MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Brain Diseases, Metabolic, Inborn

(UMLS:C0752109)

Definition:: Brain disorders resulting from inborn metabolic errors, primarily from enzymatic defects which lead to substrate accumulation, product reduction, or increase in toxic metabolites through alternate pathways. The majority of these conditions are familial, however spontaneous mutation may also occur in utero.
UMLS ID:: C0752109
MeSH ID:: D020739

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.163.100

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.565.189

Classification 3:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.132.100|C18.452.648.189

Synonym(s)

Brain Diseases, Metabolic, Inborn

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	molybdenum cofactor		23595682	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Smith-Lemli-Opitz Syndrome	40.5%
2	Amino Acid Metabolism, Inborn Errors	37.6%
3	Carbohydrate Metabolism, Inborn Errors	37.6%
4	Metal Metabolism, Inborn Errors	37.6%
5	Progeria	37.6%
6	Lysosomal Storage Diseases	37.6%
7	Peroxisomal Disorders	37.6%
8	Pseudohypoparathyroidism	36.3%
9	Myelinolysis, Central Pontine	35.7%
10	Hyperphosphaturia	35.5%
11	Reye Syndrome	33%
12	Hepatic Encephalopathy	32.9%
13	Mitochondrial Encephalomyopathies	32.8%
14	Hyperhomocysteinemia	32.5%
15	Hypolipoproteinemias	32.2%
16	Hyperlipoproteinemia Type IV	31.6%
17	Hyperlipoproteinemia Type V	31.6%
18	Hyperlipidemia, Familial Combined	30.8%
19	Lactose Intolerance	30.7%
20	Mucopolysaccharidosis III	30.6%
21	Hyperlipoproteinemia Type III	30%
22	Familial Hypophosphatemic Rickets	29.8%
23	Amyloid Neuropathies, Familial	29.1%
24	Cytochrome-c Oxidase Deficiency	28.7%
25	Mucopolysaccharidosis II	28.1%
26	Alkaptonuria	27.9%
27	Glycogen Storage Disease	27.9%
28	Hypophosphatasia	27.9%
29	Propionic acidemia	27.9%
30	Dihydropyrimidine Dehydrogenase Deficiency	27.9%
31	Cystinosis	27.9%
32	Neuronal Ceroid-Lipofuscinoses	27.5%
33	Wasting Syndrome	27.1%
34	Wernicke Encephalopathy	27.1%
35	Glycogen storage disease type II	26.8%
36	Hypoalphalipoproteinemias	26.7%
37	Hypercalcemia	26.5%
38	Hypocalcemia	26.5%
39	Milk-Alkali Syndrome	26.5%
40	Gaucher Disease	25.8%
41	Fabry Disease	25.5%
42	Leigh Disease	25%
43	Renal tubular acidosis	25%
44	Kernicterus	24.7%
45	Acid-Base Imbalance	24.2%
46	Calcium Metabolism Disorders	24.2%
47	Iron Metabolism Disorders	24.2%
48	Phosphorus Metabolism Disorders	24.2%
49	Water-Electrolyte Imbalance	24.2%
50	Lipid Metabolism Disorders	24.2%
51	Mitochondrial Diseases	24.2%
52	Glucose Metabolism Disorders	24.2%
53	Carbamoyl-Phosphate Synthase I Deficiency Disease	24%
54	Werner Syndrome	23.5%
55	Hepatolenticular Degeneration	23.4%
56	Tay-Sachs Disease	23.3%
57	Glycogen Storage Disease Type I	23.1%
58	Glycogen Storage Disease Type V	23.1%
59	Lipodystrophy	22.7%
60	Albinism	22.6%
61	Galactosemias	22.4%
62	Urea Cycle Disorders, Inborn	22.4%
63	Tyrosinemias	22.4%
64	Niemann-Pick Disease, Type C	22.4%
65	Familial Periodic Paralysis	22.4%
66	Rickets	21.6%
67	Renal Aminoacidurias	20.8%
68	Fanconi Syndrome	20.8%
69	Pseudohypoaldosteronism	20.8%
70	Liddle Syndrome	20.8%
71	Ichthyosis, X-Linked	20.7%
72	Menkes Kinky Hair Syndrome	20.5%
73	Glycosuria, Renal	20.4%
74	Osteopenia	20.3%
75	Sjogren-Larsson Syndrome	20%
76	Antley-Bixler Syndrome Phenotype	19.6%
77	Marchiafava-Bignami Disease	19.4%
78	Refsum Disease	18.9%
79	Adrenoleukodystrophy	18.9%
80	Gout	18.8%
81	Friedreich Ataxia	18.7%
82	Cockayne Syndrome	18.2%
83	Hypokalemic periodic paralysis	18.2%
84	Homocystinuria	18%
85	Congenital Hyperinsulinism	17.6%
86	Ataxia Telangiectasia	17.4%
87	Cystinuria	17.2%
88	Zellweger Syndrome	17.1%
89	Osteomalacia	16.4%
90	Acidosis	15.9%
91	Alkalosis	15.9%
92	Amyloidosis	15.9%
93	Calcinosis	15.9%
94	Hyperglycemia	15.9%
95	Hyperinsulinism	15.9%
96	Hyperkalemia	15.9%
97	Hypernatremia	15.9%
98	Hypoglycemia	15.9%
99	Hypokalemia	15.9%
100	Hyponatremia	15.9%
