MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Papillon-Lefevre Disease

(UMLS:C0030360)

Definition:: Rare, autosomal recessive disorder occurring between the first and fifth years of life. It is characterized by palmoplantar keratoderma with periodontitis followed by the premature shedding of both deciduous and permanent teeth. Mutations in the gene for CATHEPSIN C have been associated with this disease.
UMLS ID:: C0030360
MeSH ID:: D010214

Classification 1:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.850.475.600

Classification 2:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.428.435.600|C17.800.827.475.600

Synonym(s)

Papillon-Lefevre Disease

Juvenile periodontosis with hyperkeratosis

PAPILLON-LEFEVRE SYNDROME

Papillon Lefevre syndrome

Papillon-Lefevre Syndrome

Papillon-Lefevre syndrome

Papillon-Lef猫vre syndrome

Periodontosis-Papillon-Lefebvre syndrome

papillon lefevre syndrome

10.

papillon-lefevre syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Acitretin		16008657	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Porokeratosis	44.3%
2	Epidermolysis Bullosa	37%
3	Dermatitis, Atopic	35.8%
4	Cutis Laxa	33.7%
5	Xeroderma Pigmentosum	32.6%
6	Ectodermal Dysplasia	30.9%
7	Aplasia Cutis Congenita	30.9%
8	Pyoderma Gangrenosum	29.5%
9	Ichthyosis, X-Linked	28%
10	Pseudoxanthoma Elasticum	27.2%
11	Lupus Erythematosus, Cutaneous	26.8%
12	Panniculitis	26.8%
13	Systemic Scleroderma	26.8%
14	Morphea	26.8%
15	Xeroderma	26.5%
16	Albinism	25.7%
17	Sjogren-Larsson Syndrome	25%
18	Breast Diseases	24.8%
19	Dermatitis	24.8%
20	Exanthema	24.8%
21	Facial Dermatoses	24.8%
22	Hair Diseases	24.8%
23	Hand Dermatoses	24.8%
24	keratoacanthoma	24.8%
25	Nail Diseases	24.8%
26	Photosensitivity Disorders	24.8%
27	Prurigo	24.8%
28	Pyoderma	24.8%
29	Rosacea	24.8%
30	Sebaceous Gland Diseases	24.8%
31	Skin Diseases, Vesiculobullous	24.8%
32	Skin Ulcer	24.8%
33	Sweat Gland Diseases	24.8%
34	Skin Diseases, Papulosquamous	24.8%
35	Skin Diseases, Vascular	24.8%
36	Acneiform Eruptions	24.8%
37	Ocular Rosacea	24.8%
38	Subcorneal pustular dermatosis	24.8%
39	Erythematotelangiectatic Rosacea	24.8%
40	Papulopustular Rosacea	24.8%
41	Chronic Actinic Dermatitis	24.8%
42	Cholesteatoma	24.4%
43	Parakeratosis	24.4%
44	Porphyrias, Hepatic	24.2%
45	Acne Vulgaris	23.5%
46	Contact Dermatitis	23.5%
47	Eczema	23.5%
48	Erythema Multiforme	23.5%
49	Intertrigo	23.5%
50	Neurodermatitis	23.5%
51	Rhinophyma	23.5%
52	Perioral Dermatitis	23.5%
53	Acne	23.5%
54	Skin Abnormalities	23.5%
55	Hyperkeratosis, Epidermolytic	21.9%
56	Acrodermatitis	21.3%
57	Gianotti-Crosti Syndrome	21.3%
58	Foot Diseases	20.7%
59	Skin Diseases, Infectious	20.1%
60	Skin Neoplasms	20.1%
61	Pigmentation Disorders	20.1%
62	Dermatitis Herpetiformis	19.9%
63	Actinic keratosis	19.9%
64	Lipomatosis	19.9%
65	Pruritus	19.9%
66	Erythema	19.9%
67	Necrolytic Migratory Erythema	19.9%
68	Cutaneous Fistula	19.9%
