MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Anemia, Pernicious

(UMLS:C0002892)

Definition:: A megaloblastic anemia occurring in children but more commonly in later life, characterized by histamine-fast achlorhydria, in which the laboratory and clinical manifestations are based on malabsorption of vitamin B 12 due to a failure of the gastric mucosa to secrete adequate and potent intrinsic factor. (Dorland, 27th ed)
UMLS ID:: C0002892
MeSH ID:: D000752

Classification 1:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.071.252.196.500

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.654.521.500.133.699.923.280

Synonym(s)

Anemia, Pernicious

ANEMIA PERNICIOUS

ANEMIA, ADDISONIAN PERNICIOUS

ANEMIA, BIERMER

Addison's anaemia

Addison's anemia

Addison; anemia

Addisonian pernicious anaemia

Addisonian pernicious anemia

10.

Anaemia;pernicious

11.

Biermer's anaemia

12.

Biermer's anemia

13.

Biermer; anemia

14.

Intrinsic Factor Deficiency

15.

Megaloblastic anaemia due to impaired absorption of cobalamin

16.

Megaloblastic anemia due to impaired absorption of cobalamin

17.

PA - Pernicious anaemia

18.

PA - Pernicious anemia

19.

PERNICIOUS ANEMIA

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Hydroxocobalamin	17098697	CTD
2	Prednisolone	17098697	CTD
3	Pyridostigmine Bromide	17098697	CTD
4	Vitamin B 12	View details 857850 5572387 6533326 9314271 11360403 13082065	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Folic Acid Deficiency	24.8%
2	Pellagra	24.8%
3	Thiamine Deficiency	24.8%
4	Vitamin B 6 Deficiency	24.8%
5	Pyridoxine Deficiency	24.8%
6	Vitamin K Deficiency	22.2%
7	Ascorbic Acid Deficiency	20.4%
8	Vitamin A Deficiency	20.4%
9	Vitamin D Deficiency	20.4%
10	Vitamin E Deficiency	20.4%
11	Anemia, Hemolytic	18.7%
12	Magnesium Deficiency	17.9%
13	Potassium Deficiency	17.9%
14	Protein Deficiency	17.9%
15	Beriberi	16.5%
16	Starvation	15.9%
17	Refeeding Syndrome	15.9%
18	Subacute Combined Degeneration	15%
19	Blood Coagulation Disorders	14.8%
20	Blood Platelet Disorders	14.8%
21	Bone Marrow Diseases	14.8%
22	Hemorrhagic Disorders	14.8%
23	Leukocyte Disorders	14.8%
24	Methemoglobinemia	14.8%
25	Pancytopenia	14.8%
26	Polycythemia	14.8%
27	Sulfhemoglobinemia	14.8%
28	Thrombophilia	14.8%
29	Erythrocytosis	14.8%
30	Disseminated Intravascular Coagulation	14.7%
31	Protein S Deficiency	14.7%
32	Anemia, Neonatal	14.4%
33	Hyperhomocysteinemia	14.4%
34	Wasting Syndrome	13.8%
35	Child Nutrition Disorders	13.5%
36	Hypervitaminosis A	13.5%
37	Infant Nutrition Disorders	13.5%
38	Thrombocythemia, Essential	12.1%
39	Hemoglobinuria, Paroxysmal	12%
40	Transfusion Reaction	11.7%
41	Hypotensive Transfusion Reaction	11.7%
42	Pregnancy Complications, Hematologic	11.3%
43	Hematologic Neoplasms	11.3%
44	Anemia, Diamond-Blackfan	10.9%
45	Thrombasthenia	10.6%
46	Antithrombin III Deficiency	10.6%
47	Protein C Deficiency	10.6%
48	Scurvy	10.3%
49	Marasmus	9.9%
50	Bone Marrow Neoplasms	9.8%
51	Lymphatic Diseases	9.7%
52	Thrombocytosis	9.6%
53	Metabolic Diseases	9.3%
