MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

(UMLS:C2717865)

Definition:: Group of systemic vasculitis with a strong association with ANCA. The disorders are characterized by necrotizing inflammation of small and medium size vessels, with little or no immune-complex deposits in vessel walls.
UMLS ID:: C2717865
MeSH ID:: D056648

Classification 1:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.940.897.249

Classification 2:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.111.193

Synonym(s)

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Allopurinol	10693882	CTD
2	Atorvastatin	18839266	CTD
3	Azathioprine	18839266	CTD
4	Carbimazole	8542214 19263707	CTD
5	Cyclophosphamide	16188901	CTD
6	Hydralazine	10693882 17954295	CTD
7	Isotretinoin	9085448	CTD
8	Methimazole	View details 11802538 12353714 15175822 20061292	CTD
9	Methylprednisolone	18839266	CTD
10	Minocycline	12900849	CTD
11	Mycophenolic Acid	12078944 16188901	CTD
12	Penicillamine	8592607 10693882	CTD
13	Phenytoin	8671794	CTD
14	Prednisolone	8542214 8671794	CTD
15	Propylthiouracil	View details 8103148 8201492 8542214 8956314 9575062 10025935 10505168 10693882 10786355 10792251 10804735 10846402 10969508 11075728 12110741 12137604 12232461 12390348 14692444 15114849 15175822 15189700 15687828 15730404 15730621 15760792 15944836 16018796 16207324 16435062 16491416 16758084 16847204 16887463 17070108 17161817 17365943 17371473 17415292 17472842 17954295 17985400 18044264 18676500 19260531 19493451 19740576 20061292 20168071 20482568	CTD
16	Sulfasalazine	10693882	CTD
17	Thioridazine	12452885	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Polyarteritis Nodosa	29.1%
2	Antiphospholipid Syndrome	27.6%
3	Aortitis	25.2%
4	Periphlebitis	25.2%
5	Phlebitis	25.2%
6	Thromboangiitis Obliterans	25.2%
7	Arteritis	23.6%
8	Vasculitis, Central Nervous System	23.1%
9	Vasculitis, Leukocytoclastic, Cutaneous	22.7%
10	Rheumatoid Vasculitis	22.6%
11	Lupus Erythematosus, Systemic	20.9%
12	Overlap syndrome	20.9%
13	Addison Disease	20.5%
14	Pemphigus	20.5%
15	Autoimmune thyroiditis	20.5%
16	Primary Adrenal Insufficiency	20.5%
17	Autoimmune hepatitis	20.3%
18	Malignant Atrophic Papulosis	20.1%
19	Shwartzman Phenomenon	20%
20	Retinal Vasculitis	17.9%
21	Giant Cell Arteritis	17.9%
22	Temporal Arteritis	17.9%
23	Myocardial Ischemia	17.4%
24	Aneurysm	17.2%
25	Angiomatosis	17.2%
26	Aortic Diseases	17.2%
27	Arterial Occlusive Diseases	17.2%
28	Hyperemia	17.2%
29	Hypotension	17.2%
30	Superior Vena Cava Syndrome	17.2%
31	Telangiectasis	17.2%
32	Venous Insufficiency	17.2%
33	Peripheral Vascular Diseases	17.2%
34	Embolism and Thrombosis	17.2%
35	Angiodysplasia	17.2%
36	Capillary Leak Syndrome	17.2%
37	Prehypertension	17.2%