101	Xanthomatosis	15.9%
102	Hypophosphatemia	15.9%
103	Metabolic acidosis	15.9%
104	Dyslipidemias	15.9%
105	Iron Overload	15.9%
106	Xanthoma	15.9%
107	Meningoencephalitis	15.6%
108	Bloom Syndrome	15.5%
109	Diabetic Ketoacidosis	15.5%
110	Arthritis, Gouty	15.4%
111	Dandy-Walker Syndrome	15.4%
112	Porphyrias, Hepatic	15.1%
113	Dementia, Vascular	15%
114	Subdural Effusion	14.8%
115	Fanconi Anemia	14.8%
116	Dystonia Musculorum Deformans	14.4%
117	Huntington Disease	14.2%
118	Nesidioblastosis	13.9%
119	Akinetic Mutism	13.9%
120	Anoxic Encephalopathy	13.9%
121	Basal Ganglia Diseases	13.9%
122	Brain Damage, Chronic	13.9%
123	Cerebellar Diseases	13.9%
124	Encephalitis	13.9%
125	Encephalomalacia	13.9%
126	Epilepsy	13.9%
127	Hydrocephalus	13.9%
128	Congenital Hydrocephalus	13.9%
129	Hypothalamic Diseases	13.9%
130	Thalamic Diseases	13.9%
131	Intracranial Hypertension	13.9%
132	Aura	13.9%
133	Leukoencephalopathy	13.9%
134	Neuroaxonal Dystrophies	13.9%
135	Headache Disorders	13.9%
136	Intracranial Hypotension	13.9%
137	Brain Edema	13.9%
138	Brain Hypoxia	13.9%
139	Aqueductal Stenosis	13.9%
140	Nutrition Disorders	13.8%
141	Diabetes Mellitus	13.7%
142	Optic Atrophy, Hereditary, Leber	13.5%
143	Dehydration	13.4%
144	Encephalomyelitis	13.4%
145	Lipomatosis	13.4%
146	Water Intoxication	13.4%
147	Posterior Leukoencephalopathy Syndrome	13.4%
148	Posterior reversible encephalopathy syndrome	13.4%
149	Achlorhydria	13.3%
150	Osteoporosis	13.3%
151	Bone Demineralization, Pathologic	13.3%
152	Post-Traumatic Osteoporosis	13.3%
153	Amyotrophic Lateral Sclerosis	13.2%
154	Celiac Disease	13.2%
155	Sprue, Tropical	13.2%
156	Steatorrhea	13.2%
157	Sprue	13.2%
158	Leukomalacia, Periventricular	13.2%
159	Basal Ganglia Cerebrovascular Disease	13.1%
160	Lewy Body Disease	13%
161	Mitochondrial Myopathies	12.9%
162	Multiple System Atrophy	12.9%
163	Pneumocephalus	12.8%
164	Parkinsonian Disorders	12.6%
165	Lafora Disease	12.6%
166	Unverricht-Lundborg Syndrome	12.6%
167	Brain Abscess	12.5%
168	Cerebral Amyloid Angiopathy	12.4%
169	Epilepsy, Post-Traumatic	12.2%
170	Aicardi's syndrome	12.1%
171	Renal Osteodystrophy	11.9%
172	Renal rickets	11.9%
173	Acidosis, Lactic	11.8%
174	Calciphylaxis	11.8%
175	Hemosiderosis	11.8%
176	Ketosis	11.8%
177	Ketonuria	11.8%
178	Ketoacidosis	11.8%
179	Ketonemia	11.8%
180	Vascular calcification	11.8%
181	Canavan Disease	11.8%
182	Alexander Disease	11.8%
183	HIV-Associated Lipodystrophy Syndrome	11.7%
184	Cerebrovascular Disorders	11.7%
185	Cerebrovascular Insufficiency	11.7%
186	Dementia	11.7%
187	Myasthenic Syndromes, Congenital	11.7%
188	HIV Wasting Syndrome	11.7%
189	Vascular Headaches	11.5%
190	Hypoxia-Ischemia, Brain	11.4%
191	Myoclonic Epilepsy	11.4%
192	Epilepsy, Temporal Lobe	11.4%
193	Epilepsy, Rolandic	11.4%
194	Benign Rolandic Epilepsy	11.4%
195	Fragile X Syndrome	11.4%
196	Brain Injuries	11.4%
197	Brain Neoplasms	11.3%
198	Glycosuria	11.3%
199	MELAS Syndrome	11.2%
200	Frontotemporal dementia	11.2%
201	Xeroderma Pigmentosum	11.1%
202	Variegate Porphyria	11.1%
203	Acute intermittent porphyria	11.1%
204	Porphyria Cutanea Tarda	11.1%
205	Meige Syndrome	10.9%
206	Cerebral Ventriculitis	10.9%
207	Alstrom Syndrome	10.7%
208	Cerebellar Neoplasms	10.5%
209	CHARGE Syndrome	10.5%
210	Muscular Dystrophy, Duchenne	10.5%
211	Smith-Magenis syndrome	10.5%
212	Brain Death	10.5%
213	Neoplastic Syndromes, Hereditary	10.4%
214	Cystic Fibrosis	10.3%
215	Prader-Willi Syndrome	10.3%
216	Parkinson Disease	10.2%
217	Meningitis	10.1%
218	Movement Disorders	10.1%
219	Pachymeningitis	10.1%
220	Spinal Cord Diseases	10.1%
221	Kearns-Sayre syndrome	10.1%
222	Brain Diseases, Metabolic	10.1%
223	Multiple Epiphyseal Dysplasia	10.1%
224	Osteochondrodysplasias	10.1%
225	Pelger-Huet Anomaly	10.1%
226	Ocular Motility Disorders	10%
227	Cyclophoria	10%
228	Myelitis	9.9%
229	Necrobiosis Lipoidica Diabeticorum	9.9%
230	Brain Diseases, Metabolic, Inborn	9.9%
231	Anemia, Sickle Cell	9.9%
232	Thalassemia	9.9%
