MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Lymphangiectasis, Intestinal

(UMLS:C0024215)

Definition:: Dilatation of the intestinal lymphatic system usually caused by an obstruction in the intestinal wall. It may be congenital or acquired and is characterized by DIARRHEA; HYPOPROTEINEMIA; peripheral and/or abdominal EDEMA; and PROTEIN-LOSING ENTEROPATHIES.
UMLS ID:: C0024215
MeSH ID:: D008201

Classification 1:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.604.360.500|C15.604.451.500

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.482.500

Synonym(s)

Lymphangiectasis, Intestinal

ENTEROPATHY, HYPERCATABOLIC PROTEIN LOSING

ENTEROPATHY, LYMPHANGIECTATIC PROTEIN-LOSING

HYPOPROTEINEMIA, FAMILIAL, WITH LYMPHANGIECTATIC ENTEROPATHY

Hypercatabolic protein-losing enteropathy

Intestinal lymphangiectasia

Intestinal lymphangiectasia syndrome

Intestinal lymphangiectasis

LYMPHANGIECTASIA, INTESTINAL

10.

LYMPHEDEMA, NEONATAL, DUE TO EXUDATIVE ENTEROPATHY

11.

Lymphangiectasia intestinal

12.

intestinal lymphangiectasia

13.

intestinal lymphangiectasis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	indole-3-carbinol		22328411	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Adenitis	30.5%
2	Histiocytosis	30.5%
3	Lymphadenitis	30.5%
4	Lymphangitis	30.5%
5	Lymphedema	30.5%
6	Splenic Diseases	30.5%
7	Thymus Hyperplasia	30.5%
8	Pseudolymphoma	30.5%
9	Lymphadenopathy	30.5%
10	Lymphocele	24.7%
11	Lymphoproliferative Disorders	24.7%
12	Thymus Neoplasms	24.3%
13	Mucocutaneous Lymph Node Syndrome	20.2%
14	Elephantiasis	20%
15	Hypersplenism	20%
16	Sarcoidosis	20%
17	Elephantiasis Nostras Verrucosa	20%
18	Agammaglobulinemia	18%
19	Heavy Chain Disease	16.6%
20	Granuloma	16.2%
21	Histiocytic Disorders, Malignant	16.2%
22	Splenic Infarction	16.2%
23	Splenic Neoplasms	16.2%
24	Histiocytosis, Langerhans-Cell	16%
25	Tumor Lysis Syndrome	16%
26	Beckwith-Wiedemann Syndrome	15.6%
27	Wolf-Hirschhorn Syndrome	15.6%
28	Abnormalities, Drug-Induced	15.3%
29	Situs Inversus	15.3%
30	Holoprosencephaly	15.2%
31	Infectious Mononucleosis	15.2%
32	Sezary Syndrome	15%
33	Lymphohistiocytosis, Hemophagocytic	14.9%
34	Erdheim-Chester Disease	14.9%
35	Autoimmune Lymphoproliferative Syndrome	14.6%
36	Splenic Rupture	13.6%
37	Lymphoma	13.5%
38	Smith-Magenis syndrome	13.5%
39	Disseminated Intravascular Coagulation	13.3%
40	Lymphangiectasis, Intestinal	13.3%
41	Protein S Deficiency	13.3%
42	Cri-du-Chat Syndrome	13.3%
43	Down Syndrome	13.3%
44	Trisomy 21	13.3%
45	Thymoma	13.3%
46	Waldenstrom Macroglobulinemia	13.2%
47	Aicardi's syndrome	13.1%
48	Thrombocythemia, Essential	12.7%
