MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Magnesium Deficiency

(UMLS:C0024473)

Definition:: A nutritional condition produced by a deficiency of magnesium in the diet, characterized by anorexia, nausea, vomiting, lethargy, and weakness. Symptoms are paresthesias, muscle cramps, irritability, decreased attention span, and mental confusion, possibly requiring months to appear. Deficiency of body magnesium can exist even when serum values are normal. In addition, magnesium deficiency may be organ-selective, since certain tissues become deficient before others. (Harrison's Principles of Internal Medicine, 12th ed, p1936)
UMLS ID:: C0024473
MeSH ID:: D008275

Classification:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.654.521.500.439

Synonym(s)

Magnesium Deficiency

Magnesium deficiency

deficiency magnesium

deficiency; magnesium

magnesium deficiencies

magnesium deficiency

magnesium; deficiency

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Alendronate	FAERS: 8		US FAERS
2	Esomeprazole	FAERS: 6 Canada Vigilance: 1		Canada Vigilance US FAERS
3	Omeprazole	FAERS: 5		US FAERS
4	Ramipril	FAERS: 5		US FAERS
5	Ciprofloxacin	FAERS: 4		US FAERS
6	Zoledronic Acid	FAERS: 3		US FAERS
7	Dexlansoprazole	FAERS: 2		US FAERS
8	Lansoprazole	FAERS: 2		US FAERS
9	Omeprazole	FAERS: 2	18221401	CTD US FAERS
10	Rabeprazole	FAERS: 2		US FAERS
11	Sertraline	FAERS: 2		US FAERS
12	Thyroxine	FAERS: 2		US FAERS
13	lanreotide	FAERS: 2		US FAERS
14	Alprazolam	FAERS: 1		US FAERS
15	Celecoxib	FAERS: 1		US FAERS
16	Citalopram	FAERS: 1		US FAERS
17	Fexofenadine hydrochloride and pseudoephedrine hydrochloride	FAERS: 1		US FAERS
18	Finasteride	FAERS: 1		US FAERS
19	Fulvestrant	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
20	Ibuprofen	FAERS: 1		US FAERS
21	Lamotrigine	FAERS: 1		US FAERS
22	Levofloxacin	FAERS: 1		US FAERS
23	Nexium 24hr	FAERS: 1		US FAERS
24	Norgestrel	FAERS: 1 Canada Vigilance: 2		Canada Vigilance US FAERS
25	Orlistat	FAERS: 1		OFFSIDES US FAERS
26	Pantoprazole	FAERS: 1		US FAERS
27	Risperidone	FAERS: 1		US FAERS
28	Spironolactone	FAERS: 1		US FAERS
29	Tacrolimus	FAERS: 1		US FAERS
30	Teriparatide	FAERS: 1		US FAERS
31	apixaban	FAERS: 1		US FAERS
32	empagliflozin	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
33	liposomal amphotericin B	FAERS: 1		US FAERS
34	macitentan	FAERS: 1		US FAERS
35	montelukast	FAERS: 1		US FAERS
36	niraparib	FAERS: 1		US FAERS
37	rofecoxib	FAERS: 1		US FAERS
38	rucaparib	FAERS: 1		US FAERS
39	teduglutide	FAERS: 1		US FAERS
40	Budesonide			OFFSIDES
41	Clonidine			OFFSIDES
42	Cocaine		1420262	CTD
43	Digoxin		2311237	CTD
44	Doxorubicin		1966850	CTD
45	Epinephrine		3402518	CTD
46	Foscarnet		8384030	CTD
47	Gentamicins		727798 2331318	CTD
48	Hydrochlorothiazide		23707192	CTD
49	Ketoconazole			OFFSIDES
50	Magnesium		16619211 17823441	CTD
51	Magnesium Sulfate		6069279	CTD
52	Metolazone			OFFSIDES
53	Nitrendipine			OFFSIDES
54	Nitrofurantoin			OFFSIDES
55	Pramipexole			OFFSIDES
