MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

CREST Syndrome

(UMLS:C0206138)

Definition:: A mild form of LIMITED SCLERODERMA, a multi-system disorder. Its features include symptoms of CALCINOSIS; RAYNAUD DISEASE; ESOPHAGEAL MOTILITY DISORDERS; sclerodactyly, and TELANGIECTASIS. When the defect in esophageal function is not prominent, it is known as CRST syndrome.
UMLS ID:: C0206138
MeSH ID:: D017675

Classification 1:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.405.117.119.500.204

Classification 2:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.617.812.500|C14.907.823.225

Classification 3:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.300.799.801.500|C17.800.784.801.500

Classification 4:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.174.130.204

Synonym(s)

CREST Syndrome

CR(E)ST syndrome

CREST

CREST - Calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, telangiectasia

CREST - Calcinosis, Raynaud's phenomenon, oesophageal dysfunction, sclerodactyly, telangiectasia

CREST - Calcinosis, Raynaud's phenomenon, sclerodactyly, esophageal involvement, telangiectasia syndrome

CREST - Calcinosis, Raynaud's phenomenon, sclerodactyly, oesophageal involvement, telangiectasia syndrome

CREST SYNDROME

CREST VARIANT OF SCLERODERMA

10.

CREST syndrome

11.

Calcinosis cutis, Raynaud's, esophageal dysfunction, sclerodactyly AND telangiectasia

12.

Calcinosis cutis, Raynaud's, esophageal dysfunction, sclerodactyly and telangiectasia

13.

Calcinosis cutis, Raynaud's, oesophageal dysfunction, sclerodactyly and telangiectasia

14.

Calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia (CREST) syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Bosentan	FAERS: 7		US FAERS
2	Alendronate	FAERS: 5		US FAERS
3	Omeprazole	FAERS: 5		US FAERS
4	ambrisentan	FAERS: 5		US FAERS
5	macitentan	FAERS: 3		US FAERS
6	Lansoprazole	FAERS: 2		US FAERS
7	Norgestrel	FAERS: 2		OFFSIDES US FAERS
8	Teriparatide	FAERS: 2		US FAERS
9	rofecoxib	FAERS: 2		US FAERS
10	Bisacodyl	FAERS: 1		US FAERS
11	Fingolimod Hydrochloride	FAERS: 1		US FAERS
12	Metoclopramide	FAERS: 1		US FAERS
13	Midazolam	FAERS: 1		US FAERS
14	Penicillamine	FAERS: 1		US FAERS
15	Pregabalin	FAERS: 1		US FAERS
16	Raloxifene Hydrochloride	FAERS: 1		US FAERS
17	Rifaximin	FAERS: 1		US FAERS
18	Rivaroxaban	FAERS: 1		US FAERS
19	Ticagrelor	FAERS: 1		US FAERS
20	exemestane	FAERS: 1		US FAERS
21	obeticholic acid	FAERS: 1		US FAERS
22	reviparin	FAERS: 1		US FAERS
23	teriflunomide	FAERS: 1		US FAERS
24	treprostinil	FAERS: 1		US FAERS
25	Allopurinol			OFFSIDES
26	Atovaquone			OFFSIDES
27	Calcium Citrate			OFFSIDES
28	Cefoxitin			OFFSIDES
29	Ciprofloxacin			OFFSIDES
30	Cortisone			OFFSIDES
31	Econazole			OFFSIDES
32	Ertapenem			OFFSIDES
33	Erythromycin			OFFSIDES
34	Iloprost			OFFSIDES
35	Linezolid			OFFSIDES
36	Meperidine			OFFSIDES
37	Methotrexate		17400583	CTD
38	Moxifloxacin			OFFSIDES
39	Pamidronate			OFFSIDES
40	Raloxifene Hydrochloride			OFFSIDES
41	anagrelide			OFFSIDES
42	cefuroxime axetil			OFFSIDES
43	valdecoxib			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Periphlebitis	22%
2	Phlebitis	22%
3	Malignant Atrophic Papulosis	19.6%
4	Myocardial Ischemia	18.2%
5	Thrombophlebitis	17.9%
6	Postphlebitic Syndrome	17.8%
7	Blue Toe Syndrome	17.6%
8	Aortic Aneurysm	17.1%
9	Aortitis	17.1%
10	Leriche Syndrome	17.1%
11	Thromboangiitis Obliterans	17.1%
12	Myocardial Reperfusion Injury	16.6%
13	Mesenteric vascular insufficiency	16.6%
14	Lupus Erythematosus, Cutaneous	16.6%
15	Panniculitis	16.6%
16	Morphea	16.6%
17	Retinal Vein Occlusion	16.5%
18	Pseudoxanthoma Elasticum	16.5%
19	Livedo Reticularis	16.3%
20	Hepatic Veno-Occlusive Disease	15.5%
21	Peliosis Hepatis	15.5%
22	Aneurysm	15.5%
23	Angiomatosis	15.5%
24	Aortic Diseases	15.5%
25	Arterial Occlusive Diseases	15.5%
26	Hyperemia	15.5%
27	Hypotension	15.5%
28	Superior Vena Cava Syndrome	15.5%
29	Vasculitis	15.5%
30	Venous Insufficiency	15.5%
31	Embolism and Thrombosis	15.5%
32	Angiodysplasia	15.5%
33	Capillary Leak Syndrome	15.5%
34	Prehypertension	15.5%
35	Hemorrhoids	15.3%
36	Erythromelalgia	15.3%
37	Shwartzman Phenomenon	15.2%
38	Polyarteritis Nodosa	15.1%
39	Takayasu Arteritis	15.1%
40	Angioedema	14.9%
41	Coronary Aneurysm	14.8%
42	Aortic Rupture	14.7%
43	Colitis, Ischemic	14.7%
44	May-Thurner Syndrome	14.5%
45	Esophageal Achalasia	14.3%
46	Giant Cell Arteritis	14.2%
47	Temporal Arteritis	14.2%
48	Moyamoya Disease	14.1%
49	Arteriovenous fistula	14.1%
50	Vascular System Injuries	13.9%
51	Calciphylaxis	13.9%
52	Vascular calcification	13.9%
53	Compartment syndromes	13.7%
54	Varicocele	13.7%
55	Cerebrovascular Disorders	13.6%
56	Diabetic Angiopathies	13.6%
57	Reperfusion Injury	13.6%
58	Splenic Infarction	13.6%
59	Cerebrovascular Insufficiency	13.6%
60	Vascular Neoplasms	13.6%
61	Spinal Cord Vascular Diseases	13.6%
62	Vasoplegia	13.6%
63	Carotid Artery Thrombosis	13.5%
64	Thoracic Outlet Syndrome	13.5%
65	Xeroderma Pigmentosum	13.5%
66	Necrobiosis Lipoidica Diabeticorum	13.4%
67	Dermatomyositis	13.2%
68	Pyoderma Gangrenosum	13.1%
69	Panniculitis, Lupus Erythematosus	13%
70	Intracranial Embolism and Thrombosis	13%
71	Carotid Stenosis	12.9%
72	Intracranial Aneurysm	12.9%
73	Coronary Thrombosis	12.6%
74	Coronary Artery Disease	12.6%
75	Vasculitis, Central Nervous System	12.6%
76	Hand-Arm Vibration Syndrome	12.3%
77	Hypercalcemia	12.2%
78	Hypocalcemia	12.2%
79	Milk-Alkali Syndrome	12.2%
80	Optic Neuropathy, Ischemic	12.2%
81	Anterior Ischemic Optic Neuropathy	12.2%
82	Aortic Aneurysm, Abdominal	12.1%
83	Aortic Aneurysm, Thoracic	12.1%
84	Mesenteric Vascular Occlusion	12.1%
85	Mucocutaneous Lymph Node Syndrome	12.1%
86	Lipomatosis	11.9%
87	Varicose Ulcer	11.8%
88	Ataxia Telangiectasia	11.7%