49	Eye Abnormalities	12.7%
50	Cardiovascular Abnormalities	12.7%
51	Skin Abnormalities	12.3%
52	Lymphatic Abnormalities	12.3%
53	Congenital Microtia	12.3%
54	Thrombasthenia	12.3%
55	Antithrombin III Deficiency	12.3%
56	Protein C Deficiency	12.3%
57	Rubinstein-Taybi Syndrome	12.2%
58	Congenital diaphragmatic hernia	12.1%
59	Malignant histiocytosis	11.9%
60	Sarcoidosis, Pulmonary	11.9%
61	Histiocytic sarcoma	11.9%
62	Ectodermal Dysplasia	11.7%
63	Aplasia Cutis Congenita	11.7%
64	Anencephaly	11.6%
65	Prader-Willi Syndrome	11.6%
66	Afibrinogenemia	11.3%
67	Factor VII Deficiency	11.3%
68	Factor X Deficiency	11.3%
69	Factor XII Deficiency	11.3%
70	Hemophilia A	11.3%
71	Activated Protein C Resistance	11.3%
72	Factor II deficiency	11.3%
73	Factor VIII Deficiency	11.3%
74	Factor V deficiency	11.3%
75	Factor XI Deficiency	11.3%
76	Hypoprothrombinemias	11.3%
77	Urogenital Abnormalities	10.6%
78	Anemia	10.2%
79	Blood Coagulation Disorders	10.2%
80	Blood Platelet Disorders	10.2%
81	Bone Marrow Diseases	10.2%
82	Hemorrhagic Disorders	10.2%
83	Leukocyte Disorders	10.2%
84	Methemoglobinemia	10.2%
85	Pancytopenia	10.2%
86	Polycythemia	10.2%
87	Sulfhemoglobinemia	10.2%
88	Thrombophilia	10.2%
89	Erythrocytosis	10.2%
90	CHARGE Syndrome	10.1%
91	Maxillofacial Abnormalities	10%
92	Dural Arteriovenous Fistula	10%
93	Kartagener Syndrome	10%
94	Prune Belly Syndrome	10%
95	Twins, Conjoined	10%
96	Waardenburg Syndrome	10%
97	Eosinophilic Granuloma	10%
98	Dextrocardia	10%
99	Splenosis	9.9%
100	Anemia, Sickle Cell	9.9%
101	Thalassemia	9.9%
102	Wiskott-Aldrich Syndrome	9.9%
103	Hodgkin Disease	9.9%
104	Lymphoma, Non-Hodgkin	9.9%
105	Leukemia, T-Cell	9.8%
106	Leukemia, B-Cell	9.8%
107	Anemia, Neonatal	9.5%
108	Pelger-Huet Anomaly	9.5%
109	Anemia, Diamond-Blackfan	9.3%
110	Thrombocytosis	9.3%
111	Marfan Syndrome	9.1%
112	Bone Marrow Neoplasms	8.9%
113	Vitamin K Deficiency	8.8%
114	Genetic Diseases, Inborn	8.8%
115	Nail-Patella Syndrome	8.7%
116	Xeroderma	8.7%
117	Mobius Syndrome	8.7%
118	POEMS Syndrome	8.5%
119	Composite Lymphoma	8.5%
120	Transfusion Reaction	8.5%
121	Hypotensive Transfusion Reaction	8.5%
122	Polycythemia Vera	8.4%
123	Lymphangioleiomyomatosis	8.4%
124	Pregnancy Complications, Hematologic	8.2%
125	Hematologic Neoplasms	8.2%
126	Lymphoma, Follicular	8.2%
127	T-Cell Lymphoma	8.2%
128	Mantle cell lymphoma	8.2%
129	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	8.1%
130	Leukemia, Large Granular Lymphocytic	8.1%
131	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	8.1%
132	Anophthalmos	8.1%
133	Anus, Imperforate	8.1%
134	Hydranencephaly	8.1%
135	Microphthalmos	8.1%
136	Neural Tube Defects	8.1%