56	Ribavirin		17381375	CTD
57	Rivastigmine			OFFSIDES
58	Rosiglitazone		19656910	CTD
59	Sirolimus		19656910	CTD
60	Ubiquinone			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Potassium Deficiency	48.4%
2	Protein Deficiency	48.4%
3	Avitaminosis	48.4%
4	Ascorbic Acid Deficiency	36%
5	Vitamin A Deficiency	36%
6	Vitamin D Deficiency	36%
7	Vitamin E Deficiency	36%
8	Marasmus	36%
9	Starvation	34.4%
10	Refeeding Syndrome	34.4%
11	Folic Acid Deficiency	29.9%
12	Pellagra	29.9%
13	Thiamine Deficiency	29.9%
14	Vitamin B 12 Deficiency	29.9%
15	Vitamin B 6 Deficiency	29.9%
16	Pyridoxine Deficiency	29.9%
17	Beriberi	26.8%
18	Child Nutrition Disorders	25.4%
19	Hypervitaminosis A	25.4%
20	Infant Nutrition Disorders	25.4%
21	Wasting Syndrome	23%
22	Kwashiorkor	22.6%
23	Vitamin K Deficiency	18.4%
24	Anemia, Pernicious	17.9%
25	Metabolic Diseases	16.4%
26	Rickets	16.2%
27	Hyperhomocysteinemia	15.3%
28	Scurvy	15.2%
29	Osteomalacia	13.4%
30	Wernicke Encephalopathy	10.8%
31	Subacute Combined Degeneration	9.4%
32	Acid-Base Imbalance	8.5%
33	Calcium Metabolism Disorders	8.5%
34	Iron Metabolism Disorders	8.5%
35	Phosphorus Metabolism Disorders	8.5%
36	Water-Electrolyte Imbalance	8.5%
37	Lipid Metabolism Disorders	8.5%
38	Mitochondrial Diseases	8.5%
39	Glucose Metabolism Disorders	8.5%
40	Renal Osteodystrophy	8.4%
41	Renal rickets	8.4%
42	Hypercalcemia	6.6%
43	Hypocalcemia	6.6%
44	Milk-Alkali Syndrome	6.6%
45	HIV Wasting Syndrome	6.5%
46	Familial Hypophosphatemic Rickets	6.1%
47	Obesity	5.8%
48	Osteopenia	5.7%
49	Brain Diseases, Metabolic	5.6%
50	Lipodystrophy	5%
51	Acidosis	4.9%
52	Alkalosis	4.9%
53	Amyloidosis	4.9%
54	Calcinosis	4.9%
55	Hyperglycemia	4.9%
56	Hyperinsulinism	4.9%
57	Hyperkalemia	4.9%
58	Hypernatremia	4.9%
59	Hypoglycemia	4.9%
60	Hypokalemia	4.9%
61	Hyponatremia	4.9%
62	Xanthomatosis	4.9%
63	Hypophosphatemia	4.9%
64	Metabolic acidosis	4.9%
65	Dyslipidemias	4.9%
66	Iron Overload	4.9%
67	Xanthoma	4.9%
68	Obesity, Abdominal	4.8%
69	Pseudohypoparathyroidism	4.4%
70	Brain Diseases, Metabolic, Inborn	3.9%
71	Pediatric Obesity	3.8%
72	Diabetes Mellitus	3.5%
73	Leigh Disease	3.4%
74	Dehydration	3.4%
75	Lipomatosis	3.4%
76	Water Intoxication	3.4%
77	Werner Syndrome	3.4%
78	Achlorhydria	3.3%
79	Amino Acid Metabolism, Inborn Errors	3.3%
80	Bloom Syndrome	3.3%
81	Carbohydrate Metabolism, Inborn Errors	3.3%
82	Metal Metabolism, Inborn Errors	3.3%
83	Osteoporosis	3.3%
84	Progeria	3.3%
85	Lysosomal Storage Diseases	3.3%
86	Bone Demineralization, Pathologic	3.3%
87	Cytochrome-c Oxidase Deficiency	3.3%
88	Peroxisomal Disorders	3.3%
89	Post-Traumatic Osteoporosis	3.3%
90	Prader-Willi Syndrome	3.3%
91	Celiac Disease	3.3%
92	Sprue, Tropical	3.3%
93	Steatorrhea	3.3%
94	Sprue	3.3%
95	Lactose Intolerance	3.2%
96	Acidosis, Lactic	3.2%
97	Calciphylaxis	3.2%
98	Hemosiderosis	3.2%
99	Hypolipoproteinemias	3.2%
100	Ketosis	3.2%
101	Ketonuria	3.2%
102	Ketoacidosis	3.2%
103	Ketonemia	3.2%
104	Vascular calcification	3.2%
105	Carbamoyl-Phosphate Synthase I Deficiency Disease	3%
