MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Craniosynostosis

(UMLS:C0010278)

Definition:: Premature closure of one or more CRANIAL SUTURES. It often results in plagiocephaly. Craniosynostoses that involve multiple sutures are sometimes associated with congenital syndromes such as ACROCEPHALOSYNDACTYLIA; and CRANIOFACIAL DYSOSTOSIS.
UMLS ID:: C0010278
MeSH ID:: D003398

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.099.370.894.232|C05.660.207.240|C05.660.906.364

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.621.207.240|C16.131.621.906.364

Synonym(s)

Craniosynostosis

CRANIOSYNOSTOSIS

CSO - Craniosynostosis

Congenital ossification of cranial sutures

Congenital ossification of sutures

Congenital ossification of sutures of skull

Cranial suture synostosis

Craniostenosis

Craniostosis

10.

Craniosynostoses

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Paroxetine	FAERS: 113	US FAERS
2	Fluoxetine	FAERS: 88	US FAERS
3	Sertraline	FAERS: 65	US FAERS
4	Methotrexate	FAERS: 33	US FAERS
5	Citalopram	FAERS: 28	US FAERS
6	Valproic Acid	FAERS: 23	US FAERS
7	Ondansetron	FAERS: 22	US FAERS
8	Valproic Acid	FAERS: 18	US FAERS
9	Valproic Acid	FAERS: 9	US FAERS
10	Nortriptyline	FAERS: 6	US FAERS
11	Citalopram	FAERS: 5	US FAERS
12	Imatinib Mesylate	FAERS: 5	US FAERS
13	Fluconazole	FAERS: 4 Canada Vigilance: 1	Canada Vigilance US FAERS
14	Lamotrigine	FAERS: 4	US FAERS
15	Topiramate	FAERS: 4	US FAERS
16	Naproxen	FAERS: 3	US FAERS
17	Clotrimazole	FAERS: 2	OFFSIDES US FAERS
18	Everolimus	FAERS: 2	US FAERS
19	Fluoxetine	FAERS: 2	US FAERS
20	Fluvoxamine	FAERS: 2	US FAERS
21	Letrozole	FAERS: 2	OFFSIDES US FAERS
22	Metformin	FAERS: 2	US FAERS
23	Methadone	FAERS: 2	US FAERS
24	Metronidazole	FAERS: 2	US FAERS
25	Mycophenolic Acid	FAERS: 2	US FAERS
26	Nortriptyline	FAERS: 2	OFFSIDES US FAERS
27	Paroxetine	FAERS: 2 Canada Vigilance: 5	Canada Vigilance US FAERS
28	Venlafaxine Hydrochloride	FAERS: 2	US FAERS
29	asfotase alfa	FAERS: 2	US FAERS
30	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 1	US FAERS
31	Atorvastatin	FAERS: 1	US FAERS
32	Carbamazepine	FAERS: 1	US FAERS
33	Cephalexin	FAERS: 1	US FAERS
34	Clozapine	FAERS: 1	US FAERS
35	Colchicine	FAERS: 1	US FAERS
36	Glatiramer Acetate	FAERS: 1	US FAERS
37	Imatinib Mesylate	FAERS: 1	US FAERS
38	Leflunomide	FAERS: 1	US FAERS
39	Mercaptopurine	FAERS: 1	US FAERS
40	Methimazole	FAERS: 1	US FAERS
41	Methotrexate	FAERS: 1	US FAERS
42	Methylphenidate	FAERS: 1	US FAERS
43	Miconazole	FAERS: 1	US FAERS
44	Norgestrel	FAERS: 1	US FAERS
45	Ondansetron	FAERS: 1	US FAERS