38	Autoimmune Lymphoproliferative Syndrome	17.1%
39	Latent Autoimmune Diabetes in Adults	16.4%
40	Dermatitis Herpetiformis	16.3%
41	Thrombophlebitis	16.1%
42	Endarteritis	15.6%
43	Aortic Aneurysm	15.1%
44	Leriche Syndrome	15.1%
45	Hypersensitivity	14.5%
46	Immunologic Deficiency Syndromes	14.5%
47	Immunoproliferative Disorders	14.5%
48	Immune reconstitution syndrome	14.5%
49	Immune Reconstitution Inflammatory Syndrome	14.5%
50	Mucocutaneous Lymph Node Syndrome	14.3%
51	Rheumatoid Arthritis	13.7%
52	Juvenile arthritis	13.7%
53	Kounis Syndrome	13.6%
54	Graves Disease	13.6%
55	Vascular System Injuries	13.5%
56	Angioedema	13.4%
57	Anti-Glomerular Basement Membrane Disease	13.3%
58	Retinal Vein Occlusion	13.3%
59	Lupus Vasculitis, Central Nervous System	13.3%
60	Takayasu Arteritis	13.2%
61	Compartment syndromes	13%
62	Hepatic Veno-Occlusive Disease	13%
63	Peliosis Hepatis	13%
64	Varicocele	13%
65	Cerebrovascular Disorders	12.8%
66	Diabetic Angiopathies	12.8%
67	Reperfusion Injury	12.8%
68	Splenic Infarction	12.8%
69	Cerebrovascular Insufficiency	12.8%
70	Vascular Neoplasms	12.8%
71	Spinal Cord Vascular Diseases	12.8%
72	Vasoplegia	12.8%
73	Hemorrhoids	12.7%
74	Thoracic Outlet Syndrome	12.7%
75	Postphlebitic Syndrome	12.5%
76	Myasthenia Gravis, Autoimmune, Experimental	12.3%
77	Myasthenia Gravis	12.2%
78	Uveomeningoencephalitic Syndrome	12.2%
79	Autoimmune thrombocytopenia	11.8%
80	Immune thrombocytopenic purpura	11.8%
81	Myocardial Reperfusion Injury	11.4%
82	Coronary Aneurysm	11.3%
83	Heart Diseases	10.8%
84	Transfusion Reaction	10.8%
85	Hypotensive Transfusion Reaction	10.8%
86	Hand-Arm Vibration Syndrome	10.6%
87	Blue Toe Syndrome	10.6%
88	Optic Neuropathy, Ischemic	10.3%
89	Anterior Ischemic Optic Neuropathy	10.3%
90	Mesenteric vascular insufficiency	10.3%
91	Stiff-Person Syndrome	10.3%
92	Polyradiculoneuropathy	10.2%
93	Polyradiculoneuritis	10.2%
94	Aneurysm, Dissecting	10.1%
95	Arteriosclerosis	10.1%
96	Embolism	10.1%
97	Erythromelalgia	10.1%
98	Fibromuscular Dysplasia	10.1%
99	Malignant Hypertension	10.1%
100	Raynaud Disease	10.1%
101	Thromboembolism	10.1%
102	Thrombosis	10.1%
103	Essential Hypertension	10.1%
104	Aneurysm, Ruptured	10.1%
105	Iliac Aneurysm	10.1%
106	Pulmonary artery stenosis	10.1%
107	White Coat Hypertension	10.1%
108	Embolus	10.1%
109	Coronary heart disease	10.1%
110	Myocardial Infarction	10.1%
111	Acute Coronary Syndrome	10.1%
112	Colitis, Ischemic	10%
113	Aortic Rupture	10%
114	Multiple Sclerosis	10%
115	Felty Syndrome	9.9%
116	Intracranial Embolism and Thrombosis	9.9%
117	Aortic Aneurysm, Abdominal	9.9%
118	Aortic Aneurysm, Thoracic	9.9%
119	Carotid Stenosis	9.9%
120	Intracranial Aneurysm	9.9%
121	Lupus Nephritis	9.9%
