MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Medial Tibial Stress Syndrome

(UMLS:C1696469)

Definition:: SKELETAL MUSCLE pain and tenderness along the posteromedial TIBIA resulting from exercise such as running and other physical activity.
UMLS ID:: C1696469
MeSH ID:: D058923

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.651.426

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.668.491.087

Classification 3:

Name:

Wounds and Injuries
MeSH Tree Number(s):: C26.558.705

Synonym(s)

Medial Tibial Stress Syndrome

Medial tibial stress syndrome

SHIN SPLINTS

Shin splints

injury shin splints

shin splint

shin splint injury

shin splints

splints shin

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Teriparatide	FAERS: 26	US FAERS
2	Methotrexate	FAERS: 4	US FAERS
3	Zoledronic Acid	FAERS: 4	US FAERS
4	Rosuvastatin Calcium	FAERS: 3	US FAERS
5	Insulin Detemir	FAERS: 2	US FAERS
6	Isotretinoin	FAERS: 2	US FAERS
7	Levofloxacin	FAERS: 2	US FAERS
8	Pregabalin	FAERS: 2	US FAERS
9	Terbinafine	FAERS: 2	US FAERS
10	Atorvastatin	FAERS: 1	US FAERS
11	Cabozantinib S-malate	FAERS: 1	US FAERS
12	Dimethyl Fumarate	FAERS: 1	US FAERS
13	Estradiol	FAERS: 1	US FAERS
14	Ibandronic Acid	FAERS: 1	US FAERS
15	Ibuprofen	FAERS: 1	US FAERS
16	Lenalidomide	FAERS: 1	US FAERS
17	Methotrexate	FAERS: 1	US FAERS
18	Nelfinavir	FAERS: 1	US FAERS
19	NuvaRing	FAERS: 1	US FAERS
20	Rivaroxaban	FAERS: 1	US FAERS
21	Ruxolitinib phosphate	FAERS: 1	US FAERS
22	Simcor	FAERS: 1	US FAERS
23	Simvastatin	FAERS: 1	US FAERS
24	Tadalafil	FAERS: 1	US FAERS
25	Valsartan	FAERS: 1	US FAERS
26	pazopanib	FAERS: 1	US FAERS
27	Orlistat		OFFSIDES
28	Rosuvastatin Calcium	Canada Vigilance: 1	Canada Vigilance

Similar ADE(s)

