MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Creutzfeldt-Jakob disease

(UMLS:C0022336)

Definition:: A rare transmissible encephalopathy most prevalent between the ages of 50 and 70 years. Affected individuals may present with sleep disturbances, personality changes, ATAXIA; APHASIA, visual loss, weakness, muscle atrophy, MYOCLONUS, progressive dementia, and death within one year of disease onset. A familial form exhibiting autosomal dominant inheritance and a new variant CJD (potentially associated with ENCEPHALOPATHY, BOVINE SPONGIFORM) have been described. Pathological features include prominent cerebellar and cerebral cortical spongiform degeneration and the presence of PRIONS. (From N Engl J Med, 1998 Dec 31;339(27))
UMLS ID:: C0022336
MeSH ID:: D007562

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.380.165|C10.228.228.800.230

Classification 2:

Name:

Mental Disorders
MeSH Tree Number(s):: F03.615.400.300

Synonym(s)

Creutzfeldt-Jakob disease

CJD

CJD - Creutzfeldt-Jakob disease

CREUTZFELDT-JAKOB DISEASE

Classic Creutzfeldt-Jakob Disease

Creutzfeldt Jakob Syndrome

Creutzfeldt-Jacob Disease

Creutzfeldt-Jakob

Creutzfeldt-Jakob Disease

10.

Creutzfeldt-Jakob disease, unspecified

11.

Creutzfeldt-Jakob pseudosclerosis

12.

