MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Lafora Disease

(UMLS:C0751783)

Definition:: A form of stimulus sensitive MYOCLONIC EPILEPSY inherited as an autosomal recessive condition. The most common presenting feature is a single seizure in the second decade of life. This is followed by progressive myoclonus, myoclonic seizures, tonic-clonic seizures, focal occipital seizures, intellectual decline, and severe motor and coordination impairments. Most affected individuals do not live past the age of 25 years. Concentric amyloid (Lafora) bodies are found in neurons, liver, skin, bone, and muscle (From Menkes, Textbook of Childhood Neurology, 5th ed, pp111-110).
UMLS ID:: C0751783
MeSH ID:: D020192

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.490.375.130.650.500|C10.228.140.490.493.063.650.500|C10.574.500.529

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.400.480

Synonym(s)

Lafora Disease

LAFORA DISEASE

Lafora

Lafora body disease

Lafora disease

Lafora's myoclonic epilepsy

MYOCLONIC EPILEPSY OF LAFORA

lafora body disease

lafora disease

10.

lafora's disease

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Penicillamine		7445978	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Unverricht-Lundborg Syndrome	54.7%
2	Dystonia Musculorum Deformans	36.1%
3	Juvenile Myoclonic Epilepsy	33.6%
4	Huntington Disease	30.8%
5	Multiple System Atrophy	28.8%
6	Epilepsy, Temporal Lobe	28.1%
7	Epilepsy, Rolandic	28.1%
8	Benign Rolandic Epilepsy	28.1%
9	Hepatolenticular Degeneration	27.2%
10	Myotonia Congenita	26.8%
11	Encephalomyelitis	26.1%
12	Canavan Disease	25.5%
13	Alexander Disease	25.5%
14	Meningoencephalitis	25.2%
15	Cockayne Syndrome	25%
16	Epilepsy, Post-Traumatic	24.5%
17	Neuronal Ceroid-Lipofuscinoses	24.4%
18	Tuberous Sclerosis	24.3%
19	Myotonic Dystrophy	24.1%
20	Lewy Body Disease	24%
21	Epilepsies, Partial	23.7%
22	Simple Partial Seizures	23.7%
23	Epilepsy, Reflex	23.7%
24	Prion Diseases	23.7%
25	Subdural Effusion	23.5%
26	Friedreich Ataxia	23.5%
27	Dandy-Walker Syndrome	22.9%
28	Motor Neuron Disease	22.5%
29	Pneumocephalus	22.4%
30	Ocular Motility Disorders	22.1%
31	Cyclophoria	22.1%
32	Parkinson Disease	22.1%
33	Akinetic Mutism	22%
34	Anoxic Encephalopathy	22%
35	Basal Ganglia Diseases	22%
36	Brain Damage, Chronic	22%
37	Cerebellar Diseases	22%
38	Encephalitis	22%
39	Encephalomalacia	22%
40	Hydrocephalus	22%
41	Congenital Hydrocephalus	22%
42	Hypothalamic Diseases	22%
43	Thalamic Diseases	22%
44	Intracranial Hypertension	22%
45	Leukoencephalopathy	22%
46	Neuroaxonal Dystrophies	22%
47	Headache Disorders	22%
48	Intracranial Hypotension	22%
49	Brain Edema	22%
50	Brain Hypoxia	22%
51	Aqueductal Stenosis	22%
52	Amyloid Neuropathies, Familial	21.9%
53	Charcot-Marie-Tooth Disease	21.3%
54	Subacute Combined Degeneration	21.1%
55	Amyotrophic Lateral Sclerosis	20.9%
56	Brain Abscess	20.8%
57	Alstrom Syndrome	20.8%
58	Meningitis	20.3%
59	Movement Disorders	20.3%
60	Pachymeningitis	20.3%
61	Spinal Cord Diseases	20.3%
62	Brain Injuries	19.6%
63	Brain Neoplasms	19.6%
64	Spinal Muscular Atrophy	19.3%
65	Progressive Muscular Atrophy	19.3%
66	Parkinsonian Disorders	19.2%
67	Refsum Disease	19%
68	Stiff-Person Syndrome	18.9%
69	Dementia, Vascular	18.7%
70	Brain Diseases, Metabolic	18.6%
71	Cerebrovascular Disorders	18.6%
72	Cerebrovascular Insufficiency	18.6%
73	Dementia	18.6%
74	Progressive supranuclear palsy	18.4%
75	Myelitis	18.2%
76	Marchiafava-Bignami Disease	18.1%
77	Cranial nerve diseases	17.8%
78	Demyelinating Diseases	17.8%
79	Demyelination	17.8%
80	Neuromuscular Diseases	17.8%
81	Chronobiology Disorders	17.8%