89	Cutis Laxa	11.7%
90	Gastric Antral Vascular Ectasia	11.6%
91	Coronary heart disease	11.4%
92	Myocardial Infarction	11.4%
93	Acute Coronary Syndrome	11.4%
94	Behcet Syndrome	11.2%
95	Scimitar Syndrome	11.1%
96	Lemierre Syndrome	11%
97	Lipodystrophy	10.9%
98	Nephrocalcinosis	10.8%
99	Intracranial Arteriosclerosis	10.8%
100	Cerebral Atherosclerosis	10.8%
101	Cerebral Arteriosclerosis	10.8%
102	Dermatitis, Atopic	10.7%
103	Epidermolysis Bullosa	10.7%
104	Pseudohypoparathyroidism	10.7%
105	Erythema Induratum	10.5%
106	Kounis Syndrome	10.2%
107	Esophagitis	10.2%
108	Rickets	10.2%
109	Angina Pectoris	10.1%
110	Acne Vulgaris	9.8%
111	Contact Dermatitis	9.8%
112	Eczema	9.8%
113	Erythema Multiforme	9.8%
114	Intertrigo	9.8%
115	Lupus Erythematosus, Discoid	9.8%
116	Neurodermatitis	9.8%
117	Rhinophyma	9.8%
118	Perioral Dermatitis	9.8%
119	Acne	9.8%
120	Aneurysm, Dissecting	9.7%
121	Arteriosclerosis	9.7%
122	Arteritis	9.7%
123	Embolism	9.7%
124	Fibromuscular Dysplasia	9.7%
125	Malignant Hypertension	9.7%
126	Thromboembolism	9.7%
127	Thrombosis	9.7%
128	Essential Hypertension	9.7%
129	Aneurysm, Ruptured	9.7%
130	Iliac Aneurysm	9.7%
131	Pulmonary artery stenosis	9.7%
132	White Coat Hypertension	9.7%
133	Systemic Vasculitis	9.7%
134	Embolus	9.7%
135	Brain Infarction	9.7%
136	Cerebral Thrombosis	9.7%
137	Intracranial Embolism	9.7%
138	Intracranial Thrombosis	9.7%
139	Subarachnoid Hemorrhage, Traumatic	9.6%
140	Carotid Artery, Internal, Dissection	9.6%
141	Laryngopharyngeal Reflux	9.5%
142	Embolism, Amniotic Fluid	9.5%
143	Breast Diseases	9.4%
144	Collagen Diseases	9.4%
145	Dermatitis	9.4%
146	Exanthema	9.4%
147	Facial Dermatoses	9.4%
148	Hair Diseases	9.4%
149	Hand Dermatoses	9.4%
150	keratoacanthoma	9.4%
151	Keratosis	9.4%
152	Mixed Connective Tissue Disease	9.4%
153	Nail Diseases	9.4%
154	Photosensitivity Disorders	9.4%
155	Prurigo	9.4%
156	Pyoderma	9.4%
157	Rosacea	9.4%
158	Sebaceous Gland Diseases	9.4%
159	Skin Diseases, Vesiculobullous	9.4%
160	Skin Ulcer	9.4%
161	Sweat Gland Diseases	9.4%
162	Skin Diseases, Papulosquamous	9.4%
163	Skin Diseases, Vascular	9.4%
164	Mucinoses	9.4%
165	Acneiform Eruptions	9.4%
166	Ocular Rosacea	9.4%
167	Subcorneal pustular dermatosis	9.4%
168	Erythematotelangiectatic Rosacea	9.4%
169	Papulopustular Rosacea	9.4%
170	Chronic Actinic Dermatitis	9.4%
171	Noonan Syndrome	9.3%
172	Homocystinuria	9.1%
173	Heart Diseases	9.1%
174	Vertebral Artery Dissection	8.8%
175	Angioedemas, Hereditary	8.8%
176	Infarction, Middle Cerebral Artery	8.8%
177	Infarction, Anterior Cerebral Artery	8.8%
178	Infarction, Posterior Cerebral Artery	8.8%
179	Dermatitis Herpetiformis	8.8%
180	Diabetic Foot	8.7%
181	Acrodermatitis	8.7%
182	Sebaceous Gland Neoplasms	8.7%
183	Porokeratosis	8.7%
184	Gianotti-Crosti Syndrome	8.7%
185	Keratoderma, Palmoplantar	8.7%
186	Marfan Syndrome	8.7%
187	Retinal Artery Occlusion	8.6%
188	Retinal Vasculitis	8.6%
189	Hypertensive Retinopathy	8.6%
190	Dermatitis, Phototoxic	8.6%
191	Pityriasis Lichenoides et Varioliformis Acuta	8.6%
192	Pityriasis Lichenoides	8.6%
193	Phototoxicity	8.6%
194	Anterior Compartment Syndrome	8.6%
195	Vasculitis, Leukocytoclastic, Cutaneous	8.6%
196	Abdominal Compartment Syndrome	8.6%
197	Carotid Artery Diseases	8.5%
198	Brain Ischemia	8.5%
199	Hypotension, Orthostatic	8.5%
200	Cerebrovascular accident	8.5%
201	Vasospasm, Intracranial	8.5%
202	Spinal Cord Ischemia	8.5%
203	Intracranial Arterial Diseases	8.5%
204	Primary Graft Dysfunction	8.5%
205	Post-Exercise Hypotension	8.5%
206	Peripheral Vascular Diseases	8.4%
207	Cartilage Diseases	8.4%
208	Foot Diseases	8.4%
209	Rheumatism	8.4%
210	Chondromalacia	8.4%
211	Porphyrias, Hepatic	8.4%
212	Sjogren-Larsson Syndrome	8.3%
213	Lupus Erythematosus, Systemic	8.3%
214	Skin Abnormalities	8.3%
215	Skin Diseases, Infectious	8.3%
216	Skin Neoplasms	8.3%
217	Wasting Syndrome	8.3%
218	Overlap syndrome	8.3%
219	Pigmentation Disorders	8.3%
220	Pruritus	8.2%
221	Erythema	8.2%
222	Necrolytic Migratory Erythema	8.2%
223	Cutaneous Fistula	8.2%
224	Nephrogenic Fibrosing Dermopathy	8.2%
225	Nephrogenic Systemic Fibrosis	8.2%
226	Esophageal Neoplasms	8.2%
227	Zollinger-Ellison syndrome	8.2%