	Name	Semantic Similarity
1	Myositis	36.1%
2	Myotonic Disorders	36.1%
3	Fibromyalgia	34.9%
4	Mitochondrial Myopathies	29.9%
5	Eosinophilia-Myalgia Syndrome	29.7%
6	Polymyositis	26.5%
7	Familial Periodic Paralysis	25.2%
8	Myotonic Dystrophy	25.2%
9	Isaacs syndrome	25%
10	Chronic Fatigue Syndrome	23.5%
11	Contracture	22.5%
12	Femoral Fractures	22.5%
13	Tendinitis	22.5%
14	Tibial Fractures	22.5%
15	Tendinopathy	22.5%
16	Muscular Dystrophy	22.3%
17	Orbital Myositis	22.3%
18	Pyomyositis	22%
19	Myalgia	21.9%
20	Knee Injuries	21.1%
21	Myofascial Pain Syndromes	21.1%
22	Rhabdomyolysis	21.1%
23	Foot Injuries	21.1%
24	Myotonia Congenita	20.8%
25	Ischemic contracture	20.4%
26	Arthrogryposis	20%
27	Polymyalgia Rheumatica	18.6%
28	Hypokalemic periodic paralysis	18.6%
29	Hip Fractures	18.4%
30	Welander Distal Myopathy	18.2%
31	Mitochondrial Encephalomyopathies	17.6%
32	Compartment syndromes	16.9%
33	Motor Neuron Disease	16.9%
34	Hip Contracture	16.4%
35	Enthesopathy	16.4%
36	Iliotibial Band Syndrome	16.4%
37	Trauma, Nervous System	16.4%
38	Temporomandibular Joint Dysfunction Syndrome	16.2%
39	Muscle Cramp	16%
40	Dermatomyositis	15.9%
41	Neuromuscular Junction Diseases	15.8%
42	Peripheral Nervous System Diseases	15.8%
43	Muscular Dystrophy, Duchenne	15.6%
44	Fibrodysplasia Ossificans Progressiva	15.5%
45	Myoglobinuria	15.5%
46	Myositis Ossificans	15.5%
47	Tenosynovitis	15.5%
48	Muscle Rigidity	15.3%
49	Muscle Spasticity	15.3%
50	Cogwheel Rigidity	15.3%
51	Nuchal Rigidity	15.3%
52	Peripheral Nerve Injuries	15.1%
53	Frostbite	14.5%
54	Stiff-Person Syndrome	13.9%
55	Muscle Weakness	13.8%
56	Temporomandibular Joint Disorders	13.5%
57	Spinal Cord Injuries	13.1%
58	Hip Dislocation	12.8%
59	Shoulder Dislocation	12.8%
60	Hip Dysplasia	12.8%
61	Carpal Tunnel Syndrome	12.6%
62	Complex Regional Pain Syndromes	12.5%
63	Causalgia	12.4%
64	Anterior Compartment Syndrome	12.3%
65	Abdominal Compartment Syndrome	12.3%
66	Brachial Plexus Neuritis	12.2%
67	Neuralgic Amyotrophy	12.2%
68	Musculoskeletal Pain	11.7%
69	Poliomyelitis	11.6%
70	Guillain-Barre Syndrome	11.5%
71	Spinal Muscular Atrophy	11.4%
72	Progressive Muscular Atrophy	11.4%
73	Crush syndrome	11.3%
74	Osteoarthropathy, Secondary Hypertrophic	11.3%
75	Fasciitis, Plantar	11.3%
76	Tarsal Tunnel Syndrome	11.1%
77	Cubital Tunnel Syndrome	11.1%
78	Cauda Equina Syndrome	11.1%
79	Progressive bulbar palsy	11%
80	Bulbar palsy	11%
81	Athletic Injuries	10.9%
82	Bone Diseases	10.9%
83	Fasciitis	10.9%
84	Foot Deformities	10.9%
85	Hand Injuries	10.9%
86	Arthropathy	10.9%
87	Soft Tissue Injuries	10.9%
88	Sprain	10.9%
89	Sprains and Strains	10.9%
90	Tendon Injuries	10.9%
91	Laceration	10.9%
92	Wounds, Penetrating	10.9%
93	Heat Cramps	10.9%
94	Rupture	10.9%
95	Myasthenia Gravis	10.3%
96	Neuritis	10.3%
97	Polyneuritis	10.3%
98	Polyradiculoneuropathy	10.3%
99	Radiculitis	10.3%
100	Polyneuropathy	10.3%
101	Mononeuritis	10.3%
102	Mononeuropathies	10.3%
103	Brachial Plexus Neuropathies	10.3%
104	Radiculopathy	10.3%
105	Mononeuropathy Multiplex	10.3%
106	Nerve Root Compression	10.3%
107	Polyradiculoneuritis	10.3%
108	Dupuytren Contracture	10.2%
109	MELAS Syndrome	10.2%
110	Amyotrophic Lateral Sclerosis	10.1%
111	Craniocerebral Trauma	9.9%
112	Osteoarthritis, Spine	9.8%
113	Chilblains	9.7%
114	Spinal Fractures	9.7%
115	Pectus carinatum	9.5%
116	Kearns-Sayre syndrome	9.4%
117	Osteochondritis	9.3%
118	Splenic Rupture	9.3%
119	Metatarsalgia	9.2%
120	Sciatica	9.2%
121	Cranial nerve diseases	9.1%
122	Demyelinating Diseases	9.1%
123	Demyelination	9.1%
124	Chronobiology Disorders	9.1%
125	Jaw Diseases	9%
126	Reflex Sympathetic Dystrophy	8.8%
127	Botulism	8.8%
128	Bites and Stings	8.7%
129	Cartilage Diseases	8.7%
130	Extravasation of Diagnostic and Therapeutic Materials	8.7%
131	Foot Diseases	8.7%
132	Platybasia	8.7%