82	Epidural Abscess	17.6%
83	Central Nervous System Infection	17.5%
84	Basal Ganglia Cerebrovascular Disease	17.4%
85	Tauopathies	17.3%
86	Striatonigral Degeneration	17.2%
87	Brain Death	17.1%
88	Leukomalacia, Periventricular	16.9%
89	Optic Atrophy, Hereditary, Leber	16.8%
90	Fragile X Syndrome	16.4%
91	Presenile dementia	16.3%
92	Senile dementia	16.3%
93	Limbic Encephalitis	16.2%
94	Posterior Leukoencephalopathy Syndrome	16.1%
95	Posterior reversible encephalopathy syndrome	16.1%
96	Amblyopia	16%
97	Adrenoleukodystrophy	15.7%
98	Rett Syndrome	15.5%
99	Neuroleptic Malignant Syndrome	15.5%
100	Myelinolysis, Central Pontine	15.5%
101	Meige Syndrome	15.3%
102	Cerebral Ventriculitis	15.3%
103	Shy-Drager Syndrome	15.3%
104	Trauma, Nervous System	15.3%
105	Spinal Cord Injuries	15.1%
106	Nervous System Neoplasms	14.9%
107	Neurologic Manifestations	14.9%
108	Neurotoxicity Syndromes	14.9%
109	Restless Legs Syndrome	14.7%
110	Asterixis	14.6%
111	Ballismus	14.6%
112	Menkes Kinky Hair Syndrome	14.5%
113	Myasthenic Syndromes, Congenital	14.4%
114	Paraneoplastic Cerebellar Degeneration	14.2%
115	Myelitis, Transverse	14.2%
116	Smith-Magenis syndrome	14.2%
117	Polyradiculoneuropathy	14%
118	Polyradiculoneuritis	14%
119	Opsoclonus-Myoclonus Syndrome	13.9%
120	Ophthalmoplegic Migraine	13.9%
121	Vascular Headaches	13.9%
122	Hypoxia-Ischemia, Brain	13.8%
123	Poliomyelitis	13.8%
124	Aicardi's syndrome	13.7%
125	Epilepsy, Complex Partial	13.7%
126	Cerebellar Neoplasms	13.5%
127	Amnesia, Transient Global	13.5%
128	Leukoencephalopathy, Progressive Multifocal	13.5%
129	Progressive bulbar palsy	13.3%
130	Bulbar palsy	13.3%
131	Chronic Fatigue Syndrome	13.3%
132	Creutzfeldt-Jakob disease	13.2%
133	Mucopolysaccharidosis II	13%
134	Sleep Wake Disorders	13%
135	Ataxia Telangiectasia	12.9%
136	Epilepsy, Generalized	12.8%
137	Lambert-Eaton Myasthenic Syndrome	12.8%
138	Myoclonic Epilepsy	12.7%
139	Brain Diseases, Metabolic, Inborn	12.6%
140	Paraneoplastic Encephalomyelitis	12.5%
141	Miller Fisher Syndrome	12.4%
142	Autonomic Dysreflexia	12.4%
143	Complex Regional Pain Syndromes	12.4%
144	Meningitis, Bacterial	12.3%
145	Meningitis, Fungal	12.3%
146	Leukoencephalitis, Acute Hemorrhagic	12.3%
147	Scrapie	12.2%
148	Lupus Vasculitis, Central Nervous System	12.2%
149	Cerebral Palsy	12.1%
150	Pseudotumor Cerebri	12.1%
151	Hypertensive Encephalopathy	12.1%
152	Headache Disorders, Primary	12.1%
153	Headache Disorders, Secondary	12.1%
154	Medication overuse headache	12.1%
155	Vasculitis, Central Nervous System	12.1%
156	Spinal Cord Neoplasms	11.6%
157	Akathisia, Drug-Induced	11.4%
158	MPTP Poisoning	11.4%
159	Muscular Dystrophy, Duchenne	11.3%
160	Encephalomyelitis, Acute Disseminated	11.3%
161	Brain Injuries, Diffuse	11.1%
162	Traumatic Brain Injury	11.1%
163	Cerebellar Ataxia	11%
164	Supratentorial Neoplasms	11%
165	Muscular Dystrophy	10.9%
166	Central Nervous System Cysts	10.9%
167	Arachnoiditis	10.9%
168	Aseptic Meningitis	10.9%
169	Syringomyelia	10.9%
170	Essential Tremor	10.9%
171	Familial Tremor	10.9%
172	Pneumorrhachis	10.9%
173	Writer's Cramp	10.9%
174	Brain Hemorrhage, Traumatic	10.7%
175	Peripheral Nerve Injuries	10.7%
176	Dyskinesia, Drug-Induced	10.7%
177	Myasthenia Gravis	10.6%
178	Pituitary Diseases	10.5%
179	CHARGE Syndrome	10.4%
180	Persistent Vegetative State	10.3%
181	Guillain-Barre Syndrome	10.3%
182	Cri-du-Chat Syndrome	10.3%
183	Down Syndrome	10.3%
184	Trisomy 21	10.3%
185	Neoplastic Syndromes, Hereditary	10.2%
186	Toxoplasmosis, Cerebral	10.2%
187	Holoprosencephaly	10.2%
188	Cystic Fibrosis	10.2%
189	Carotid Artery Diseases	10.1%
190	Brain Ischemia	10.1%
191	Cerebrovascular accident	10.1%
