MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Encephalomalacia

(UMLS:C0014068)

Definition:: Softening or loss of brain tissue following CEREBRAL INFARCTION; cerebral ischemia (see BRAIN ISCHEMIA), infection, CRANIOCEREBRAL TRAUMA, or other injury. The term is often used during gross pathologic inspection to describe blurred cortical margins and decreased consistency of brain tissue following infarction. Multicystic encephalomalacia refers to the formation of multiple cystic cavities of various sizes in the cerebral cortex of neonates and infants following injury, most notably perinatal hypoxia-ischemic events. (From Davis et al., Textbook of Neuropathology, 2nd ed, p665; J Neuropathol Exp Neurol, 1995 Mar;54(2):268-75)
UMLS ID:: C0014068
MeSH ID:: D004678

Classification:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.461

Synonym(s)

Encephalomalacia

Cerebral softening

ENCEPHALOMALACIA

cerebromalacia

encephalomalacia

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	rofecoxib	FAERS: 22		OFFSIDES US FAERS
2	NuvaRing	FAERS: 14		OFFSIDES US FAERS
3	Warfarin	FAERS: 8		US FAERS
4	Temozolomide	FAERS: 7		OFFSIDES US FAERS
5	Gabapentin	FAERS: 5		US FAERS
6	Phentermine	FAERS: 4		US FAERS
7	Rosiglitazone	FAERS: 4		US FAERS
8	Zoledronic Acid	FAERS: 4		US FAERS
9	Tacrolimus	FAERS: 3		US FAERS
10	Teriparatide	FAERS: 3		US FAERS
11	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 2		US FAERS
12	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 2		US FAERS
13	Acetaminophen	FAERS: 2		US FAERS
14	Acyclovir	FAERS: 2		US FAERS
15	Citalopram	FAERS: 2		US FAERS
16	Ortho Evra	FAERS: 2		US FAERS
17	Phentermine	FAERS: 2		US FAERS
18	Phenytoin	FAERS: 2		US FAERS
19	Sumatriptan	FAERS: 2		US FAERS
20	efavirenz	FAERS: 2		OFFSIDES US FAERS
21	eletriptan	FAERS: 2		US FAERS
22	Baclofen	FAERS: 1		US FAERS
23	Ciprofloxacin	FAERS: 1		US FAERS
24	Crizotinib	FAERS: 1		US FAERS
25	Dabigatran	FAERS: 1		US FAERS
26	Docetaxel	FAERS: 1		US FAERS
27	Donepezil	FAERS: 1		US FAERS
28	Estradiol	FAERS: 1		US FAERS
29	Fingolimod Hydrochloride	FAERS: 1		US FAERS
30	Isotretinoin	FAERS: 1		US FAERS
31	Ketamine	FAERS: 1		US FAERS
32	Letrozole	FAERS: 1		US FAERS
33	Levetiracetam	FAERS: 1		US FAERS
34	Lorazepam	FAERS: 1		OFFSIDES US FAERS
35	Olmesartan Medoxomil	FAERS: 1		US FAERS
36	Ondansetron	FAERS: 1		US FAERS
37	Paroxetine	FAERS: 1		US FAERS
38	Quetiapine Fumarate	FAERS: 1		US FAERS
39	Sertraline	FAERS: 1		US FAERS
40	Thyroxine	FAERS: 1		US FAERS
41	Warfarin	FAERS: 1		US FAERS
42	carbidopa, levodopa drug combination	FAERS: 1		US FAERS
43	ceritinib	FAERS: 1		US FAERS
44	fludarabine	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
45	Albuterol			OFFSIDES
46	Alprazolam			OFFSIDES
47	Amisulpride			OFFSIDES
48	Aspirin			OFFSIDES
49	Beclomethasone			OFFSIDES
50	Carnitine			OFFSIDES
51	Chlorhexidine			OFFSIDES
52	Cocaine		8515225	CTD
53	Deferasirox			OFFSIDES
54	Doxorubicin		28815802	CTD
55	Dutasteride			OFFSIDES
56	Ellagic Acid		28815802	CTD
57	Erlotinib Hydrochloride			OFFSIDES
58	Erlotinib Hydrochloride			OFFSIDES