122	Neuromyelitis Optica	9.4%
123	Leukoencephalitis, Acute Hemorrhagic	9.3%
124	Coronary Thrombosis	9.2%
125	Coronary Artery Disease	9.2%
126	Immune Complex Diseases	9.2%
127	Latex allergy	9.2%
128	Moyamoya Disease	9.1%
129	Arteriovenous fistula	9%
130	Carotid Artery Thrombosis	9%
131	Multiple Sclerosis, Chronic Progressive	8.9%
132	Multiple Sclerosis, Relapsing-Remitting	8.9%
133	Behcet Syndrome	8.8%
134	Multiple Myeloma	8.7%
135	Cryoglobulinemia	8.3%
136	Encephalomyelitis, Acute Disseminated	8.3%
137	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	8.3%
138	Neuritis, Autoimmune, Experimental	8.2%
139	Glomerulonephritis, Membranoproliferative	8.2%
140	Pregnancy Complications, Cardiovascular	8.1%
141	Cardiovascular Abnormalities	8.1%
142	May-Thurner Syndrome	8%
143	Angina Pectoris	8%
144	Intracranial Arteriosclerosis	7.9%
145	Cerebral Atherosclerosis	7.9%
146	Cerebral Arteriosclerosis	7.9%
147	Lemierre Syndrome	7.8%
148	Retinal Artery Occlusion	7.7%
149	Scimitar Syndrome	7.7%
150	Hypertensive Retinopathy	7.7%
151	Anterior Compartment Syndrome	7.6%
152	Lambert-Eaton Myasthenic Syndrome	7.6%
153	Gastric Antral Vascular Ectasia	7.6%
154	Abdominal Compartment Syndrome	7.6%
155	Carotid Artery Diseases	7.5%
156	Brain Ischemia	7.5%
157	Angioedemas, Hereditary	7.5%
158	Hypotension, Orthostatic	7.5%
159	Cerebrovascular accident	7.5%
160	Varicose Ulcer	7.5%
161	Vasospasm, Intracranial	7.5%
162	Spinal Cord Ischemia	7.5%
163	Intracranial Arterial Diseases	7.5%
164	Primary Graft Dysfunction	7.5%
165	Post-Exercise Hypotension	7.5%
166	Sicca Syndrome	7.4%
167	Sjogren's Syndrome	7.4%
168	Embolism, Amniotic Fluid	7.4%
169	Environmental Illness	7.2%
170	Guillain-Barre Syndrome	7.1%
171	Lymphoproliferative Disorders	7%
172	Cerebral Thrombosis	6.9%
173	Intracranial Embolism	6.9%
174	Intracranial Thrombosis	6.9%
175	Paraproteinemias	6.8%
176	Lymphopenia	6.8%
177	anaphylaxis	6.7%
178	Food Allergy	6.7%
179	Anaphylactic shock	6.7%
180	Hereditary Angioedema Type III	6.7%
181	Hereditary Angioedema Types I and II	6.7%
182	Arteriosclerosis Obliterans	6.7%
183	Atherosclerosis	6.7%
184	Air Embolism	6.7%
185	Venous Thrombosis	6.7%
186	Deep Vein Thrombosis	6.7%
187	Primary amyloidosis	6.7%
188	Venous Thromboembolism	6.7%
189	Monoclonal Gammopathy of Undetermined Significance	6.6%
190	Coronary Occlusion	6.6%
191	Microvascular Angina	6.6%
192	Coronary Stenosis	6.6%
193	ST segment elevation myocardial infarction	6.6%
194	Brain Infarction	6.5%
195	Ataxia Telangiectasia	6.4%
196	Waldenstrom Macroglobulinemia	6.2%
197	CREST Syndrome	6.1%
198	Mesenteric Vascular Occlusion	6.1%
199	Diabetic Retinopathy	6.1%
200	Sturge-Weber Syndrome	6.1%
201	Serum Sickness	6%
202	Livedo Reticularis	6%
203	Renal hypertension	6%