137	Tethered Cord Syndrome	8.1%
138	Iniencephaly	8.1%
139	Craniorachischisis	8.1%
140	Limb Deformities, Congenital	8.1%
141	Exencephaly	8.1%
142	Septo-Optic Dysplasia	8.1%
143	Craniofacial Abnormalities	8.1%
144	Cortical Dysplasia	8.1%
145	Malformations of Cortical Development	8.1%
146	Anorectal Malformations	8.1%
147	Bloom Syndrome	8%
148	Scimitar Syndrome	7.9%
149	Hemoglobinuria, Paroxysmal	7.9%
150	Leukemoid Reaction	7.9%
151	Microcephaly	7.7%
152	Macrocephaly	7.7%
153	Sickle Cell Trait	7.7%
154	Alstrom Syndrome	7.6%
155	Polycystic Kidney Diseases	7.5%
156	Williams Syndrome	7.5%
157	Abnormalities, Radiation-Induced	7.5%
158	Acrocephalosyndactylia	7.4%
159	Craniosynostosis	7.4%
160	Syndactyly	7.4%
161	Brachycephaly	7.4%
162	Cockayne Syndrome	7.4%
163	Pseudoxanthoma Elasticum	7.4%
164	Fragile X Syndrome	7.3%
165	Lymphoma, T-Cell, Cutaneous	7.3%
166	Lymphoma, AIDS-Related	7.3%
167	Enteropathy-Associated T-Cell Lymphoma	7.3%
168	Primary Effusion Lymphoma	7.3%
169	Purpura, Thrombotic Thrombocytopenic	7.1%
170	Fetal Diseases	7%
171	Classical Lissencephalies and Subcortical Band Heterotopias	7%
172	Porencephaly	7%
173	Turner Syndrome	6.9%
174	Mycosis Fungoides	6.9%
175	Lymphomatoid Papulosis	6.9%
176	Plasmablastic lymphoma	6.9%
177	Retinal Dysplasia	6.8%
178	Blepharophimosis	6.8%
179	Laryngostenosis	6.8%
180	Mouth Abnormalities	6.8%
181	Aniridia	6.8%
182	Esophageal Atresia	6.7%
183	Intestinal Atresia	6.7%
184	Horseshoe Kidney	6.7%
185	Pectus excavatum	6.7%
186	Klippel-Feil Syndrome	6.7%
187	Gastroschisis	6.7%
188	Synostosis	6.7%
189	Acrodermatitis	6.7%
190	Anemia, Hemolytic	6.7%
191	Anemia, Macrocytic	6.7%
192	Eosinophilia	6.7%
193	Epidermolysis Bullosa	6.7%
194	Hypoproteinemia	6.7%
195	Leukopenia	6.7%
196	Noonan Syndrome	6.7%
197	Thrombocytopenia	6.7%
198	Gianotti-Crosti Syndrome	6.7%
199	Leukostasis	6.7%
200	MYELODYSPLASTIC SYNDROME	6.7%
201	Ichthyosis, X-Linked	6.6%
202	Fanconi Anemia	6.6%
203	Smith-Lemli-Opitz Syndrome	6.5%
204	Primary Ciliary Dyskinesia	6.5%
205	Hydrops Fetalis	6.5%
206	Cleft Palate	6.3%
207	Lymphomatoid Granulomatosis	6.3%
208	Jaw Abnormalities	6.1%
209	Acute Chest Syndrome	6.1%
210	Poland Syndrome	6.1%
211	Amelia	6%
212	Arachnodactyly	6%
213	Ectopia Cordis	6%
214	Ectromelia	6%
215	Hemimelia	6%
216	Meningomyelocele	6%
217	Phocomelia	6%
218	Sirenomelia	6%
219	Spina Bifida	6%
220	Polydactyly	6%
221	Brachydactyly	6%
222	Plagiocephaly	6%
223	Lower Extremity Deformities, Congenital	6%
224	Upper Extremity Deformities, Congenital	6%
225	Single umbilical artery	6%
226	Cystic Fibrosis	5.9%
227	Arthrogryposis	5.9%
228	Choanal Atresia	5.9%
229	Tracheobronchomegaly	5.9%