JAKOB-CREUTZFELDT DISEASE

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Carbamazepine	FAERS: 3	US FAERS
2	Clozapine	FAERS: 2	US FAERS
3	Duloxetine Hydrochloride	FAERS: 2	US FAERS
4	Gefitinib	FAERS: 2	OFFSIDES US FAERS
5	Leflunomide	FAERS: 2	OFFSIDES US FAERS
6	Lenalidomide	FAERS: 2	OFFSIDES US FAERS
7	Levetiracetam	FAERS: 2	US FAERS
8	Lithium Carbonate	FAERS: 2	OFFSIDES US FAERS
9	Lithium	FAERS: 2	US FAERS
10	Venlafaxine Hydrochloride	FAERS: 2	US FAERS
11	oxybutynin	FAERS: 2	US FAERS
12	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1	US FAERS
13	Anastrozole	FAERS: 1	US FAERS
14	Celecoxib	FAERS: 1	US FAERS
15	Clomiphene	FAERS: 1	US FAERS
16	Dasatinib	FAERS: 1	US FAERS
17	Erlotinib Hydrochloride	FAERS: 1	US FAERS
18	Fingolimod Hydrochloride	FAERS: 1	US FAERS
19	Gabapentin	FAERS: 1 Canada Vigilance: 1	Canada Vigilance US FAERS
20	Glatiramer Acetate	FAERS: 1	US FAERS
21	Imatinib Mesylate	FAERS: 1	US FAERS
22	Meclizine	FAERS: 1	US FAERS
23	Mefloquine	FAERS: 1	OFFSIDES US FAERS
24	Pregabalin	FAERS: 1	US FAERS
25	Rosuvastatin Calcium	FAERS: 1	US FAERS
26	dorzolamide	FAERS: 1	US FAERS
27	ledipasvir, sofosbuvir drug combination	FAERS: 1	US FAERS
28	montelukast	FAERS: 1	US FAERS
29	pirfenidone	FAERS: 1	US FAERS
30	rofecoxib	FAERS: 1	US FAERS
31	Acebutolol		OFFSIDES
32	Chloroquine		OFFSIDES
33	Oxaprozin		OFFSIDES
34	Prednisone acetate		OFFSIDES
35	Progesterone		OFFSIDES
36	Pyrazinamide		OFFSIDES
37	Pyridoxal Phosphate		OFFSIDES
38	Pyridoxine		OFFSIDES
39	Tiagabine		OFFSIDES
40	Vardenafil Dihydrochloride		OFFSIDES
41	acetaminophen, dextropropoxyphene, drug combination		OFFSIDES
42	efavirenz		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Kluver-Bucy Syndrome	41.8%
2	Lewy Body Disease	41.5%
3	Meningoencephalitis	41.1%
4	Encephalomyelitis	40%
5	Presenile dementia	38.3%
6	Senile dementia	38.3%
7	Dementia, Vascular	37.6%
8	Huntington Disease	36.3%
9	Subdural Effusion	32.7%
10	Epidural Abscess	31.8%
11	Myelitis	31.6%
12	Brain Abscess	28.4%
13	AIDS Dementia Complex	26.1%
14	Cerebral Ventriculitis	26%
15	Pick Disease of the Brain	25.8%
16	Multiple System Atrophy	25.6%
17	Pneumocephalus	25.4%
18	Meningitis	25%
19	Movement Disorders	25%
20	Pachymeningitis	25%
21	Spinal Cord Diseases	25%
22	Parkinsonian Disorders	24.8%
23	Akinetic Mutism	24.6%
24	Anoxic Encephalopathy	24.6%
25	Basal Ganglia Diseases	24.6%
26	Brain Damage, Chronic	24.6%
27	Cerebellar Diseases	24.6%
28	Encephalitis	24.6%
29	Encephalomalacia	24.6%
30	Epilepsy	24.6%
31	Hydrocephalus	24.6%
32	Congenital Hydrocephalus	24.6%
33	Hypothalamic Diseases	24.6%
34	Thalamic Diseases	24.6%
35	Intracranial Hypertension	24.6%
36	Aura	24.6%
37	Leukoencephalopathy	24.6%
38	Neuroaxonal Dystrophies	24.6%
39	Headache Disorders	24.6%
40	Intracranial Hypotension	24.6%
41	Brain Edema	24.6%
42	Brain Hypoxia	24.6%
43	Aqueductal Stenosis	24.6%
44	Frontotemporal dementia	24%
45	Dandy-Walker Syndrome	23.6%
46	Ocular Motility Disorders	23.3%
47	Cyclophoria	23.3%
48	Scrapie	23.2%
49	Posterior Leukoencephalopathy Syndrome	22.7%
50	Posterior reversible encephalopathy syndrome	22.7%
51	Basal Ganglia Cerebrovascular Disease	21.7%
52	Meige Syndrome	20.8%
53	Meningitis, Bacterial	20.8%
54	Meningitis, Fungal	20.8%
55	Epilepsy, Post-Traumatic	20.4%
56	Parkinson Disease	20.3%
57	Leukoencephalopathy, Progressive Multifocal	20%
58	Brain Diseases, Metabolic	20%
59	Cerebrovascular Disorders	20%
60	Cerebrovascular Insufficiency	20%
61	Central Nervous System Fungal Infections	20%
62	Marchiafava-Bignami Disease	19.9%
63	Brain Injuries	19.8%
64	Poliomyelitis	19.7%
65	Brain Neoplasms	19.7%
66	Myoclonic Epilepsy	19.4%
67	Epilepsy, Temporal Lobe	19.4%