204	Renal Artery Obstruction	6%
205	Renal Artery Stenosis	6%
206	Hemangioma, Cavernous	6%
207	Basal Ganglia Cerebrovascular Disease	6%
208	Vascular Headaches	5.9%
209	Scurvy	5.9%
210	Thrombocytopenic purpura	5.8%
211	Cardiac Tamponade	5.7%
212	Endocarditis	5.7%
213	Cardiac Arrest	5.7%
214	Heart failure	5.7%
215	Pericardial effusion	5.7%
216	Pericarditis	5.7%
217	Pneumopericardium	5.7%
218	Cor pulmonale	5.7%
219	Ventricular Outflow Obstruction	5.7%
220	Ventricular Dysfunction	5.7%
221	Cardiomyopathies	5.7%
222	Pleuropericarditis	5.7%
223	Asthma, Aspirin-Induced	5.7%
224	Vertebral Artery Dissection	5.6%
225	Milk Allergy	5.6%
226	Schnitzler Syndrome	5.6%
227	Wheat Hypersensitivity	5.6%
228	Hypergammaglobulinemia	5.5%
229	Agammaglobulinemia	5.4%
230	HIV Infections	5.4%
231	Transfusion-Related Acute Lung Injury	5.4%
232	Subarachnoid Hemorrhage, Traumatic	5.4%
233	Carotid Artery, Internal, Dissection	5.4%
234	Sinus Thrombosis, Intracranial	5.4%
235	Respiratory Hypersensitivity	5.3%
236	Shock, Cardiogenic	5.3%
237	Angina, Unstable	5.2%
238	Sick Building Syndrome	5.1%
239	Multiple Chemical Sensitivity	5.1%
240	Intermittent Claudication	5.1%
241	Pulmonary Embolism	5.1%
242	Aortic Valve Stenosis	5%
243	Cardiomyopathy, Dilated	5%
244	Plasmacytoma	5%
245	Pulmonary Valve Stenosis	5%
246	Tumor Lysis Syndrome	5%
247	Urticaria	5%
248	Ischemic contracture	5%
249	HTLV-I Infections	5%
250	No-Reflow Phenomenon	5%
251	Tricuspid Atresia	5%
252	Arrhythmogenic Right Ventricular Dysplasia	5%
253	Job Syndrome	5%
254	Leukomalacia, Periventricular	5%
255	Myelitis, Transverse	5%
256	Cerebral Arterial Diseases	4.9%
257	Vertebrobasilar Insufficiency	4.9%
258	Anterior Spinal Artery Syndrome	4.9%
259	Basilar Artery Stenosis	4.9%
260	Vertebral Artery Stenosis	4.9%
261	Intracranial Hemorrhage, Hypertensive	4.9%
262	Transient Cerebral Ischemia	4.9%
263	Diabetic Foot	4.9%
264	Carotid Artery Injuries	4.9%
265	Coronary Restenosis	4.9%
266	Cerebral Infarction	4.9%
267	Brain Stem Infarctions	4.9%
268	Infarction, Middle Cerebral Artery	4.8%
269	Infarction, Anterior Cerebral Artery	4.8%
270	Infarction, Posterior Cerebral Artery	4.8%
271	Sezary Syndrome	4.7%
272	Cavernous Sinus Thrombosis	4.6%
273	Sagittal Sinus Thrombosis	4.6%
274	Bacterial Endocarditis	4.6%
275	Miller Fisher Syndrome	4.4%
276	Cardiac Output, High	4.3%
277	Myocardial Stunning	4.3%
278	Low Cardiac Output Syndrome	4.3%
279	Cardiomegaly	4.3%
280	Postpericardiotomy Syndrome	4.3%
281	Cardiac Hypertrophy	4.3%
282	Basal Ganglia Hemorrhage	4.2%
283	Shy-Drager Syndrome	4.2%
284	Purpura, Hyperglobulinemic	4.2%
285	Rheumatic Heart Disease	4.2%
286	Mastocytosis, Systemic	4.1%
287	Lymphoma	4.1%
288	Mastocytosis	4.1%
289	Drug Eruptions	4%
