MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Congenital Microtia

(UMLS:C3850155)

Definition:: Malformation of external portion of EAR AURICLE.
UMLS ID:: C3850155
MeSH ID:: D065817

Classification 1:

Name:

Otorhinolaryngologic Diseases
MeSH Tree Number(s):: C09.218.235

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.287

Synonym(s)

Congenital Microtia

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Isotretinoin		3162101 11105626	CTD
2	Tretinoin		9535508	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Labyrinthitis	31%
2	Beckwith-Wiedemann Syndrome	28.8%
3	Wolf-Hirschhorn Syndrome	28.8%
4	Abnormalities, Drug-Induced	28.6%
5	Otosclerosis	28.6%
6	Situs Inversus	28.6%
7	Tympanosclerosis	28.6%
8	Holoprosencephaly	26.9%
9	Smith-Magenis syndrome	24.1%
10	Cri-du-Chat Syndrome	23.7%
11	Down Syndrome	23.7%
12	Trisomy 21	23.7%
13	Anencephaly	22.4%
14	Ear Neoplasms	22.4%
15	Eye Abnormalities	22.2%
16	Tympanic Membrane Perforation	22.2%
17	Cardiovascular Abnormalities	22.2%
18	Aicardi's syndrome	21.9%
19	Otomycosis	21.4%
20	Skin Abnormalities	21.4%
21	Lymphatic Abnormalities	21.4%
22	Rubinstein-Taybi Syndrome	21.2%
23	Cochlear Diseases	20.9%
24	Otitis Externa	20.9%
25	Otitis Media	20.9%
26	Prune Belly Syndrome	20.9%
27	Twins, Conjoined	20.9%
28	Vestibular Diseases	20.9%
29	Endolymphatic Hydrops	20.9%
30	Waardenburg Syndrome	20.9%
31	Congenital diaphragmatic hernia	20.9%
32	Ectodermal Dysplasia	20.4%
33	Aplasia Cutis Congenita	20.4%
34	Prader-Willi Syndrome	20.2%
35	Primary Ciliary Dyskinesia	20%
36	Kartagener Syndrome	19.5%
37	Maxillofacial Abnormalities	18.9%
38	Dural Arteriovenous Fistula	18.9%
39	Dextrocardia	18.6%
40	Laryngostenosis	18.3%
41	CHARGE Syndrome	18.1%
42	Urogenital Abnormalities	17.6%
43	Meniere Disease	17.2%
44	Otitis Media with Effusion	17.2%
45	Dysacusis	16.6%
46	Microcephaly	15.9%
47	Macrocephaly	15.9%
48	Vestibulocochlear Nerve Diseases	15.8%
49	Anophthalmos	15.8%
50	Anus, Imperforate	15.8%
51	Hydranencephaly	15.8%
52	Microphthalmos	15.8%
53	Neural Tube Defects	15.8%
54	Tethered Cord Syndrome	15.8%
55	Iniencephaly	15.8%
56	Craniorachischisis	15.8%
57	Limb Deformities, Congenital	15.8%
58	Exencephaly	15.8%
59	Septo-Optic Dysplasia	15.8%
60	Craniofacial Abnormalities	15.8%
61	Cortical Dysplasia	15.8%
62	Malformations of Cortical Development	15.8%
63	Anorectal Malformations	15.8%
64	Marfan Syndrome	15.6%
65	Bloom Syndrome	15.5%
66	Choanal Atresia	15.3%
67	Laryngocele	15.3%
68	Nail-Patella Syndrome	15.1%
69	Genetic Diseases, Inborn	15%
70	Xeroderma	14.9%
71	Mobius Syndrome	14.9%
72	Porencephaly	14.9%
