MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hyperlipoproteinemia Type III

(UMLS:C0020479)

Definition:: An autosomal recessively inherited disorder characterized by the accumulation of intermediate-density lipoprotein (IDL or broad-beta-lipoprotein). IDL has a CHOLESTEROL to TRIGLYCERIDES ratio greater than that of VERY-LOW-DENSITY LIPOPROTEINS. This disorder is due to mutation of APOLIPOPROTEINS E, a receptor-binding component of VLDL and CHYLOMICRONS, resulting in their reduced clearance and high plasma levels of both cholesterol and triglycerides.
UMLS ID:: C0020479
MeSH ID:: D006952

Classification 1:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.565.398.483

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.584.500.500.644.485|C18.452.648.398.483

Synonym(s)

Hyperlipoproteinemia Type III

Apolipoprotein E deficiency

BROAD BETA DISEASE

Broad beta disease

Broad-beta disease

Carbohydrate induced hyperlipemia

DYSBETALIPOPROTEINEMIA

Dysbetalipoproteinemia

Familial dysbetalipoproteinaemia

10.

Familial dysbetalipoproteinemia

11.

Familial hyperbetalipoproteinemia and hyperprebetalipoproteinemia

12.

Familial hypercholesterolemia with hyperlipemia

13.

Familial type 3 hyperlipoproteinaemia

14.

Familial type 3 hyperlipoproteinemia

15.

Familial type III hyperlipoproteinaemia

16.

Familial type III hyperlipoproteinemia

17.

Floating beta disease

18.

Frederickson type III hyperlipidemia

19.

Fredrickson type III hyperlipoproteinaemia

20.

