MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Acute intermittent porphyria

(UMLS:C0162565)

Definition:: An autosomal dominant porphyria that is due to a deficiency of HYDROXYMETHYLBILANE SYNTHASE in the LIVER, the third enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features are recurrent and life-threatening neurologic disturbances, ABDOMINAL PAIN, and elevated level of AMINOLEVULINIC ACID and PORPHOBILINOGEN in the urine.
UMLS ID:: C0162565
MeSH ID:: D017118

Classification 1:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.552.830.150

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.850.742.150

Classification 3:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.827.742.150

Classification 4:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.811.400.150

Synonym(s)

Acute intermittent porphyria

AIP (acute intermittent porphyria)

AIP - Acute intermittent porphyria

Acute Intermittent Porphyria

Acute porphyria

Intermittent acute porphyria

Intermittent acute porphyria syndrome

PORPHYRIA ACUTE INTERMITTENT

PORPHYRIA, ACUTE INTERMITTENT

10.

Porphyria acute

11.

Porphyria, Acute Intermittent

12.

Porphyria, acute intermittent

13.

Pyrrole porphyria

14.

Pyrroloporphyria

15.

Swedish genetic porphyria

16.

Swedish porphyria

Associated Drug(s)

	Name	Data Source
1	Doxepin	OFFSIDES
2	Letrozole	OFFSIDES
3	Phenytoin	OFFSIDES
4	Pramipexole	OFFSIDES
5	cyclobenzaprine	OFFSIDES
6	ifenprodil	OFFSIDES
7	temocapril hydrochloride	OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Variegate Porphyria	48%
2	Porphyria Cutanea Tarda	48%
3	Porokeratosis	23.9%
4	Keratoderma, Palmoplantar	23.9%
5	Epidermolysis Bullosa	23.1%
6	Xeroderma Pigmentosum	22.4%
7	Cutis Laxa	22.3%
8	Dermatitis, Atopic	22%
9	Ectodermal Dysplasia	20.9%
10	Aplasia Cutis Congenita	20.9%
11	Albinism	20.7%
12	Ichthyosis, X-Linked	20.1%
13	Sjogren-Larsson Syndrome	18.5%
14	Pseudoxanthoma Elasticum	17.8%
15	Papillon-Lefevre Disease	15.7%
16	Lipomatosis	13.3%
17	Werner Syndrome	13.3%
18	Hyperkeratosis, Epidermolytic	13%
19	Lipodystrophy	12.7%
20	Pyoderma Gangrenosum	12.7%
21	Hepatolenticular Degeneration	12.4%
22	Biliary cirrhosis	12.4%
23	Fatty Liver	11.9%
24	Hepatitis	11.9%
25	Portal Hypertension	11.9%
26	Liver Cirrhosis	11.9%
27	Focal Nodular Hyperplasia	11.9%
28	Hepatic Insufficiency	11.9%
29	Steatohepatitis	11.9%
30	Zellweger Syndrome	11.9%
31	Necrobiosis Lipoidica Diabeticorum	11.9%
32	Menkes Kinky Hair Syndrome	11.8%
33	Liver neoplasms	11.5%
34	Nail-Patella Syndrome	11.3%
35	Fatty Liver, Alcoholic	11.2%
36	Hepatitis, Alcoholic	11.2%
37	Liver Cirrhosis, Alcoholic	11.2%
38	Lupus Erythematosus, Cutaneous	11.2%
39	Panniculitis	11.2%
40	Systemic Scleroderma	11.2%
41	Skin Abnormalities	11.2%
42	Wasting Syndrome	11.2%
43	Morphea	11.2%
44	Brain Diseases, Metabolic, Inborn	11.1%
45	Cystic Fibrosis	11.1%
46	Pseudohypoparathyroidism	10.9%
47	Xeroderma	10.8%
48	Smith-Lemli-Opitz Syndrome	10.7%
49	Leigh Disease	10.6%
50	Behcet Syndrome	10.5%
51	Liver Diseases, Parasitic	10.3%
52	Hepatic Veno-Occlusive Disease	10.1%
53	Peliosis Hepatis	10.1%
54	Hepatopulmonary Syndrome	10.1%
55	Hepatomegaly	9.9%
56	Acid-Base Imbalance	9.9%
57	Breast Diseases	9.9%
58	Calcium Metabolism Disorders	9.9%
59	Dermatitis	9.9%
60	Iron Metabolism Disorders	9.9%
61	Exanthema	9.9%
62	Facial Dermatoses	9.9%
