthostatic intolerance	6.7%
308	Bulbar palsy	6.7%
309	Cockayne Syndrome	6.6%
310	Anosmia	6.6%
311	Ataxia	6.6%
312	Athetosis	6.6%
313	Catalepsy	6.6%
314	Dystonia	6.6%
315	Hemiplegia	6.6%
316	Locked-In Syndrome	6.6%
317	Meningeal Neoplasms	6.6%
318	Meningomyelocele	6.6%
319	Muscle Hypertonia	6.6%
320	Muscle hypotonia	6.6%
321	Myoclonus	6.6%
322	Myotonia	6.6%
323	Paraplegia	6.6%
324	Pseudobulbar Palsy	6.6%
325	Quadriplegia	6.6%
326	Spasm	6.6%
327	Spastic Paraplegia	6.6%
328	Status Epilepticus	6.6%
329	Taste Disorders	6.6%
330	Tremor	6.6%
331	Spina Bifida	6.6%
332	Monoplegia	6.6%
333	Hypokinesia	6.6%
334	Paraparesis	6.6%
335	Bradykinesia	6.6%
336	Waxy flexibility	6.6%
337	Action Tremor	6.6%
338	Resting Tremor	6.6%
339	Dysosmia	6.6%
340	Quadriparesis	6.6%
341	Mercury Poisoning, Nervous System	6.6%
342	Olfaction Disorders	6.6%
343	Myokymia	6.6%
344	Lead Poisoning, Nervous System	6.6%
345	Vestibular Neuronitis	6.6%
346	Somatosensory Disorders	6.6%
347	Hyperkinesia	6.6%
348	Intention tremor	6.6%
349	Cerebral Palsy	6.6%
350	Epilepsies, Partial	6.6%
351	Epilepsy, Generalized	6.6%
352	Leukomalacia, Periventricular	6.6%
353	Pseudotumor Cerebri	6.6%
354	POEMS Syndrome	6.6%
355	Hypertensive Encephalopathy	6.6%
356	Simple Partial Seizures	6.6%
357	Epilepsy, Reflex	6.6%
358	Postural Orthostatic Tachycardia Syndrome	6.6%
359	Headache Disorders, Primary	6.6%
360	Headache Disorders, Secondary	6.6%
361	Medication overuse headache	6.6%
362	Alcohol Withdrawal Seizures	6.6%
363	Welander Distal Myopathy	6.6%
364	Akathisia	6.6%
365	Restlessness	6.6%
366	Psychomotor Agitation	6.6%
367	Hypokalemic periodic paralysis	6.5%
368	Brain Concussion	6.5%
369	Diffuse Axonal Injury	6.5%
370	Brain Stem Neoplasms	6.5%
371	Neurofibrosarcoma	6.4%
372	Pituitary Adenoma	6.2%
373	Pituitary Neoplasms	6.2%
374	Optic Atrophy, Hereditary, Leber	6.2%
375	Optic Nerve Glioma	6.2%
376	Toxoplasmosis, Cerebral	6.2%
377	Vertebral Artery Dissection	6.1%
378	Amnesia, Transient Global	6.1%
379	Gait Apraxia	6%
380	Meningitis, Cryptococcal	6%
381	Meningitis, Listeria	6%
382	Meningitis, Haemophilus	5.9%
383	Meningitis, Pneumococcal	5.9%
384	MELAS Syndrome	5.9%
385	Basal Ganglia Hemorrhage	5.8%
386	Choroid Plexus Papilloma	5.8%
387	Reflex, Abnormal	5.7%
388	Hyporeflexia	5.7%
389	Hyperreflexia	5.7%
390	Dermatomyositis	5.6%
391	Vision Disorders	5.5%
392	Metamorphopsia	5.5%
393	Visual Impairment	5.5%
394	Pituitary Apoplexy	5.5%
395	Muscular Dystrophy, Duchenne	5.5%
396	Optic Neuropathy, Ischemic	5.5%
397	Anterior Ischemic Optic Neuropathy	5.5%
398	Central Nervous System Bacterial Infections	5.5%
399	Post-Traumatic Headache	5.5%
400	Tension Headache	5.5%
401	Epilepsy, Complex Partial	5.5%
