MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Gaucher Disease

(UMLS:C0017205)

Definition:: An autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (GLUCOSYLCERAMIDASE) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the MONONUCLEAR PHAGOCYTE SYSTEM. The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. There are several subtypes based on the presence and severity of neurological involvement.
UMLS ID:: C0017205
MeSH ID:: D005776

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.163.100.435.825.400

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.565.189.435.825.400|C16.320.565.398.641.803.441|C16.320.565.595.554.825.400

Classification 3:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.132.100.435.825.400|C18.452.584.687.803.441|C18.452.648.189.435.825.400|C18.452.648.398.641.803.441|C18.452.648.595.554.825.400

Synonym(s)

Gaucher Disease

ANEMIA, SPLENIC, FAMILIAL

Adult Gaucher disease

CEREBROSIDE LIPOIDOSIS

CEREBROSIDE LIPOIDOSIS GAUCHERS ADULT FORM

Cerebroside lipidosis syndrome

Chronic adult Gaucher's disease

Chronic non-neuropathic Gaucher disease

Chronic non-neuropathic Gaucher's disease

10.

GLUCOSYL CEREBROSIDE LIPIDOSIS

11.

Gaucher disease

12.

Gaucher disease type I

13.

Gaucher splenomegaly

14.

Gaucher syndrome

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Warfarin	12359135	CTD
2	conduritol epoxide	19576930	CTD
3	miglustat	19299496 19959168	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Fabry Disease	56.8%
2	Glycogen storage disease type II	44.4%
3	Niemann-Pick Disease, Type C	43.7%
4	Galactosemias	41.4%
5	Urea Cycle Disorders, Inborn	41.4%
6	Tyrosinemias	41.4%
7	Leigh Disease	40.9%
8	Adrenoleukodystrophy	39.1%
9	Tay-Sachs Disease	38.4%
10	Hepatolenticular Degeneration	37.4%
11	Smith-Lemli-Opitz Syndrome	36.9%
12	Menkes Kinky Hair Syndrome	36.7%
13	Homocystinuria	34.2%
14	Zellweger Syndrome	34.2%
15	Refsum Disease	34.2%
16	Amino Acid Metabolism, Inborn Errors	31.5%
17	Carbohydrate Metabolism, Inborn Errors	31.5%
18	Metal Metabolism, Inborn Errors	31.5%
19	Progeria	31.5%
20	Peroxisomal Disorders	31.5%
21	Carbamoyl-Phosphate Synthase I Deficiency Disease	30.2%
22	Neuronal Ceroid-Lipofuscinoses	30.2%
23	Pseudohypoparathyroidism	29.6%
24	Hypolipoproteinemias	28.1%
25	Hyperphosphaturia	28%
26	MELAS Syndrome	26.8%
27	Brain Diseases, Metabolic, Inborn	25.8%
28	Hyperlipidemia, Familial Combined	25.5%
29	Wasting Syndrome	25.2%
30	Hyperlipoproteinemia Type IV	25.1%
31	Hyperlipoproteinemia Type V	25.1%
32	Sjogren-Larsson Syndrome	25.1%
33	Hyperlipoproteinemia Type III	24.3%
34	Hyperhomocysteinemia	23.9%
35	Cytochrome-c Oxidase Deficiency	23.7%
36	Lactose Intolerance	23.3%
37	Cystinosis	23.2%
38	Lysosomal Storage Diseases	22.4%
39	Amyloid Neuropathies, Familial	21.6%
40	Werner Syndrome	21.2%
41	Lipodystrophy	21%
42	Canavan Disease	20.7%
43	Alexander Disease	20.7%
44	Acid-Base Imbalance	20.6%
45	Calcium Metabolism Disorders	20.6%
46	Iron Metabolism Disorders	20.6%
47	Phosphorus Metabolism Disorders	20.6%
48	Water-Electrolyte Imbalance	20.6%
49	Mitochondrial Diseases	20.6%
50	Glucose Metabolism Disorders	20.6%
51	Albinism	20.4%
52	Mucopolysaccharidosis II	20.3%
53	Hypercalcemia	20%
54	Hypocalcemia	20%
55	Milk-Alkali Syndrome	20%
56	Ichthyosis, X-Linked	19.9%
57	Mucopolysaccharidosis III	19.3%
58	Osteopenia	18.9%
59	Familial Hypophosphatemic Rickets	18.6%
60	Mitochondrial Encephalomyopathies	18.5%
61	Renal tubular acidosis	18.2%
62	Cockayne Syndrome	18%
63	Rickets	17.6%
64	Alkaptonuria	17.5%
65	Glycogen Storage Disease	17.5%
66	Hypophosphatasia	17.5%
67	Propionic acidemia	17.5%
68	Dihydropyrimidine Dehydrogenase Deficiency	17.5%
69	Myelinolysis, Central Pontine	17.2%
70	Hypoalphalipoproteinemias	17%
71	Lipid Metabolism Disorders	16.3%
72	Ataxia Telangiectasia	16.2%
73	Reye Syndrome	16%
74	Hepatic Encephalopathy	16%
75	Glycosuria, Renal	15.9%
76	Familial Periodic Paralysis	15.5%
77	Brain Diseases, Metabolic	15.1%
78	Renal Aminoacidurias	14.8%
79	Fanconi Syndrome	14.8%