290	Heart Block	4%
291	Tachycardia	4%
292	Lateral Medullary Syndrome	4%
293	Tachyarrhythmia	4%
294	Aortic coarctation	4%
295	Cor Triatriatum	4%
296	Coronary Vessel Anomalies	4%
297	Patent ductus arteriosus	4%
298	Ebstein Anomaly	4%
299	Chronic granulomatous disease	4%
300	Heart Septal Defects	4%
301	Heavy Chain Disease	4%
302	Tetralogy of Fallot	4%
303	Transposition of Great Vessels	4%
304	Hypoplastic Left Heart Syndrome	4%
305	Dermatitis, Allergic Contact	4%
306	HIV Seropositivity	4%
307	Hypertension, Renovascular	3.9%
308	Subarachnoid Hemorrhage	3.9%
309	Hypoxia-Ischemia, Brain	3.9%
310	Cerebral Hemorrhage	3.9%
311	Angina Pectoris, Variant	3.9%
312	Hepatic Vein Thrombosis	3.8%
313	Budd-Chiari Syndrome	3.8%
314	Hypertrophic Cardiomyopathy	3.7%
315	Pulmonary Infarction	3.7%
316	Hypertrophic obstructive cardiomyopathy	3.7%
317	Subclavian Steal Syndrome	3.7%
318	Aortic Valve Insufficiency	3.4%
319	Restrictive cardiomyopathy	3.4%
320	Endocardial Fibroelastosis	3.4%
321	Heart Rupture, Post-Infarction	3.4%
322	Mitral Valve Insufficiency	3.4%
323	Mitral Valve Stenosis	3.4%
324	Myocarditis	3.4%
325	Pericarditis, Constrictive	3.4%
326	Pulmonary Valve Insufficiency	3.4%
327	Tricuspid Valve Insufficiency	3.4%
328	Tricuspid Valve Stenosis	3.4%
329	Ventricular Dysfunction, Left	3.4%
330	Right Ventricular Dysfunction	3.4%
331	Endomyocardial Fibrosis	3.4%
332	Carditis	3.4%
333	Heart Failure, Systolic	3.4%
334	Heart Failure, Diastolic	3.4%
335	Kernicterus	3.4%
336	Pseudoxanthoma Elasticum	3.4%
337	Acquired Immunodeficiency Syndrome	3.3%
338	AIDS related complex	3.3%
339	Dextrocardia	3.3%
340	Infectious Mononucleosis	3.3%
341	Long QT Syndrome	3.3%
342	Pituitary Apoplexy	3.3%
343	POEMS Syndrome	3.3%
344	Hodgkin Disease	3.3%
345	Leukemia, Plasma Cell	3.3%
346	Lymphoma, Non-Hodgkin	3.3%
347	Putaminal Hemorrhage	3.3%
348	Supravalvular aortic stenosis	3.3%
349	Lown-Ganong-Levine Syndrome	3.3%
350	Leukemia, T-Cell	3.3%
351	Acute Generalized Exanthematous Pustulosis	3.3%
352	Leukemia, B-Cell	3.3%
353	Dementia, Vascular	3.3%
354	Asthma, Exercise-Induced	3%
355	Status Asthmaticus	3%
356	Hydrops Fetalis	3%
357	Lymphoma, Follicular	2.9%
358	T-Cell Lymphoma	2.9%
359	Mantle cell lymphoma	2.9%
360	Cerebral Amyloid Angiopathy	2.9%
361	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2.9%
362	Leukemia, Large Granular Lymphocytic	2.9%
363	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2.9%
364	AIDS-Related Opportunistic Infections	2.9%
365	Dermatitis, Atopic	2.9%
366	Asthma	2.8%
367	HIV Wasting Syndrome	2.8%
368	AIDS Dementia Complex	2.8%
369	AIDS-Associated Nephropathy	2.8%
370	Sick Sinus Syndrome	2.8%
371	Composite Lymphoma	2.8%
372	Lymphoma, T-Cell, Cutaneous	2.8%
373	Lymphoma, AIDS-Related	2.8%