59	Estramustine phosphate			OFFSIDES
60	Estramustine			OFFSIDES
61	Fluvastatin			OFFSIDES
62	Fondaparinux			OFFSIDES
63	Fulvestrant			OFFSIDES
64	Gadolinium			OFFSIDES
65	Labetalol			OFFSIDES
66	Lacosamide			OFFSIDES
67	Lenalidomide			OFFSIDES
68	Lisinopril			OFFSIDES
69	Lithium Carbonate			OFFSIDES
70	Lithium			OFFSIDES
71	Meperidine			OFFSIDES
72	Metformin			OFFSIDES
73	Methocarbamol			OFFSIDES
74	Modafinil			OFFSIDES
75	Mupirocin			OFFSIDES
76	Nortriptyline			OFFSIDES
77	Octreotide			OFFSIDES
78	Omeprazole			OFFSIDES
79	Pamidronate			OFFSIDES
80	Penicillin V			OFFSIDES
81	Pyridoxine			OFFSIDES
82	Quinidine			OFFSIDES
83	Rotenone		30222980	CTD
84	Selenium			OFFSIDES
85	Sevelamer			OFFSIDES
86	Sevelamer			OFFSIDES
87	Sodium Citrate			OFFSIDES
88	Spironolactone			OFFSIDES
89	Temazepam			OFFSIDES
90	Terazosin			OFFSIDES
91	Tranexamic Acid			OFFSIDES
92	Tretinoin			OFFSIDES
93	Triamterene			OFFSIDES
94	Vancomycin			OFFSIDES
95	Venlafaxine Hydrochloride			OFFSIDES
96	azelastine			OFFSIDES
97	bicalutamide			OFFSIDES
98	butalbital			OFFSIDES
99	calcium acetate			OFFSIDES
100	carbidopa, levodopa drug combination			OFFSIDES
101	chlorhexidine gluconate			OFFSIDES
102	desloratadine			OFFSIDES
103	entacapone			OFFSIDES
104	gadoversetamide			OFFSIDES
105	montelukast		30222980	CTD
106	naringin		26120027	CTD
107	oxybutynin			OFFSIDES
108	rosmarinic acid		28815802	CTD
109	trandolapril			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Akinetic Mutism	46.7%
2	Anoxic Encephalopathy	46.7%
3	Basal Ganglia Diseases	46.7%
4	Brain Damage, Chronic	46.7%
5	Cerebellar Diseases	46.7%
6	Encephalitis	46.7%
7	Epilepsy	46.7%
8	Hydrocephalus	46.7%
9	Congenital Hydrocephalus	46.7%
10	Hypothalamic Diseases	46.7%
11	Thalamic Diseases	46.7%
12	Intracranial Hypertension	46.7%
13	Aura	46.7%
14	Leukoencephalopathy	46.7%
15	Neuroaxonal Dystrophies	46.7%
16	Headache Disorders	46.7%
17	Intracranial Hypotension	46.7%
18	Brain Edema	46.7%
19	Brain Hypoxia	46.7%
20	Aqueductal Stenosis	46.7%
21	Posterior Leukoencephalopathy Syndrome	41.6%
22	Posterior reversible encephalopathy syndrome	41.6%
23	Subdural Effusion	40.7%
24	Myoclonic Epilepsy	37.6%
25	Epilepsy, Temporal Lobe	37.6%
26	Epilepsy, Rolandic	37.6%
27	Benign Rolandic Epilepsy	37.6%
28	Parkinsonian Disorders	36.3%
29	Meningoencephalitis	35.5%
30	Cerebral Palsy	34.4%
31	Epilepsies, Partial	34.4%
32	Epilepsy, Generalized	34.4%
33	Pseudotumor Cerebri	34.4%
34	Hypertensive Encephalopathy	34.4%
35	Simple Partial Seizures	34.4%
36	Epilepsy, Reflex	34.4%
37	Basal Ganglia Cerebrovascular Disease	34.4%
38	Headache Disorders, Primary	34.4%
39	Headache Disorders, Secondary	34.4%
40	Medication overuse headache	34.4%
41	Encephalomyelitis	34.1%
42	Juvenile Myoclonic Epilepsy	33.7%
43	Myoclonic Epilepsies, Progressive	33.7%
44	Meige Syndrome	32.6%
45	Cerebral Ventriculitis	32.6%
46	Dandy-Walker Syndrome	32%
47	Brain Diseases, Metabolic	31.8%
48	Cerebrovascular Disorders	31.8%
49	Cerebrovascular Insufficiency	31.8%
50	Dementia	31.8%
51	Dementia, Vascular	31.8%
52	Vascular Headaches	31.4%
53	Hypoxia-Ischemia, Brain	31.2%