230	Laryngocele	5.9%
231	Choledochal Cyst	5.8%
232	Hermaphroditism	5.8%
233	Disorders of Sex Development	5.8%
234	Autoimmune thrombocytopenia	5.8%
235	Immune thrombocytopenic purpura	5.8%
236	Cryptorchidism	5.8%
237	Hypospadias	5.8%
238	Central Nervous System Cysts	5.7%
239	Dandy-Walker Syndrome	5.7%
240	Klinefelter Syndrome	5.7%
241	Cryoglobulinemia	5.7%
242	Monoclonal Gammopathy of Undetermined Significance	5.7%
243	Polycystic Kidney, Autosomal Dominant	5.6%
244	Chronic granulomatous disease	5.5%
245	Burkitt Lymphoma	5.5%
246	Leukocytosis	5.4%
247	Paraproteinemias	5.4%
248	Pleocytosis	5.4%
249	Sjogren-Larsson Syndrome	5.3%
250	Niemann-Pick Disease, Type C	5.2%
251	Micrognathism	5.2%
252	Pierre Robin Syndrome	5.2%
253	Meconium Aspiration Syndrome	5.1%
254	Laryngomalacia	5.1%
255	Hemolytic-Uremic Syndrome	5.1%
256	Abdominal Cramps	5.1%
257	Amniotic Band Syndrome	5.1%
258	Asphyxia Neonatorum	5.1%
259	Infant, Premature, Diseases	5.1%
260	Infantile Colic	5.1%
261	Pectus carinatum	5.1%
262	Bladder Exstrophy	5%
263	Epispadias	5%
264	Multicystic Dysplastic Kidney	5%
265	Aortic coarctation	5%
266	Cor Triatriatum	5%
267	Coronary Vessel Anomalies	5%
268	Dental Enamel Hypoplasia	5%
269	Patent ductus arteriosus	5%
270	Ebstein Anomaly	5%
271	Heart Septal Defects	5%
272	Hypodontia	5%
273	Macrostomia	5%
274	Meningocele	5%
275	Microstomia	5%
276	Tetralogy of Fallot	5%
277	Transposition of Great Vessels	5%
278	Hypoplastic Left Heart Syndrome	5%
279	May-Thurner Syndrome	5%
280	Encephalocele	5%
281	Primary Myelofibrosis	5%
282	Agranulocytosis	5%
283	Anemia, Megaloblastic	5%
284	Lymphocytosis	5%
285	Myelofibrosis	5%
286	Myeloid Metaplasia	5%
287	Hypoalbuminemia	5%
288	Hypereosinophilic syndrome	5%
289	bone marrow fibrosis	5%
290	Thrombotic Microangiopathies	5%
291	Craniofacial Dysostosis	4.9%
292	Kallmann Syndrome	4.9%
293	Dermal Sinus	4.9%
294	Purpura, Hyperglobulinemic	4.9%
295	Spina Bifida Cystica	4.9%
296	Wolff-Parkinson-White Syndrome	4.9%
297	Spina Bifida Occulta	4.9%
298	Lissencephaly	4.9%
299	Polymicrogyria	4.9%
300	Pachygyria	4.9%
301	Schizencephaly	4.9%
302	Periventricular Nodular Heterotopia	4.9%
303	Charcot-Marie-Tooth Disease	4.9%
304	Antley-Bixler Syndrome Phenotype	4.9%
305	Xeroderma Pigmentosum	4.9%
306	Hyperkeratosis, Epidermolytic	4.9%
307	Retrognathia	4.7%
308	Thrombocytopenic purpura	4.6%
309	Zellweger Syndrome	4.6%
310	Hypergammaglobulinemia	4.5%
311	Transfusion-Related Acute Lung Injury	4.5%
312	Kernicterus	4.5%
313	Ecchymosis	4.4%
314	Petechiae	4.4%
315	Purpura	4.4%
316	Multiple Myeloma	4.4%
317	Hyperandrogenism	4.4%
318	Basal Cell Nevus Syndrome	4.4%