68	Epilepsy, Rolandic	19.4%
69	Benign Rolandic Epilepsy	19.4%
70	Lupus Vasculitis, Central Nervous System	19.2%
71	Vascular Headaches	19%
72	Hypoxia-Ischemia, Brain	18.9%
73	Limbic Encephalitis	18.8%
74	Leukomalacia, Periventricular	18.7%
75	Amnesia, Transient Global	18.3%
76	Stiff-Person Syndrome	18.3%
77	Toxoplasmosis, Cerebral	17.9%
78	Dystonia Musculorum Deformans	17.8%
79	Brain Death	17.7%
80	Cerebellar Neoplasms	17.5%
81	Striatonigral Degeneration	17.2%
82	Progressive supranuclear palsy	17%
83	Tuberculosis, Meningeal	16.9%
84	Central Nervous System Bacterial Infections	16.9%
85	Neuroleptic Malignant Syndrome	16.6%
86	Myelinolysis, Central Pontine	16.6%
87	Spinal Muscular Atrophy	16.5%
88	Progressive Muscular Atrophy	16.5%
89	Sleep Wake Disorders	16.5%
90	Cerebral Palsy	16.3%
91	Epilepsies, Partial	16.3%
92	Epilepsy, Generalized	16.3%
93	Pseudotumor Cerebri	16.3%
94	Hypertensive Encephalopathy	16.3%
95	Simple Partial Seizures	16.3%
96	Epilepsy, Reflex	16.3%
97	Headache Disorders, Primary	16.3%
98	Headache Disorders, Secondary	16.3%
99	Medication overuse headache	16.3%
100	Spinal Cord Injuries	16.1%
101	Juvenile Myoclonic Epilepsy	16.1%
102	Myoclonic Epilepsies, Progressive	16.1%
103	Amblyopia	16%
104	Subacute Combined Degeneration	15.8%
105	Asterixis	15.6%
106	Ballismus	15.6%
107	Cranial nerve diseases	15.5%
108	Demyelinating Diseases	15.5%
109	Demyelination	15.5%
110	Neuromuscular Diseases	15.5%
111	Chronobiology Disorders	15.5%
112	Basal Ganglia Hemorrhage	15.1%
113	Shy-Drager Syndrome	15.1%
114	Cognition Disorders	15%
115	Myelitis, Transverse	14.9%
116	Amyotrophic Lateral Sclerosis	14.8%
117	MPTP Poisoning	14.8%
118	Arachnoiditis	14.8%
119	Aseptic Meningitis	14.8%
120	Syringomyelia	14.8%
121	Essential Tremor	14.8%
122	Familial Tremor	14.8%
123	Pneumorrhachis	14.8%
124	Writer's Cramp	14.8%
125	Restless Legs Syndrome	14.7%
126	Pituitary Apoplexy	14%
127	Leukoencephalitis, Acute Hemorrhagic	14%
128	Subacute Sclerosing Panencephalitis	14%
129	Chronic Fatigue Syndrome	13.9%
130	Brain Infarction	13.8%
131	Hepatolenticular Degeneration	13.8%
132	Pituitary Diseases	13.6%
133	Motor Neuron Disease	13.5%
134	Pituitary Adenoma	13.4%
135	Pituitary Neoplasms	13.4%
136	Ophthalmoplegic Migraine	13.4%
137	Lafora Disease	13.2%
138	Unverricht-Lundborg Syndrome	13.2%
139	Spinal Cord Neoplasms	13.1%
140	Carotid Artery Diseases	13.1%
141	Brain Ischemia	13.1%
142	Cerebrovascular accident	13.1%
143	Vasospasm, Intracranial	13.1%
144	Intracranial Arterial Diseases	13.1%
145	Brain Hemorrhage, Traumatic	13.1%
146	Auditory Perceptual Disorders	13%
147	Carotid Artery Injuries	13%
148	Brain Injuries, Diffuse	13%
149	Traumatic Brain Injury	13%
150	Cerebellar Ataxia	12.9%
151	Supratentorial Neoplasms	12.9%
152	Tuberculosis, Central Nervous System	12.9%
153	Trauma, Nervous System	12.9%
154	Putaminal Hemorrhage	12.8%
155	Prion Diseases	12.7%
156	Encephalomyelitis, Acute Disseminated	12.6%
157	Friedreich Ataxia	12.6%
158	Meningitis, Cryptococcal	12.5%
159	Brain Diseases	12.5%
160	Nervous System Neoplasms	12.5%
161	Neurologic Manifestations	12.5%
162	Neurotoxicity Syndromes	12.5%
163	Meningitis, Listeria	12.5%
164	Vasculitis, Central Nervous System	12.4%
165	Meningitis, Haemophilus	12.4%
166	Meningitis, Pneumococcal	12.4%
167	Infarction, Middle Cerebral Artery	12.4%
168	Infarction, Anterior Cerebral Artery	12.4%
169	Infarction, Posterior Cerebral Artery	12.4%
170	Persistent Vegetative State	12.3%
171	Paraneoplastic Cerebellar Degeneration	12.1%
172	Post-Traumatic Headache	12.1%
173	Tension Headache	12.1%
174	Epilepsy, Complex Partial	12.1%
175	Migraine Disorders	12.1%
176	Abdominal Migraine	12.1%
177	Status Migrainosus	12.1%