69	Nephrogenic Fibrosing Dermopathy	19.9%
70	Nephrogenic Systemic Fibrosis	19.9%
71	Sebaceous Gland Neoplasms	19.7%
72	Foot Ulcer	19.5%
73	Dermatitis, Phototoxic	19.4%
74	Pityriasis Lichenoides et Varioliformis Acuta	19.4%
75	Pityriasis Lichenoides	19.4%
76	Phototoxicity	19.4%
77	Dermatomyositis	18.9%
78	Necrobiosis Lipoidica Diabeticorum	18.7%
79	Panniculitis, Lupus Erythematosus	18.6%
80	Nail-Patella Syndrome	17.2%
81	Behcet Syndrome	17.2%
82	Dermatitis, Photoallergic	16.6%
83	Erythema Induratum	16.5%
84	Mastocytosis	16.5%
85	Urticaria Pigmentosa	16.2%
86	Variegate Porphyria	15.7%
87	Acute intermittent porphyria	15.7%
88	Porphyria Cutanea Tarda	15.7%
89	Lupus Erythematosus, Discoid	15.7%
90	Scleroderma, Limited	15.7%
91	Dermatitis, Irritant	15.5%
92	Acne Conglobata	15.5%
93	Connective Tissue Diseases	15.4%
94	Anhidrosis	14.6%
95	Pressure Ulcer	14.6%
96	Folliculitis	14.6%
97	Foot Dermatoses	14.6%
98	Gynecomastia	14.6%
99	Hypertrichosis	14.6%
100	Hypohidrosis	14.6%
101	Hypotrichosis	14.6%
102	Leg Ulcer	14.6%
103	Miliaria	14.6%
104	Parapsoriasis	14.6%
105	Pityriasis	14.6%
106	Psoriasis	14.6%
107	Sweet Syndrome	14.6%
108	Hidradenitis	14.6%
109	Onycholysis	14.6%
110	Miliaria Rubra	14.6%
111	Hyperpigmentation	14.6%
112	Lichenoid Eruptions	14.6%
113	Chloracne	14.6%
114	Erythema Infectiosum	14.2%
115	Exanthema Subitum	14.1%
116	Erythema Nodosum	13.9%
117	Dermatitis, Occupational	13.4%
118	Dermatitis, Allergic Contact	13%
119	Toxic Epidermal Necrolysis	12.9%
120	Stevens-Johnson Syndrome	12.9%
121	Tinea Capitis	12.4%
122	Onychomycosis	12.4%
123	Keratosis	12.4%
124	Ecthyma	12.2%
125	Granuloma Annulare	12%
126	Acantholysis	11.9%
127	Breast Cyst	11.9%
128	Pemphigoid, Benign Mucous Membrane	11.9%
129	Pemphigus	11.9%
130	Piedra	11.9%
131	Sunburn	11.9%
132	Argyria	11.8%
133	Hirsutism	11.8%
134	Lactation Disorder	11.8%
135	Mastitis	11.8%
136	Urticaria	11.8%
137	Adiposis Dolorosa	11.7%
138	Pruritus Vulvae	11.7%
139	Mastocytoma	11.7%
140	Pruritus Ani	11.7%
141	Diaper Rash	11.5%
142	Osteogenesis Imperfecta	11.5%
143	Angioedemas, Hereditary	11.2%
144	Menkes Kinky Hair Syndrome	10.4%
145	Neoplastic Syndromes, Hereditary	10.3%
146	Marfan Syndrome	10%
147	Dermatomycoses	9.9%
148	Mucocutaneous Lymph Node Syndrome	9.9%
149	Skin Diseases, Bacterial	9.9%
150	CHARGE Syndrome	9.9%
151	Multiple Epiphyseal Dysplasia	9.9%
152	Osteochondrodysplasias	9.9%
153	Pelger-Huet Anomaly	9.9%
154	Werner Syndrome	9.9%
155	Myasthenic Syndromes, Congenital	9.9%
156	Drug Eruptions	9.8%
157	Lipodystrophy	9.8%
158	Livedo Reticularis	9.8%
159	Malignant Atrophic Papulosis	9.8%
160	Keratoderma, Palmoplantar	9.8%
161	Cystic Fibrosis	9.8%
162	Hidradenitis Suppurativa	9.8%
163	Polyarteritis Nodosa	9.7%
164	Takayasu Arteritis	9.7%
165	Erythema Chronicum Migrans	9.7%
166	Lichen Planus	9.7%
167	Melanosis	9.7%
168	Chloasma	9.7%
169	Pityriasis Rosea	9.7%
170	Pityriasis Rubra Pilaris	9.7%
171	Vitiligo	9.7%
172	Lichen Nitidus	9.7%
173	Aicardi's syndrome	9.3%