Fredrickson type III hyperlipoproteinemia

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Niacin		12506591	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Hyperlipoproteinemia Type IV	53.9%
2	Hyperlipoproteinemia Type V	53.9%
3	Hyperlipidemia, Familial Combined	48.9%
4	Hypolipoproteinemias	47.4%
5	Smith-Lemli-Opitz Syndrome	44.2%
6	Hypoalphalipoproteinemias	33.5%
7	Amino Acid Metabolism, Inborn Errors	31.7%
8	Carbohydrate Metabolism, Inborn Errors	31.7%
9	Metal Metabolism, Inborn Errors	31.7%
10	Progeria	31.7%
11	Lysosomal Storage Diseases	31.7%
12	Peroxisomal Disorders	31.7%
13	Brain Diseases, Metabolic, Inborn	30%
14	Neuronal Ceroid-Lipofuscinoses	28.7%
15	Galactosemias	26.1%
16	Urea Cycle Disorders, Inborn	26.1%
17	Tyrosinemias	26.1%
18	Leigh Disease	25.9%
19	Pseudohypoparathyroidism	25.7%
20	Wasting Syndrome	24.7%
21	Gaucher Disease	24.3%
22	Cytochrome-c Oxidase Deficiency	23.9%
23	Hyperphosphaturia	23.5%
24	Acid-Base Imbalance	22.8%
25	Calcium Metabolism Disorders	22.8%
26	Iron Metabolism Disorders	22.8%
27	Phosphorus Metabolism Disorders	22.8%
28	Water-Electrolyte Imbalance	22.8%
29	Mitochondrial Diseases	22.8%
30	Glucose Metabolism Disorders	22.8%
31	Hyperhomocysteinemia	22.6%
32	Hypercholesterolemia	22.2%
33	Hypertriglyceridemia	22.2%
34	Glycogen storage disease type II	22.1%
35	Carbamoyl-Phosphate Synthase I Deficiency Disease	22%
36	Lipodystrophy	22%
37	Lactose Intolerance	21.9%
38	Fabry Disease	21.4%
39	Menkes Kinky Hair Syndrome	21.1%
40	Homocystinuria	20.9%
41	Sjogren-Larsson Syndrome	20.5%
42	Hypercalcemia	20.5%
43	Hypocalcemia	20.5%
44	Milk-Alkali Syndrome	20.5%
45	Alkaptonuria	20.4%
46	Glycogen Storage Disease	20.4%
47	Hypophosphatasia	20.4%
48	Propionic acidemia	20.4%
49	Dihydropyrimidine Dehydrogenase Deficiency	20.4%
50	Cystinosis	20.4%
51	Werner Syndrome	20.3%
52	Xanthomatosis	20%
53	Xanthoma	20%
54	Tay-Sachs Disease	19.6%
55	Niemann-Pick Disease, Type C	19.5%
56	Adrenoleukodystrophy	19.5%
57	Hepatolenticular Degeneration	19.2%
58	Zellweger Syndrome	19.1%
59	Refsum Disease	18.7%
60	Mucopolysaccharidosis III	18.5%
61	Osteopenia	18.5%
62	Brain Diseases, Metabolic	18.3%
63	Amyloid Neuropathies, Familial	17.5%
64	Mucopolysaccharidosis II	17%
65	Renal tubular acidosis	16.6%
66	Albinism	16.3%
67	Lipomatosis	16.3%
68	Familial Hypophosphatemic Rickets	15.8%
69	Rickets	15.4%
70	Familial Periodic Paralysis	14.9%
71	Ichthyosis, X-Linked	14.8%
72	Glycogen Storage Disease Type I	14.8%
73	Glycogen Storage Disease Type V	14.8%
74	Nutrition Disorders	14.6%
75	Renal Aminoacidurias	14.5%
76	Fanconi Syndrome	14.5%
77	Pseudohypoaldosteronism	14.5%
78	Liddle Syndrome	14.5%
79	Antley-Bixler Syndrome Phenotype	13.6%
80	Cockayne Syndrome	13.4%
81	Glycosuria, Renal	13.3%
82	Gout	13%
83	MELAS Syndrome	12.9%
84	Acidosis	12.7%
85	Alkalosis	12.7%
86	Amyloidosis	12.7%
87	Calcinosis	12.7%
88	Hyperglycemia	12.7%
89	Hyperinsulinism	12.7%
90	Hyperkalemia	12.7%
91	Hypernatremia	12.7%
92	Hypoglycemia	12.7%
93	Hypokalemia	12.7%
94	Hyponatremia	12.7%
95	Hypophosphatemia	12.7%
96	Metabolic acidosis	12.7%
97	Iron Overload	12.7%
98	Lipid Metabolism Disorders	12.3%
99	Bloom Syndrome	12.2%
100	Porphyrias, Hepatic	11.7%
101	Congenital Hyperinsulinism	11.6%
102	Canavan Disease	11.4%
103	Alexander Disease	11.4%
104	Fanconi Anemia	11.4%
105	Hypokalemic periodic paralysis	10.7%
106	Diabetes Mellitus	10.7%
107	Cystinuria	10.6%
108	Dehydration	10.4%
109	Water Intoxication	10.4%
110	Mitochondrial Encephalomyopathies	10.3%