178	Cervicogenic Headache	12.1%
179	Miller Fisher Syndrome	12%
180	Conus Medullaris Syndrome	12%
181	Spinal Cord Vascular Diseases	12%
182	Akathisia, Drug-Induced	11.7%
183	Canavan Disease	11.6%
184	Alexander Disease	11.6%
185	Consciousness Disorders	11.5%
186	Polyradiculoneuropathy	11.5%
187	Depressed Level of Consciousness	11.5%
188	Polyradiculoneuritis	11.5%
189	Cerebral Infarction	11.4%
190	Brain Stem Infarctions	11.4%
191	Opsoclonus-Myoclonus Syndrome	11.3%
192	Neurotic Disorders	11.1%
193	Moyamoya Disease	11.1%
194	Reye Syndrome	10.9%
195	Neuroaspergillosis	10.9%
196	Intracranial Embolism and Thrombosis	10.9%
197	Hepatic Encephalopathy	10.9%
198	Parasomnia	10.8%
199	Dyssomnias	10.8%
200	West Nile Fever	10.7%
201	Autonomic Dysreflexia	10.7%
202	Complex Regional Pain Syndromes	10.7%
203	Central Nervous System Infection	10.4%
204	Dyskinesia, Drug-Induced	10.4%
205	Amnesia	10.4%
206	Delirium	10.4%
207	Dissociative Amnesia	10.4%
208	Global Amnesia	10.4%
209	Lateral Medullary Syndrome	10.3%
210	Cluster Headache	10.1%
211	Migraine with Aura	10.1%
212	Familial Hemiplegic Migraine	10.1%
213	Chronic Paroxysmal Hemicrania	10.1%
214	SUNCT Syndrome	10.1%
215	Paroxysmal Hemicrania	10.1%
216	Central Cord Syndrome	9.9%
217	Empty Sella Syndrome	9.9%
218	Hyperpituitarism	9.9%
219	Hypopituitarism	9.9%
220	Hypophysitis	9.9%
221	Sleep Disorders, Circadian Rhythm	9.8%
222	Wernicke Encephalopathy	9.8%
223	Mitochondrial Encephalomyopathies	9.8%
224	Chorea	9.8%
225	Pseudorabies	9.8%
226	Cerebral Arterial Diseases	9.7%
227	Vertebrobasilar Insufficiency	9.7%
228	Basilar Artery Stenosis	9.7%
229	Vertebral Artery Stenosis	9.7%
230	Intracranial Hemorrhage, Hypertensive	9.7%
231	Transient Cerebral Ischemia	9.7%
232	Diffuse Axonal Injury	9.7%
233	Brain Stem Neoplasms	9.6%
234	Brain Diseases, Metabolic, Inborn	9.4%
235	Subarachnoid Hemorrhage, Traumatic	9.3%
236	Carotid Artery, Internal, Dissection	9.3%
237	Neurosyphilis	9.3%
238	Peripheral Nerve Injuries	9%
239	Myasthenia Gravis	8.9%
240	MELAS Syndrome	8.8%
241	Adrenoleukodystrophy	8.7%
242	Torticollis	8.6%
243	Anxiety Disorders	8.6%
244	Avoidant Personality Disorder	8.6%
245	Dissociative disorder	8.6%
246	Frigidity	8.6%
247	Hypoactive Sexual Desire Disorder	8.6%
248	Disruptive, Impulse Control, and Conduct Disorders	8.6%
249	Intermittent Explosive Disorder	8.6%
250	Kleptomania	8.6%
251	Narcissistic Personality Disorder	8.6%
252	Personality Disorders	8.6%
253	Sexual Aversion Disorder	8.6%
254	Somatoform Disorder	8.6%
255	Dissociation	8.6%
256	Motor Disorders	8.6%
257	Mood Disorders	8.6%
258	Schizophrenia Spectrum and Other Psychotic Disorders	8.6%
259	Neurodevelopmental Disorders	8.6%
260	Feeding and Eating Disorders	8.6%
261	Guillain-Barre Syndrome	8.6%
262	Vertebral Artery Dissection	8.6%
263	Ataxia Telangiectasia	8.3%
264	Dysautonomia	8.3%
265	Vagus Nerve Disorder	8.3%
266	Glossopharyngeal Neuralgia	8.3%
267	Abducens Nerve Diseases	8.3%
268	Heavy Metal Poisoning, Nervous System	8.3%
269	Neuromuscular Junction Diseases	8.3%
270	Tauopathies	8.3%
271	Trochlear Nerve Diseases	8.3%
272	Peripheral Nervous System Diseases	8.3%
273	Brain Contusion	8.3%
274	Toxoplasmosis, Congenital	8.2%
275	Malaria, Cerebral	8.2%
276	Carotid Stenosis	8.1%
277	Intracranial Aneurysm	8.1%
278	Hyperprolactinemia	8.1%
279	Lambert-Eaton Myasthenic Syndrome	8.1%
280	Separation Anxiety Disorder	8.1%
281	Neurocysticercosis	8.1%
282	Intracranial Arteriosclerosis	8.1%
283	Cerebral Atherosclerosis	8.1%
284	Subarachnoid Hemorrhage	8.1%
285	Cerebral Arteriosclerosis	8.1%
286	Cerebral Hemorrhage	8.1%
287	Lyme Neuroborreliosis	8.1%
288	Cerebral Thrombosis	8.1%
289	Intracranial Embolism	8.1%
