MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Smith-Magenis syndrome

(UMLS:C0795864)

Definition:: Complex neurobehavioral disorder characterized by distinctive facial features (FACIES), developmental delay and INTELLECTUAL DISABILITY. Behavioral phenotypes include sleep disturbance, maladaptive, self-injurious and attention-seeking behaviors. The sleep disturbance is linked to an abnormal circadian secretion pattern of MELATONIN. The syndrome is associated with de novo deletion or mutation and HAPLOINSUFFICIENCY of the retinoic acid-induced 1 protein on chromosome 17p11.2.
UMLS ID:: C0795864
MeSH ID:: D058496

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.281.900

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.077.879|C16.131.260.887|C16.320.180.887

Synonym(s)

Smith-Magenis syndrome

17p deletion syndrome

17p- syndrome

Chromosome 17p11.2 Deletion Syndrome

SMITH-MAGENIS SYNDROME

Smith Magenis syndrome

Smith-Magenis Syndrome

Smith-Magenis syndrome (SMS)

chromosome 17p deletion syndrome

10.

chromosome 17p monosomy

11.

del(17p) syndrome

12.

deletion 17p syndrome

13.

magenis smith syndrome

14.

magenis syndrome smith

15.

monosomy 17p

16.

partial monosomy 17p

17.

smith magenis syndrome

18.