63	Hair Diseases	9.9%
64	Hand Dermatoses	9.9%
65	keratoacanthoma	9.9%
66	Keratosis	9.9%
67	Nail Diseases	9.9%
68	Phosphorus Metabolism Disorders	9.9%
69	Photosensitivity Disorders	9.9%
70	Prurigo	9.9%
71	Pyoderma	9.9%
72	Rosacea	9.9%
73	Sebaceous Gland Diseases	9.9%
74	Skin Diseases, Vesiculobullous	9.9%
75	Skin Ulcer	9.9%
76	Sweat Gland Diseases	9.9%
77	Water-Electrolyte Imbalance	9.9%
78	Lipid Metabolism Disorders	9.9%
79	Skin Diseases, Papulosquamous	9.9%
80	Skin Diseases, Vascular	9.9%
81	Acneiform Eruptions	9.9%
82	Ocular Rosacea	9.9%
83	Subcorneal pustular dermatosis	9.9%
84	Mitochondrial Diseases	9.9%
85	Glucose Metabolism Disorders	9.9%
86	Erythematotelangiectatic Rosacea	9.9%
87	Papulopustular Rosacea	9.9%
88	Chronic Actinic Dermatitis	9.9%
89	Cockayne Syndrome	9.9%
90	Hepatic Vein Thrombosis	9.9%
91	Liver Abscess	9.9%
92	Budd-Chiari Syndrome	9.9%
93	Acrodermatitis	9.9%
94	Gianotti-Crosti Syndrome	9.9%
95	Acne Vulgaris	9.8%
96	Amino Acid Metabolism, Inborn Errors	9.8%
97	Carbohydrate Metabolism, Inborn Errors	9.8%
98	Contact Dermatitis	9.8%
99	Eczema	9.8%
100	Erythema Multiforme	9.8%
101	Hypercalcemia	9.8%
102	Hypocalcemia	9.8%
103	Intertrigo	9.8%
104	Metal Metabolism, Inborn Errors	9.8%
105	Milk-Alkali Syndrome	9.8%
106	Neurodermatitis	9.8%
107	Progeria	9.8%
108	Rhinophyma	9.8%
109	Lysosomal Storage Diseases	9.8%
110	Perioral Dermatitis	9.8%
111	Cytochrome-c Oxidase Deficiency	9.8%
112	Peroxisomal Disorders	9.8%
113	Acne	9.8%
114	Reye Syndrome	9.8%
115	Lactose Intolerance	9.8%
116	Galactosemias	9.7%
117	Urea Cycle Disorders, Inborn	9.7%
118	Tyrosinemias	9.7%
119	Congenital Hyperinsulinism	9.5%
120	Homocystinuria	9.5%
121	Carbamoyl-Phosphate Synthase I Deficiency Disease	9.2%
122	Hyperhomocysteinemia	9%
123	Adrenoleukodystrophy	8.9%
124	Amyloid Neuropathies, Familial	8.8%
125	Hyperphosphaturia	8.8%
126	Liver Abscess, Amebic	8.8%
127	Esophageal and Gastric Varices	8.7%
128	Chemical and Drug Induced Liver Injury	8.7%
129	Neuronal Ceroid-Lipofuscinoses	8.7%
130	Foot Diseases	8.6%
131	Neoplastic Syndromes, Hereditary	8.6%
132	Mucopolysaccharidosis II	8.6%
133	Dermatitis Herpetiformis	8.5%
134	CHARGE Syndrome	8.5%
135	Hepatorenal Syndrome	8.5%
136	Osteogenesis Imperfecta	8.5%
137	Sebaceous Gland Neoplasms	8.5%
138	Glycogen storage disease type II	8.4%
139	Osteopenia	8.4%
140	Skin Diseases, Infectious	8.4%
141	Skin Neoplasms	8.4%
142	Pigmentation Disorders	8.4%
143	Hepatic Encephalopathy	8.4%
144	Hypolipoproteinemias	8.3%
145	Dermatitis, Phototoxic	8.3%
146	Pityriasis Lichenoides et Varioliformis Acuta	8.3%
147	Pityriasis Lichenoides	8.3%
148	Aicardi's syndrome	8.3%
149	Phototoxicity	8.3%
150	Brain Diseases, Metabolic	8.3%
151	Multiple Epiphyseal Dysplasia	8.3%
152	Osteochondrodysplasias	8.3%
153	Pelger-Huet Anomaly	8.3%
154	Pruritus	8.3%
155	Erythema	8.3%
156	Necrolytic Migratory Erythema	8.3%
157	Cutaneous Fistula	8.3%
158	Myasthenic Syndromes, Congenital	8.3%
159	Nephrogenic Fibrosing Dermopathy	8.3%
160	Nephrogenic Systemic Fibrosis	8.3%
161	Dermatomyositis	8.3%
162	Refsum Disease	8.2%
163	Panniculitis, Lupus Erythematosus	8.2%
164	Adiposis Dolorosa	8.2%
165	Foot Ulcer	8.2%
166	Angioedemas, Hereditary	8%
167	Fabry Disease	7.9%
168	Rickets	7.9%
169	Hyperlipoproteinemia Type IV	7.8%
170	Hyperlipoproteinemia Type V	7.8%
171	Hepatitis, Chronic	7.8%
