MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Dyspnea, Paroxysmal

(UMLS:C0013405)

Definition:: A disorder characterized by sudden attacks of respiratory distress in at rest patients with HEART FAILURE and PULMONARY EDEMA. It usually occurs at night after several hours of sleep in a reclining position. Patients awaken with a feeling of suffocation, coughing, a cold sweat, and TACHYCARDIA. When there is significant WHEEZING, it is called cardiac asthma.
UMLS ID:: C0013405
MeSH ID:: D004418

Classification 1:

Name:

Respiratory Tract Diseases
MeSH Tree Number(s):: C08.618.326.396

Classification 2:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.280.434.313

Classification 3:

Name:

Pathological Conditions, Signs and Symptoms
MeSH Tree Number(s):: C23.888.852.371.396

Synonym(s)

Dyspnea, Paroxysmal

Dyspnea, paroxysmal

Paroxysmal dyspnea

Paroxysmal dyspnoea

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Cyclophosphamide		25023062	CTD
2	Pioglitazone		15629744	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Apnea	26.2%
2	Cheyne-Stokes Respiration	26.2%
3	Hyperventilation	26.2%
4	Mouth Breathing	26.2%
5	Tachypnea	26.2%
6	Edema, Cardiac	24.5%
7	Heart Failure, Systolic	23.1%
8	Heart Failure, Diastolic	23.1%
9	Cardiac Output, High	22.4%
10	Myocardial Stunning	22.4%
11	Low Cardiac Output Syndrome	22.4%
12	Hypoventilation	21.9%
13	Hoarseness	18.1%
14	Anoxia	17.4%
15	Hypercapnia	17.4%
16	Hypocapnia	17.4%
17	Hypoxia	17.4%
18	Hyperoxia	17.4%
19	Hypoxemia	17.4%
20	Hemoptysis	16.8%
21	Respiratory Distress Syndrome, Adult	16.3%
22	Myocardial Ischemia	16.3%
23	Aortic Valve Stenosis	15.9%
24	Cardiomyopathy, Dilated	15.9%
25	Pulmonary Valve Stenosis	15.9%
26	Respiratory Aspiration	15.6%
27	Altitude Sickness	15.1%
28	Cardiac Tamponade	15.1%
29	Endocarditis	15.1%
30	Cardiac Arrest	15.1%
31	Pericardial effusion	15.1%
32	Pericarditis	15.1%
33	Pneumopericardium	15.1%
34	Cor pulmonale	15.1%
35	Respiratory Insufficiency	15.1%
36	Ventricular Outflow Obstruction	15.1%
37	Respiratory Depression	15.1%
38	Ventricular Dysfunction	15.1%
39	Cardiomyopathies	15.1%
40	Respiratory Failure	15.1%
41	Pleuropericarditis	15.1%
42	Heart Block	14.9%
43	Tachycardia	14.9%
44	Tachyarrhythmia	14.9%
45	Epistaxis	14.5%
46	Cardiomegaly	14.1%
47	Postpericardiotomy Syndrome	14.1%
48	Sneezing	14.1%
49	Cardiac Hypertrophy	14.1%
50	Myocardial Reperfusion Injury	14%
51	Vocal Cord Dysfunction	13.7%
52	Polydipsia	13.6%
53	Respiratory Distress Syndrome, Newborn	13.6%
54	Tricuspid Atresia	13.2%
55	Arrhythmogenic Right Ventricular Dysplasia	13.2%
56	Hypertrophic Cardiomyopathy	12.8%
57	Hypertrophic obstructive cardiomyopathy	12.8%
58	Long QT Syndrome	12.7%
59	Asthenia	12.6%
60	Body Temperature Changes	12.6%
61	Cyanosis	12.6%
62	Edema	12.6%
63	Failure to Thrive	12.6%
64	Fatigue	12.6%
65	Feminization	12.6%
66	Fetal Distress	12.6%
67	Motion Sickness	12.6%
68	Signs and Symptoms, Digestive	12.6%
69	Skin Manifestations	12.6%
70	Chills	12.6%
71	Lassitude	12.6%
72	Pseudophakia	12.6%
73	Urological Manifestations	12.6%
74	Mobility Limitation	12.6%
75	Somnolence	12.6%
76	Sick Sinus Syndrome	12.6%
77	Intermittent Claudication	12%
78	Rheumatic Heart Disease	12%
79	Supravalvular aortic stenosis	11.8%
80	Lown-Ganong-Levine Syndrome	11.8%
81	Pleural Rub	11.7%
82	Rales	11.7%
83	Respiratory Sounds	11.7%
84	Rhonchi	11.7%
85	Stridor	11.7%
86	Wheezing	11.7%
87	Snoring	11.5%
88	Angina Pectoris	11.2%
89	Granuloma, Laryngeal	11%
90	Adams-Stokes Syndrome	10.9%
91	Atrioventricular Block	10.9%
92	Bundle-Branch Block	10.9%
93	Atrial Premature Complexes	10.9%
94	Sinoatrial Block	10.9%
95	Tachycardia, Paroxysmal	10.9%
96	Supraventricular tachycardia	10.9%
97	Tachycardia, Ventricular	10.9%
98	Tachycardia, Reciprocating	10.9%
99	Coronary heart disease	10.6%