290	Intracranial Thrombosis	8.1%
291	Subclavian Steal Syndrome	8.1%
292	Choroid Plexus Papilloma	8%
293	Brain Concussion	7.9%
294	Progressive bulbar palsy	7.9%
295	Bulbar palsy	7.9%
296	Spinal Cord Ischemia	7.8%
297	Alexia, Pure	7.7%
298	Causalgia	7.6%
299	Botulism	7.6%
300	Central Nervous System Cysts	7.6%
301	Olfactory Nerve Injuries	7.5%
302	Kernicterus	7.4%
303	Alice in Wonderland Syndrome	7.4%
304	Drug abuse	7.1%
305	Substance Dependence	7.1%
306	Substance-Related Disorders	7.1%
307	Drug Dependence	7.1%
308	Neuromyelitis Optica	7.1%
309	Jet Lag Syndrome	7%
310	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	7%
311	Tardive Dyskinesia	7%
312	Myopathy	6.9%
313	Optic Neuropathy	6.9%
314	Retrograde amnesia	6.9%
315	Amnesia, Anterograde	6.9%
316	Carotid Artery Thrombosis	6.9%
317	Giant Cell Arteritis	6.8%
318	Temporal Arteritis	6.8%
319	Acromegaly	6.8%
320	Facial Nerve Diseases	6.8%
321	Craniocerebral Trauma	6.8%
322	Cerebral Amyloid Angiopathy	6.7%
323	Sinus Thrombosis, Intracranial	6.7%
324	Vestibulocochlear Nerve Diseases	6.7%
325	Decerebrate State	6.7%
326	Hemiparesis	6.7%
327	Hydranencephaly	6.7%
328	Meningism	6.7%
329	Neural Tube Defects	6.7%
330	Paresis	6.7%
331	Seizures	6.7%
332	Sensation Disorders	6.7%
333	Tethered Cord Syndrome	6.7%
334	Central Nervous System Neoplasms	6.7%
335	Complex partial seizures	6.7%
336	Iniencephaly	6.7%
337	Craniorachischisis	6.7%
338	Exencephaly	6.7%
339	Monoparesis	6.7%
340	Septo-Optic Dysplasia	6.7%
341	Cortical Dysplasia	6.7%
342	Neurogenic Inflammation	6.7%
343	Gait Disorders, Neurologic	6.7%
344	Neuromuscular Manifestations	6.7%
345	Malformations of Cortical Development	6.7%
346	Sweating, Gustatory	6.6%
347	Auriculotemporal Syndrome	6.6%
348	Horner Syndrome	6.6%
349	Sleep Talking	6.6%
350	Sleep Disorders, Intrinsic	6.6%
351	Multiple Sclerosis	6.6%
352	Facial Nerve Injuries	6.6%
353	Reflex Sympathetic Dystrophy	6.5%
354	Nocturnal Myoclonus Syndrome	6.5%
355	Creutzfeldt-Jakob disease	6.5%
356	Refsum Disease	6.5%
357	Cavernous Sinus Thrombosis	6%
358	Sagittal Sinus Thrombosis	6%
359	Dementia	6%
360	Hematoma, Subdural	5.9%
361	Hematoma, Epidural, Cranial	5.9%
362	Anterior Spinal Artery Syndrome	5.8%
363	Myasthenia Gravis, Autoimmune, Experimental	5.8%
364	Waterhouse-Friderichsen Syndrome	5.8%
365	Pupil Disorders	5.7%
366	Neurobehavioral Manifestations	5.7%
367	Mental Retardation	5.7%
368	Mental deficiency	5.7%
369	Intellectual Disability	5.7%
370	Ophthalmoplegia	5.7%
371	External Ophthalmoplegia	5.7%
372	Paraneoplastic Encephalomyelitis	5.6%
373	Tuberous Sclerosis	5.6%
374	Fabry Disease	5.6%
375	Uveomeningoencephalitic Syndrome	5.6%
376	Sturge-Weber Syndrome	5.5%
377	Vertigo	5.5%
378	Alcohol-Induced Disorders, Nervous System	5.5%
379	Sleep Bruxism	5.5%
380	Acrodynia	5.4%
381	Galactosemias	5.4%
382	Urea Cycle Disorders, Inborn	5.4%
383	Tyrosinemias	5.4%
384	Charcot-Marie-Tooth Disease	5.3%
385	Brachial Plexus Neuritis	5.2%
386	Neuralgic Amyotrophy	5.2%
387	Nelson Syndrome	5.2%
388	Alcohol Withdrawal Delirium	5.1%
389	Prolactinoma	5.1%
390	Growth Hormone-Secreting Pituitary Adenoma	5.1%
391	Hematoma, Subdural, Intracranial	5.1%
392	Hematoma, Subdural, Chronic	5.1%
393	Hematoma, Subdural, Acute	5.1%
394	Vocal Cord Paralysis	5%
395	Adjustment Disorders	5%
396	Affective Disorders, Psychotic	5%
397	Agoraphobia	5%
398	Anorexia Nervosa	5%
399	Antisocial Personality Disorder	5%
400	Bipolar Disorder	5%
401	Body Dysmorphic Disorders	5%
402	Borderline Personality Disorder	5%
403	Capgras Syndrome	5%
404	Child Behavior Disorders	5%
405	Developmental Disabilities	5%
406	Child Development Disorders, Pervasive	5%
407	Claustrophobia	5%