111	Neoplastic Syndromes, Hereditary	10.3%
112	Achlorhydria	10.2%
113	Osteoporosis	10.2%
114	Bone Demineralization, Pathologic	10.2%
115	Post-Traumatic Osteoporosis	10.2%
116	Ataxia Telangiectasia	10.2%
117	Celiac Disease	10.2%
118	Sprue, Tropical	10.2%
119	Steatorrhea	10.2%
120	Sprue	10.2%
121	CHARGE Syndrome	9.9%
122	Multiple Epiphyseal Dysplasia	9.9%
123	Osteochondrodysplasias	9.9%
124	Pelger-Huet Anomaly	9.9%
125	Myasthenic Syndromes, Congenital	9.9%
126	Cystic Fibrosis	9.7%
127	Osteomalacia	9.6%
128	Adiposis Dolorosa	9.5%
129	Arthritis, Gouty	9.3%
130	Aicardi's syndrome	9.2%
131	Optic Atrophy, Hereditary, Leber	9%
132	Diabetic Ketoacidosis	8.9%
133	HIV-Associated Lipodystrophy Syndrome	8.8%
134	Friedreich Ataxia	8.8%
135	Mitochondrial Myopathies	8.7%
136	Myelinolysis, Central Pontine	8.6%
137	Nail-Patella Syndrome	8.6%
138	Dwarfism	8.5%
139	HIV Wasting Syndrome	8.5%
140	Glycosuria	8.5%
141	Reye Syndrome	8.5%
142	Hepatic Encephalopathy	8.5%
143	Xeroderma Pigmentosum	8.4%
144	Anemia, Sickle Cell	8.4%
145	Thalassemia	8.4%
146	Muscular Dystrophy, Duchenne	8.3%
147	Muscular Dystrophy	8.2%
148	Osteogenesis Imperfecta	8.2%
149	Beckwith-Wiedemann Syndrome	8.2%
150	Wolf-Hirschhorn Syndrome	8.2%
151	Fragile X Syndrome	8%
152	Acidosis, Lactic	7.8%
153	Calciphylaxis	7.8%
154	Hemosiderosis	7.8%
155	Ketosis	7.8%
156	Ketonuria	7.8%
157	Ketoacidosis	7.8%
158	Ketonemia	7.8%
159	Vascular calcification	7.8%
160	Deformity	7.6%
161	Nesidioblastosis	7.6%
162	Child Nutrition Disorders	7.6%
163	Hypervitaminosis A	7.6%
164	Infant Nutrition Disorders	7.6%
165	Malnutrition	7.6%
166	Prader-Willi Syndrome	7.4%
167	Necrobiosis Lipoidica Diabeticorum	7.3%
168	Familial Mediterranean Fever	7.3%
169	Dyslipidemias	7.3%
170	Variegate Porphyria	7.3%
171	Acute intermittent porphyria	7.3%
172	Porphyria Cutanea Tarda	7.3%
173	Autoimmune Lymphoproliferative Syndrome	7.2%
174	Smith-Magenis syndrome	7.1%
175	Wernicke Encephalopathy	7%
176	Cri-du-Chat Syndrome	7%
177	Down Syndrome	7%
178	Angioedemas, Hereditary	7%
179	Trisomy 21	7%
180	Kernicterus	6.9%
181	Renal Osteodystrophy	6.8%
182	Renal rickets	6.8%
183	Alstrom Syndrome	6.8%
184	Marfan Syndrome	6.7%
185	Wiskott-Aldrich Syndrome	6.5%
186	Rett Syndrome	6.4%
187	Kartagener Syndrome	6.4%
188	Acidosis, Respiratory	6.3%
189	Alkalosis, Respiratory	6.3%
190	Insulin Resistance	6.3%
191	Osteoporosis, Postmenopausal	6.3%
192	Holoprosencephaly	6.2%
193	Fetal Diseases	6.2%
194	Ectodermal Dysplasia	6.2%
195	Aplasia Cutis Congenita	6.2%
196	Kallmann Syndrome	6%
197	Myotonic Dystrophy	5.9%
198	Kearns-Sayre syndrome	5.6%
199	Polycystic Kidney Diseases	5.5%
200	Williams Syndrome	5.5%
201	Rubinstein-Taybi Syndrome	5.5%
202	Sickle Cell Trait	5.5%
203	Tuberous Sclerosis	5.4%
204	Primary Ciliary Dyskinesia	5.4%
205	Gestational Diabetes	5.4%
206	Latent Autoimmune Diabetes in Adults	5.4%
207	Diabetes Mellitus, Experimental	5.3%
208	Nephrocalcinosis	5.2%
209	Tetany	5.2%
210	Cerebral Amyloid Angiopathy	5.2%
211	Retinal Dysplasia	5%
212	Aniridia	5%
213	Cutis Laxa	5%
214	Retinitis Pigmentosa	4.9%
215	Pigmentary retinopathy	4.9%
216	Epidermolysis Bullosa	4.9%
217	Porokeratosis	4.9%
218	Keratoderma, Palmoplantar	4.9%
219	Chronic granulomatous disease	4.9%
220	Welander Distal Myopathy	4.8%
221	Primary amyloidosis	4.5%
222	Acute Chest Syndrome	4.4%
223	Duane Retraction Syndrome	4.3%
224	Deficiency Diseases	4.2%
225	Starvation	4.2%
226	Refeeding Syndrome	4.2%
227	Meconium Aspiration Syndrome	4.2%
228	Peutz-Jeghers Syndrome	4.2%