80	Pseudohypoaldosteronism	14.8%
81	Liddle Syndrome	14.8%
82	Antley-Bixler Syndrome Phenotype	14.7%
83	Kernicterus	14.4%
84	Wernicke Encephalopathy	14.3%
85	Xanthomatosis	14.1%
86	Dyslipidemias	14.1%
87	Xanthoma	14.1%
88	Gout	13.9%
89	Porphyrias, Hepatic	13.6%
90	Nutrition Disorders	13.4%
91	Fanconi Anemia	13.4%
92	Lipomatosis	13%
93	Cystic Fibrosis	12.8%
94	Congenital Hyperinsulinism	12.8%
95	Aicardi's syndrome	12.8%
96	Friedreich Ataxia	12.4%
97	Gaucher Disease	12.1%
98	CHARGE Syndrome	12%
99	Bloom Syndrome	11.9%
100	Myasthenic Syndromes, Congenital	11.7%
101	Xeroderma Pigmentosum	11.7%
102	Optic Atrophy, Hereditary, Leber	11.7%
103	Neoplastic Syndromes, Hereditary	11.3%
104	Nail-Patella Syndrome	11.2%
105	Multiple Epiphyseal Dysplasia	11.1%
106	Osteochondrodysplasias	11.1%
107	Pelger-Huet Anomaly	11.1%
108	Acidosis	10.9%
109	Alkalosis	10.9%
110	Amyloidosis	10.9%
111	Calcinosis	10.9%
112	Hyperglycemia	10.9%
113	Hyperinsulinism	10.9%
114	Hyperkalemia	10.9%
115	Hypernatremia	10.9%
116	Hypoglycemia	10.9%
117	Hypokalemia	10.9%
118	Hyponatremia	10.9%
119	Hypophosphatemia	10.9%
120	Metabolic acidosis	10.9%
121	Iron Overload	10.9%
122	Glycogen Storage Disease Type I	10.5%
123	Glycogen Storage Disease Type V	10.5%
124	Muscular Dystrophy	10.5%
125	HIV Wasting Syndrome	10.5%
126	Dwarfism	10.4%
127	Osteogenesis Imperfecta	10.2%
128	Diabetes Mellitus	10.2%
129	Muscular Dystrophy, Duchenne	10.1%
130	Dehydration	10%
131	Water Intoxication	10%
132	Osteomalacia	10%
133	Kartagener Syndrome	10%
134	Achlorhydria	10%
135	Osteoporosis	10%
136	Bone Demineralization, Pathologic	10%
137	Post-Traumatic Osteoporosis	10%
138	Celiac Disease	10%
139	Sprue, Tropical	10%
140	Steatorrhea	10%
141	Sprue	10%
142	Anemia, Sickle Cell	9.9%
143	Thalassemia	9.9%
144	Marfan Syndrome	9.9%
145	Mitochondrial Myopathies	9.8%
146	Alstrom Syndrome	9.6%
147	HIV-Associated Lipodystrophy Syndrome	9.6%
148	Autoimmune Lymphoproliferative Syndrome	9.5%
149	Prader-Willi Syndrome	9.5%
150	Angioedemas, Hereditary	9.4%
151	Smith-Magenis syndrome	9.4%
152	Hypokalemic periodic paralysis	9.2%
153	Glycosuria	9.2%
154	Tuberous Sclerosis	9.1%
155	Beckwith-Wiedemann Syndrome	9%
156	Wolf-Hirschhorn Syndrome	9%
157	Cystinuria	8.9%
158	Myotonic Dystrophy	8.9%
159	Holoprosencephaly	8.7%
160	Wiskott-Aldrich Syndrome	8.7%
161	Fragile X Syndrome	8.6%
162	Kallmann Syndrome	8.6%
163	Cri-du-Chat Syndrome	8.6%
164	Down Syndrome	8.6%
165	Trisomy 21	8.6%
166	Necrobiosis Lipoidica Diabeticorum	8.5%
167	Arthritis, Gouty	8.3%
168	Diabetic Ketoacidosis	8.3%
169	Dystonia Musculorum Deformans	8.2%
170	Renal Osteodystrophy	8.2%
171	Renal rickets	8.2%
172	Kearns-Sayre syndrome	8.1%
173	Huntington Disease	8%
174	Deformity	8%
175	Ectodermal Dysplasia	7.7%
176	Aplasia Cutis Congenita	7.7%
177	Rubinstein-Taybi Syndrome	7.7%
178	Nesidioblastosis	7.5%
179	Variegate Porphyria	7.5%
180	Acute intermittent porphyria	7.5%
181	Porphyria Cutanea Tarda	7.5%
182	Amyotrophic Lateral Sclerosis	7.4%
183	Adiposis Dolorosa	7.4%
184	Fetal Diseases	7.3%
185	Williams Syndrome	6.9%
186	Child Nutrition Disorders	6.9%
187	Hypervitaminosis A	6.9%
188	Infant Nutrition Disorders	6.9%
189	Malnutrition	6.9%
190	Polycystic Kidney Diseases	6.6%
191	Dandy-Walker Syndrome	6.6%
192	Familial Mediterranean Fever	6.4%
193	Lafora Disease	6.3%
194	Unverricht-Lundborg Syndrome	6.3%
195	Retinal Dysplasia	6.3%
196	Aniridia	6.3%
197	Epidermolysis Bullosa	6.2%
198	Acidosis, Lactic	6.2%
199	Calciphylaxis	6.2%
200	Hemosiderosis	6.2%
201	Ketosis	6.2%
202	Ketonuria	6.2%
203	Ketoacidosis	6.2%
204	Ketonemia	6.2%
205	Vascular calcification	6.2%
206	Rett Syndrome	6.1%
207	Marchiafava-Bignami Disease	6.1%
208	Primary Ciliary Dyskinesia	6.1%
209	Meconium Aspiration Syndrome	5.9%
210	Meningoencephalitis	5.9%
211	Cerebral Amyloid Angiopathy	5.8%
212	Myotonia Congenita	5.8%
213	Tetany	5.7%
214	Acidosis, Respiratory	5.6%
215	Alkalosis, Respiratory	5.6%
216	Insulin Resistance	5.6%
217	Osteoporosis, Postmenopausal	5.6%
218	Duane Retraction Syndrome	5.6%
219	Welander Distal Myopathy	5.5%