133	Rheumatism	8.7%
134	Chondromalacia	8.7%
135	Vascular System Injuries	8.7%
136	Tympanic Membrane Perforation	8.7%
137	Tooth Injuries	8.7%
138	Miller Fisher Syndrome	8.7%
139	Brain Concussion	8.6%
140	Asphyxia	8.6%
141	Esophageal Perforation	8.6%
142	Shock, Traumatic	8.6%
143	Central Cord Syndrome	8.6%
144	Self Mutilation	8.5%
145	Eye Burns	8.5%
146	Gout	8.5%
147	Acrodynia	8.4%
148	Conus Medullaris Syndrome	8.3%
149	Myasthenic Syndromes, Congenital	8.3%
150	Lambert-Eaton Myasthenic Syndrome	8.3%
151	Multiple System Atrophy	8.3%
152	Ankylosing spondylitis	8.2%
153	Diabetic Neuropathies	8.2%
154	Periarthritis	8.2%
155	Diabetic Amyotrophy	8.2%
156	Diabetic Autonomic Neuropathy	8.2%
157	Pneumocephalus	8.2%
158	Neuralgia	8.2%
159	Neuropathic pain	8.2%
160	Pectus excavatum	8%
161	Rheumatic Fever	8%
162	Brain Injuries	8%
163	Talipes	7.9%
164	Sciatic Neuropathy	7.7%
165	Ulnar Neuropathies	7.7%
166	Lesion of Sciatic Nerve	7.7%
167	Olfactory Nerve Injuries	7.7%
168	Ulnar Neuritis	7.7%
169	Radial nerve compression	7.7%
170	Radial Tunnel Syndrome	7.7%
171	Peroneal Neuropathies	7.7%
172	Radial Neuropathy	7.7%
173	Median Neuropathy	7.7%
174	Sciatic Nerve Palsy	7.7%
175	Femoral Neuropathy	7.7%
176	Tibial Neuropathy	7.7%
177	Ulnar Nerve Palsy	7.7%
178	Radial nerve palsy	7.7%
179	Osteoarthritis, Knee	7.5%
180	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	7.4%
181	Klippel-Feil Syndrome	7.4%
182	Synostosis	7.4%
183	Brain Contusion	7.4%
184	Restless Legs Syndrome	7.3%
185	Nervous System Neoplasms	7.2%
186	Neurologic Manifestations	7.2%
187	Neurotoxicity Syndromes	7.2%
188	Ocular Motility Disorders	7.2%
189	Cyclophoria	7.2%
190	Hand-Arm Vibration Syndrome	7.1%
191	Acrocephalosyndactylia	7.1%
192	Drowning	7.1%
193	Arthritis	7%
194	Human Bite	7%
195	Bone Diseases, Developmental	7%
196	Bursitis	7%
197	Contusions	7%
198	Decompression Sickness	7%
199	Finger Injuries	7%
200	Flail Chest	7%
201	Fractures, Closed	7%
202	Pathological fracture	7%
203	Heart Injuries	7%
204	Heat Exhaustion	7%
205	Heat Stroke	7%
206	Hyperostosis	7%
207	Joint Instability	7%
208	Osteitis	7%
209	Osteitis Deformans	7%
210	Osteochondrosis	7%
211	Spinal Diseases	7%
212	Synovitis	7%
213	Joint laxity	7%
214	Decapitation	7%
215	Ankle Fracture	7%
216	Polyarthritis	7%
217	Frozen shoulder	7%
218	Avulsion fracture	7%
219	Compression fracture	7%
220	Osteoporotic Fractures	7%
221	Patellofemoral Pain Syndrome	7%
222	Arthritis, Psoriatic	7%
223	Brain Hemorrhage, Traumatic	7%
224	Encephalomyelitis	6.9%
225	Prion Diseases	6.9%
226	Autonomic Dysreflexia	6.9%
227	Rheumatoid Arthritis	6.9%
228	Juvenile arthritis	6.9%
229	Coma, Post-Head Injury	6.9%
230	Craniosynostosis	6.9%
231	Syndactyly	6.9%
232	Brachycephaly	6.9%
233	Facial Injuries	6.8%
234	Subacute Combined Degeneration	6.8%
235	Gigantism	6.8%
236	Spinal Neoplasms	6.8%
237	Spondylitis	6.8%
238	Ophthalmoplegic Migraine	6.8%
239	Splenosis	6.8%
240	Congenital clubfoot	6.7%
241	Vertical Talus	6.7%
242	Meningoencephalitis	6.7%
243	Facial Nerve Injuries	6.7%
244	Epilepsy, Post-Traumatic	6.7%
245	Arthritis, Gouty	6.6%
246	Arthritis, Reactive	6.5%
247	Parkinson Disease	6.5%
248	Spondylarthropathies	6.4%
249	Polyradiculopathy	6.4%
250	Myasthenia Gravis, Autoimmune, Experimental	6.3%
251	Neuritis, Autoimmune, Experimental	6.2%
252	Thoracic Outlet Syndrome	6.2%
253	Marchiafava-Bignami Disease	6.2%
254	Craniofacial Dysostosis	6.2%
255	Rheumatoid Nodule	6.2%
256	Brain Injuries, Diffuse	6.1%
257	Traumatic Brain Injury	6.1%
258	Lewy Body Disease	6.1%
259	Sleep Wake Disorders	6.1%
260	Charcot-Marie-Tooth Disease	6%
261	Striatonigral Degeneration	6%
262	Radiation injury	5.9%
263	Poland Syndrome	5.9%
264	neurofibroma	5.8%
265	Dandy-Walker Syndrome	5.8%
266	Bone Diseases, Endocrine	5.8%
267	Asterixis	5.7%
268	Ballismus	5.7%