233	Acidosis, Respiratory	9.9%
234	Adiposis Dolorosa	9.9%
235	Alkalosis, Respiratory	9.9%
236	Epidural Abscess	9.9%
237	Tetany	9.9%
238	Hypercholesterolemia	9.8%
239	Hyperlipoproteinemias	9.8%
240	Hypertriglyceridemia	9.8%
241	Insulin Resistance	9.8%
242	Osteoporosis, Postmenopausal	9.8%
243	Basal Ganglia Hemorrhage	9.6%
244	Amblyopia	9.5%
245	Muscular Dystrophy	9.5%
246	Juvenile Myoclonic Epilepsy	9.5%
247	Myoclonic Epilepsies, Progressive	9.5%
248	Beckwith-Wiedemann Syndrome	9.5%
249	Wolf-Hirschhorn Syndrome	9.5%
250	Tuberous Sclerosis	9.5%
251	Leukoencephalopathy, Progressive Multifocal	9.4%
252	Creutzfeldt-Jakob disease	9.4%
253	Nail-Patella Syndrome	9.3%
254	Cerebral Palsy	9.2%
255	Epilepsies, Partial	9.2%
256	Epilepsy, Generalized	9.2%
257	Pseudotumor Cerebri	9.2%
258	Hypertensive Encephalopathy	9.2%
259	Simple Partial Seizures	9.2%
260	Epilepsy, Reflex	9.2%
261	Headache Disorders, Primary	9.2%
262	Headache Disorders, Secondary	9.2%
263	Medication overuse headache	9.2%
264	Myotonic Dystrophy	9.1%
265	Cri-du-Chat Syndrome	9.1%
266	Down Syndrome	9.1%
267	Rett Syndrome	9.1%
268	Trisomy 21	9.1%
269	Neuroleptic Malignant Syndrome	9%
270	Progressive supranuclear palsy	8.9%
271	Dwarfism	8.9%
272	Lupus Vasculitis, Central Nervous System	8.8%
273	Striatonigral Degeneration	8.8%
274	Holoprosencephaly	8.7%
275	Central Nervous System Infection	8.7%
276	Gestational Diabetes	8.7%
277	Latent Autoimmune Diabetes in Adults	8.7%
278	Subacute Combined Degeneration	8.6%
279	Pituitary Apoplexy	8.6%
280	Diabetes Mellitus, Experimental	8.6%
281	Osteogenesis Imperfecta	8.6%
282	Brain Infarction	8.5%
283	Pituitary Adenoma	8.5%
284	Pituitary Neoplasms	8.5%
285	Nephrocalcinosis	8.5%
286	Limbic Encephalitis	8.4%
287	Amnesia, Transient Global	8.2%
288	Putaminal Hemorrhage	8.1%
289	Kartagener Syndrome	8.1%
290	Child Nutrition Disorders	8.1%
291	Hypervitaminosis A	8.1%
292	Infant Nutrition Disorders	8.1%
293	Malnutrition	8.1%
294	Presenile dementia	8%
295	Senile dementia	8%
296	Stiff-Person Syndrome	8%
297	Pituitary Diseases	8%
298	Familial Mediterranean Fever	7.9%
299	Leukoencephalitis, Acute Hemorrhagic	7.9%
300	Wiskott-Aldrich Syndrome	7.9%
301	Brain Hemorrhage, Traumatic	7.9%
302	Infarction, Middle Cerebral Artery	7.9%
303	Infarction, Anterior Cerebral Artery	7.9%
304	Infarction, Posterior Cerebral Artery	7.9%
305	Carotid Artery Injuries	7.8%
306	Shy-Drager Syndrome	7.8%
307	Prion Diseases	7.8%
308	Carotid Artery Diseases	7.7%
309	Brain Ischemia	7.7%
310	Cerebrovascular accident	7.7%
311	Kluver-Bucy Syndrome	7.7%
312	Vasospasm, Intracranial	7.7%
313	Intracranial Arterial Diseases	7.7%
314	Marfan Syndrome	7.6%
315	Autoimmune Lymphoproliferative Syndrome	7.6%
316	MPTP Poisoning	7.5%
317	Rubinstein-Taybi Syndrome	7.5%
318	Brain Injuries, Diffuse	7.5%
319	Traumatic Brain Injury	7.5%
320	Cerebellar Ataxia	7.5%
321	Supratentorial Neoplasms	7.5%
322	Angioedemas, Hereditary	7.4%
323	Primary amyloidosis	7.4%
324	Williams Syndrome	7.4%
325	Ectodermal Dysplasia	7.4%
326	Aplasia Cutis Congenita	7.4%
327	Sickle Cell Trait	7.3%
328	Toxoplasmosis, Cerebral	7.3%
329	Persistent Vegetative State	7.2%
330	Spinal Muscular Atrophy	7.1%
331	Progressive Muscular Atrophy	7.1%
332	Meningitis, Bacterial	7.1%
333	Meningitis, Fungal	7.1%
334	Cerebral Infarction	7.1%
335	Brain Stem Infarctions	7.1%
336	Vasculitis, Central Nervous System	7%
337	Myotonia Congenita	7%
338	Poliomyelitis	7%
339	Paraneoplastic Cerebellar Degeneration	7%
340	Moyamoya Disease	7%
341	Spinal Cord Injuries	6.9%
342	Deformity	6.9%
343	Post-Traumatic Headache	6.9%
344	Tension Headache	6.9%
345	Epilepsy, Complex Partial	6.9%
346	Migraine Disorders	6.9%
347	Abdominal Migraine	6.9%
348	Status Migrainosus	6.9%
349	Cervicogenic Headache	6.9%
350	Ophthalmoplegic Migraine	6.8%
351	Encephalomyelitis, Acute Disseminated	6.8%
352	Kallmann Syndrome	6.7%
353	Charcot-Marie-Tooth Disease	6.7%
354	Asterixis	6.7%
355	Ballismus	6.7%
356	Miller Fisher Syndrome	6.6%