46	Phenytoin	FAERS: 1	US FAERS
47	Sertraline	FAERS: 1	OFFSIDES US FAERS
48	Thyroxine	FAERS: 1	US FAERS
49	dicyclomine, doxylamine, pyridoxine drug combination	FAERS: 1	US FAERS
50	norgestimate, ethinyl estradiol drug combination	FAERS: 1	US FAERS
51	reviparin	FAERS: 1	US FAERS
52	tioconazole	FAERS: 1	US FAERS
53	Bupropion		OFFSIDES
54	Clomiphene		OFFSIDES
55	Dapsone		OFFSIDES
56	Meperidine		OFFSIDES
57	Methyldopa		OFFSIDES
58	Nevirapine		OFFSIDES
59	Nitrofurantoin		OFFSIDES
60	Pentamidine		OFFSIDES
61	Pentamidine		OFFSIDES
62	Phenazopyridine		OFFSIDES
63	Sulfamethoxazole		OFFSIDES
64	Sulfate		OFFSIDES
65	Thyroxine		SIDER
66	alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination		OFFSIDES
67	dexamethasone acetate		OFFSIDES
68	efavirenz		OFFSIDES
69	lamivudine, zidovudine drug combination		OFFSIDES
70	trimethobenzamide		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Syndactyly	57.7%
2	Craniofacial Dysostosis	46.8%
3	Platybasia	46.4%
4	Klippel-Feil Syndrome	45.8%
5	Pectus excavatum	44.7%
6	Arthrogryposis	43.2%
7	Rubinstein-Taybi Syndrome	42.8%
8	Poland Syndrome	42.8%
9	Pectus carinatum	41.6%
10	Antley-Bixler Syndrome Phenotype	41.1%
11	Plagiocephaly	40.3%
12	Limb Deformities, Congenital	39%
13	Holoprosencephaly	38.4%
14	Acrocephalosyndactylia	38.4%
15	Maxillofacial Abnormalities	38.3%
16	Microcephaly	34.5%
17	Macrocephaly	34.5%
18	Gastroschisis	34%
19	Mandibulofacial Dysostosis	30.5%
20	Noonan Syndrome	29.5%
21	Jaw Abnormalities	27.9%
22	Goldenhar Syndrome	27.9%
23	Porencephaly	26.4%
24	Amelia	25.4%
25	Arachnodactyly	25.4%
26	Ectromelia	25.4%
27	Hemimelia	25.4%
28	Phocomelia	25.4%
29	Sirenomelia	25.4%
30	Polydactyly	25.4%
31	Brachydactyly	25.4%
32	Lower Extremity Deformities, Congenital	25.4%
33	Upper Extremity Deformities, Congenital	25.4%
34	Micrognathism	21.5%
35	Pierre Robin Syndrome	21.5%
36	Prognathism	20.9%
37	Craniofacial Abnormalities	20.6%
38	Synostosis	20.4%
39	Craniosynostosis	20.2%
40	Brachycephaly	20.2%
41	Osteoarthropathy, Secondary Hypertrophic	20%
42	Retrognathia	19.8%
43	Cleft Palate	19.8%
44	Talipes	19.7%
45	Laryngomalacia	19.7%
46	Marfan Syndrome	18.2%
47	Osteochondritis	17.5%
48	Beckwith-Wiedemann Syndrome	17.2%
49	Wolf-Hirschhorn Syndrome	17.2%
50	Gigantism	16.8%
51	Multiple Epiphyseal Dysplasia	16.8%
52	Osteochondrodysplasias	16.8%
53	Abnormalities, Drug-Induced	16.5%
54	Situs Inversus	16.5%
55	Nail-Patella Syndrome	16.5%
56	Aicardi's syndrome	16.3%
57	Congenital clubfoot	16.1%
58	Vertical Talus	16.1%
59	Fasciitis	16.1%
60	Foot Deformities	16.1%
61	Arthropathy	16.1%