408	Conversion disorder	5%
409	Cyclothymic Disorder	5%
410	Dependent Personality Disorder	5%
411	Depressive disorder	5%
412	Developmental Coordination Disorder	5%
413	Exhibitionism	5%
414	Factitious Disorders	5%
415	Firesetting Behavior	5%
416	Head Banging	5%
417	Histrionic Personality Disorder	5%
418	Hypochondriasis	5%
419	Masochism	5%
420	Melancholia	5%
421	Motor Skills Disorders	5%
422	Dissociative Identity Disorder	5%
423	Neurasthenia	5%
424	Obsessive-Compulsive Disorder	5%
425	Oppositional Defiant Disorder	5%
426	Panic Disorder	5%
427	Paranoid Personality Disorder	5%
428	Pedophilia	5%
429	Pseudodementia	5%
430	Psychotic Disorders	5%
431	Sadism	5%
432	Schizoaffective Disorder	5%
433	Schizoid Personality Disorder	5%
434	Schizophrenia	5%
435	Schizophrenia, Childhood	5%
436	Schizotypal Personality Disorder	5%
437	Stereotypic Movement Disorder	5%
438	Transvestism	5%
439	Trichotillomania	5%
440	Voyeurism	5%
441	Attention Deficit and Disruptive Behavior Disorders	5%
442	Hyperkinetic Heart Syndrome	5%
443	Reactive Attachment Disorder	5%
444	Sexual and Gender Disorders	5%
445	Gender Dysphoria	5%
446	Paranoia	5%
447	Compulsive Personality Disorder	5%
448	Bulimia Nervosa	5%
449	Neuritis	4.9%
450	Polyneuritis	4.9%
451	Radiculitis	4.9%
452	Polyneuropathy	4.9%
453	Mononeuritis	4.9%
454	Mononeuropathies	4.9%
455	Brachial Plexus Neuropathies	4.9%
456	Radiculopathy	4.9%
457	Mononeuropathy Multiplex	4.9%
458	Nerve Root Compression	4.9%
459	Homocystinuria	4.9%
460	Psychoses, Substance-Induced	4.9%
461	Voice Disorders	4.9%
462	Voice Disturbance	4.9%
463	Leigh Disease	4.8%
464	Smith-Magenis syndrome	4.8%
465	Dural Arteriovenous Fistula	4.7%
466	Myotonia Congenita	4.7%
467	Sleep Deprivation	4.7%
468	Cerebrospinal Fluid Otorrhea	4.7%
469	Cerebrospinal Fluid Rhinorrhea	4.7%
470	Neuritis, Autoimmune, Experimental	4.7%
471	Gait Ataxia	4.6%
472	Mutism	4.6%
473	Selective Mutism	4.6%
474	Coma, Post-Head Injury	4.6%
475	Disorders of Excessive Somnolence	4.5%
476	Sleep Initiation and Maintenance Disorders	4.5%
477	Night Terrors	4.5%
478	Somnambulism	4.5%
479	Transient Insomnia	4.5%
480	Sleep Paralysis	4.5%
481	Chronic Insomnia	4.5%
482	REM Sleep Behavior Disorder	4.5%
483	Hypersomnia	4.5%
484	Tarsal Tunnel Syndrome	4.5%
485	Cauda Equina Syndrome	4.5%
486	Menkes Kinky Hair Syndrome	4.5%
487	Alcohol Withdrawal Seizures	4.4%
488	Multiple Sclerosis, Chronic Progressive	4.3%
489	Multiple Sclerosis, Relapsing-Remitting	4.3%
490	Myotonic Dystrophy	4.3%
491	Reflex, Abnormal	4.1%
492	Hyporeflexia	4.1%
493	Hyperreflexia	4.1%
494	Akathisia	4.1%
495	Restlessness	4.1%
496	Psychomotor Agitation	4.1%
497	Marijuana Abuse	4.1%
498	Opioid-Related Disorders	4.1%
499	Nicotine Dependence	4.1%
500	Opioid abuse	4.1%
501	Phencyclidine Abuse	4.1%
502	Substance Abuse, Intravenous	4.1%
503	Substance Withdrawal Syndrome	4.1%
504	Tobacco Use Disorder	4.1%
505	Alcohol-Related Disorders	4.1%
506	Amphetamine-Related Disorders	4.1%
507	Cocaine-Related Disorders	4.1%
508	Alexia	4%
509	Dyslexia	4%
510	Carbamoyl-Phosphate Synthase I Deficiency Disease	4%
511	Gambling	4%
512	Myositis	4%
513	Optic Atrophy	4%
514	Optic Neuritis	4%
515	Papilledema	4%
516	Premature Ejaculation	4%
517	Strabismus	4%
518	Tolosa-Hunt Syndrome	4%
519	Isaacs syndrome	4%
520	Erectile dysfunction	4%
521	Arsenic Poisoning	4%
522	Myotonic Disorders	4%
523	Myasthenic Syndromes, Congenital	4%
524	Diabetic Neuropathies	3.9%
525	Facial Injuries	3.9%
526	Facial Neuralgia	3.9%
527	Diabetic Amyotrophy	3.9%
528	Diabetic Autonomic Neuropathy	3.9%
529	Manganese Poisoning	3.9%
530	Orthostatic intolerance	3.9%
531	Anosmia	3.9%
532	Ataxia	3.9%
533	Athetosis	3.9%
534	Catalepsy	3.9%