357	Intracranial Embolism and Thrombosis	6.6%
358	Polycystic Kidney Diseases	6.6%
359	Primary Ciliary Dyskinesia	6.5%
360	Lateral Medullary Syndrome	6.3%
361	Duane Retraction Syndrome	6.3%
362	Welander Distal Myopathy	6.3%
363	Classical Lissencephalies and Subcortical Band Heterotopias	6.2%
364	Cranial nerve diseases	6.2%
365	Demyelinating Diseases	6.2%
366	Demyelination	6.2%
367	Neuromuscular Diseases	6.2%
368	Chronobiology Disorders	6.2%
369	Chronic Fatigue Syndrome	6.1%
370	Retinal Dysplasia	6%
371	Aniridia	6%
372	Acute Chest Syndrome	6%
373	Arachnoiditis	6%
374	Aseptic Meningitis	6%
375	Syringomyelia	6%
376	Essential Tremor	6%
377	Familial Tremor	6%
378	Pneumorrhachis	6%
379	Writer's Cramp	6%
380	Epidermolysis Bullosa	5.9%
381	CREST Syndrome	5.9%
382	Empty Sella Syndrome	5.8%
383	Hyperpituitarism	5.8%
384	Hypopituitarism	5.8%
385	Hypophysitis	5.8%
386	Fetal Diseases	5.8%
387	Myelitis, Transverse	5.8%
388	Cutis Laxa	5.7%
389	Cluster Headache	5.7%
390	Migraine with Aura	5.7%
391	Familial Hemiplegic Migraine	5.7%
392	Chronic Paroxysmal Hemicrania	5.7%
393	SUNCT Syndrome	5.7%
394	Paroxysmal Hemicrania	5.7%
395	Subarachnoid Hemorrhage, Traumatic	5.7%
396	Carotid Artery, Internal, Dissection	5.7%
397	Cerebral Arterial Diseases	5.7%
398	Vertebrobasilar Insufficiency	5.7%
399	Basilar Artery Stenosis	5.7%
400	Vertebral Artery Stenosis	5.7%
401	Intracranial Hemorrhage, Hypertensive	5.7%
402	Transient Cerebral Ischemia	5.7%
403	Retinitis Pigmentosa	5.7%
404	Pigmentary retinopathy	5.7%
405	Porokeratosis	5.7%
406	Keratoderma, Palmoplantar	5.7%
407	Chronic granulomatous disease	5.7%
408	Spinal Cord Neoplasms	5.7%
409	Motor Neuron Disease	5.6%
410	Diffuse Axonal Injury	5.6%
411	Brain Stem Neoplasms	5.6%
412	Mobius Syndrome	5.4%
413	Tuberculosis, Meningeal	5.4%
414	Trauma, Nervous System	5.3%
415	Subacute Sclerosing Panencephalitis	5.3%
416	Deficiency Diseases	5.3%
417	Starvation	5.3%
418	Refeeding Syndrome	5.3%
419	Restless Legs Syndrome	5.2%
420	Auditory Perceptual Disorders	5.2%
421	Akathisia, Drug-Induced	5.2%
422	Nervous System Neoplasms	5.2%
423	Neurologic Manifestations	5.2%
424	Neurotoxicity Syndromes	5.2%
425	Opsoclonus-Myoclonus Syndrome	5.1%
426	AIDS Dementia Complex	5.1%
427	Polyradiculoneuropathy	5%
428	Polyradiculoneuritis	5%
429	Hydranencephaly	5%
430	Neural Tube Defects	5%
431	Tethered Cord Syndrome	5%
432	Iniencephaly	5%
433	Craniorachischisis	5%
434	Exencephaly	5%
435	Septo-Optic Dysplasia	5%
436	Cortical Dysplasia	5%
437	Central Nervous System Fungal Infections	5%
438	Conus Medullaris Syndrome	5%
439	Spinal Cord Vascular Diseases	5%
440	Malformations of Cortical Development	5%
441	Central Nervous System Cysts	5%
442	Dural Arteriovenous Fistula	5%
443	Toxoplasmosis, Congenital	5%
444	Peutz-Jeghers Syndrome	5%
445	Thrombasthenia	5%
446	Antithrombin III Deficiency	5%
447	Protein C Deficiency	5%
448	Afibrinogenemia	4.9%
449	Factor VII Deficiency	4.9%
450	Factor X Deficiency	4.9%
451	Factor XII Deficiency	4.9%
452	Hemophilia A	4.9%
453	Activated Protein C Resistance	4.9%
454	Factor II deficiency	4.9%
455	Factor VIII Deficiency	4.9%
456	Factor V deficiency	4.9%
457	Factor XI Deficiency	4.9%
458	Hypoprothrombinemias	4.9%
459	Carotid Stenosis	4.9%
460	Intracranial Aneurysm	4.9%
461	Vertebral Artery Dissection	4.9%
462	Anemia, Diamond-Blackfan	4.9%
463	Intracranial Arteriosclerosis	4.9%
464	Cerebral Atherosclerosis	4.9%
465	Subarachnoid Hemorrhage	4.9%
466	Cerebral Arteriosclerosis	4.9%
467	Cerebral Hemorrhage	4.9%
468	Brain Contusion	4.9%
469	Cerebral Thrombosis	4.9%
470	Intracranial Embolism	4.9%
471	Intracranial Thrombosis	4.9%
472	Polycystic Kidney, Autosomal Dominant	4.9%
473	Pseudoxanthoma Elasticum	4.8%
474	Hyperprolactinemia	4.8%
475	Subclavian Steal Syndrome	4.7%
476	Pick Disease of the Brain	4.7%
477	Anencephaly	4.7%
478	Hyperkeratosis, Epidermolytic	4.7%
479	Dyskinesia, Drug-Induced	4.7%
480	Choroid Plexus Papilloma	4.6%
481	Brain Concussion	4.6%