174	Dwarfism	8.6%
175	Tinea Pedis	8.4%
176	Anemia, Sickle Cell	8.4%
177	Thalassemia	8.4%
178	Muscular Dystrophy, Duchenne	8.4%
179	Collagen Diseases	8.3%
180	Mixed Connective Tissue Disease	8.3%
181	Mucinoses	8.3%
182	Muscular Dystrophy	8.2%
183	Beckwith-Wiedemann Syndrome	8.2%
184	Wolf-Hirschhorn Syndrome	8.2%
185	Fragile X Syndrome	8%
186	Alopecia	7.9%
187	Sweating, Gustatory	7.9%
188	Androgenetic Alopecia	7.9%
189	Auriculotemporal Syndrome	7.9%
190	Lice Infestations	7.8%
191	Varicose Ulcer	7.8%
192	Breast Neoplasms, Male	7.8%
193	Triple Negative Breast Neoplasms	7.8%
194	Mycetoma	7.8%
195	Galactorrhea	7.7%
196	Peutz-Jeghers Syndrome	7.7%
197	Deformity	7.7%
198	Cockayne Syndrome	7.7%
199	Familial Mediterranean Fever	7.3%
200	Mucopolysaccharidosis II	7.3%
201	Acanthosis Nigricans	7.2%
202	Alopecia Areata	7.2%
203	Lentigo	7.2%
204	Autoimmune Lymphoproliferative Syndrome	7.2%
205	Smith-Magenis syndrome	7.1%
206	Cri-du-Chat Syndrome	7%
207	Down Syndrome	7%
208	Trisomy 21	7%
209	Cartilage Diseases	6.9%
210	Rheumatism	6.9%
211	Chondromalacia	6.9%
212	Alstrom Syndrome	6.8%
213	Lupus Erythematosus, Systemic	6.7%
214	Overlap syndrome	6.7%
215	Homocystinuria	6.6%
216	Larva Migrans	6.6%
217	Leishmaniasis	6.6%
218	Molluscum Contagiosum	6.6%
219	Angioedema	6.6%
220	Wiskott-Aldrich Syndrome	6.5%
221	Onchocerciasis	6.5%
222	Chromoblastomycosis	6.5%
223	Dermatophytosis	6.5%
224	Sporotrichosis	6.5%
225	Tinea	6.5%
226	Tinea Versicolor	6.5%
227	Trichophytosis	6.5%
228	Hyalohyphomycosis	6.5%
229	Papillon-Lefevre Disease	6.5%
230	Acute Generalized Exanthematous Pustulosis	6.5%
231	Rett Syndrome	6.4%
232	Kartagener Syndrome	6.4%
233	Holoprosencephaly	6.2%
234	Fetal Diseases	6.2%
235	Prader-Willi Syndrome	6.1%
236	Kallmann Syndrome	6%
237	Lichen Planus, Oral	5.9%
238	Amino Acid Metabolism, Inborn Errors	5.9%
239	Carbohydrate Metabolism, Inborn Errors	5.9%
240	Metal Metabolism, Inborn Errors	5.9%
241	Progeria	5.9%
242	Lysosomal Storage Diseases	5.9%
243	Cytochrome-c Oxidase Deficiency	5.9%
244	Peroxisomal Disorders	5.9%
245	Myotonic Dystrophy	5.9%
246	Giant Cell Arteritis	5.8%
247	Temporal Arteritis	5.8%
248	CREST Syndrome	5.7%
249	Warts	5.7%
250	Candidiasis, Chronic Mucocutaneous	5.6%
251	Cutaneous Candidiasis	5.6%
252	Polycystic Kidney Diseases	5.6%
253	Williams Syndrome	5.6%
254	Erysipelas	5.6%
255	Rubinstein-Taybi Syndrome	5.6%
256	Serum Sickness	5.6%
257	Staphylococcal Skin Infections	5.6%
258	Erythrasma	5.5%
259	Carcinoma, Lobular	5.5%
260	Arthritis, Psoriatic	5.5%
261	Sickle Cell Trait	5.5%
262	Dupuytren Contracture	5.5%
263	Neuronal Ceroid-Lipofuscinoses	5.5%
264	Tuberous Sclerosis	5.5%
265	Primary Ciliary Dyskinesia	5.4%
266	Smith-Lemli-Opitz Syndrome	5.4%
267	Mucopolysaccharidosis III	5.2%
268	Noonan Syndrome	5.1%
269	Retinal Dysplasia	5.1%
270	Aniridia	5%
271	Ataxia Telangiectasia	5%
272	Retinitis Pigmentosa	4.9%
273	Pigmentary retinopathy	4.9%
274	Hepatolenticular Degeneration	4.9%