269	Cerebrospinal Fluid Otorrhea	5.7%
270	Cerebrospinal Fluid Rhinorrhea	5.7%
271	Progressive supranuclear palsy	5.7%
272	Bone Diseases, Infectious	5.6%
273	Bone neoplasms	5.6%
274	Maxillary Diseases	5.6%
275	Osteopenia	5.6%
276	Lung Injury	5.6%
277	Leukoencephalitis, Acute Hemorrhagic	5.6%
278	Discitis	5.6%
279	Bone Resorption	5.6%
280	Foreign-Body Reaction	5.6%
281	Hemarthrosis	5.6%
282	Insect Bites and Stings	5.6%
283	Paralysis, Obstetric	5.6%
284	Sunburn	5.6%
285	Tietze's Syndrome	5.6%
286	Tooth Avulsion	5.6%
287	Limb Deformities, Congenital	5.6%
288	Craniofacial Abnormalities	5.6%
289	Aseptic Necrosis of Bone	5.6%
290	Carotid Artery Injuries	5.5%
291	Near Drowning	5.5%
292	Osteoradionecrosis	5.5%
293	Myelitis	5.5%
294	Myelitis, Transverse	5.5%
295	Felty Syndrome	5.3%
296	Epidural Abscess	5.3%
297	Brain Diseases	5.3%
298	Dysautonomia	5.3%
299	Meningitis	5.3%
300	Movement Disorders	5.3%
301	Pachymeningitis	5.3%
302	Spinal Cord Diseases	5.3%
303	Vagus Nerve Disorder	5.3%
304	Glossopharyngeal Neuralgia	5.3%
305	Abducens Nerve Diseases	5.3%
306	Heavy Metal Poisoning, Nervous System	5.3%
307	Diffuse Axonal Injury	5.3%
308	Tauopathies	5.3%
309	Trochlear Nerve Diseases	5.3%
310	Shy-Drager Syndrome	5.2%
311	Vertebral Artery Dissection	5.2%
312	MPTP Poisoning	5.2%
313	Ainhum	5.2%
314	Bunion	5.2%
315	Dysostoses	5.2%
316	Pseudarthrosis	5.2%
317	Smoke Inhalation Injury	5.2%
318	Spinal Stenosis	5.2%
319	Spondylosis	5.2%
320	Intervertebral Disc Degeneration	5.2%
321	Sacroiliitis	5.2%
322	Neuroleptic Malignant Syndrome	5.1%
323	Myelinolysis, Central Pontine	5.1%
324	Neuromyelitis Optica	5.1%
325	Opsoclonus-Myoclonus Syndrome	5.1%
326	Sleep Disorders, Circadian Rhythm	5.1%
327	Encephalomyelitis, Acute Disseminated	5%
328	Prognathism	5%
329	Dyskinesia, Drug-Induced	4.9%
330	Jaw Abnormalities	4.9%
331	Central Nervous System Cysts	4.9%
332	Goldenhar Syndrome	4.8%
333	Dystonia Musculorum Deformans	4.8%
334	Subdural Effusion	4.8%
335	Parkinsonian Disorders	4.8%
336	Nocturnal Myoclonus Syndrome	4.8%
337	Tuberculosis, Spinal	4.7%
338	Neoplasms, Radiation-Induced	4.7%
339	Rubinstein-Taybi Syndrome	4.7%
340	Congenital Hypothyroidism	4.7%
341	Eye Injuries	4.7%
342	Acromegaly	4.6%
343	Rheumatoid Vasculitis	4.6%
344	Uterine Rupture	4.6%
345	Gastroschisis	4.6%
346	Leukoencephalopathy, Progressive Multifocal	4.6%
347	Mandibulofacial Dysostosis	4.5%
348	Brain Neoplasms	4.5%
349	Multiple Sclerosis	4.5%
350	Spinal Cord Neoplasms	4.5%
351	Antley-Bixler Syndrome Phenotype	4.4%
352	Horner Syndrome	4.4%
353	Central Nervous System Infection	4.3%
354	Optic Neuropathy	4.3%
355	POEMS Syndrome	4.3%
356	Amyloid Neuropathies, Familial	4.3%
357	Microcephaly	4.3%
358	Macrocephaly	4.3%
359	Akathisia, Drug-Induced	4.3%
360	Chondrodysplasia Punctata	4.3%
361	Enchondromatosis	4.3%
362	Lordosis	4.3%
363	Osteosclerosis	4.3%
364	Spondylolysis	4.3%
365	kyphosis	4.3%
366	Kashin-Beck Disease	4.3%
367	Facial Nerve Diseases	4.2%
368	Parasomnia	4.2%
369	Dyssomnias	4.2%
370	Limbic Encephalitis	4.2%
371	Huntington Disease	4.2%
372	Vestibulocochlear Nerve Diseases	4.2%
373	Arthritis, Infectious	4.2%
374	Decerebrate State	4.2%
375	Hemiparesis	4.2%
376	Hydranencephaly	4.2%
377	Meningism	4.2%
378	Multiple Epiphyseal Dysplasia	4.2%
379	Neural Tube Defects	4.2%
380	Osteochondrodysplasias	4.2%
381	Paresis	4.2%
382	Seizures	4.2%
383	Sensation Disorders	4.2%
384	Tethered Cord Syndrome	4.2%
385	Central Nervous System Neoplasms	4.2%
386	Complex partial seizures	4.2%
387	Iniencephaly	4.2%
388	Craniorachischisis	4.2%
389	Exencephaly	4.2%
390	Monoparesis	4.2%
391	Septo-Optic Dysplasia	4.2%
392	Cortical Dysplasia	4.2%
393	Neurogenic Inflammation	4.2%
394	Gait Disorders, Neurologic	4.2%
395	Neuromuscular Manifestations	4.2%
396	Malformations of Cortical Development	4.2%
397	Sweating, Gustatory	4.1%