319	Atypical Hemolytic Uremic Syndrome	4.4%
320	Tuberous Sclerosis	4.4%
321	Long QT Syndrome	4.3%
322	Platybasia	4.3%
323	Tricuspid Atresia	4.3%
324	Arrhythmogenic Right Ventricular Dysplasia	4.3%
325	Gonadal Dysgenesis	4.2%
326	Bronchomalacia	4.2%
327	Adrenogenital Syndrome	4.2%
328	Tracheomalacia	4.2%
329	Ovotesticular Disorders of Sex Development	4.2%
330	Prognathism	4.2%
331	Neoplastic Syndromes, Hereditary	4.2%
332	Refsum Disease	4.2%
333	Neutropenia	4.1%
334	Aortopulmonary Septal Defect	4.1%
335	Double Outlet Right Ventricle	4.1%
336	Endocardial Cushion Defects	4.1%
337	Myocardial bridging	4.1%
338	Aorticopulmonary Septal Defect	4.1%
339	Multiple Epiphyseal Dysplasia	4.1%
340	Osteochondrodysplasias	4.1%
341	Persistent Fetal Circulation Syndrome	4.1%
342	Werner Syndrome	4.1%
343	Myasthenic Syndromes, Congenital	4.1%
344	Lymphopenia	4%
345	Umbilical hernia	4%
346	Job Syndrome	4%
347	Leukemia, Myelomonocytic, Chronic	3.9%
348	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	3.9%
349	Waterhouse-Friderichsen Syndrome	3.8%
350	Muscular Dystrophy, Duchenne	3.8%
351	Febrile Neutropenia	3.7%
352	Albinism	3.7%
353	Truncus Arteriosus, Persistent	3.7%
354	Goldenhar Syndrome	3.6%
355	Mandibulofacial Dysostosis	3.5%
356	Romano-Ward Syndrome	3.5%
357	Dwarfism	3.5%
358	Neonatal Abstinence Syndrome	3.4%
359	Fetal Growth Retardation	3.4%
360	Muscular Dystrophy	3.4%
361	Osteogenesis Imperfecta	3.4%
362	Eosinophilia-Myalgia Syndrome	3.4%
363	Fetal Hypoxia	3.4%
364	Congenital nystagmus	3.4%
365	Fetal Alcohol Spectrum Disorders	3.4%
366	Pulmonary Eosinophilia	3.3%
367	Eosinophilic Pneumonia	3.3%
368	Familial Mediterranean Fever	3.3%
369	Toxoplasmosis, Congenital	3.3%
370	Shwartzman Phenomenon	3.3%
371	Syphilis, Congenital	3.3%
372	Hemangioma, Cavernous	3.3%
373	Scurvy	3.3%
374	Purpura Fulminans	3.3%
375	Rett Syndrome	3.3%
376	Leukemia, Myeloid, Chronic-Phase	3.3%
377	Anemia, Pernicious	3.3%
378	Mucopolysaccharidosis II	3.2%
379	Talipes	3.2%
380	Menkes Kinky Hair Syndrome	3%
381	Congenital clubfoot	3%
382	Vertical Talus	3%
383	Congenital Hyperinsulinism	2.9%
384	Chorioamnionitis	2.9%
385	Angioedemas, Hereditary	2.8%
386	Arteriovenous fistula	2.7%
387	Paralysis, Obstetric	2.7%
388	Retinopathy of Prematurity	2.7%
389	Amino Acid Metabolism, Inborn Errors	2.7%
390	Carbohydrate Metabolism, Inborn Errors	2.7%
391	Metal Metabolism, Inborn Errors	2.7%
392	Progeria	2.7%
393	Lysosomal Storage Diseases	2.7%
394	Cytochrome-c Oxidase Deficiency	2.7%
395	Peroxisomal Disorders	2.7%
396	Neuronal Ceroid-Lipofuscinoses	2.7%
397	Bronchopulmonary Dysplasia	2.6%
398	Myotonic Dystrophy	2.6%
399	Adrenoleukodystrophy	2.5%