220	Leukomalacia, Periventricular	5.5%
221	Sickle Cell Trait	5.5%
222	Pseudoxanthoma Elasticum	5.5%
223	Encephalomyelitis	5.5%
224	Cutis Laxa	5.4%
225	Retinitis Pigmentosa	5.4%
226	Pigmentary retinopathy	5.4%
227	Porokeratosis	5.4%
228	Keratoderma, Palmoplantar	5.4%
229	Chronic granulomatous disease	5.4%
230	Mobius Syndrome	5.4%
231	Subdural Effusion	5.3%
232	Pneumocephalus	5.3%
233	Brain Abscess	5.3%
234	Gestational Diabetes	5.2%
235	Latent Autoimmune Diabetes in Adults	5.2%
236	Dementia, Vascular	5.2%
237	Diabetes Mellitus, Experimental	5.2%
238	Nephrocalcinosis	5.2%
239	Multiple System Atrophy	5.1%
240	Hypercholesterolemia	5%
241	Hyperlipoproteinemias	5%
242	Hypertriglyceridemia	5%
243	Peutz-Jeghers Syndrome	5%
244	Thrombasthenia	5%
245	Antithrombin III Deficiency	5%
246	Protein C Deficiency	5%
247	Afibrinogenemia	5%
248	Factor VII Deficiency	5%
249	Factor X Deficiency	5%
250	Factor XII Deficiency	5%
251	Hemophilia A	5%
252	Activated Protein C Resistance	5%
253	Factor II deficiency	5%
254	Factor VIII Deficiency	5%
255	Factor V deficiency	5%
256	Factor XI Deficiency	5%
257	Hypoprothrombinemias	5%
258	Anemia, Diamond-Blackfan	4.9%
259	Xeroderma	4.8%
260	Acute Chest Syndrome	4.8%
261	Basal Cell Nevus Syndrome	4.8%
262	Primary amyloidosis	4.8%
263	Multiple Endocrine Neoplasia	4.7%
264	Akinetic Mutism	4.7%
265	Anoxic Encephalopathy	4.7%
266	Basal Ganglia Diseases	4.7%
267	Brain Damage, Chronic	4.7%
268	Cerebellar Diseases	4.7%
269	Encephalitis	4.7%
270	Encephalomalacia	4.7%
271	Epilepsy	4.7%
272	Hydrocephalus	4.7%
273	Congenital Hydrocephalus	4.7%
274	Hypothalamic Diseases	4.7%
275	Thalamic Diseases	4.7%
276	Intracranial Hypertension	4.7%
277	Aura	4.7%
278	Leukoencephalopathy	4.7%
279	Neuroaxonal Dystrophies	4.7%
280	Headache Disorders	4.7%
281	Intracranial Hypotension	4.7%
282	Brain Edema	4.7%
283	Brain Hypoxia	4.7%
284	Aqueductal Stenosis	4.7%
285	Congenital Hypothyroidism	4.7%
286	Dermatitis, Atopic	4.6%
287	Brain Injuries	4.5%
288	Lewy Body Disease	4.5%
289	Brain Neoplasms	4.5%
290	Ocular Motility Disorders	4.5%
291	Cyclophoria	4.5%
292	Behcet Syndrome	4.3%
293	Cerebrovascular Disorders	4.3%
294	Cerebrovascular Insufficiency	4.3%
295	Dementia	4.3%
296	Charcot-Marie-Tooth Disease	4.3%
297	Frontotemporal dementia	4.3%
298	Basal Ganglia Cerebrovascular Disease	4.2%
299	CREST Syndrome	4.1%
300	Epilepsy, Post-Traumatic	4.1%
301	Parkinsonian Disorders	4.1%
302	Abdominal Cramps	4.1%
303	Abnormalities, Drug-Induced	4.1%
304	Amniotic Band Syndrome	4.1%
305	Asphyxia Neonatorum	4.1%
306	Infant, Premature, Diseases	4.1%
307	Situs Inversus	4.1%
308	Infantile Colic	4.1%
309	Brain Death	4%
310	Epidural Abscess	4%
311	Meningitis	3.9%
312	Movement Disorders	3.9%
313	Pachymeningitis	3.9%
314	Spinal Cord Diseases	3.9%
315	Amblyopia	3.9%
316	Toxoplasmosis, Congenital	3.9%
317	Subacute Combined Degeneration	3.9%
318	Nephroblastoma	3.8%
319	Classical Lissencephalies and Subcortical Band Heterotopias	3.8%
320	Eye Abnormalities	3.8%
321	Cardiovascular Abnormalities	3.8%
322	Skin Abnormalities	3.7%
323	Lymphatic Abnormalities	3.7%
324	Congenital Microtia	3.7%
325	Progressive supranuclear palsy	3.7%
326	Anemia, Neonatal	3.7%
327	Persistent Fetal Circulation Syndrome	3.7%
328	Congenital nystagmus	3.7%
329	Congenital diaphragmatic hernia	3.7%
330	Umbilical hernia	3.7%
331	Myelitis	3.7%
332	Central Nervous System Infection	3.7%
333	Polycystic Kidney, Autosomal Dominant	3.7%
334	Hyperkeratosis, Epidermolytic	3.6%
335	Deficiency Diseases	3.6%
336	Starvation	3.6%
337	Refeeding Syndrome	3.6%
338	Stiff-Person Syndrome	3.6%
339	Dural Arteriovenous Fistula	3.6%
340	Adenomatous Polyposis Coli	3.6%
341	Amnesia, Transient Global	3.5%
342	Posterior Leukoencephalopathy Syndrome	3.5%
343	Posterior reversible encephalopathy syndrome	3.5%
344	Urogenital Abnormalities	3.5%
345	Neonatal Abstinence Syndrome	3.4%
346	Fetal Growth Retardation	3.4%
347	Fetal Hypoxia	3.4%
348	Fetal Alcohol Spectrum Disorders	3.4%
349	Syphilis, Congenital	3.4%
350	Anencephaly	3.4%
