MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hypoalphalipoproteinemias

(UMLS:C0473527)

Definition:: Conditions with abnormally low levels of ALPHA-LIPOPROTEINS (high-density lipoproteins) in the blood. Hypoalphalipoproteinemia can be associated with mutations in genes encoding APOLIPOPROTEIN A-I; LECITHIN CHOLESTEROL ACYLTRANSFERASE; and ATP-BINDING CASSETTE TRANSPORTERS.
UMLS ID:: C0473527
MeSH ID:: D052456

Classification 1:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.565.398.500.330

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.584.500.875.330|C18.452.648.398.500.330

Synonym(s)

Hypoalphalipoproteinemias

Hypoalphalipoproteinaemia

Hypoalphalipoproteinemia

hypoalphalipoproteinemia

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Atenolol	1981077	CTD
2	Bezafibrate	9118820	CTD
3	Chlorogenic Acid	20696151	CTD
4	Danazol	15806011	CTD
5	Ezetimibe	20152243	CTD
6	Gemfibrozil	11701466 15657157	CTD
7	Lovastatin	8238075	CTD
8	Niacinamide	20696151	CTD
9	Niacin	View details 7942568 11498460 11701466 11757504 12094204 15537681 15539964 15657157 16407706 18993152 20152243	CTD
10	Pravastatin	8238075	CTD
11	Rosuvastatin Calcium	15539964	CTD
12	Simvastatin	11498460 11757504 20152243	CTD
13	Streptozocin	20696151	CTD
14	tetrahydrocurcumin	20696151	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Smith-Lemli-Opitz Syndrome	37.4%
2	Hyperlipidemia, Familial Combined	35.9%
3	Hyperlipoproteinemia Type IV	34.8%
4	Hyperlipoproteinemia Type V	34.8%
5	Hyperlipoproteinemia Type III	33.5%
6	Amino Acid Metabolism, Inborn Errors	27.5%
7	Carbohydrate Metabolism, Inborn Errors	27.5%
8	Metal Metabolism, Inborn Errors	27.5%
9	Progeria	27.5%
10	Lysosomal Storage Diseases	27.5%
11	Peroxisomal Disorders	27.5%
12	Brain Diseases, Metabolic, Inborn	26.7%
13	Wasting Syndrome	23.9%
14	Pseudohypoparathyroidism	22.5%
15	Neuronal Ceroid-Lipofuscinoses	22.3%
16	Acid-Base Imbalance	22%
17	Calcium Metabolism Disorders	22%
18	Iron Metabolism Disorders	22%
19	Phosphorus Metabolism Disorders	22%
20	Water-Electrolyte Imbalance	22%
21	Mitochondrial Diseases	22%
22	Glucose Metabolism Disorders	22%
23	Lipodystrophy	21.7%
24	Galactosemias	21.4%
25	Urea Cycle Disorders, Inborn	21.4%
26	Tyrosinemias	21.4%
27	Leigh Disease	21.3%
28	Cytochrome-c Oxidase Deficiency	21%
29	Xanthomatosis	20.1%
30	Xanthoma	20.1%
31	Hypercalcemia	19.4%
32	Hypocalcemia	19.4%
33	Milk-Alkali Syndrome	19.4%
34	Hyperhomocysteinemia	19.2%
35	Hyperphosphaturia	19.2%
36	Werner Syndrome	18.7%
37	Lactose Intolerance	18.6%
38	Osteopenia	17.9%
39	Brain Diseases, Metabolic	17.7%
40	Carbamoyl-Phosphate Synthase I Deficiency Disease	17.5%
41	Menkes Kinky Hair Syndrome	17.1%
42	Gaucher Disease	17%
43	Homocystinuria	16.6%
44	Glycogen storage disease type II	16.4%
45	Lipomatosis	16.4%
46	Alkaptonuria	16.3%
47	Glycogen Storage Disease	16.3%
48	Hypophosphatasia	16.3%
49	Propionic acidemia	16.3%
50	Dihydropyrimidine Dehydrogenase Deficiency	16.3%
51	Cystinosis	16.3%
52	Sjogren-Larsson Syndrome	16%