172	Liver Failure	7.8%
173	Non-alcoholic Fatty Liver Disease	7.8%
174	Chronic active hepatitis	7.8%
175	Hyperlipidemia, Familial Combined	7.6%
176	Marfan Syndrome	7.6%
177	Gaucher Disease	7.5%
178	Erythema Induratum	7.5%
179	Familial Hypophosphatemic Rickets	7.4%
180	Anemia, Sickle Cell	7.4%
181	Thalassemia	7.4%
182	Muscular Dystrophy, Duchenne	7.3%
183	Dwarfism	7.3%
184	Fanconi Anemia	7.3%
185	Dermatitis, Photoallergic	7.3%
186	Hyperlipoproteinemia Type III	7.3%
187	Ataxia Telangiectasia	7.3%
188	Fragile X Syndrome	7.2%
189	Mucopolysaccharidosis III	7.1%
190	Achlorhydria	7.1%
191	Mastocytosis	7.1%
192	Muscular Dystrophy	7.1%
193	Beckwith-Wiedemann Syndrome	7%
194	Wolf-Hirschhorn Syndrome	7%
195	Urticaria Pigmentosa	7%
196	Biliary Tract Diseases	6.8%
197	Gastrointestinal Diseases	6.8%
198	Pancreatic Diseases	6.8%
199	Hepatitis, Animal	6.8%
200	Hepatitis, Viral, Human	6.8%
201	Hepatitis B, Chronic	6.7%
202	Hepatitis C, Chronic	6.7%
203	Bloom Syndrome	6.6%
204	Liver Cirrhosis, Experimental	6.6%
205	Lupus Erythematosus, Discoid	6.6%
206	Scleroderma, Limited	6.6%
207	Hepatocellular Adenoma	6.5%
208	Celiac Disease	6.5%
209	Sprue, Tropical	6.5%
210	Steatorrhea	6.5%
211	Sprue	6.5%
212	Nesidioblastosis	6.5%
213	Alkaptonuria	6.5%
214	Glycogen Storage Disease	6.5%
215	Hypophosphatasia	6.5%
216	Dermatitis, Irritant	6.5%
217	Acne Conglobata	6.5%
218	Propionic acidemia	6.5%
219	Dihydropyrimidine Dehydrogenase Deficiency	6.5%
220	Cystinosis	6.5%
221	Renal tubular acidosis	6.5%
222	Peutz-Jeghers Syndrome	6.5%
223	Zollinger-Ellison syndrome	6.4%
224	Autoimmune Lymphoproliferative Syndrome	6.3%
225	Tay-Sachs Disease	6.3%
226	Alstrom Syndrome	6.3%
227	Pruritus Ani	6.2%
228	Smith-Magenis syndrome	6.2%
229	Hypoalphalipoproteinemias	6.2%
230	Optic Atrophy, Hereditary, Leber	6.2%
231	Niemann-Pick Disease, Type C	6.2%
232	Erythema Infectiosum	6.2%
233	Prader-Willi Syndrome	6.2%
234	Exanthema Subitum	6.2%
235	Esophageal Atresia	6.2%
236	Intestinal Atresia	6.2%
237	Cri-du-Chat Syndrome	6.1%
238	Down Syndrome	6.1%
239	Trisomy 21	6.1%
240	Connective Tissue Diseases	6.1%
241	Deformity	6.1%
242	Nutrition Disorders	6.1%
243	Erythema Nodosum	6.1%
244	Canavan Disease	6.1%
245	Alexander Disease	6.1%
246	Kartagener Syndrome	6%
247	Wiskott-Aldrich Syndrome	5.9%
248	Acidosis	5.9%
249	Alkalosis	5.9%
250	Amyloidosis	5.9%
251	Anhidrosis	5.9%
252	Calcinosis	5.9%
253	Cholesteatoma	5.9%
254	Pressure Ulcer	5.9%
255	Folliculitis	5.9%
256	Foot Dermatoses	5.9%
257	Gynecomastia	5.9%
258	Hyperglycemia	5.9%
259	Hyperinsulinism	5.9%
260	Hyperkalemia	5.9%
261	Hypernatremia	5.9%
262	Hypertrichosis	5.9%
263	Hypoglycemia	5.9%
264	Hypohidrosis	5.9%
265	Hypokalemia	5.9%
266	Hyponatremia	5.9%
267	Hypotrichosis	5.9%
268	Leg Ulcer	5.9%
269	Miliaria	5.9%
270	Parakeratosis	5.9%
271	Parapsoriasis	5.9%
272	Familial Mediterranean Fever	5.9%
273	Pityriasis	5.9%
274	Psoriasis	5.9%
275	Xanthomatosis	5.9%
276	Sweet Syndrome	5.9%
277	Hidradenitis	5.9%
278	Onycholysis	5.9%
279	Hypophosphatemia	5.9%
280	Miliaria Rubra	5.9%
281	Hyperpigmentation	5.9%
282	Lichenoid Eruptions	5.9%
283	Metabolic acidosis	5.9%
284	Dyslipidemias	5.9%
285	Chloracne	5.9%
286	Iron Overload	5.9%
287	Xanthoma	5.9%
288	Liver Neoplasms, Experimental	5.9%
289	Toxic Epidermal Necrolysis	5.8%
290	Stevens-Johnson Syndrome	5.8%
291	Liver Failure, Acute	5.8%