smith-magenis syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Risperidone		17914318	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Beckwith-Wiedemann Syndrome	59.6%
2	Wolf-Hirschhorn Syndrome	59.6%
3	Cri-du-Chat Syndrome	54%
4	Down Syndrome	54%
5	Trisomy 21	54%
6	Holoprosencephaly	52.1%
7	Prader-Willi Syndrome	47.8%
8	Rubinstein-Taybi Syndrome	45.3%
9	Aicardi's syndrome	36.9%
10	CHARGE Syndrome	35.9%
11	Williams Syndrome	35.3%
12	Fragile X Syndrome	34.6%
13	Ectodermal Dysplasia	34.3%
14	Aplasia Cutis Congenita	34.3%
15	Nail-Patella Syndrome	31.6%
16	Alstrom Syndrome	30.3%
17	Cockayne Syndrome	30.1%
18	Prune Belly Syndrome	29.7%
19	Waardenburg Syndrome	29.7%
20	Marfan Syndrome	29.2%
21	Kartagener Syndrome	29.1%
22	Mobius Syndrome	28.8%
23	Abnormalities, Drug-Induced	28.8%
24	Situs Inversus	28.8%
25	Polycystic Kidney Diseases	26.6%
26	Anencephaly	26.3%
27	Bloom Syndrome	24.7%
28	Eye Abnormalities	24.7%
29	Cardiovascular Abnormalities	24.7%
30	Smith-Lemli-Opitz Syndrome	24.4%
31	Skin Abnormalities	24.1%
32	Lymphatic Abnormalities	24.1%
33	Congenital Microtia	24.1%
34	Dural Arteriovenous Fistula	24.1%
35	Congenital diaphragmatic hernia	23.7%
36	Primary Ciliary Dyskinesia	23.3%
37	Ichthyosis, X-Linked	22.4%
38	Urogenital Abnormalities	21.2%
39	Classical Lissencephalies and Subcortical Band Heterotopias	21%
40	Cystic Fibrosis	20.9%
41	Maxillofacial Abnormalities	20.7%
42	Dextrocardia	20.5%
43	Hydranencephaly	20.5%
44	Neural Tube Defects	20.5%
45	Tethered Cord Syndrome	20.5%
46	Iniencephaly	20.5%
47	Craniorachischisis	20.5%
48	Exencephaly	20.5%
49	Septo-Optic Dysplasia	20.5%
50	Cortical Dysplasia	20.5%
51	Myasthenic Syndromes, Congenital	20.5%
52	Malformations of Cortical Development	20.5%
53	POEMS Syndrome	20.4%
54	Turner Syndrome	20.3%
55	Klinefelter Syndrome	20.1%
56	Tuberous Sclerosis	20%
57	Polycystic Kidney, Autosomal Dominant	19.7%
58	Xeroderma	19.5%
59	Dandy-Walker Syndrome	19.3%
60	Twins, Conjoined	18.9%
61	Charcot-Marie-Tooth Disease	18.9%
62	Refsum Disease	18.7%
63	Zellweger Syndrome	18.5%
64	Muscular Dystrophy, Duchenne	18.5%
65	Retinal Dysplasia	18.3%
66	Aniridia	18.2%
67	Microcephaly	18%
68	Macrocephaly	18%
69	Epidermolysis Bullosa	17.9%
70	Central Nervous System Cysts	17.7%
71	Fetal Diseases	17.6%
72	Neoplastic Syndromes, Hereditary	17.6%
73	Multiple Epiphyseal Dysplasia	17%
74	Osteochondrodysplasias	17%
75	Pelger-Huet Anomaly	17%
76	Werner Syndrome	17%
77	Smith-Magenis syndrome	16.9%
78	Muscular Dystrophy	16.9%
79	Myotonic Dystrophy	16.7%
80	Scimitar Syndrome	16.7%
81	Albinism	16.7%
82	Anemia, Sickle Cell	16.7%
83	Thalassemia	16.7%
84	Sjogren-Larsson Syndrome	16.6%
85	Porencephaly	16.5%
86	Rett Syndrome	16.3%
87	Basal Cell Nevus Syndrome	16.3%
88	Acrocephalosyndactylia	16.2%
89	Mucopolysaccharidosis II	16.1%
90	Menkes Kinky Hair Syndrome	16.1%
91	Anophthalmos	15.9%
92	Anus, Imperforate	15.9%
93	Microphthalmos	15.9%
94	Limb Deformities, Congenital	15.9%
95	Craniofacial Abnormalities	15.9%
96	Anorectal Malformations	15.9%
97	Kallmann Syndrome	15.8%
98	Hepatolenticular Degeneration	15.8%
99	Abnormalities, Radiation-Induced	15.7%
100	Adrenoleukodystrophy	15.6%
101	Craniosynostosis	15.5%
102	Syndactyly	15.5%
103	Brachycephaly	15.5%
104	Meningomyelocele	15.1%
105	Spina Bifida	15.1%
106	Dwarfism	15%
107	Dystonia Musculorum Deformans	15%
108	Pseudoxanthoma Elasticum	14.7%
109	Canavan Disease	14.6%
110	Alexander Disease	14.6%
111	Osteogenesis Imperfecta	14.5%
112	Ataxia Telangiectasia	14.3%
113	Lafora Disease	14.2%
114	Unverricht-Lundborg Syndrome	14.2%
115	Neuronal Ceroid-Lipofuscinoses	14.2%
116	Noonan Syndrome	14.1%
117	Genetic Diseases, Inborn	14.1%
118	Amyloid Neuropathies, Familial	13.8%
119	Cleft Palate	13.7%
120	Meconium Aspiration Syndrome	13.7%
121	Blepharophimosis	13.7%
122	Laryngostenosis	13.7%
123	Mouth Abnormalities	13.7%
124	Esophageal Atresia	13.6%
125	Intestinal Atresia	13.6%
126	Horseshoe Kidney	13.6%
127	Pectus excavatum	13.6%
128	Hyperkeratosis, Epidermolytic	13.6%
129	Klippel-Feil Syndrome	13.5%
