MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Pituitary Apoplexy

(UMLS:C0032001)

Definition:: The sudden loss of blood supply to the PITUITARY GLAND, leading to tissue NECROSIS and loss of function (PANHYPOPITUITARISM). The most common cause is hemorrhage or INFARCTION of a PITUITARY ADENOMA. It can also result from acute hemorrhage into SELLA TURCICA due to HEAD TRAUMA; INTRACRANIAL HYPERTENSION; or other acute effects of central nervous system hemorrhage. Clinical signs include severe HEADACHE; HYPOTENSION; bilateral visual disturbances; UNCONSCIOUSNESS; and COMA.
UMLS ID:: C0032001
MeSH ID:: D010899

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.300.535.625|C10.228.140.617.738.350

Classification 2:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.253.573.600

Classification 3:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.700.725

Synonym(s)

Pituitary Apoplexy

Pituitary Gland Apoplexy

Pituitary apoplexy

pituitary apoplexy

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Cabergoline	FAERS: 1		US FAERS
2	Bromocriptine		3226523 4020451 7293648	CTD
3	Chlorpromazine		718334	CTD
4	Clomiphene		8731710	CTD
5	Dexamethasone		12699433 12699434	CTD
6	Gadolinium DTPA		9401663	CTD
7	Goserelin			SIDER
8	Isosorbide Dinitrate		11958251	CTD
9	Leuprolide		View details 8706284 9413812 12507807 16832587 19842040	CTD SIDER
10	Nafarelin			SIDER
11	Octreotide			SIDER
12	Thyrotropin-Releasing Hormone			SIDER
13	Triptorelin Pamoate			SIDER
14	histrelin			SIDER
15	isosorbide-5-mononitrate		3585391	CTD
16	reviparin		9365341 11958251 15251667	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Intracranial Hemorrhage, Hypertensive	36.9%
2	Basal Ganglia Cerebrovascular Disease	35%
3	Subarachnoid Hemorrhage, Traumatic	34.8%
4	Empty Sella Syndrome	34.2%
5	Hyperpituitarism	34.2%
6	Hypopituitarism	34.2%
7	Hypophysitis	34.2%
8	Basal Ganglia Hemorrhage	32.5%
9	Vascular Headaches	31.7%
10	Subarachnoid Hemorrhage	31.6%
11	Cerebral Hemorrhage	31.6%
12	Dementia, Vascular	31.3%
13	Leukomalacia, Periventricular	30.7%
14	Carotid Artery Diseases	29.5%
15	Brain Ischemia	29.5%
16	Cerebrovascular accident	29.5%
17	Vasospasm, Intracranial	29.5%
18	Intracranial Arterial Diseases	29.5%
19	Brain Infarction	29.1%
20	Pituitary Adenoma	28.4%
21	Pituitary Neoplasms	28.4%
22	Intracranial Embolism and Thrombosis	28%
23	Vasculitis, Central Nervous System	26.6%
24	Hypoxia-Ischemia, Brain	26.5%
25	Moyamoya Disease	25.9%
26	Putaminal Hemorrhage	25.6%
27	Hyperprolactinemia	25.3%
28	Carotid Artery Injuries	25.1%
29	Meningoencephalitis	24.6%
30	Subdural Effusion	24%
31	Encephalomyelitis	23.3%
32	Infarction, Middle Cerebral Artery	23%
33	Infarction, Anterior Cerebral Artery	23%
34	Infarction, Posterior Cerebral Artery	23%
35	Akinetic Mutism	23%
36	Anoxic Encephalopathy	23%
37	Basal Ganglia Diseases	23%
38	Brain Damage, Chronic	23%
39	Cerebellar Diseases	23%
40	Encephalitis	23%
41	Encephalomalacia	23%
42	Epilepsy	23%
43	Hydrocephalus	23%
44	Congenital Hydrocephalus	23%
45	Thalamic Diseases	23%
46	Intracranial Hypertension	23%
47	Aura	23%
48	Leukoencephalopathy	23%
49	Neuroaxonal Dystrophies	23%
50	Headache Disorders	23%
51	Intracranial Hypotension	23%
52	Brain Edema	23%
53	Brain Hypoxia	23%
54	Aqueductal Stenosis	23%
55	Brain Hemorrhage, Traumatic	22.9%
56	Carotid Artery Thrombosis	22.1%
57	Acromegaly	21.8%
58	Cerebral Infarction	21.7%
59	Brain Stem Infarctions	21.7%
60	Dandy-Walker Syndrome	21.1%
61	Pneumocephalus	21%
62	Carotid Stenosis	21%
63	Intracranial Aneurysm	21%
64	Brain Abscess	20.7%
65	Multiple System Atrophy	20.7%
66	Parkinsonian Disorders	19.7%
67	Cerebral Arterial Diseases	19.5%
68	Vertebrobasilar Insufficiency	19.5%
69	Basilar Artery Stenosis	19.5%
70	Vertebral Artery Stenosis	19.5%
71	Transient Cerebral Ischemia	19.5%
72	Intracranial Arteriosclerosis	19.5%
73	Cerebral Atherosclerosis	19.5%
74	Cerebral Arteriosclerosis	19.5%
75	Brain Diseases, Metabolic	19.4%
76	Dementia	19.4%
77	Lewy Body Disease	19.4%