100	Myocardial Infarction	10.6%
101	Acute Coronary Syndrome	10.6%
102	Eye Manifestations	10.5%
103	Neurologic Manifestations	10.5%
104	Reticulocytosis	10.2%
105	Sinus Arrhythmia	9.9%
106	Atrial Fibrillation	9.9%
107	Atrial Flutter	9.9%
108	Ventricular Fibrillation	9.9%
109	Ventricular Flutter	9.9%
110	Parasystole	9.9%
111	Paroxysmal atrial fibrillation	9.9%
112	Bradycardia	9.9%
113	Airway Obstruction	9.9%
114	Aortic Valve Insufficiency	9.9%
115	Restrictive cardiomyopathy	9.9%
116	Choking	9.9%
117	Endocardial Fibroelastosis	9.9%
118	Heart Rupture, Post-Infarction	9.9%
119	Mitral Valve Insufficiency	9.9%
120	Mitral Valve Stenosis	9.9%
121	Myocarditis	9.9%
122	Pericarditis, Constrictive	9.9%
123	Pulmonary Valve Insufficiency	9.9%
124	Tricuspid Valve Insufficiency	9.9%
125	Tricuspid Valve Stenosis	9.9%
126	Ventricular Dysfunction, Left	9.9%
127	Right Ventricular Dysfunction	9.9%
128	Endomyocardial Fibrosis	9.9%
129	Carditis	9.9%
130	Renal Colic	9.9%
131	Respiratory Paralysis	9.9%
132	Abdominal Pain	9.9%
133	Wolff-Parkinson-White Syndrome	9.8%
134	Meconium Aspiration Syndrome	9.4%
135	Romano-Ward Syndrome	9.3%
136	Sudden Cardiac Death	9.2%
137	Left Ventricular Hypertrophy	9.2%
138	Right Ventricular Hypertrophy	9.2%
139	Bronchitis	9%
140	Granuloma, Respiratory Tract	9%
141	Respiratory Tract Fistula	9%
142	Kounis Syndrome	8.9%
143	Tachycardia, Atrioventricular Nodal Reentry	8.9%
144	Tachycardia, Ectopic Atrial	8.9%
145	Tachycardia, Ectopic Junctional	8.9%
146	Sinus Tachycardia	8.9%
147	Torsades de Pointes	8.9%
148	Accelerated Idioventricular Rhythm	8.9%
149	Laryngospasm	8.8%
150	Acute Chest Syndrome	8.8%
151	Aortic coarctation	8.8%
152	Cor Triatriatum	8.8%
153	Coronary Vessel Anomalies	8.8%
154	Patent ductus arteriosus	8.8%
155	Ebstein Anomaly	8.8%
156	Heart Septal Defects	8.8%
157	Hyaline Membrane Disease	8.8%
158	Tetralogy of Fallot	8.8%
159	Transposition of Great Vessels	8.8%
160	Hypoplastic Left Heart Syndrome	8.8%
161	Tracheobronchomegaly	8.8%
162	Coronary Aneurysm	8.7%
163	Bronchial Diseases	8.7%
164	Bacterial Endocarditis	8.7%
165	Lung diseases	8.7%
166	Pleural Diseases	8.7%
167	Thoracic Diseases	8.7%
168	Tracheal Diseases	8.7%
169	Vascular Diseases	8.7%
170	Angina, Unstable	8.5%
171	Hypergammaglobulinemia	8.5%
172	Carcinoid Heart Disease	8.4%
173	Eye pain	8.3%
174	Scimitar Syndrome	8.3%
175	Shock, Cardiogenic	8.2%
176	Postoperative Nausea and Vomiting	8.2%
177	Pleurisy	8.2%
178	Pneumonia	8.2%
179	Lobar Pneumonia	8.2%
180	Tracheitis	8.2%
181	Pneumonitis	8.2%
182	Coronary Thrombosis	8.2%
183	Coronary Artery Disease	8.2%
184	Diabetic Cardiomyopathies	7.9%
185	jaundice	7.9%
186	Acidosis, Respiratory	7.9%
187	Alkalosis, Respiratory	7.9%
188	Cardiomyopathy, Alcoholic	7.9%
189	Sleep Apnea Syndromes	7.9%
190	Chagas Cardiomyopathy	7.9%
191	Bronchial Fistula	7.9%
192	Coronary Occlusion	7.8%
193	Microvascular Angina	7.8%
194	Coronary Stenosis	7.8%
195	ST segment elevation myocardial infarction	7.8%
196	Pathological Conditions, Anatomical	7.8%
197	Bronchopneumonia	7.8%
198	Fetal Hypoxia	7.8%
199	Asthma	7.7%
200	Pleuropneumonia	7.6%
201	Dextrocardia	7.5%
202	Anorexia	7.4%
203	Constipation	7.4%
204	Diarrhea	7.4%
205	Dyspepsia	7.4%
206	Eructation	7.4%
207	Fever	7.4%
208	Flatulence	7.4%
209	Flushing	7.4%
210	Halitosis	7.4%
211	Heartburn	7.4%
212	Hiccough	7.4%
213	Hypercalciuria	7.4%
214	Hyperphagia	7.4%
215	Nausea	7.4%
216	Pallor	7.4%
217	Psychophysiologic Disorders	7.4%
218	Vomiting	7.4%
219	Dyschezia	7.4%
220	Lower Urinary Tract Symptoms	7.4%
221	Urinoma	7.4%
222	Aortic Valve Prolapse	7.4%
223	Tricuspid Valve Prolapse	7.4%
224	Takotsubo Cardiomyopathy	7.4%
225	Voice Disorders	7.3%
226	Voice Disturbance	7.3%
227	Angina Pectoris, Variant	7.2%
228	Laryngeal Diseases	7.2%
229	Nose Diseases	7.2%