275	Chronic granulomatous disease	4.9%
276	Scleromyxedema	4.9%
277	Amyloid Neuropathies, Familial	4.9%
278	Leishmaniasis, Cutaneous	4.9%
279	Welander Distal Myopathy	4.9%
280	Eczema Herpeticum	4.9%
281	Adrenoleukodystrophy	4.8%
282	Fusariosis	4.8%
283	Cellulitis	4.7%
284	Refsum Disease	4.6%
285	Acute Chest Syndrome	4.4%
286	Blastomycosis	4.4%
287	HIV-Associated Lipodystrophy Syndrome	4.3%
288	Duane Retraction Syndrome	4.3%
289	Fabry Disease	4.3%
290	Galactosemias	4.3%
291	Urea Cycle Disorders, Inborn	4.3%
292	Tyrosinemias	4.3%
293	Meconium Aspiration Syndrome	4.2%
294	Myotonia Congenita	4.2%
295	Thrombasthenia	4.2%
296	Antithrombin III Deficiency	4.2%
297	Protein C Deficiency	4.2%
298	Brain Diseases, Metabolic, Inborn	4.2%
299	Afibrinogenemia	4.2%
300	Dystonia Musculorum Deformans	4.2%
301	Factor VII Deficiency	4.2%
302	Factor X Deficiency	4.2%
303	Factor XII Deficiency	4.2%
304	Hemophilia A	4.2%
305	Activated Protein C Resistance	4.2%
306	Factor II deficiency	4.2%
307	Factor VIII Deficiency	4.2%
308	Factor V deficiency	4.2%
309	Factor XI Deficiency	4.2%
310	Hypoprothrombinemias	4.2%
311	Epidermodysplasia Verruciformis	4.2%
312	Herpes Labialis	4.2%
313	Fanconi Anemia	4.2%
314	Diabetic Foot	4.2%
315	Lafora Disease	4.2%
316	Unverricht-Lundborg Syndrome	4.2%
317	Anemia, Diamond-Blackfan	4.1%
318	Abdominal Cramps	4.1%
319	Abnormalities, Drug-Induced	4.1%
320	Amniotic Band Syndrome	4.1%
321	Asphyxia Neonatorum	4.1%
322	Infant, Premature, Diseases	4.1%
323	Situs Inversus	4.1%
324	Infantile Colic	4.1%
325	Staphylococcal Scalded Skin Syndrome	4.1%
326	Hereditary Angioedema Type III	4%
327	Hereditary Angioedema Types I and II	4%
328	Rhinoscleroma	4%
329	Mesenteric Panniculitis	4%
330	Panniculitis, Peritoneal	4%
331	Tietze's Syndrome	4%
332	Orbital Cellulitis	4%
333	Myxoid cyst	4%
334	Canavan Disease	4%
335	Alexander Disease	4%
336	Myxedema	3.9%
337	Glycogen storage disease type II	3.9%
338	Optic Atrophy, Hereditary, Leber	3.9%
339	Alkaptonuria	3.9%
340	Glycogen Storage Disease	3.9%
341	Hypophosphatasia	3.9%
342	Propionic acidemia	3.9%
343	Dihydropyrimidine Dehydrogenase Deficiency	3.9%
344	Cystinosis	3.9%
345	Hyperphosphaturia	3.9%
346	Multiple Endocrine Neoplasia	3.8%
347	Laryngomalacia	3.8%
348	Mobius Syndrome	3.8%
349	Pectus carinatum	3.8%
350	Zellweger Syndrome	3.8%
351	Congenital Hypothyroidism	3.7%
352	Condylomata Acuminata	3.7%
353	Polycystic Kidney, Autosomal Dominant	3.7%
354	Furunculosis	3.7%
355	furuncle	3.7%
356	Impetigo	3.6%
357	Classical Lissencephalies and Subcortical Band Heterotopias	3.5%
358	Eye Abnormalities	3.4%
359	Cardiovascular Abnormalities	3.4%
360	carbuncle	3.4%
361	Leigh Disease	3.4%
362	Lymphatic Abnormalities	3.4%
363	Congenital Microtia	3.4%
364	Osteochondritis	3.4%
365	Polymyalgia Rheumatica	3.4%
366	Anemia, Neonatal	3.3%
367	Persistent Fetal Circulation Syndrome	3.3%
368	Congenital diaphragmatic hernia	3.3%
369	Umbilical hernia	3.3%