192	Kluver-Bucy Syndrome	10.1%
193	Vasospasm, Intracranial	10.1%
194	Intracranial Arterial Diseases	10.1%
195	Hydranencephaly	10%
196	Neural Tube Defects	10%
197	Tethered Cord Syndrome	10%
198	Iniencephaly	10%
199	Craniorachischisis	10%
200	Exencephaly	10%
201	Septo-Optic Dysplasia	10%
202	Cortical Dysplasia	10%
203	Malformations of Cortical Development	10%
204	Ichthyosis, X-Linked	10%
205	Carotid Artery Injuries	10%
206	Multiple Epiphyseal Dysplasia	9.9%
207	Osteochondrodysplasias	9.9%
208	Pelger-Huet Anomaly	9.9%
209	Werner Syndrome	9.9%
210	Albinism	9.9%
211	Fabry Disease	9.8%
212	Anemia, Sickle Cell	9.8%
213	Thalassemia	9.8%
214	Basal Ganglia Hemorrhage	9.6%
215	Sleep Disorders, Circadian Rhythm	9.5%
216	Galactosemias	9.4%
217	Urea Cycle Disorders, Inborn	9.4%
218	Tyrosinemias	9.4%
219	Dysautonomia	9.4%
220	Vagus Nerve Disorder	9.4%
221	Glossopharyngeal Neuralgia	9.4%
222	Abducens Nerve Diseases	9.4%
223	Heavy Metal Poisoning, Nervous System	9.4%
224	Neuromuscular Junction Diseases	9.4%
225	Trochlear Nerve Diseases	9.4%
226	Peripheral Nervous System Diseases	9.4%
227	Beckwith-Wiedemann Syndrome	9.4%
228	Wolf-Hirschhorn Syndrome	9.4%
229	Botulism	9.3%
230	Central Nervous System Fungal Infections	9.2%
231	Conus Medullaris Syndrome	9.2%
232	Spinal Cord Vascular Diseases	9.2%
233	Nail-Patella Syndrome	9.2%
234	Prader-Willi Syndrome	9.2%
235	Pituitary Apoplexy	9.2%
236	Frontotemporal dementia	9%
237	Brain Infarction	9%
238	Pituitary Adenoma	9%
239	Pituitary Neoplasms	9%
240	Olfactory Nerve Injuries	8.9%
241	Dural Arteriovenous Fistula	8.8%
242	Dwarfism	8.7%
243	Neuromyelitis Optica	8.7%
244	Reye Syndrome	8.7%
245	MELAS Syndrome	8.7%
246	Causalgia	8.7%
247	Intracranial Embolism and Thrombosis	8.7%
248	Hepatic Encephalopathy	8.7%
249	Mitochondrial Encephalomyopathies	8.7%
250	Williams Syndrome	8.6%
251	Osteogenesis Imperfecta	8.5%
252	Central Cord Syndrome	8.5%
253	Duane Retraction Syndrome	8.4%
254	Myoclonic Epilepsies, Progressive	8.4%
255	Rubinstein-Taybi Syndrome	8.4%
256	Chorea	8.3%
257	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	8.2%
258	Homocystinuria	8.2%
259	Leigh Disease	8.1%
260	Classical Lissencephalies and Subcortical Band Heterotopias	8.1%
261	Myopathy	8.1%
262	Optic Neuropathy	8.1%
263	Kartagener Syndrome	8.1%
264	Central Nervous System Bacterial Infections	8%
265	Horner Syndrome	8%
266	Glycogen storage disease type II	8%
267	Tuberculosis, Meningeal	7.9%
268	Facial Nerve Diseases	7.9%
269	Craniocerebral Trauma	7.9%
270	Parasomnia	7.9%
271	Dyssomnias	7.9%
272	Facial Nerve Injuries	7.9%
273	Vestibulocochlear Nerve Diseases	7.8%
274	Decerebrate State	7.8%
275	Hemiparesis	7.8%
276	Meningism	7.8%
277	Paresis	7.8%
278	Seizures	7.8%
279	Sensation Disorders	7.8%
280	Central Nervous System Neoplasms	7.8%
281	Complex partial seizures	7.8%
282	Monoparesis	7.8%
283	Neurogenic Inflammation	7.8%
284	Gait Disorders, Neurologic	7.8%
285	Neuromuscular Manifestations	7.8%
286	Wiskott-Aldrich Syndrome	7.8%
287	Familial Mediterranean Fever	7.8%
288	Sweating, Gustatory	7.8%
289	Auriculotemporal Syndrome	7.8%
290	Auditory Perceptual Disorders	7.8%
291	Zellweger Syndrome	7.7%
292	Multiple Sclerosis	7.7%
293	Marfan Syndrome	7.6%
294	Mobius Syndrome	7.5%
295	Kernicterus	7.5%
296	Autoimmune Lymphoproliferative Syndrome	7.5%
297	Angioedemas, Hereditary	7.4%
298	Reflex Sympathetic Dystrophy	7.3%
299	Nocturnal Myoclonus Syndrome	7.3%
300	Ectodermal Dysplasia	7.3%
301	Aplasia Cutis Congenita	7.3%
302	Welander Distal Myopathy	7.3%
303	Post-Traumatic Headache	7.2%
304	Tension Headache	7.2%
305	Migraine Disorders	7.2%
306	Abdominal Migraine	7.2%
307	Status Migrainosus	7.2%