230	Sinus Arrest, Cardiac	7.2%
231	Livedo Reticularis	7.2%
232	Pregnancy Complications, Cardiovascular	7%
233	Respiratory Tract Infections	7%
234	Cardiovascular Abnormalities	7%
235	Respiratory Hypersensitivity	6.9%
236	Eye Hemorrhage	6.9%
237	Laryngitis	6.9%
238	Lung Diseases, Fungal	6.9%
239	Rhinitis	6.9%
240	Abdomen, Acute	6.8%
241	Lung Abscess	6.7%
242	Lung Neoplasms	6.7%
243	Pleural Neoplasms	6.7%
244	Tuberculosis, Pulmonary	6.7%
245	Ecchymosis	6.6%
246	Petechiae	6.6%
247	Purpura	6.6%
248	Bronchitis, Chronic	6.6%
249	Aortopulmonary Septal Defect	6.5%
250	Double Outlet Right Ventricle	6.5%
251	Endocardial Cushion Defects	6.5%
252	Myocardial bridging	6.5%
253	Aorticopulmonary Septal Defect	6.5%
254	Coronary Restenosis	6.5%
255	Kartagener Syndrome	6.2%
256	Body Weight	6.2%
257	Bronchiolitis	6%
258	Decerebrate State	6%
259	Hemiparesis	6%
260	Hemothorax	6%
261	Meningism	6%
262	Paresis	6%
263	Pruritus	6%
264	Reperfusion Injury	6%
265	Seizures	6%
266	Sensation Disorders	6%
267	Erythema	6%
268	Complex partial seizures	6%
269	Necrolytic Migratory Erythema	6%
270	Monoparesis	6%
271	Gait Disorders, Neurologic	6%
272	Neuromuscular Manifestations	6%
273	Vasoplegia	6%
274	Pulmonary Embolism	6%
275	Mental Fatigue	6%
276	Hirsutism	6%
277	Orthostatic intolerance	6%
278	Pain, Postoperative	5.9%
279	Noonan Syndrome	5.9%
280	Body Weight Changes	5.9%
281	Sleep Apnea, Obstructive	5.9%
282	Sleep Apnea, Central	5.9%
283	Choanal Atresia	5.9%
284	Laryngocele	5.9%
285	Arteriovenous fistula	5.8%
286	Tracheal Neoplasms	5.8%
287	Vascular Remodeling	5.7%
288	Pleural Effusion, Malignant	5.6%
289	Sinusitis	5.6%
290	Bronchial Neoplasms	5.5%
291	Truncus Arteriosus, Persistent	5.4%
292	Aspergillosis, Allergic Bronchopulmonary	5.4%
293	Marfan Syndrome	5.4%
294	Subacute Bacterial Endocarditis	5.3%
295	Sleep Wake Disorders	5.3%
296	Aortic Aneurysm	5.3%
297	Aortitis	5.3%
298	Leriche Syndrome	5.3%
299	Periphlebitis	5.3%
300	Phlebitis	5.3%
301	Aspiration Pneumonia	5.3%
302	Thromboangiitis Obliterans	5.3%
303	Muscle Weakness	5.3%
304	Jaundice, Obstructive	5.2%
305	Pupil Disorders	5.2%
306	Neurobehavioral Manifestations	5.2%
307	Laryngeal neoplasm	5.1%
308	Nasal Polyps	5.1%
309	Aneurysm	5%
310	Angiomatosis	5%
311	Aortic Diseases	5%
312	Arterial Occlusive Diseases	5%
313	Atelectasis	5%
314	Bronchospasm	5%
315	Bronchiectasis	5%
316	Chylothorax	5%
317	Hydropneumothorax	5%
318	Hydrothorax	5%
319	Hyperemia	5%
320	Pulmonary Hypertension	5%
321	Hypotension	5%
322	Pneumothorax	5%
323	Pulmonary Alveolar Proteinosis	5%
324	Pulmonary Edema	5%
325	Pulmonary Fibrosis	5%
326	Superior Vena Cava Syndrome	5%
327	Telangiectasis	5%
328	Tracheal Stenosis	5%
329	Vasculitis	5%
330	Venous Insufficiency	5%
331	Vocal Cord Paralysis	5%
332	Peripheral Vascular Diseases	5%
333	Bronchial Hyperreactivity	5%
334	Embolism and Thrombosis	5%
335	Angiodysplasia	5%
336	Hamman-Rich syndrome	5%
337	Lung Diseases, Interstitial	5%
338	Capillary Leak Syndrome	5%
339	Lung Diseases, Obstructive	5%
340	Prehypertension	5%
341	Asterixis	5%
342	Ballismus	5%
343	Embolism, Amniotic Fluid	5%
344	Vertigo	5%
345	Primary Ciliary Dyskinesia	5%
346	Pain	5%
347	Ache	5%
348	Muscular Atrophy	4.9%
349	Oliguria	4.9%
350	Polyuria	4.9%
351	Proteinuria	4.9%
352	Back Pain	4.9%
353	Bulimia	4.9%
354	Neck Pain	4.9%
355	Chest Pain	4.9%
356	Dizziness	4.9%
357	Dysmenorrhea	4.9%
358	Dysuria	4.9%
359	Facial Pain	4.9%
360	Fever of Unknown Origin	4.9%
361	Flank Pain	4.9%
362	Headache	4.9%
363	Nocturia	4.9%
364	Pain, Intractable	4.9%
365	Pelvic Pain	4.9%
366	Chronic pain	4.9%
367	Lightheadedness	4.9%
368	Pain, Referred	4.9%
369	Prostatism	4.9%
370	Throbbing Headache	4.9%
371	Labor Pain	4.9%
372	Cancer Pain	4.9%
373	Failed Back Surgery Syndrome	4.9%
374	Nociceptive Pain	4.9%
375	Purpura, Hyperglobulinemic	4.9%