482	Meconium Aspiration Syndrome	4.5%
483	Multiple Endocrine Neoplasia	4.5%
484	Sleep Wake Disorders	4.5%
485	Autonomic Dysreflexia	4.5%
486	Complex Regional Pain Syndromes	4.5%
487	Congenital Hypothyroidism	4.4%
488	Dermatitis, Atopic	4.4%
489	Central Nervous System Bacterial Infections	4.3%
490	Meningitis, Cryptococcal	4.3%
491	Scrapie	4.3%
492	Central Cord Syndrome	4.3%
493	Meningitis, Listeria	4.3%
494	Carotid Artery Thrombosis	4.3%
495	Meningitis, Haemophilus	4.3%
496	Meningitis, Pneumococcal	4.3%
497	Chorea	4.2%
498	Papillon-Lefevre Disease	4.2%
499	Xeroderma	4.2%
500	West Nile Fever	4.2%
501	Alice in Wonderland Syndrome	4.1%
502	Acromegaly	4.1%
503	Sinus Thrombosis, Intracranial	4.1%
504	Basal Cell Nevus Syndrome	4%
505	Abdominal Cramps	4%
506	Abnormalities, Drug-Induced	4%
507	Amniotic Band Syndrome	4%
508	Asphyxia Neonatorum	4%
509	Infant, Premature, Diseases	4%
510	Situs Inversus	4%
511	Infantile Colic	4%
512	Giant Cell Arteritis	4%
513	Temporal Arteritis	4%
514	Behcet Syndrome	4%
515	Kwashiorkor	3.9%
516	Magnesium Deficiency	3.9%
517	Potassium Deficiency	3.9%
518	Protein Deficiency	3.9%
519	Avitaminosis	3.9%
520	Peripheral Nerve Injuries	3.9%
521	Guillain-Barre Syndrome	3.8%
522	Myasthenia Gravis	3.8%
523	Congenital nystagmus	3.8%
524	Torticollis	3.7%
525	Klinefelter Syndrome	3.7%
526	Lambert-Eaton Myasthenic Syndrome	3.7%
527	Cavernous Sinus Thrombosis	3.6%
528	Sagittal Sinus Thrombosis	3.6%
529	Hematoma, Subdural	3.5%
530	Hematoma, Epidural, Cranial	3.5%
531	Eye Abnormalities	3.5%
532	Cardiovascular Abnormalities	3.5%
533	Hydrops Fetalis	3.5%
534	Sleep Disorders, Circadian Rhythm	3.4%
535	Turner Syndrome	3.4%
536	Skin Abnormalities	3.4%
537	Lymphatic Abnormalities	3.4%
538	Congenital Microtia	3.4%
539	Dysautonomia	3.4%
540	Vagus Nerve Disorder	3.4%
541	Glossopharyngeal Neuralgia	3.4%
542	Abducens Nerve Diseases	3.4%
543	Heavy Metal Poisoning, Nervous System	3.4%
544	Neuromuscular Junction Diseases	3.4%
545	Tauopathies	3.4%
546	Trochlear Nerve Diseases	3.4%
547	Peripheral Nervous System Diseases	3.4%
548	Anemia, Neonatal	3.4%
549	Persistent Fetal Circulation Syndrome	3.4%
550	Botulism	3.3%
551	Congenital diaphragmatic hernia	3.3%
552	Umbilical hernia	3.3%
553	Progressive bulbar palsy	3.3%
554	Bulbar palsy	3.3%
555	Multiple Endocrine Neoplasia Type 1	3.3%
556	Meningomyelocele	3.3%
557	Spina Bifida	3.3%
558	Spinal Cord Ischemia	3.3%
559	Olfactory Nerve Injuries	3.3%
560	Causalgia	3.3%
561	Nephroblastoma	3.3%
562	Ascorbic Acid Deficiency	3.3%
563	Vitamin A Deficiency	3.3%
564	Vitamin D Deficiency	3.3%
565	Vitamin E Deficiency	3.3%
566	Marasmus	3.3%
567	Neuromyelitis Optica	3.3%
568	Tuberculosis, Central Nervous System	3.3%
569	Obesity	3.3%
570	Nelson Syndrome	3.2%
571	Prolactinoma	3.2%
572	Growth Hormone-Secreting Pituitary Adenoma	3.2%
573	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	3.1%
574	Microcephaly	3.1%
575	Macrocephaly	3.1%
576	Tardive Dyskinesia	3%
577	Hematoma, Subdural, Intracranial	3%
578	Hematoma, Subdural, Chronic	3%
579	Hematoma, Subdural, Acute	3%
580	Adenomatous Polyposis Coli	3%
581	Urogenital Abnormalities	3%
582	Folic Acid Deficiency	2.9%
583	Pellagra	2.9%
584	Thiamine Deficiency	2.9%
585	Vitamin B 12 Deficiency	2.9%
586	Vitamin B 6 Deficiency	2.9%
587	Pyridoxine Deficiency	2.9%
588	Facial Nerve Injuries	2.9%
589	Neonatal Abstinence Syndrome	2.9%
590	Maxillofacial Abnormalities	2.9%
591	Horner Syndrome	2.9%
592	Dextrocardia	2.9%
593	Myopathy	2.9%
594	Optic Neuropathy	2.9%
595	Fetal Growth Retardation	2.9%
596	Fetal Hypoxia	2.9%
597	Fetal Alcohol Spectrum Disorders	2.9%
598	Porencephaly	2.8%
599	Meningocele	2.8%
600	Multiple Sclerosis	2.8%
601	Syphilis, Congenital	2.8%
602	Neuroaspergillosis	2.8%
603	Encephalocele	2.8%
604	Facial Nerve Diseases	2.8%
605	Craniocerebral Trauma	2.8%
606	Parasomnia	2.8%
607	Dyssomnias	2.8%
608	Vestibulocochlear Nerve Diseases	2.8%
609	Decerebrate State	2.8%
610	Hemiparesis	2.8%
611	Meningism	2.8%