308	Cervicogenic Headache	7.2%
309	Sickle Cell Trait	7.2%
310	Smith-Lemli-Opitz Syndrome	7.1%
311	Jet Lag Syndrome	7.1%
312	Anencephaly	7.1%
313	Familial Periodic Paralysis	7.1%
314	Myasthenia Gravis, Autoimmune, Experimental	7.1%
315	Vertebral Artery Dissection	7%
316	Pupil Disorders	6.9%
317	Neurobehavioral Manifestations	6.9%
318	Torticollis	6.9%
319	Diffuse Axonal Injury	6.9%
320	Brain Stem Neoplasms	6.9%
321	Ophthalmoplegia	6.8%
322	External Ophthalmoplegia	6.8%
323	Wernicke Encephalopathy	6.8%
324	Deformity	6.8%
325	AIDS Dementia Complex	6.8%
326	Uveomeningoencephalitic Syndrome	6.7%
327	Moyamoya Disease	6.7%
328	Sturge-Weber Syndrome	6.7%
329	Vertigo	6.7%
330	Alcohol-Induced Disorders, Nervous System	6.7%
331	Kallmann Syndrome	6.7%
332	Sjogren-Larsson Syndrome	6.6%
333	Putaminal Hemorrhage	6.6%
334	Carbamoyl-Phosphate Synthase I Deficiency Disease	6.6%
335	Amino Acid Metabolism, Inborn Errors	6.5%
336	Carbohydrate Metabolism, Inborn Errors	6.5%
337	Metal Metabolism, Inborn Errors	6.5%
338	Progeria	6.5%
339	Lysosomal Storage Diseases	6.5%
340	Cytochrome-c Oxidase Deficiency	6.5%
341	Peroxisomal Disorders	6.5%
342	Brain Concussion	6.5%
343	Polycystic Kidney Diseases	6.5%
344	Meningitis, Cryptococcal	6.5%
345	Lafora Disease	6.5%
346	Meningitis, Listeria	6.4%
347	Primary Ciliary Dyskinesia	6.4%
348	Meningitis, Haemophilus	6.4%
349	Meningitis, Pneumococcal	6.4%
350	Gaucher Disease	6.3%
351	Acrodynia	6.2%
352	Empty Sella Syndrome	6.1%
353	Hyperpituitarism	6.1%
354	Hypopituitarism	6.1%
355	Hypophysitis	6.1%
356	Vocal Cord Paralysis	6.1%
357	Meningomyelocele	6.1%
358	Spina Bifida	6.1%
359	Brain Contusion	6%
360	Cerebral Arterial Diseases	6%
361	Vertebrobasilar Insufficiency	6%
362	Basilar Artery Stenosis	6%
363	Vertebral Artery Stenosis	6%
364	Intracranial Hemorrhage, Hypertensive	6%
365	Transient Cerebral Ischemia	6%
366	Cerebral Infarction	6%
367	Brain Stem Infarctions	6%
368	Voice Disorders	6%
369	Voice Disturbance	6%
370	Retinal Dysplasia	6%
371	Infarction, Middle Cerebral Artery	6%
372	Infarction, Anterior Cerebral Artery	6%
373	Infarction, Posterior Cerebral Artery	6%
374	Subacute Sclerosing Panencephalitis	5.9%
375	Aniridia	5.9%
376	Acute Chest Syndrome	5.9%
377	Subarachnoid Hemorrhage, Traumatic	5.9%
378	Carotid Artery, Internal, Dissection	5.9%
379	Epidermolysis Bullosa	5.8%
380	Alice in Wonderland Syndrome	5.8%
381	Giant Cell Arteritis	5.7%
382	Temporal Arteritis	5.7%
383	Toxoplasmosis, Congenital	5.7%
384	Fetal Diseases	5.7%
385	Cutis Laxa	5.7%
386	Brachial Plexus Neuritis	5.7%
387	Neuralgic Amyotrophy	5.7%
388	Retinitis Pigmentosa	5.6%
389	Pigmentary retinopathy	5.6%
390	Porokeratosis	5.6%
391	Keratoderma, Palmoplantar	5.6%
392	Chronic granulomatous disease	5.6%
393	Tay-Sachs Disease	5.5%
394	Cerebrospinal Fluid Otorrhea	5.5%
395	Cerebrospinal Fluid Rhinorrhea	5.5%
396	Neuritis, Autoimmune, Experimental	5.5%
397	Gait Ataxia	5.5%
398	Niemann-Pick Disease, Type C	5.4%
399	Alcohol Withdrawal Seizures	5.4%
400	Neuritis	5.4%
401	Polyneuritis	5.4%
402	Radiculitis	5.4%
403	Polyneuropathy	5.4%
404	Mononeuritis	5.4%
405	Mononeuropathies	5.4%
406	Brachial Plexus Neuropathies	5.4%
407	Radiculopathy	5.4%
408	Mononeuropathy Multiplex	5.4%
409	Nerve Root Compression	5.4%
410	Mucopolysaccharidosis III	5.3%
411	Congenital nystagmus	5.3%
412	Tardive Dyskinesia	5.3%
413	Spinal Cord Ischemia	5.3%
414	Hyperphosphaturia	5.3%
415	Meningocele	5.2%
416	Encephalocele	5.2%
417	Tuberculosis, Central Nervous System	5.2%
418	Coma, Post-Head Injury	5.2%
419	Carotid Stenosis	5.2%
420	Intracranial Aneurysm	5.2%
421	Reflex, Abnormal	5.2%
422	Hyporeflexia	5.2%