229	Myotonia Congenita	4.2%
230	Thrombasthenia	4.2%
231	Antithrombin III Deficiency	4.2%
232	Protein C Deficiency	4.2%
233	Afibrinogenemia	4.2%
234	Dystonia Musculorum Deformans	4.2%
235	Factor VII Deficiency	4.2%
236	Factor X Deficiency	4.2%
237	Factor XII Deficiency	4.2%
238	Hemophilia A	4.2%
239	Activated Protein C Resistance	4.2%
240	Factor II deficiency	4.2%
241	Factor VIII Deficiency	4.2%
242	Factor V deficiency	4.2%
243	Factor XI Deficiency	4.2%
244	Hypoprothrombinemias	4.2%
245	Lafora Disease	4.1%
246	Unverricht-Lundborg Syndrome	4.1%
247	Anemia, Diamond-Blackfan	4.1%
248	Abdominal Cramps	4.1%
249	Abnormalities, Drug-Induced	4.1%
250	Amniotic Band Syndrome	4.1%
251	Asphyxia Neonatorum	4.1%
252	Infant, Premature, Diseases	4.1%
253	Situs Inversus	4.1%
254	Infantile Colic	4.1%
255	Hyperlipoproteinemia Type III	4%
256	Amyotrophic Lateral Sclerosis	4%
257	Pseudoxanthoma Elasticum	4%
258	Multiple Endocrine Neoplasia	3.8%
259	Xeroderma	3.8%
260	Mobius Syndrome	3.8%
261	Congenital Hypothyroidism	3.7%
262	Dermatitis, Atopic	3.7%
263	Polycystic Kidney, Autosomal Dominant	3.7%
264	Hyperlipoproteinemias	3.6%
265	Classical Lissencephalies and Subcortical Band Heterotopias	3.5%
266	CREST Syndrome	3.5%
267	Eye Abnormalities	3.4%
268	Cardiovascular Abnormalities	3.4%
269	Hyperkeratosis, Epidermolytic	3.4%
270	Skin Abnormalities	3.3%
271	Lymphatic Abnormalities	3.3%
272	Congenital Microtia	3.3%
273	Anemia, Neonatal	3.3%
274	Persistent Fetal Circulation Syndrome	3.3%
275	Behcet Syndrome	3.3%
276	Congenital diaphragmatic hernia	3.3%
277	Umbilical hernia	3.3%
278	Basal Cell Nevus Syndrome	3.3%
279	Charcot-Marie-Tooth Disease	3.2%
280	Papillon-Lefevre Disease	3.2%
281	Frontotemporal dementia	3.1%
282	Huntington Disease	2.9%
283	Urogenital Abnormalities	2.9%
284	Neonatal Abstinence Syndrome	2.8%
285	Fetal Growth Retardation	2.8%
286	Fetal Hypoxia	2.7%
287	Congenital nystagmus	2.7%
288	Fetal Alcohol Spectrum Disorders	2.7%
289	Toxoplasmosis, Congenital	2.7%
290	Anencephaly	2.7%
291	Syphilis, Congenital	2.7%
292	Nephroblastoma	2.7%
293	Kwashiorkor	2.6%
294	Magnesium Deficiency	2.6%
295	Potassium Deficiency	2.6%
296	Protein Deficiency	2.6%
297	Avitaminosis	2.6%
298	Hydrops Fetalis	2.5%
299	Multiple Endocrine Neoplasia Type 1	2.4%
300	Prune Belly Syndrome	2.4%
301	Twins, Conjoined	2.4%
302	Waardenburg Syndrome	2.4%
303	Adenomatous Polyposis Coli	2.4%
304	Klinefelter Syndrome	2.4%
305	Obesity	2.4%
306	Chorioamnionitis	2.4%
307	Maxillofacial Abnormalities	2.4%
308	Dural Arteriovenous Fistula	2.4%
309	Dextrocardia	2.3%
310	Turner Syndrome	2.2%
311	Abnormalities, Radiation-Induced	2%
312	Anophthalmos	2%
313	Anus, Imperforate	2%
314	Hydranencephaly	2%
315	Microphthalmos	2%
316	Neural Tube Defects	2%
317	Paralysis, Obstetric	2%
318	Retinopathy of Prematurity	2%
319	Tethered Cord Syndrome	2%
320	Iniencephaly	2%
321	Craniorachischisis	2%
322	Limb Deformities, Congenital	2%
323	Exencephaly	2%
324	Septo-Optic Dysplasia	2%
325	Craniofacial Abnormalities	2%
326	Cortical Dysplasia	2%
327	Malformations of Cortical Development	2%
328	Anorectal Malformations	2%
329	Bronchopulmonary Dysplasia	1.9%
330	Scimitar Syndrome	1.9%
331	Ophthalmia Neonatorum	1.8%
332	Ascorbic Acid Deficiency	1.8%
333	Vitamin A Deficiency	1.8%
334	Vitamin D Deficiency	1.8%
335	Vitamin E Deficiency	1.8%
336	Marasmus	1.8%
337	Obesity, Abdominal	1.7%
338	Blepharophimosis	1.7%
339	Laryngostenosis	1.7%
340	Mouth Abnormalities	1.7%