228	Esophageal and Gastric Varices	8.1%
229	Esophageal Stenosis	8.1%
230	Foot Ulcer	8.1%
231	Carotid Artery Injuries	8.1%
232	Coronary Occlusion	8.1%
233	Microvascular Angina	8.1%
234	Coronary Stenosis	8.1%
235	ST segment elevation myocardial infarction	8.1%
236	Esophageal Atresia	8%
237	Sinus Thrombosis, Intracranial	8%
238	Pregnancy Complications, Cardiovascular	8%
239	Cardiovascular Abnormalities	8%
240	Lupus Vasculitis, Central Nervous System	8%
241	Scurvy	8%
242	Xeroderma	7.9%
243	Dermatitis, Photoallergic	7.8%
244	Cerebral Infarction	7.7%
245	Brain Stem Infarctions	7.7%
246	Diabetic Retinopathy	7.7%
247	Sturge-Weber Syndrome	7.7%
248	Renal hypertension	7.6%
249	Renal Artery Obstruction	7.6%
250	Renal Artery Stenosis	7.6%
251	Hemangioma, Cavernous	7.6%
252	Basal Ganglia Cerebrovascular Disease	7.6%
253	Vascular Headaches	7.6%
254	Ichthyosis, X-Linked	7.4%
255	Esophageal Perforation	7.3%
256	Adiposis Dolorosa	7.3%
257	Mastocytosis	7.3%
258	Dupuytren Contracture	7.3%
259	Granuloma Annulare	7.2%
260	Basal Ganglia Hemorrhage	7.2%
261	Shock, Cardiogenic	7.2%
262	Cavernous Sinus Thrombosis	7.2%
263	Sagittal Sinus Thrombosis	7.2%
264	Urticaria Pigmentosa	7.2%
265	Barrett Esophagus	7.2%
266	Angina, Unstable	7.2%
267	Ectodermal Dysplasia	7.2%
268	Aplasia Cutis Congenita	7.2%
269	Hereditary Angioedema Type III	7.1%
270	Hereditary Angioedema Types I and II	7.1%
271	Acid-Base Imbalance	7%
272	Iron Metabolism Disorders	7%
273	Phosphorus Metabolism Disorders	7%
274	Telangiectasis	7%
275	Water-Electrolyte Imbalance	7%
276	Lipid Metabolism Disorders	7%
277	Mitochondrial Diseases	7%
278	Glucose Metabolism Disorders	7%
279	Arteriosclerosis Obliterans	6.9%
280	Atherosclerosis	6.9%
281	Air Embolism	6.9%
282	Endarteritis	6.9%
283	Venous Thrombosis	6.9%
284	Deep Vein Thrombosis	6.9%
285	Venous Thromboembolism	6.9%
286	Ischemic contracture	6.9%
287	Tricuspid Atresia	6.9%
288	Arrhythmogenic Right Ventricular Dysplasia	6.9%
289	Cryoglobulinemia	6.8%
290	Leukomalacia, Periventricular	6.8%
291	Osteomalacia	6.8%
292	Rheumatoid Vasculitis	6.8%
293	Mesenteric Panniculitis	6.8%
294	Panniculitis, Peritoneal	6.8%
295	MELAS Syndrome	6.8%
296	Hepatic Vein Thrombosis	6.7%
297	Budd-Chiari Syndrome	6.7%
298	Achlorhydria	6.7%
299	Lateral Medullary Syndrome	6.7%
300	Gastrointestinal Neoplasms	6.6%
301	Cellulitis	6.6%
302	Erythema Infectiosum	6.6%
303	Albinism	6.6%
304	Exanthema Subitum	6.5%
305	Erythema Nodosum	6.5%
306	Toxic Epidermal Necrolysis	6.5%
307	Stevens-Johnson Syndrome	6.5%
308	Dermatitis, Irritant	6.5%
309	Acne Conglobata	6.5%
310	Coronary Restenosis	6.4%
311	Cerebral Amyloid Angiopathy	6.4%
312	Leigh Disease	6.3%
313	Gastroenteritis	6.3%
314	Intestinal Diseases	6.3%
315	Stomach Diseases	6.3%
316	Lactose Intolerance	6.3%
317	Osteopenia	6.2%
318	Shy-Drager Syndrome	6.2%
319	Purpura, Hyperglobulinemic	6.2%
320	Brain Diseases, Metabolic	6.2%
321	Intermittent Claudication	6.1%
322	Pulmonary Embolism	6.1%
323	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	6.1%
324	Fabry Disease	6.1%
325	Dysentery	6.1%
326	Enteritis	6.1%
327	Enterocolitis	6.1%
328	Gastritis	6.1%
329	Inflammatory Bowel Diseases	6.1%
330	No-Reflow Phenomenon	6.1%
331	Pruritus Ani	6.1%
332	Menkes Kinky Hair Syndrome	6.1%
333	Cerebral Arterial Diseases	6%
334	Vertebrobasilar Insufficiency	6%
335	Anterior Spinal Artery Syndrome	6%
336	Basilar Artery Stenosis	6%
337	Vertebral Artery Stenosis	6%
338	Intracranial Hemorrhage, Hypertensive	6%
339	Transient Cerebral Ischemia	6%
340	Familial Hypophosphatemic Rickets	6%
341	Putaminal Hemorrhage	6%
342	Bacterial Endocarditis	6%
343	Dementia, Vascular	6%
344	CREST Syndrome	5.9%
345	Ecthyma	5.9%
346	Dermatitis, Occupational	5.9%
347	Brain Diseases, Metabolic, Inborn	5.9%
348	Tinea Capitis	5.8%
349	Onychomycosis	5.8%
350	Dermatitis, Allergic Contact	5.8%
351	Papillon-Lefevre Disease	5.7%
352	Waldenstrom Macroglobulinemia	5.7%
353	Multiple Myeloma	5.7%
354	Intestinal Neoplasms	5.7%
355	Stomach Neoplasms	5.7%
356	Angina Pectoris, Variant	5.7%
357	Aortic Valve Stenosis	5.7%
358	Cardiomyopathy, Dilated	5.7%
359	Pulmonary Valve Stenosis	5.7%
360	Anhidrosis	5.6%