376	Gait Ataxia	4.9%
377	Underweight	4.9%
378	Overweight	4.9%
379	Retinal Vein Occlusion	4.8%
380	Aphonia	4.7%
381	Dysphonia	4.7%
382	Mediastinal Emphysema	4.6%
383	Thrombophlebitis	4.6%
384	Postphlebitic Syndrome	4.6%
385	Idiopathic Pulmonary Fibrosis	4.6%
386	Pneumoconiosis	4.6%
387	Pneumonia, Viral	4.6%
388	Phantom pain	4.5%
389	Phantom Limb Pain	4.5%
390	Pneumonia, Bacterial	4.5%
391	Malignant Atrophic Papulosis	4.4%
392	Shwartzman Phenomenon	4.4%
393	May-Thurner Syndrome	4.4%
394	Asthma, Exercise-Induced	4.4%
395	Status Asthmaticus	4.4%
396	Multiple Pulmonary Nodules	4.4%
397	Hematemesis	4.4%
398	Purpura Fulminans	4.3%
399	Gagging	4.3%
400	Akathisia	4.3%
401	Restlessness	4.3%
402	Psychomotor Agitation	4.3%
403	Pulmonary Infarction	4.3%
404	Aortic Rupture	4.2%
405	Ascites	4.2%
406	Calculi	4.2%
407	Fibrosis	4.2%
408	Gliosis	4.2%
409	Growth Disorders	4.2%
410	Hemorrhage	4.2%
411	Hernia	4.2%
412	Hyperbilirubinemia	4.2%
413	Hyperplasia	4.2%
414	Hypertrophy	4.2%
415	Hypomenorrhea	4.2%
416	Inflammation	4.2%
417	Intraoperative Complications	4.2%
418	Ischemia	4.2%
419	Lithiasis	4.2%
420	Malacoplakia	4.2%
421	Menstruation Disturbances	4.2%
422	Metaplasia	4.2%
423	Nails, Malformed	4.2%
424	Nerve Degeneration	4.2%
425	Ochronosis	4.2%
426	Polymenorrhea	4.2%
427	polyps	4.2%
428	Postoperative Complications	4.2%
429	Rupture, Spontaneous	4.2%
430	Sclerosis	4.2%
431	Shock	4.2%
432	Ulcer	4.2%
433	Enterocele	4.2%
434	Hyperammonemia	4.2%
435	Hyperamylasemia	4.2%
436	Teratogenesis	4.2%
437	Atheroma	4.2%
438	Cardiac Death	4.2%
439	Hypovolemia	4.2%
440	Hyperuricemia	4.2%
441	Leukoaraiosis	4.2%
442	Stenosis	4.2%
443	Facial asymmetry	4.2%
444	Dysbacteriosis	4.2%
445	Delayed Graft Function	4.2%
446	Cirrhosis	4.2%
447	Plaque, Amyloid	4.2%
448	Plaque, Atherosclerotic	4.2%
449	Neointima	4.2%
450	Dysbiosis	4.2%
451	Vascular System Injuries	4.2%
452	Blue Toe Syndrome	4.1%
453	Compartment syndromes	4.1%
454	Granuloma, Lethal Midline	4.1%
455	Hepatic Veno-Occlusive Disease	4.1%
456	Laryngeal Edema	4.1%
457	Nose Deformities, Acquired	4.1%
458	Peliosis Hepatis	4.1%
459	Varicocele	4.1%
460	Lung Injury	4.1%
461	Hepatopulmonary Syndrome	4.1%
462	Nose Neoplasms	4.1%
463	Cerebrovascular Disorders	4%
464	Common Cold	4%
465	Diabetic Angiopathies	4%
466	Influenza	4%
467	Splenic Infarction	4%
468	Cerebrovascular Insufficiency	4%
469	Vascular Neoplasms	4%
470	Spinal Cord Vascular Diseases	4%
471	Catarrh	4%
472	Rhinoscleroma	4%
473	Hemorrhoids	4%
474	Thoracic Outlet Syndrome	4%
475	Morning Sickness	4%
476	Pulmonary Eosinophilia	4%
477	Severe Acute Respiratory Syndrome	4%
478	Eosinophilic Pneumonia	4%
479	Laryngopharyngeal Reflux	4%
480	Infarction	4%
481	Postoperative Hemorrhage	4%
482	Shock, Hemorrhagic	4%
483	Systemic Inflammatory Response Syndrome	4%
484	Incisional hernia	4%
485	Paranasal Sinus Neoplasms	4%
486	Gait Apraxia	4%
487	Anosmia	3.9%
488	Ataxia	3.9%
489	Athetosis	3.9%
490	Catalepsy	3.9%
491	Dystonia	3.9%
492	Hemiplegia	3.9%
493	Locked-In Syndrome	3.9%
494	Muscle Hypertonia	3.9%
495	Muscle hypotonia	3.9%
496	Myoclonus	3.9%
497	Myotonia	3.9%
498	Neuralgia	3.9%
499	Paraplegia	3.9%
500	Pseudobulbar Palsy	3.9%
501	Quadriplegia	3.9%
502	Spasm	3.9%
503	Spastic Paraplegia	3.9%
504	Status Epilepticus	3.9%
505	Taste Disorders	3.9%
506	Tremor	3.9%
507	Monoplegia	3.9%
508	Hypokinesia	3.9%
509	Gastroparesis	3.9%
510	Paraparesis	3.9%
511	No-Reflow Phenomenon	3.9%
512	Bradykinesia	3.9%
513	Waxy flexibility	3.9%
514	Action Tremor	3.9%
515	Resting Tremor	3.9%
516	Dysosmia	3.9%
517	Quadriparesis	3.9%
518	Olfaction Disorders	3.9%
519	Myokymia	3.9%
520	Somatosensory Disorders	3.9%
521	Primary Graft Dysfunction	3.9%
522	Neuropathic pain	3.9%
523	Hyperkinesia	3.9%
524	Intention tremor	3.9%
525	Carotid Artery Thrombosis	3.9%
526	Pneumonia, Lipid	3.9%
