MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Kashin-Beck Disease

(UMLS:C2745963)

Definition:: Disabling osteochondrodysplasia with OSTEOSCLEROSIS, cone-shaped METAPHYSIS, and shortening of the DIAPHYSIS. It is endemic in parts of Siberia and northern China. Mineral deficiencies (e.g., selenium, iodine), fungal cereal contamination, and water contamination may be contributing factors in its etiology.
UMLS ID:: C2745963
MeSH ID:: D057767

Classification:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.099.708.534

Synonym(s)

Kashin-Beck Disease

Endemic polyarthritis

Kaschin-Beck

Kaschin-Beck disease

Kaschin-Beck disease (endemic polyarthritis)

Kaschin-Beck disease, site unspecified

Kaschin-Beck disease, unspecified site

Kaschin-Bek disease

Kashin-Beck disease

10.

Kashin-Bek disease

11.

Osteoarthritis deformans

12.

Osteoarthrosis deformans

13.

Urov disease

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Selenium	View details 8291220 8435081 10090708 10398891	CTD
2	T-2 Toxin	21144892 29079362	CTD
3	fulvic acid	View details 8291220 8435081 10090708 10398891	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Chondrodysplasia Punctata	48.4%
2	Enchondromatosis	48.4%
3	Osteosclerosis	48.4%
4	Melorheostosis	36%
5	Osteopetrosis	36%
6	Dysostoses	34.4%
7	Hyperostosis	25.4%
8	Osteitis	25.4%
9	Osteitis Deformans	25.4%
10	Osteochondrosis	25.4%
11	Spinal Diseases	25.4%
12	Osteogenesis Imperfecta	25%
13	Gigantism	24.8%
14	Osteoarthropathy, Secondary Hypertrophic	23%
15	Pectus excavatum	21.8%
16	Platybasia	21.7%
17	Dwarfism	18.6%
18	Bone Diseases, Endocrine	18.1%
19	Pectus carinatum	17.5%
20	Bone Diseases, Infectious	17.2%
21	Bone neoplasms	17.2%
22	Osteopenia	17.2%
23	Osteochondritis	17.1%
24	Bone Resorption	16.9%
25	Aseptic Necrosis of Bone	16.9%
26	Fasciitis	16.4%
27	Foot Deformities	16.4%
28	Arthropathy	16.4%
29	Klippel-Feil Syndrome	15.8%
30	Synostosis	15.8%
31	Spinal Neoplasms	14.9%
32	Spondylitis	14.9%
33	Ainhum	14.8%
34	Spinal Stenosis	14.8%
35	Spondylosis	14.8%
36	Intervertebral Disc Degeneration	14.8%
37	Craniofacial Dysostosis	13.8%
38	Congenital Hypothyroidism	12.8%
39	Contracture	11.5%
40	Fasciitis, Plantar	11.5%
41	Jaw Diseases	11.4%
42	Cartilage Diseases	10.8%
43	Foot Diseases	10.8%
44	Myopathy	10.8%
45	Rheumatism	10.8%
46	Chondromalacia	10.8%
47	Arthrogryposis	10.3%
48	Osteomyelitis	9.9%
49	Osteoporosis	9.9%
50	Periostitis	9.9%
51	Bone Demineralization, Pathologic	9.9%
52	Post-Traumatic Osteoporosis	9.9%
53	Alveolar Bone Loss	9.8%
54	Femur Head Necrosis	9.8%
55	Osteolysis	9.8%
56	Discitis	9.7%
57	Lordosis	9.7%
58	Spondylolysis	9.7%
59	kyphosis	9.7%
60	Craniosynostosis	8.9%
61	Syndactyly	8.9%
62	Brachycephaly	8.9%
63	Marfan Syndrome	8.8%
64	Fibromyalgia	8.5%
65	Polymyalgia Rheumatica	8.5%
66	Arthritis	8.5%
67	Bursitis	8.5%
68	Joint Instability	8.5%
69	Metatarsalgia	8.5%
70	Myofascial Pain Syndromes	8.5%
71	Rhabdomyolysis	8.5%
72	Synovitis	8.5%
73	Joint laxity	8.5%
74	Polyarthritis	8.5%
75	Frozen shoulder	8.5%
76	Patellofemoral Pain Syndrome	8.5%
77	Eosinophilic Granuloma	8.2%
78	Goldenhar Syndrome	8.1%
79	Mandibulofacial Dysostosis	8.1%
80	Tuberculosis, Spinal	7.7%
81	Basal Cell Nevus Syndrome	7.5%
82	Osteoarthritis, Spine	7.4%
83	Acrocephalosyndactylia	7.4%
84	Acromegaly	7.3%
85	Joint Tuberculosis	7.3%
86	Tuberculosis, Osteoarticular	7.3%
87	Bone Tuberculosis	7.3%
88	Antley-Bixler Syndrome Phenotype	7.3%