361	Cholesteatoma	5.6%
362	Pressure Ulcer	5.6%
363	Folliculitis	5.6%
364	Foot Dermatoses	5.6%
365	Gynecomastia	5.6%
366	Hypertrichosis	5.6%
367	Hypohidrosis	5.6%
368	Hypotrichosis	5.6%
369	Leg Ulcer	5.6%
370	Miliaria	5.6%
371	Parakeratosis	5.6%
372	Parapsoriasis	5.6%
373	Pityriasis	5.6%
374	Psoriasis	5.6%
375	Raynaud Disease	5.6%
376	Sweet Syndrome	5.6%
377	Hidradenitis	5.6%
378	Onycholysis	5.6%
379	Miliaria Rubra	5.6%
380	Hyperpigmentation	5.6%
381	Lichenoid Eruptions	5.6%
382	Scleromyxedema	5.6%
383	Chloracne	5.6%
384	Carbamoyl-Phosphate Synthase I Deficiency Disease	5.6%
385	Gastrointestinal Hemorrhage	5.5%
386	Tuberculosis, Gastrointestinal	5.5%
387	Celiac Disease	5.5%
388	Sprue, Tropical	5.5%
389	Steatorrhea	5.5%
390	Sprue	5.5%
391	Congenital Hyperinsulinism	5.4%
392	HIV-Associated Lipodystrophy Syndrome	5.4%
393	Hypertension, Renovascular	5.4%
394	Subarachnoid Hemorrhage	5.4%
395	Hypoxia-Ischemia, Brain	5.4%
396	Cerebral Hemorrhage	5.4%
397	Hyperkeratosis, Epidermolytic	5.4%
398	Variegate Porphyria	5.3%
399	Acute intermittent porphyria	5.3%
400	Porphyria Cutanea Tarda	5.3%
401	Proctocolitis	5.3%
402	Hyperhomocysteinemia	5.3%
403	Renal Osteodystrophy	5.3%
404	Renal rickets	5.3%
405	Colorectal Neoplasms	5.2%
406	Cardiac Tamponade	5.2%
407	Endocarditis	5.2%
408	Cardiac Arrest	5.2%
409	Heart failure	5.2%
410	Pericardial effusion	5.2%
411	Pericarditis	5.2%
412	Pneumopericardium	5.2%
413	Cor pulmonale	5.2%
414	Ventricular Outflow Obstruction	5.2%
415	Ventricular Dysfunction	5.2%
416	Cardiomyopathies	5.2%
417	Pleuropericarditis	5.2%
418	Heart Block	5.1%
419	Tachycardia	5.1%
420	Tachyarrhythmia	5.1%
421	Aortic coarctation	5.1%
422	Cor Triatriatum	5.1%
423	Coronary Vessel Anomalies	5.1%
424	Patent ductus arteriosus	5.1%
425	Ebstein Anomaly	5.1%
426	Heart Septal Defects	5.1%
427	Tetralogy of Fallot	5.1%
428	Transposition of Great Vessels	5.1%
429	Hypoplastic Left Heart Syndrome	5.1%
430	Tetany	5%
431	Erythema Chronicum Migrans	5%
432	Mucopolysaccharidosis III	5%
433	Acantholysis	4.9%
434	Breast Cyst	4.9%
435	Actinic keratosis	4.9%
436	Pemphigoid, Benign Mucous Membrane	4.9%
437	Pemphigus	4.9%
438	Piedra	4.9%
439	Sunburn	4.9%
440	Tietze's Syndrome	4.9%
441	Orbital Cellulitis	4.9%
442	Myxoid cyst	4.9%
443	Argyria	4.9%
444	Hirsutism	4.9%
445	Lactation Disorder	4.9%
446	Mastitis	4.9%
447	Myxedema	4.9%
448	Urticaria	4.9%
449	Pituitary Apoplexy	4.9%
450	Colitis	4.9%
451	Duodenogastric Reflux	4.9%
452	Peptic Ulcer	4.9%
453	Proctitis	4.9%
454	Pruritus Vulvae	4.9%
455	Mastocytoma	4.9%
456	Pulmonary Infarction	4.9%
457	Smith-Lemli-Opitz Syndrome	4.9%
458	Mallory-Weiss Syndrome	4.8%
459	Duodenitis	4.8%
460	Ileitis	4.8%
461	Erosive Duodenitis	4.8%
462	Galactosemias	4.8%
463	Urea Cycle Disorders, Inborn	4.8%
464	Tyrosinemias	4.8%
465	Diaper Rash	4.8%
466	Subclavian Steal Syndrome	4.8%
467	Hidradenitis Suppurativa	4.7%
468	Zellweger Syndrome	4.6%
469	Dextrocardia	4.6%
470	Long QT Syndrome	4.6%
471	Cardiac Output, High	4.6%
472	Myocardial Stunning	4.6%
473	Low Cardiac Output Syndrome	4.6%
474	Cardiomegaly	4.5%
475	Postpericardiotomy Syndrome	4.5%
476	Cardiac Hypertrophy	4.5%
477	Rheumatic Heart Disease	4.5%
478	Hyperphosphaturia	4.5%
479	Hypertrophic Cardiomyopathy	4.5%
480	Hypertrophic obstructive cardiomyopathy	4.5%
481	Mitochondrial Encephalomyopathies	4.4%
482	Osteochondritis	4.4%
483	Polymyalgia Rheumatica	4.4%
484	Sick Sinus Syndrome	4.4%
485	Cecal Neoplasms	4.4%
486	Duodenal Neoplasms	4.4%
487	Dermatomycoses	4.4%
488	Intestinal Atresia	4.4%
489	Skin Diseases, Bacterial	4.4%
490	Intestinal Fistula	4.4%
491	Osteogenesis Imperfecta	4.4%
492	Enterocutaneous Fistula	4.4%
493	Drug Eruptions	4.4%
494	Hyperlipoproteinemia Type IV	4.3%
495	Hyperlipoproteinemia Type V	4.3%
496	Appendicitis	4.3%
497	Granulomatosis with polyangiitis	4.3%
498	Keloid	4.3%
499	Hepatolenticular Degeneration	4.3%
500	Hypolipoproteinemias	4.3%
501	Connective Tissue Diseases	4.3%
502	Nutrition Disorders	4.3%
503	Acidosis	4.2%
504	Alkalosis	4.2%
505	Amyloidosis	4.2%
506	Hyperglycemia	4.2%
507	Hyperinsulinism	4.2%
508	Hyperkalemia	4.2%
509	Hypernatremia	4.2%
510	Hypoglycemia	4.2%
511	Hypokalemia	4.2%