78	Prolactinoma	19%
79	Growth Hormone-Secreting Pituitary Adenoma	19%
80	Posterior Leukoencephalopathy Syndrome	19%
81	Posterior reversible encephalopathy syndrome	19%
82	Brain Injuries	18.9%
83	Brain Neoplasms	18.8%
84	Cerebral Thrombosis	18.8%
85	Intracranial Embolism	18.8%
86	Intracranial Thrombosis	18.8%
87	Carotid Artery, Internal, Dissection	18.4%
88	Lupus Vasculitis, Central Nervous System	18.4%
89	Epilepsy, Post-Traumatic	18.3%
90	Lateral Medullary Syndrome	18.1%
91	Meningitis	18%
92	Movement Disorders	18%
93	Pachymeningitis	18%
94	Spinal Cord Diseases	18%
95	Ocular Motility Disorders	17.8%
96	Cyclophoria	17.8%
97	Nelson Syndrome	17.7%
98	Hematoma, Subdural	17.5%
99	Hematoma, Epidural, Cranial	17.5%
100	Brain Death	17.1%
101	Vertebral Artery Dissection	17.1%
102	Spinal Cord Vascular Diseases	16.7%
103	Marchiafava-Bignami Disease	16.6%
104	Myelitis	16.5%
105	Meige Syndrome	16.3%
106	Cerebral Ventriculitis	16.3%
107	Epidural Abscess	16%
108	Huntington Disease	15.8%
109	Giant Cell Arteritis	15.7%
110	Temporal Arteritis	15.7%
111	Amblyopia	15.7%
112	Central Nervous System Infection	15.5%
113	Myoclonic Epilepsy	15.1%
114	Epilepsy, Temporal Lobe	15.1%
115	Epilepsy, Rolandic	15.1%
116	Benign Rolandic Epilepsy	15.1%
117	Parkinson Disease	15.1%
118	Cerebellar Neoplasms	14.9%
119	Subclavian Steal Syndrome	14.6%
120	Shy-Drager Syndrome	14.5%
121	Dystonia Musculorum Deformans	14.3%
122	Hematoma, Subdural, Intracranial	14.3%
123	Hematoma, Subdural, Chronic	14.3%
124	Hematoma, Subdural, Acute	14.3%
125	Neuroleptic Malignant Syndrome	14.2%
126	Myelinolysis, Central Pontine	14.2%
127	Sinus Thrombosis, Intracranial	14.2%
128	Creutzfeldt-Jakob disease	14%
129	Progressive supranuclear palsy	14%
130	Stiff-Person Syndrome	13.9%
131	Cerebral Palsy	13.7%
132	Epilepsies, Partial	13.7%
133	Epilepsy, Generalized	13.7%
134	Pseudotumor Cerebri	13.7%
135	Hypertensive Encephalopathy	13.7%
136	Simple Partial Seizures	13.7%
137	Epilepsy, Reflex	13.7%
138	Headache Disorders, Primary	13.7%
139	Headache Disorders, Secondary	13.7%
140	Medication overuse headache	13.7%
141	Leukoencephalopathy, Progressive Multifocal	13.4%
142	Amnesia, Transient Global	13.4%
143	Prion Diseases	13.3%
144	MELAS Syndrome	12.9%
145	Limbic Encephalitis	12.7%
146	Striatonigral Degeneration	12.6%
147	Cerebral Amyloid Angiopathy	12.5%
148	Subacute Combined Degeneration	12.2%
149	Presenile dementia	12.2%
150	Senile dementia	12.2%
151	Hepatolenticular Degeneration	12%
152	Cavernous Sinus Thrombosis	11.9%
153	Sagittal Sinus Thrombosis	11.9%
154	Spinal Muscular Atrophy	11.8%
155	Progressive Muscular Atrophy	11.8%
156	Spinal Cord Injuries	11.8%
157	Diabetic Angiopathies	11.7%
158	Cranial nerve diseases	11.6%
159	Demyelinating Diseases	11.6%
160	Demyelination	11.6%
161	Neuromuscular Diseases	11.6%
162	Chronobiology Disorders	11.6%
163	Hypothalamic Diseases	11.5%
164	Kluver-Bucy Syndrome	11.5%
165	Asterixis	11.4%
166	Ballismus	11.4%
167	Diabetes Insipidus	11.4%
168	Juvenile Myoclonic Epilepsy	11.3%
169	Myoclonic Epilepsies, Progressive	11.3%
170	Meningitis, Bacterial	11.3%
171	Meningitis, Fungal	11.3%
172	Myocardial Ischemia	11.2%
173	Brain Injuries, Diffuse	11.2%
174	Traumatic Brain Injury	11.2%
175	Cerebellar Ataxia	11.1%
176	Supratentorial Neoplasms	11.1%
177	Poliomyelitis	11.1%
178	Amyotrophic Lateral Sclerosis	11%
179	Leukoencephalitis, Acute Hemorrhagic	11%
180	Paraneoplastic Cerebellar Degeneration	10.7%
181	Toxoplasmosis, Cerebral	10.7%
182	Persistent Vegetative State	10.6%
183	MPTP Poisoning	10.5%
184	Ophthalmoplegic Migraine	10.4%
185	Chronic Fatigue Syndrome	10.3%
186	Motor Neuron Disease	10.1%
187	Aneurysm	10%
188	Angiomatosis	10%
189	Aortic Diseases	10%
190	Arterial Occlusive Diseases	10%
191	Hyperemia	10%
192	Hypotension	10%
193	Superior Vena Cava Syndrome	10%
194	Telangiectasis	10%
195	Vasculitis	10%
196	Venous Insufficiency	10%
197	Peripheral Vascular Diseases	10%
198	Embolism and Thrombosis	10%
199	Angiodysplasia	10%
200	Capillary Leak Syndrome	10%