54	Meningitis	31%
55	Movement Disorders	31%
56	Pachymeningitis	31%
57	Spinal Cord Diseases	31%
58	Marchiafava-Bignami Disease	30.3%
59	Lewy Body Disease	29.5%
60	Epilepsy, Post-Traumatic	29.2%
61	Multiple System Atrophy	28.9%
62	Post-Traumatic Headache	28.5%
63	Tension Headache	28.5%
64	Epilepsy, Complex Partial	28.5%
65	Migraine Disorders	28.5%
66	Abdominal Migraine	28.5%
67	Status Migrainosus	28.5%
68	Cervicogenic Headache	28.5%
69	Pneumocephalus	27.8%
70	Parkinson Disease	27%
71	Brain Abscess	26.8%
72	Myelitis	26.7%
73	Brain Injuries	26.7%
74	Brain Neoplasms	26.4%
75	Cerebellar Neoplasms	26.3%
76	Cluster Headache	25.5%
77	Migraine with Aura	25.5%
78	Familial Hemiplegic Migraine	25.5%
79	Chronic Paroxysmal Hemicrania	25.5%
80	SUNCT Syndrome	25.5%
81	Paroxysmal Hemicrania	25.5%
82	Brain Death	24.8%
83	Pituitary Diseases	24.7%
84	Creutzfeldt-Jakob disease	24.6%
85	Basal Ganglia Hemorrhage	23.2%
86	Carotid Artery Diseases	23.1%
87	Brain Ischemia	23.1%
88	Cerebrovascular accident	23.1%
89	Kluver-Bucy Syndrome	23.1%
90	Vasospasm, Intracranial	23.1%
91	Intracranial Arterial Diseases	23.1%
92	Pituitary Apoplexy	23%
93	Neuroleptic Malignant Syndrome	22.7%
94	Myelinolysis, Central Pontine	22.7%
95	Brain Infarction	22.6%
96	Dystonia Musculorum Deformans	22.4%
97	Huntington Disease	22%
98	Central Nervous System Infection	22%
99	Lafora Disease	22%
100	Unverricht-Lundborg Syndrome	22%
101	Striatonigral Degeneration	21.8%
102	Ocular Motility Disorders	21.8%
103	Cyclophoria	21.8%
104	Epidural Abscess	21.7%
105	Putaminal Hemorrhage	21%
106	Presenile dementia	20.7%
107	Senile dementia	20.7%
108	Infarction, Middle Cerebral Artery	20.6%
109	Infarction, Anterior Cerebral Artery	20.6%
110	Infarction, Posterior Cerebral Artery	20.6%
111	Amblyopia	20.6%
112	Prion Diseases	20.5%
113	Cerebral Infarction	20.1%
114	Brain Stem Infarctions	20.1%
115	Arachnoiditis	20%
116	Aseptic Meningitis	20%
117	Syringomyelia	20%
118	Essential Tremor	20%
119	Familial Tremor	20%
120	Pneumorrhachis	20%
121	Writer's Cramp	20%
122	Empty Sella Syndrome	19.6%
123	Hyperpituitarism	19.6%
124	Hypopituitarism	19.6%
125	Hypophysitis	19.6%
126	Brain Injuries, Diffuse	19.5%
127	Traumatic Brain Injury	19.5%
128	Cerebellar Ataxia	19.4%
129	Supratentorial Neoplasms	19.4%
130	MPTP Poisoning	19.3%
131	Pituitary Adenoma	19.3%
132	Pituitary Neoplasms	19.3%
133	Leukoencephalopathy, Progressive Multifocal	19.3%
134	Cerebral Arterial Diseases	18.9%
135	Vertebrobasilar Insufficiency	18.9%
136	Lateral Medullary Syndrome	18.9%
137	Basilar Artery Stenosis	18.9%
138	Vertebral Artery Stenosis	18.9%
139	Intracranial Hemorrhage, Hypertensive	18.9%
140	Transient Cerebral Ischemia	18.9%
141	Persistent Vegetative State	18.9%
142	Limbic Encephalitis	18.6%
143	Cranial nerve diseases	18.5%
144	Demyelinating Diseases	18.5%
145	Demyelination	18.5%
146	Neuromuscular Diseases	18.5%
147	Chronobiology Disorders	18.5%
148	Shy-Drager Syndrome	18.3%
149	Carotid Artery Injuries	18.1%
150	Moyamoya Disease	17.9%
151	Progressive supranuclear palsy	17.6%
152	Lupus Vasculitis, Central Nervous System	17.5%