106	Hyperlipoproteinemia Type IV	2.9%
107	Hyperlipoproteinemia Type V	2.9%
108	Diabetic Ketoacidosis	2.8%
109	Hyperlipidemia, Familial Combined	2.8%
110	Smith-Lemli-Opitz Syndrome	2.8%
111	Galactosemias	2.8%
112	Urea Cycle Disorders, Inborn	2.8%
113	Tyrosinemias	2.8%
114	Mitochondrial Encephalomyopathies	2.7%
115	Congenital Hyperinsulinism	2.7%
116	Hyperlipoproteinemia Type III	2.6%
117	Mitochondrial Myopathies	2.5%
118	Myelinolysis, Central Pontine	2.5%
119	Glycosuria	2.5%
120	Reye Syndrome	2.5%
121	Hepatic Encephalopathy	2.4%
122	Hyperphosphaturia	2.4%
123	Hypercholesterolemia	2.4%
124	Hyperlipoproteinemias	2.4%
125	Hypertriglyceridemia	2.4%
126	Hypoalphalipoproteinemias	2.4%
127	Homocystinuria	2.2%
128	Acidosis, Respiratory	2.2%
129	Adiposis Dolorosa	2.2%
130	Alkalosis, Respiratory	2.2%
131	Alkaptonuria	2.2%
132	Glycogen Storage Disease	2.2%
133	Hypophosphatasia	2.2%
134	Insulin Resistance	2.2%
135	Osteoporosis, Postmenopausal	2.2%
136	Propionic acidemia	2.2%
137	Dihydropyrimidine Dehydrogenase Deficiency	2.2%
138	Cystinosis	2.2%
139	Renal tubular acidosis	2.1%
140	Glycogen storage disease type II	2.1%
141	Gaucher Disease	2.1%
142	Amyloid Neuropathies, Familial	2%
143	Porphyrias, Hepatic	2%
144	Necrobiosis Lipoidica Diabeticorum	2%
145	Fanconi Anemia	1.9%
146	Nesidioblastosis	1.9%
147	Neuronal Ceroid-Lipofuscinoses	1.9%
148	HIV-Associated Lipodystrophy Syndrome	1.8%
149	Zellweger Syndrome	1.8%
150	MELAS Syndrome	1.8%
151	Menkes Kinky Hair Syndrome	1.8%
152	Adrenoleukodystrophy	1.7%
153	Gestational Diabetes	1.7%
154	Latent Autoimmune Diabetes in Adults	1.7%
155	Tay-Sachs Disease	1.7%
156	Diabetes Mellitus, Experimental	1.7%
157	Niemann-Pick Disease, Type C	1.6%
158	Hepatolenticular Degeneration	1.6%
159	Nephrocalcinosis	1.6%
160	Tetany	1.6%
161	Friedreich Ataxia	1.6%
162	Refsum Disease	1.6%
163	Glycosuria, Renal	1.6%
164	Cerebral Amyloid Angiopathy	1.6%
165	Glycogen Storage Disease Type I	1.6%
166	Glycogen Storage Disease Type V	1.6%
167	Mucopolysaccharidosis III	1.6%
168	Fabry Disease	1.6%
169	Kernicterus	1.4%
170	Cockayne Syndrome	1.4%
171	Familial Periodic Paralysis	1.3%
172	Primary amyloidosis	1.3%
173	Kearns-Sayre syndrome	1.3%
174	Variegate Porphyria	1.3%
175	Acute intermittent porphyria	1.3%
176	Porphyria Cutanea Tarda	1.3%
177	Renal Aminoacidurias	1.3%
178	Fanconi Syndrome	1.3%
179	Pseudohypoaldosteronism	1.3%
180	Liddle Syndrome	1.3%
181	Ataxia Telangiectasia	1.3%
182	Optic Atrophy, Hereditary, Leber	1.2%
183	Sjogren-Larsson Syndrome	1.1%
184	Xeroderma Pigmentosum	1.1%
185	Gout	1.1%
186	Amyotrophic Lateral Sclerosis	1.1%
187	Antley-Bixler Syndrome Phenotype	1.1%
188	Canavan Disease	1.1%
189	Alexander Disease	1.1%
190	Mucopolysaccharidosis II	1.1%
191	Hypokalemic periodic paralysis	1%
192	Frontotemporal dementia	1%
193	Cystinuria	1%
194	CREST Syndrome	0.9%
195	Albinism	0.8%
196	Arthritis, Gouty	0.8%
197	Ichthyosis, X-Linked	0.7%

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