73	Classical Lissencephalies and Subcortical Band Heterotopias	14.7%
74	Acrocephalosyndactylia	14.6%
75	Craniosynostosis	14.3%
76	Syndactyly	14.3%
77	Brachycephaly	14.3%
78	Scimitar Syndrome	14.3%
79	Fragile X Syndrome	14.2%
80	Alstrom Syndrome	13.8%
81	Herpes Zoster Oticus	13.7%
82	Polycystic Kidney Diseases	13.4%
83	Williams Syndrome	13.4%
84	Turner Syndrome	13%
85	Laryngomalacia	13%
86	Amelia	12.8%
87	Arachnodactyly	12.8%
88	Ectopia Cordis	12.8%
89	Ectromelia	12.8%
90	Hemimelia	12.8%
91	Meningomyelocele	12.8%
92	Phocomelia	12.8%
93	Sirenomelia	12.8%
94	Spina Bifida	12.8%
95	Polydactyly	12.8%
96	Brachydactyly	12.8%
97	Plagiocephaly	12.8%
98	Lower Extremity Deformities, Congenital	12.8%
99	Upper Extremity Deformities, Congenital	12.8%
100	Vestibular Neuronitis	12.8%
101	Single umbilical artery	12.8%
102	Noonan Syndrome	12.7%
103	Poland Syndrome	12.7%
104	Blepharophimosis	12.7%
105	Mouth Abnormalities	12.7%
106	Cockayne Syndrome	12.7%
107	Esophageal Atresia	12.5%
108	Intestinal Atresia	12.5%
109	Horseshoe Kidney	12.5%
110	Pectus excavatum	12.5%
111	Klippel-Feil Syndrome	12.4%
112	Gastroschisis	12.4%
113	Synostosis	12.4%
114	Cleft Palate	12.4%
115	Acrodermatitis	12.3%
116	Lymphangiectasis, Intestinal	12.3%
117	Gianotti-Crosti Syndrome	12.3%
118	Hyperacusis	12.1%
119	Tinnitus	12.1%
120	Phonophobia	12.1%
121	Hearing Loss	12.1%
122	Jaw Abnormalities	12.1%
123	Retinal Dysplasia	12%
124	Aniridia	11.9%
125	Epidermolysis Bullosa	11.7%
126	Abnormalities, Radiation-Induced	11.6%
127	Smith-Lemli-Opitz Syndrome	11.6%
128	Laryngeal Diseases	11.5%
129	Nose Diseases	11.5%
130	Pharyngeal Diseases	11.5%
131	Klinefelter Syndrome	11.5%
132	Ichthyosis, X-Linked	11.5%
133	Dermal Sinus	11.4%
134	Spina Bifida Cystica	11.4%
135	Spina Bifida Occulta	11.4%
136	Lissencephaly	11.4%
137	Polymicrogyria	11.4%
138	Pachygyria	11.4%
139	Schizencephaly	11.4%
140	Periventricular Nodular Heterotopia	11.4%
141	Fetal Diseases	11.1%
142	Polycystic Kidney, Autosomal Dominant	11%
143	Micrognathism	10.9%
144	Pierre Robin Syndrome	10.9%
145	Arthrogryposis	10.6%
146	Tracheobronchomegaly	10.6%
147	Choledochal Cyst	10.5%
148	Hermaphroditism	10.5%
149	Disorders of Sex Development	10.5%
150	Cryptorchidism	10.3%
151	Vertigo	10.3%
152	Hypospadias	10.3%
153	Central Nervous System Cysts	10.3%
154	Dandy-Walker Syndrome	10.2%
155	Aortic coarctation	10.2%
156	Cor Triatriatum	10.2%
157	Coronary Vessel Anomalies	10.2%
158	Dental Enamel Hypoplasia	10.2%
159	Patent ductus arteriosus	10.2%
160	Ebstein Anomaly	10.2%
161	Heart Septal Defects	10.2%
162	Hypodontia	10.2%
163	Macrostomia	10.2%
164	Meningocele	10.2%
165	Microstomia	10.2%
166	Tetralogy of Fallot	10.2%