153	Reye Syndrome	17.4%
154	Meningitis, Bacterial	17.4%
155	Meningitis, Fungal	17.4%
156	Brain Hemorrhage, Traumatic	17.2%
157	Intracranial Embolism and Thrombosis	17.2%
158	Hepatic Encephalopathy	17.2%
159	Hyperprolactinemia	17.2%
160	Leukoencephalitis, Acute Hemorrhagic	17%
161	Subclavian Steal Syndrome	16.9%
162	Pick Disease of the Brain	16.9%
163	Encephalomyelitis, Acute Disseminated	16.7%
164	Spinal Muscular Atrophy	16.7%
165	Progressive Muscular Atrophy	16.7%
166	Amnesia, Transient Global	16.6%
167	Paraneoplastic Cerebellar Degeneration	16.4%
168	Stiff-Person Syndrome	16.4%
169	Spinal Cord Injuries	16.1%
170	Diffuse Axonal Injury	16.1%
171	Brain Stem Neoplasms	16%
172	Friedreich Ataxia	16%
173	Poliomyelitis	15.9%
174	Asterixis	15.3%
175	Ballismus	15.3%
176	Toxoplasmosis, Cerebral	15.2%
177	Vasculitis, Central Nervous System	15.1%
178	Hepatolenticular Degeneration	14.9%
179	Canavan Disease	14.9%
180	Alexander Disease	14.9%
181	Choroid Plexus Papilloma	14.4%
182	Carotid Stenosis	14.3%
183	Intracranial Aneurysm	14.3%
184	Intracranial Arteriosclerosis	14.2%
185	Cerebral Atherosclerosis	14.2%
186	Subarachnoid Hemorrhage	14.2%
187	Cerebral Arteriosclerosis	14.2%
188	Cerebral Hemorrhage	14.2%
189	Cerebral Thrombosis	14.1%
190	Intracranial Embolism	14.1%
191	Intracranial Thrombosis	14.1%
192	Ophthalmoplegic Migraine	14%
193	Motor Neuron Disease	14%
194	Brain Diseases, Metabolic, Inborn	13.9%
195	Subarachnoid Hemorrhage, Traumatic	13.8%
196	Carotid Artery, Internal, Dissection	13.8%
197	Leukomalacia, Periventricular	13.8%
198	Central Nervous System Fungal Infections	13.6%
199	Conus Medullaris Syndrome	13.6%
200	Spinal Cord Vascular Diseases	13.6%
201	Subacute Combined Degeneration	13.5%
202	Amyotrophic Lateral Sclerosis	13.3%
203	Frontotemporal dementia	13.2%
204	Spinal Cord Neoplasms	13.2%
205	Miller Fisher Syndrome	13.2%
206	Mitochondrial Encephalomyopathies	13.1%
207	Brain Contusion	12.9%
208	Acromegaly	12.9%
209	Chronic Fatigue Syndrome	12.9%
210	Tuberculosis, Meningeal	12.8%
211	Trauma, Nervous System	12.8%
212	Subacute Sclerosing Panencephalitis	12.7%
213	Cerebral Amyloid Angiopathy	12.7%
214	Sinus Thrombosis, Intracranial	12.6%
215	Nervous System Neoplasms	12.2%
216	Neurologic Manifestations	12.2%
217	Neurotoxicity Syndromes	12.2%
218	MELAS Syndrome	12.1%
219	Cavernous Sinus Thrombosis	11.9%
220	Sagittal Sinus Thrombosis	11.9%
221	Vertebral Artery Dissection	11.7%
222	Wernicke Encephalopathy	11.5%
223	AIDS Dementia Complex	11.4%
224	Autonomic Dysreflexia	11.4%
225	Complex Regional Pain Syndromes	11.4%
226	Carotid Artery Thrombosis	11.3%
227	Auditory Perceptual Disorders	11.2%
228	Myelitis, Transverse	10.9%
229	Scrapie	10.9%
230	Central Cord Syndrome	10.9%
231	Adrenoleukodystrophy	10.8%
232	Meningitis, Cryptococcal	10.7%
233	Meningitis, Listeria	10.7%
234	Chorea	10.7%
235	Meningitis, Haemophilus	10.6%
236	Meningitis, Pneumococcal	10.6%
237	Brain Concussion	10.6%
238	Dysautonomia	10.3%
239	Vagus Nerve Disorder	10.3%
240	Glossopharyngeal Neuralgia	10.3%
241	Abducens Nerve Diseases	10.3%
242	Heavy Metal Poisoning, Nervous System	10.3%