535	Dystonia	3.9%
536	Hemiplegia	3.9%
537	Locked-In Syndrome	3.9%
538	Meningeal Neoplasms	3.9%
539	Meningomyelocele	3.9%
540	Muscle Hypertonia	3.9%
541	Muscle hypotonia	3.9%
542	Myoclonus	3.9%
543	Myotonia	3.9%
544	Neuralgia	3.9%
545	Paraplegia	3.9%
546	Pseudobulbar Palsy	3.9%
547	Quadriplegia	3.9%
548	Spasm	3.9%
549	Spastic Paraplegia	3.9%
550	Status Epilepticus	3.9%
551	Taste Disorders	3.9%
552	Tremor	3.9%
553	Spina Bifida	3.9%
554	Monoplegia	3.9%
555	Hypokinesia	3.9%
556	Paraparesis	3.9%
557	Bradykinesia	3.9%
558	Waxy flexibility	3.9%
559	Action Tremor	3.9%
560	Resting Tremor	3.9%
561	Dysosmia	3.9%
562	Quadriparesis	3.9%
563	Mercury Poisoning, Nervous System	3.9%
564	Olfaction Disorders	3.9%
565	Myokymia	3.9%
566	Lead Poisoning, Nervous System	3.9%
567	Vestibular Neuronitis	3.9%
568	Somatosensory Disorders	3.9%
569	Neuropathic pain	3.9%
570	Hyperkinesia	3.9%
571	Intention tremor	3.9%
572	Carpal Tunnel Syndrome	3.8%
573	Dyscalculia	3.8%
574	neurofibroma	3.8%
575	Zellweger Syndrome	3.8%
576	Sciatica	3.8%
577	Optic Nerve Glioma	3.7%
578	Gait Apraxia	3.6%
579	Glycogen storage disease type II	3.6%
580	Narcolepsy	3.5%
581	Kleine-Levin Syndrome	3.5%
582	Alstrom Syndrome	3.5%
583	Hand-Arm Vibration Syndrome	3.4%
584	Neonatal Abstinence Syndrome	3.4%
585	Vision Disorders	3.4%
586	Metamorphopsia	3.4%
587	Visual Impairment	3.4%
588	Fibromyalgia	3.4%
589	Optic Neuropathy, Ischemic	3.4%
590	Anterior Ischemic Optic Neuropathy	3.4%
591	Medial Tibial Stress Syndrome	3.4%
592	Facial Hemiatrophy	3.3%
593	Melkersson-Rosenthal Syndrome	3.3%
594	Mitochondrial Myopathies	3.3%
595	Anisocoria	3.3%
596	Confusion	3.3%
597	Facial paralysis	3.3%
598	Lethargy	3.3%
599	Memory Disorders	3.3%
600	Muscle Cramp	3.3%
601	Perceptual Disorders	3.3%
602	Psychomotor Disorders	3.3%
603	Tonic Pupil	3.3%
604	Eosinophilia-Myalgia Syndrome	3.3%
605	Anhedonia	3.3%
606	Disorientation	3.3%
607	Facial Paresis	3.3%
608	Memory Loss	3.3%
609	Hemisensory Neglect	3.3%
610	Dyspareunia	3.3%
611	Dysacusis	3.3%
612	Anencephaly	3.3%
613	Combat Disorders	3.3%
614	Dysthymic Disorder	3.3%
615	Hysteria	3.3%
616	Meningocele	3.3%
617	Muscular Atrophy	3.3%
618	Respiratory Paralysis	3.3%
619	Schizophrenia, Catatonic	3.3%
620	Schizophrenia, Disorganized	3.3%
621	Post-Traumatic Stress Disorder	3.3%
622	Attention Deficit Disorder	3.3%
623	Seasonal Affective Disorder	3.3%
624	Conduct Disorder	3.3%
625	Social Communication Disorder	3.3%
626	Psychological Trauma	3.3%
627	Hoarding Disorder	3.3%
628	Phonological Disorder	3.3%
629	Encephalocele	3.3%
630	Psychoses, Alcoholic	3.3%
631	Tetany	3.3%
632	Acoustic Neuroma	3.3%
633	Sciatic Neuropathy	3.3%
634	Ulnar Neuropathies	3.3%
635	Lesion of Sciatic Nerve	3.3%
636	Ulnar Neuritis	3.3%
637	Radial nerve compression	3.3%
638	Radial Tunnel Syndrome	3.3%
639	Peroneal Neuropathies	3.3%
640	Radial Neuropathy	3.3%
641	Median Neuropathy	3.3%
642	Sciatic Nerve Palsy	3.3%
643	Femoral Neuropathy	3.3%
644	Tibial Neuropathy	3.3%
645	Ulnar Nerve Palsy	3.3%
646	Postural Orthostatic Tachycardia Syndrome	3.3%
647	Radial nerve palsy	3.3%
648	Amyloid Neuropathies, Familial	3.2%
649	Cubital Tunnel Syndrome	3.2%
650	Cataplexy	3.1%
651	Gaucher Disease	3%
652	Duane Retraction Syndrome	2.9%
653	Muscle Weakness	2.9%
654	Mobius Syndrome	2.9%
655	Bell Palsy	2.9%
656	Catatonia	2.8%
657	Enuresis	2.8%
658	Herpes Zoster Oticus	2.8%
659	Familial Periodic Paralysis	2.8%
660	Aphonia	2.8%
661	Dysphonia	2.8%
662	Classical Lissencephalies and Subcortical Band Heterotopias	2.8%
663	Tay-Sachs Disease	2.7%
664	Thoracic Outlet Syndrome	2.6%
665	Alcohol Use Disorder	2.6%
666	Alcoholic Intoxication	2.6%
667	Heroin Dependence	2.6%