341	Respiratory Distress Syndrome, Newborn	1.7%
342	Esophageal Atresia	1.7%
343	Intestinal Atresia	1.7%
344	Horseshoe Kidney	1.7%
345	Pectus excavatum	1.7%
346	Klippel-Feil Syndrome	1.6%
347	Gastroschisis	1.6%
348	Synostosis	1.6%
349	Acrodermatitis	1.6%
350	Lymphangiectasis, Intestinal	1.6%
351	Gianotti-Crosti Syndrome	1.6%
352	Craniosynostosis	1.6%
353	Syndactyly	1.6%
354	Brachycephaly	1.6%
355	Microcephaly	1.6%
356	Macrocephaly	1.6%
357	Denys-Drash Syndrome	1.6%
358	Pediatric Obesity	1.5%
359	Acrocephalosyndactylia	1.5%
360	Noonan Syndrome	1.5%
361	Arthrogryposis	1.4%
362	Choanal Atresia	1.4%
363	Tracheobronchomegaly	1.4%
364	Laryngocele	1.4%
365	Choledochal Cyst	1.4%
366	Hermaphroditism	1.4%
367	Disorders of Sex Development	1.4%
368	Cryptorchidism	1.4%
369	Hypospadias	1.4%
370	Central Nervous System Cysts	1.4%
371	Dandy-Walker Syndrome	1.4%
372	Folic Acid Deficiency	1.4%
373	Pellagra	1.4%
374	Thiamine Deficiency	1.4%
375	Vitamin B 12 Deficiency	1.4%
376	Vitamin B 6 Deficiency	1.4%
377	Pyridoxine Deficiency	1.4%
378	Leukomalacia, Periventricular	1.4%
379	POEMS Syndrome	1.4%
380	Porencephaly	1.4%
381	Amelia	1.3%
382	Arachnodactyly	1.3%
383	Ectopia Cordis	1.3%
384	Ectromelia	1.3%
385	Hemimelia	1.3%
386	Meningomyelocele	1.3%
387	Phocomelia	1.3%
388	Sirenomelia	1.3%
389	Spina Bifida	1.3%
390	Polydactyly	1.3%
391	Brachydactyly	1.3%
392	Plagiocephaly	1.3%
393	Lower Extremity Deformities, Congenital	1.3%
394	Upper Extremity Deformities, Congenital	1.3%
395	Single umbilical artery	1.3%
396	Cleft Palate	1.3%
397	Jaw Abnormalities	1.3%
398	Laryngomalacia	1.3%
399	Pectus carinatum	1.3%
400	Bladder Exstrophy	1.2%
401	Epispadias	1.2%
402	Multicystic Dysplastic Kidney	1.2%
403	Vitamin K Deficiency	1.2%
404	Poland Syndrome	1.2%
405	Beriberi	1.2%
406	Aortic coarctation	1.1%
407	Cor Triatriatum	1.1%
408	Coronary Vessel Anomalies	1.1%
409	Dental Enamel Hypoplasia	1.1%
410	Patent ductus arteriosus	1.1%
411	Ebstein Anomaly	1.1%
412	Heart Septal Defects	1.1%
413	Hyaline Membrane Disease	1.1%
414	Hypodontia	1.1%
415	Macrostomia	1.1%
416	Meningocele	1.1%
417	Microstomia	1.1%
418	Tetralogy of Fallot	1.1%
419	Transposition of Great Vessels	1.1%
420	Hypoplastic Left Heart Syndrome	1.1%
421	May-Thurner Syndrome	1.1%
422	Encephalocele	1.1%
423	Craniofacial Dysostosis	1.1%
424	Wolff-Parkinson-White Syndrome	1.1%
425	Micrognathism	1%
426	Pierre Robin Syndrome	1%
427	Dermal Sinus	1%
428	Spina Bifida Cystica	1%
429	Spina Bifida Occulta	1%
430	Lissencephaly	1%
431	Polymicrogyria	1%
432	Pachygyria	1%
433	Schizencephaly	1%
434	Periventricular Nodular Heterotopia	1%
435	Anemia, Pernicious	1%
436	Scurvy	0.9%
437	Long QT Syndrome	0.9%
438	Platybasia	0.9%
439	Tricuspid Atresia	0.9%
440	Arrhythmogenic Right Ventricular Dysplasia	0.9%
441	Gonadal Dysgenesis	0.9%
442	Bronchomalacia	0.9%
443	Adrenogenital Syndrome	0.9%
444	Tracheomalacia	0.9%
445	Ovotesticular Disorders of Sex Development	0.9%
446	Retrognathia	0.9%
447	Hyperandrogenism	0.9%
448	Prognathism	0.8%
449	Aortopulmonary Septal Defect	0.8%
450	Double Outlet Right Ventricle	0.8%
451	Endocardial Cushion Defects	0.8%
452	Myocardial bridging	0.8%
453	Aorticopulmonary Septal Defect	0.8%
454	Mandibulofacial Dysostosis	0.7%
455	Romano-Ward Syndrome	0.7%
456	Truncus Arteriosus, Persistent	0.7%
457	Goldenhar Syndrome	0.7%
458	Subacute Combined Degeneration	0.6%
459	Talipes	0.6%
460	Arteriovenous fistula	0.5%
461	Congenital clubfoot	0.5%
462	Vertical Talus	0.5%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234