243	Neuromuscular Junction Diseases	10.3%
244	Central Nervous System Bacterial Infections	10.3%
245	Tauopathies	10.3%
246	Trochlear Nerve Diseases	10.3%
247	Peripheral Nervous System Diseases	10.3%
248	West Nile Fever	10.2%
249	Polyradiculoneuropathy	10.2%
250	Polyradiculoneuritis	10.2%
251	Akathisia, Drug-Induced	10.1%
252	Ataxia Telangiectasia	10.1%
253	Kernicterus	10%
254	Alice in Wonderland Syndrome	10%
255	Spinal Cord Ischemia	9.9%
256	Torticollis	9.7%
257	Tuberculosis, Central Nervous System	9.7%
258	Restless Legs Syndrome	9.7%
259	Opsoclonus-Myoclonus Syndrome	9.6%
260	Nelson Syndrome	9.6%
261	Sleep Wake Disorders	9.3%
262	Dyskinesia, Drug-Induced	9.1%
263	Progressive bulbar palsy	8.9%
264	Bulbar palsy	8.9%
265	Giant Cell Arteritis	8.8%
266	Temporal Arteritis	8.8%
267	Hematoma, Subdural	8.6%
268	Hematoma, Epidural, Cranial	8.6%
269	Peripheral Nerve Injuries	8.6%
270	Prolactinoma	8.6%
271	Growth Hormone-Secreting Pituitary Adenoma	8.6%
272	Myasthenia Gravis	8.5%
273	Tardive Dyskinesia	8.5%
274	Causalgia	8.2%
275	Anterior Spinal Artery Syndrome	8.1%
276	Galactosemias	8.1%
277	Urea Cycle Disorders, Inborn	8.1%
278	Tyrosinemias	8.1%
279	Guillain-Barre Syndrome	7.9%
280	Fabry Disease	7.9%
281	Hematoma, Subdural, Intracranial	7.9%
282	Hematoma, Subdural, Chronic	7.9%
283	Hematoma, Subdural, Acute	7.9%
284	Reflex Sympathetic Dystrophy	7.7%
285	Nocturnal Myoclonus Syndrome	7.7%
286	Neuroaspergillosis	7.4%
287	Myopathy	7.3%
288	Optic Neuropathy	7.3%
289	Refsum Disease	7.3%
290	Olfactory Nerve Injuries	7.2%
291	Homocystinuria	7.1%
292	Leigh Disease	7.1%
293	Sleep Disorders, Circadian Rhythm	7%
294	Facial Nerve Diseases	7%
295	Craniocerebral Trauma	7%
296	Parasomnia	7%
297	Dyssomnias	7%
298	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	6.9%
299	Vestibulocochlear Nerve Diseases	6.8%
300	Decerebrate State	6.8%
301	Hemiparesis	6.8%
302	Hydranencephaly	6.8%
303	Meningism	6.8%
304	Neural Tube Defects	6.8%
305	Paresis	6.8%
306	Seizures	6.8%
307	Sensation Disorders	6.8%
308	Tethered Cord Syndrome	6.8%
309	Central Nervous System Neoplasms	6.8%
310	Complex partial seizures	6.8%
311	Iniencephaly	6.8%
312	Craniorachischisis	6.8%
313	Exencephaly	6.8%
314	Monoparesis	6.8%
315	Septo-Optic Dysplasia	6.8%
316	Cortical Dysplasia	6.8%
317	Neurogenic Inflammation	6.8%
318	Gait Disorders, Neurologic	6.8%
319	Neuromuscular Manifestations	6.8%
320	Malformations of Cortical Development	6.8%
321	Sweating, Gustatory	6.7%
322	Auriculotemporal Syndrome	6.7%
323	Botulism	6.7%
324	Central Nervous System Cysts	6.7%
325	Lambert-Eaton Myasthenic Syndrome	6.7%
326	Neuritis	6.7%
327	Polyneuritis	6.7%
328	Radiculitis	6.7%
329	Polyneuropathy	6.7%
330	Mononeuritis	6.7%
331	Mononeuropathies	6.7%
332	Brachial Plexus Neuropathies	6.7%
333	Radiculopathy	6.7%
334	Mononeuropathy Multiplex	6.7%
335	Nerve Root Compression	6.7%
336	Multiple Sclerosis	6.6%
337	Brachial Plexus Neuritis	6.5%
338	Neuralgic Amyotrophy	6.5%
339	Carbamoyl-Phosphate Synthase I Deficiency Disease	6.3%
340	Pseudorabies	6.3%
341	Toxoplasmosis, Congenital	6.2%