201	Trauma, Nervous System	10%
202	Prehypertension	10%
203	Thoracic Outlet Syndrome	9.9%
204	Miller Fisher Syndrome	9.9%
205	Aortic Aneurysm	9.9%
206	Aortitis	9.9%
207	Leriche Syndrome	9.9%
208	Periphlebitis	9.9%
209	Phlebitis	9.9%
210	Thromboangiitis Obliterans	9.9%
211	Arachnoiditis	9.9%
212	Aseptic Meningitis	9.9%
213	Syringomyelia	9.9%
214	Essential Tremor	9.9%
215	Familial Tremor	9.9%
216	Pneumorrhachis	9.9%
217	Writer's Cramp	9.9%
218	Reye Syndrome	9.9%
219	Spinal Cord Ischemia	9.8%
220	Encephalomyelitis, Acute Disseminated	9.8%
221	Hepatic Encephalopathy	9.8%
222	Hand-Arm Vibration Syndrome	9.8%
223	Nervous System Neoplasms	9.8%
224	Neurologic Manifestations	9.8%
225	Neurotoxicity Syndromes	9.8%
226	Cerebrovascular Disorders	9.7%
227	Cerebrovascular Insufficiency	9.7%
228	Optic Neuropathy, Ischemic	9.6%
229	Anterior Ischemic Optic Neuropathy	9.6%
230	Friedreich Ataxia	9.4%
231	Spinal Cord Neoplasms	9.4%
232	Canavan Disease	9.3%
233	Alexander Disease	9.3%
234	Restless Legs Syndrome	9.3%
235	Retinal Vein Occlusion	9.3%
236	Lafora Disease	9.2%
237	Unverricht-Lundborg Syndrome	9.2%
238	Post-Traumatic Headache	9.1%
239	Tension Headache	9.1%
240	Epilepsy, Complex Partial	9.1%
241	Migraine Disorders	9.1%
242	Abdominal Migraine	9.1%
243	Status Migrainosus	9.1%
244	Cervicogenic Headache	9.1%
245	Ataxia Telangiectasia	9.1%
246	Myelitis, Transverse	9%
247	Fabry Disease	8.9%
248	Akathisia, Drug-Induced	8.9%
249	Myocardial Reperfusion Injury	8.8%
250	Polyradiculoneuropathy	8.8%
251	Polyradiculoneuritis	8.8%
252	Mitochondrial Encephalomyopathies	8.7%
253	Brain Diseases, Metabolic, Inborn	8.6%
254	Vascular System Injuries	8.6%
255	Sturge-Weber Syndrome	8.5%
256	Sleep Wake Disorders	8.5%
257	Gigantism	8.5%
258	Malignant Atrophic Papulosis	8.5%
259	Shwartzman Phenomenon	8.5%
260	Opsoclonus-Myoclonus Syndrome	8.4%
261	Compartment syndromes	8.4%
262	Hepatic Veno-Occlusive Disease	8.4%
263	Peliosis Hepatis	8.4%
264	Varicocele	8.4%
265	Reperfusion Injury	8.3%
266	Splenic Infarction	8.3%
267	Vascular Neoplasms	8.3%
268	Central Nervous System Fungal Infections	8.3%
269	Conus Medullaris Syndrome	8.3%
270	Vasoplegia	8.3%
271	Adrenoleukodystrophy	8.3%
272	Hemorrhoids	8.3%
273	Adrenal Gland Diseases	8.2%
274	Gonadal Disorders	8.2%
275	Parathyroid Diseases	8.2%
276	Thyroid Diseases	8.2%
277	Postphlebitic Syndrome	8.2%
278	Coronary Aneurysm	7.9%
279	Auditory Perceptual Disorders	7.8%
280	Autonomic Dysreflexia	7.8%
281	Complex Regional Pain Syndromes	7.8%
282	Diabetic Foot	7.7%
283	Adrenal Gland Neoplasms	7.7%
284	Dyskinesia, Drug-Induced	7.7%
285	Thrombophlebitis	7.7%
286	Wernicke Encephalopathy	7.6%
287	AIDS Dementia Complex	7.6%
288	Tuberculosis, Meningeal	7.5%
289	Aortic Rupture	7.4%
290	Diffuse Axonal Injury	7.4%
291	Brain Stem Neoplasms	7.4%
292	Central Nervous System Bacterial Infections	7.2%
293	Mesenteric vascular insufficiency	7.2%
294	Arteriovenous fistula	7.2%
295	Angioedema	7.1%
296	Colitis, Ischemic	7.1%
297	Kernicterus	7%
298	Blue Toe Syndrome	6.9%
299	Bone Diseases, Endocrine	6.9%
300	Endocrine Gland Neoplasms	6.9%
301	Frontotemporal dementia	6.9%
302	Cluster Headache	6.8%
303	Migraine with Aura	6.8%
304	Familial Hemiplegic Migraine	6.8%
305	Chronic Paroxysmal Hemicrania	6.8%
306	SUNCT Syndrome	6.8%
307	Paroxysmal Hemicrania	6.8%
308	Diabetes Mellitus	6.8%
309	Peripheral Nerve Injuries	6.7%
310	Subacute Sclerosing Panencephalitis	6.7%
311	Parathyroid Neoplasms	6.7%
312	Thyroid Neoplasm	6.7%
313	Thyroid carcinoma	6.7%
314	Myasthenia Gravis	6.7%
315	Diabetic Retinopathy	6.6%
316	Scrapie	6.6%
317	Central Cord Syndrome	6.6%
318	Coronary heart disease	6.6%
319	Myocardial Infarction	6.6%
320	Acute Coronary Syndrome	6.6%
321	Hypotension, Orthostatic	6.6%
322	Post-Exercise Hypotension	6.6%
323	Chorea	6.5%
324	Aortic Aneurysm, Abdominal	6.5%
325	Aortic Aneurysm, Thoracic	6.5%
326	Coronary Thrombosis	6.5%
327	Coronary Artery Disease	6.5%
328	Anterior Spinal Artery Syndrome	6.5%
329	Brain Contusion	6.5%
330	Lambert-Eaton Myasthenic Syndrome	6.3%