62	Contracture	15.8%
63	Fasciitis, Plantar	15.8%
64	Smith-Magenis syndrome	15.5%
65	Cri-du-Chat Syndrome	15.3%
66	Down Syndrome	15.3%
67	Trisomy 21	15.3%
68	Dwarfism	15.1%
69	Eye Abnormalities	14.6%
70	Cardiovascular Abnormalities	14.6%
71	Skin Abnormalities	14.3%
72	Lymphatic Abnormalities	14.3%
73	Congenital Microtia	14.3%
74	Jaw Diseases	14.1%
75	Congenital diaphragmatic hernia	14.1%
76	Hyperostosis	14%
77	Osteitis	14%
78	Osteitis Deformans	14%
79	Osteochondrosis	14%
80	Spinal Diseases	14%
81	Bronchomalacia	14%
82	Tracheomalacia	14%
83	Cockayne Syndrome	13.9%
84	Cartilage Diseases	13.9%
85	Foot Diseases	13.9%
86	Myopathy	13.9%
87	Rheumatism	13.9%
88	Chondromalacia	13.9%
89	Ectodermal Dysplasia	13.8%
90	Aplasia Cutis Congenita	13.8%
91	Fibromyalgia	13.8%
92	Polymyalgia Rheumatica	13.8%
93	Prader-Willi Syndrome	13.7%
94	Metatarsalgia	13.7%
95	Gout	13.7%
96	Basal Cell Nevus Syndrome	13.3%
97	Urogenital Abnormalities	12.8%
98	Spinal Neoplasms	12.7%
99	Spondylitis	12.7%
100	Congenital Hypothyroidism	12.6%
101	Bone Diseases, Endocrine	12.4%
102	Anencephaly	12.3%
103	Bone Diseases, Infectious	12.2%
104	Bone neoplasms	12.2%
105	Osteopenia	12.2%
106	Kartagener Syndrome	12.1%
107	Osteoarthritis, Spine	12.1%
108	Bone Resorption	12.1%
109	Aseptic Necrosis of Bone	12.1%
110	Temporomandibular Joint Disorders	11.6%
111	CHARGE Syndrome	11.6%
112	Ischemic contracture	11.5%
113	Bone Diseases	11.3%
114	Rheumatic Fever	11.1%
115	Dural Arteriovenous Fistula	11%
116	Dextrocardia	10.9%
117	Osteogenesis Imperfecta	10.9%
118	Xeroderma	10.3%
119	Mobius Syndrome	10.3%
120	Temporomandibular Joint Dysfunction Syndrome	10.3%
121	Genetic Diseases, Inborn	10.1%
122	Rheumatoid Arthritis	10%
123	Juvenile arthritis	10%
124	Abnormalities, Radiation-Induced	9.9%
125	Hip Contracture	9.8%
126	Periarthritis	9.8%
127	Prune Belly Syndrome	9.8%
128	Twins, Conjoined	9.8%
129	Waardenburg Syndrome	9.8%
130	Ankylosing spondylitis	9.4%
131	Arthritis, Gouty	9.2%
132	Scimitar Syndrome	9.1%
133	Arthritis	9.1%
134	Bursitis	9.1%
135	Joint Instability	9.1%
136	Myofascial Pain Syndromes	9.1%
137	Rhabdomyolysis	9.1%
138	Synovitis	9.1%
139	Joint laxity	9.1%
140	Polyarthritis	9.1%
141	Frozen shoulder	9.1%
142	Patellofemoral Pain Syndrome	9.1%
143	Chondrodysplasia Punctata	8.9%
144	Enchondromatosis	8.9%
145	Osteosclerosis	8.9%
146	Kashin-Beck Disease	8.9%
147	Alstrom Syndrome	8.8%
148	Fetal Diseases	8.8%
149	Polycystic Kidney Diseases	8.7%
150	Williams Syndrome	8.7%
151	Discitis	8.5%
152	Anophthalmos	8.5%
153	Anus, Imperforate	8.5%
154	Hydranencephaly	8.5%