398	Auriculotemporal Syndrome	4.1%
399	Lupus Vasculitis, Central Nervous System	4.1%
400	Granuloma, Foreign-Body	4.1%
401	Osteomyelitis	4.1%
402	Osteoporosis	4.1%
403	Periostitis	4.1%
404	Bone Demineralization, Pathologic	4.1%
405	Post-Traumatic Osteoporosis	4.1%
406	Arthritis, Experimental	4.1%
407	Subarachnoid Hemorrhage, Traumatic	4.1%
408	Carotid Artery, Internal, Dissection	4.1%
409	Sicca Syndrome	4.1%
410	Sjogren's Syndrome	4.1%
411	Alveolar Bone Loss	4.1%
412	Amelia	4.1%
413	Arachnodactyly	4.1%
414	Ectromelia	4.1%
415	Femur Head Necrosis	4.1%
416	Hemimelia	4.1%
417	Phocomelia	4.1%
418	Sirenomelia	4.1%
419	Polydactyly	4.1%
420	Brachydactyly	4.1%
421	Plagiocephaly	4.1%
422	Lower Extremity Deformities, Congenital	4.1%
423	Upper Extremity Deformities, Congenital	4.1%
424	Osteolysis	4.1%
425	Uterine Perforation	4.1%
426	Meige Syndrome	4.1%
427	Cerebral Ventriculitis	4.1%
428	Scrapie	4%
429	Alstrom Syndrome	4%
430	Refsum Disease	4%
431	Cardiotoxicity	4%
432	Nail-Patella Syndrome	4%
433	Presenile dementia	4%
434	Senile dementia	4%
435	Meningitis, Bacterial	4%
436	Meningitis, Fungal	4%
437	Giant Cell Epulis	3.9%
438	Leukemia, Radiation-Induced	3.9%
439	Lafora Disease	3.9%
440	Unverricht-Lundborg Syndrome	3.9%
441	Chorea	3.9%
442	Brain Abscess	3.9%
443	Ophthalmoplegia	3.9%
444	External Ophthalmoplegia	3.9%
445	Radiation Pneumonitis	3.9%
446	Radiation Fibrosis	3.9%
447	Palatal Neoplasms	3.9%
448	Aortic Rupture	3.9%
449	Arthralgia	3.9%
450	Polyarthralgia	3.9%
451	Micrognathism	3.9%
452	Pierre Robin Syndrome	3.9%
453	Melorheostosis	3.8%
454	Osteopetrosis	3.8%
455	Spondylolisthesis	3.8%
456	Vasculitis, Central Nervous System	3.8%
457	Canavan Disease	3.8%
458	Alexander Disease	3.8%
459	Jet Lag Syndrome	3.8%
460	Porencephaly	3.8%
461	Neurofibrosarcoma	3.8%
462	Cerebellar Neoplasms	3.8%
463	Hematoma, Subdural	3.8%
464	Hematoma, Epidural, Cranial	3.8%
465	Tuberous Sclerosis	3.7%
466	Dementia, Vascular	3.7%
467	Posterior Leukoencephalopathy Syndrome	3.7%
468	Posterior reversible encephalopathy syndrome	3.7%
469	Ataxia Telangiectasia	3.6%
470	Dwarfism	3.6%
471	Pupil Disorders	3.6%
472	Neurobehavioral Manifestations	3.6%
473	Friedreich Ataxia	3.5%
474	Brain Death	3.5%
475	Paraneoplastic Encephalomyelitis	3.5%
476	Retrognathia	3.5%
477	Laryngomalacia	3.5%
478	Akinetic Mutism	3.4%
479	Anoxic Encephalopathy	3.4%
480	Arachnoiditis	3.4%
481	Basal Ganglia Diseases	3.4%
482	Brain Damage, Chronic	3.4%
483	Cerebellar Diseases	3.4%
484	Encephalitis	3.4%
485	Encephalomalacia	3.4%
486	Epilepsy	3.4%
487	Hydrocephalus	3.4%
488	Congenital Hydrocephalus	3.4%
489	Hypothalamic Diseases	3.4%
490	Aseptic Meningitis	3.4%
491	Syringomyelia	3.4%
492	Thalamic Diseases	3.4%
493	Uveomeningoencephalitic Syndrome	3.4%
494	Intracranial Hypertension	3.4%
495	Aura	3.4%
496	Leukoencephalopathy	3.4%
497	Essential Tremor	3.4%
498	Neuroaxonal Dystrophies	3.4%
499	Familial Tremor	3.4%
500	Headache Disorders	3.4%
501	Intracranial Hypotension	3.4%
502	Brain Edema	3.4%
503	Brain Hypoxia	3.4%
504	Aqueductal Stenosis	3.4%
505	Pneumorrhachis	3.4%
506	Writer's Cramp	3.4%
507	Vocal Cord Paralysis	3.4%
508	Sturge-Weber Syndrome	3.4%
509	Vertigo	3.4%
510	Alcohol-Induced Disorders, Nervous System	3.4%
511	Corneal Scar	3.4%
512	Amblyopia	3.4%
513	Abnormalities, Radiation-Induced	3.4%
514	Osteoporosis, Postmenopausal	3.4%
515	Eosinophilic Granuloma	3.4%
516	Joint Tuberculosis	3.4%
517	Tuberculosis, Osteoarticular	3.4%
518	Bone Tuberculosis	3.4%
519	Cockayne Syndrome	3.4%
520	Creutzfeldt-Jakob disease	3.4%
521	Basal Ganglia Cerebrovascular Disease	3.4%
522	Paraneoplastic Cerebellar Degeneration	3.4%
523	Radiation Injuries, Experimental	3.4%
524	Myoclonic Epilepsy	3.4%
525	Epilepsy, Temporal Lobe	3.4%
526	Holoprosencephaly	3.4%
527	Epilepsy, Rolandic	3.4%