351	Leukoencephalopathy, Progressive Multifocal	3.3%
352	Vascular Headaches	3.2%
353	Meige Syndrome	3.2%
354	Cerebral Ventriculitis	3.2%
355	Hypoxia-Ischemia, Brain	3.2%
356	Central Nervous System Cysts	3.2%
357	Neuroleptic Malignant Syndrome	3.2%
358	Hydranencephaly	3.2%
359	Neural Tube Defects	3.2%
360	Tethered Cord Syndrome	3.2%
361	Iniencephaly	3.2%
362	Craniorachischisis	3.2%
363	Exencephaly	3.2%
364	Septo-Optic Dysplasia	3.2%
365	Cortical Dysplasia	3.2%
366	Malformations of Cortical Development	3.2%
367	Parkinson Disease	3.2%
368	Chorioamnionitis	3.2%
369	Cerebellar Neoplasms	3.1%
370	Lupus Vasculitis, Central Nervous System	3.1%
371	Prion Diseases	3.1%
372	Limbic Encephalitis	3%
373	Creutzfeldt-Jakob disease	3%
374	Papillon-Lefevre Disease	3%
375	Abnormalities, Radiation-Induced	2.9%
376	Spinal Cord Injuries	2.9%
377	Spinal Muscular Atrophy	2.8%
378	Progressive Muscular Atrophy	2.8%
379	Asterixis	2.8%
380	Ballismus	2.8%
381	Obesity	2.8%
382	Vasculitis, Central Nervous System	2.8%
383	Ophthalmia Neonatorum	2.7%
384	Hydrops Fetalis	2.7%
385	Striatonigral Degeneration	2.7%
386	Poliomyelitis	2.7%
387	Presenile dementia	2.7%
388	Senile dementia	2.7%
389	Chronic Fatigue Syndrome	2.7%
390	Ophthalmoplegic Migraine	2.6%
391	Restless Legs Syndrome	2.6%
392	Cranial nerve diseases	2.6%
393	Demyelinating Diseases	2.6%
394	Demyelination	2.6%
395	Neuromuscular Diseases	2.6%
396	Chronobiology Disorders	2.6%
397	Toxoplasmosis, Cerebral	2.6%
398	Maxillofacial Abnormalities	2.6%
399	Miller Fisher Syndrome	2.6%
400	Meningitis, Bacterial	2.6%
401	Meningitis, Fungal	2.6%
402	Dextrocardia	2.6%
403	Multiple Endocrine Neoplasia Type 1	2.6%
404	Leukoencephalitis, Acute Hemorrhagic	2.5%
405	Brain Hemorrhage, Traumatic	2.5%
406	Myoclonic Epilepsy	2.5%
407	Epilepsy, Temporal Lobe	2.5%
408	Epilepsy, Rolandic	2.5%
409	Benign Rolandic Epilepsy	2.5%
410	Shy-Drager Syndrome	2.5%
411	Turner Syndrome	2.5%
412	Cerebral Palsy	2.5%
413	Epilepsies, Partial	2.5%
414	Epilepsy, Generalized	2.5%
415	Pseudotumor Cerebri	2.5%
416	Hypertensive Encephalopathy	2.5%
417	Simple Partial Seizures	2.5%
418	Epilepsy, Reflex	2.5%
419	Headache Disorders, Primary	2.5%
420	Headache Disorders, Secondary	2.5%
421	Medication overuse headache	2.5%
422	Myelitis, Transverse	2.5%
423	Paraneoplastic Cerebellar Degeneration	2.5%
424	Trauma, Nervous System	2.4%
425	Akathisia, Drug-Induced	2.4%
426	Motor Neuron Disease	2.4%
427	Nervous System Neoplasms	2.4%
428	Neurologic Manifestations	2.4%
429	Neurotoxicity Syndromes	2.4%
430	Basal Ganglia Hemorrhage	2.4%
431	Brain Injuries, Diffuse	2.4%
432	Traumatic Brain Injury	2.4%
433	Cerebellar Ataxia	2.4%
434	Supratentorial Neoplasms	2.4%
435	Opsoclonus-Myoclonus Syndrome	2.4%
436	Polyradiculoneuropathy	2.3%
437	Polyradiculoneuritis	2.3%
438	Pituitary Diseases	2.3%
439	Carotid Artery Injuries	2.3%
440	Scimitar Syndrome	2.3%
441	Carotid Artery Diseases	2.3%
442	Brain Ischemia	2.3%
443	Cerebrovascular accident	2.3%
444	Kluver-Bucy Syndrome	2.3%
445	Vasospasm, Intracranial	2.3%
446	Intracranial Arterial Diseases	2.3%
447	Spinal Cord Neoplasms	2.3%
448	Persistent Vegetative State	2.2%
449	Sleep Wake Disorders	2.2%
450	Klinefelter Syndrome	2.2%
451	Pituitary Adenoma	2.2%
452	Pituitary Neoplasms	2.2%
453	Pituitary Apoplexy	2.1%
454	Prune Belly Syndrome	2.1%
455	Twins, Conjoined	2.1%
456	Waardenburg Syndrome	2.1%
457	Brain Infarction	2.1%
458	MPTP Poisoning	2.1%
459	Encephalomyelitis, Acute Disseminated	2.1%
460	Intracranial Embolism and Thrombosis	2.1%
461	Dyskinesia, Drug-Induced	2.1%
462	Kwashiorkor	2.1%
463	Magnesium Deficiency	2.1%
464	Potassium Deficiency	2.1%
465	Protein Deficiency	2.1%
466	Avitaminosis	2.1%
467	Denys-Drash Syndrome	2%
468	Arachnoiditis	2%
469	Aseptic Meningitis	2%
470	Syringomyelia	2%
471	Essential Tremor	2%
472	Familial Tremor	2%
473	Pneumorrhachis	2%
474	Writer's Cramp	2%
475	Anophthalmos	2%
476	Anus, Imperforate	2%
477	Microphthalmos	2%
478	Paralysis, Obstetric	2%
479	Retinopathy of Prematurity	2%
480	Limb Deformities, Congenital	2%