423	Hyperreflexia	5.2%
424	Intracranial Arteriosclerosis	5.2%
425	Cerebral Atherosclerosis	5.2%
426	Subarachnoid Hemorrhage	5.2%
427	Cerebral Arteriosclerosis	5.2%
428	Cerebral Hemorrhage	5.2%
429	Cerebral Thrombosis	5.2%
430	Intracranial Embolism	5.2%
431	Intracranial Thrombosis	5.2%
432	Hypokalemic periodic paralysis	5.1%
433	Porphyrias, Hepatic	5%
434	Peutz-Jeghers Syndrome	4.9%
435	Thrombasthenia	4.9%
436	Antithrombin III Deficiency	4.9%
437	Protein C Deficiency	4.9%
438	Afibrinogenemia	4.9%
439	Factor VII Deficiency	4.9%
440	Factor X Deficiency	4.9%
441	Factor XII Deficiency	4.9%
442	Hemophilia A	4.9%
443	Activated Protein C Resistance	4.9%
444	Factor II deficiency	4.9%
445	Factor VIII Deficiency	4.9%
446	Factor V deficiency	4.9%
447	Factor XI Deficiency	4.9%
448	Hypoprothrombinemias	4.9%
449	Akathisia	4.9%
450	Restlessness	4.9%
451	Psychomotor Agitation	4.9%
452	Fanconi Anemia	4.9%
453	Alkaptonuria	4.8%
454	Glycogen Storage Disease	4.8%
455	Hypophosphatasia	4.8%
456	Propionic acidemia	4.8%
457	Dihydropyrimidine Dehydrogenase Deficiency	4.8%
458	Cystinosis	4.8%
459	Anemia, Diamond-Blackfan	4.8%
460	Multiple Sclerosis, Chronic Progressive	4.8%
461	Multiple Sclerosis, Relapsing-Remitting	4.8%
462	Tarsal Tunnel Syndrome	4.8%
463	Cauda Equina Syndrome	4.8%
464	Cluster Headache	4.8%
465	Migraine with Aura	4.8%
466	Familial Hemiplegic Migraine	4.8%
467	Chronic Paroxysmal Hemicrania	4.8%
468	SUNCT Syndrome	4.8%
469	Paroxysmal Hemicrania	4.8%
470	Polycystic Kidney, Autosomal Dominant	4.8%
471	Pseudoxanthoma Elasticum	4.8%
472	Choroid Plexus Papilloma	4.8%
473	Hyperkeratosis, Epidermolytic	4.7%
474	Neuroaspergillosis	4.5%
475	Myositis	4.5%
476	Optic Atrophy	4.5%
477	Optic Neuritis	4.5%
478	Papilledema	4.5%
479	Strabismus	4.5%
480	Tolosa-Hunt Syndrome	4.5%
481	Isaacs syndrome	4.5%
482	Arsenic Poisoning	4.5%
483	Myotonic Disorders	4.5%
484	Carotid Artery Thrombosis	4.5%
485	Diabetic Neuropathies	4.5%
486	Facial Injuries	4.5%
487	Facial Neuralgia	4.5%
488	Diabetic Amyotrophy	4.5%
489	Diabetic Autonomic Neuropathy	4.5%
490	Sleep Talking	4.5%
491	Manganese Poisoning	4.5%
492	Sleep Disorders, Intrinsic	4.5%
493	Orthostatic intolerance	4.5%
494	Lateral Medullary Syndrome	4.5%
495	Meconium Aspiration Syndrome	4.5%
496	Multiple Endocrine Neoplasia	4.5%
497	Optic Nerve Glioma	4.5%
498	Anosmia	4.5%
499	Ataxia	4.5%
500	Athetosis	4.5%
501	Catalepsy	4.5%
502	Dystonia	4.5%
503	Hemiplegia	4.5%
504	Locked-In Syndrome	4.5%
505	Meningeal Neoplasms	4.5%
506	Muscle Hypertonia	4.5%
507	Muscle hypotonia	4.5%
508	Myoclonus	4.5%
509	Myotonia	4.5%
510	Neuralgia	4.5%
511	Paraplegia	4.5%
512	Pseudobulbar Palsy	4.5%
513	Quadriplegia	4.5%
514	Spasm	4.5%
515	Spastic Paraplegia	4.5%
516	Status Epilepticus	4.5%
517	Taste Disorders	4.5%
518	Tremor	4.5%
519	Monoplegia	4.5%
520	Hypokinesia	4.5%
521	Paraparesis	4.5%
522	Bradykinesia	4.5%
523	Waxy flexibility	4.5%
524	Action Tremor	4.5%
525	Resting Tremor	4.5%
526	Dysosmia	4.5%
527	Quadriparesis	4.5%
528	Mercury Poisoning, Nervous System	4.5%
529	Olfaction Disorders	4.5%
530	Myokymia	4.5%
531	Lead Poisoning, Nervous System	4.5%
532	Vestibular Neuronitis	4.5%
533	Somatosensory Disorders	4.5%
534	Neuropathic pain	4.5%
535	Hyperkinesia	4.5%
536	Intention tremor	4.5%
537	Xeroderma Pigmentosum	4.4%
538	Congenital Hypothyroidism	4.4%
539	Dermatitis, Atopic	4.4%
540	Microcephaly	4.3%
541	Macrocephaly	4.3%
542	Antley-Bixler Syndrome Phenotype	4.3%
543	Gait Apraxia	4.3%
544	Carpal Tunnel Syndrome	4.2%
545	Dermal Sinus	4.2%
546	Spina Bifida Cystica	4.2%
547	Spina Bifida Occulta	4.2%
548	Lissencephaly	4.2%
549	Polymicrogyria	4.2%
550	Pachygyria	4.2%