167	Transposition of Great Vessels	10.2%
168	Hypoplastic Left Heart Syndrome	10.2%
169	May-Thurner Syndrome	10.2%
170	Encephalocele	10.2%
171	Craniofacial Dysostosis	10.1%
172	POEMS Syndrome	10.1%
173	Mastoiditis	10.1%
174	Wolff-Parkinson-White Syndrome	10.1%
175	Petrositis	10.1%
176	Deafness	10%
177	Hearing Loss, Sudden	10%
178	Hearing Loss, Bilateral	10%
179	Hearing Loss, High-Frequency	10%
180	Hearing Loss, Mixed Conductive-Sensorineural	10%
181	Hearing Loss, Unilateral	10%
182	Complete Hearing Loss	10%
183	Deaf Mutism	10%
184	Retrognathia	9.7%
185	Hyperkeratosis, Epidermolytic	9.7%
186	Abdominal Cramps	9.5%
187	Amniotic Band Syndrome	9.5%
188	Asphyxia Neonatorum	9.5%
189	Cystic Fibrosis	9.5%
190	Infant, Premature, Diseases	9.5%
191	Infantile Colic	9.5%
192	Charcot-Marie-Tooth Disease	9.5%
193	Antley-Bixler Syndrome Phenotype	9.5%
194	Sjogren-Larsson Syndrome	9.5%
195	Pharyngeal Neoplasms	9.4%
196	Pseudoxanthoma Elasticum	9.1%
197	Aortopulmonary Septal Defect	9%
198	Double Outlet Right Ventricle	9%
199	Endocardial Cushion Defects	9%
200	Myocardial bridging	9%
201	Aorticopulmonary Septal Defect	9%
202	Kallmann Syndrome	9%
203	Pectus carinatum	8.9%
204	Hyperandrogenism	8.8%
205	Bladder Exstrophy	8.8%
206	Epispadias	8.8%
207	Multicystic Dysplastic Kidney	8.7%
208	Prognathism	8.7%
209	Long QT Syndrome	8.5%
210	Platybasia	8.5%
211	Tricuspid Atresia	8.5%
212	Arrhythmogenic Right Ventricular Dysplasia	8.5%
213	Truncus Arteriosus, Persistent	8.5%
214	Goldenhar Syndrome	8.4%
215	Gonadal Dysgenesis	8.4%
216	Bronchomalacia	8.4%
217	Adrenogenital Syndrome	8.4%
218	Tracheomalacia	8.4%
219	Ovotesticular Disorders of Sex Development	8.4%
220	Xeroderma Pigmentosum	8.2%
221	Laryngeal neoplasm	8%
222	Meconium Aspiration Syndrome	8%
223	Tuberous Sclerosis	8%
224	Zellweger Syndrome	7.7%
225	Nasopharyngeal Neoplasms	7.6%
226	Refsum Disease	7.6%
227	Mandibulofacial Dysostosis	7.5%
228	Romano-Ward Syndrome	7.5%
229	Neoplastic Syndromes, Hereditary	7.4%
230	Basal Cell Nevus Syndrome	7.3%
231	Granuloma, Lethal Midline	7.1%
232	Laryngeal Edema	7.1%
233	Nose Deformities, Acquired	7.1%
234	Talipes	7.1%
235	Anemia, Neonatal	7%
236	Deglutition Disorders	7%
237	Multiple Epiphyseal Dysplasia	7%
238	Osteochondrodysplasias	7%
239	Pelger-Huet Anomaly	7%
240	Persistent Fetal Circulation Syndrome	7%
241	Werner Syndrome	7%
242	Myasthenic Syndromes, Congenital	7%
243	Familial Mediterranean Fever	7%
244	Umbilical hernia	6.9%
245	Acoustic Neuroma	6.9%
246	Congenital clubfoot	6.8%
247	Vertical Talus	6.8%
248	Anemia, Sickle Cell	6.8%
249	Hypopharyngeal Neoplasms	6.8%
250	Thalassemia	6.8%
251	Hypopharyngeal Cancer	6.8%