53	Hepatolenticular Degeneration	15.7%
54	Zellweger Syndrome	15.6%
55	Adrenoleukodystrophy	15.5%
56	Fabry Disease	15.3%
57	Refsum Disease	15.2%
58	Rickets	14.6%
59	Amyloid Neuropathies, Familial	14.5%
60	Nutrition Disorders	14.3%
61	Hypercholesterolemia	14.3%
62	Hyperlipoproteinemias	14.3%
63	Hypertriglyceridemia	14.3%
64	Renal tubular acidosis	13.8%
65	Mucopolysaccharidosis III	13.5%
66	Albinism	13.3%
67	Niemann-Pick Disease, Type C	12.9%
68	Familial Hypophosphatemic Rickets	12.5%
69	Mucopolysaccharidosis II	12.5%
70	Tay-Sachs Disease	12.4%
71	Acidosis	12%
72	Alkalosis	12%
73	Amyloidosis	12%
74	Calcinosis	12%
75	Hyperglycemia	12%
76	Hyperinsulinism	12%
77	Hyperkalemia	12%
78	Hypernatremia	12%
79	Hypoglycemia	12%
80	Hypokalemia	12%
81	Hyponatremia	12%
82	Hypophosphatemia	12%
83	Metabolic acidosis	12%
84	Iron Overload	12%
85	Ichthyosis, X-Linked	12%
86	Familial Periodic Paralysis	11.9%
87	Cockayne Syndrome	11.8%
88	Renal Aminoacidurias	11.6%
89	Fanconi Syndrome	11.6%
90	Pseudohypoaldosteronism	11.6%
91	Liddle Syndrome	11.6%
92	Bloom Syndrome	11.3%
93	Glycosuria, Renal	11%
94	Lipid Metabolism Disorders	11%
95	Antley-Bixler Syndrome Phenotype	10.8%
96	Glycogen Storage Disease Type I	10.8%
97	Glycogen Storage Disease Type V	10.8%
98	MELAS Syndrome	10.8%
99	Porphyrias, Hepatic	10.6%
100	Congenital Hyperinsulinism	10.6%
101	Gout	10.4%
102	Fanconi Anemia	10.3%
103	Diabetes Mellitus	10.1%
104	Dehydration	9.8%
105	Water Intoxication	9.8%
106	Achlorhydria	9.7%
107	Osteoporosis	9.7%
108	Bone Demineralization, Pathologic	9.7%
109	Post-Traumatic Osteoporosis	9.7%
110	Mitochondrial Encephalomyopathies	9.7%
111	Adiposis Dolorosa	9.6%
112	Celiac Disease	9.6%
113	Sprue, Tropical	9.6%
114	Steatorrhea	9.6%
115	Sprue	9.6%
116	Ataxia Telangiectasia	9.4%
117	Neoplastic Syndromes, Hereditary	9.2%
118	Canavan Disease	8.9%
119	Alexander Disease	8.9%
120	Multiple Epiphyseal Dysplasia	8.9%
121	Osteochondrodysplasias	8.9%
122	Pelger-Huet Anomaly	8.9%
123	Myasthenic Syndromes, Congenital	8.9%
124	Osteomalacia	8.8%
125	CHARGE Syndrome	8.8%
126	Cystic Fibrosis	8.7%
127	HIV-Associated Lipodystrophy Syndrome	8.6%
128	Mitochondrial Myopathies	8.2%
129	Myelinolysis, Central Pontine	8.2%
130	HIV Wasting Syndrome	8.1%
131	Glycosuria	8.1%
132	Reye Syndrome	8.1%
133	Hepatic Encephalopathy	8%
134	Diabetic Ketoacidosis	8%
135	Friedreich Ataxia	7.8%
136	Hypokalemic periodic paralysis	7.8%
137	Optic Atrophy, Hereditary, Leber	7.7%
138	Aicardi's syndrome	7.7%
139	Cystinuria	7.7%
140	Dwarfism	7.6%
141	Nail-Patella Syndrome	7.6%
142	Xeroderma Pigmentosum	7.5%
143	Muscular Dystrophy	7.4%
144	Osteogenesis Imperfecta	7.4%
145	Child Nutrition Disorders	7.3%
146	Hypervitaminosis A	7.3%
147	Infant Nutrition Disorders	7.3%
148	Malnutrition	7.3%
149	Deformity	7.2%
150	Acidosis, Lactic	7.2%
151	Calciphylaxis	7.2%
152	Hemosiderosis	7.2%
153	Ketosis	7.2%
154	Ketonuria	7.2%
155	Ketoacidosis	7.2%
156	Ketonemia	7.2%
157	Vascular calcification	7.2%
158	Necrobiosis Lipoidica Diabeticorum	7%
159	Anemia, Sickle Cell	6.9%