155	Microphthalmos	8.5%
156	Neural Tube Defects	8.5%
157	Tethered Cord Syndrome	8.5%
158	Iniencephaly	8.5%
159	Craniorachischisis	8.5%
160	Exencephaly	8.5%
161	Septo-Optic Dysplasia	8.5%
162	Cortical Dysplasia	8.5%
163	Malformations of Cortical Development	8.5%
164	Anorectal Malformations	8.5%
165	Muscular Dystrophy	8.5%
166	Ainhum	8.4%
167	Spinal Stenosis	8.4%
168	Spondylosis	8.4%
169	Intervertebral Disc Degeneration	8.4%
170	Bloom Syndrome	8.4%
171	Osteoarthritis, Knee	8.4%
172	Eosinophilic Granuloma	8.4%
173	Arthritis, Psoriatic	8.4%
174	Myotonic Dystrophy	8.2%
175	Retinal Dysplasia	8.1%
176	Aniridia	8%
177	Ichthyosis, X-Linked	7.9%
178	Epidermolysis Bullosa	7.9%
179	Compartment syndromes	7.9%
180	Maxillary Diseases	7.9%
181	Tendinitis	7.9%
182	Tendinopathy	7.9%
183	Hemarthrosis	7.8%
184	Myositis	7.8%
185	Tietze's Syndrome	7.8%
186	Isaacs syndrome	7.8%
187	Myotonic Disorders	7.8%
188	Fragile X Syndrome	7.8%
189	Smith-Lemli-Opitz Syndrome	7.7%
190	Tuberculosis, Spinal	7.5%
191	Turner Syndrome	7.5%
192	Cystic Fibrosis	7.5%
193	Blepharophimosis	7.5%
194	Laryngostenosis	7.5%
195	Mouth Abnormalities	7.5%
196	Familial Periodic Paralysis	7.5%
197	Esophageal Atresia	7.5%
198	Intestinal Atresia	7.5%
199	Horseshoe Kidney	7.5%
200	Acrodermatitis	7.4%
201	Lymphangiectasis, Intestinal	7.4%
202	Gianotti-Crosti Syndrome	7.4%
203	Rheumatoid Nodule	7.3%
204	Arthritis, Reactive	7.3%
205	Osteomyelitis	7.3%
206	Osteoporosis	7.3%
207	Periostitis	7.3%
208	Bone Demineralization, Pathologic	7.3%
209	Post-Traumatic Osteoporosis	7.3%
210	Alveolar Bone Loss	7.2%
211	Femur Head Necrosis	7.2%
212	Osteolysis	7.2%
213	Spondylarthropathies	7.2%
214	Muscular Dystrophy, Duchenne	7.1%
215	Medial Tibial Stress Syndrome	6.9%
216	Primary Ciliary Dyskinesia	6.9%
217	Mitochondrial Myopathies	6.8%
218	Muscle Cramp	6.8%
219	Eosinophilia-Myalgia Syndrome	6.8%
220	Muscle Rigidity	6.8%
221	Muscle Spasticity	6.8%
222	Cogwheel Rigidity	6.8%
223	Nuchal Rigidity	6.8%
224	Choanal Atresia	6.7%
225	Tracheobronchomegaly	6.7%
226	Laryngocele	6.7%
227	Meconium Aspiration Syndrome	6.7%
228	Choledochal Cyst	6.7%
229	Hermaphroditism	6.7%
230	Disorders of Sex Development	6.7%
231	Cryptorchidism	6.6%
232	Hypospadias	6.6%
233	Pseudoxanthoma Elasticum	6.6%
234	Bone Diseases, Developmental	6.6%
235	Classical Lissencephalies and Subcortical Band Heterotopias	6.6%
236	Central Nervous System Cysts	6.6%
237	Dandy-Walker Syndrome	6.6%
238	Felty Syndrome	6.5%
239	POEMS Syndrome	6.5%
240	Melorheostosis	6.5%
241	Osteopetrosis	6.5%
242	Pseudohypoparathyroidism	6.4%
243	Acromegaly	6.3%