400	Hepatolenticular Degeneration	2.4%
401	Fabry Disease	2.3%
402	Amyloid Neuropathies, Familial	2.3%
403	Respiratory Distress Syndrome, Newborn	2.3%
404	Denys-Drash Syndrome	2.3%
405	Cutis Laxa	2.2%
406	Retinitis Pigmentosa	2.2%
407	Pigmentary retinopathy	2.2%
408	Porokeratosis	2.2%
409	Keratoderma, Palmoplantar	2.2%
410	Welander Distal Myopathy	2.2%
411	Glycogen storage disease type II	2.2%
412	Ophthalmia Neonatorum	2.2%
413	Galactosemias	2.2%
414	Urea Cycle Disorders, Inborn	2.2%
415	Tyrosinemias	2.2%
416	Mucopolysaccharidosis III	2%
417	Ataxia Telangiectasia	2%
418	Alkaptonuria	2%
419	Glycogen Storage Disease	2%
420	Hypophosphatasia	2%
421	Propionic acidemia	2%
422	Dihydropyrimidine Dehydrogenase Deficiency	2%
423	Cystinosis	2%
424	Optic Atrophy, Hereditary, Leber	2%
425	Hyperphosphaturia	2%
426	Duane Retraction Syndrome	1.9%
427	Canavan Disease	1.9%
428	Alexander Disease	1.9%
429	Porphyrias, Hepatic	1.9%
430	Peutz-Jeghers Syndrome	1.9%
431	Myotonia Congenita	1.9%
432	Brain Diseases, Metabolic, Inborn	1.9%
433	Dystonia Musculorum Deformans	1.9%
434	Leukomalacia, Periventricular	1.9%
435	Nesidioblastosis	1.9%
436	Lafora Disease	1.9%
437	Unverricht-Lundborg Syndrome	1.9%
438	Homocystinuria	1.8%
439	Gaucher Disease	1.8%
440	Leigh Disease	1.8%
441	Multiple Endocrine Neoplasia	1.7%
442	Congenital Hypothyroidism	1.7%
443	Dermatitis, Atopic	1.7%
444	Hyaline Membrane Disease	1.7%
445	Tay-Sachs Disease	1.6%
446	Hypolipoproteinemias	1.6%
447	Papillon-Lefevre Disease	1.6%
448	Hyperlipidemia, Familial Combined	1.6%
449	Glycogen Storage Disease Type I	1.6%
450	Glycogen Storage Disease Type V	1.6%
451	Hyperlipoproteinemia Type III	1.6%
452	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.6%
453	Behcet Syndrome	1.5%
454	Familial Periodic Paralysis	1.4%
455	Lactose Intolerance	1.4%
456	Variegate Porphyria	1.4%
457	Acute intermittent porphyria	1.4%
458	Porphyria Cutanea Tarda	1.4%
459	Hyperhomocysteinemia	1.4%
460	Renal Aminoacidurias	1.4%
461	Fanconi Syndrome	1.4%
462	Pseudohypoaldosteronism	1.4%
463	Liddle Syndrome	1.4%
464	Hyperlipoproteinemia Type IV	1.4%
465	Hyperlipoproteinemia Type V	1.4%
466	Hypoalphalipoproteinemias	1.4%
467	Huntington Disease	1.3%
468	Gout	1.3%
469	Multiple Endocrine Neoplasia Type 1	1.2%
470	Pseudohypoparathyroidism	1.2%
471	Friedreich Ataxia	1.2%
472	Renal tubular acidosis	1.2%
473	Nephroblastoma	1.2%
474	Hypokalemic periodic paralysis	1.2%
475	Cystinuria	1.2%
476	Adenomatous Polyposis Coli	1.1%
477	Familial Hypophosphatemic Rickets	1.1%
478	Arthritis, Gouty	1%
479	Glycosuria, Renal	1%
480	MELAS Syndrome	0.8%

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