130	Gastroschisis	13.5%
131	Synostosis	13.5%
132	Familial Mediterranean Fever	13.5%
133	Xeroderma Pigmentosum	13.5%
134	Acrodermatitis	13.5%
135	Lymphangiectasis, Intestinal	13.5%
136	Gianotti-Crosti Syndrome	13.5%
137	Wiskott-Aldrich Syndrome	13.3%
138	Antley-Bixler Syndrome Phenotype	13.2%
139	Sleep Disorders, Circadian Rhythm	13%
140	Myotonia Congenita	13%
141	Jaw Abnormalities	12.9%
142	Meningocele	12.9%
143	Encephalocele	12.9%
144	Autoimmune Lymphoproliferative Syndrome	12.8%
145	Poland Syndrome	12.7%
146	Fabry Disease	12.6%
147	Angioedemas, Hereditary	12.6%
148	Dermal Sinus	12.5%
149	Spina Bifida Cystica	12.5%
150	Spina Bifida Occulta	12.5%
151	Lissencephaly	12.5%
152	Polymicrogyria	12.5%
153	Pachygyria	12.5%
154	Schizencephaly	12.5%
155	Periventricular Nodular Heterotopia	12.5%
156	Sickle Cell Trait	12.4%
157	Abdominal Cramps	12.3%
158	Amniotic Band Syndrome	12.3%
159	Asphyxia Neonatorum	12.3%
160	Infant, Premature, Diseases	12.3%
161	Infantile Colic	12.3%
162	Huntington Disease	12.2%
163	Arthrogryposis	12.1%
164	Choanal Atresia	12.1%
165	Tracheobronchomegaly	12.1%
166	Laryngocele	12.1%
167	Choledochal Cyst	12%
168	Hermaphroditism	12%
169	Disorders of Sex Development	12%
170	Cryptorchidism	11.9%
171	Hypospadias	11.9%
172	Optic Atrophy, Hereditary, Leber	11.8%
173	Amelia	11.7%
174	Arachnodactyly	11.7%
175	Ectopia Cordis	11.7%
176	Ectromelia	11.7%
177	Hemimelia	11.7%
178	Phocomelia	11.7%
179	Sirenomelia	11.7%
180	Polydactyly	11.7%
181	Brachydactyly	11.7%
182	Plagiocephaly	11.7%
183	Lower Extremity Deformities, Congenital	11.7%
184	Upper Extremity Deformities, Congenital	11.7%
185	Single umbilical artery	11.7%
186	Welander Distal Myopathy	11.6%
187	Galactosemias	11.3%
188	Urea Cycle Disorders, Inborn	11.3%
189	Tyrosinemias	11.3%
190	Glycogen storage disease type II	11.3%
191	Amino Acid Metabolism, Inborn Errors	11.2%
192	Carbohydrate Metabolism, Inborn Errors	11.2%
193	Metal Metabolism, Inborn Errors	11.2%
194	Progeria	11.2%
195	Lysosomal Storage Diseases	11.2%
196	Cytochrome-c Oxidase Deficiency	11.2%
197	Peroxisomal Disorders	11.2%
198	Duane Retraction Syndrome	11.1%
199	Congenital nystagmus	11.1%
200	Micrognathism	10.9%
201	Pierre Robin Syndrome	10.9%
202	Friedreich Ataxia	10.8%
203	Jet Lag Syndrome	10.8%
204	Toxoplasmosis, Congenital	10.8%
205	Laryngomalacia	10.7%
206	Pectus carinatum	10.6%
207	Multiple System Atrophy	10.5%
208	Bladder Exstrophy	10.5%
209	Epispadias	10.5%
210	Brain Diseases, Metabolic, Inborn	10.5%
211	Multicystic Dysplastic Kidney	10.4%
212	Anemia, Neonatal	10.2%
213	Persistent Fetal Circulation Syndrome	10.2%
214	Umbilical hernia	10.1%
215	Aortic coarctation	10%
216	Cor Triatriatum	10%
217	Coronary Vessel Anomalies	10%
218	Dental Enamel Hypoplasia	10%
219	Patent ductus arteriosus	10%
220	Ebstein Anomaly	10%
221	Heart Septal Defects	10%
222	Hypodontia	10%
223	Macrostomia	10%
224	Microstomia	10%
225	Tetralogy of Fallot	10%
226	Transposition of Great Vessels	10%
227	Hypoplastic Left Heart Syndrome	10%
228	May-Thurner Syndrome	10%
229	Acute Chest Syndrome	10%
230	Craniofacial Dysostosis	10%
231	Retrognathia	10%
232	Wolff-Parkinson-White Syndrome	10%
233	Cutis Laxa	9.7%
234	Retinitis Pigmentosa	9.7%
235	Pigmentary retinopathy	9.7%
236	Porokeratosis	9.6%
237	Keratoderma, Palmoplantar	9.6%
238	Homocystinuria	9.6%
239	Chronic granulomatous disease	9.6%
240	Leigh Disease	9.5%
241	Hyperandrogenism	9.5%
242	Stiff-Person Syndrome	9.4%
243	Gaucher Disease	9.4%
244	Motor Neuron Disease	9.2%
245	Ophthalmoplegic Migraine	9.2%
246	Leukomalacia, Periventricular	9.2%
247	Meningoencephalitis	9.2%
248	Prognathism	9.1%
249	Mucopolysaccharidosis III	9.1%
250	Hyperphosphaturia	8.9%
251	Polyradiculoneuropathy	8.9%
252	Polyradiculoneuritis	8.9%
253	Amyotrophic Lateral Sclerosis	8.9%
254	Neonatal Abstinence Syndrome	8.9%
255	Familial Periodic Paralysis	8.8%
256	Long QT Syndrome	8.8%
257	Platybasia	8.8%
258	Tricuspid Atresia	8.8%
259	Arrhythmogenic Right Ventricular Dysplasia	8.8%
260	Gonadal Dysgenesis	8.7%