331	Guillain-Barre Syndrome	6.2%
332	Heart Diseases	6.2%
333	Brain Concussion	6.2%
334	Meningitis, Cryptococcal	6.1%
335	Meningitis, Listeria	6.1%
336	Meningitis, Haemophilus	6.1%
337	Meningitis, Pneumococcal	6.1%
338	Scimitar Syndrome	6.1%
339	Diabetic Neuropathies	6%
340	Diabetic Amyotrophy	6%
341	Diabetic Autonomic Neuropathy	6%
342	Dysautonomia	6%
343	Vagus Nerve Disorder	6%
344	Glossopharyngeal Neuralgia	6%
345	Abducens Nerve Diseases	6%
346	Heavy Metal Poisoning, Nervous System	6%
347	Neuromuscular Junction Diseases	6%
348	Tauopathies	6%
349	Trochlear Nerve Diseases	6%
350	Peripheral Nervous System Diseases	6%
351	Sleep Disorders, Circadian Rhythm	6%
352	Pituitary Diseases	5.9%
353	Aneurysm, Dissecting	5.9%
354	Arteriosclerosis	5.9%
355	Arteritis	5.9%
356	Embolism	5.9%
357	Erythromelalgia	5.9%
358	Fibromuscular Dysplasia	5.9%
359	Malignant Hypertension	5.9%
360	Raynaud Disease	5.9%
361	Thromboembolism	5.9%
362	Thrombosis	5.9%
363	Essential Hypertension	5.9%
364	Aneurysm, Ruptured	5.9%
365	Iliac Aneurysm	5.9%
366	Pulmonary artery stenosis	5.9%
367	White Coat Hypertension	5.9%
368	Systemic Vasculitis	5.9%
369	Embolus	5.9%
370	Dwarfism	5.9%
371	Botulism	5.8%
372	Central Nervous System Cysts	5.8%
373	Pituitary Apoplexy	5.7%
374	Kounis Syndrome	5.7%
375	Pick Disease of the Brain	5.7%
376	May-Thurner Syndrome	5.6%
377	Angina Pectoris	5.6%
378	Polyarteritis Nodosa	5.6%
379	Takayasu Arteritis	5.6%
380	Torticollis	5.6%
381	Choroid Plexus Papilloma	5.5%
382	Progressive bulbar palsy	5.5%
383	Bulbar palsy	5.5%
384	Adrenocortical carcinoma	5.4%
385	Alice in Wonderland Syndrome	5.3%
386	Adrenal Cortex Diseases	5.3%
387	Euthyroid Sick Syndromes	5.3%
388	Goiter	5.3%
389	Hyperparathyroidism	5.3%
390	Hyperthyroidism	5.3%
391	Hyperthyroxinemia	5.3%
392	Hypogonadism	5.3%
393	Hypoparathyroidism	5.3%
394	Hypothyroidism	5.3%
395	Delayed Puberty	5.3%
396	Precocious Puberty	5.3%
397	Thyroiditis	5.3%
398	Hypogonadotropic hypogonadism	5.3%
399	Testotoxicosis	5.3%
400	Secondary hypothyroidism	5.3%
401	Primary Hyperthyroidism	5.3%
402	Primary Hypothyroidism	5.3%
403	Olfactory Nerve Injuries	5.3%
404	Embolism, Amniotic Fluid	5.2%
405	Refsum Disease	5.2%
406	Myopathy	5.2%
407	Pregnancy Complications, Cardiovascular	5.2%
408	Cardiovascular Abnormalities	5.2%
409	Optic Neuropathy	5.2%
410	Neuromyelitis Optica	5.2%
411	Congenital Hypothyroidism	5.2%
412	Causalgia	5.1%
413	ovarian neoplasm	5.1%
414	Facial Nerve Diseases	5.1%
415	Craniocerebral Trauma	5.1%
416	Parasomnia	5.1%
417	Dyssomnias	5.1%
418	Vestibulocochlear Nerve Diseases	5%
419	Decerebrate State	5%
420	Graves Disease	5%
421	Hemiparesis	5%
422	Hydranencephaly	5%
423	Meningism	5%
424	Neural Tube Defects	5%
425	Paresis	5%
426	Retinal Artery Occlusion	5%
427	Seizures	5%
428	Sensation Disorders	5%
429	Tethered Cord Syndrome	5%
430	Central Nervous System Neoplasms	5%
431	Complex partial seizures	5%
432	Retinal Vasculitis	5%
433	Hypertensive Retinopathy	5%
434	Iniencephaly	5%
435	Craniorachischisis	5%
436	Exencephaly	5%
437	Monoparesis	5%
438	Septo-Optic Dysplasia	5%
439	Cortical Dysplasia	5%
440	Neurogenic Inflammation	5%
441	Gait Disorders, Neurologic	5%
442	Neuromuscular Manifestations	5%
443	Malformations of Cortical Development	5%
444	Dural Arteriovenous Fistula	5%
445	Sweating, Gustatory	5%
446	Auriculotemporal Syndrome	5%
447	Horner Syndrome	4.9%
448	Anterior Compartment Syndrome	4.9%
449	Vasculitis, Leukocytoclastic, Cutaneous	4.9%
450	Gastric Antral Vascular Ectasia	4.9%
451	Diabetic Cardiomyopathies	4.9%
452	Abdominal Compartment Syndrome	4.9%
453	Thyroid Nodule	4.9%
454	Varicose Ulcer	4.9%
455	Primary Graft Dysfunction	4.9%
456	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	4.9%
457	CREST Syndrome	4.9%
458	Tuberculosis, Central Nervous System	4.9%
459	West Nile Fever	4.8%
460	Facial Nerve Injuries	4.7%
461	Multiple Sclerosis	4.7%
462	Testicular Neoplasms	4.7%
463	Galactosemias	4.5%
464	Urea Cycle Disorders, Inborn	4.5%
465	Tyrosinemias	4.5%