160	Thalassemia	6.9%
161	Muscular Dystrophy, Duchenne	6.9%
162	Arthritis, Gouty	6.8%
163	Beckwith-Wiedemann Syndrome	6.8%
164	Wolf-Hirschhorn Syndrome	6.8%
165	Nesidioblastosis	6.7%
166	Wernicke Encephalopathy	6.6%
167	Autoimmune Lymphoproliferative Syndrome	6.4%
168	Kernicterus	6.4%
169	Prader-Willi Syndrome	6.3%
170	Angioedemas, Hereditary	6.3%
171	Variegate Porphyria	6.2%
172	Acute intermittent porphyria	6.2%
173	Porphyria Cutanea Tarda	6.2%
174	Renal Osteodystrophy	6.2%
175	Renal rickets	6.2%
176	Familial Mediterranean Fever	6%
177	Dyslipidemias	6%
178	Fragile X Syndrome	6%
179	Smith-Magenis syndrome	5.9%
180	Marfan Syndrome	5.8%
181	Fetal Diseases	5.8%
182	Cri-du-Chat Syndrome	5.8%
183	Down Syndrome	5.8%
184	Trisomy 21	5.8%
185	Acidosis, Respiratory	5.8%
186	Alkalosis, Respiratory	5.8%
187	Insulin Resistance	5.8%
188	Osteoporosis, Postmenopausal	5.8%
189	Wiskott-Aldrich Syndrome	5.4%
190	Kartagener Syndrome	5.3%
191	Alstrom Syndrome	5.3%
192	Kallmann Syndrome	5.2%
193	Kearns-Sayre syndrome	5.2%
194	Ectodermal Dysplasia	5.1%
195	Aplasia Cutis Congenita	5.1%
196	Holoprosencephaly	5.1%
197	Gestational Diabetes	5%
198	Latent Autoimmune Diabetes in Adults	5%
199	Diabetes Mellitus, Experimental	4.9%
200	Myotonic Dystrophy	4.9%
201	Nephrocalcinosis	4.8%
202	Tetany	4.8%
203	Hypolipoproteinemias	4.8%
204	Rett Syndrome	4.8%
205	Cerebral Amyloid Angiopathy	4.8%
206	Polycystic Kidney Diseases	4.6%
207	Williams Syndrome	4.6%
208	Rubinstein-Taybi Syndrome	4.6%
209	Tuberous Sclerosis	4.5%
210	Primary Ciliary Dyskinesia	4.4%
211	Retinal Dysplasia	4.2%
212	Primary amyloidosis	4.2%
213	Aniridia	4.2%
214	Cutis Laxa	4.1%
215	Sickle Cell Trait	4.1%
216	Epidermolysis Bullosa	4.1%
217	Retinitis Pigmentosa	4.1%
218	Pigmentary retinopathy	4.1%
219	Porokeratosis	4.1%
220	Keratoderma, Palmoplantar	4.1%
221	Chronic granulomatous disease	4%
222	Deficiency Diseases	4%
223	Starvation	4%
224	Refeeding Syndrome	4%
225	Welander Distal Myopathy	4%
226	Meconium Aspiration Syndrome	3.8%
227	Abdominal Cramps	3.7%
228	Abnormalities, Drug-Induced	3.7%
229	Amniotic Band Syndrome	3.7%
230	Asphyxia Neonatorum	3.7%
231	Infant, Premature, Diseases	3.7%
232	Situs Inversus	3.7%
233	Infantile Colic	3.7%
234	Amyotrophic Lateral Sclerosis	3.7%
235	Duane Retraction Syndrome	3.6%
236	Peutz-Jeghers Syndrome	3.5%
237	Myotonia Congenita	3.5%
238	Thrombasthenia	3.5%
239	Antithrombin III Deficiency	3.5%
240	Protein C Deficiency	3.5%
241	Afibrinogenemia	3.5%
242	Dystonia Musculorum Deformans	3.5%
243	Factor VII Deficiency	3.5%
244	Factor X Deficiency	3.5%
245	Factor XII Deficiency	3.5%
246	Hemophilia A	3.5%
247	Activated Protein C Resistance	3.5%
248	Factor II deficiency	3.5%
249	Factor VIII Deficiency	3.5%
250	Factor V deficiency	3.5%
251	Factor XI Deficiency	3.5%
252	Hypoprothrombinemias	3.5%
253	Lafora Disease	3.4%
254	Unverricht-Lundborg Syndrome	3.4%
255	Anemia, Diamond-Blackfan	3.4%
256	Pseudoxanthoma Elasticum	3.3%
257	Xeroderma	3.3%
258	Mobius Syndrome	3.3%