54	Afibrinogenemia	8.9%
55	Factor VII Deficiency	8.9%
56	Factor X Deficiency	8.9%
57	Factor XII Deficiency	8.9%
58	Hemophilia A	8.9%
59	Activated Protein C Resistance	8.9%
60	Factor II deficiency	8.9%
61	Factor VIII Deficiency	8.9%
62	Factor V deficiency	8.9%
63	Factor XI Deficiency	8.9%
64	Hypoprothrombinemias	8.9%
65	Rickets	8.6%
66	Kwashiorkor	8.3%
67	Wernicke Encephalopathy	8.3%
68	Eosinophilia	8%
69	Hypoproteinemia	8%
70	Leukopenia	8%
71	Thrombocytopenia	8%
72	Leukostasis	8%
73	MYELODYSPLASTIC SYNDROME	8%
74	Anemia, Sickle Cell	7.8%
75	Thalassemia	7.8%
76	Polycythemia Vera	7.2%
77	Leukemoid Reaction	7.2%
78	Hemolytic-Uremic Syndrome	7.2%
79	Agammaglobulinemia	6.6%
80	Fanconi Anemia	6.5%
81	Leukocytosis	6.2%
82	Paraproteinemias	6.2%
83	Pelger-Huet Anomaly	6.2%
84	Pleocytosis	6.2%
85	Wiskott-Aldrich Syndrome	6.1%
86	Purpura, Thrombotic Thrombocytopenic	5.8%
87	Infectious Mononucleosis	5.4%
88	Osteomalacia	5.3%
89	Sickle Cell Trait	5.2%
90	Hypergammaglobulinemia	5%
91	Adenitis	4.9%
92	Histiocytosis	4.9%
93	Lymphadenitis	4.9%
94	Lymphangitis	4.9%
95	Lymphedema	4.9%
96	Splenic Diseases	4.9%
97	Thymus Hyperplasia	4.9%
98	Pseudolymphoma	4.9%
99	Lymphadenopathy	4.9%
100	Transfusion-Related Acute Lung Injury	4.9%
101	Ecchymosis	4.9%
102	Petechiae	4.9%
103	Purpura	4.9%
104	Atypical Hemolytic Uremic Syndrome	4.9%
105	Cryoglobulinemia	4.9%
106	Monoclonal Gammopathy of Undetermined Significance	4.9%
107	Primary Myelofibrosis	4.8%
108	Agranulocytosis	4.8%
109	Lymphocytosis	4.8%
110	Myelofibrosis	4.8%
111	Myeloid Metaplasia	4.8%
112	Hypoalbuminemia	4.8%
113	Hypereosinophilic syndrome	4.8%
114	bone marrow fibrosis	4.8%
115	Thrombotic Microangiopathies	4.8%
116	Waldenstrom Macroglobulinemia	4.7%
117	Autoimmune thrombocytopenia	4.6%
118	Immune thrombocytopenic purpura	4.6%
119	Heavy Chain Disease	4.5%
120	Acid-Base Imbalance	4.5%
121	Calcium Metabolism Disorders	4.5%
122	Iron Metabolism Disorders	4.5%
123	Phosphorus Metabolism Disorders	4.5%
124	Water-Electrolyte Imbalance	4.5%
125	Lipid Metabolism Disorders	4.5%
126	Mitochondrial Diseases	4.5%
127	Glucose Metabolism Disorders	4.5%
128	Purpura, Hyperglobulinemic	4.1%
129	Acute Chest Syndrome	4%
130	Kernicterus	4%
131	HIV Wasting Syndrome	3.9%
132	Hydrops Fetalis	3.8%
133	Lymphocele	3.8%
134	Lymphoproliferative Disorders	3.8%
135	Lymphatic Abnormalities	3.8%
136	Thymus Neoplasms	3.7%
137	Lymphopenia	3.7%
138	Multiple Myeloma	3.7%
139	Job Syndrome	3.6%
140	Leukemia, Myelomonocytic, Chronic	3.6%
141	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	3.6%
142	Renal Osteodystrophy	3.6%
143	Renal rickets	3.6%
144	Thrombocytopenic purpura	3.5%
145	Waterhouse-Friderichsen Syndrome	3.5%
146	Osteopenia	3.5%
147	Hypercalcemia	3.4%
148	Hypocalcemia	3.4%
149	Milk-Alkali Syndrome	3.4%
150	Brain Diseases, Metabolic	3.4%
151	Obesity	3.4%
152	Lymphangiectasis, Intestinal	3.3%
153	Neutropenia	3.2%
154	Mucocutaneous Lymph Node Syndrome	3%
155	Eosinophilia-Myalgia Syndrome	3%
156	Chronic granulomatous disease	2.9%
157	Shwartzman Phenomenon	2.9%