261	Bronchomalacia	8.7%
262	Adrenogenital Syndrome	8.7%
263	Tracheomalacia	8.7%
264	Ovotesticular Disorders of Sex Development	8.7%
265	Fetal Growth Retardation	8.7%
266	Restless Legs Syndrome	8.7%
267	Fetal Hypoxia	8.7%
268	Fetal Alcohol Spectrum Disorders	8.7%
269	Carbamoyl-Phosphate Synthase I Deficiency Disease	8.7%
270	Spinal Muscular Atrophy	8.7%
271	Progressive Muscular Atrophy	8.7%
272	Tay-Sachs Disease	8.6%
273	Syphilis, Congenital	8.6%
274	Striatonigral Degeneration	8.5%
275	Porphyrias, Hepatic	8.5%
276	Cranial nerve diseases	8.5%
277	Demyelinating Diseases	8.5%
278	Demyelination	8.5%
279	Neuromuscular Diseases	8.5%
280	Leukoencephalitis, Acute Hemorrhagic	8.4%
281	Parkinson Disease	8.4%
282	Peutz-Jeghers Syndrome	8.4%
283	Thrombasthenia	8.4%
284	Antithrombin III Deficiency	8.4%
285	Protein C Deficiency	8.4%
286	Lewy Body Disease	8.3%
287	Afibrinogenemia	8.3%
288	Alkaptonuria	8.3%
289	Factor VII Deficiency	8.3%
290	Factor X Deficiency	8.3%
291	Factor XII Deficiency	8.3%
292	Glycogen Storage Disease	8.3%
293	Hemophilia A	8.3%
294	Hypophosphatasia	8.3%
295	Propionic acidemia	8.3%
296	Activated Protein C Resistance	8.3%
297	Dihydropyrimidine Dehydrogenase Deficiency	8.3%
298	Factor II deficiency	8.3%
299	Factor VIII Deficiency	8.3%
300	Cystinosis	8.3%
301	Factor V deficiency	8.3%
302	Factor XI Deficiency	8.3%
303	Hypoprothrombinemias	8.3%
304	Miller Fisher Syndrome	8.3%
305	Guillain-Barre Syndrome	8.3%
306	Fanconi Anemia	8.3%
307	Subacute Combined Degeneration	8.3%
308	Aortopulmonary Septal Defect	8.3%
309	Double Outlet Right Ventricle	8.3%
310	Endocardial Cushion Defects	8.3%
311	Myocardial bridging	8.3%
312	Aorticopulmonary Septal Defect	8.3%
313	Anemia, Diamond-Blackfan	8.3%
314	Niemann-Pick Disease, Type C	8.2%
315	Progressive supranuclear palsy	8.1%
316	Ocular Motility Disorders	8.1%
317	Cyclophoria	8.1%
318	Encephalomyelitis	8%
319	Prion Diseases	8%
320	Autonomic Dysreflexia	8%
321	Complex Regional Pain Syndromes	8%
322	Myelitis, Transverse	7.7%
323	Multiple Endocrine Neoplasia	7.6%
324	Congenital Hyperinsulinism	7.6%
325	Causalgia	7.6%
326	Chorioamnionitis	7.6%
327	Shy-Drager Syndrome	7.6%
328	Pneumocephalus	7.5%
329	Poliomyelitis	7.5%
330	Congenital Hypothyroidism	7.5%
331	Dermatitis, Atopic	7.5%
332	Neuromyelitis Optica	7.4%
333	Hydrops Fetalis	7.4%
334	Truncus Arteriosus, Persistent	7.4%
335	Goldenhar Syndrome	7.4%
336	Marchiafava-Bignami Disease	7.3%
337	Hypokalemic periodic paralysis	7.2%
338	Mandibulofacial Dysostosis	7.2%
339	Trauma, Nervous System	7.2%
340	Romano-Ward Syndrome	7.2%
341	MELAS Syndrome	7.1%
342	Hypolipoproteinemias	7.1%
343	Papillon-Lefevre Disease	7.1%
344	Hyperlipidemia, Familial Combined	7.1%
345	Hyperlipoproteinemia Type III	7.1%
346	Epidural Abscess	7.1%
347	Olfactory Nerve Injuries	7.1%
348	Nervous System Neoplasms	7.1%
349	Neurologic Manifestations	7.1%
350	Neurotoxicity Syndromes	7.1%
351	Deformity	7%
352	Opsoclonus-Myoclonus Syndrome	7%
353	MPTP Poisoning	7%
354	Spinal Cord Injuries	7%
355	Glycogen Storage Disease Type I	6.9%
356	Glycogen Storage Disease Type V	6.9%
357	Peripheral Nerve Injuries	6.9%
358	Encephalomyelitis, Acute Disseminated	6.9%
359	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	6.9%
360	Paralysis, Obstetric	6.8%
361	Retinopathy of Prematurity	6.8%
362	Myasthenia Gravis	6.8%
363	Asterixis	6.8%
364	Ballismus	6.8%
365	Leukoencephalopathy, Progressive Multifocal	6.8%
366	Myelitis	6.7%
367	Progressive bulbar palsy	6.7%
368	Bulbar palsy	6.7%
369	Lambert-Eaton Myasthenic Syndrome	6.7%
370	Bronchopulmonary Dysplasia	6.7%
371	Behcet Syndrome	6.7%
372	Denys-Drash Syndrome	6.6%
373	Talipes	6.5%
374	Lupus Vasculitis, Central Nervous System	6.4%
375	Dyskinesia, Drug-Induced	6.4%
376	Facial Nerve Injuries	6.3%
377	Neuroleptic Malignant Syndrome	6.3%
378	Myelinolysis, Central Pontine	6.3%
379	Lactose Intolerance	6.2%
380	Variegate Porphyria	6.2%
381	Acute intermittent porphyria	6.2%
382	Porphyria Cutanea Tarda	6.2%
383	Hyperhomocysteinemia	6.2%