259	Acute Chest Syndrome	3.3%
260	CREST Syndrome	3.2%
261	Hypoalphalipoproteinemias	3.2%
262	Multiple Endocrine Neoplasia	3.1%
263	Congenital Hypothyroidism	3.1%
264	Eye Abnormalities	3.1%
265	Cardiovascular Abnormalities	3.1%
266	Dermatitis, Atopic	3.1%
267	Skin Abnormalities	3%
268	Lymphatic Abnormalities	3%
269	Congenital Microtia	3%
270	Anemia, Neonatal	3%
271	Persistent Fetal Circulation Syndrome	3%
272	Congenital diaphragmatic hernia	2.9%
273	Umbilical hernia	2.9%
274	Frontotemporal dementia	2.7%
275	Polycystic Kidney, Autosomal Dominant	2.7%
276	Behcet Syndrome	2.7%
277	Basal Cell Nevus Syndrome	2.7%
278	Urogenital Abnormalities	2.6%
279	Neonatal Abstinence Syndrome	2.5%
280	Classical Lissencephalies and Subcortical Band Heterotopias	2.5%
281	Hyperkeratosis, Epidermolytic	2.5%
282	Fetal Growth Retardation	2.5%
283	Fetal Hypoxia	2.5%
284	Congenital nystagmus	2.5%
285	Fetal Alcohol Spectrum Disorders	2.5%
286	Huntington Disease	2.4%
287	Toxoplasmosis, Congenital	2.4%
288	Syphilis, Congenital	2.4%
289	Charcot-Marie-Tooth Disease	2.4%
290	Papillon-Lefevre Disease	2.4%
291	Kwashiorkor	2.4%
292	Magnesium Deficiency	2.4%
293	Potassium Deficiency	2.4%
294	Protein Deficiency	2.4%
295	Avitaminosis	2.4%
296	Obesity	2.3%
297	Nephroblastoma	2.2%
298	Anencephaly	2.2%
299	Chorioamnionitis	2.1%
300	Adenomatous Polyposis Coli	2%
301	Prune Belly Syndrome	2%
302	Twins, Conjoined	2%
303	Waardenburg Syndrome	2%
304	Maxillofacial Abnormalities	1.9%
305	Dural Arteriovenous Fistula	1.9%
306	Dextrocardia	1.9%
307	Abnormalities, Radiation-Induced	1.8%
308	Multiple Endocrine Neoplasia Type 1	1.8%
309	Hydrops Fetalis	1.8%
310	Anophthalmos	1.6%
311	Anus, Imperforate	1.6%
312	Hydranencephaly	1.6%
313	Microphthalmos	1.6%
314	Neural Tube Defects	1.6%
315	Paralysis, Obstetric	1.6%
316	Retinopathy of Prematurity	1.6%
317	Tethered Cord Syndrome	1.6%
318	Iniencephaly	1.6%
319	Craniorachischisis	1.6%
320	Limb Deformities, Congenital	1.6%
321	Exencephaly	1.6%
322	Septo-Optic Dysplasia	1.6%
323	Craniofacial Abnormalities	1.6%
324	Cortical Dysplasia	1.6%
325	Malformations of Cortical Development	1.6%
326	Anorectal Malformations	1.6%
327	Ophthalmia Neonatorum	1.6%
328	Bronchopulmonary Dysplasia	1.6%
329	Klinefelter Syndrome	1.6%
330	Ascorbic Acid Deficiency	1.6%
331	Vitamin A Deficiency	1.6%
332	Vitamin D Deficiency	1.6%
333	Vitamin E Deficiency	1.6%
334	Marasmus	1.6%
335	Obesity, Abdominal	1.6%
336	Turner Syndrome	1.5%
337	Scimitar Syndrome	1.5%
338	Blepharophimosis	1.4%
339	Laryngostenosis	1.4%
340	Mouth Abnormalities	1.4%
341	Respiratory Distress Syndrome, Newborn	1.4%
342	Esophageal Atresia	1.4%
343	Intestinal Atresia	1.4%
344	Horseshoe Kidney	1.4%
345	Pectus excavatum	1.4%
346	Klippel-Feil Syndrome	1.4%
347	Gastroschisis	1.4%
348	Synostosis	1.4%
349	Pediatric Obesity	1.4%
350	Acrodermatitis	1.4%
351	Lymphangiectasis, Intestinal	1.4%
352	Gianotti-Crosti Syndrome	1.4%
353	Craniosynostosis	1.2%
354	Syndactyly	1.2%
355	Brachycephaly	1.2%
356	Arthrogryposis	1.2%
357	Choanal Atresia	1.2%