481	Craniofacial Abnormalities	2%
482	Anorectal Malformations	2%
483	Bronchopulmonary Dysplasia	1.9%
484	POEMS Syndrome	1.9%
485	Auditory Perceptual Disorders	1.9%
486	Central Nervous System Fungal Infections	1.9%
487	Conus Medullaris Syndrome	1.9%
488	Spinal Cord Vascular Diseases	1.9%
489	Autonomic Dysreflexia	1.8%
490	Complex Regional Pain Syndromes	1.8%
491	Blepharophimosis	1.8%
492	Laryngostenosis	1.8%
493	Mouth Abnormalities	1.8%
494	Respiratory Distress Syndrome, Newborn	1.8%
495	Esophageal Atresia	1.8%
496	Intestinal Atresia	1.8%
497	Horseshoe Kidney	1.8%
498	Pectus excavatum	1.8%
499	Lambert-Eaton Myasthenic Syndrome	1.8%
500	Klippel-Feil Syndrome	1.8%
501	Gastroschisis	1.8%
502	Synostosis	1.8%
503	Acrodermatitis	1.8%
504	Lymphangiectasis, Intestinal	1.8%
505	Gianotti-Crosti Syndrome	1.8%
506	AIDS Dementia Complex	1.8%
507	Microcephaly	1.7%
508	Macrocephaly	1.7%
509	Central Nervous System Bacterial Infections	1.7%
510	Obesity, Abdominal	1.7%
511	Craniosynostosis	1.7%
512	Syndactyly	1.7%
513	Brachycephaly	1.7%
514	Meningomyelocele	1.7%
515	Spina Bifida	1.7%
516	Arthrogryposis	1.7%
517	Choanal Atresia	1.7%
518	Tracheobronchomegaly	1.7%
519	Laryngocele	1.7%
520	Peripheral Nerve Injuries	1.7%
521	Choledochal Cyst	1.7%
522	Hermaphroditism	1.7%
523	Disorders of Sex Development	1.7%
524	Myasthenia Gravis	1.7%
525	Cryptorchidism	1.7%
526	Hypospadias	1.7%
527	Noonan Syndrome	1.6%
528	Tuberculosis, Meningeal	1.6%
529	Guillain-Barre Syndrome	1.6%
530	Moyamoya Disease	1.6%
531	Pediatric Obesity	1.6%
532	Sleep Disorders, Circadian Rhythm	1.6%
533	Laryngomalacia	1.6%
534	Pectus carinatum	1.6%
535	Meningocele	1.6%
536	Encephalocele	1.6%
537	Bladder Exstrophy	1.6%
538	Epispadias	1.6%
539	Multicystic Dysplastic Kidney	1.5%
540	Botulism	1.5%
541	Juvenile Myoclonic Epilepsy	1.5%
542	Myoclonic Epilepsies, Progressive	1.5%
543	Acrocephalosyndactylia	1.5%
544	Vertebral Artery Dissection	1.5%
545	Putaminal Hemorrhage	1.5%
546	Scrapie	1.5%
547	Central Cord Syndrome	1.5%
548	Chorea	1.5%
549	Neuromyelitis Optica	1.4%
550	Post-Traumatic Headache	1.4%
551	Tension Headache	1.4%
552	Epilepsy, Complex Partial	1.4%
553	Migraine Disorders	1.4%
554	Abdominal Migraine	1.4%
555	Status Migrainosus	1.4%
556	Cervicogenic Headache	1.4%
557	Porencephaly	1.4%
558	Cleft Palate	1.3%
559	Olfactory Nerve Injuries	1.3%
560	Diffuse Axonal Injury	1.3%
561	Dysautonomia	1.3%
562	Vagus Nerve Disorder	1.3%
563	Glossopharyngeal Neuralgia	1.3%
564	Abducens Nerve Diseases	1.3%
565	Heavy Metal Poisoning, Nervous System	1.3%
566	Neuromuscular Junction Diseases	1.3%
567	Tauopathies	1.3%
568	Trochlear Nerve Diseases	1.3%
569	Peripheral Nervous System Diseases	1.3%
570	Brain Stem Neoplasms	1.3%
571	Brain Concussion	1.3%
572	Giant Cell Arteritis	1.3%
573	Temporal Arteritis	1.3%
574	Horner Syndrome	1.3%
575	Jaw Abnormalities	1.3%
576	Infarction, Middle Cerebral Artery	1.3%
577	Infarction, Anterior Cerebral Artery	1.3%
578	Infarction, Posterior Cerebral Artery	1.3%
579	Meningitis, Cryptococcal	1.3%
580	Meningitis, Listeria	1.3%
581	Subacute Sclerosing Panencephalitis	1.3%
582	Meningitis, Haemophilus	1.3%
583	Meningitis, Pneumococcal	1.3%
584	Cerebral Infarction	1.3%
585	Brain Stem Infarctions	1.3%
586	Empty Sella Syndrome	1.3%
587	Hyperpituitarism	1.3%
588	Hypopituitarism	1.3%
589	Hypophysitis	1.3%
590	Subarachnoid Hemorrhage, Traumatic	1.3%
591	Carotid Artery, Internal, Dissection	1.3%
592	Ascorbic Acid Deficiency	1.3%
593	Vitamin A Deficiency	1.3%
594	Vitamin D Deficiency	1.3%
595	Vitamin E Deficiency	1.3%
596	Marasmus	1.3%
597	Cerebral Arterial Diseases	1.3%
598	Vertebrobasilar Insufficiency	1.3%
599	Basilar Artery Stenosis	1.3%
600	Vertebral Artery Stenosis	1.3%
601	Intracranial Hemorrhage, Hypertensive	1.3%
602	Transient Cerebral Ischemia	1.3%
603	Progressive bulbar palsy	1.2%
604	Bulbar palsy	1.2%
605	Facial Nerve Injuries	1.2%
606	Myopathy	1.2%
607	Optic Neuropathy	1.2%
608	Brain Contusion	1.2%
609	Facial Nerve Diseases	1.2%
610	Craniocerebral Trauma	1.2%
611	Parasomnia	1.2%