466	Testicular Diseases	4.5%
467	Ovarian Diseases	4.4%
468	Pupil Disorders	4.4%
469	Jet Lag Syndrome	4.4%
470	Neurobehavioral Manifestations	4.4%
471	Tuberous Sclerosis	4.4%
472	Reflex Sympathetic Dystrophy	4.4%
473	Nocturnal Myoclonus Syndrome	4.4%
474	Coronary Occlusion	4.3%
475	Microvascular Angina	4.3%
476	Coronary Stenosis	4.3%
477	ST segment elevation myocardial infarction	4.3%
478	Paraneoplastic Encephalomyelitis	4.3%
479	Mesenteric Vascular Occlusion	4.3%
480	Mucocutaneous Lymph Node Syndrome	4.3%
481	Uveomeningoencephalitic Syndrome	4.3%
482	Vertigo	4.3%
483	Alcohol-Induced Disorders, Nervous System	4.3%
484	Myasthenia Gravis, Autoimmune, Experimental	4.2%
485	Livedo Reticularis	4.2%
486	Renal hypertension	4.2%
487	Renal Artery Obstruction	4.2%
488	Renal Artery Stenosis	4.2%
489	Neuroaspergillosis	4.2%
490	Hemangioma, Cavernous	4.2%
491	Scurvy	4.2%
492	Lemierre Syndrome	4.2%
493	Tardive Dyskinesia	4.2%
494	Ophthalmoplegia	4.1%
495	External Ophthalmoplegia	4.1%
496	Homocystinuria	4.1%
497	Leigh Disease	4.1%
498	Waterhouse-Friderichsen Syndrome	4.1%
499	Cushing Syndrome	3.9%
500	Hyperaldosteronism	3.9%
501	Hyperparathyroidism, Secondary	3.9%
502	Hypoaldosteronism	3.9%
503	Thyrotoxicosis	3.9%
504	Hyperparathyroidism, Primary	3.9%
505	Thyroid Hormone Resistance Syndrome	3.9%
506	Arteriosclerosis Obliterans	3.9%
507	Atherosclerosis	3.9%
508	Air Embolism	3.9%
509	Endarteritis	3.9%
510	Venous Thrombosis	3.9%
511	Deep Vein Thrombosis	3.9%
512	Venous Thromboembolism	3.9%
513	Pseudorabies	3.8%
514	Gestational Diabetes	3.8%
515	Latent Autoimmune Diabetes in Adults	3.8%
516	Voice Disorders	3.8%
517	Voice Disturbance	3.8%
518	Diabetes Mellitus, Experimental	3.8%
519	Smith-Magenis syndrome	3.7%
520	Shock, Cardiogenic	3.7%
521	Acrodynia	3.7%
522	Ischemic contracture	3.7%
523	Vocal Cord Paralysis	3.7%
524	Angina, Unstable	3.7%
525	Angioedemas, Hereditary	3.7%
526	Menkes Kinky Hair Syndrome	3.7%
527	Tricuspid Atresia	3.7%
528	Arrhythmogenic Right Ventricular Dysplasia	3.7%
529	Cryoglobulinemia	3.7%
530	Neurosyphilis	3.7%
531	Charcot-Marie-Tooth Disease	3.6%
532	Kallmann Syndrome	3.6%
533	granulosa cell tumor	3.6%
534	Carcinoma, Ovarian Epithelial	3.6%
535	Bacterial Endocarditis	3.4%
536	Hermaphroditism	3.4%
537	Disorders of Sex Development	3.4%
538	Addison Disease	3.3%
539	Cardiac Tamponade	3.3%
540	Endocarditis	3.3%
541	Cardiac Arrest	3.3%
542	Heart failure	3.3%
543	Pericardial effusion	3.3%
544	Pericarditis	3.3%
545	Pneumopericardium	3.3%
546	Cor pulmonale	3.3%
547	Ventricular Outflow Obstruction	3.3%
548	Ventricular Dysfunction	3.3%
549	Cardiomyopathies	3.3%
550	Autoimmune thyroiditis	3.3%
551	Pleuropericarditis	3.3%
552	Primary Adrenal Insufficiency	3.3%
553	Intermittent Claudication	3.3%
554	Pulmonary Embolism	3.3%
555	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	3.3%
556	Aortic Valve Stenosis	3.3%
557	Cardiomyopathy, Dilated	3.3%
558	Myxedema	3.3%
559	Orchitis	3.3%
560	Pulmonary Valve Stenosis	3.3%
561	Reflex, Abnormal	3.3%
562	Hyporeflexia	3.3%
563	Hyperreflexia	3.3%
564	Myotonia Congenita	3.3%
565	Neuritis	3.3%
566	Polyneuritis	3.3%
567	Radiculitis	3.3%
568	Polyneuropathy	3.3%
569	Mononeuritis	3.3%
570	Mononeuropathies	3.3%
571	Brachial Plexus Neuropathies	3.3%
572	Radiculopathy	3.3%
573	Mononeuropathy Multiplex	3.3%
574	Nerve Root Compression	3.3%
575	No-Reflow Phenomenon	3.3%
576	Zellweger Syndrome	3.3%
577	Alcohol Withdrawal Seizures	3.3%
578	Ovarian Hyperstimulation Syndrome	3.3%
579	Hyperglycemic Hyperosmolar Nonketotic Coma	3.3%
580	Hashimoto Disease	3.3%
581	Cerebrospinal Fluid Otorrhea	3.3%
582	Cerebrospinal Fluid Rhinorrhea	3.3%
583	Neuritis, Autoimmune, Experimental	3.3%
584	Purpura, Hyperglobulinemic	3.3%
585	Brachial Plexus Neuritis	3.3%
586	Neuralgic Amyotrophy	3.3%
587	Gait Ataxia	3.3%
588	Lyme Neuroborreliosis	3.2%
589	Coronary Restenosis	3.2%
590	Klinefelter Syndrome	3.2%
591	Carbamoyl-Phosphate Synthase I Deficiency Disease	3.1%
592	Turner Syndrome	3%
593	Coma, Post-Head Injury	3%