292	End Stage Liver Disease	5.8%
293	HIV-Associated Lipodystrophy Syndrome	5.8%
294	Gastrointestinal Neoplasms	5.7%
295	Dermatitis, Occupational	5.7%
296	Digestive System Neoplasms	5.7%
297	Pancreatic Fistula	5.7%
298	Fascioliasis	5.7%
299	Holoprosencephaly	5.7%
300	Echinococcosis, Hepatic	5.7%
301	Chemical and Drug Induced Liver Injury, Chronic	5.6%
302	Dermatitis, Allergic Contact	5.6%
303	MELAS Syndrome	5.6%
304	Rett Syndrome	5.5%
305	Adenomatous Polyposis Coli	5.5%
306	Tinea Capitis	5.5%
307	Onychomycosis	5.5%
308	Choledochal Cyst	5.4%
309	Ecthyma	5.4%
310	Mitochondrial Encephalomyopathies	5.4%
311	Friedreich Ataxia	5.4%
312	Kallmann Syndrome	5.4%
313	Myotonic Dystrophy	5.3%
314	CREST Syndrome	5.3%
315	Osteomalacia	5.3%
316	Glycosuria, Renal	5.3%
317	Fetal Diseases	5.1%
318	Granuloma Annulare	5.1%
319	Diabetes Mellitus	5.1%
320	Rubinstein-Taybi Syndrome	5.1%
321	Antley-Bixler Syndrome Phenotype	5%
322	Tuberous Sclerosis	5%
323	Peritoneal Neoplasms	5%
324	Acantholysis	5%
325	Anus, Imperforate	5%
326	Breast Cyst	5%
327	Dehydration	5%
328	Actinic keratosis	5%
329	Mesenteric Panniculitis	5%
330	Panniculitis, Peritoneal	5%
331	Pemphigoid, Benign Mucous Membrane	5%
332	Pemphigus	5%
333	Piedra	5%
334	Sunburn	5%
335	Water Intoxication	5%
336	Anorectal Malformations	5%
337	Autoimmune hepatitis	4.9%
338	Familial Periodic Paralysis	4.9%
339	Argyria	4.9%
340	Bile Duct Neoplasms	4.9%
341	gallbladder neoplasm	4.9%
342	Hirsutism	4.9%
343	Intestinal Neoplasms	4.9%
344	Lactation Disorder	4.9%
345	Mastitis	4.9%
346	Osteoporosis	4.9%
347	Stomach Neoplasms	4.9%
348	Urticaria	4.9%
349	Bone Demineralization, Pathologic	4.9%
350	Post-Traumatic Osteoporosis	4.9%
351	Pruritus Vulvae	4.9%
352	Polycystic Kidney Diseases	4.9%
353	Williams Syndrome	4.9%
354	Mastocytoma	4.9%
355	Diabetic Ketoacidosis	4.9%
356	Massive Hepatic Necrosis	4.9%
357	Renal Aminoacidurias	4.8%
358	Fanconi Syndrome	4.8%
359	Pseudohypoaldosteronism	4.8%
360	Liddle Syndrome	4.8%
361	Colorectal Neoplasms	4.8%
362	Sickle Cell Trait	4.8%
363	Diaper Rash	4.8%
364	Glycogen Storage Disease Type I	4.8%
365	Glycogen Storage Disease Type V	4.8%
366	Proctocolitis	4.8%
367	Mesenteric vascular insufficiency	4.8%
368	Primary Ciliary Dyskinesia	4.7%
369	Mesenteric Vascular Occlusion	4.7%
370	Intestinal Fistula	4.7%
371	Enterocutaneous Fistula	4.7%
372	Pancreatic Neoplasm	4.5%
373	Retinal Dysplasia	4.5%
374	Aniridia	4.5%
375	Erythema Chronicum Migrans	4.4%
376	Gout	4.4%
377	Esophageal Neoplasms	4.4%
378	Dysentery	4.4%
379	Enteritis	4.4%
380	Enterocolitis	4.4%
381	Esophagitis	4.4%
382	Gastritis	4.4%
383	Inflammatory Bowel Diseases	4.4%
384	Cholecystolithiasis	4.4%
385	Hepatitis, Viral, Animal	4.4%
386	HIV Wasting Syndrome	4.4%
387	Hidradenitis Suppurativa	4.3%
388	Cecal Neoplasms	4.3%
389	Duodenal Neoplasms	4.3%
390	Hepatitis E	4.3%
391	Dermatomycoses	4.3%
392	Mucocutaneous Lymph Node Syndrome	4.3%
393	Skin Diseases, Bacterial	4.3%
394	Mitochondrial Myopathies	4.3%
395	Hepatitis B	4.2%
396	Hepatitis C	4.2%
397	Retinitis Pigmentosa	4.2%
398	Myelinolysis, Central Pontine	4.2%
399	Pigmentary retinopathy	4.2%
400	Drug Eruptions	4.2%
401	Hepatitis A	4.2%
402	Livedo Reticularis	4.2%
403	Malignant Atrophic Papulosis	4.2%
404	Glycosuria	4.2%
405	Chronic granulomatous disease	4.2%
406	Polyarteritis Nodosa	4.2%
407	Takayasu Arteritis	4.2%
408	Welander Distal Myopathy	4.2%