612	Paresis	2.8%
613	Seizures	2.8%
614	Sensation Disorders	2.8%
615	Central Nervous System Neoplasms	2.8%
616	Complex partial seizures	2.8%
617	Monoparesis	2.8%
618	Neurogenic Inflammation	2.8%
619	Gait Disorders, Neurologic	2.8%
620	Neuromuscular Manifestations	2.8%
621	Beriberi	2.8%
622	Obesity, Abdominal	2.8%
623	Sweating, Gustatory	2.8%
624	Auriculotemporal Syndrome	2.8%
625	Reflex Sympathetic Dystrophy	2.7%
626	Nocturnal Myoclonus Syndrome	2.7%
627	Prune Belly Syndrome	2.6%
628	Twins, Conjoined	2.6%
629	Waardenburg Syndrome	2.6%
630	Myasthenia Gravis, Autoimmune, Experimental	2.6%
631	Jet Lag Syndrome	2.6%
632	Pseudorabies	2.6%
633	Chorioamnionitis	2.5%
634	Ophthalmoplegia	2.5%
635	External Ophthalmoplegia	2.5%
636	POEMS Syndrome	2.5%
637	Pupil Disorders	2.5%
638	Neurobehavioral Manifestations	2.5%
639	Dermal Sinus	2.5%
640	Spina Bifida Cystica	2.5%
641	Spina Bifida Occulta	2.5%
642	Anterior Spinal Artery Syndrome	2.5%
643	Lissencephaly	2.5%
644	Polymicrogyria	2.5%
645	Pachygyria	2.5%
646	Schizencephaly	2.5%
647	Periventricular Nodular Heterotopia	2.5%
648	Neurosyphilis	2.4%
649	Pediatric Obesity	2.4%
650	Paraneoplastic Encephalomyelitis	2.4%
651	Uveomeningoencephalitic Syndrome	2.4%
652	Sturge-Weber Syndrome	2.4%
653	Vertigo	2.4%
654	Alcohol-Induced Disorders, Nervous System	2.4%
655	Scimitar Syndrome	2.4%
656	Vitamin K Deficiency	2.4%
657	Acrodynia	2.3%
658	Denys-Drash Syndrome	2.3%
659	Anemia, Pernicious	2.3%
660	Acrocephalosyndactylia	2.3%
661	Vocal Cord Paralysis	2.2%
662	Anophthalmos	2.2%
663	Anus, Imperforate	2.2%
664	Microphthalmos	2.2%
665	Paralysis, Obstetric	2.2%
666	Retinopathy of Prematurity	2.2%
667	Limb Deformities, Congenital	2.2%
668	Craniofacial Abnormalities	2.2%
669	Anorectal Malformations	2.2%
670	Abnormalities, Radiation-Induced	2.2%
671	Bronchopulmonary Dysplasia	2.2%
672	Craniosynostosis	2.2%
673	Syndactyly	2.2%
674	Brachycephaly	2.2%
675	Brachial Plexus Neuritis	2.2%
676	Neuralgic Amyotrophy	2.2%
677	Lyme Neuroborreliosis	2.2%
678	Voice Disorders	2.1%
679	Voice Disturbance	2.1%
680	Malaria, Cerebral	2.1%
681	Scurvy	2.1%
682	Neurocysticercosis	2.1%
683	Waterhouse-Friderichsen Syndrome	2.1%
684	Cerebrospinal Fluid Otorrhea	2%
685	Cerebrospinal Fluid Rhinorrhea	2%
686	Neuritis, Autoimmune, Experimental	2%
687	Gait Ataxia	2%
688	Coma, Post-Head Injury	2%
689	Noonan Syndrome	2%
690	Neuritis	2%
691	Polyneuritis	2%
692	Radiculitis	2%
693	Polyneuropathy	2%
694	Mononeuritis	2%
695	Mononeuropathies	2%
696	Brachial Plexus Neuropathies	2%
697	Radiculopathy	2%
698	Mononeuropathy Multiplex	2%
699	Nerve Root Compression	2%
700	Alcohol Withdrawal Seizures	2%
701	Ophthalmia Neonatorum	2%
702	Cleft Palate	1.9%
703	Blepharophimosis	1.9%
704	Laryngostenosis	1.9%
705	Mouth Abnormalities	1.9%
706	Respiratory Distress Syndrome, Newborn	1.9%
707	Esophageal Atresia	1.9%
708	Intestinal Atresia	1.9%
709	Horseshoe Kidney	1.9%
710	Pectus excavatum	1.9%
711	Tarsal Tunnel Syndrome	1.9%
712	Cauda Equina Syndrome	1.9%
713	Klippel-Feil Syndrome	1.9%
714	Gastroschisis	1.9%
715	Synostosis	1.9%
716	Acrodermatitis	1.9%
717	Lymphangiectasis, Intestinal	1.9%
718	Gianotti-Crosti Syndrome	1.9%
719	Multiple Sclerosis, Chronic Progressive	1.9%
720	Multiple Sclerosis, Relapsing-Remitting	1.9%
721	Reflex, Abnormal	1.8%
722	Hyporeflexia	1.8%
723	Hyperreflexia	1.8%
724	Jaw Abnormalities	1.8%
725	Akathisia	1.8%
726	Restlessness	1.8%
727	Psychomotor Agitation	1.8%
728	Poland Syndrome	1.8%
729	Optic Nerve Glioma	1.7%
730	Arthrogryposis	1.7%
731	Choanal Atresia	1.7%
732	Tracheobronchomegaly	1.7%
733	Laryngocele	1.7%
734	Choledochal Cyst	1.7%
735	Hermaphroditism	1.7%
736	Disorders of Sex Development	1.7%
737	Myositis	1.7%
738	Optic Atrophy	1.7%
739	Optic Neuritis	1.7%
740	Papilledema	1.7%
741	Strabismus	1.7%
742	Tolosa-Hunt Syndrome	1.7%
743	Isaacs syndrome	1.7%
744	Arsenic Poisoning	1.7%
745	Myotonic Disorders	1.7%
746	Cryptorchidism	1.7%
747	Hypospadias	1.7%
748	Diabetic Neuropathies	1.7%