402	Migraine Disorders	5.5%
403	Abdominal Migraine	5.5%
404	Status Migrainosus	5.5%
405	Cervicogenic Headache	5.5%
406	Brain Contusion	5.4%
407	Facial Hemiatrophy	5.4%
408	Melkersson-Rosenthal Syndrome	5.4%
409	Brain Infarction	5.4%
410	Kearns-Sayre syndrome	5.4%
411	Anisocoria	5.4%
412	Confusion	5.4%
413	Facial paralysis	5.4%
414	Lethargy	5.4%
415	Memory Disorders	5.4%
416	Muscle Cramp	5.4%
417	Perceptual Disorders	5.4%
418	Psychomotor Disorders	5.4%
419	Tonic Pupil	5.4%
420	Anhedonia	5.4%
421	Disorientation	5.4%
422	Facial Paresis	5.4%
423	Memory Loss	5.4%
424	Hemisensory Neglect	5.4%
425	Dysacusis	5.4%
426	Subarachnoid Hemorrhage, Traumatic	5.4%
427	Carotid Artery, Internal, Dissection	5.4%
428	Sleep Bruxism	5.3%
429	Subacute Sclerosing Panencephalitis	5.3%
430	Anencephaly	5.3%
431	Meningocele	5.3%
432	Muscular Atrophy	5.3%
433	Respiratory Paralysis	5.3%
434	Encephalocele	5.3%
435	Putaminal Hemorrhage	5.3%
436	Tetany	5.3%
437	Pituitary Diseases	5.2%
438	Infarction, Middle Cerebral Artery	5.2%
439	Infarction, Anterior Cerebral Artery	5.2%
440	Infarction, Posterior Cerebral Artery	5.2%
441	Classical Lissencephalies and Subcortical Band Heterotopias	5.1%
442	Carotid Artery Diseases	5%
443	Brain Ischemia	5%
444	Esotropia	5%
445	Exotropia	5%
446	Hypotension, Orthostatic	5%
447	Sleep Apnea Syndromes	5%
448	Cerebrovascular accident	5%
449	Kluver-Bucy Syndrome	5%
450	Vasospasm, Intracranial	5%
451	Spinal Cord Ischemia	5%
452	Intracranial Arterial Diseases	5%
453	Post-Exercise Hypotension	5%
454	Adrenoleukodystrophy	4.9%
455	Disorders of Excessive Somnolence	4.9%
456	Sleep Initiation and Maintenance Disorders	4.9%
457	Night Terrors	4.9%
458	Somnambulism	4.9%
459	Trigeminal Nerve Disorder	4.9%
460	Transient Insomnia	4.9%
461	Sleep Paralysis	4.9%
462	Chronic Insomnia	4.9%
463	REM Sleep Behavior Disorder	4.9%
464	Hypersomnia	4.9%
465	Auditory Perceptual Disorders	4.9%
466	Cluster Headache	4.9%
467	Migraine with Aura	4.9%
468	Familial Hemiplegic Migraine	4.9%
469	Chronic Paroxysmal Hemicrania	4.9%
470	SUNCT Syndrome	4.9%
471	Paroxysmal Hemicrania	4.9%
472	Dermal Sinus	4.9%
473	Dysgeusia	4.9%
474	Formication	4.9%
475	Hyperalgesia	4.9%
476	Hyperesthesia	4.9%
477	Hypesthesia	4.9%
478	Language Disorders	4.9%
479	Numbness	4.9%
480	Paresthesia	4.9%
481	Paraparesis, Spastic	4.9%
482	Spina Bifida Cystica	4.9%
483	Trismus	4.9%
484	Spina Bifida Occulta	4.9%
485	Epilepsia Partialis Continua	4.9%
486	Hypogeusia	4.9%
487	Meningeal Carcinomatosis	4.9%
488	Brown-Sequard Syndrome	4.9%
489	Lissencephaly	4.9%
490	Polymicrogyria	4.9%
491	Pachygyria	4.9%
492	Schizencephaly	4.9%
493	Lockjaw	4.9%
494	Allodynia	4.9%