409	Duodenitis	4.2%
410	Ileitis	4.2%
411	Erosive Duodenitis	4.2%
412	Rectal Fistula	4.1%
413	Anal Fistula	4.1%
414	Bile Duct Diseases	4%
415	Cholelithiasis	4%
416	Chylous Ascites	4%
417	Esophageal Diseases	4%
418	Gastroenteritis	4%
419	Intestinal Diseases	4%
420	Kernicterus	4%
421	Pancreatic Insufficiency	4%
422	Pancreatitis	4%
423	Pneumoperitoneum	4%
424	Stomach Diseases	4%
425	Acute Chest Syndrome	4%
426	Acidosis, Lactic	3.9%
427	Calciphylaxis	3.9%
428	Hemosiderosis	3.9%
429	Ketosis	3.9%
430	Lichen Planus	3.9%
431	Melanosis	3.9%
432	Chloasma	3.9%
433	Pityriasis Rosea	3.9%
434	Pityriasis Rubra Pilaris	3.9%
435	Vitiligo	3.9%
436	Ketonuria	3.9%
437	Lichen Nitidus	3.9%
438	Ketoacidosis	3.9%
439	Ketonemia	3.9%
440	Vascular calcification	3.9%
441	Renal Osteodystrophy	3.9%
442	Renal rickets	3.9%
443	Colitis	3.8%
444	Duodenogastric Reflux	3.8%
445	Peptic Ulcer	3.8%
446	Proctitis	3.8%
447	Choledocholithiasis	3.8%
448	Duane Retraction Syndrome	3.8%
449	Tinea Pedis	3.8%
450	Meconium Aspiration Syndrome	3.7%
451	Gastrointestinal Stromal Tumors	3.7%
452	Myotonia Congenita	3.7%
453	Thrombasthenia	3.7%
454	Antithrombin III Deficiency	3.7%
455	Protein C Deficiency	3.7%
456	Afibrinogenemia	3.7%
457	Dystonia Musculorum Deformans	3.7%
458	Factor VII Deficiency	3.7%
459	Factor X Deficiency	3.7%
460	Factor XII Deficiency	3.7%
461	Hemophilia A	3.7%
462	Activated Protein C Resistance	3.7%
463	Factor II deficiency	3.7%
464	Factor VIII Deficiency	3.7%
465	Factor V deficiency	3.7%
466	Factor XI Deficiency	3.7%
467	Hypoprothrombinemias	3.7%
468	Wernicke Encephalopathy	3.7%
469	Anus Neoplasms	3.7%
470	Sigmoid Neoplasms	3.7%
471	Lafora Disease	3.6%
472	Unverricht-Lundborg Syndrome	3.6%
473	Hypokalemic periodic paralysis	3.6%
474	Anemia, Diamond-Blackfan	3.6%
475	Cystinuria	3.6%
476	Appendiceal Neoplasms	3.6%
477	Colonic Neoplasms	3.6%
478	Rectal Neoplasms	3.6%
479	Mycetoma	3.5%
480	Pouchitis	3.4%
481	Multiple Endocrine Neoplasia	3.4%
482	Pancreatic Cyst	3.4%
483	Mobius Syndrome	3.3%
484	Gastrointestinal Hemorrhage	3.3%
485	Hemoperitoneum	3.3%
486	Peritonitis	3.3%
487	Peritoneal Fibrosis	3.3%
488	Encapsulating Peritoneal Sclerosis	3.3%
489	Abdominal Cramps	3.3%
490	Abnormalities, Drug-Induced	3.3%
491	Amniotic Band Syndrome	3.3%
492	Asphyxia Neonatorum	3.3%
493	Child Nutrition Disorders	3.3%
494	Collagen Diseases	3.3%
495	Hypervitaminosis A	3.3%
496	Infant Nutrition Disorders	3.3%
497	Infant, Premature, Diseases	3.3%
498	Mixed Connective Tissue Disease	3.3%
499	Situs Inversus	3.3%
500	Malnutrition	3.3%
501	Mucinoses	3.3%
502	Infantile Colic	3.3%
503	Congenital Hypothyroidism	3.3%
504	Alopecia	3.3%
505	Biliary Fistula	3.3%
506	Gastric Fistula	3.3%
507	Sweating, Gustatory	3.3%
508	Androgenetic Alopecia	3.3%
509	Auriculotemporal Syndrome	3.3%
510	Tuberculosis, Gastrointestinal	3.3%
511	Appendicitis	3.3%
512	Acidosis, Respiratory	3.3%
513	Alkalosis, Respiratory	3.3%
514	Lice Infestations	3.3%
515	Varicose Ulcer	3.3%
516	Breast Neoplasms, Male	3.3%
517	Triple Negative Breast Neoplasms	3.3%
518	Crohn Disease	3.2%
519	Duodenal Obstruction	3.2%
520	Insulin Resistance	3.2%
521	Osteoporosis, Postmenopausal	3.2%
522	Enterocolitis, Neutropenic	3.2%
523	Necrotizing Enterocolitis	3.2%
524	Galactorrhea	3.2%
525	Arthritis, Gouty	3.2%
526	Polycystic Kidney, Autosomal Dominant	3.2%