749	Facial Injuries	1.7%
750	Facial Neuralgia	1.7%
751	Diabetic Amyotrophy	1.7%
752	Diabetic Autonomic Neuropathy	1.7%
753	Sleep Talking	1.7%
754	Manganese Poisoning	1.7%
755	Sleep Disorders, Intrinsic	1.7%
756	Orthostatic intolerance	1.7%
757	Amelia	1.6%
758	Anosmia	1.6%
759	Arachnodactyly	1.6%
760	Ataxia	1.6%
761	Athetosis	1.6%
762	Catalepsy	1.6%
763	Dystonia	1.6%
764	Ectopia Cordis	1.6%
765	Ectromelia	1.6%
766	Hemimelia	1.6%
767	Hemiplegia	1.6%
768	Locked-In Syndrome	1.6%
769	Meningeal Neoplasms	1.6%
770	Muscle Hypertonia	1.6%
771	Muscle hypotonia	1.6%
772	Myoclonus	1.6%
773	Myotonia	1.6%
774	Neuralgia	1.6%
775	Paraplegia	1.6%
776	Phocomelia	1.6%
777	Pseudobulbar Palsy	1.6%
778	Quadriplegia	1.6%
779	Sirenomelia	1.6%
780	Spasm	1.6%
781	Spastic Paraplegia	1.6%
782	Status Epilepticus	1.6%
783	Taste Disorders	1.6%
784	Tremor	1.6%
785	Monoplegia	1.6%
786	Hypokinesia	1.6%
787	Polydactyly	1.6%
788	Paraparesis	1.6%
789	Brachydactyly	1.6%
790	Bradykinesia	1.6%
791	Waxy flexibility	1.6%
792	Action Tremor	1.6%
793	Resting Tremor	1.6%
794	Dysosmia	1.6%
795	Plagiocephaly	1.6%
796	Quadriparesis	1.6%
797	Lower Extremity Deformities, Congenital	1.6%
798	Mercury Poisoning, Nervous System	1.6%
799	Olfaction Disorders	1.6%
800	Myokymia	1.6%
801	Upper Extremity Deformities, Congenital	1.6%
802	Lead Poisoning, Nervous System	1.6%
803	Vestibular Neuronitis	1.6%
804	Somatosensory Disorders	1.6%
805	Single umbilical artery	1.6%
806	Neuropathic pain	1.6%
807	Hyperkinesia	1.6%
808	Intention tremor	1.6%
809	Carpal Tunnel Syndrome	1.6%
810	neurofibroma	1.6%
811	Gait Apraxia	1.6%
812	Sciatica	1.6%
813	Micrognathism	1.5%
814	Pierre Robin Syndrome	1.5%
815	Laryngomalacia	1.5%
816	Acoustic Neuroma	1.5%
817	Pectus carinatum	1.5%
818	Bladder Exstrophy	1.5%
819	Epispadias	1.5%
820	Hand-Arm Vibration Syndrome	1.5%
821	Multicystic Dysplastic Kidney	1.5%
822	Vision Disorders	1.5%
823	Metamorphopsia	1.5%
824	Visual Impairment	1.5%
825	Fibromyalgia	1.4%
826	Optic Neuropathy, Ischemic	1.4%
827	Anterior Ischemic Optic Neuropathy	1.4%
828	Medial Tibial Stress Syndrome	1.4%
829	Facial Hemiatrophy	1.4%
830	Melkersson-Rosenthal Syndrome	1.4%
831	Anisocoria	1.4%
832	Confusion	1.4%
833	Facial paralysis	1.4%
834	Lethargy	1.4%
835	Memory Disorders	1.4%
836	Muscle Cramp	1.4%
837	Perceptual Disorders	1.4%
838	Psychomotor Disorders	1.4%
839	Tonic Pupil	1.4%
840	Eosinophilia-Myalgia Syndrome	1.4%
841	Anhedonia	1.4%
842	Disorientation	1.4%
843	Facial Paresis	1.4%
844	Memory Loss	1.4%
845	Hemisensory Neglect	1.4%
846	Dysacusis	1.4%
847	Sleep Bruxism	1.4%
848	Aortic coarctation	1.4%
849	Cor Triatriatum	1.4%
850	Coronary Vessel Anomalies	1.4%
851	Dental Enamel Hypoplasia	1.4%
852	Patent ductus arteriosus	1.4%
853	Ebstein Anomaly	1.4%
854	Heart Septal Defects	1.4%
855	Hyaline Membrane Disease	1.4%
856	Hypodontia	1.4%
857	Macrostomia	1.4%
858	Microstomia	1.4%
859	Muscular Atrophy	1.4%
860	Respiratory Paralysis	1.4%
861	Tetralogy of Fallot	1.4%
862	Transposition of Great Vessels	1.4%
863	Hypoplastic Left Heart Syndrome	1.4%
864	May-Thurner Syndrome	1.4%
865	Retrognathia	1.4%
866	Craniofacial Dysostosis	1.4%
867	Wolff-Parkinson-White Syndrome	1.4%
868	Cubital Tunnel Syndrome	1.4%
869	Hyperandrogenism	1.3%
870	Sciatic Neuropathy	1.3%
871	Ulnar Neuropathies	1.3%
872	Lesion of Sciatic Nerve	1.3%
873	Ulnar Neuritis	1.3%
874	Radial nerve compression	1.3%
875	Radial Tunnel Syndrome	1.3%
876	Peroneal Neuropathies	1.3%
877	Radial Neuropathy	1.3%
878	Median Neuropathy	1.3%
879	Sciatic Nerve Palsy	1.3%
880	Femoral Neuropathy	1.3%
881	Tibial Neuropathy	1.3%
882	Ulnar Nerve Palsy	1.3%
883	Postural Orthostatic Tachycardia Syndrome	1.3%
884	Radial nerve palsy	1.3%
885	Prognathism	1.3%
886	Consciousness Disorders	1.3%
887	Mental Retardation	1.3%
888	Muscle Weakness	1.3%
889	Depressed Level of Consciousness	1.3%
890	Mental deficiency	1.3%
891	Intellectual Disability	1.3%
892	Bell Palsy	1.3%
893	Catatonia	1.3%
894	Herpes Zoster Oticus	1.2%