668	Morphine Dependence	2.6%
669	Alcohol abuse	2.6%
670	Depression, Postpartum	2.6%
671	Esotropia	2.6%
672	Exotropia	2.6%
673	Hypotension, Orthostatic	2.6%
674	Sleep Apnea Syndromes	2.6%
675	Polymyositis	2.6%
676	Premenstrual Dysphoric Disorder	2.6%
677	Post-Exercise Hypotension	2.6%
678	Trigeminal Nerve Disorder	2.6%
679	Niemann-Pick Disease, Type C	2.6%
680	Dermal Sinus	2.6%
681	Dysgeusia	2.6%
682	Formication	2.6%
683	Hyperalgesia	2.6%
684	Hyperesthesia	2.6%
685	Hypesthesia	2.6%
686	Language Disorders	2.6%
687	Numbness	2.6%
688	Paresthesia	2.6%
689	Paraparesis, Spastic	2.6%
690	Spina Bifida Cystica	2.6%
691	Trismus	2.6%
692	Spina Bifida Occulta	2.6%
693	Epilepsia Partialis Continua	2.6%
694	Hypogeusia	2.6%
695	Meningeal Carcinomatosis	2.6%
696	Brown-Sequard Syndrome	2.6%
697	Lissencephaly	2.6%
698	Polymicrogyria	2.6%
699	Pachygyria	2.6%
700	Schizencephaly	2.6%
701	Lockjaw	2.6%
702	Allodynia	2.6%
703	Lead Poisoning, Nervous System, Childhood	2.6%
704	Lead Poisoning, Nervous System, Adult	2.6%
705	Periventricular Nodular Heterotopia	2.6%
706	Ageusia	2.6%
707	Myalgia	2.5%
708	Autistic Disorder	2.4%
709	Neuronal Ceroid-Lipofuscinoses	2.4%
710	Asperger Syndrome	2.4%
711	Polyradiculopathy	2.4%
712	Optic Atrophy, Hereditary, Leber	2.3%
713	Eye Injuries	2.2%
714	Kearns-Sayre syndrome	2.2%
715	Aicardi's syndrome	2.2%
716	Hoarseness	2.2%
717	Muscular Dystrophy	2.2%
718	Congenital nystagmus	2.2%
719	Orbital Myositis	2.2%
720	Neurofibrosarcoma	2.2%
721	Cockayne Syndrome	2.2%
722	Diplopia	2.2%
723	Muscle Rigidity	2.2%
724	Muscle Spasticity	2.2%
725	Scotoma	2.2%
726	Photophobia	2.2%
727	Cogwheel Rigidity	2.2%
728	Hemifacial Spasm	2.2%
729	Amaurosis	2.2%
730	Blindness	2.2%
731	Nuchal Rigidity	2.2%
732	Binge Drinking	2.2%
733	Pyomyositis	2.2%
734	Agnosia	2.2%
735	Apraxias	2.2%
736	Hallucinations	2.2%
737	Hemianopsia	2.2%
738	Hyperacusis	2.2%
739	Tinnitus	2.2%
740	Visual Agnosia	2.2%
741	Anosognosia	2.2%
742	Wernicke-Korsakoff Syndrome	2.2%
743	Phonophobia	2.2%
744	Hearing Loss	2.2%
745	Sarcopenia	2.2%
746	Holoprosencephaly	2%
747	Sleep Apnea, Obstructive	1.9%
748	Sleep Apnea, Central	1.9%
749	Trigeminal Neuralgia	1.9%
750	Agraphia	1.9%
751	Anomia	1.9%
752	Cluttering	1.9%
753	Language Development Disorders	1.9%
754	Speech Disorders	1.9%
755	Syncope	1.9%
756	Stupor	1.9%
757	Dysgraphia	1.9%
758	Presyncope	1.9%
759	Dyslalia	1.9%
760	Color blindness	1.9%
761	Cri-du-Chat Syndrome	1.9%
762	Down Syndrome	1.9%
763	Trisomy 21	1.9%
764	POEMS Syndrome	1.9%
765	Meningioma	1.9%
766	Williams Syndrome	1.9%
767	Microcephaly	1.9%
768	Macrocephaly	1.9%
769	Diurnal Enuresis	1.9%
770	Hypokalemic periodic paralysis	1.9%
771	Porencephaly	1.8%
772	Eye Burns	1.6%
773	Prader-Willi Syndrome	1.6%
774	Welander Distal Myopathy	1.6%
775	Amaurosis Fugax	1.6%
776	Blindness, Cortical	1.6%
777	Phantom pain	1.6%
778	Phantom Limb Pain	1.6%
779	Rett Syndrome	1.6%
780	Deafness	1.6%
781	Hearing Loss, Sudden	1.6%
782	Gerstmann Syndrome	1.6%
783	Hearing Loss, Bilateral	1.6%
784	Hearing Loss, High-Frequency	1.6%
785	Hearing Loss, Mixed Conductive-Sensorineural	1.6%
786	Prosopagnosia	1.6%
787	Apraxia, Ideomotor	1.6%
788	Charles Bonnet Syndrome	1.6%
789	Hearing Loss, Unilateral	1.6%
790	Complete Hearing Loss	1.6%
791	Alien Hand Syndrome	1.6%
792	Deaf Mutism	1.6%
793	Aphasia	1.6%
794	Articulation Disorders	1.6%
795	Echolalia	1.6%
796	Stuttering	1.6%
797	Dysphasia	1.6%
798	Dysarthria	1.4%
799	Dermatomyositis	1.4%
800	Corneal Scar	1.4%
801	Muscular Dystrophy, Duchenne	1.4%
802	Rubinstein-Taybi Syndrome	1.3%
803	Fragile X Syndrome	1.2%
804	Corneal Perforation	1.2%
805	Mucopolysaccharidosis II	0.9%

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