527	Classical Lissencephalies and Subcortical Band Heterotopias	3.1%
528	Kearns-Sayre syndrome	3.1%
529	Basal Cell Nevus Syndrome	3%
530	Noonan Syndrome	3%
531	Duodenal Ulcer	3%
532	Peptic Ulcer Perforation	3%
533	Gastric ulcer	3%
534	Acanthosis Nigricans	2.9%
535	Alopecia Areata	2.9%
536	Hypercholesterolemia	2.9%
537	Hyperlipoproteinemias	2.9%
538	Hypertriglyceridemia	2.9%
539	Lentigo	2.9%
540	Charcot-Marie-Tooth Disease	2.9%
541	Cartilage Diseases	2.9%
542	Eye Abnormalities	2.9%
543	Rheumatism	2.9%
544	Gestational Diabetes	2.9%
545	Chondromalacia	2.9%
546	Cardiovascular Abnormalities	2.9%
547	Latent Autoimmune Diabetes in Adults	2.9%
548	Diabetes Mellitus, Experimental	2.8%
549	Larva Migrans	2.8%
550	Leishmaniasis	2.8%
551	Molluscum Contagiosum	2.8%
552	Angioedema	2.8%
553	Onchocerciasis	2.8%
554	Lupus Erythematosus, Systemic	2.8%
555	Lymphatic Abnormalities	2.8%
556	Overlap syndrome	2.8%
557	Congenital Microtia	2.8%
558	Chromoblastomycosis	2.8%
559	Dermatophytosis	2.8%
560	Nephrocalcinosis	2.8%
561	Sporotrichosis	2.8%
562	Tetany	2.8%
563	Tinea	2.8%
564	Tinea Versicolor	2.8%
565	Trichophytosis	2.8%
566	Hyalohyphomycosis	2.8%
567	Enterocolitis, Pseudomembranous	2.8%
568	Acute Generalized Exanthematous Pustulosis	2.8%
569	pseudomembranous colitis	2.8%
570	Dysentery, Bacillary	2.8%
571	Anemia, Neonatal	2.8%
572	Persistent Fetal Circulation Syndrome	2.8%
573	Cerebral Amyloid Angiopathy	2.8%
574	Congenital diaphragmatic hernia	2.7%
575	Umbilical hernia	2.7%
576	Huntington Disease	2.7%
577	Giant Cell Arteritis	2.7%
578	Temporal Arteritis	2.7%
579	Cecal Diseases	2.6%
580	Cholangitis	2.6%
581	Cholecystitis	2.6%
582	Cholestasis	2.6%
583	Colonic Diseases	2.6%
584	Common Bile Duct Diseases	2.6%
585	Esophageal Stenosis	2.6%
586	Ileal Diseases	2.6%
587	Intestinal Obstruction	2.6%
588	Intestinal Perforation	2.6%
589	Jejunal Diseases	2.6%
590	Pneumatosis Cystoides Intestinalis	2.6%
591	Rectal Diseases	2.6%
592	Gastric Dilatation	2.6%
593	Pancreatitis, Chronic	2.6%
594	Gastric outlet obstruction	2.6%
595	Cronkhite-Canada Syndrome	2.6%
596	Intestinal Polyposis	2.6%
597	Colitis, Ischemic	2.6%
598	Colonic Pseudo-Obstruction	2.6%
599	Warts	2.5%
600	Rift Valley Fever	2.5%
601	Lichen Planus, Oral	2.5%
602	Urogenital Abnormalities	2.5%
603	Primary amyloidosis	2.5%
604	Candidiasis, Chronic Mucocutaneous	2.4%
605	Cutaneous Candidiasis	2.4%
606	Nephroblastoma	2.4%
607	Erysipelas	2.4%
608	Serum Sickness	2.4%
609	Staphylococcal Skin Infections	2.4%
610	Erythrasma	2.4%
611	Carcinoma, Lobular	2.4%
612	Arthritis, Psoriatic	2.4%
613	Neonatal Abstinence Syndrome	2.4%
614	Fetal Growth Retardation	2.4%
615	Carcinoma, Pancreatic Ductal	2.4%
616	Fetal Hypoxia	2.4%
617	Congenital nystagmus	2.4%
618	Fetal Alcohol Spectrum Disorders	2.4%
619	Dupuytren Contracture	2.4%
620	Toxoplasmosis, Congenital	2.3%
621	Anencephaly	2.3%
622	Syphilis, Congenital	2.3%
623	Esophageal Perforation	2.3%
624	Intestinal Diseases, Parasitic	2.3%
625	Laryngomalacia	2.2%
626	Hydrops Fetalis	2.2%
627	Pectus carinatum	2.2%
628	Barrett Esophagus	2.2%
629	Deglutition Disorders	2.2%
630	Klinefelter Syndrome	2.2%
631	Amyotrophic Lateral Sclerosis	2.2%
632	Pancreatic Pseudocyst	2.2%
633	Gastric Antral Vascular Ectasia	2.2%
634	Multiple Endocrine Neoplasia Type 1	2.2%
635	Peptic Ulcer Hemorrhage	2.2%
636	Gastroparesis	2.2%
637	Pancreatitis, Alcoholic	2.2%