527	Aortic Aneurysm, Abdominal	3.9%
528	Aortic Aneurysm, Thoracic	3.9%
529	Kearns-Sayre syndrome	3.9%
530	Weight Gain	3.9%
531	Asthma, Occupational	3.9%
532	Moyamoya Disease	3.9%
533	Intracranial Embolism and Thrombosis	3.8%
534	Carotid Stenosis	3.8%
535	Intracranial Aneurysm	3.8%
536	Radiation Pneumonitis	3.8%
537	Radiation Fibrosis	3.8%
538	Jet Lag Syndrome	3.7%
539	Reflex, Abnormal	3.7%
540	Hyporeflexia	3.7%
541	Hyperreflexia	3.7%
542	Emaciation	3.7%
543	Low Back Pain	3.7%
544	Visceral Pain	3.7%
545	Birth Weight	3.6%
546	Bronchiolitis Obliterans	3.6%
547	Granulomatosis with polyangiitis	3.6%
548	Sarcopenia	3.5%
549	Williams Syndrome	3.5%
550	Cyst	3.5%
551	Extravasation of Diagnostic and Therapeutic Materials	3.5%
552	Neoplastic Processes	3.5%
553	Hand-Arm Vibration Syndrome	3.5%
554	Pharyngitis	3.4%
555	Vision Disorders	3.4%
556	Metamorphopsia	3.4%
557	Visual Impairment	3.4%
558	Leukoplakia	3.4%
559	Necrosis	3.4%
560	Granulomatosis, Orofacial	3.4%
561	Pigmentation Disorders	3.4%
562	Airway Remodeling	3.4%
563	Laryngostenosis	3.4%
564	Optic Neuropathy, Ischemic	3.4%
565	Anterior Ischemic Optic Neuropathy	3.4%
566	Mesenteric vascular insufficiency	3.4%
567	Metatarsalgia	3.4%
568	Acantholysis	3.4%
569	Chromosome Aberrations	3.4%
570	Dehydration	3.4%
571	Granuloma	3.4%
572	Leukocytosis	3.4%
573	Pleocytosis	3.4%
574	Ventricular Remodeling	3.4%
575	Thrombocytopenic purpura	3.3%
576	Alopecia	3.3%
577	Anisocoria	3.3%
578	Confusion	3.3%
579	Facial paralysis	3.3%
580	Lethargy	3.3%
581	Memory Disorders	3.3%
582	Muscle Cramp	3.3%
583	Perceptual Disorders	3.3%
584	Psychomotor Disorders	3.3%
585	Tonic Pupil	3.3%
586	Pertussis	3.3%
587	Androgenetic Alopecia	3.3%
588	Anhedonia	3.3%
589	Disorientation	3.3%
590	Facial Paresis	3.3%
591	Memory Loss	3.3%
592	Hemisensory Neglect	3.3%
593	Vasculitis, Central Nervous System	3.3%
594	Dysacusis	3.3%
595	Asthma, Aspirin-Induced	3.3%
596	Angioedema	3.3%
597	Asbestosis	3.3%
598	Berylliosis	3.3%
599	Silicosis	3.3%
600	Farmer's Lung	3.3%
601	Aneurysm, Dissecting	3.3%
602	Arteriosclerosis	3.3%
603	Arteritis	3.3%
604	Embolism	3.3%
605	Epiglottitis	3.3%
606	Erythromelalgia	3.3%
607	Fibromuscular Dysplasia	3.3%
608	Malignant Hypertension	3.3%
609	Chronic Obstructive Airway Disease	3.3%
610	Mediastinitis	3.3%
611	Middle Lobe Syndrome	3.3%
612	Raynaud Disease	3.3%
613	Thromboembolism	3.3%
614	Thrombosis	3.3%
615	Essential Hypertension	3.3%
616	Colitis, Ischemic	3.3%
617	Aneurysm, Ruptured	3.3%
618	Iliac Aneurysm	3.3%
619	Pulmonary artery stenosis	3.3%
620	Acute Lung Injury	3.3%
621	White Coat Hypertension	3.3%
622	Systemic Vasculitis	3.3%
623	Embolus	3.3%
624	Mastodynia	3.3%
625	Chorea	3.3%
626	Polyarteritis Nodosa	3.3%
627	Takayasu Arteritis	3.3%
628	Tetany	3.3%
629	Urinary Incontinence	3.3%
630	Breakthrough Pain	3.3%
631	Hay fever	3.3%
632	Rhinitis, Allergic, Perennial	3.3%
633	Albuminuria	3.3%
634	Intracranial Arteriosclerosis	3.3%
635	Cerebral Atherosclerosis	3.3%
636	Hemoglobinuria	3.3%
637	Cerebral Arteriosclerosis	3.3%
638	Alice in Wonderland Syndrome	3.2%
639	Turner Syndrome	3.2%
640	Cachexia	3.1%
641	Alexia	3%
642	Dyslexia	3%
643	Toothache	3%
644	Cerebral Thrombosis	3%
645	Intracranial Embolism	3%
646	Intracranial Thrombosis	3%
647	Hydrops Fetalis	3%
648	Cystic Fibrosis	3%
649	Hyperemesis Gravidarum	3%
650	Giant Cell Arteritis	2.9%
651	Temporal Arteritis	2.9%
652	Fetal Weight	2.9%
653	Dysgeusia	2.9%
654	Formication	2.9%
655	Hyperalgesia	2.9%
656	Hyperesthesia	2.9%
657	Hypesthesia	2.9%
658	Language Disorders	2.9%
659	Numbness	2.9%
660	Paresthesia	2.9%
661	Paraparesis, Spastic	2.9%
662	Trismus	2.9%
663	Epilepsia Partialis Continua	2.9%
664	Hypogeusia	2.9%
665	Brown-Sequard Syndrome	2.9%
666	Lockjaw	2.9%
667	Allodynia	2.9%
668	Ageusia	2.9%
669	Blastomycosis	2.9%