370	Basal Cell Nevus Syndrome	3.3%
371	Keloid	3.2%
372	Charcot-Marie-Tooth Disease	3.2%
373	Antley-Bixler Syndrome Phenotype	3.2%
374	Hypolipoproteinemias	3.2%
375	Hyperlipidemia, Familial Combined	3.2%
376	Hyperlipoproteinemia Type III	3.2%
377	Gaucher Disease	3%
378	Huntington Disease	2.9%
379	Urogenital Abnormalities	2.9%
380	Glycogen Storage Disease Type I	2.9%
381	Glycogen Storage Disease Type V	2.9%
382	Carbamoyl-Phosphate Synthase I Deficiency Disease	2.9%
383	Rheumatoid Arthritis	2.9%
384	Juvenile arthritis	2.9%
385	Neonatal Abstinence Syndrome	2.8%
386	Familial Periodic Paralysis	2.8%
387	Bronchomalacia	2.8%
388	Tracheomalacia	2.8%
389	Lactose Intolerance	2.8%
390	Lupus Nephritis	2.8%
391	Hyperhomocysteinemia	2.8%
392	Fetal Growth Retardation	2.8%
393	Renal Aminoacidurias	2.8%
394	Fanconi Syndrome	2.8%
395	Pseudohypoaldosteronism	2.8%
396	Liddle Syndrome	2.8%
397	Fetal Hypoxia	2.7%
398	Congenital nystagmus	2.7%
399	Fetal Alcohol Spectrum Disorders	2.7%
400	Hyperlipoproteinemia Type IV	2.7%
401	Hyperlipoproteinemia Type V	2.7%
402	Toxoplasmosis, Congenital	2.7%
403	Anencephaly	2.7%
404	Syphilis, Congenital	2.7%
405	Nephroblastoma	2.7%
406	Tay-Sachs Disease	2.5%
407	Gout	2.5%
408	Niemann-Pick Disease, Type C	2.5%
409	Hydrops Fetalis	2.5%
410	Multiple Endocrine Neoplasia Type 1	2.4%
411	Pseudohypoparathyroidism	2.4%
412	Prune Belly Syndrome	2.4%
413	Twins, Conjoined	2.4%
414	Waardenburg Syndrome	2.4%
415	Friedreich Ataxia	2.4%
416	Adenomatous Polyposis Coli	2.4%
417	Renal tubular acidosis	2.4%
418	Klinefelter Syndrome	2.4%
419	Hypoalphalipoproteinemias	2.4%
420	Congenital Hyperinsulinism	2.4%
421	Chorioamnionitis	2.4%
422	Maxillofacial Abnormalities	2.4%
423	Dural Arteriovenous Fistula	2.4%
424	Dextrocardia	2.3%
425	Turner Syndrome	2.2%
426	Rheumatoid Nodule	2.2%
427	Hypokalemic periodic paralysis	2.1%
428	Abnormalities, Radiation-Induced	2.1%
429	Cystinuria	2.1%
430	Anophthalmos	2%
431	Anus, Imperforate	2%
432	Hydranencephaly	2%
433	Microphthalmos	2%
434	Neural Tube Defects	2%
435	Paralysis, Obstetric	2%
436	Retinopathy of Prematurity	2%
437	Tethered Cord Syndrome	2%
438	Iniencephaly	2%
439	Craniorachischisis	2%
440	Limb Deformities, Congenital	2%
441	Exencephaly	2%
442	Septo-Optic Dysplasia	2%
443	Craniofacial Abnormalities	2%
444	Cortical Dysplasia	2%
445	Malformations of Cortical Development	2%
446	Anorectal Malformations	2%
447	Bloom Syndrome	2%
448	Bronchopulmonary Dysplasia	1.9%
449	Glycosuria, Renal	1.9%
450	Familial Hypophosphatemic Rickets	1.9%
451	Scimitar Syndrome	1.9%
452	Felty Syndrome	1.9%
453	Arthritis, Gouty	1.8%
454	Ophthalmia Neonatorum	1.8%
455	Blepharophimosis	1.7%
456	Laryngostenosis	1.7%
457	Mouth Abnormalities	1.7%
458	Respiratory Distress Syndrome, Newborn	1.7%
459	Esophageal Atresia	1.7%
460	Intestinal Atresia	1.7%
461	Horseshoe Kidney	1.7%
462	Pectus excavatum	1.7%
463	Klippel-Feil Syndrome	1.6%
464	Gastroschisis	1.6%
465	Synostosis	1.6%
466	Lymphangiectasis, Intestinal	1.6%