384	Epilepsy, Post-Traumatic	6.2%
385	Renal Aminoacidurias	6.2%
386	Fanconi Syndrome	6.2%
387	Pseudohypoaldosteronism	6.2%
388	Liddle Syndrome	6.2%
389	Hyperlipoproteinemia Type IV	6.2%
390	Hyperlipoproteinemia Type V	6.2%
391	Reflex Sympathetic Dystrophy	6.1%
392	Subdural Effusion	6.1%
393	Parkinsonian Disorders	6.1%
394	Nocturnal Myoclonus Syndrome	6.1%
395	Chronic Fatigue Syndrome	6.1%
396	Sleep Wake Disorders	6.1%
397	Congenital clubfoot	6.1%
398	Vertical Talus	6.1%
399	Ophthalmia Neonatorum	6%
400	Botulism	5.9%
401	Limbic Encephalitis	5.9%
402	Respiratory Distress Syndrome, Newborn	5.9%
403	Hypoalphalipoproteinemias	5.9%
404	Arteriovenous fistula	5.8%
405	Brain Injuries	5.8%
406	Cerebellar Neoplasms	5.7%
407	Brain Neoplasms	5.7%
408	Multiple Sclerosis	5.7%
409	Spinal Cord Neoplasms	5.7%
410	Dementia, Vascular	5.7%
411	Brain Hemorrhage, Traumatic	5.7%
412	Kernicterus	5.7%
413	Myasthenia Gravis, Autoimmune, Experimental	5.6%
414	Gout	5.6%
415	Meige Syndrome	5.6%
416	Multiple Endocrine Neoplasia Type 1	5.6%
417	Pseudohypoparathyroidism	5.6%
418	Brachial Plexus Neuritis	5.6%
419	Neuralgic Amyotrophy	5.6%
420	Cerebral Ventriculitis	5.6%
421	Nephroblastoma	5.5%
422	Renal tubular acidosis	5.5%
423	Brain Diseases	5.5%
424	Dysautonomia	5.5%
425	Meningitis	5.5%
426	Movement Disorders	5.5%
427	Pachymeningitis	5.5%
428	Spinal Cord Diseases	5.5%
429	Vagus Nerve Disorder	5.5%
430	Glossopharyngeal Neuralgia	5.5%
431	Abducens Nerve Diseases	5.5%
432	Heavy Metal Poisoning, Nervous System	5.5%
433	Neuromuscular Junction Diseases	5.5%
434	Tauopathies	5.5%
435	Trochlear Nerve Diseases	5.5%
436	Peripheral Nervous System Diseases	5.5%
437	Horner Syndrome	5.5%
438	Scrapie	5.3%
439	Central Cord Syndrome	5.3%
440	Akathisia, Drug-Induced	5.3%
441	Presenile dementia	5.3%
442	Senile dementia	5.3%
443	Tarsal Tunnel Syndrome	5.3%
444	Meningitis, Bacterial	5.3%
445	Meningitis, Fungal	5.3%
446	Cauda Equina Syndrome	5.3%
447	Posterior Leukoencephalopathy Syndrome	5.3%
448	Posterior reversible encephalopathy syndrome	5.3%
449	Chorea	5.2%
450	Acrodynia	5.2%
451	Cystinuria	5.1%
452	Tuberculosis, Meningeal	5.1%
453	Brain Abscess	5.1%
454	Ophthalmoplegia	5.1%
455	External Ophthalmoplegia	5.1%
456	Adenomatous Polyposis Coli	5%
457	Familial Hypophosphatemic Rickets	5%
458	Nesidioblastosis	5%
459	Myoclonic Epilepsy	5%
460	Epilepsy, Temporal Lobe	5%
461	Epilepsy, Rolandic	5%
462	Benign Rolandic Epilepsy	5%
463	Carotid Artery Injuries	5%
464	Brain Death	4.9%
465	Coma, Post-Head Injury	4.9%
466	Vasculitis, Central Nervous System	4.9%
467	Pituitary Adenoma	4.8%
468	Pituitary Neoplasms	4.8%
469	Creutzfeldt-Jakob disease	4.8%
470	Basal Ganglia Cerebrovascular Disease	4.8%
471	Brain Injuries, Diffuse	4.7%
472	Traumatic Brain Injury	4.7%
473	Cerebellar Ataxia	4.7%
474	Supratentorial Neoplasms	4.7%
475	Torticollis	4.7%
476	Multiple Sclerosis, Chronic Progressive	4.7%
477	Multiple Sclerosis, Relapsing-Remitting	4.7%
478	Central Nervous System Infection	4.7%
479	Myopathy	4.7%
480	Optic Neuropathy	4.7%
481	Juvenile Myoclonic Epilepsy	4.7%
482	Myoclonic Epilepsies, Progressive	4.7%
483	Alice in Wonderland Syndrome	4.7%
484	Amblyopia	4.6%
485	Brain Concussion	4.6%
486	Facial Nerve Diseases	4.6%
487	Craniocerebral Trauma	4.6%
488	Parasomnia	4.6%
489	Dyssomnias	4.6%
490	Paraneoplastic Cerebellar Degeneration	4.6%
491	Arthritis, Gouty	4.6%
492	Cerebrospinal Fluid Otorrhea	4.6%
493	Cerebrospinal Fluid Rhinorrhea	4.6%
494	Neuritis, Autoimmune, Experimental	4.6%
495	Gait Ataxia	4.6%
496	Vestibulocochlear Nerve Diseases	4.5%
497	Decerebrate State	4.5%
498	Hemiparesis	4.5%
499	Meningism	4.5%
500	Paresis	4.5%
501	Seizures	4.5%
502	Sensation Disorders	4.5%
503	Central Nervous System Neoplasms	4.5%
504	Complex partial seizures	4.5%
505	Monoparesis	4.5%
506	Neurogenic Inflammation	4.5%
507	Gait Disorders, Neurologic	4.5%
508	Neuromuscular Manifestations	4.5%
509	Vocal Cord Paralysis	4.5%
510	Optic Nerve Glioma	4.5%
511	Sweating, Gustatory	4.5%
512	Auriculotemporal Syndrome	4.5%
513	Carpal Tunnel Syndrome	4.5%