252	Paranasal Sinus Neoplasms	6.7%
253	Muscular Dystrophy, Duchenne	6.7%
254	Rett Syndrome	6.7%
255	Albinism	6.4%
256	Auditory Perceptual Disorders	6.2%
257	Mucopolysaccharidosis II	6.2%
258	Nose Neoplasms	6.1%
259	Nasopharyngitis	5.8%
260	Dwarfism	5.8%
261	Laryngitis	5.7%
262	Neonatal Abstinence Syndrome	5.7%
263	Pharyngitis	5.7%
264	Rhinitis	5.7%
265	Vocal Cord Dysfunction	5.7%
266	Nasal Polyps	5.6%
267	Arteriovenous fistula	5.6%
268	Fetal Growth Retardation	5.6%
269	Sickle Cell Trait	5.5%
270	Tonsillar Neoplasms	5.5%
271	Muscular Dystrophy	5.5%
272	Osteogenesis Imperfecta	5.5%
273	Fetal Hypoxia	5.5%
274	Congenital nystagmus	5.5%
275	Fetal Alcohol Spectrum Disorders	5.5%
276	Maxillary Sinus Neoplasms	5.5%
277	Nasopharyngeal carcinoma	5.5%
278	Menkes Kinky Hair Syndrome	5.5%
279	Toxoplasmosis, Congenital	5.5%
280	Syphilis, Congenital	5.4%
281	Paralysis, Obstetric	5.3%
282	Retinopathy of Prematurity	5.3%
283	Amino Acid Metabolism, Inborn Errors	5.2%
284	Carbohydrate Metabolism, Inborn Errors	5.2%
285	Croup	5.2%
286	Metal Metabolism, Inborn Errors	5.2%
287	Progeria	5.2%
288	Rhinitis, Vasomotor	5.2%
289	Lysosomal Storage Diseases	5.2%
290	Cytochrome-c Oxidase Deficiency	5.2%
291	Peroxisomal Disorders	5.2%
292	Bronchopulmonary Dysplasia	5.1%
293	Wiskott-Aldrich Syndrome	5%
294	Neuronal Ceroid-Lipofuscinoses	5%
295	Voice Disorders	4.7%
296	Voice Disturbance	4.7%
297	Epistaxis	4.7%
298	Autoimmune Lymphoproliferative Syndrome	4.7%
299	Congenital Hyperinsulinism	4.6%
300	Chorioamnionitis	4.6%
301	Angioedemas, Hereditary	4.5%
302	Myotonic Dystrophy	4.5%
303	Adrenoleukodystrophy	4.4%
304	Glycogen storage disease type II	4.4%
305	Fabry Disease	4.3%
306	Denys-Drash Syndrome	4.3%
307	Alkaptonuria	4.2%
308	Glycogen Storage Disease	4.2%
309	Hypophosphatasia	4.2%
310	Propionic acidemia	4.2%
311	Dihydropyrimidine Dehydrogenase Deficiency	4.2%
312	Cystinosis	4.2%
313	Mucopolysaccharidosis III	4.2%
314	Respiratory Distress Syndrome, Newborn	4.2%
315	Acute Chest Syndrome	4.2%
316	Cutis Laxa	4.2%
317	Sinusitis	4.2%
318	Retinitis Pigmentosa	4.1%
319	Pigmentary retinopathy	4.1%
320	Galactosemias	4.1%
321	Urea Cycle Disorders, Inborn	4.1%
322	Tyrosinemias	4.1%
323	Laryngospasm	4.1%
324	Tonsillitis	4.1%
325	Porokeratosis	4.1%
326	Keratoderma, Palmoplantar	4.1%
327	Hepatolenticular Degeneration	4.1%
328	Chronic granulomatous disease	4.1%
329	Amyloid Neuropathies, Familial	4%
330	Welander Distal Myopathy	4%
331	Granuloma, Laryngeal	4%
332	Vocal Cord Paralysis	3.9%
333	Hydrops Fetalis	3.9%
334	Glycogen Storage Disease Type I	3.8%
335	Glycogen Storage Disease Type V	3.8%
336	Gaucher Disease	3.7%