551	Schizencephaly	4.2%
552	Periventricular Nodular Heterotopia	4.2%
553	Hypolipoproteinemias	4.2%
554	Papillon-Lefevre Disease	4.2%
555	Hyperlipidemia, Familial Combined	4.1%
556	neurofibroma	4.1%
557	Hyperlipoproteinemia Type III	4.1%
558	Xeroderma	4.1%
559	Sciatica	4.1%
560	Porencephaly	4.1%
561	Acoustic Neuroma	4.1%
562	Pseudorabies	4.1%
563	Hematoma, Subdural	4.1%
564	Hematoma, Epidural, Cranial	4.1%
565	Hyperprolactinemia	4%
566	Basal Cell Nevus Syndrome	4%
567	Glycogen Storage Disease Type I	4%
568	Glycogen Storage Disease Type V	4%
569	Subclavian Steal Syndrome	4%
570	Pick Disease of the Brain	4%
571	Hand-Arm Vibration Syndrome	4%
572	Abdominal Cramps	4%
573	Abnormalities, Drug-Induced	4%
574	Amniotic Band Syndrome	4%
575	Asphyxia Neonatorum	4%
576	Brain Diseases	4%
577	Infant, Premature, Diseases	4%
578	Situs Inversus	4%
579	Infantile Colic	4%
580	Vision Disorders	4%
581	Metamorphopsia	4%
582	Visual Impairment	4%
583	Behcet Syndrome	3.9%
584	West Nile Fever	3.9%
585	Neurosyphilis	3.9%
586	Fibromyalgia	3.9%
587	Optic Neuropathy, Ischemic	3.9%
588	Anterior Ischemic Optic Neuropathy	3.9%
589	Medial Tibial Stress Syndrome	3.9%
590	Facial Hemiatrophy	3.9%
591	Melkersson-Rosenthal Syndrome	3.9%
592	Mitochondrial Myopathies	3.9%
593	Anisocoria	3.9%
594	Confusion	3.9%
595	Facial paralysis	3.9%
596	Lethargy	3.9%
597	Memory Disorders	3.9%
598	Muscle Cramp	3.9%
599	Perceptual Disorders	3.9%
600	Psychomotor Disorders	3.9%
601	Tonic Pupil	3.9%
602	Eosinophilia-Myalgia Syndrome	3.9%
603	Anhedonia	3.9%
604	Disorientation	3.9%
605	Facial Paresis	3.9%
606	Memory Loss	3.9%
607	Hemisensory Neglect	3.9%
608	Dysacusis	3.9%
609	Sleep Bruxism	3.9%
610	Muscular Atrophy	3.8%
611	Respiratory Paralysis	3.8%
612	Tetany	3.8%
613	POEMS Syndrome	3.8%
614	Klinefelter Syndrome	3.7%
615	Lactose Intolerance	3.6%
616	Variegate Porphyria	3.6%
617	Acute intermittent porphyria	3.6%
618	Porphyria Cutanea Tarda	3.6%
619	Hyperhomocysteinemia	3.6%
620	Renal Aminoacidurias	3.6%
621	Fanconi Syndrome	3.6%
622	Pseudohypoaldosteronism	3.6%
623	Liddle Syndrome	3.6%
624	Hyperlipoproteinemia Type IV	3.6%
625	Hyperlipoproteinemia Type V	3.6%
626	Lyme Neuroborreliosis	3.5%
627	Acromegaly	3.5%
628	Cubital Tunnel Syndrome	3.4%
629	Cerebral Amyloid Angiopathy	3.4%
630	Hypoalphalipoproteinemias	3.4%
631	Sinus Thrombosis, Intracranial	3.4%
632	Consciousness Disorders	3.4%
633	Mental Retardation	3.4%
634	Muscle Weakness	3.4%
635	Depressed Level of Consciousness	3.4%
636	Mental deficiency	3.4%
637	Intellectual Disability	3.4%
638	Hydrops Fetalis	3.4%
639	Eye Abnormalities	3.4%
640	Cardiovascular Abnormalities	3.4%
641	Bell Palsy	3.4%
642	Turner Syndrome	3.4%
643	Catatonia	3.4%
644	Sciatic Neuropathy	3.4%
645	Ulnar Neuropathies	3.4%
646	Lesion of Sciatic Nerve	3.4%
647	Ulnar Neuritis	3.4%
648	Radial nerve compression	3.4%
649	Radial Tunnel Syndrome	3.4%
650	Peroneal Neuropathies	3.4%
651	Radial Neuropathy	3.4%
652	Median Neuropathy	3.4%
653	Sciatic Nerve Palsy	3.4%
654	Femoral Neuropathy	3.4%
655	Tibial Neuropathy	3.4%
656	Ulnar Nerve Palsy	3.4%
657	Postural Orthostatic Tachycardia Syndrome	3.4%
658	Radial nerve palsy	3.4%
659	Herpes Zoster Oticus	3.4%
660	Aphonia	3.4%
661	Sleep Deprivation	3.4%
662	Dysphonia	3.4%
663	Anterior Spinal Artery Syndrome	3.4%
664	Skin Abnormalities	3.3%
665	Lymphatic Abnormalities	3.3%
666	Congenital Microtia	3.3%
667	Anemia, Neonatal	3.3%
668	Persistent Fetal Circulation Syndrome	3.3%
669	Gout	3.3%
670	Congenital diaphragmatic hernia	3.3%
671	Umbilical hernia	3.3%
672	Multiple Endocrine Neoplasia Type 1	3.3%
673	Pseudohypoparathyroidism	3.3%
674	Nephroblastoma	3.3%
675	Renal tubular acidosis	3.2%