158	Hemangioma, Cavernous	2.9%
159	Purpura Fulminans	2.9%
160	Eosinophilic Granuloma	2.8%
161	Lipodystrophy	2.8%
162	Elephantiasis	2.7%
163	Hypersplenism	2.7%
164	Sarcoidosis	2.7%
165	Elephantiasis Nostras Verrucosa	2.7%
166	Pseudohypoparathyroidism	2.5%
167	Pulmonary Eosinophilia	2.4%
168	Eosinophilic Pneumonia	2.4%
169	POEMS Syndrome	2.4%
170	Leukemia, Myeloid, Chronic-Phase	2.4%
171	Febrile Neutropenia	2.4%
172	Brain Diseases, Metabolic, Inborn	2.3%
173	Acidosis	2.3%
174	Alkalosis	2.3%
175	Amyloidosis	2.3%
176	Calcinosis	2.3%
177	Hyperglycemia	2.3%
178	Hyperinsulinism	2.3%
179	Hyperkalemia	2.3%
180	Hypernatremia	2.3%
181	Hypoglycemia	2.3%
182	Hypokalemia	2.3%
183	Hyponatremia	2.3%
184	Xanthomatosis	2.3%
185	Hypophosphatemia	2.3%
186	Metabolic acidosis	2.3%
187	Dyslipidemias	2.3%
188	Iron Overload	2.3%
189	Xanthoma	2.3%
190	Familial Hypophosphatemic Rickets	2.2%
191	Obesity, Abdominal	2.1%
192	Granuloma	2.1%
193	Histiocytic Disorders, Malignant	2.1%
194	Splenic Infarction	2.1%
195	Splenic Neoplasms	2.1%
196	Histiocytosis, Langerhans-Cell	2%
197	Tumor Lysis Syndrome	2%
198	Diabetes Mellitus	1.8%
199	Leigh Disease	1.8%
200	Pediatric Obesity	1.8%
201	Dehydration	1.8%
202	Lipomatosis	1.8%
203	Water Intoxication	1.8%
204	Werner Syndrome	1.8%
205	Lactose Intolerance	1.7%
206	Achlorhydria	1.7%
207	Amino Acid Metabolism, Inborn Errors	1.7%
208	Bloom Syndrome	1.7%
209	Carbohydrate Metabolism, Inborn Errors	1.7%
210	Metal Metabolism, Inborn Errors	1.7%
211	Osteoporosis	1.7%
212	Progeria	1.7%
213	Lysosomal Storage Diseases	1.7%
214	Bone Demineralization, Pathologic	1.7%
215	Cytochrome-c Oxidase Deficiency	1.7%
216	Peroxisomal Disorders	1.7%
217	Post-Traumatic Osteoporosis	1.7%
218	Celiac Disease	1.7%
219	Sprue, Tropical	1.7%
220	Steatorrhea	1.7%
221	Sprue	1.7%
222	Splenic Rupture	1.7%
223	Pseudoxanthoma Elasticum	1.7%
224	Lymphoma	1.7%
225	Thymoma	1.6%
226	Lymphohistiocytosis, Hemophagocytic	1.6%
227	Erdheim-Chester Disease	1.6%
228	Prader-Willi Syndrome	1.6%
229	Mitochondrial Encephalomyopathies	1.5%
230	Hypolipoproteinemias	1.4%
231	Sezary Syndrome	1.4%
232	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.4%
233	Mitochondrial Myopathies	1.4%
234	Myelinolysis, Central Pontine	1.4%
235	Autoimmune Lymphoproliferative Syndrome	1.4%
236	Glycosuria	1.4%
237	Reye Syndrome	1.4%
238	Hepatic Encephalopathy	1.4%
239	Smith-Lemli-Opitz Syndrome	1.4%
240	Galactosemias	1.4%
241	Urea Cycle Disorders, Inborn	1.4%
242	Tyrosinemias	1.4%
243	Congenital Hyperinsulinism	1.2%
244	Malignant histiocytosis	1.2%
245	Sarcoidosis, Pulmonary	1.2%
246	Histiocytic sarcoma	1.2%
247	Hyperphosphaturia	1.2%
248	Acidosis, Lactic	1.2%
249	Calciphylaxis	1.2%
250	Hemosiderosis	1.2%
251	Ketosis	1.2%
252	Ketonuria	1.2%
253	Ketoacidosis	1.2%
254	Ketonemia	1.2%
255	Vascular calcification	1.2%
256	Porphyrias, Hepatic	1.2%
257	Necrobiosis Lipoidica Diabeticorum	1.2%
258	Diabetic Ketoacidosis	1.1%
259	Hyperlipidemia, Familial Combined	1.1%
260	Homocystinuria	1%
261	Renal tubular acidosis	1%
262	Hyperlipoproteinemia Type IV	1%