514	Vascular Headaches	4.5%
515	neurofibroma	4.5%
516	Hypoxia-Ischemia, Brain	4.5%
517	Sciatica	4.5%
518	Tardive Dyskinesia	4.5%
519	Persistent Vegetative State	4.5%
520	Glycosuria, Renal	4.5%
521	Toxoplasmosis, Cerebral	4.3%
522	Basal Ganglia Hemorrhage	4.3%
523	Hyaline Membrane Disease	4.3%
524	Cubital Tunnel Syndrome	4.2%
525	Diffuse Axonal Injury	4.2%
526	Brain Stem Neoplasms	4.2%
527	Putaminal Hemorrhage	4.1%
528	Akinetic Mutism	4.1%
529	Anoxic Encephalopathy	4.1%
530	Arachnoiditis	4.1%
531	Basal Ganglia Diseases	4.1%
532	Brain Damage, Chronic	4.1%
533	Cerebellar Diseases	4.1%
534	Encephalitis	4.1%
535	Encephalomalacia	4.1%
536	Epilepsy	4.1%
537	Hydrocephalus	4.1%
538	Congenital Hydrocephalus	4.1%
539	Hypothalamic Diseases	4.1%
540	Aseptic Meningitis	4.1%
541	Neuritis	4.1%
542	Polyneuritis	4.1%
543	Radiculitis	4.1%
544	Syringomyelia	4.1%
545	Thalamic Diseases	4.1%
546	Intracranial Hypertension	4.1%
547	Polyneuropathy	4.1%
548	Mononeuritis	4.1%
549	Aura	4.1%
550	Leukoencephalopathy	4.1%
551	Essential Tremor	4.1%
552	Neuroaxonal Dystrophies	4.1%
553	Familial Tremor	4.1%
554	Headache Disorders	4.1%
555	Mononeuropathies	4.1%
556	Intracranial Hypotension	4.1%
557	Brachial Plexus Neuropathies	4.1%
558	Radiculopathy	4.1%
559	Mononeuropathy Multiplex	4.1%
560	Nerve Root Compression	4.1%
561	Brain Edema	4.1%
562	Brain Hypoxia	4.1%
563	Aqueductal Stenosis	4.1%
564	Pneumorrhachis	4.1%
565	Writer's Cramp	4.1%
566	Infarction, Middle Cerebral Artery	4.1%
567	Infarction, Anterior Cerebral Artery	4.1%
568	Infarction, Posterior Cerebral Artery	4.1%
569	Akathisia	4.1%
570	Restlessness	4.1%
571	Psychomotor Agitation	4.1%
572	Subacute Sclerosing Panencephalitis	4%
573	Pupil Disorders	4%
574	Subarachnoid Hemorrhage, Traumatic	4%
575	Neurobehavioral Manifestations	4%
576	Carotid Artery, Internal, Dissection	4%
577	Choroid Plexus Papilloma	4%
578	Alcohol Withdrawal Seizures	4%
579	Meningitis, Cryptococcal	3.9%
580	Paraneoplastic Encephalomyelitis	3.9%
581	Meningitis, Listeria	3.9%
582	Meningitis, Haemophilus	3.9%
583	Meningitis, Pneumococcal	3.9%
584	Frontotemporal dementia	3.9%
585	Uveomeningoencephalitic Syndrome	3.9%
586	Vertebral Artery Dissection	3.9%
587	Sturge-Weber Syndrome	3.9%
588	Vertigo	3.9%
589	Alcohol-Induced Disorders, Nervous System	3.9%
590	Amnesia, Transient Global	3.9%
591	Gait Apraxia	3.8%
592	Pituitary Apoplexy	3.7%
593	Brain Contusion	3.7%
594	Brain Infarction	3.7%
595	Mitochondrial Encephalomyopathies	3.7%
596	Cerebral Infarction	3.5%
597	Brain Stem Infarctions	3.5%
598	West Nile Fever	3.5%
599	Voice Disorders	3.4%
600	Voice Disturbance	3.4%
601	Brain Diseases, Metabolic	3.4%
602	Cerebrovascular Disorders	3.4%
603	Myositis	3.4%
604	Optic Atrophy	3.4%
605	Optic Neuritis	3.4%
606	Papilledema	3.4%
607	Strabismus	3.4%
608	Tolosa-Hunt Syndrome	3.4%
609	Cerebrovascular Insufficiency	3.4%
610	Isaacs syndrome	3.4%
611	Arsenic Poisoning	3.4%
612	Dementia	3.4%
613	Myotonic Disorders	3.4%
614	Central Nervous System Fungal Infections	3.4%
615	Conus Medullaris Syndrome	3.4%
616	Spinal Cord Vascular Diseases	3.4%
617	Diabetic Neuropathies	3.4%
618	Facial Injuries	3.4%
619	Facial Neuralgia	3.4%
620	Diabetic Amyotrophy	3.4%
621	Diabetic Autonomic Neuropathy	3.4%
622	Sleep Talking	3.4%
623	Manganese Poisoning	3.4%
624	Sleep Disorders, Intrinsic	3.4%
625	Orthostatic intolerance	3.4%
626	Lateral Medullary Syndrome	3.4%
627	Cerebral Palsy	3.4%
628	Epilepsies, Partial	3.4%
629	Epilepsy, Generalized	3.4%
630	Pseudotumor Cerebri	3.4%
631	Sciatic Neuropathy	3.4%
632	Hypertensive Encephalopathy	3.4%
633	Ulnar Neuropathies	3.4%
634	Lesion of Sciatic Nerve	3.4%
635	Simple Partial Seizures	3.4%
636	Epilepsy, Reflex	3.4%
637	Ulnar Neuritis	3.4%
638	Radial nerve compression	3.4%
639	Radial Tunnel Syndrome	3.4%
640	Peroneal Neuropathies	3.4%
641	Radial Neuropathy	3.4%
642	Median Neuropathy	3.4%
643	Sciatic Nerve Palsy	3.4%
644	Femoral Neuropathy	3.4%
645	Tibial Neuropathy	3.4%
646	Ulnar Nerve Palsy	3.4%
647	Postural Orthostatic Tachycardia Syndrome	3.4%