244	Joint Tuberculosis	6.3%
245	Tuberculosis, Osteoarticular	6.3%
246	Bone Tuberculosis	6.3%
247	Sjogren-Larsson Syndrome	6.3%
248	Chronic Fatigue Syndrome	6.3%
249	Xeroderma Pigmentosum	6.1%
250	Giant Cell Epulis	6.1%
251	Muscle Weakness	6.1%
252	Musculoskeletal Pain	6.1%
253	Arthralgia	6%
254	Myotonia Congenita	6%
255	Polyarthralgia	6%
256	Bladder Exstrophy	6%
257	Epispadias	6%
258	Multicystic Dysplastic Kidney	5.9%
259	Rheumatoid Vasculitis	5.9%
260	Polycystic Kidney, Autosomal Dominant	5.7%
261	Bunion	5.7%
262	Fibrodysplasia Ossificans Progressiva	5.7%
263	Myoglobinuria	5.7%
264	Myositis Ossificans	5.7%
265	Tenosynovitis	5.7%
266	Sacroiliitis	5.7%
267	Lordosis	5.7%
268	Spondylolysis	5.7%
269	kyphosis	5.7%
270	Zellweger Syndrome	5.7%
271	Klinefelter Syndrome	5.7%
272	Kallmann Syndrome	5.6%
273	Rickets	5.6%
274	Ectopia Cordis	5.6%
275	Meningomyelocele	5.6%
276	Spina Bifida	5.6%
277	Single umbilical artery	5.6%
278	Abdominal Cramps	5.5%
279	Amniotic Band Syndrome	5.5%
280	Asphyxia Neonatorum	5.5%
281	Infant, Premature, Diseases	5.5%
282	Infantile Colic	5.5%
283	Welander Distal Myopathy	5.5%
284	Palatal Neoplasms	5.5%
285	Myalgia	5.4%
286	Sicca Syndrome	5.3%
287	Sjogren's Syndrome	5.3%
288	Charcot-Marie-Tooth Disease	5.2%
289	Tuberous Sclerosis	5%
290	Hyperkeratosis, Epidermolytic	5%
291	Arthritis, Infectious	5%
292	Anterior Compartment Syndrome	4.9%
293	Enthesopathy	4.9%
294	Arthritis, Experimental	4.9%
295	Abdominal Compartment Syndrome	4.9%
296	Aortic coarctation	4.9%
297	Cor Triatriatum	4.9%
298	Coronary Vessel Anomalies	4.9%
299	Dental Enamel Hypoplasia	4.9%
300	Patent ductus arteriosus	4.9%
301	Ebstein Anomaly	4.9%
302	Heart Septal Defects	4.9%
303	Hypodontia	4.9%
304	Macrostomia	4.9%
305	Meningocele	4.9%
306	Microstomia	4.9%
307	Tetralogy of Fallot	4.9%
308	Transposition of Great Vessels	4.9%
309	Hypoplastic Left Heart Syndrome	4.9%
310	May-Thurner Syndrome	4.9%
311	Encephalocele	4.9%
312	Polymyositis	4.9%
313	Osteoporosis, Postmenopausal	4.9%
314	Wolff-Parkinson-White Syndrome	4.9%
315	Neoplastic Syndromes, Hereditary	4.9%
316	Hypokalemic periodic paralysis	4.9%
317	Refsum Disease	4.9%
318	Anemia, Neonatal	4.7%
319	Pelger-Huet Anomaly	4.7%
320	Persistent Fetal Circulation Syndrome	4.7%
321	Werner Syndrome	4.7%
322	Myasthenic Syndromes, Congenital	4.7%
323	Umbilical hernia	4.7%
324	Hyperandrogenism	4.5%
325	Albinism	4.4%
326	Hip Dislocation	4.4%
327	Shoulder Dislocation	4.4%
328	Hip Dysplasia	4.4%
329	Long QT Syndrome	4.4%
330	Tricuspid Atresia	4.4%
331	Arrhythmogenic Right Ventricular Dysplasia	4.4%