342	Malaria, Cerebral	6.2%
343	Neuromyelitis Optica	6.2%
344	Neurocysticercosis	6.1%
345	Facial Nerve Injuries	6%
346	Horner Syndrome	6%
347	Tarsal Tunnel Syndrome	5.9%
348	Cauda Equina Syndrome	5.9%
349	Menkes Kinky Hair Syndrome	5.9%
350	Neurosyphilis	5.8%
351	Acrodynia	5.7%
352	Glycogen storage disease type II	5.6%
353	Ophthalmoplegia	5.4%
354	External Ophthalmoplegia	5.4%
355	Pupil Disorders	5.4%
356	Neurobehavioral Manifestations	5.4%
357	Zellweger Syndrome	5.2%
358	Paraneoplastic Encephalomyelitis	5.2%
359	Charcot-Marie-Tooth Disease	5.1%
360	Myasthenia Gravis, Autoimmune, Experimental	5.1%
361	Coma, Post-Head Injury	5.1%
362	Uveomeningoencephalitic Syndrome	5.1%
363	Sturge-Weber Syndrome	5%
364	Vertigo	5%
365	Alcohol-Induced Disorders, Nervous System	5%
366	Jet Lag Syndrome	5%
367	Sciatic Neuropathy	4.9%
368	Ulnar Neuropathies	4.9%
369	Lesion of Sciatic Nerve	4.9%
370	Ulnar Neuritis	4.9%
371	Radial nerve compression	4.9%
372	Radial Tunnel Syndrome	4.9%
373	Peroneal Neuropathies	4.9%
374	Radial Neuropathy	4.9%
375	Median Neuropathy	4.9%
376	Sciatic Nerve Palsy	4.9%
377	Femoral Neuropathy	4.9%
378	Tibial Neuropathy	4.9%
379	Ulnar Nerve Palsy	4.9%
380	Postural Orthostatic Tachycardia Syndrome	4.9%
381	Radial nerve palsy	4.9%
382	Multiple Sclerosis, Chronic Progressive	4.9%
383	Multiple Sclerosis, Relapsing-Remitting	4.9%
384	Lyme Neuroborreliosis	4.9%
385	Gaucher Disease	4.7%
386	Myotonia Congenita	4.6%
387	Waterhouse-Friderichsen Syndrome	4.6%
388	Cerebrospinal Fluid Otorrhea	4.6%
389	Cerebrospinal Fluid Rhinorrhea	4.6%
390	Neuritis, Autoimmune, Experimental	4.6%
391	Gait Ataxia	4.6%
392	Myositis	4.5%
393	Optic Atrophy	4.5%
394	Optic Neuritis	4.5%
395	Papilledema	4.5%
396	Strabismus	4.5%
397	Tolosa-Hunt Syndrome	4.5%
398	Isaacs syndrome	4.5%
399	Arsenic Poisoning	4.5%
400	Myotonic Disorders	4.5%
401	Myasthenic Syndromes, Congenital	4.5%
402	Vocal Cord Paralysis	4.5%
403	Carpal Tunnel Syndrome	4.5%
404	Tay-Sachs Disease	4.5%
405	neurofibroma	4.5%
406	Diabetic Neuropathies	4.4%
407	Facial Injuries	4.4%
408	Facial Neuralgia	4.4%
409	Diabetic Amyotrophy	4.4%
410	Diabetic Autonomic Neuropathy	4.4%
411	Sleep Talking	4.4%
412	Manganese Poisoning	4.4%
413	Sleep Disorders, Intrinsic	4.4%
414	Orthostatic intolerance	4.4%
415	Sciatica	4.4%
416	Tuberous Sclerosis	4.4%
417	Anosmia	4.4%
418	Ataxia	4.4%
419	Athetosis	4.4%
420	Catalepsy	4.4%
421	Dystonia	4.4%
422	Hemiplegia	4.4%
423	Locked-In Syndrome	4.4%
424	Meningeal Neoplasms	4.4%
425	Meningomyelocele	4.4%
426	Muscle Hypertonia	4.4%
427	Muscle hypotonia	4.4%
428	Myoclonus	4.4%
429	Myotonia	4.4%
430	Neuralgia	4.4%
431	Paraplegia	4.4%
432	Pseudobulbar Palsy	4.4%
433	Quadriplegia	4.4%
434	Spasm	4.4%
435	Spastic Paraplegia	4.4%
436	Status Epilepticus	4.4%
437	Taste Disorders	4.4%
438	Tremor	4.4%
439	Spina Bifida	4.4%
440	Monoplegia	4.4%
441	Hypokinesia	4.4%
442	Paraparesis	4.4%
443	Bradykinesia	4.4%
444	Waxy flexibility	4.4%
445	Action Tremor	4.4%
446	Resting Tremor	4.4%
447	Dysosmia	4.4%
448	Quadriparesis	4.4%
449	Mercury Poisoning, Nervous System	4.4%
450	Olfaction Disorders	4.4%