337	Optic Atrophy, Hereditary, Leber	3.7%
338	Hyperphosphaturia	3.7%
339	Tay-Sachs Disease	3.5%
340	Homocystinuria	3.5%
341	Duane Retraction Syndrome	3.5%
342	Leigh Disease	3.5%
343	Canavan Disease	3.5%
344	Alexander Disease	3.5%
345	Porphyrias, Hepatic	3.4%
346	Hyaline Membrane Disease	3.4%
347	Peutz-Jeghers Syndrome	3.4%
348	Aphonia	3.4%
349	Myotonia Congenita	3.4%
350	Thrombasthenia	3.4%
351	Retropharyngeal Abscess	3.4%
352	Antithrombin III Deficiency	3.4%
353	Protein C Deficiency	3.4%
354	Brain Diseases, Metabolic, Inborn	3.4%
355	Dysphonia	3.4%
356	Afibrinogenemia	3.4%
357	Dystonia Musculorum Deformans	3.4%
358	Factor VII Deficiency	3.4%
359	Factor X Deficiency	3.4%
360	Factor XII Deficiency	3.4%
361	Hemophilia A	3.4%
362	Leukomalacia, Periventricular	3.4%
363	Activated Protein C Resistance	3.4%
364	Factor II deficiency	3.4%
365	Factor VIII Deficiency	3.4%
366	Factor V deficiency	3.4%
367	Factor XI Deficiency	3.4%
368	Hypoprothrombinemias	3.4%
369	Lemierre Syndrome	3.4%
370	Hypolipoproteinemias	3.4%
371	Papillon-Lefevre Disease	3.4%
372	Fanconi Anemia	3.4%
373	Nesidioblastosis	3.4%
374	Hyperlipidemia, Familial Combined	3.3%
375	Hyperlipoproteinemia Type III	3.3%
376	Lafora Disease	3.3%
377	Unverricht-Lundborg Syndrome	3.3%
378	Ophthalmia Neonatorum	3.3%
379	Anemia, Diamond-Blackfan	3.3%
380	Niemann-Pick Disease, Type C	3.3%
381	Carbamoyl-Phosphate Synthase I Deficiency Disease	3.3%
382	Ataxia Telangiectasia	3%
383	Rhinoscleroma	3%
384	Multiple Endocrine Neoplasia	3%
385	Hypoalphalipoproteinemias	3%
386	Congenital Hypothyroidism	2.9%
387	Dermatitis, Atopic	2.9%
388	Familial Periodic Paralysis	2.8%
389	Lactose Intolerance	2.8%
390	Variegate Porphyria	2.8%
391	Acute intermittent porphyria	2.8%
392	Porphyria Cutanea Tarda	2.8%
393	Hay fever	2.8%
394	Rhinitis, Allergic, Perennial	2.8%
395	Hyperhomocysteinemia	2.8%
396	Peritonsillar Abscess	2.8%
397	Renal Aminoacidurias	2.8%
398	Fanconi Syndrome	2.8%
399	Pseudohypoaldosteronism	2.8%
400	Liddle Syndrome	2.8%
401	Hyperlipoproteinemia Type IV	2.8%
402	Hyperlipoproteinemia Type V	2.8%
403	Hoarseness	2.6%
404	Kernicterus	2.6%
405	Behcet Syndrome	2.5%
406	Hypokalemic periodic paralysis	2.5%
407	Cystinuria	2.5%
408	Gout	2.4%
409	Multiple Endocrine Neoplasia Type 1	2.4%
410	Pseudohypoparathyroidism	2.4%
411	Friedreich Ataxia	2.4%
412	Renal tubular acidosis	2.4%
413	Huntington Disease	2.2%
414	Arthritis, Gouty	2.1%
415	Familial Hypophosphatemic Rickets	2.1%
416	Nephroblastoma	2%
417	Glycosuria, Renal	1.8%
418	Adenomatous Polyposis Coli	1.8%
419	MELAS Syndrome	1.5%

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