648	Radial nerve palsy	3.4%
649	Headache Disorders, Primary	3.4%
650	Headache Disorders, Secondary	3.4%
651	Medication overuse headache	3.4%
652	Anosmia	3.4%
653	Ataxia	3.4%
654	Athetosis	3.4%
655	Catalepsy	3.4%
656	Dystonia	3.4%
657	Hemiplegia	3.4%
658	Locked-In Syndrome	3.4%
659	Meningeal Neoplasms	3.4%
660	Muscle Hypertonia	3.4%
661	Muscle hypotonia	3.4%
662	Myoclonus	3.4%
663	Myotonia	3.4%
664	Neuralgia	3.4%
665	Paraplegia	3.4%
666	Pseudobulbar Palsy	3.4%
667	Quadriplegia	3.4%
668	Spasm	3.4%
669	Spastic Paraplegia	3.4%
670	Status Epilepticus	3.4%
671	Taste Disorders	3.4%
672	Tremor	3.4%
673	Monoplegia	3.4%
674	Hypokinesia	3.4%
675	Paraparesis	3.4%
676	Bradykinesia	3.4%
677	Waxy flexibility	3.4%
678	Action Tremor	3.4%
679	Resting Tremor	3.4%
680	Dysosmia	3.4%
681	Quadriparesis	3.4%
682	Mercury Poisoning, Nervous System	3.4%
683	Olfaction Disorders	3.4%
684	Myokymia	3.4%
685	Lead Poisoning, Nervous System	3.4%
686	Vestibular Neuronitis	3.4%
687	Somatosensory Disorders	3.4%
688	Neuropathic pain	3.4%
689	Hyperkinesia	3.4%
690	Intention tremor	3.4%
691	Auditory Perceptual Disorders	3.3%
692	Alexia	3.3%
693	Dyslexia	3.3%
694	Moyamoya Disease	3.2%
695	Neurofibrosarcoma	3.2%
696	Giant Cell Arteritis	3.1%
697	Temporal Arteritis	3.1%
698	Kearns-Sayre syndrome	3.1%
699	Acoustic Neuroma	3%
700	Hematoma, Subdural	3%
701	Hematoma, Epidural, Cranial	3%
702	Polyradiculopathy	3%
703	Post-Traumatic Headache	3%
704	Tension Headache	3%
705	Epilepsy, Complex Partial	3%
706	Migraine Disorders	3%
707	Abdominal Migraine	3%
708	Status Migrainosus	3%
709	Cervicogenic Headache	3%
710	Hand-Arm Vibration Syndrome	3%
711	Reflex, Abnormal	3%
712	Hyporeflexia	3%
713	Hyperreflexia	3%
714	Vision Disorders	3%
715	Metamorphopsia	3%
716	Visual Impairment	3%
717	Fibromyalgia	2.9%
718	Optic Neuropathy, Ischemic	2.9%
719	Anterior Ischemic Optic Neuropathy	2.9%
720	Central Nervous System Bacterial Infections	2.9%
721	Medial Tibial Stress Syndrome	2.9%
722	Facial Hemiatrophy	2.9%
723	Melkersson-Rosenthal Syndrome	2.9%
724	Mitochondrial Myopathies	2.9%
725	Anisocoria	2.9%
726	Confusion	2.9%
727	Facial paralysis	2.9%
728	Lethargy	2.9%
729	Memory Disorders	2.9%
730	Muscle Cramp	2.9%
731	Perceptual Disorders	2.9%
732	Psychomotor Disorders	2.9%
733	Tonic Pupil	2.9%
734	Eosinophilia-Myalgia Syndrome	2.9%
735	Anhedonia	2.9%
736	Disorientation	2.9%
737	Facial Paresis	2.9%
738	Memory Loss	2.9%
739	Hemisensory Neglect	2.9%
740	Dysacusis	2.9%
741	Pituitary Diseases	2.9%
742	Sleep Bruxism	2.9%
743	Muscular Atrophy	2.9%
744	Respiratory Paralysis	2.9%
745	Tetany	2.9%
746	Cluster Headache	2.8%
747	Migraine with Aura	2.8%
748	Familial Hemiplegic Migraine	2.8%
749	Chronic Paroxysmal Hemicrania	2.8%
750	SUNCT Syndrome	2.8%
751	Paroxysmal Hemicrania	2.8%
752	Thoracic Outlet Syndrome	2.8%
753	Hematoma, Subdural, Intracranial	2.8%
754	Hematoma, Subdural, Chronic	2.8%
755	Hematoma, Subdural, Acute	2.8%
756	Carotid Artery Diseases	2.8%
757	Brain Ischemia	2.8%
758	Esotropia	2.8%
759	Exotropia	2.8%
760	Hypotension, Orthostatic	2.8%
761	Sleep Apnea Syndromes	2.8%
762	Cerebrovascular accident	2.8%
763	Polymyositis	2.8%
764	Kluver-Bucy Syndrome	2.8%
765	Vasospasm, Intracranial	2.8%
766	Spinal Cord Ischemia	2.8%
767	Intracranial Arterial Diseases	2.8%
768	Post-Exercise Hypotension	2.8%
769	Disorders of Excessive Somnolence	2.8%
770	Sleep Initiation and Maintenance Disorders	2.8%
771	Night Terrors	2.8%
772	Somnambulism	2.8%
773	Trigeminal Nerve Disorder	2.8%
774	Transient Insomnia	2.8%
775	Sleep Paralysis	2.8%
776	Chronic Insomnia	2.8%
777	REM Sleep Behavior Disorder	2.8%
778	Hypersomnia	2.8%
779	Dysgeusia	2.8%
780	Formication	2.8%
781	Hyperalgesia	2.8%
782	Hyperesthesia	2.8%
783	Hypesthesia	2.8%
784	Language Disorders	2.8%
785	Numbness	2.8%
786	Paresthesia	2.8%
787	Paraparesis, Spastic	2.8%
788	Trismus	2.8%
789	Epilepsia Partialis Continua	2.8%
790	Hypogeusia	2.8%
791	Meningeal Carcinomatosis	2.8%
792	Brown-Sequard Syndrome	2.8%
793	Lockjaw	2.8%
794	Allodynia	2.8%