676	Cystinuria	3%
677	Myalgia	3%
678	Hematoma, Subdural, Intracranial	3%
679	Hematoma, Subdural, Chronic	3%
680	Hematoma, Subdural, Acute	3%
681	Familial Hypophosphatemic Rickets	3%
682	Adenomatous Polyposis Coli	3%
683	Urogenital Abnormalities	2.9%
684	Malaria, Cerebral	2.9%
685	Neonatal Abstinence Syndrome	2.9%
686	Maxillofacial Abnormalities	2.9%
687	Neurocysticercosis	2.9%
688	Thoracic Outlet Syndrome	2.9%
689	Dextrocardia	2.9%
690	Esotropia	2.8%
691	Exotropia	2.8%
692	Hypotension, Orthostatic	2.8%
693	Sleep Apnea Syndromes	2.8%
694	Polymyositis	2.8%
695	Post-Exercise Hypotension	2.8%
696	Fetal Growth Retardation	2.8%
697	Disorders of Excessive Somnolence	2.8%
698	Sleep Initiation and Maintenance Disorders	2.8%
699	Night Terrors	2.8%
700	Somnambulism	2.8%
701	Trigeminal Nerve Disorder	2.8%
702	Transient Insomnia	2.8%
703	Sleep Paralysis	2.8%
704	Chronic Insomnia	2.8%
705	REM Sleep Behavior Disorder	2.8%
706	Hypersomnia	2.8%
707	Fetal Hypoxia	2.8%
708	Fetal Alcohol Spectrum Disorders	2.8%
709	Dysgeusia	2.8%
710	Formication	2.8%
711	Hyperalgesia	2.8%
712	Hyperesthesia	2.8%
713	Hypesthesia	2.8%
714	Language Disorders	2.8%
715	Numbness	2.8%
716	Paresthesia	2.8%
717	Paraparesis, Spastic	2.8%
718	Trismus	2.8%
719	Epilepsia Partialis Continua	2.8%
720	Hypogeusia	2.8%
721	Meningeal Carcinomatosis	2.8%
722	Brown-Sequard Syndrome	2.8%
723	Lockjaw	2.8%
724	Allodynia	2.8%
725	Lead Poisoning, Nervous System, Childhood	2.8%
726	Lead Poisoning, Nervous System, Adult	2.8%
727	Ageusia	2.8%
728	Syphilis, Congenital	2.8%
729	Hoarseness	2.7%
730	Prolactinoma	2.7%
731	Growth Hormone-Secreting Pituitary Adenoma	2.7%
732	Alcohol Withdrawal Delirium	2.7%
733	Arthritis, Gouty	2.7%
734	Alexia	2.7%
735	Dyslexia	2.7%
736	Waterhouse-Friderichsen Syndrome	2.7%
737	Glycosuria, Renal	2.6%
738	Epilepsy	2.6%
739	Prune Belly Syndrome	2.6%
740	Twins, Conjoined	2.6%
741	Aura	2.6%
742	Waardenburg Syndrome	2.6%
743	Kearns-Sayre syndrome	2.6%
744	Cavernous Sinus Thrombosis	2.6%
745	Sagittal Sinus Thrombosis	2.6%
746	Eye Injuries	2.5%
747	Congenital Hyperinsulinism	2.5%
748	Chorioamnionitis	2.5%
749	Orbital Myositis	2.5%
750	Diplopia	2.5%
751	Muscle Rigidity	2.5%
752	Muscle Spasticity	2.5%
753	Scotoma	2.5%
754	Photophobia	2.5%
755	Cogwheel Rigidity	2.5%
756	Hemifacial Spasm	2.5%
757	Amaurosis	2.5%
758	Blindness	2.5%
759	Nuchal Rigidity	2.5%
760	Pyomyositis	2.4%
761	Agnosia	2.4%
762	Apraxias	2.4%
763	Hallucinations	2.4%
764	Hemianopsia	2.4%
765	Hyperacusis	2.4%
766	Tinnitus	2.4%
767	Visual Agnosia	2.4%
768	Anosognosia	2.4%
769	Wernicke-Korsakoff Syndrome	2.4%
770	Phonophobia	2.4%
771	Hearing Loss	2.4%
772	Sarcopenia	2.4%
773	Polyradiculopathy	2.4%
774	Neurofibrosarcoma	2.4%
775	Scimitar Syndrome	2.3%
776	Denys-Drash Syndrome	2.3%
777	Acrocephalosyndactylia	2.3%
778	Nelson Syndrome	2.3%
779	Anophthalmos	2.2%
780	Anus, Imperforate	2.2%
781	Microphthalmos	2.2%
782	Paralysis, Obstetric	2.2%
783	Retinopathy of Prematurity	2.2%
784	Limb Deformities, Congenital	2.2%
785	Craniofacial Abnormalities	2.2%
786	Anorectal Malformations	2.2%
787	Abnormalities, Radiation-Induced	2.2%
788	Bloom Syndrome	2.2%
789	Bronchopulmonary Dysplasia	2.2%
790	Craniosynostosis	2.2%
791	Syndactyly	2.2%
792	Brachycephaly	2.2%
793	Amnesia	2.1%
794	Delirium	2.1%
795	Dissociative Amnesia	2.1%
796	Color blindness	2.1%
797	Global Amnesia	2.1%
798	Meningioma	2.1%
799	Sleep Apnea, Obstructive	2%
800	Sleep Apnea, Central	2%
801	Narcolepsy	2%
802	Trigeminal Neuralgia	2%
803	Kleine-Levin Syndrome	2%
804	Agraphia	2%
805	Anomia	2%
806	Cluttering	2%
807	Language Development Disorders	2%
808	Speech Disorders	2%
809	Syncope	2%