612	Dyssomnias	1.2%
613	Jet Lag Syndrome	1.2%
614	Vestibulocochlear Nerve Diseases	1.2%
615	Decerebrate State	1.2%
616	Hemiparesis	1.2%
617	Meningism	1.2%
618	Paresis	1.2%
619	Seizures	1.2%
620	Sensation Disorders	1.2%
621	Central Nervous System Neoplasms	1.2%
622	Complex partial seizures	1.2%
623	Monoparesis	1.2%
624	Neurogenic Inflammation	1.2%
625	Gait Disorders, Neurologic	1.2%
626	Neuromuscular Manifestations	1.2%
627	Sweating, Gustatory	1.2%
628	Auriculotemporal Syndrome	1.2%
629	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	1.2%
630	Torticollis	1.2%
631	Causalgia	1.2%
632	Carotid Stenosis	1.2%
633	Intracranial Aneurysm	1.2%
634	Intracranial Arteriosclerosis	1.2%
635	Cerebral Atherosclerosis	1.2%
636	Subarachnoid Hemorrhage	1.2%
637	Cerebral Arteriosclerosis	1.2%
638	Cerebral Hemorrhage	1.2%
639	Cerebral Thrombosis	1.2%
640	Intracranial Embolism	1.2%
641	Intracranial Thrombosis	1.2%
642	Myasthenia Gravis, Autoimmune, Experimental	1.1%
643	Multiple Sclerosis	1.1%
644	Pupil Disorders	1.1%
645	Neurobehavioral Manifestations	1.1%
646	Paraneoplastic Encephalomyelitis	1.1%
647	Uveomeningoencephalitic Syndrome	1.1%
648	Sturge-Weber Syndrome	1.1%
649	Vertigo	1.1%
650	Alcohol-Induced Disorders, Nervous System	1.1%
651	Amelia	1.1%
652	Arachnodactyly	1.1%
653	Ectopia Cordis	1.1%
654	Ectromelia	1.1%
655	Hemimelia	1.1%
656	Phocomelia	1.1%
657	Sirenomelia	1.1%
658	Polydactyly	1.1%
659	Brachydactyly	1.1%
660	Plagiocephaly	1.1%
661	Lower Extremity Deformities, Congenital	1.1%
662	Upper Extremity Deformities, Congenital	1.1%
663	Single umbilical artery	1.1%
664	Carotid Artery Thrombosis	1.1%
665	Vitamin K Deficiency	1.1%
666	Ophthalmoplegia	1.1%
667	External Ophthalmoplegia	1.1%
668	Voice Disorders	1%
669	Voice Disturbance	1%
670	Alice in Wonderland Syndrome	1%
671	Poland Syndrome	1%
672	Aortic coarctation	1%
673	Cor Triatriatum	1%
674	Coronary Vessel Anomalies	1%
675	Dental Enamel Hypoplasia	1%
676	Patent ductus arteriosus	1%
677	Ebstein Anomaly	1%
678	Heart Septal Defects	1%
679	Hyaline Membrane Disease	1%
680	Hypodontia	1%
681	Macrostomia	1%
682	Microstomia	1%
683	Tetralogy of Fallot	1%
684	Transposition of Great Vessels	1%
685	Hypoplastic Left Heart Syndrome	1%
686	May-Thurner Syndrome	1%
687	Craniofacial Dysostosis	1%
688	Wolff-Parkinson-White Syndrome	1%
689	Vocal Cord Paralysis	1%
690	Spinal Cord Ischemia	1%
691	Dermal Sinus	1%
692	Spina Bifida Cystica	1%
693	Spina Bifida Occulta	1%
694	Lissencephaly	1%
695	Polymicrogyria	1%
696	Pachygyria	1%
697	Schizencephaly	1%
698	Periventricular Nodular Heterotopia	1%
699	Tuberculosis, Central Nervous System	1%
700	Reflex, Abnormal	0.9%
701	Hyporeflexia	0.9%
702	Hyperreflexia	0.9%
703	Reflex Sympathetic Dystrophy	0.9%
704	Nocturnal Myoclonus Syndrome	0.9%
705	Long QT Syndrome	0.9%
706	Platybasia	0.9%
707	Tricuspid Atresia	0.9%
708	Arrhythmogenic Right Ventricular Dysplasia	0.9%
709	Gonadal Dysgenesis	0.9%
710	Bronchomalacia	0.9%
711	Adrenogenital Syndrome	0.9%
712	Tracheomalacia	0.9%
713	Ovotesticular Disorders of Sex Development	0.9%
714	Alcohol Withdrawal Seizures	0.9%
715	Neuroaspergillosis	0.9%
716	Folic Acid Deficiency	0.9%
717	Pellagra	0.9%
718	Thiamine Deficiency	0.9%
719	Vitamin B 12 Deficiency	0.9%
720	Vitamin B 6 Deficiency	0.9%
721	Pyridoxine Deficiency	0.9%
722	Acrodynia	0.9%
723	Lateral Medullary Syndrome	0.8%
724	Pseudorabies	0.8%
725	Hyperandrogenism	0.8%
726	Cluster Headache	0.8%
727	Migraine with Aura	0.8%
728	Familial Hemiplegic Migraine	0.8%
729	Chronic Paroxysmal Hemicrania	0.8%
730	SUNCT Syndrome	0.8%
731	Paroxysmal Hemicrania	0.8%
732	Neurosyphilis	0.8%
733	Micrognathism	0.8%
734	Pierre Robin Syndrome	0.8%
735	Cerebrospinal Fluid Otorrhea	0.8%
736	Cerebrospinal Fluid Rhinorrhea	0.8%
737	Neuritis, Autoimmune, Experimental	0.8%
738	Gait Ataxia	0.8%
739	Hematoma, Subdural	0.8%
740	Hematoma, Epidural, Cranial	0.8%
741	Tardive Dyskinesia	0.8%
742	Choroid Plexus Papilloma	0.8%
743	Lyme Neuroborreliosis	0.8%
744	Acoustic Neuroma	0.8%
745	Hyperprolactinemia	0.8%