512	Hyponatremia	4.2%
513	Xanthomatosis	4.2%
514	Hypophosphatemia	4.2%
515	Metabolic acidosis	4.2%
516	Dyslipidemias	4.2%
517	Iron Overload	4.2%
518	Xanthoma	4.2%
519	Reye Syndrome	4.2%
520	Systemic Scleroderma	4.1%
521	Gaucher Disease	4.1%
522	Kearns-Sayre syndrome	4.1%
523	Glycogen storage disease type II	4.1%
524	Tinea Pedis	4.1%
525	Biliary Tract Diseases	4.1%
526	Liver diseases	4.1%
527	Pancreatic Diseases	4.1%
528	Supravalvular aortic stenosis	4%
529	Lown-Ganong-Levine Syndrome	4%
530	Mycetoma	4%
531	Rheumatoid Arthritis	4%
532	Nail-Patella Syndrome	4%
533	Juvenile arthritis	4%
534	Adrenoleukodystrophy	4%
535	Mucopolysaccharidosis II	3.9%
536	Lupus Nephritis	3.9%
537	Hepatic Encephalopathy	3.8%
538	Diabetic Ketoacidosis	3.8%
539	Hyperlipidemia, Familial Combined	3.8%
540	Diabetes Mellitus	3.8%
541	Amyloid Neuropathies, Familial	3.7%
542	Nesidioblastosis	3.7%
543	Rectal Fistula	3.7%
544	Anal Fistula	3.7%
545	Dehydration	3.7%
546	Water Intoxication	3.7%
547	Werner Syndrome	3.7%
548	Lichen Planus	3.7%
549	Melanosis	3.7%
550	Chloasma	3.7%
551	Pityriasis Rosea	3.7%
552	Pityriasis Rubra Pilaris	3.7%
553	Vitiligo	3.7%
554	Lichen Nitidus	3.7%
555	Amino Acid Metabolism, Inborn Errors	3.7%
556	Bloom Syndrome	3.7%
557	Carbohydrate Metabolism, Inborn Errors	3.7%
558	Metal Metabolism, Inborn Errors	3.7%
559	Osteoporosis	3.7%
560	Progeria	3.7%
561	Lysosomal Storage Diseases	3.7%
562	Bone Demineralization, Pathologic	3.7%
563	Cytochrome-c Oxidase Deficiency	3.7%
564	Peroxisomal Disorders	3.7%
565	Post-Traumatic Osteoporosis	3.7%
566	Laryngomalacia	3.6%
567	Crohn Disease	3.6%
568	Duodenal Obstruction	3.6%
569	Enterocolitis, Neutropenic	3.6%
570	Necrotizing Enterocolitis	3.6%
571	Pectus carinatum	3.6%
572	Gastrointestinal Stromal Tumors	3.6%
573	Adams-Stokes Syndrome	3.6%
574	Atrioventricular Block	3.6%
575	Bundle-Branch Block	3.6%
576	Atrial Premature Complexes	3.6%
577	Sinoatrial Block	3.6%
578	Tachycardia, Paroxysmal	3.6%
579	Supraventricular tachycardia	3.6%
580	Tachycardia, Ventricular	3.6%
581	Wolff-Parkinson-White Syndrome	3.6%
582	Tachycardia, Reciprocating	3.6%
583	Aortopulmonary Septal Defect	3.6%
584	Double Outlet Right Ventricle	3.6%
585	Endocardial Cushion Defects	3.6%
586	Myocardial bridging	3.6%
587	Aorticopulmonary Septal Defect	3.6%
588	Digestive System Neoplasms	3.6%
589	Carcinoid Heart Disease	3.6%
590	HIV Wasting Syndrome	3.6%
591	Subacute Bacterial Endocarditis	3.5%
592	Renal tubular acidosis	3.5%
593	Hyperlipoproteinemia Type III	3.5%
594	Cecal Diseases	3.5%
595	Colonic Diseases	3.5%
596	Ileal Diseases	3.5%
597	Intestinal Obstruction	3.5%
598	Intestinal Perforation	3.5%
599	Jejunal Diseases	3.5%
600	Pneumatosis Cystoides Intestinalis	3.5%
601	Rectal Diseases	3.5%
602	Gastric Dilatation	3.5%
603	Gastric outlet obstruction	3.5%
604	Cronkhite-Canada Syndrome	3.5%
605	Intestinal Polyposis	3.5%
606	Niemann-Pick Disease, Type C	3.4%
607	Refsum Disease	3.4%
608	Tay-Sachs Disease	3.4%
609	Liver neoplasms	3.3%
610	Pancreatic Fistula	3.3%
611	Mitochondrial Myopathies	3.3%
612	Myelinolysis, Central Pontine	3.3%
613	Alopecia	3.3%
614	Sweating, Gustatory	3.3%
615	Androgenetic Alopecia	3.3%
616	Auriculotemporal Syndrome	3.3%
617	Glycosuria	3.3%
618	Aortic Valve Insufficiency	3.2%
619	Restrictive cardiomyopathy	3.2%
620	Endocardial Fibroelastosis	3.2%
621	Heart Rupture, Post-Infarction	3.2%
622	Mitral Valve Insufficiency	3.2%
623	Mitral Valve Stenosis	3.2%
624	Myocarditis	3.2%
625	Pericarditis, Constrictive	3.2%
626	Pulmonary Valve Insufficiency	3.2%
627	Tricuspid Valve Insufficiency	3.2%
628	Tricuspid Valve Stenosis	3.2%
629	Ventricular Dysfunction, Left	3.2%
630	Right Ventricular Dysfunction	3.2%
631	Endomyocardial Fibrosis	3.2%
632	Carditis	3.2%
633	Heart Failure, Systolic	3.2%
634	Heart Failure, Diastolic	3.2%
635	Lice Infestations	3.2%
636	Breast Neoplasms, Male	3.2%
637	Triple Negative Breast Neoplasms	3.2%
638	Galactorrhea	3.2%
639	Enterocolitis, Pseudomembranous	3.2%
640	pseudomembranous colitis	3.2%
641	Dysentery, Bacillary	3.2%
642	Romano-Ward Syndrome	3.2%
643	Hematoma, Subdural	3.2%
644	Hematoma, Epidural, Cranial	3.2%
645	Pouchitis	3.2%