795	Lead Poisoning, Nervous System, Childhood	2.8%
796	Lead Poisoning, Nervous System, Adult	2.8%
797	Ageusia	2.8%
798	Tuberculosis, Central Nervous System	2.8%
799	Consciousness Disorders	2.6%
800	Mental Retardation	2.6%
801	Muscle Weakness	2.6%
802	Depressed Level of Consciousness	2.6%
803	Mental deficiency	2.6%
804	Intellectual Disability	2.6%
805	Bell Palsy	2.5%
806	Empty Sella Syndrome	2.5%
807	Hyperpituitarism	2.5%
808	Hypopituitarism	2.5%
809	Hypophysitis	2.5%
810	Catatonia	2.5%
811	Herpes Zoster Oticus	2.5%
812	Aphonia	2.5%
813	Sleep Deprivation	2.5%
814	Dysphonia	2.5%
815	Cerebral Arterial Diseases	2.5%
816	Vertebrobasilar Insufficiency	2.5%
817	Anterior Spinal Artery Syndrome	2.5%
818	Basilar Artery Stenosis	2.5%
819	Vertebral Artery Stenosis	2.5%
820	Sleep Apnea, Obstructive	2.5%
821	Sleep Apnea, Central	2.5%
822	Intracranial Hemorrhage, Hypertensive	2.5%
823	Transient Cerebral Ischemia	2.5%
824	Narcolepsy	2.5%
825	Trigeminal Neuralgia	2.5%
826	Kleine-Levin Syndrome	2.5%
827	Agraphia	2.5%
828	Anomia	2.5%
829	Cluttering	2.5%
830	Language Development Disorders	2.5%
831	Speech Disorders	2.5%
832	Syncope	2.5%
833	Stupor	2.5%
834	Dysgraphia	2.5%
835	Presyncope	2.5%
836	Dyslalia	2.5%
837	Eye Injuries	2.5%
838	Orbital Myositis	2.4%
839	Diplopia	2.4%
840	Muscle Rigidity	2.4%
841	Muscle Spasticity	2.4%
842	Scotoma	2.4%
843	Photophobia	2.4%
844	Cogwheel Rigidity	2.4%
845	Hemifacial Spasm	2.4%
846	Amaurosis	2.4%
847	Blindness	2.4%
848	Nuchal Rigidity	2.4%
849	Reye Syndrome	2.4%
850	Neuroaspergillosis	2.4%
851	Pyomyositis	2.4%
852	Intracranial Embolism and Thrombosis	2.4%
853	Hepatic Encephalopathy	2.4%
854	Agnosia	2.4%
855	Apraxias	2.4%
856	Hallucinations	2.4%
857	Hemianopsia	2.4%
858	Hyperacusis	2.4%
859	Tinnitus	2.4%
860	Visual Agnosia	2.4%
861	Anosognosia	2.4%
862	Wernicke-Korsakoff Syndrome	2.4%
863	Phonophobia	2.4%
864	Hearing Loss	2.4%
865	Hyperprolactinemia	2.4%
866	Sarcopenia	2.4%
867	Subclavian Steal Syndrome	2.3%
868	Pick Disease of the Brain	2.3%
869	Cataplexy	2.3%
870	Aphasia	2.3%
871	Articulation Disorders	2.3%
872	Echolalia	2.3%
873	Stuttering	2.3%
874	Dysphasia	2.3%
875	Dysarthria	2.3%
876	Myalgia	2.2%
877	Waterhouse-Friderichsen Syndrome	2.2%
878	Pseudorabies	2.2%
879	Eye Burns	2.2%
880	Malaria, Cerebral	2.1%
881	Carotid Stenosis	2.1%
882	Intracranial Aneurysm	2.1%
883	Neurocysticercosis	2.1%
884	Amaurosis Fugax	2.1%
885	Blindness, Cortical	2.1%
886	Dyscalculia	2.1%
887	Intracranial Arteriosclerosis	2.1%
888	Cerebral Atherosclerosis	2.1%
889	Subarachnoid Hemorrhage	2.1%
890	Cerebral Arteriosclerosis	2.1%
891	Cerebral Hemorrhage	2.1%
892	Cerebral Thrombosis	2.1%
893	Intracranial Embolism	2.1%
894	Intracranial Thrombosis	2.1%
895	Deafness	2.1%
896	Hearing Loss, Sudden	2.1%
897	Gerstmann Syndrome	2.1%
898	Hearing Loss, Bilateral	2.1%
899	Hearing Loss, High-Frequency	2.1%
900	Hearing Loss, Mixed Conductive-Sensorineural	2.1%
901	Prosopagnosia	2.1%
902	Apraxia, Ideomotor	2.1%
903	Charles Bonnet Syndrome	2.1%
904	Hearing Loss, Unilateral	2.1%
905	Complete Hearing Loss	2.1%
906	Alien Hand Syndrome	2.1%
907	Deaf Mutism	2.1%
908	Amnesia	2.1%
909	Delirium	2.1%
910	Dissociative Amnesia	2.1%
911	Color blindness	2.1%
912	Global Amnesia	2.1%
913	Meningioma	2.1%
914	Neurosyphilis	2.1%
915	Mutism	2%
916	Selective Mutism	2%
917	Acromegaly	2%
918	Hoarseness	2%
919	Cerebral Amyloid Angiopathy	2%
920	Alcohol Withdrawal Delirium	2%
921	Sinus Thrombosis, Intracranial	2%
922	Alexia, Pure	1.9%
923	Cavernous Sinus Thrombosis	1.9%
924	Sagittal Sinus Thrombosis	1.9%
925	Dermatomyositis	1.9%
926	Corneal Scar	1.9%
927	Retrograde amnesia	1.9%
928	Amnesia, Anterograde	1.9%
929	Carotid Artery Thrombosis	1.9%
930	Wernicke Encephalopathy	1.8%
931	AIDS Dementia Complex	1.8%
932	Phantom pain	1.8%
933	Phantom Limb Pain	1.8%
934	Lyme Neuroborreliosis	1.8%
935	Corneal Perforation	1.8%
936	Nelson Syndrome	1.7%
937	Prolactinoma	1.6%
938	Growth Hormone-Secreting Pituitary Adenoma	1.6%

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