528	Benign Rolandic Epilepsy	3.4%
529	Cerebellar Ataxia	3.3%
530	Supratentorial Neoplasms	3.3%
531	Torticollis	3.3%
532	Multiple Sclerosis, Chronic Progressive	3.3%
533	Multiple Sclerosis, Relapsing-Remitting	3.3%
534	Gait Ataxia	3.3%
535	Hematoma, Subdural, Intracranial	3.3%
536	Hematoma, Subdural, Chronic	3.3%
537	Hematoma, Subdural, Acute	3.3%
538	Tuberculosis, Meningeal	3.3%
539	Hepatolenticular Degeneration	3.2%
540	Corneal Perforation	3.1%
541	Vascular Headaches	3.1%
542	Hypoxia-Ischemia, Brain	3.1%
543	Tardive Dyskinesia	3.1%
544	Basal Cell Nevus Syndrome	3.1%
545	Persistent Vegetative State	3.1%
546	Alice in Wonderland Syndrome	3%
547	Juvenile Myoclonic Epilepsy	3%
548	Myoclonic Epilepsies, Progressive	3%
549	Voice Disorders	3%
550	Voice Disturbance	3%
551	Alcohol Withdrawal Seizures	3%
552	Smith-Magenis syndrome	2.9%
553	Maxillofacial Abnormalities	2.9%
554	Dural Arteriovenous Fistula	2.9%
555	Akathisia	2.9%
556	Restlessness	2.9%
557	Psychomotor Agitation	2.9%
558	Cleft Palate	2.9%
559	Rickets	2.9%
560	Leukomalacia, Periventricular	2.9%
561	Bronchomalacia	2.9%
562	Tracheomalacia	2.9%
563	Optic Nerve Glioma	2.9%
564	Pituitary Adenoma	2.9%
565	Pituitary Neoplasms	2.9%
566	Osteogenesis Imperfecta	2.9%
567	Shoulder Pain	2.9%
568	Toxoplasmosis, Cerebral	2.8%
569	Mastoiditis	2.8%
570	Petrositis	2.8%
571	Brain Diseases, Metabolic	2.8%
572	Cerebrovascular Disorders	2.8%
573	Optic Atrophy	2.8%
574	Optic Neuritis	2.8%
575	Papilledema	2.8%
576	Strabismus	2.8%
577	Tolosa-Hunt Syndrome	2.8%
578	Cerebrovascular Insufficiency	2.8%
579	Arsenic Poisoning	2.8%
580	Dementia	2.8%
581	Central Nervous System Fungal Infections	2.8%
582	Spinal Cord Vascular Diseases	2.8%
583	Brain Stem Neoplasms	2.8%
584	Facial Neuralgia	2.7%
585	Sleep Talking	2.7%
586	Manganese Poisoning	2.7%
587	Sleep Disorders, Intrinsic	2.7%
588	Orthostatic intolerance	2.7%
589	Anosmia	2.7%
590	Ataxia	2.7%
591	Athetosis	2.7%
592	Catalepsy	2.7%
593	Dystonia	2.7%
594	Hemiplegia	2.7%
595	Locked-In Syndrome	2.7%
596	Meningeal Neoplasms	2.7%
597	Meningomyelocele	2.7%
598	Muscle Hypertonia	2.7%
599	Muscle hypotonia	2.7%
600	Myoclonus	2.7%
601	Myotonia	2.7%
602	Paraplegia	2.7%
603	Pseudobulbar Palsy	2.7%
604	Quadriplegia	2.7%
605	Spasm	2.7%
606	Spastic Paraplegia	2.7%
607	Status Epilepticus	2.7%
608	Taste Disorders	2.7%
609	Tremor	2.7%
610	Spina Bifida	2.7%
611	Monoplegia	2.7%
612	Hypokinesia	2.7%
613	Paraparesis	2.7%
614	Bradykinesia	2.7%
615	Waxy flexibility	2.7%
616	Action Tremor	2.7%
617	Resting Tremor	2.7%
618	Dysosmia	2.7%
619	Quadriparesis	2.7%
620	Mercury Poisoning, Nervous System	2.7%
621	Olfaction Disorders	2.7%
622	Myokymia	2.7%
623	Lead Poisoning, Nervous System	2.7%
624	Vestibular Neuronitis	2.7%
625	Somatosensory Disorders	2.7%
626	Hyperkinesia	2.7%
627	Intention tremor	2.7%
628	Amnesia, Transient Global	2.7%
629	Gait Apraxia	2.7%
630	Basal Ganglia Hemorrhage	2.6%
631	Meningitis, Cryptococcal	2.6%
632	Meningitis, Listeria	2.6%
633	Meningitis, Haemophilus	2.6%
634	Meningitis, Pneumococcal	2.6%
635	Frontotemporal dementia	2.6%
636	Cerebral Palsy	2.6%
637	Epilepsies, Partial	2.6%
638	Epilepsy, Generalized	2.6%
639	Pseudotumor Cerebri	2.6%
640	Hypertensive Encephalopathy	2.6%
641	Simple Partial Seizures	2.6%
642	Epilepsy, Reflex	2.6%
643	Postural Orthostatic Tachycardia Syndrome	2.6%
644	Headache Disorders, Primary	2.6%
645	Headache Disorders, Secondary	2.6%
646	Medication overuse headache	2.6%
647	Reflex, Abnormal	2.5%
648	Hyporeflexia	2.5%
649	Hyperreflexia	2.5%
650	Pseudohypoparathyroidism	2.5%
651	Choroid Plexus Papilloma	2.5%
652	Subacute Sclerosing Panencephalitis	2.4%
653	Pituitary Apoplexy	2.4%
654	Putaminal Hemorrhage	2.4%
655	Osteomalacia	2.4%
656	Brain Infarction	2.4%
657	Adrenoleukodystrophy	2.4%
658	Infarction, Middle Cerebral Artery	2.4%