594	Multiple Endocrine Neoplasia	3%
595	Pancreatic Neoplasm	3%
596	Myotonic Dystrophy	3%
597	Behcet Syndrome	3%
598	Waldenstrom Macroglobulinemia	3%
599	Multiple Myeloma	3%
600	Akathisia	2.9%
601	Restlessness	2.9%
602	Psychomotor Agitation	2.9%
603	Corpus Luteum Cyst	2.8%
604	Ovarian Cysts	2.8%
605	Heart Block	2.8%
606	Tachycardia	2.8%
607	Tachyarrhythmia	2.8%
608	Toxoplasmosis, Congenital	2.8%
609	Aortic coarctation	2.8%
610	Cor Triatriatum	2.8%
611	Coronary Vessel Anomalies	2.8%
612	Diabetic Nephropathy	2.8%
613	Patent ductus arteriosus	2.8%
614	Ebstein Anomaly	2.8%
615	Heart Septal Defects	2.8%
616	Tetralogy of Fallot	2.8%
617	Transposition of Great Vessels	2.8%
618	Hypoplastic Left Heart Syndrome	2.8%
619	Malaria, Cerebral	2.8%
620	Cardiac Output, High	2.8%
621	Myocardial Stunning	2.8%
622	Low Cardiac Output Syndrome	2.8%
623	Glycogen storage disease type II	2.8%
624	Anovulation	2.8%
625	Diabetic Ketoacidosis	2.8%
626	Oophoritis	2.8%
627	Neurocysticercosis	2.8%
628	Hypertension, Renovascular	2.8%
629	Multiple Sclerosis, Chronic Progressive	2.8%
630	Multiple Sclerosis, Relapsing-Remitting	2.8%
631	Cardiomegaly	2.8%
632	Myositis	2.8%
633	Optic Atrophy	2.8%
634	Optic Neuritis	2.8%
635	Papilledema	2.8%
636	Postpericardiotomy Syndrome	2.8%
637	Strabismus	2.8%
638	Tolosa-Hunt Syndrome	2.8%
639	Isaacs syndrome	2.8%
640	Arsenic Poisoning	2.8%
641	Myotonic Disorders	2.8%
642	Myasthenic Syndromes, Congenital	2.8%
643	Cardiac Hypertrophy	2.8%
644	Leydig Cell Tumor	2.8%
645	Hereditary Angioedema Type III	2.8%
646	Hereditary Angioedema Types I and II	2.8%
647	Angina Pectoris, Variant	2.8%
648	Rheumatic Heart Disease	2.8%
649	Facial Injuries	2.7%
650	Facial Neuralgia	2.7%
651	Sleep Talking	2.7%
652	Manganese Poisoning	2.7%
653	Sleep Disorders, Intrinsic	2.7%
654	Orthostatic intolerance	2.7%
655	Anosmia	2.7%
656	Ataxia	2.7%
657	Athetosis	2.7%
658	Catalepsy	2.7%
659	Dystonia	2.7%
660	Hemiplegia	2.7%
661	Locked-In Syndrome	2.7%
662	Meningeal Neoplasms	2.7%
663	Meningomyelocele	2.7%
664	Muscle Hypertonia	2.7%
665	Muscle hypotonia	2.7%
666	Myoclonus	2.7%
667	Myotonia	2.7%
668	Neuralgia	2.7%
669	Paraplegia	2.7%
670	Pseudobulbar Palsy	2.7%
671	Quadriplegia	2.7%
672	Spasm	2.7%
673	Spastic Paraplegia	2.7%
674	Status Epilepticus	2.7%
675	Taste Disorders	2.7%
676	Tremor	2.7%
677	Spina Bifida	2.7%
678	Monoplegia	2.7%
679	Hypokinesia	2.7%
680	Paraparesis	2.7%
681	Bradykinesia	2.7%
682	Waxy flexibility	2.7%
683	Action Tremor	2.7%
684	Resting Tremor	2.7%
685	Dysosmia	2.7%
686	Quadriparesis	2.7%
687	Mercury Poisoning, Nervous System	2.7%
688	Olfaction Disorders	2.7%
689	Myokymia	2.7%
690	Lead Poisoning, Nervous System	2.7%
691	Vestibular Neuronitis	2.7%
692	Somatosensory Disorders	2.7%
693	Neuropathic pain	2.7%
694	Hyperkinesia	2.7%
695	Intention tremor	2.7%
696	Pseudoxanthoma Elasticum	2.7%
697	Tarsal Tunnel Syndrome	2.7%
698	Cauda Equina Syndrome	2.7%
699	Hyperandrogenism	2.7%
700	Optic Nerve Glioma	2.5%
701	Gait Apraxia	2.5%
702	Alstrom Syndrome	2.5%
703	Acoustic Neuroma	2.5%
704	Cryptorchidism	2.5%
705	Hepatic Vein Thrombosis	2.5%
706	Budd-Chiari Syndrome	2.5%
707	Dextrocardia	2.5%
708	Long QT Syndrome	2.5%
709	Gonadal Dysgenesis	2.5%
710	Adrenogenital Syndrome	2.5%
711	Ovotesticular Disorders of Sex Development	2.5%
712	Hypertrophic Cardiomyopathy	2.5%
713	Pulmonary Infarction	2.5%
714	Hypertrophic obstructive cardiomyopathy	2.5%
715	Vision Disorders	2.4%
716	Metamorphopsia	2.4%
717	Visual Impairment	2.4%
718	Fibromyalgia	2.4%
719	Medial Tibial Stress Syndrome	2.4%
720	Facial Hemiatrophy	2.4%
721	Melkersson-Rosenthal Syndrome	2.4%
722	Mitochondrial Myopathies	2.4%
723	Anisocoria	2.4%
724	Confusion	2.4%
725	Facial paralysis	2.4%
726	Lethargy	2.4%
727	Memory Disorders	2.4%
728	Muscle Cramp	2.4%
729	Perceptual Disorders	2.4%
730	Psychomotor Disorders	2.4%
731	Tonic Pupil	2.4%
732	Eosinophilia-Myalgia Syndrome	2.4%
733	Anhedonia	2.4%
734	Disorientation	2.4%
735	Facial Paresis	2.4%
736	Memory Loss	2.4%
737	Hemisensory Neglect	2.4%