495	Lead Poisoning, Nervous System, Childhood	4.9%
496	Lead Poisoning, Nervous System, Adult	4.9%
497	Periventricular Nodular Heterotopia	4.9%
498	Ageusia	4.9%
499	Tuberculosis, Central Nervous System	4.9%
500	Cerebral Infarction	4.8%
501	Brain Stem Infarctions	4.8%
502	Acoustic Neuroma	4.8%
503	Giant Cell Arteritis	4.7%
504	Temporal Arteritis	4.7%
505	Alexia	4.6%
506	Dyslexia	4.6%
507	Duane Retraction Syndrome	4.5%
508	Lateral Medullary Syndrome	4.5%
509	Consciousness Disorders	4.5%
510	Mental Retardation	4.5%
511	Muscle Weakness	4.5%
512	Depressed Level of Consciousness	4.5%
513	Mental deficiency	4.5%
514	Intellectual Disability	4.5%
515	Mobius Syndrome	4.5%
516	Bell Palsy	4.5%
517	Catatonia	4.5%
518	Herpes Zoster Oticus	4.5%
519	Aphonia	4.4%
520	Sleep Deprivation	4.4%
521	Dysphonia	4.4%
522	Moyamoya Disease	4.4%
523	West Nile Fever	4.3%
524	Hematoma, Subdural	4.2%
525	Hematoma, Epidural, Cranial	4.2%
526	Empty Sella Syndrome	4.2%
527	Hyperpituitarism	4.2%
528	Hypopituitarism	4.2%
529	Hypophysitis	4.2%
530	Eye Injuries	4.1%
531	Cerebral Arterial Diseases	4.1%
532	Vertebrobasilar Insufficiency	4.1%
533	Anterior Spinal Artery Syndrome	4.1%
534	Basilar Artery Stenosis	4.1%
535	Vertebral Artery Stenosis	4.1%
536	Sleep Apnea, Obstructive	4.1%
537	Sleep Apnea, Central	4.1%
538	Intracranial Hemorrhage, Hypertensive	4.1%
539	Transient Cerebral Ischemia	4.1%
540	Narcolepsy	4.1%
541	Trigeminal Neuralgia	4.1%
542	Kleine-Levin Syndrome	4.1%
543	Agraphia	4.1%
544	Anomia	4.1%
545	Cluttering	4.1%
546	Language Development Disorders	4.1%
547	Speech Disorders	4.1%
548	Syncope	4.1%
549	Stupor	4.1%
550	Dysgraphia	4.1%
551	Presyncope	4.1%
552	Dyslalia	4.1%
553	Congenital nystagmus	4%
554	Diplopia	4%
555	Muscle Rigidity	4%
556	Muscle Spasticity	4%
557	Scotoma	4%
558	Photophobia	4%
559	Cogwheel Rigidity	4%
560	Hemifacial Spasm	4%
561	Amaurosis	4%
562	Blindness	4%
563	Nuchal Rigidity	4%
564	Reye Syndrome	4%
565	Neuroaspergillosis	4%
566	Intracranial Embolism and Thrombosis	3.9%
567	Hepatic Encephalopathy	3.9%
568	Agnosia	3.9%
569	Apraxias	3.9%
570	Hallucinations	3.9%
571	Hemianopsia	3.9%
572	Hyperacusis	3.9%
573	Tinnitus	3.9%
574	Visual Agnosia	3.9%
575	Anosognosia	3.9%
576	Wernicke-Korsakoff Syndrome	3.9%
577	Phonophobia	3.9%
578	Hearing Loss	3.9%
579	Sarcopenia	3.9%
580	Hematoma, Subdural, Intracranial	3.7%
581	Hematoma, Subdural, Chronic	3.7%
582	Hematoma, Subdural, Acute	3.7%
583	Hyperprolactinemia	3.7%
584	Subclavian Steal Syndrome	3.7%
585	Pick Disease of the Brain	3.7%
586	Cataplexy	3.6%
587	Aphasia	3.6%
588	Articulation Disorders	3.6%
589	Echolalia	3.6%
590	Stuttering	3.6%
591	Dysphasia	3.6%
592	Pseudorabies	3.5%
593	Dysarthria	3.4%