467	Rheumatoid Vasculitis	1.6%
468	Craniosynostosis	1.6%
469	Syndactyly	1.6%
470	Brachycephaly	1.6%
471	Microcephaly	1.6%
472	Macrocephaly	1.6%
473	MELAS Syndrome	1.6%
474	Denys-Drash Syndrome	1.6%
475	Acrocephalosyndactylia	1.5%
476	Arthrogryposis	1.4%
477	Choanal Atresia	1.4%
478	Tracheobronchomegaly	1.4%
479	Sicca Syndrome	1.4%
480	Sjogren's Syndrome	1.4%
481	Laryngocele	1.4%
482	Choledochal Cyst	1.4%
483	Hermaphroditism	1.4%
484	Disorders of Sex Development	1.4%
485	Cryptorchidism	1.4%
486	Hypospadias	1.4%
487	Central Nervous System Cysts	1.4%
488	Dandy-Walker Syndrome	1.4%
489	Leukomalacia, Periventricular	1.4%
490	POEMS Syndrome	1.4%
491	Nesidioblastosis	1.4%
492	Lupus Vasculitis, Central Nervous System	1.4%
493	Porencephaly	1.4%
494	Amelia	1.3%
495	Arachnodactyly	1.3%
496	Ectopia Cordis	1.3%
497	Ectromelia	1.3%
498	Hemimelia	1.3%
499	Meningomyelocele	1.3%
500	Phocomelia	1.3%
501	Sirenomelia	1.3%
502	Spina Bifida	1.3%
503	Polydactyly	1.3%
504	Brachydactyly	1.3%
505	Plagiocephaly	1.3%
506	Lower Extremity Deformities, Congenital	1.3%
507	Upper Extremity Deformities, Congenital	1.3%
508	Single umbilical artery	1.3%
509	Cleft Palate	1.3%
510	Jaw Abnormalities	1.3%
511	Bladder Exstrophy	1.2%
512	Epispadias	1.2%
513	Multicystic Dysplastic Kidney	1.2%
514	Poland Syndrome	1.2%
515	Kernicterus	1.1%
516	Aortic coarctation	1.1%
517	Cor Triatriatum	1.1%
518	Coronary Vessel Anomalies	1.1%
519	Dental Enamel Hypoplasia	1.1%
520	Patent ductus arteriosus	1.1%
521	Ebstein Anomaly	1.1%
522	Heart Septal Defects	1.1%
523	Hyaline Membrane Disease	1.1%
524	Hypodontia	1.1%
525	Macrostomia	1.1%
526	Meningocele	1.1%
527	Microstomia	1.1%
528	Tetralogy of Fallot	1.1%
529	Transposition of Great Vessels	1.1%
530	Hypoplastic Left Heart Syndrome	1.1%
531	May-Thurner Syndrome	1.1%
532	Encephalocele	1.1%
533	Craniofacial Dysostosis	1.1%
534	Wolff-Parkinson-White Syndrome	1.1%
535	Micrognathism	1%
536	Pierre Robin Syndrome	1%
537	Dermal Sinus	1%
538	Spina Bifida Cystica	1%
539	Spina Bifida Occulta	1%
540	Lissencephaly	1%
541	Polymicrogyria	1%
542	Pachygyria	1%
543	Schizencephaly	1%
544	Periventricular Nodular Heterotopia	1%
545	Long QT Syndrome	0.9%
546	Platybasia	0.9%
547	Tricuspid Atresia	0.9%
548	Arrhythmogenic Right Ventricular Dysplasia	0.9%
549	Gonadal Dysgenesis	0.9%
550	Adrenogenital Syndrome	0.9%
551	Ovotesticular Disorders of Sex Development	0.9%
552	Retrognathia	0.9%
553	Hyperandrogenism	0.9%
554	Prognathism	0.8%
555	Aortopulmonary Septal Defect	0.8%
556	Double Outlet Right Ventricle	0.8%
557	Endocardial Cushion Defects	0.8%
558	Myocardial bridging	0.8%
559	Aorticopulmonary Septal Defect	0.8%
560	Mandibulofacial Dysostosis	0.7%
561	Romano-Ward Syndrome	0.7%
562	Truncus Arteriosus, Persistent	0.7%
563	Goldenhar Syndrome	0.7%
564	Talipes	0.6%
565	Arteriovenous fistula	0.5%
566	Congenital clubfoot	0.5%
567	Vertical Talus	0.5%

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