659	Infarction, Anterior Cerebral Artery	2.4%
660	Infarction, Posterior Cerebral Artery	2.4%
661	Vision Disorders	2.3%
662	Metamorphopsia	2.3%
663	Visual Impairment	2.3%
664	Optic Neuropathy, Ischemic	2.3%
665	Anterior Ischemic Optic Neuropathy	2.3%
666	Central Nervous System Bacterial Infections	2.3%
667	Facial Hemiatrophy	2.3%
668	Melkersson-Rosenthal Syndrome	2.3%
669	Anisocoria	2.3%
670	Confusion	2.3%
671	Facial paralysis	2.3%
672	Lethargy	2.3%
673	Memory Disorders	2.3%
674	Perceptual Disorders	2.3%
675	Psychomotor Disorders	2.3%
676	Tonic Pupil	2.3%
677	Anhedonia	2.3%
678	Disorientation	2.3%
679	Facial Paresis	2.3%
680	Memory Loss	2.3%
681	Hemisensory Neglect	2.3%
682	Dysacusis	2.3%
683	Sleep Bruxism	2.3%
684	Classical Lissencephalies and Subcortical Band Heterotopias	2.3%
685	Anencephaly	2.3%
686	Meningocele	2.3%
687	Muscular Atrophy	2.3%
688	Respiratory Paralysis	2.3%
689	Encephalocele	2.3%
690	Noonan Syndrome	2.3%
691	Tetany	2.2%
692	Auditory Perceptual Disorders	2.2%
693	Acoustic Neuroma	2.2%
694	Giant Cell Arteritis	2.2%
695	Temporal Arteritis	2.2%
696	Pituitary Diseases	2.1%
697	Post-Traumatic Headache	2.1%
698	Tension Headache	2.1%
699	Epilepsy, Complex Partial	2.1%
700	Migraine Disorders	2.1%
701	Abdominal Migraine	2.1%
702	Status Migrainosus	2.1%
703	Cervicogenic Headache	2.1%
704	Cerebral Infarction	2.1%
705	Brain Stem Infarctions	2.1%
706	Alexia	2.1%
707	Dyslexia	2.1%
708	Marfan Syndrome	2%
709	Carotid Artery Diseases	2%
710	Brain Ischemia	2%
711	Esotropia	2%
712	Exotropia	2%
713	Hypotension, Orthostatic	2%
714	Sleep Apnea Syndromes	2%
715	Cerebrovascular accident	2%
716	Kluver-Bucy Syndrome	2%
717	Vasospasm, Intracranial	2%
718	Spinal Cord Ischemia	2%
719	Intracranial Arterial Diseases	2%
720	Post-Exercise Hypotension	2%
721	Disorders of Excessive Somnolence	2%
722	Sleep Initiation and Maintenance Disorders	2%
723	Night Terrors	2%
724	Somnambulism	2%
725	Trigeminal Nerve Disorder	2%
726	Transient Insomnia	2%
727	Sleep Paralysis	2%
728	Chronic Insomnia	2%
729	REM Sleep Behavior Disorder	2%
730	Hypersomnia	2%
731	Dermal Sinus	2%
732	Dysgeusia	2%
733	Formication	2%
734	Hyperalgesia	2%
735	Hyperesthesia	2%
736	Hypesthesia	2%
737	Language Disorders	2%
738	Numbness	2%
739	Paresthesia	2%
740	Paraparesis, Spastic	2%
741	Spina Bifida Cystica	2%
742	Trismus	2%
743	Spina Bifida Occulta	2%
744	Epilepsia Partialis Continua	2%
745	Hypogeusia	2%
746	Meningeal Carcinomatosis	2%
747	Brown-Sequard Syndrome	2%
748	Lissencephaly	2%
749	Polymicrogyria	2%
750	Pachygyria	2%
751	Schizencephaly	2%
752	Lockjaw	2%
753	Allodynia	2%
754	Lead Poisoning, Nervous System, Childhood	2%
755	Lead Poisoning, Nervous System, Adult	2%
756	Periventricular Nodular Heterotopia	2%
757	Ageusia	2%
758	Tuberculosis, Central Nervous System	2%
759	Lateral Medullary Syndrome	2%
760	West Nile Fever	2%
761	Duane Retraction Syndrome	2%
762	Consciousness Disorders	2%
763	Mental Retardation	2%
764	Depressed Level of Consciousness	2%
765	Mental deficiency	2%
766	Intellectual Disability	2%
767	Moyamoya Disease	2%
768	Mobius Syndrome	2%
769	Bell Palsy	2%
770	Catatonia	2%
771	Herpes Zoster Oticus	1.9%
772	Aphonia	1.9%
773	Sleep Deprivation	1.9%
774	Dysphonia	1.9%
775	Cluster Headache	1.9%
776	Migraine with Aura	1.9%
777	Familial Hemiplegic Migraine	1.9%
778	Chronic Paroxysmal Hemicrania	1.9%
779	SUNCT Syndrome	1.9%
780	Paroxysmal Hemicrania	1.9%
781	Radicular Cyst	1.9%
782	Optic Atrophy, Hereditary, Leber	1.8%
783	Empty Sella Syndrome	1.7%
784	Hyperpituitarism	1.7%
785	Hypopituitarism	1.7%
786	Nose Neoplasms	1.7%
787	Hypophysitis	1.7%
788	Congenital nystagmus	1.7%
789	Diplopia	1.7%
790	Scotoma	1.7%
791	Photophobia	1.7%
792	Hemifacial Spasm	1.7%
793	Amaurosis	1.7%
794	Blindness	1.7%
795	Reye Syndrome	1.7%
796	Neuroaspergillosis	1.7%
797	Intracranial Embolism and Thrombosis	1.7%