638	Leishmaniasis, Cutaneous	2.1%
639	Eczema Herpeticum	2.1%
640	Turner Syndrome	2.1%
641	Fusariosis	2.1%
642	Cellulitis	2.1%
643	Chorioamnionitis	2.1%
644	Maxillofacial Abnormalities	2.1%
645	Dural Arteriovenous Fistula	2.1%
646	Dextrocardia	2%
647	Blastomycosis	2%
648	Deficiency Diseases	2%
649	Prune Belly Syndrome	2%
650	Starvation	2%
651	Twins, Conjoined	2%
652	Scleromyxedema	2%
653	Refeeding Syndrome	2%
654	Waardenburg Syndrome	2%
655	Cholestasis, Extrahepatic	1.9%
656	Biliary Dyskinesia	1.9%
657	Cholangitis, Sclerosing	1.9%
658	Colonic Diseases, Functional	1.9%
659	Esophageal motility disorders	1.9%
660	Fecal Incontinence	1.9%
661	Fecal Impaction	1.9%
662	Intussusception	1.9%
663	Mallory-Weiss Syndrome	1.9%
664	Megacolon	1.9%
665	Pyloric Stenosis	1.9%
666	Acalculous Cholecystitis	1.9%
667	Ileus	1.9%
668	Meconium ileus	1.9%
669	insulinoma	1.9%
670	Gastrinoma	1.9%
671	Glucagonoma	1.9%
672	Melena	1.9%
673	Hematemesis	1.9%
674	Epidermodysplasia Verruciformis	1.8%
675	Herpes Labialis	1.8%
676	Abnormalities, Radiation-Induced	1.8%
677	Diabetic Foot	1.8%
678	Rhinoscleroma	1.8%
679	Frontotemporal dementia	1.8%
680	Staphylococcal Scalded Skin Syndrome	1.8%
681	Vipoma	1.8%
682	Hereditary Angioedema Type III	1.7%
683	Hereditary Angioedema Types I and II	1.7%
684	Scimitar Syndrome	1.7%
685	Anophthalmos	1.7%
686	Hydranencephaly	1.7%
687	Microphthalmos	1.7%
688	Neural Tube Defects	1.7%
689	Paralysis, Obstetric	1.7%
690	Retinopathy of Prematurity	1.7%
691	Tietze's Syndrome	1.7%
692	Tethered Cord Syndrome	1.7%
693	Orbital Cellulitis	1.7%
694	Iniencephaly	1.7%
695	Craniorachischisis	1.7%
696	Limb Deformities, Congenital	1.7%
697	Exencephaly	1.7%
698	Septo-Optic Dysplasia	1.7%
699	Craniofacial Abnormalities	1.7%
700	Cortical Dysplasia	1.7%
701	Myxoid cyst	1.7%
702	Malformations of Cortical Development	1.7%
703	Hemorrhoids	1.6%
704	Myxedema	1.6%
705	Condylomata Acuminata	1.6%
706	Bronchomalacia	1.6%
707	Tracheomalacia	1.6%
708	Afferent Loop Syndrome	1.6%
709	Bronchopulmonary Dysplasia	1.6%
710	Short Bowel Syndrome	1.6%
711	Rectocele	1.6%
712	Ophthalmia Neonatorum	1.6%
713	Furunculosis	1.6%
714	furuncle	1.6%
715	Diverticulitis	1.6%
716	Dumping Syndrome	1.6%
717	Rectal Prolapse	1.6%
718	Esophageal Achalasia	1.6%
719	Anal Fissure	1.6%
720	Intestinal Pseudo-Obstruction	1.6%
721	Irritable Bowel Syndrome	1.6%
722	Superior Mesenteric Artery Syndrome	1.6%
723	Emphysematous Cholecystitis	1.6%
724	Neurogenic Bowel	1.6%
725	Sphincter of Oddi Dysfunction	1.6%
726	Anal Ulcer	1.6%
727	Impetigo	1.6%
728	Denys-Drash Syndrome	1.5%
729	carbuncle	1.5%
730	Craniosynostosis	1.4%
731	Syndactyly	1.4%
732	Brachycephaly	1.4%
733	Blepharophimosis	1.4%
734	Laryngostenosis	1.4%
735	Mouth Abnormalities	1.4%
736	Osteochondritis	1.4%
737	Polymyalgia Rheumatica	1.4%
738	Respiratory Distress Syndrome, Newborn	1.4%
739	Giardiasis	1.4%
740	Horseshoe Kidney	1.4%
741	Pectus excavatum	1.4%
742	Microcephaly	1.4%
743	Macrocephaly	1.4%
744	Klippel-Feil Syndrome	1.4%
745	Gastroschisis	1.4%
746	Synostosis	1.4%
747	Diverticulum	1.4%
748	Lymphangiectasis, Intestinal	1.4%
749	Diverticulosis	1.4%
750	Keloid	1.4%
751	Acrocephalosyndactylia	1.4%
752	Kwashiorkor	1.3%
753	Magnesium Deficiency	1.3%
754	Potassium Deficiency	1.3%
755	Protein Deficiency	1.3%
756	Avitaminosis	1.3%
757	Arthrogryposis	1.3%
758	Choanal Atresia	1.3%