895	Aphonia	1.2%
896	Long QT Syndrome	1.2%
897	Platybasia	1.2%
898	Sleep Deprivation	1.2%
899	Tricuspid Atresia	1.2%
900	Arrhythmogenic Right Ventricular Dysplasia	1.2%
901	Dysphonia	1.2%
902	Gonadal Dysgenesis	1.2%
903	Bronchomalacia	1.2%
904	Adrenogenital Syndrome	1.2%
905	Tracheomalacia	1.2%
906	Ovotesticular Disorders of Sex Development	1.2%
907	Aortopulmonary Septal Defect	1.2%
908	Double Outlet Right Ventricle	1.2%
909	Endocardial Cushion Defects	1.2%
910	Myocardial bridging	1.2%
911	Aorticopulmonary Septal Defect	1.2%
912	Thoracic Outlet Syndrome	1.1%
913	Myalgia	1.1%
914	Esotropia	1.1%
915	Exotropia	1.1%
916	Hypotension, Orthostatic	1.1%
917	Sleep Apnea Syndromes	1.1%
918	Polymyositis	1.1%
919	Post-Exercise Hypotension	1.1%
920	Disorders of Excessive Somnolence	1.1%
921	Sleep Initiation and Maintenance Disorders	1.1%
922	Night Terrors	1.1%
923	Somnambulism	1.1%
924	Trigeminal Nerve Disorder	1.1%
925	Transient Insomnia	1.1%
926	Sleep Paralysis	1.1%
927	Chronic Insomnia	1.1%
928	REM Sleep Behavior Disorder	1.1%
929	Hypersomnia	1.1%
930	Dysgeusia	1.1%
931	Formication	1.1%
932	Hyperalgesia	1.1%
933	Hyperesthesia	1.1%
934	Hypesthesia	1.1%
935	Language Disorders	1.1%
936	Numbness	1.1%
937	Paresthesia	1.1%
938	Paraparesis, Spastic	1.1%
939	Trismus	1.1%
940	Epilepsia Partialis Continua	1.1%
941	Hypogeusia	1.1%
942	Meningeal Carcinomatosis	1.1%
943	Brown-Sequard Syndrome	1.1%
944	Lockjaw	1.1%
945	Allodynia	1.1%
946	Lead Poisoning, Nervous System, Childhood	1.1%
947	Lead Poisoning, Nervous System, Adult	1.1%
948	Ageusia	1.1%
949	Alexia	1.1%
950	Dyslexia	1.1%
951	Truncus Arteriosus, Persistent	1%
952	Goldenhar Syndrome	1%
953	Mandibulofacial Dysostosis	1%
954	Romano-Ward Syndrome	1%
955	Hoarseness	1%
956	Alcohol Withdrawal Delirium	1%
957	Neurofibrosarcoma	1%
958	Polyradiculopathy	1%
959	Eye Injuries	1%
960	Orbital Myositis	1%
961	Diplopia	0.9%
962	Muscle Rigidity	0.9%
963	Muscle Spasticity	0.9%
964	Scotoma	0.9%
965	Photophobia	0.9%
966	Cogwheel Rigidity	0.9%
967	Hemifacial Spasm	0.9%
968	Amaurosis	0.9%
969	Blindness	0.9%
970	Nuchal Rigidity	0.9%
971	Pyomyositis	0.9%
972	Agnosia	0.9%
973	Apraxias	0.9%
974	Hallucinations	0.9%
975	Hemianopsia	0.9%
976	Hyperacusis	0.9%
977	Tinnitus	0.9%
978	Visual Agnosia	0.9%
979	Anosognosia	0.9%
980	Wernicke-Korsakoff Syndrome	0.9%
981	Phonophobia	0.9%
982	Hearing Loss	0.9%
983	Sarcopenia	0.9%
984	Talipes	0.9%
985	Congenital clubfoot	0.9%
986	Vertical Talus	0.9%
987	Amnesia	0.8%
988	Delirium	0.8%
989	Dissociative Amnesia	0.8%
990	Color blindness	0.8%
991	Global Amnesia	0.8%
992	Meningioma	0.8%
993	Arteriovenous fistula	0.8%
994	Sleep Apnea, Obstructive	0.8%
995	Sleep Apnea, Central	0.8%
996	Narcolepsy	0.8%
997	Trigeminal Neuralgia	0.8%
998	Kleine-Levin Syndrome	0.8%
999	Agraphia	0.8%
1000	Anomia	0.8%
1001	Cluttering	0.8%
1002	Language Development Disorders	0.8%
1003	Speech Disorders	0.8%
1004	Syncope	0.8%
1005	Stupor	0.8%
1006	Dysgraphia	0.8%
1007	Presyncope	0.8%
1008	Dyslalia	0.8%
1009	Phantom pain	0.7%
1010	Phantom Limb Pain	0.7%
1011	Eye Burns	0.7%
1012	Amaurosis Fugax	0.7%
1013	Blindness, Cortical	0.7%
1014	Dyscalculia	0.7%
1015	Deafness	0.7%
1016	Hearing Loss, Sudden	0.7%
1017	Gerstmann Syndrome	0.7%
1018	Hearing Loss, Bilateral	0.7%
1019	Hearing Loss, High-Frequency	0.7%
1020	Hearing Loss, Mixed Conductive-Sensorineural	0.7%
1021	Prosopagnosia	0.7%
1022	Apraxia, Ideomotor	0.7%
1023	Charles Bonnet Syndrome	0.7%
1024	Hearing Loss, Unilateral	0.7%
1025	Complete Hearing Loss	0.7%
1026	Alien Hand Syndrome	0.7%
1027	Deaf Mutism	0.7%
1028	Cataplexy	0.7%
1029	Aphasia	0.7%
1030	Articulation Disorders	0.7%
1031	Echolalia	0.7%
1032	Stuttering	0.7%
1033	Dysphasia	0.7%
1034	Dermatomyositis	0.6%
1035	Corneal Scar	0.6%
1036	Retrograde amnesia	0.6%
1037	Amnesia, Anterograde	0.6%
1038	Dysarthria	0.6%
1039	Mutism	0.6%
1040	Selective Mutism	0.6%
1041	Alexia, Pure	0.5%
1042	Corneal Perforation	0.5%

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