798	Hepatic Encephalopathy	1.7%
799	Cerebral Arterial Diseases	1.7%
800	Vertebrobasilar Insufficiency	1.7%
801	Anterior Spinal Artery Syndrome	1.7%
802	Basilar Artery Stenosis	1.7%
803	Vertebral Artery Stenosis	1.7%
804	Sleep Apnea, Obstructive	1.7%
805	Sleep Apnea, Central	1.7%
806	Intracranial Hemorrhage, Hypertensive	1.7%
807	Transient Cerebral Ischemia	1.7%
808	Agnosia	1.7%
809	Apraxias	1.7%
810	Hallucinations	1.7%
811	Hemianopsia	1.7%
812	Hyperacusis	1.7%
813	Tinnitus	1.7%
814	Visual Agnosia	1.7%
815	Anosognosia	1.7%
816	Wernicke-Korsakoff Syndrome	1.7%
817	Phonophobia	1.7%
818	Hearing Loss	1.7%
819	Narcolepsy	1.7%
820	Trigeminal Neuralgia	1.7%
821	Kleine-Levin Syndrome	1.7%
822	Agraphia	1.7%
823	Anomia	1.7%
824	Cluttering	1.7%
825	Language Development Disorders	1.7%
826	Speech Disorders	1.7%
827	Syncope	1.7%
828	Stupor	1.7%
829	Dysgraphia	1.7%
830	Presyncope	1.7%
831	Dyslalia	1.7%
832	Sarcopenia	1.7%
833	Neuronal Ceroid-Lipofuscinoses	1.7%
834	Renal Osteodystrophy	1.7%
835	Renal rickets	1.7%
836	Hyperprolactinemia	1.5%
837	Aicardi's syndrome	1.5%
838	Hoarseness	1.5%
839	Pseudorabies	1.5%
840	Subclavian Steal Syndrome	1.5%
841	Pick Disease of the Brain	1.5%
842	Cataplexy	1.5%
843	Aphasia	1.5%
844	Articulation Disorders	1.5%
845	Echolalia	1.5%
846	Stuttering	1.5%
847	Dysphasia	1.5%
848	Alcohol Withdrawal Delirium	1.5%
849	Amnesia	1.5%
850	Delirium	1.5%
851	Dissociative Amnesia	1.5%
852	Color blindness	1.5%
853	Global Amnesia	1.5%
854	Cri-du-Chat Syndrome	1.4%
855	Down Syndrome	1.4%
856	Brain Diseases, Metabolic, Inborn	1.4%
857	Trisomy 21	1.4%
858	Meningioma	1.4%
859	Williams Syndrome	1.4%
860	Neurosyphilis	1.4%
861	Dysarthria	1.4%
862	Toxoplasmosis, Congenital	1.4%
863	Malaria, Cerebral	1.4%
864	Carotid Stenosis	1.4%
865	Intracranial Aneurysm	1.4%
866	Neurocysticercosis	1.4%
867	Amaurosis Fugax	1.4%
868	Blindness, Cortical	1.4%
869	Dyscalculia	1.4%
870	Intracranial Arteriosclerosis	1.4%
871	Cerebral Atherosclerosis	1.4%
872	Rett Syndrome	1.4%
873	Subarachnoid Hemorrhage	1.4%
874	Cerebral Arteriosclerosis	1.4%
875	Cerebral Hemorrhage	1.4%
876	Cerebral Thrombosis	1.4%
877	Intracranial Embolism	1.4%
878	Intracranial Thrombosis	1.4%
879	Deafness	1.4%
880	Hearing Loss, Sudden	1.4%
881	Gerstmann Syndrome	1.4%
882	Hearing Loss, Bilateral	1.4%
883	Hearing Loss, High-Frequency	1.4%
884	Hearing Loss, Mixed Conductive-Sensorineural	1.4%
885	Prosopagnosia	1.4%
886	Apraxia, Ideomotor	1.4%
887	Charles Bonnet Syndrome	1.4%
888	Hearing Loss, Unilateral	1.4%
889	Complete Hearing Loss	1.4%
890	Alien Hand Syndrome	1.4%
891	Deaf Mutism	1.4%
892	Waterhouse-Friderichsen Syndrome	1.3%
893	Mutism	1.3%
894	Selective Mutism	1.3%
895	Menkes Kinky Hair Syndrome	1.3%
896	Prader-Willi Syndrome	1.3%
897	Wernicke Encephalopathy	1.3%
898	AIDS Dementia Complex	1.3%
899	Cerebral Amyloid Angiopathy	1.2%
900	Phantom pain	1.2%
901	Phantom Limb Pain	1.2%
902	Sinus Thrombosis, Intracranial	1.2%
903	Lyme Neuroborreliosis	1.2%
904	Retrograde amnesia	1.2%
905	Amnesia, Anterograde	1.2%
906	Carotid Artery Thrombosis	1.2%
907	Alexia, Pure	1.2%
908	Cavernous Sinus Thrombosis	1.2%
909	Sagittal Sinus Thrombosis	1.2%
910	Kernicterus	1.1%
911	Fragile X Syndrome	1%
912	Nelson Syndrome	1%
913	Fabry Disease	1%
914	Familial Hypophosphatemic Rickets	1%
915	Prolactinoma	0.9%
916	Growth Hormone-Secreting Pituitary Adenoma	0.9%
917	Galactosemias	0.9%
918	Urea Cycle Disorders, Inborn	0.9%
919	Tyrosinemias	0.9%
920	Homocystinuria	0.8%
921	Leigh Disease	0.8%
922	Mucopolysaccharidosis II	0.7%
923	Carbamoyl-Phosphate Synthase I Deficiency Disease	0.7%
924	Glycogen storage disease type II	0.7%
925	Zellweger Syndrome	0.6%
926	Gaucher Disease	0.6%
927	Tay-Sachs Disease	0.5%
928	Niemann-Pick Disease, Type C	0.5%

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