810	Stupor	2%
811	Dysgraphia	2%
812	Presyncope	2%
813	Dyslalia	2%
814	Noonan Syndrome	2%
815	Ophthalmia Neonatorum	1.9%
816	Cleft Palate	1.9%
817	Blepharophimosis	1.9%
818	Laryngostenosis	1.9%
819	Mouth Abnormalities	1.9%
820	Respiratory Distress Syndrome, Newborn	1.9%
821	Esophageal Atresia	1.9%
822	Intestinal Atresia	1.9%
823	Horseshoe Kidney	1.9%
824	Pectus excavatum	1.9%
825	Phantom pain	1.9%
826	Phantom Limb Pain	1.9%
827	Klippel-Feil Syndrome	1.9%
828	Gastroschisis	1.9%
829	Synostosis	1.9%
830	Acrodermatitis	1.9%
831	Lymphangiectasis, Intestinal	1.9%
832	Gianotti-Crosti Syndrome	1.9%
833	Jaw Abnormalities	1.8%
834	Poland Syndrome	1.8%
835	Eye Burns	1.7%
836	Amaurosis Fugax	1.7%
837	Blindness, Cortical	1.7%
838	Dyscalculia	1.7%
839	Deafness	1.7%
840	Hearing Loss, Sudden	1.7%
841	Gerstmann Syndrome	1.7%
842	Hearing Loss, Bilateral	1.7%
843	Hearing Loss, High-Frequency	1.7%
844	Hearing Loss, Mixed Conductive-Sensorineural	1.7%
845	Prosopagnosia	1.7%
846	Apraxia, Ideomotor	1.7%
847	Charles Bonnet Syndrome	1.7%
848	Hearing Loss, Unilateral	1.7%
849	Complete Hearing Loss	1.7%
850	Alien Hand Syndrome	1.7%
851	Deaf Mutism	1.7%
852	Arthrogryposis	1.7%
853	Choanal Atresia	1.7%
854	Tracheobronchomegaly	1.7%
855	Laryngocele	1.7%
856	Choledochal Cyst	1.7%
857	Hermaphroditism	1.7%
858	Disorders of Sex Development	1.7%
859	Cryptorchidism	1.7%
860	Hypospadias	1.7%
861	Amelia	1.6%
862	Arachnodactyly	1.6%
863	Ectopia Cordis	1.6%
864	Ectromelia	1.6%
865	Hemimelia	1.6%
866	Phocomelia	1.6%
867	Sirenomelia	1.6%
868	Polydactyly	1.6%
869	Brachydactyly	1.6%
870	Plagiocephaly	1.6%
871	Lower Extremity Deformities, Congenital	1.6%
872	Upper Extremity Deformities, Congenital	1.6%
873	Single umbilical artery	1.6%
874	Nesidioblastosis	1.6%
875	Cataplexy	1.6%
876	Aphasia	1.6%
877	Articulation Disorders	1.6%
878	Echolalia	1.6%
879	Stuttering	1.6%
880	Dysphasia	1.6%
881	Dermatomyositis	1.5%
882	Corneal Scar	1.5%
883	Micrognathism	1.5%
884	Pierre Robin Syndrome	1.5%
885	Retrograde amnesia	1.5%
886	Amnesia, Anterograde	1.5%
887	Laryngomalacia	1.5%
888	Pectus carinatum	1.5%
889	Bladder Exstrophy	1.5%
890	Epispadias	1.5%
891	Multicystic Dysplastic Kidney	1.5%
892	Dysarthria	1.4%
893	Retrognathia	1.4%
894	Aortic coarctation	1.4%
895	Cor Triatriatum	1.4%
896	Coronary Vessel Anomalies	1.4%
897	Dental Enamel Hypoplasia	1.4%
898	Patent ductus arteriosus	1.4%
899	Ebstein Anomaly	1.4%
900	Heart Septal Defects	1.4%
901	Hyaline Membrane Disease	1.4%
902	Hypodontia	1.4%
903	Macrostomia	1.4%
904	Microstomia	1.4%
905	Tetralogy of Fallot	1.4%
906	Transposition of Great Vessels	1.4%
907	Hypoplastic Left Heart Syndrome	1.4%
908	May-Thurner Syndrome	1.4%
909	Mutism	1.4%
910	Selective Mutism	1.4%
911	Craniofacial Dysostosis	1.4%
912	Wolff-Parkinson-White Syndrome	1.4%
913	Hyperandrogenism	1.3%
914	Prognathism	1.3%
915	Long QT Syndrome	1.2%
916	Platybasia	1.2%
917	Tricuspid Atresia	1.2%
918	Arrhythmogenic Right Ventricular Dysplasia	1.2%
919	Gonadal Dysgenesis	1.2%
920	Bronchomalacia	1.2%
921	Adrenogenital Syndrome	1.2%
922	Tracheomalacia	1.2%
923	Ovotesticular Disorders of Sex Development	1.2%
924	Corneal Perforation	1.2%
925	Alexia, Pure	1.2%
926	Aortopulmonary Septal Defect	1.2%
927	Double Outlet Right Ventricle	1.2%
928	Endocardial Cushion Defects	1.2%
929	Myocardial bridging	1.2%
930	Aorticopulmonary Septal Defect	1.2%
931	Truncus Arteriosus, Persistent	1%
932	Goldenhar Syndrome	1%
933	Mandibulofacial Dysostosis	1%
934	Romano-Ward Syndrome	1%
935	Talipes	0.9%
936	Congenital clubfoot	0.9%
937	Vertical Talus	0.9%
938	Arteriovenous fistula	0.8%

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