670	Maxillary Sinus Neoplasms	2.9%
671	Genomic Instability	2.9%
672	Consciousness Disorders	2.9%
673	Mental Retardation	2.9%
674	Depressed Level of Consciousness	2.9%
675	Mental deficiency	2.9%
676	Intellectual Disability	2.9%
677	Catatonia	2.9%
678	Musculoskeletal Pain	2.9%
679	Ophthalmoplegia	2.9%
680	External Ophthalmoplegia	2.9%
681	Chromosomal Instability	2.9%
682	Arthralgia	2.8%
683	Sleep Deprivation	2.8%
684	Polyarthralgia	2.8%
685	Cerebrospinal Fluid Otorrhea	2.8%
686	Cerebrospinal Fluid Rhinorrhea	2.8%
687	Obesity	2.8%
688	Brain Infarction	2.8%
689	Diverticulum	2.8%
690	Diverticulosis	2.8%
691	Azotemia	2.8%
692	Menorrhagia	2.7%
693	Subarachnoid Hemorrhage	2.7%
694	Cerebral Hemorrhage	2.7%
695	Mediastinal Cyst	2.7%
696	Pericardial Cyst	2.7%
697	Persistent Fetal Circulation Syndrome	2.7%
698	Retinal Artery Occlusion	2.7%
699	Thymic Cyst	2.7%
700	Retinal Vasculitis	2.7%
701	Hypertensive Retinopathy	2.7%
702	Lemierre Syndrome	2.7%
703	Anterior Compartment Syndrome	2.6%
704	Croup	2.6%
705	Histiocytosis, Langerhans-Cell	2.6%
706	Rhinitis, Vasomotor	2.6%
707	Vasculitis, Leukocytoclastic, Cutaneous	2.6%
708	Gastric Antral Vascular Ectasia	2.6%
709	Abdominal Compartment Syndrome	2.6%
710	Pulmonary Aspergillosis	2.6%
711	Bronchopulmonary Aspergillosis	2.6%
712	Carotid Artery Diseases	2.6%
713	Brain Ischemia	2.6%
714	Ectopia Cordis	2.6%
715	Hypotension, Orthostatic	2.6%
716	Sarcoidosis, Pulmonary	2.6%
717	Cerebrovascular accident	2.6%
718	Varicose Ulcer	2.6%
719	Vasospasm, Intracranial	2.6%
720	Spinal Cord Ischemia	2.6%
721	Intracranial Arterial Diseases	2.6%
722	Single umbilical artery	2.6%
723	Post-Exercise Hypotension	2.6%
724	Sudden infant death syndrome	2.6%
725	Subarachnoid Hemorrhage, Traumatic	2.6%
726	Carotid Artery, Internal, Dissection	2.6%
727	Sinus Thrombosis, Intracranial	2.6%
728	Laryngomalacia	2.6%
729	CREST Syndrome	2.5%
730	Basal Ganglia Hemorrhage	2.5%
731	Infarction, Middle Cerebral Artery	2.5%
732	Infarction, Anterior Cerebral Artery	2.5%
733	Infarction, Posterior Cerebral Artery	2.5%
734	Acute Disease	2.5%
735	Acute-Phase Reaction	2.5%
736	Amenorrhea	2.5%
737	Chronic disease	2.5%
738	Critical Illness	2.5%
739	Sudden death	2.5%
740	Diplopia	2.5%
741	Eosinophilic Granuloma	2.5%
742	Fat necrosis	2.5%
743	Gangrene	2.5%
744	Graft Occlusion, Vascular	2.5%
745	Granuloma, Plasma Cell	2.5%
746	Hematoma	2.5%
747	Diaphragmatic Hernia	2.5%
748	Iatrogenic Disease	2.5%
749	Intestinal Polyps	2.5%
750	Multiple Organ Failure	2.5%
751	Muscle Rigidity	2.5%
752	Muscle Spasticity	2.5%
753	Oligomenorrhea	2.5%
754	Premenstrual syndrome	2.5%
755	Recurrence	2.5%
756	Retrograde Degeneration	2.5%
757	Retroperitoneal fibrosis	2.5%
758	Scotoma	2.5%
759	Serositis	2.5%
760	Splenomegaly	2.5%
761	Subcutaneous Emphysema	2.5%
762	Surgical Wound Dehiscence	2.5%
763	Syndrome	2.5%
764	Wallerian Degeneration	2.5%
765	Photophobia	2.5%
766	Pyogenic granuloma	2.5%
767	Cogwheel Rigidity	2.5%
768	Exsanguination	2.5%
769	Disease Progression	2.5%
770	Seroma	2.5%
771	Hemifacial Spasm	2.5%
772	Amaurosis	2.5%
773	Premenstrual Tension	2.5%
774	Blindness	2.5%
775	Delayed Emergence from Anesthesia	2.5%
776	Infant Death	2.5%
777	Anastomotic Leak	2.5%
778	Intraoperative Awareness	2.5%
779	Nuchal Rigidity	2.5%
780	Arteriosclerosis Obliterans	2.5%
781	Atherosclerosis	2.5%
782	Air Embolism	2.5%
783	Endarteritis	2.5%
784	Pulmonary Emphysema	2.5%
785	Venous Thrombosis	2.5%
786	Deep Vein Thrombosis	2.5%
787	Venous Thromboembolism	2.5%
788	Vertebral Artery Dissection	2.5%
789	Agnosia	2.5%
790	Apraxias	2.5%
791	Hallucinations	2.5%
792	Hemianopsia	2.5%
793	Hyperacusis	2.5%
794	Tinnitus	2.5%
795	Visual Agnosia	2.5%
796	Anosognosia	2.5%
797	Wernicke-Korsakoff Syndrome	2.5%
798	Phonophobia	2.5%
799	Hearing Loss	2.5%
800	Cerebellar Ataxia	2.4%