738	Dysacusis	2.4%
739	Amyloid Neuropathies, Familial	2.4%
740	Sleep Bruxism	2.4%
741	Anencephaly	2.3%
742	Meningocele	2.3%
743	Muscular Atrophy	2.3%
744	Respiratory Paralysis	2.3%
745	Encephalocele	2.3%
746	Tetany	2.3%
747	Carpal Tunnel Syndrome	2.3%
748	Polycystic Ovary Syndrome	2.3%
749	neurofibroma	2.3%
750	Sciatica	2.3%
751	Multiple Endocrine Neoplasia Type 1	2.2%
752	Rheumatoid Vasculitis	2.2%
753	Supravalvular aortic stenosis	2.2%
754	Lown-Ganong-Levine Syndrome	2.2%
755	Sick Sinus Syndrome	2.2%
756	Gaucher Disease	2.1%
757	Granulomatosis with polyangiitis	2.1%
758	Duane Retraction Syndrome	2.1%
759	Consciousness Disorders	2.1%
760	Mental Retardation	2.1%
761	Muscle Weakness	2.1%
762	Depressed Level of Consciousness	2.1%
763	Mental deficiency	2.1%
764	Intellectual Disability	2.1%
765	Mobius Syndrome	2.1%
766	Bell Palsy	2.1%
767	Kearns-Sayre syndrome	2.1%
768	Catatonia	2.1%
769	Herpes Zoster Oticus	2.1%
770	Familial Periodic Paralysis	2.1%
771	Aphonia	2.1%
772	Sleep Deprivation	2.1%
773	Dysphonia	2.1%
774	Carcinoid Heart Disease	2%
775	Noonan Syndrome	2%
776	Aortic Valve Insufficiency	2%
777	Restrictive cardiomyopathy	2%
778	Endocardial Fibroelastosis	2%
779	Heart Rupture, Post-Infarction	2%
780	Mitral Valve Insufficiency	2%
781	Mitral Valve Stenosis	2%
782	Myocarditis	2%
783	Pericarditis, Constrictive	2%
784	Pulmonary Valve Insufficiency	2%
785	Tricuspid Valve Insufficiency	2%
786	Tricuspid Valve Stenosis	2%
787	Ventricular Dysfunction, Left	2%
788	Right Ventricular Dysfunction	2%
789	Endomyocardial Fibrosis	2%
790	Carditis	2%
791	Heart Failure, Systolic	2%
792	Heart Failure, Diastolic	2%
793	Sciatic Neuropathy	2%
794	Ulnar Neuropathies	2%
795	Lesion of Sciatic Nerve	2%
796	Ulnar Neuritis	2%
797	Radial nerve compression	2%
798	Radial Tunnel Syndrome	2%
799	Peroneal Neuropathies	2%
800	Radial Neuropathy	2%
801	Median Neuropathy	2%
802	Sciatic Nerve Palsy	2%
803	Femoral Neuropathy	2%
804	Tibial Neuropathy	2%
805	Ulnar Nerve Palsy	2%
806	Postural Orthostatic Tachycardia Syndrome	2%
807	Radial nerve palsy	2%
808	Adams-Stokes Syndrome	1.9%
809	Atrioventricular Block	1.9%
810	Bundle-Branch Block	1.9%
811	Atrial Premature Complexes	1.9%
812	Sinoatrial Block	1.9%
813	Tachycardia, Paroxysmal	1.9%
814	Supraventricular tachycardia	1.9%
815	Tachycardia, Ventricular	1.9%
816	Wolff-Parkinson-White Syndrome	1.9%
817	Tachycardia, Reciprocating	1.9%
818	Aortopulmonary Septal Defect	1.9%
819	Double Outlet Right Ventricle	1.9%
820	Endocardial Cushion Defects	1.9%
821	Myocardial bridging	1.9%
822	Aorticopulmonary Septal Defect	1.9%
823	Cubital Tunnel Syndrome	1.9%
824	Williams Syndrome	1.8%
825	Myalgia	1.8%
826	Marfan Syndrome	1.8%
827	Subacute Bacterial Endocarditis	1.8%
828	Tay-Sachs Disease	1.8%
829	Neuronal Ceroid-Lipofuscinoses	1.8%
830	Classical Lissencephalies and Subcortical Band Heterotopias	1.8%
831	Niemann-Pick Disease, Type C	1.8%
832	Carcinoma, Pancreatic Ductal	1.8%
833	Aicardi's syndrome	1.7%
834	Hoarseness	1.7%
835	Cockayne Syndrome	1.7%
836	Sinus Arrhythmia	1.6%
837	Atrial Fibrillation	1.6%
838	Atrial Flutter	1.6%
839	Edema, Cardiac	1.6%
840	Ventricular Fibrillation	1.6%
841	Ventricular Flutter	1.6%
842	Parasystole	1.6%
843	Paroxysmal atrial fibrillation	1.6%
844	Bradycardia	1.6%
845	Alcohol Withdrawal Delirium	1.6%
846	Cardiomyopathy, Alcoholic	1.6%
847	Ectopia Cordis	1.6%
848	Esotropia	1.6%
849	Exotropia	1.6%
850	Sleep Apnea Syndromes	1.6%
851	Sudden Cardiac Death	1.6%
852	Polymyositis	1.6%
853	Left Ventricular Hypertrophy	1.6%
854	Right Ventricular Hypertrophy	1.6%
855	Single umbilical artery	1.6%
856	Chagas Cardiomyopathy	1.6%
857	Disorders of Excessive Somnolence	1.6%
858	Sleep Initiation and Maintenance Disorders	1.6%
859	Night Terrors	1.6%
860	Somnambulism	1.6%
861	Trigeminal Nerve Disorder	1.6%
862	Transient Insomnia	1.6%
863	Sleep Paralysis	1.6%
864	Chronic Insomnia	1.6%
865	REM Sleep Behavior Disorder	1.6%
866	Hypersomnia	1.6%
867	Dermal Sinus	1.6%
868	Dysgeusia	1.6%
869	Formication	1.6%