746	Subclavian Steal Syndrome	0.8%
747	Pick Disease of the Brain	0.8%
748	West Nile Fever	0.8%
749	Retrognathia	0.7%
750	Akathisia	0.7%
751	Restlessness	0.7%
752	Psychomotor Agitation	0.7%
753	Scurvy	0.7%
754	Prognathism	0.7%
755	Acromegaly	0.7%
756	Sinus Thrombosis, Intracranial	0.7%
757	Neuritis	0.7%
758	Polyneuritis	0.7%
759	Radiculitis	0.7%
760	Polyneuropathy	0.7%
761	Mononeuritis	0.7%
762	Mononeuropathies	0.7%
763	Brachial Plexus Neuropathies	0.7%
764	Radiculopathy	0.7%
765	Mononeuropathy Multiplex	0.7%
766	Nerve Root Compression	0.7%
767	Beriberi	0.7%
768	Optic Nerve Glioma	0.7%
769	Coma, Post-Head Injury	0.7%
770	Brachial Plexus Neuritis	0.6%
771	Neuralgic Amyotrophy	0.6%
772	Gait Apraxia	0.6%
773	Myositis	0.6%
774	Optic Atrophy	0.6%
775	Optic Neuritis	0.6%
776	Papilledema	0.6%
777	Strabismus	0.6%
778	Tolosa-Hunt Syndrome	0.6%
779	Isaacs syndrome	0.6%
780	Arsenic Poisoning	0.6%
781	Myotonic Disorders	0.6%
782	Diabetic Neuropathies	0.6%
783	Facial Injuries	0.6%
784	Facial Neuralgia	0.6%
785	Diabetic Amyotrophy	0.6%
786	Diabetic Autonomic Neuropathy	0.6%
787	Sleep Talking	0.6%
788	Manganese Poisoning	0.6%
789	Sleep Disorders, Intrinsic	0.6%
790	Orthostatic intolerance	0.6%
791	Anosmia	0.6%
792	Ataxia	0.6%
793	Athetosis	0.6%
794	Catalepsy	0.6%
795	Dystonia	0.6%
796	Hemiplegia	0.6%
797	Locked-In Syndrome	0.6%
798	Meningeal Neoplasms	0.6%
799	Muscle Hypertonia	0.6%
800	Muscle hypotonia	0.6%
801	Myoclonus	0.6%
802	Myotonia	0.6%
803	Neuralgia	0.6%
804	Paraplegia	0.6%
805	Pseudobulbar Palsy	0.6%
806	Quadriplegia	0.6%
807	Spasm	0.6%
808	Spastic Paraplegia	0.6%
809	Status Epilepticus	0.6%
810	Taste Disorders	0.6%
811	Tremor	0.6%
812	Monoplegia	0.6%
813	Hypokinesia	0.6%
814	Paraparesis	0.6%
815	Bradykinesia	0.6%
816	Waxy flexibility	0.6%
817	Action Tremor	0.6%
818	Resting Tremor	0.6%
819	Dysosmia	0.6%
820	Quadriparesis	0.6%
821	Mercury Poisoning, Nervous System	0.6%
822	Olfaction Disorders	0.6%
823	Myokymia	0.6%
824	Lead Poisoning, Nervous System	0.6%
825	Vestibular Neuronitis	0.6%
826	Somatosensory Disorders	0.6%
827	Neuropathic pain	0.6%
828	Hyperkinesia	0.6%
829	Intention tremor	0.6%
830	Anemia, Pernicious	0.6%
831	Prolactinoma	0.6%
832	Growth Hormone-Secreting Pituitary Adenoma	0.6%
833	Aortopulmonary Septal Defect	0.6%
834	Double Outlet Right Ventricle	0.6%
835	Endocardial Cushion Defects	0.6%
836	Multiple Sclerosis, Chronic Progressive	0.6%
837	Multiple Sclerosis, Relapsing-Remitting	0.6%
838	Myocardial bridging	0.6%
839	Aorticopulmonary Septal Defect	0.6%
840	Hand-Arm Vibration Syndrome	0.6%
841	Vision Disorders	0.6%
842	Metamorphopsia	0.6%
843	Visual Impairment	0.6%
844	Fibromyalgia	0.6%
845	Optic Neuropathy, Ischemic	0.6%
846	Anterior Ischemic Optic Neuropathy	0.6%
847	Medial Tibial Stress Syndrome	0.6%
848	Facial Hemiatrophy	0.6%
849	Melkersson-Rosenthal Syndrome	0.6%
850	Anisocoria	0.6%
851	Confusion	0.6%
852	Facial paralysis	0.6%
853	Lethargy	0.6%
854	Memory Disorders	0.6%
855	Muscle Cramp	0.6%
856	Perceptual Disorders	0.6%
857	Psychomotor Disorders	0.6%
858	Tonic Pupil	0.6%
859	Eosinophilia-Myalgia Syndrome	0.6%
860	Anhedonia	0.6%
861	Disorientation	0.6%
862	Facial Paresis	0.6%
863	Memory Loss	0.6%
864	Hemisensory Neglect	0.6%
865	Dysacusis	0.6%
866	Sleep Bruxism	0.6%
867	Muscular Atrophy	0.6%
868	Respiratory Paralysis	0.6%
869	Mandibulofacial Dysostosis	0.5%
870	Romano-Ward Syndrome	0.5%
871	Anterior Spinal Artery Syndrome	0.5%
872	Waterhouse-Friderichsen Syndrome	0.5%
873	Consciousness Disorders	0.5%
874	Mental Retardation	0.5%
875	Muscle Weakness	0.5%
876	Depressed Level of Consciousness	0.5%
877	Mental deficiency	0.5%
878	Intellectual Disability	0.5%
879	Bell Palsy	0.5%
880	Catatonia	0.5%
881	Herpes Zoster Oticus	0.5%
882	Aphonia	0.5%
883	Sleep Deprivation	0.5%
884	Dysphonia	0.5%
885	Tarsal Tunnel Syndrome	0.5%
886	Cauda Equina Syndrome	0.5%
887	Hematoma, Subdural, Intracranial	0.5%
888	Hematoma, Subdural, Chronic	0.5%
889	Hematoma, Subdural, Acute	0.5%
890	Malaria, Cerebral	0.5%
891	Neurocysticercosis	0.5%
892	Myalgia	0.5%