263	Hyperlipoproteinemia Type V	1%
264	Friedreich Ataxia	1%
265	Splenosis	1%
266	Hodgkin Disease	1%
267	Lymphoma, Non-Hodgkin	1%
268	Leukemia, T-Cell	1%
269	Leukemia, B-Cell	1%
270	Hyperlipoproteinemia Type III	1%
271	Zellweger Syndrome	0.9%
272	Acidosis, Respiratory	0.9%
273	Adiposis Dolorosa	0.9%
274	Alkalosis, Respiratory	0.9%
275	HIV-Associated Lipodystrophy Syndrome	0.9%
276	Menkes Kinky Hair Syndrome	0.9%
277	Alkaptonuria	0.9%
278	Glycogen Storage Disease	0.9%
279	Hypophosphatasia	0.9%
280	Insulin Resistance	0.9%
281	Osteoporosis, Postmenopausal	0.9%
282	Propionic acidemia	0.9%
283	Dihydropyrimidine Dehydrogenase Deficiency	0.9%
284	Cystinosis	0.9%
285	Cockayne Syndrome	0.9%
286	Amyloid Neuropathies, Familial	0.9%
287	Hepatolenticular Degeneration	0.8%
288	MELAS Syndrome	0.8%
289	Refsum Disease	0.8%
290	Adrenoleukodystrophy	0.8%
291	Composite Lymphoma	0.8%
292	Neuronal Ceroid-Lipofuscinoses	0.8%
293	Lymphangioleiomyomatosis	0.8%
294	Glycosuria, Renal	0.8%
295	Glycogen storage disease type II	0.8%
296	Hypoalphalipoproteinemias	0.8%
297	Ataxia Telangiectasia	0.8%
298	Optic Atrophy, Hereditary, Leber	0.8%
299	Gestational Diabetes	0.7%
300	Latent Autoimmune Diabetes in Adults	0.7%
301	Diabetes Mellitus, Experimental	0.7%
302	Kearns-Sayre syndrome	0.7%
303	Nephrocalcinosis	0.7%
304	Tetany	0.7%
305	Cerebral Amyloid Angiopathy	0.7%
306	Xeroderma Pigmentosum	0.7%
307	Nesidioblastosis	0.7%
308	Hypercholesterolemia	0.7%
309	Hyperlipoproteinemias	0.7%
310	Hypertriglyceridemia	0.7%
311	Lymphoma, Follicular	0.6%
312	T-Cell Lymphoma	0.6%
313	Mantle cell lymphoma	0.6%
314	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	0.6%
315	Leukemia, Large Granular Lymphocytic	0.6%
316	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	0.6%
317	Niemann-Pick Disease, Type C	0.6%
318	Familial Periodic Paralysis	0.6%
319	Primary amyloidosis	0.6%
320	Gaucher Disease	0.6%
321	Variegate Porphyria	0.6%
322	Acute intermittent porphyria	0.6%
323	Porphyria Cutanea Tarda	0.6%
324	Renal Aminoacidurias	0.6%
325	Fanconi Syndrome	0.6%
326	Pseudohypoaldosteronism	0.6%
327	Liddle Syndrome	0.6%
328	Mucopolysaccharidosis III	0.6%
329	Gout	0.5%
330	Amyotrophic Lateral Sclerosis	0.5%
331	Antley-Bixler Syndrome Phenotype	0.5%
332	Sjogren-Larsson Syndrome	0.5%
333	Glycogen Storage Disease Type I	0.5%
334	Glycogen Storage Disease Type V	0.5%
335	Fabry Disease	0.5%
336	Lymphoma, T-Cell, Cutaneous	0.5%
337	Lymphoma, AIDS-Related	0.5%
338	Enteropathy-Associated T-Cell Lymphoma	0.5%
339	Primary Effusion Lymphoma	0.5%
340	CREST Syndrome	0.5%
341	Albinism	0.4%
342	Lymphomatoid Granulomatosis	0.4%
343	Canavan Disease	0.4%
344	Alexander Disease	0.4%
345	Mucopolysaccharidosis II	0.4%
346	Mycosis Fungoides	0.4%
347	Lymphomatoid Papulosis	0.4%
348	Plasmablastic lymphoma	0.4%
349	Burkitt Lymphoma	0.3%
350	Hypokalemic periodic paralysis	0.3%
351	Ichthyosis, X-Linked	0.3%
352	Frontotemporal dementia	0.3%
353	Cystinuria	0.3%
354	Arthritis, Gouty	0.3%
355	Tay-Sachs Disease	0.3%

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