801	Torticollis	2.4%
802	Sciatica	2.4%
803	Urge Incontinence	2.4%
804	Tardive Dyskinesia	2.4%
805	Agraphia	2.4%
806	Anomia	2.4%
807	Cluttering	2.4%
808	Language Development Disorders	2.4%
809	Speech Disorders	2.4%
810	Syncope	2.4%
811	Stupor	2.4%
812	Dysgraphia	2.4%
813	Presyncope	2.4%
814	Dyslalia	2.4%
815	Tinea Pedis	2.4%
816	Cardiotoxicity	2.4%
817	Purpura, Thrombotic Thrombocytopenic	2.4%
818	Cavernous Sinus Thrombosis	2.3%
819	Sagittal Sinus Thrombosis	2.3%
820	Hematoma, Subdural	2.3%
821	Hematoma, Epidural, Cranial	2.3%
822	Cerebral Infarction	2.3%
823	Brain Stem Infarctions	2.3%
824	Mesenteric Vascular Occlusion	2.2%
825	Mucocutaneous Lymph Node Syndrome	2.2%
826	Dyskinesia, Drug-Induced	2.2%
827	Diabetic Retinopathy	2.2%
828	Sturge-Weber Syndrome	2.2%
829	Tonsillitis	2.2%
830	Renal hypertension	2.2%
831	Renal Artery Obstruction	2.2%
832	Renal Artery Stenosis	2.2%
833	Hemangioma, Cavernous	2.2%
834	Alcohol Withdrawal Seizures	2.2%
835	Basal Ganglia Cerebrovascular Disease	2.2%
836	Aphasia	2.2%
837	Articulation Disorders	2.2%
838	Echolalia	2.2%
839	Stuttering	2.2%
840	Dysphasia	2.2%
841	Vascular Headaches	2.2%
842	Scurvy	2.2%
843	Carotid Artery Injuries	2.2%
844	Waterhouse-Friderichsen Syndrome	2.2%
845	Putaminal Hemorrhage	2.1%
846	Amblyopia	2.1%
847	Amnesia	2.1%
848	Delirium	2.1%
849	Horner Syndrome	2.1%
850	Dissociative Amnesia	2.1%
851	Color blindness	2.1%
852	Global Amnesia	2.1%
853	Shoulder Pain	2.1%
854	Pediatric Obesity	2.1%
855	Asphyxia	2.1%
856	Shock, Traumatic	2.1%
857	Lateral Medullary Syndrome	2.1%
858	Dysarthria	2.1%
859	Amaurosis Fugax	2%
860	Blindness, Cortical	2%
861	Dyscalculia	2%
862	Deafness	2%
863	Hearing Loss, Sudden	2%
864	Gerstmann Syndrome	2%
865	Hearing Loss, Bilateral	2%
866	Hearing Loss, High-Frequency	2%
867	Hearing Loss, Mixed Conductive-Sensorineural	2%
868	Prosopagnosia	2%
869	Apraxia, Ideomotor	2%
870	Persistent Vegetative State	2%
871	Charles Bonnet Syndrome	2%
872	Hearing Loss, Unilateral	2%
873	Complete Hearing Loss	2%
874	Alien Hand Syndrome	2%
875	Deaf Mutism	2%
876	Disease susceptibility	2%
877	Fetal Death	2%
878	Foreign-Body Reaction	2%
879	Gastrointestinal Hemorrhage	2%
880	Hemarthrosis	2%
881	Hemoperitoneum	2%
882	Hepatomegaly	2%
883	Neoplasm Invasiveness	2%
884	Neoplasm Metastasis	2%
885	Neoplasm Recurrence, Local	2%
886	Parovarian Cyst	2%
887	Prosthesis Failure	2%
888	Spermatocele	2%
889	Oral Fistula	2%
890	Injection Site Reaction	2%
891	Retrobulbar Hemorrhage	2%
892	Cutaneous Fistula	2%
893	Aseptic Necrosis of Bone	2%
894	Peritoneal Fibrosis	2%
895	Carcinogenesis	2%
896	Neurogenic Inflammation	2%
897	Perinatal death	2%
898	Infusion site reaction	2%
899	Nephrogenic Fibrosing Dermopathy	2%
900	Corneal Endothelial Cell Loss	2%
901	Encapsulating Peritoneal Sclerosis	2%
902	Suppuration	2%
903	Nephrogenic Systemic Fibrosis	2%
904	Metastasis	2%
905	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	2%
906	Dental Pulp Necrosis	2%
907	Granuloma, Foreign-Body	2%
908	Surgical Wound Infection	2%
909	Facies	2%
910	Embryo Loss	2%
911	Autoimmune thrombocytopenia	2%
912	Immune thrombocytopenic purpura	2%
913	Afferent Loop Syndrome	2%
914	Bronchopulmonary Dysplasia	2%
915	Sex Chromosome Aberrations	2%
916	Short Bowel Syndrome	2%
917	Uterine hemorrhage	2%
918	Vaginal Fistula	2%
919	Rectocele	2%
920	Cerebral Arterial Diseases	2%
921	Vertebrobasilar Insufficiency	2%
922	Anterior Spinal Artery Syndrome	2%
923	Basilar Artery Stenosis	2%
924	Vertebral Artery Stenosis	2%
925	Intracranial Hemorrhage, Hypertensive	2%
926	Transient Cerebral Ischemia	2%
927	Endotoxic shock	1.9%
928	Septic Shock	1.9%
929	Toxic Shock Syndrome	1.9%
930	Dural Arteriovenous Fistula	1.9%
931	Ischemic contracture	1.9%
932	Angioedemas, Hereditary	1.9%
933	Retropharyngeal Abscess	1.9%
934	Akathisia, Drug-Induced	1.9%