594	Aicardi's syndrome	3.4%
595	Hoarseness	3.3%
596	Amnesia	3.3%
597	Delirium	3.3%
598	Dissociative Amnesia	3.3%
599	Color blindness	3.3%
600	Global Amnesia	3.3%
601	Toxoplasmosis, Congenital	3.3%
602	Cri-du-Chat Syndrome	3.3%
603	Down Syndrome	3.3%
604	Brain Diseases, Metabolic, Inborn	3.3%
605	Trisomy 21	3.3%
606	Eye Burns	3.3%
607	Malaria, Cerebral	3.3%
608	Alcohol Withdrawal Delirium	3.3%
609	Meningioma	3.3%
610	Williams Syndrome	3.3%
611	Carotid Stenosis	3.3%
612	Intracranial Aneurysm	3.3%
613	Microcephaly	3.3%
614	Macrocephaly	3.3%
615	Neurocysticercosis	3.3%
616	Amaurosis Fugax	3.3%
617	Blindness, Cortical	3.3%
618	Dyscalculia	3.3%
619	Neurosyphilis	3.3%
620	Intracranial Arteriosclerosis	3.3%
621	Cerebral Atherosclerosis	3.3%
622	Rett Syndrome	3.3%
623	Subarachnoid Hemorrhage	3.3%
624	Cerebral Arteriosclerosis	3.3%
625	Cerebral Hemorrhage	3.3%
626	Cerebral Thrombosis	3.2%
627	Intracranial Embolism	3.2%
628	Intracranial Thrombosis	3.2%
629	Porencephaly	3.2%
630	Deafness	3.2%
631	Hearing Loss, Sudden	3.2%
632	Gerstmann Syndrome	3.2%
633	Hearing Loss, Bilateral	3.2%
634	Hearing Loss, High-Frequency	3.2%
635	Hearing Loss, Mixed Conductive-Sensorineural	3.2%
636	Prosopagnosia	3.2%
637	Apraxia, Ideomotor	3.2%
638	Charles Bonnet Syndrome	3.2%
639	Hearing Loss, Unilateral	3.2%
640	Complete Hearing Loss	3.2%
641	Alien Hand Syndrome	3.2%
642	Deaf Mutism	3.2%
643	Mutism	3%
644	Selective Mutism	3%
645	Acromegaly	3%
646	Holoprosencephaly	2.9%
647	Cerebral Amyloid Angiopathy	2.9%
648	Sinus Thrombosis, Intracranial	2.9%
649	Prader-Willi Syndrome	2.8%
650	Wernicke Encephalopathy	2.8%
651	AIDS Dementia Complex	2.8%
652	Waterhouse-Friderichsen Syndrome	2.8%
653	Corneal Scar	2.8%
654	Phantom pain	2.8%
655	Phantom Limb Pain	2.8%
656	Lyme Neuroborreliosis	2.8%
657	Alexia, Pure	2.8%
658	Cavernous Sinus Thrombosis	2.7%
659	Sagittal Sinus Thrombosis	2.7%
660	Retrograde amnesia	2.7%
661	Amnesia, Anterograde	2.7%
662	Carotid Artery Thrombosis	2.7%
663	Menkes Kinky Hair Syndrome	2.7%
664	Kernicterus	2.5%
665	Corneal Perforation	2.5%
666	Fragile X Syndrome	2.3%
667	Nelson Syndrome	2.3%
668	Rubinstein-Taybi Syndrome	2.2%
669	Fabry Disease	2.1%
670	Prolactinoma	2.1%
671	Growth Hormone-Secreting Pituitary Adenoma	2.1%
672	Galactosemias	2%
673	Urea Cycle Disorders, Inborn	2%
674	Tyrosinemias	2%
675	Homocystinuria	1.8%
676	Leigh Disease	1.8%
677	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.6%
678	Mucopolysaccharidosis II	1.6%
679	Glycogen storage disease type II	1.4%
680	Zellweger Syndrome	1.4%
681	Gaucher Disease	1.2%
682	Tay-Sachs Disease	1.2%
683	Niemann-Pick Disease, Type C	1.1%

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