646	Hypoalphalipoproteinemias	3.2%
647	Intestinal Diseases, Parasitic	3.1%
648	Adenomatous Polyposis Coli	3.1%
649	Peutz-Jeghers Syndrome	3.1%
650	Neuronal Ceroid-Lipofuscinoses	3.1%
651	Peptic Ulcer Hemorrhage	3%
652	Gastroparesis	3%
653	Duodenal Ulcer	3%
654	Peptic Ulcer Perforation	3%
655	Gastric ulcer	3%
656	Wernicke Encephalopathy	3%
657	Peritoneal Neoplasms	3%
658	Glycosuria, Renal	3%
659	Brain Hemorrhage, Traumatic	3%
660	Fanconi Anemia	2.9%
661	Larva Migrans	2.9%
662	Leishmaniasis	2.9%
663	Molluscum Contagiosum	2.9%
664	Appendiceal Neoplasms	2.9%
665	Colonic Neoplasms	2.9%
666	Rectal Neoplasms	2.9%
667	Onchocerciasis	2.9%
668	Chromoblastomycosis	2.9%
669	Dermatophytosis	2.9%
670	Rheumatoid Nodule	2.9%
671	Sporotrichosis	2.9%
672	Tinea	2.9%
673	Tinea Versicolor	2.9%
674	Trichophytosis	2.9%
675	Hyalohyphomycosis	2.9%
676	Acute Generalized Exanthematous Pustulosis	2.9%
677	Tachycardia, Atrioventricular Nodal Reentry	2.9%
678	Tachycardia, Ectopic Atrial	2.9%
679	Tachycardia, Ectopic Junctional	2.9%
680	Sinus Tachycardia	2.9%
681	Torsades de Pointes	2.9%
682	Accelerated Idioventricular Rhythm	2.9%
683	Truncus Arteriosus, Persistent	2.9%
684	Sinus Arrhythmia	2.9%
685	Atrial Fibrillation	2.9%
686	Atrial Flutter	2.9%
687	Edema, Cardiac	2.9%
688	Ventricular Fibrillation	2.9%
689	Ventricular Flutter	2.9%
690	Parasystole	2.9%
691	Paroxysmal atrial fibrillation	2.9%
692	Bradycardia	2.9%
693	Diabetic Cardiomyopathies	2.9%
694	Cardiomyopathy, Alcoholic	2.8%
695	Ectopia Cordis	2.8%
696	Sudden Cardiac Death	2.8%
697	Left Ventricular Hypertrophy	2.8%
698	Right Ventricular Hypertrophy	2.8%
699	Single umbilical artery	2.8%
700	Chagas Cardiomyopathy	2.8%
701	Hematoma, Subdural, Intracranial	2.8%
702	Hematoma, Subdural, Chronic	2.8%
703	Hematoma, Subdural, Acute	2.8%
704	Anus Neoplasms	2.8%
705	Sigmoid Neoplasms	2.8%
706	Acidosis, Lactic	2.8%
707	Hemosiderosis	2.8%
708	Ketosis	2.8%
709	Ketonuria	2.8%
710	Ketoacidosis	2.8%
711	Ketonemia	2.8%
712	Acanthosis Nigricans	2.8%
713	Alopecia Areata	2.8%
714	Lentigo	2.8%
715	Melena	2.7%
716	Pancreatic Neoplasm	2.7%
717	Hematemesis	2.7%
718	Friedreich Ataxia	2.6%
719	Warts	2.6%
720	Candidiasis, Chronic Mucocutaneous	2.6%
721	Cutaneous Candidiasis	2.6%
722	Felty Syndrome	2.6%
723	Bronchomalacia	2.6%
724	Tracheomalacia	2.6%
725	Erysipelas	2.6%
726	Serum Sickness	2.6%
727	Staphylococcal Skin Infections	2.6%
728	Erythrasma	2.6%
729	Carcinoma, Lobular	2.6%
730	Arthritis, Psoriatic	2.6%
731	Dyspnea, Paroxysmal	2.5%
732	Kernicterus	2.5%
733	Cockayne Syndrome	2.5%
734	Lichen Planus, Oral	2.4%
735	Bile Duct Neoplasms	2.4%
736	gallbladder neoplasm	2.4%
737	Scleroderma, Limited	2.4%
738	Acidosis, Respiratory	2.4%
739	Alkalosis, Respiratory	2.4%
740	Alkaptonuria	2.4%
741	Glycogen Storage Disease	2.4%
742	Hypophosphatasia	2.4%
743	Insulin Resistance	2.4%
744	Osteoporosis, Postmenopausal	2.4%
745	Propionic acidemia	2.4%
746	Dihydropyrimidine Dehydrogenase Deficiency	2.4%
747	Cystinosis	2.4%
748	Turner Syndrome	2.4%
749	Child Nutrition Disorders	2.3%
750	Hypervitaminosis A	2.3%
751	Infant Nutrition Disorders	2.3%
752	Malnutrition	2.3%
753	Choledochal Cyst	2.3%
754	Aortic Valve Prolapse	2.3%
755	Tricuspid Valve Prolapse	2.3%
756	Takotsubo Cardiomyopathy	2.3%
757	Dural Arteriovenous Fistula	2.3%
758	Optic Atrophy, Hereditary, Leber	2.2%
759	Gestational Diabetes	2.2%
760	Latent Autoimmune Diabetes in Adults	2.2%
761	Diabetes Mellitus, Experimental	2.2%
762	Blastomycosis	2.2%
763	Sicca Syndrome	2.2%
764	Sjogren's Syndrome	2.2%
765	Biliary cirrhosis	2.2%
766	Leishmaniasis, Cutaneous	2.2%
767	Eczema Herpeticum	2.2%
768	Fusariosis	2.1%
769	Colonic Pseudo-Obstruction	2.1%
770	Bile Duct Diseases	2.1%
771	Cholelithiasis	2.1%
772	Chylous Ascites	2.1%
773	Fatty Liver	2.1%
774	Hepatitis	2.1%
775	Portal Hypertension	2.1%
776	Liver Cirrhosis	2.1%
777	Pancreatic Insufficiency	2.1%
778	Pancreatitis	2.1%
779	Pneumoperitoneum	2.1%
780	Focal Nodular Hyperplasia	2.1%
781	Hepatic Insufficiency	2.1%
782	Steatohepatitis	2.1%
783	Colonic Diseases, Functional	2.1%
784	Fecal Incontinence	2.1%
785	Fecal Impaction	2.1%
786	Intussusception	2.1%
787	Megacolon	2.1%