89	Spondylolisthesis	7.2%
90	Rubinstein-Taybi Syndrome	7%
91	Spondylarthropathies	7%
92	Poland Syndrome	6.8%
93	Rheumatic Fever	6.7%
94	Ankylosing spondylitis	6.6%
95	Cockayne Syndrome	6.6%
96	Hip Contracture	6.6%
97	Periarthritis	6.6%
98	Osteoporosis, Postmenopausal	6.5%
99	Gout	6.1%
100	Ischemic contracture	6%
101	Rickets	5.9%
102	Compartment syndromes	5.7%
103	Maxillary Diseases	5.7%
104	Tendinitis	5.7%
105	Tendinopathy	5.7%
106	Temporomandibular Joint Disorders	5.7%
107	Hemarthrosis	5.6%
108	Myositis	5.6%
109	Tietze's Syndrome	5.6%
110	Limb Deformities, Congenital	5.6%
111	Isaacs syndrome	5.6%
112	Craniofacial Abnormalities	5.6%
113	Myotonic Disorders	5.6%
114	Rheumatoid Arthritis	5.4%
115	Juvenile arthritis	5.4%
116	Osteoarthritis, Knee	5.4%
117	Arthritis, Psoriatic	5.3%
118	Bunion	4.9%
119	Fibrodysplasia Ossificans Progressiva	4.9%
120	Myoglobinuria	4.9%
121	Myositis Ossificans	4.9%
122	Pseudohypoparathyroidism	4.9%
123	Tenosynovitis	4.9%
124	Sacroiliitis	4.9%
125	Talipes	4.9%
126	Mastoiditis	4.8%
127	Petrositis	4.8%
128	Arthritis, Reactive	4.7%
129	Temporomandibular Joint Dysfunction Syndrome	4.5%
130	Medial Tibial Stress Syndrome	4.3%
131	Mitochondrial Myopathies	4.2%
132	Muscle Cramp	4.2%
133	Eosinophilia-Myalgia Syndrome	4.2%
134	Gastroschisis	4.2%
135	Muscle Rigidity	4.1%
136	Muscle Spasticity	4.1%
137	Cogwheel Rigidity	4.1%
138	Nuchal Rigidity	4.1%
139	Rheumatoid Nodule	4.1%
140	Osteomalacia	3.8%
141	Arthritis, Gouty	3.8%
142	Chronic Fatigue Syndrome	3.5%
143	Palatal Neoplasms	3.5%
144	Nail-Patella Syndrome	3.4%
145	Giant Cell Epulis	3.4%
146	Muscle Weakness	3.4%
147	Arthritis, Infectious	3.4%
148	Congenital clubfoot	3.4%
149	Vertical Talus	3.4%
150	Musculoskeletal Pain	3.3%
151	Jaw Abnormalities	3.3%
152	Familial Periodic Paralysis	3.3%
153	Anterior Compartment Syndrome	3.3%
154	Enthesopathy	3.3%
155	Arthritis, Experimental	3.3%
156	Abdominal Compartment Syndrome	3.3%
157	Arthralgia	3.3%
158	Polyarthralgia	3.3%
159	Felty Syndrome	3.3%
160	Amelia	3.3%
161	Arachnodactyly	3.3%
162	Ectromelia	3.3%
163	Hemimelia	3.3%
164	Phocomelia	3.3%
165	Sirenomelia	3.3%
166	Polymyositis	3.3%
167	Polydactyly	3.3%
168	Brachydactyly	3.3%
169	Plagiocephaly	3.3%
170	Lower Extremity Deformities, Congenital	3.3%
171	Upper Extremity Deformities, Congenital	3.3%
172	Laryngomalacia	2.9%
173	Myalgia	2.7%
174	Rheumatoid Vasculitis	2.7%
175	Prognathism	2.7%
176	Hip Dislocation	2.6%
177	Shoulder Dislocation	2.6%
178	Hip Dysplasia	2.6%
179	Nose Neoplasms	2.5%
180	Muscular Dystrophy	2.5%
181	Orbital Myositis	2.5%
182	Dupuytren Contracture	2.5%
183	Pyomyositis	2.5%
184	Renal Osteodystrophy	2.4%
185	Renal rickets	2.4%
186	Sicca Syndrome	2.3%
187	Sjogren's Syndrome	2.3%
188	Micrognathism	2.1%
189	Pierre Robin Syndrome	2.1%
190	Myotonic Dystrophy	2%
191	Maxillofacial Abnormalities	2%
192	Myotonia Congenita	2%
193	Bronchomalacia	2%
194	Tracheomalacia	2%
195	Microcephaly	1.9%
196	Macrocephaly	1.9%
197	Hypokalemic periodic paralysis	1.9%
198	Shoulder Pain	1.9%
199	Retrognathia	1.8%
200	Mitochondrial Encephalomyopathies	1.6%
201	Welander Distal Myopathy	1.6%
202	Cleft Palate	1.5%
203	Noonan Syndrome	1.4%
204	Dermatomyositis	1.3%
205	Muscular Dystrophy, Duchenne	1.3%
206	Porencephaly	1.3%
207	Holoprosencephaly	1.2%
208	Familial Hypophosphatemic Rickets	1.1%
209	Radicular Cyst	0.8%
210	MELAS Syndrome	0.6%
211	Kearns-Sayre syndrome	0.6%

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