358	Tracheobronchomegaly	1.2%
359	Laryngocele	1.2%
360	Folic Acid Deficiency	1.2%
361	Pellagra	1.2%
362	Thiamine Deficiency	1.2%
363	Vitamin B 12 Deficiency	1.2%
364	Vitamin B 6 Deficiency	1.2%
365	Pyridoxine Deficiency	1.2%
366	Choledochal Cyst	1.2%
367	Hermaphroditism	1.2%
368	Disorders of Sex Development	1.2%
369	Cryptorchidism	1.2%
370	Hypospadias	1.2%
371	Central Nervous System Cysts	1.2%
372	Denys-Drash Syndrome	1.2%
373	Dandy-Walker Syndrome	1.2%
374	Leukomalacia, Periventricular	1.2%
375	POEMS Syndrome	1.2%
376	Microcephaly	1.1%
377	Macrocephaly	1.1%
378	Noonan Syndrome	1.1%
379	Vitamin K Deficiency	1.1%
380	Laryngomalacia	1%
381	Pectus carinatum	1%
382	Bladder Exstrophy	1%
383	Epispadias	1%
384	Multicystic Dysplastic Kidney	1%
385	Beriberi	1%
386	Acrocephalosyndactylia	1%
387	Amelia	1%
388	Arachnodactyly	1%
389	Ectopia Cordis	1%
390	Ectromelia	1%
391	Hemimelia	1%
392	Meningomyelocele	1%
393	Phocomelia	1%
394	Sirenomelia	1%
395	Spina Bifida	1%
396	Polydactyly	1%
397	Brachydactyly	1%
398	Plagiocephaly	1%
399	Lower Extremity Deformities, Congenital	1%
400	Upper Extremity Deformities, Congenital	1%
401	Single umbilical artery	1%
402	Jaw Abnormalities	0.9%
403	Porencephaly	0.9%
404	Cleft Palate	0.9%
405	Aortic coarctation	0.8%
406	Cor Triatriatum	0.8%
407	Coronary Vessel Anomalies	0.8%
408	Dental Enamel Hypoplasia	0.8%
409	Patent ductus arteriosus	0.8%
410	Ebstein Anomaly	0.8%
411	Heart Septal Defects	0.8%
412	Hyaline Membrane Disease	0.8%
413	Hypodontia	0.8%
414	Macrostomia	0.8%
415	Meningocele	0.8%
416	Microstomia	0.8%
417	Tetralogy of Fallot	0.8%
418	Transposition of Great Vessels	0.8%
419	Hypoplastic Left Heart Syndrome	0.8%
420	May-Thurner Syndrome	0.8%
421	Encephalocele	0.8%
422	Craniofacial Dysostosis	0.8%
423	Scurvy	0.8%
424	Wolff-Parkinson-White Syndrome	0.8%
425	Poland Syndrome	0.8%
426	Anemia, Pernicious	0.8%
427	Long QT Syndrome	0.7%
428	Platybasia	0.7%
429	Tricuspid Atresia	0.7%
430	Arrhythmogenic Right Ventricular Dysplasia	0.7%
431	Gonadal Dysgenesis	0.7%
432	Bronchomalacia	0.7%
433	Adrenogenital Syndrome	0.7%
434	Tracheomalacia	0.7%
435	Ovotesticular Disorders of Sex Development	0.7%
436	Dermal Sinus	0.6%
437	Spina Bifida Cystica	0.6%
438	Spina Bifida Occulta	0.6%
439	Lissencephaly	0.6%
440	Polymicrogyria	0.6%
441	Pachygyria	0.6%
442	Schizencephaly	0.6%
443	Periventricular Nodular Heterotopia	0.6%
444	Micrognathism	0.6%
445	Pierre Robin Syndrome	0.6%
446	Hyperandrogenism	0.6%
447	Retrognathia	0.6%
448	Aortopulmonary Septal Defect	0.5%
449	Double Outlet Right Ventricle	0.5%
450	Endocardial Cushion Defects	0.5%
451	Myocardial bridging	0.5%
452	Aorticopulmonary Septal Defect	0.5%
453	Subacute Combined Degeneration	0.5%
454	Prognathism	0.5%
455	Mandibulofacial Dysostosis	0.5%
456	Romano-Ward Syndrome	0.5%
457	Truncus Arteriosus, Persistent	0.4%
458	Goldenhar Syndrome	0.4%
459	Arteriovenous fistula	0.4%
460	Talipes	0.3%
461	Congenital clubfoot	0.3%
462	Vertical Talus	0.3%

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