451	Myokymia	4.4%
452	Lead Poisoning, Nervous System	4.4%
453	Vestibular Neuronitis	4.4%
454	Somatosensory Disorders	4.4%
455	Neuropathic pain	4.4%
456	Hyperkinesia	4.4%
457	Intention tremor	4.4%
458	Voice Disorders	4.2%
459	Voice Disturbance	4.2%
460	Niemann-Pick Disease, Type C	4.1%
461	Polyradiculopathy	4.1%
462	Smith-Magenis syndrome	4.1%
463	Cubital Tunnel Syndrome	4%
464	Dural Arteriovenous Fistula	4%
465	Myotonic Dystrophy	3.9%
466	Akathisia	3.8%
467	Restlessness	3.8%
468	Psychomotor Agitation	3.8%
469	Alcohol Withdrawal Seizures	3.7%
470	Hand-Arm Vibration Syndrome	3.6%
471	Gait Apraxia	3.5%
472	Vision Disorders	3.5%
473	Metamorphopsia	3.5%
474	Visual Impairment	3.5%
475	Fibromyalgia	3.4%
476	Optic Neuropathy, Ischemic	3.4%
477	Anterior Ischemic Optic Neuropathy	3.4%
478	Medial Tibial Stress Syndrome	3.4%
479	Facial Hemiatrophy	3.4%
480	Melkersson-Rosenthal Syndrome	3.4%
481	Mitochondrial Myopathies	3.4%
482	Thoracic Outlet Syndrome	3.4%
483	Anisocoria	3.4%
484	Confusion	3.4%
485	Facial paralysis	3.4%
486	Lethargy	3.4%
487	Memory Disorders	3.4%
488	Muscle Cramp	3.4%
489	Perceptual Disorders	3.4%
490	Psychomotor Disorders	3.4%
491	Tonic Pupil	3.4%
492	Eosinophilia-Myalgia Syndrome	3.4%
493	Anhedonia	3.4%
494	Disorientation	3.4%
495	Facial Paresis	3.4%
496	Memory Loss	3.4%
497	Hemisensory Neglect	3.4%
498	Dysacusis	3.4%
499	Optic Nerve Glioma	3.4%
500	Sleep Bruxism	3.3%
501	Reflex, Abnormal	3.3%
502	Hyporeflexia	3.3%
503	Hyperreflexia	3.3%
504	Anencephaly	3.3%
505	Meningocele	3.3%
506	Muscular Atrophy	3.3%
507	Respiratory Paralysis	3.3%
508	Encephalocele	3.3%
509	Esotropia	3.3%
510	Exotropia	3.3%
511	Hypotension, Orthostatic	3.3%
512	Sleep Apnea Syndromes	3.3%
513	Polymyositis	3.3%
514	Post-Exercise Hypotension	3.3%
515	Tetany	3.3%
516	Disorders of Excessive Somnolence	3.3%
517	Sleep Initiation and Maintenance Disorders	3.3%
518	Night Terrors	3.3%
519	Somnambulism	3.3%
520	Trigeminal Nerve Disorder	3.3%
521	Transient Insomnia	3.3%
522	Sleep Paralysis	3.3%
523	Chronic Insomnia	3.3%
524	REM Sleep Behavior Disorder	3.3%
525	Hypersomnia	3.3%
526	Dermal Sinus	3.2%
527	Dysgeusia	3.2%
528	Formication	3.2%
529	Hyperalgesia	3.2%
530	Hyperesthesia	3.2%
531	Hypesthesia	3.2%
532	Language Disorders	3.2%
533	Numbness	3.2%
534	Paresthesia	3.2%
535	Paraparesis, Spastic	3.2%
536	Spina Bifida Cystica	3.2%
537	Trismus	3.2%
538	Spina Bifida Occulta	3.2%
539	Epilepsia Partialis Continua	3.2%
540	Hypogeusia	3.2%
541	Meningeal Carcinomatosis	3.2%
542	Brown-Sequard Syndrome	3.2%
543	Lissencephaly	3.2%
544	Polymicrogyria	3.2%
545	Pachygyria	3.2%
546	Schizencephaly	3.2%
547	Lockjaw	3.2%
548	Allodynia	3.2%
549	Lead Poisoning, Nervous System, Childhood	3.2%
550	Lead Poisoning, Nervous System, Adult	3.2%
551	Periventricular Nodular Heterotopia	3.2%
552	Ageusia	3.2%
553	Alstrom Syndrome	3.1%
554	Classical Lissencephalies and Subcortical Band Heterotopias	2.9%
555	Amyloid Neuropathies, Familial	2.8%
556	Duane Retraction Syndrome	2.7%
557	Consciousness Disorders	2.7%
558	Mental Retardation	2.7%
559	Muscle Weakness	2.7%