759	Tracheobronchomegaly	1.3%
760	Laryngocele	1.3%
761	Rheumatoid Arthritis	1.3%
762	Hermaphroditism	1.3%
763	Disorders of Sex Development	1.3%
764	Juvenile arthritis	1.3%
765	Cryptorchidism	1.2%
766	Hypospadias	1.2%
767	Central Nervous System Cysts	1.2%
768	Dandy-Walker Syndrome	1.2%
769	Laryngopharyngeal Reflux	1.2%
770	Leukomalacia, Periventricular	1.2%
771	POEMS Syndrome	1.2%
772	Lupus Nephritis	1.2%
773	Obesity	1.2%
774	Porencephaly	1.2%
775	Cleft Palate	1.2%
776	Jaw Abnormalities	1.2%
777	Bladder Exstrophy	1.1%
778	Epispadias	1.1%
779	Multicystic Dysplastic Kidney	1.1%
780	Amelia	1.1%
781	Arachnodactyly	1.1%
782	Ectopia Cordis	1.1%
783	Ectromelia	1.1%
784	Hemimelia	1.1%
785	Meningomyelocele	1.1%
786	Phocomelia	1.1%
787	Sirenomelia	1.1%
788	Spina Bifida	1.1%
789	Polydactyly	1.1%
790	Brachydactyly	1.1%
791	Plagiocephaly	1.1%
792	Lower Extremity Deformities, Congenital	1.1%
793	Upper Extremity Deformities, Congenital	1.1%
794	Single umbilical artery	1.1%
795	Poland Syndrome	1.1%
796	Cryptosporidiosis	1%
797	Ascorbic Acid Deficiency	1%
798	Vitamin A Deficiency	1%
799	Vitamin D Deficiency	1%
800	Vitamin E Deficiency	1%
801	Marasmus	1%
802	Aortic coarctation	0.9%
803	Cor Triatriatum	0.9%
804	Coronary Vessel Anomalies	0.9%
805	Dental Enamel Hypoplasia	0.9%
806	Patent ductus arteriosus	0.9%
807	Ebstein Anomaly	0.9%
808	Heart Septal Defects	0.9%
809	Hyaline Membrane Disease	0.9%
810	Hypodontia	0.9%
811	Macrostomia	0.9%
812	Meningocele	0.9%
813	Microstomia	0.9%
814	Tetralogy of Fallot	0.9%
815	Transposition of Great Vessels	0.9%
816	Hypoplastic Left Heart Syndrome	0.9%
817	May-Thurner Syndrome	0.9%
818	Encephalocele	0.9%
819	Craniofacial Dysostosis	0.9%
820	Rheumatoid Nodule	0.9%
821	Wolff-Parkinson-White Syndrome	0.9%
822	Obesity, Abdominal	0.9%
823	Micrognathism	0.9%
824	Pierre Robin Syndrome	0.9%
825	Long QT Syndrome	0.8%
826	Platybasia	0.8%
827	Tricuspid Atresia	0.8%
828	Arrhythmogenic Right Ventricular Dysplasia	0.8%
829	Felty Syndrome	0.8%
830	Gonadal Dysgenesis	0.8%
831	Adrenogenital Syndrome	0.8%
832	Ovotesticular Disorders of Sex Development	0.8%
833	Retrognathia	0.8%
834	Dermal Sinus	0.8%
835	Spina Bifida Cystica	0.8%
836	Spina Bifida Occulta	0.8%
837	Lissencephaly	0.8%
838	Polymicrogyria	0.8%
839	Pachygyria	0.8%
840	Schizencephaly	0.8%
841	Periventricular Nodular Heterotopia	0.8%
842	Folic Acid Deficiency	0.8%
843	Pellagra	0.8%
844	Thiamine Deficiency	0.8%
845	Vitamin B 12 Deficiency	0.8%
846	Vitamin B 6 Deficiency	0.8%
847	Pyridoxine Deficiency	0.8%
848	Hyperandrogenism	0.8%
849	Pediatric Obesity	0.8%
850	Prognathism	0.7%
851	Beriberi	0.7%
852	Rheumatoid Vasculitis	0.7%
853	Vitamin K Deficiency	0.7%
854	Aortopulmonary Septal Defect	0.7%
855	Double Outlet Right Ventricle	0.7%
856	Endocardial Cushion Defects	0.7%
857	Myocardial bridging	0.7%
858	Aorticopulmonary Septal Defect	0.7%
859	Sicca Syndrome	0.7%
860	Sjogren's Syndrome	0.7%
861	Lupus Vasculitis, Central Nervous System	0.6%
862	Mandibulofacial Dysostosis	0.6%
863	Romano-Ward Syndrome	0.6%
864	Anemia, Pernicious	0.6%
865	Scurvy	0.6%
866	Truncus Arteriosus, Persistent	0.6%
867	Goldenhar Syndrome	0.6%
868	Talipes	0.5%
869	Arteriovenous fistula	0.5%
870	Congenital clubfoot	0.5%
871	Vertical Talus	0.5%
872	Subacute Combined Degeneration	0.4%

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