893	Arteriovenous fistula	0.5%
894	Carpal Tunnel Syndrome	0.5%
895	neurofibroma	0.5%
896	Sciatica	0.5%
897	Cavernous Sinus Thrombosis	0.5%
898	Sagittal Sinus Thrombosis	0.5%
899	Hoarseness	0.5%
900	Alcohol Withdrawal Delirium	0.5%
901	Nelson Syndrome	0.4%
902	Truncus Arteriosus, Persistent	0.4%
903	Goldenhar Syndrome	0.4%
904	Talipes	0.4%
905	Sciatic Neuropathy	0.4%
906	Ulnar Neuropathies	0.4%
907	Lesion of Sciatic Nerve	0.4%
908	Ulnar Neuritis	0.4%
909	Radial nerve compression	0.4%
910	Radial Tunnel Syndrome	0.4%
911	Peroneal Neuropathies	0.4%
912	Radial Neuropathy	0.4%
913	Median Neuropathy	0.4%
914	Sciatic Nerve Palsy	0.4%
915	Femoral Neuropathy	0.4%
916	Tibial Neuropathy	0.4%
917	Ulnar Nerve Palsy	0.4%
918	Postural Orthostatic Tachycardia Syndrome	0.4%
919	Radial nerve palsy	0.4%
920	Cubital Tunnel Syndrome	0.3%
921	Thoracic Outlet Syndrome	0.3%
922	Esotropia	0.3%
923	Exotropia	0.3%
924	Hypotension, Orthostatic	0.3%
925	Sleep Apnea Syndromes	0.3%
926	Polymyositis	0.3%
927	Post-Exercise Hypotension	0.3%
928	Disorders of Excessive Somnolence	0.3%
929	Sleep Initiation and Maintenance Disorders	0.3%
930	Night Terrors	0.3%
931	Somnambulism	0.3%
932	Trigeminal Nerve Disorder	0.3%
933	Transient Insomnia	0.3%
934	Sleep Paralysis	0.3%
935	Chronic Insomnia	0.3%
936	REM Sleep Behavior Disorder	0.3%
937	Hypersomnia	0.3%
938	Dysgeusia	0.3%
939	Formication	0.3%
940	Hyperalgesia	0.3%
941	Hyperesthesia	0.3%
942	Hypesthesia	0.3%
943	Language Disorders	0.3%
944	Numbness	0.3%
945	Paresthesia	0.3%
946	Paraparesis, Spastic	0.3%
947	Trismus	0.3%
948	Epilepsia Partialis Continua	0.3%
949	Hypogeusia	0.3%
950	Meningeal Carcinomatosis	0.3%
951	Brown-Sequard Syndrome	0.3%
952	Lockjaw	0.3%
953	Allodynia	0.3%
954	Lead Poisoning, Nervous System, Childhood	0.3%
955	Lead Poisoning, Nervous System, Adult	0.3%
956	Ageusia	0.3%
957	Eye Injuries	0.3%
958	Orbital Myositis	0.3%
959	Diplopia	0.3%
960	Muscle Rigidity	0.3%
961	Muscle Spasticity	0.3%
962	Scotoma	0.3%
963	Photophobia	0.3%
964	Cogwheel Rigidity	0.3%
965	Hemifacial Spasm	0.3%
966	Amaurosis	0.3%
967	Blindness	0.3%
968	Nuchal Rigidity	0.3%
969	Pyomyositis	0.3%
970	Agnosia	0.3%
971	Apraxias	0.3%
972	Hallucinations	0.3%
973	Hemianopsia	0.3%
974	Hyperacusis	0.3%
975	Tinnitus	0.3%
976	Visual Agnosia	0.3%
977	Anosognosia	0.3%
978	Wernicke-Korsakoff Syndrome	0.3%
979	Phonophobia	0.3%
980	Hearing Loss	0.3%
981	Sarcopenia	0.3%
982	Alexia	0.3%
983	Dyslexia	0.3%
984	Amnesia	0.3%
985	Delirium	0.3%
986	Dissociative Amnesia	0.3%
987	Color blindness	0.3%
988	Global Amnesia	0.3%
989	Meningioma	0.3%
990	Congenital clubfoot	0.3%
991	Vertical Talus	0.3%
992	Phantom pain	0.3%
993	Phantom Limb Pain	0.3%
994	Neurofibrosarcoma	0.2%
995	Polyradiculopathy	0.2%
996	Sleep Apnea, Obstructive	0.2%
997	Sleep Apnea, Central	0.2%
998	Narcolepsy	0.2%
999	Trigeminal Neuralgia	0.2%
1000	Kleine-Levin Syndrome	0.2%
1001	Agraphia	0.2%
1002	Anomia	0.2%
1003	Cluttering	0.2%
1004	Language Development Disorders	0.2%
1005	Speech Disorders	0.2%
1006	Syncope	0.2%
1007	Stupor	0.2%
1008	Dysgraphia	0.2%
1009	Presyncope	0.2%
1010	Dyslalia	0.2%
1011	Eye Burns	0.2%
1012	Amaurosis Fugax	0.2%
1013	Blindness, Cortical	0.2%
1014	Dyscalculia	0.2%
1015	Deafness	0.2%
1016	Hearing Loss, Sudden	0.2%
1017	Gerstmann Syndrome	0.2%
1018	Hearing Loss, Bilateral	0.2%
1019	Hearing Loss, High-Frequency	0.2%
1020	Hearing Loss, Mixed Conductive-Sensorineural	0.2%
1021	Prosopagnosia	0.2%
1022	Apraxia, Ideomotor	0.2%
1023	Charles Bonnet Syndrome	0.2%
1024	Hearing Loss, Unilateral	0.2%
1025	Complete Hearing Loss	0.2%
1026	Alien Hand Syndrome	0.2%
1027	Deaf Mutism	0.2%
1028	Dermatomyositis	0.2%
1029	Corneal Scar	0.2%
1030	Retrograde amnesia	0.2%
1031	Amnesia, Anterograde	0.2%
1032	Cataplexy	0.1%
1033	Aphasia	0.1%
1034	Articulation Disorders	0.1%
1035	Echolalia	0.1%
1036	Stuttering	0.1%
1037	Dysphasia	0.1%
1038	Mutism	0.1%
1039	Selective Mutism	0.1%
1040	Corneal Perforation	0.1%
1041	Dysarthria	0.1%
1042	Alexia, Pure	0.1%

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