560	Depressed Level of Consciousness	2.7%
561	Mental deficiency	2.7%
562	Intellectual Disability	2.7%
563	Mobius Syndrome	2.7%
564	Bell Palsy	2.7%
565	Sleep Apnea, Obstructive	2.7%
566	Sleep Apnea, Central	2.7%
567	Narcolepsy	2.7%
568	Trigeminal Neuralgia	2.7%
569	Kleine-Levin Syndrome	2.7%
570	Catatonia	2.7%
571	Agraphia	2.7%
572	Alexia	2.7%
573	Anomia	2.7%
574	Cluttering	2.7%
575	Language Development Disorders	2.7%
576	Speech Disorders	2.7%
577	Syncope	2.7%
578	Stupor	2.7%
579	Dysgraphia	2.7%
580	Dyslexia	2.7%
581	Presyncope	2.7%
582	Dyslalia	2.7%
583	Herpes Zoster Oticus	2.7%
584	Familial Periodic Paralysis	2.7%
585	Aphonia	2.6%
586	Sleep Deprivation	2.6%
587	Dysphonia	2.6%
588	Acoustic Neuroma	2.6%
589	Eye Injuries	2.6%
590	Neurofibrosarcoma	2.5%
591	Muscular Dystrophy	2.5%
592	Congenital nystagmus	2.5%
593	Orbital Myositis	2.5%
594	Diplopia	2.5%
595	Muscle Rigidity	2.5%
596	Muscle Spasticity	2.5%
597	Scotoma	2.5%
598	Photophobia	2.5%
599	Cogwheel Rigidity	2.5%
600	Hemifacial Spasm	2.5%
601	Amaurosis	2.5%
602	Blindness	2.5%
603	Nuchal Rigidity	2.5%
604	Pyomyositis	2.5%
605	Agnosia	2.4%
606	Apraxias	2.4%
607	Hallucinations	2.4%
608	Hemianopsia	2.4%
609	Hyperacusis	2.4%
610	Tinnitus	2.4%
611	Visual Agnosia	2.4%
612	Anosognosia	2.4%
613	Wernicke-Korsakoff Syndrome	2.4%
614	Phonophobia	2.4%
615	Hearing Loss	2.4%
616	Sarcopenia	2.4%
617	Cataplexy	2.4%
618	Aphasia	2.4%
619	Articulation Disorders	2.4%
620	Echolalia	2.4%
621	Stuttering	2.4%
622	Dysphasia	2.4%
623	Dysarthria	2.3%
624	Optic Atrophy, Hereditary, Leber	2.2%
625	Myalgia	2.2%
626	Kearns-Sayre syndrome	2.2%
627	Neuronal Ceroid-Lipofuscinoses	2.2%
628	Eye Burns	2.1%
629	Welander Distal Myopathy	2%
630	Amaurosis Fugax	2%
631	Blindness, Cortical	2%
632	Dyscalculia	2%
633	Rett Syndrome	2%
634	Deafness	2%
635	Hearing Loss, Sudden	2%
636	Gerstmann Syndrome	2%
637	Hearing Loss, Bilateral	2%
638	Hearing Loss, High-Frequency	2%
639	Hearing Loss, Mixed Conductive-Sensorineural	2%
640	Prosopagnosia	2%
641	Apraxia, Ideomotor	2%
642	Charles Bonnet Syndrome	2%
643	Hearing Loss, Unilateral	2%
644	Complete Hearing Loss	2%
645	Alien Hand Syndrome	2%
646	Deaf Mutism	2%
647	Amnesia	2%
648	Delirium	2%
649	Dissociative Amnesia	2%
650	Color blindness	2%
651	Global Amnesia	2%
652	Cri-du-Chat Syndrome	2%
653	Down Syndrome	2%
654	Trisomy 21	2%
655	POEMS Syndrome	2%
656	Meningioma	2%
657	Williams Syndrome	2%
658	Microcephaly	2%
659	Macrocephaly	2%
660	Hypokalemic periodic paralysis	1.9%
661	Porencephaly	1.9%
662	Aicardi's syndrome	1.9%
663	Hoarseness	1.9%
664	Cockayne Syndrome	1.9%
665	Alcohol Withdrawal Delirium	1.9%
666	Mutism	1.8%
667	Selective Mutism	1.8%
668	Alexia, Pure	1.7%
669	Dermatomyositis	1.7%
670	Corneal Scar	1.7%
671	Holoprosencephaly	1.7%
672	Prader-Willi Syndrome	1.6%
673	Muscular Dystrophy, Duchenne	1.6%
674	Phantom pain	1.6%
675	Phantom Limb Pain	1.6%
676	Retrograde amnesia	1.6%
677	Amnesia, Anterograde	1.6%
678	Corneal Perforation	1.5%
679	Fragile X Syndrome	1.3%
680	Rubinstein-Taybi Syndrome	1.2%
681	Mucopolysaccharidosis II	0.9%

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