332	Anemia, Sickle Cell	4.4%
333	Thalassemia	4.4%
334	Dysostoses	4.4%
335	Gonadal Dysgenesis	4.4%
336	Adrenogenital Syndrome	4.4%
337	Ovotesticular Disorders of Sex Development	4.4%
338	Orbital Myositis	4.3%
339	Spondylolisthesis	4.3%
340	Dupuytren Contracture	4.3%
341	Pyomyositis	4.3%
342	Mastoiditis	4.3%
343	Petrositis	4.3%
344	Neonatal Abstinence Syndrome	4.2%
345	Dermal Sinus	4.2%
346	Spina Bifida Cystica	4.2%
347	Spina Bifida Occulta	4.2%
348	Lissencephaly	4.2%
349	Polymicrogyria	4.2%
350	Pachygyria	4.2%
351	Schizencephaly	4.2%
352	Periventricular Nodular Heterotopia	4.2%
353	Fetal Growth Retardation	4.1%
354	Fetal Hypoxia	4.1%
355	Congenital nystagmus	4.1%
356	Fetal Alcohol Spectrum Disorders	4.1%
357	Toxoplasmosis, Congenital	4.1%
358	Syphilis, Congenital	4.1%
359	Shoulder Pain	3.8%
360	Osteomalacia	3.8%
361	Autoimmune Lymphoproliferative Syndrome	3.7%
362	Congenital Hyperinsulinism	3.7%
363	Chorioamnionitis	3.7%
364	Aortopulmonary Septal Defect	3.6%
365	Double Outlet Right Ventricle	3.6%
366	Endocardial Cushion Defects	3.6%
367	Myocardial bridging	3.6%
368	Aorticopulmonary Septal Defect	3.6%
369	Angioedemas, Hereditary	3.6%
370	Wiskott-Aldrich Syndrome	3.6%
371	Mucopolysaccharidosis II	3.5%
372	Menkes Kinky Hair Syndrome	3.5%
373	Mitochondrial Encephalomyopathies	3.4%
374	Familial Mediterranean Fever	3.3%
375	Rett Syndrome	3.2%
376	Romano-Ward Syndrome	3.2%
377	Truncus Arteriosus, Persistent	3%
378	Ophthalmia Neonatorum	3%
379	Nose Neoplasms	2.9%
380	Neuronal Ceroid-Lipofuscinoses	2.9%
381	Adrenoleukodystrophy	2.9%
382	Sickle Cell Trait	2.9%
383	Hepatolenticular Degeneration	2.9%
384	Paralysis, Obstetric	2.8%
385	Retinopathy of Prematurity	2.8%
386	Renal Osteodystrophy	2.8%
387	Renal rickets	2.8%
388	Amino Acid Metabolism, Inborn Errors	2.8%
389	Carbohydrate Metabolism, Inborn Errors	2.8%
390	Metal Metabolism, Inborn Errors	2.8%
391	Progeria	2.8%
392	Lysosomal Storage Diseases	2.8%
393	Cytochrome-c Oxidase Deficiency	2.8%
394	Peroxisomal Disorders	2.8%
395	Bronchopulmonary Dysplasia	2.8%
396	Ataxia Telangiectasia	2.8%
397	Dermatomyositis	2.8%
398	Amyloid Neuropathies, Familial	2.7%
399	Arteriovenous fistula	2.7%
400	MELAS Syndrome	2.6%
401	Familial Hypophosphatemic Rickets	2.6%
402	Fabry Disease	2.5%
403	Respiratory Distress Syndrome, Newborn	2.5%
404	Cutis Laxa	2.5%
405	Retinitis Pigmentosa	2.5%
406	Pigmentary retinopathy	2.5%
407	Porokeratosis	2.5%
408	Keratoderma, Palmoplantar	2.5%
409	Hydrops Fetalis	2.5%
410	Denys-Drash Syndrome	2.5%
411	Chronic granulomatous disease	2.5%
412	Acute Chest Syndrome	2.4%