788	Pyloric Stenosis	2.1%
789	Ileus	2.1%
790	Meconium ileus	2.1%
791	Canavan Disease	2.1%
792	Alexander Disease	2.1%
793	Hypercholesterolemia	2.1%
794	Hyperlipoproteinemias	2.1%
795	Hypertriglyceridemia	2.1%
796	Cholecystolithiasis	2%
797	Rhinoscleroma	2%
798	Sinus Arrest, Cardiac	2%
799	Familial Periodic Paralysis	2%
800	Primary amyloidosis	2%
801	Epidermodysplasia Verruciformis	1.9%
802	Herpes Labialis	1.9%
803	Renal Aminoacidurias	1.9%
804	Fanconi Syndrome	1.9%
805	Pseudohypoaldosteronism	1.9%
806	Liddle Syndrome	1.9%
807	Staphylococcal Scalded Skin Syndrome	1.9%
808	Liver Diseases, Parasitic	1.9%
809	Pancreatic Cyst	1.9%
810	Hepatopulmonary Syndrome	1.9%
811	Anus, Imperforate	1.8%
812	Hemoperitoneum	1.8%
813	Hepatomegaly	1.8%
814	Peritonitis	1.8%
815	Peritoneal Fibrosis	1.8%
816	Encapsulating Peritoneal Sclerosis	1.8%
817	Anorectal Malformations	1.8%
818	Biliary Fistula	1.8%
819	Gastric Fistula	1.8%
820	Liver Abscess	1.8%
821	Kartagener Syndrome	1.8%
822	Afferent Loop Syndrome	1.8%
823	Short Bowel Syndrome	1.8%
824	Rectocele	1.8%
825	Diverticulitis	1.8%
826	Dumping Syndrome	1.8%
827	Rectal Prolapse	1.8%
828	Glycogen Storage Disease Type I	1.8%
829	Glycogen Storage Disease Type V	1.8%
830	Fatty Liver, Alcoholic	1.8%
831	Hepatitis, Alcoholic	1.8%
832	Liver Cirrhosis, Alcoholic	1.8%
833	Gout	1.8%
834	Amyotrophic Lateral Sclerosis	1.8%
835	Condylomata Acuminata	1.8%
836	Furunculosis	1.8%
837	furuncle	1.8%
838	Antley-Bixler Syndrome Phenotype	1.8%
839	Impetigo	1.8%
840	Chemical and Drug Induced Liver Injury	1.7%
841	Giardiasis	1.7%
842	Hepatorenal Syndrome	1.6%
843	Diverticulum	1.6%
844	Diverticulosis	1.6%
845	Hepatocellular Adenoma	1.6%
846	Choledocholithiasis	1.6%
847	carbuncle	1.6%
848	Cystic Fibrosis	1.5%
849	Liver Abscess, Amebic	1.5%
850	Liver Neoplasms, Experimental	1.5%
851	Hypokalemic periodic paralysis	1.5%
852	Frontotemporal dementia	1.4%
853	Cystinuria	1.4%
854	Deficiency Diseases	1.4%
855	Starvation	1.4%
856	Refeeding Syndrome	1.4%
857	Anal Fissure	1.4%
858	Intestinal Pseudo-Obstruction	1.4%
859	Irritable Bowel Syndrome	1.4%
860	Superior Mesenteric Artery Syndrome	1.4%
861	Neurogenic Bowel	1.4%
862	Anal Ulcer	1.4%
863	Arthritis, Gouty	1.3%
864	Williams Syndrome	1.3%
865	Carcinoma, Pancreatic Ductal	1.2%
866	Cryptosporidiosis	1.2%
867	Cholangitis	1.2%
868	Cholecystitis	1.2%
869	Cholestasis	1.2%
870	Common Bile Duct Diseases	1.2%
871	Hepatitis, Chronic	1.2%
872	Liver Failure	1.2%
873	Pancreatitis, Chronic	1.2%
874	Non-alcoholic Fatty Liver Disease	1.2%
875	Chronic active hepatitis	1.2%
876	Hepatitis, Animal	1%
877	Hepatitis, Viral, Human	1%
878	Liver Cirrhosis, Experimental	1%
879	Pancreatic Pseudocyst	1%
880	Pancreatitis, Alcoholic	1%
881	Obesity	1%
882	Kwashiorkor	0.9%
883	Magnesium Deficiency	0.9%
884	Potassium Deficiency	0.9%
885	Protein Deficiency	0.9%
886	Avitaminosis	0.9%
887	Fascioliasis	0.9%
888	Echinococcosis, Hepatic	0.9%
889	Chemical and Drug Induced Liver Injury, Chronic	0.9%
890	Hepatitis B, Chronic	0.8%
891	Hepatitis C, Chronic	0.8%
892	insulinoma	0.8%
893	Gastrinoma	0.8%
894	Glucagonoma	0.8%
895	Vipoma	0.7%
896	Obesity, Abdominal	0.7%
897	Cholestasis, Extrahepatic	0.7%
898	Biliary Dyskinesia	0.7%
899	Cholangitis, Sclerosing	0.7%
900	Liver Failure, Acute	0.7%
901	Acalculous Cholecystitis	0.7%
902	End Stage Liver Disease	0.7%
903	Ascorbic Acid Deficiency	0.7%
904	Vitamin A Deficiency	0.7%
905	Vitamin D Deficiency	0.7%
906	Vitamin E Deficiency	0.7%
907	Marasmus	0.7%
908	Pediatric Obesity	0.6%
909	Autoimmune hepatitis	0.6%
910	Prader-Willi Syndrome	0.6%
911	Folic Acid Deficiency	0.6%
912	Pellagra	0.6%
913	Thiamine Deficiency	0.6%
914	Vitamin B 12 Deficiency	0.6%
915	Vitamin B 6 Deficiency	0.6%
916	Pyridoxine Deficiency	0.6%
917	Hepatitis, Viral, Animal	0.6%
918	Hepatitis E	0.6%
919	Hepatitis B	0.5%
920	Hepatitis C	0.5%
921	Hepatitis A	0.5%
922	Vitamin K Deficiency	0.5%
923	Beriberi	0.5%
924	Massive Hepatic Necrosis	0.5%
925	Emphysematous Cholecystitis	0.5%
926	Sphincter of Oddi Dysfunction	0.5%
927	Anemia, Pernicious	0.5%
928	Subacute Combined Degeneration	0.3%
929	Rift Valley Fever	0.3%

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