935	Anti-Glomerular Basement Membrane Disease	1.9%
936	Cryoglobulinemia	1.9%
937	Leukomalacia, Periventricular	1.9%
938	Bronchomalacia	1.9%
939	Tracheomalacia	1.9%
940	Hematoma, Subdural, Intracranial	1.9%
941	Hematoma, Subdural, Chronic	1.9%
942	Hematoma, Subdural, Acute	1.9%
943	Chromosome Fragility	1.9%
944	Diabetic Foot	1.9%
945	Myalgia	1.9%
946	Mutism	1.8%
947	Selective Mutism	1.8%
948	Retrograde amnesia	1.7%
949	Amnesia, Anterograde	1.7%
950	Alexia, Pure	1.7%
951	Drowning	1.7%
952	Fetal Growth Retardation	1.7%
953	DNA Degradation, Necrotic	1.7%
954	Aneuploidy	1.7%
955	Polyploidy	1.7%
956	Microsatellite Instability	1.7%
957	Transfusion-Related Acute Lung Injury	1.7%
958	Hepatic Vein Thrombosis	1.7%
959	Budd-Chiari Syndrome	1.7%
960	Nasopharyngitis	1.7%
961	Cicatrix	1.7%
962	Hematuria	1.6%
963	Meningocele	1.6%
964	Urinary Calculi	1.6%
965	Granuloma Annulare	1.6%
966	Chromosome Breakage	1.6%
967	Encephalocele	1.6%
968	Brain Death	1.6%
969	Tissue Adhesions	1.6%
970	Colonic Polyps	1.6%
971	Invasive Pulmonary Aspergillosis	1.6%
972	Hematoma, Epidural, Spinal	1.6%
973	Shy-Drager Syndrome	1.6%
974	Auditory Perceptual Disorders	1.6%
975	Hypertension, Renovascular	1.6%
976	Trisomy	1.6%
977	Hypoxia-Ischemia, Brain	1.6%
978	Subclavian Steal Syndrome	1.6%
979	Dementia, Vascular	1.6%
980	Hereditary Angioedema Type III	1.6%
981	Hereditary Angioedema Types I and II	1.6%
982	Amnesia, Transient Global	1.5%
983	Ophthalmoplegic Migraine	1.5%
984	Behcet Syndrome	1.5%
985	Progressive supranuclear palsy	1.5%
986	Waldenstrom Macroglobulinemia	1.5%
987	Multiple Myeloma	1.5%
988	Giant Cell Epulis	1.4%
989	Leukoplakia, Oral	1.4%
990	Vesicovaginal Fistula	1.4%
991	Pituitary Apoplexy	1.4%
992	Micronuclei, Chromosome-Defective	1.4%
993	Peritonsillar Abscess	1.4%
994	Lupus Vasculitis, Central Nervous System	1.4%
995	Cerebral Amyloid Angiopathy	1.3%
996	Ataxia Telangiectasia	1.3%
997	Biliary Fistula	1.3%
998	Cross Infection	1.3%
999	Gastric Fistula	1.3%
1000	Hyphema	1.3%
1001	Pseudoxanthoma Elasticum	1.3%
1002	Retinal Neovascularization	1.3%
1003	Septicemia	1.3%
1004	Vitreous Hemorrhage	1.3%
1005	Congenital diaphragmatic hernia	1.3%
1006	Sepsis	1.3%
1007	Abscess	1.3%
1008	Dental Fistula	1.3%
1009	Empyema	1.3%
1010	Femur Head Necrosis	1.3%
1011	Fetal Resorption	1.3%
1012	Lymphatic Metastasis	1.3%
1013	Neoplasms, Unknown Primary	1.3%
1014	Oroantral Fistula	1.3%
1015	Peptic Ulcer Hemorrhage	1.3%
1016	Leukemic Infiltration	1.3%
1017	Premenstrual Dysphoric Disorder	1.3%
1018	Choroidal Neovascularization	1.3%
1019	Neoplasm Micrometastasis	1.3%
1020	Dumping Syndrome	1.3%
1021	Rectal Prolapse	1.3%
1022	Uterine Prolapse	1.3%
1023	Cicatrix, Hypertrophic	1.3%
1024	Vaginal Prolapse	1.3%
1025	Metrorrhagia	1.3%
1026	Subacute Combined Degeneration	1.3%
1027	Rheumatoid Vasculitis	1.2%
1028	Hematoma, Subdural, Spinal	1.2%
1029	Pancreatic Fistula	1.1%
1030	Retinal Hemorrhage	1.1%
1031	Choroid Hemorrhage	1.1%
1032	Intestinal Fistula	1.1%
1033	Kernicterus	1.1%
1034	Melena	1.1%
1035	Gastroschisis	1.1%
1036	Enterocutaneous Fistula	1.1%
1037	Postpartum Hemorrhage	1.1%
1038	Salivary Gland Fistula	1.1%
1039	Cystocele	1.1%
1040	Gingival Hemorrhage	1.1%
1041	Keloid	1.1%
1042	Monosomy	1.1%
1043	Tetraploidy	1.1%
1044	Stillbirth	1.1%
1045	Viremia	1%
1046	Parasitemia	1%
1047	Umbilical hernia	1%
1048	Cellulitis	1%
1049	Bacteremia	0.8%
1050	Cell Transformation, Viral	0.8%
1051	Fungemia	0.8%
1052	Urinary Bladder Fistula	0.8%
1053	Brain Hemorrhage, Traumatic	0.8%
1054	MELAS Syndrome	0.8%
1055	Philadelphia Chromosome	0.7%
1056	Rectal Fistula	0.7%
1057	Anal Fistula	0.7%
1058	Endotoxemia	0.7%
1059	Kidney Calculi	0.6%
1060	Ureteral Calculi	0.6%
1061	Fabry Disease	0.6%
1062	Candidemia	0.5%

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