413	Galactosemias	2.4%
414	Urea Cycle Disorders, Inborn	2.4%
415	Tyrosinemias	2.4%
416	Canavan Disease	2.2%
417	Alexander Disease	2.2%
418	Duane Retraction Syndrome	2.2%
419	Glycogen storage disease type II	2.2%
420	Porphyrias, Hepatic	2.2%
421	Peutz-Jeghers Syndrome	2.2%
422	Thrombasthenia	2.2%
423	Antithrombin III Deficiency	2.2%
424	Protein C Deficiency	2.2%
425	Brain Diseases, Metabolic, Inborn	2.2%
426	Afibrinogenemia	2.2%
427	Dystonia Musculorum Deformans	2.2%
428	Factor VII Deficiency	2.2%
429	Factor X Deficiency	2.2%
430	Factor XII Deficiency	2.2%
431	Hemophilia A	2.2%
432	Leukomalacia, Periventricular	2.2%
433	Activated Protein C Resistance	2.2%
434	Factor II deficiency	2.2%
435	Factor VIII Deficiency	2.2%
436	Factor V deficiency	2.2%
437	Factor XI Deficiency	2.2%
438	Hypoprothrombinemias	2.2%
439	Fanconi Anemia	2.2%
440	Nesidioblastosis	2.2%
441	Optic Atrophy, Hereditary, Leber	2.2%
442	Lafora Disease	2.2%
443	Unverricht-Lundborg Syndrome	2.2%
444	Anemia, Diamond-Blackfan	2.2%
445	Hyperphosphaturia	2.2%
446	Multiple Endocrine Neoplasia	2%
447	Dermatitis, Atopic	2%
448	Radicular Cyst	1.9%
449	Mucopolysaccharidosis III	1.9%
450	Homocystinuria	1.9%
451	Leigh Disease	1.9%
452	Alkaptonuria	1.9%
453	Glycogen Storage Disease	1.9%
454	Hypophosphatasia	1.9%
455	Propionic acidemia	1.9%
456	Dihydropyrimidine Dehydrogenase Deficiency	1.9%
457	Cystinosis	1.9%
458	Kernicterus	1.8%
459	Behcet Syndrome	1.8%
460	Gaucher Disease	1.7%
461	Hyaline Membrane Disease	1.6%
462	Huntington Disease	1.6%
463	Hypolipoproteinemias	1.6%
464	Papillon-Lefevre Disease	1.6%
465	Hyperlipidemia, Familial Combined	1.6%
466	Hyperlipoproteinemia Type III	1.6%
467	Kearns-Sayre syndrome	1.6%
468	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.6%
469	Nephroblastoma	1.5%
470	Lactose Intolerance	1.4%
471	Variegate Porphyria	1.4%
472	Acute intermittent porphyria	1.4%
473	Porphyria Cutanea Tarda	1.4%
474	Tay-Sachs Disease	1.4%
475	Hyperhomocysteinemia	1.4%
476	Renal Aminoacidurias	1.4%
477	Fanconi Syndrome	1.4%
478	Pseudohypoaldosteronism	1.4%
479	Liddle Syndrome	1.4%
480	Hyperlipoproteinemia Type IV	1.4%
481	Hyperlipoproteinemia Type V	1.4%
482	Niemann-Pick Disease, Type C	1.4%
483	Adenomatous Polyposis Coli	1.4%
484	Glycogen Storage Disease Type I	1.4%
485	Glycogen Storage Disease Type V	1.4%
486	Multiple Endocrine Neoplasia Type 1	1.3%
487	Friedreich Ataxia	1.3%
488	Renal tubular acidosis	1.3%
489	Hypoalphalipoproteinemias	1.2%
490	Glycosuria, Renal	1.1%
491	Cystinuria	1.1%

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