870	Hyperalgesia	1.6%
871	Hyperesthesia	1.6%
872	Hypesthesia	1.6%
873	Language Disorders	1.6%
874	Numbness	1.6%
875	Paresthesia	1.6%
876	Paraparesis, Spastic	1.6%
877	Spina Bifida Cystica	1.6%
878	Trismus	1.6%
879	Spina Bifida Occulta	1.6%
880	Epilepsia Partialis Continua	1.6%
881	Hypogeusia	1.6%
882	Meningeal Carcinomatosis	1.6%
883	Brown-Sequard Syndrome	1.6%
884	Lissencephaly	1.6%
885	Polymicrogyria	1.6%
886	Pachygyria	1.6%
887	Schizencephaly	1.6%
888	Lockjaw	1.6%
889	Allodynia	1.6%
890	Lead Poisoning, Nervous System, Childhood	1.6%
891	Lead Poisoning, Nervous System, Adult	1.6%
892	Periventricular Nodular Heterotopia	1.6%
893	Ageusia	1.6%
894	Romano-Ward Syndrome	1.6%
895	insulinoma	1.6%
896	Gastrinoma	1.6%
897	Glucagonoma	1.6%
898	Carcinoma, Endometrioid	1.6%
899	Holoprosencephaly	1.5%
900	Optic Atrophy, Hereditary, Leber	1.5%
901	Renal Osteodystrophy	1.5%
902	Renal rickets	1.5%
903	Vipoma	1.5%
904	Eye Injuries	1.4%
905	Alexia	1.4%
906	Dyslexia	1.4%
907	Muscular Dystrophy	1.4%
908	Congenital nystagmus	1.4%
909	Orbital Myositis	1.4%
910	Diplopia	1.4%
911	Muscle Rigidity	1.4%
912	Muscle Spasticity	1.4%
913	Scotoma	1.4%
914	Photophobia	1.4%
915	Cogwheel Rigidity	1.4%
916	Hemifacial Spasm	1.4%
917	Amaurosis	1.4%
918	Blindness	1.4%
919	Nuchal Rigidity	1.4%
920	Dyspnea, Paroxysmal	1.4%
921	Pyomyositis	1.4%
922	Agnosia	1.4%
923	Apraxias	1.4%
924	Hallucinations	1.4%
925	Hemianopsia	1.4%
926	Hyperacusis	1.4%
927	Tinnitus	1.4%
928	Visual Agnosia	1.4%
929	Anosognosia	1.4%
930	Wernicke-Korsakoff Syndrome	1.4%
931	Phonophobia	1.4%
932	Hearing Loss	1.4%
933	Sarcopenia	1.4%
934	Tachycardia, Atrioventricular Nodal Reentry	1.4%
935	Tachycardia, Ectopic Atrial	1.4%
936	Tachycardia, Ectopic Junctional	1.4%
937	Sinus Tachycardia	1.4%
938	Torsades de Pointes	1.4%
939	Accelerated Idioventricular Rhythm	1.4%
940	Truncus Arteriosus, Persistent	1.4%
941	Aortic Valve Prolapse	1.3%
942	Tricuspid Valve Prolapse	1.3%
943	Takotsubo Cardiomyopathy	1.3%
944	Polyradiculopathy	1.3%
945	Neurofibrosarcoma	1.3%
946	Amnesia	1.2%
947	Delirium	1.2%
948	Dissociative Amnesia	1.2%
949	Color blindness	1.2%
950	Global Amnesia	1.2%
951	Cri-du-Chat Syndrome	1.2%
952	Down Syndrome	1.2%
953	Trisomy 21	1.2%
954	POEMS Syndrome	1.2%
955	Meningioma	1.2%
956	Microcephaly	1.2%
957	Macrocephaly	1.2%
958	Hypokalemic periodic paralysis	1.2%
959	Porencephaly	1.2%
960	Prader-Willi Syndrome	1.1%
961	Sinus Arrest, Cardiac	1.1%
962	Sleep Apnea, Obstructive	1.1%
963	Sleep Apnea, Central	1.1%
964	Phantom pain	1.1%
965	Phantom Limb Pain	1.1%
966	Narcolepsy	1.1%
967	Trigeminal Neuralgia	1.1%
968	Kleine-Levin Syndrome	1.1%
969	Agraphia	1.1%
970	Anomia	1.1%
971	Cluttering	1.1%
972	Language Development Disorders	1.1%
973	Speech Disorders	1.1%
974	Syncope	1.1%
975	Stupor	1.1%
976	Dysgraphia	1.1%
977	Presyncope	1.1%
978	Dyslalia	1.1%
979	Denys-Drash Syndrome	1%
980	Eye Burns	0.9%
981	Welander Distal Myopathy	0.9%
982	Amaurosis Fugax	0.9%
983	Blindness, Cortical	0.9%
984	Dyscalculia	0.9%
985	Rett Syndrome	0.9%
986	Deafness	0.9%
987	Hearing Loss, Sudden	0.9%
988	Gerstmann Syndrome	0.9%
989	Hearing Loss, Bilateral	0.9%
990	Hearing Loss, High-Frequency	0.9%
991	Hearing Loss, Mixed Conductive-Sensorineural	0.9%
992	Prosopagnosia	0.9%
993	Apraxia, Ideomotor	0.9%
994	Charles Bonnet Syndrome	0.9%
995	Hearing Loss, Unilateral	0.9%
996	Complete Hearing Loss	0.9%
997	Alien Hand Syndrome	0.9%
998	Deaf Mutism	0.9%
999	Rubinstein-Taybi Syndrome	0.9%
1000	Dermatomyositis	0.8%
1001	Kartagener Syndrome	0.8%
1002	Corneal Scar	0.8%
1003	Muscular Dystrophy, Duchenne	0.8%
1004	Retrograde amnesia	0.8%
1005	Amnesia, Anterograde	0.8%
1006	Cataplexy	0.8%
1007	Aphasia	0.8%
1008	Articulation Disorders	0.8%
1009	Echolalia	0.8%
1010	Stuttering	0.8%
1011	Dysphasia	0.8%
1012	Fragile X Syndrome	0.7%
1013	Mutism	0.7%
1014	Selective Mutism	0.7%
1015	Dysarthria	0.7%
1016	Corneal Perforation	0.6%
1017	Alexia, Pure	0.6%
1018	Mucopolysaccharidosis II	0.5%

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