374	Enteropathy-Associated T-Cell Lymphoma	2.8%
375	Primary Effusion Lymphoma	2.8%
376	Erythema Nodosum	2.7%
377	Carcinoid Heart Disease	2.7%
378	Dermatitis, Photoallergic	2.7%
379	Lymphangioleiomyomatosis	2.7%
380	Mycosis Fungoides	2.7%
381	Lymphomatoid Papulosis	2.7%
382	Plasmablastic lymphoma	2.7%
383	Adams-Stokes Syndrome	2.6%
384	Atrioventricular Block	2.6%
385	Bundle-Branch Block	2.6%
386	Atrial Premature Complexes	2.6%
387	Sinoatrial Block	2.6%
388	Tachycardia, Paroxysmal	2.6%
389	Supraventricular tachycardia	2.6%
390	Tachycardia, Ventricular	2.6%
391	Wolff-Parkinson-White Syndrome	2.6%
392	Tachycardia, Reciprocating	2.6%
393	Aortopulmonary Septal Defect	2.6%
394	Double Outlet Right Ventricle	2.6%
395	Endocardial Cushion Defects	2.6%
396	Myocardial bridging	2.6%
397	Aorticopulmonary Septal Defect	2.6%
398	Asthma, Occupational	2.6%
399	Sinus Arrhythmia	2.5%
400	Atrial Fibrillation	2.5%
401	Atrial Flutter	2.5%
402	Edema, Cardiac	2.5%
403	Ventricular Fibrillation	2.5%
404	Ventricular Flutter	2.5%
405	Parasystole	2.5%
406	Paroxysmal atrial fibrillation	2.5%
407	Bradycardia	2.5%
408	Diabetic Cardiomyopathies	2.5%
409	Noonan Syndrome	2.5%
410	Farmer's Lung	2.5%
411	Cardiomyopathy, Alcoholic	2.5%
412	Ectopia Cordis	2.5%
413	Sudden Cardiac Death	2.5%
414	Left Ventricular Hypertrophy	2.5%
415	Right Ventricular Hypertrophy	2.5%
416	Single umbilical artery	2.5%
417	Chagas Cardiomyopathy	2.5%
418	Wiskott-Aldrich Syndrome	2.5%
419	Hay fever	2.5%
420	Rhinitis, Allergic, Perennial	2.5%
421	HIV-Associated Lipodystrophy Syndrome	2.5%
422	Aspergillosis, Allergic Bronchopulmonary	2.4%
423	Subacute Bacterial Endocarditis	2.4%
424	Lymphomatoid Granulomatosis	2.3%
425	Marfan Syndrome	2.3%
426	Aortic Valve Prolapse	2.2%
427	Tricuspid Valve Prolapse	2.2%
428	Takotsubo Cardiomyopathy	2.2%
429	Romano-Ward Syndrome	2.2%
430	Toxic Epidermal Necrolysis	2%
431	Stevens-Johnson Syndrome	2%
432	Dyspnea, Paroxysmal	2%
433	Burkitt Lymphoma	2%
434	Tachycardia, Atrioventricular Nodal Reentry	2%
435	Tachycardia, Ectopic Atrial	2%
436	Tachycardia, Ectopic Junctional	2%
437	Sinus Tachycardia	2%
438	Torsades de Pointes	2%
439	Accelerated Idioventricular Rhythm	2%
440	Truncus Arteriosus, Persistent	2%
441	Hematoma, Subdural	1.8%
442	Hematoma, Epidural, Cranial	1.8%
443	MELAS Syndrome	1.8%
444	Dural Arteriovenous Fistula	1.7%
445	Sinus Arrest, Cardiac	1.7%
446	Brain Hemorrhage, Traumatic	1.6%
447	Hematoma, Subdural, Intracranial	1.5%
448	Hematoma, Subdural, Chronic	1.5%
449	Hematoma, Subdural, Acute	1.5%
450	Fabry Disease	1.4%
451	Turner Syndrome	1.3%
452	Kartagener Syndrome	1%
453	Williams Syndrome	0.8%
454	Kearns-Sayre syndrome	0.8%

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