MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Vitamin K Deficiency

(UMLS:C0042880)

Definition:: A nutritional condition produced by a deficiency of VITAMIN K in the diet, characterized by an increased tendency to hemorrhage (HEMORRHAGIC DISORDERS). Such bleeding episodes may be particularly severe in newborn infants. (From Cecil Textbook of Medicine, 19th ed, p1182)
UMLS ID:: C0042880
MeSH ID:: D014813

Classification 1:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.100.920|C15.378.463.841

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.654.521.500.133.912

Synonym(s)

Vitamin K Deficiency

Deficiency of vitamin K

Hypovitaminosis K

VITAMIN K DEFICIENCY

Vitamin K Deficiency Coagulation Disorder

Vitamin K deficiency

Vitamin K deficiency disease

deficiencies k vitamin

deficiency k vitamin

10.

deficiency of vitamin k

11.

deficiency vitamin k

12.

deficiency; vitamin K

13.

disease vitamin k deficiency

14.

k vitamin deficiency

15.

of vitamin k deficiency

16.

vitamin K deficiency

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Ibuprofen	FAERS: 7		US FAERS
2	Warfarin	FAERS: 5		US FAERS
3	Doxycycline	FAERS: 4		US FAERS
4	Warfarin	FAERS: 4		US FAERS
5	Trimethoprim, Sulfamethoxazole Drug Combination	FAERS: 3		US FAERS
6	Valproic Acid	FAERS: 3		US FAERS
7	Ciprofloxacin	FAERS: 2		US FAERS
8	Meropenem	FAERS: 2		US FAERS
9	Orlistat	FAERS: 2		OFFSIDES US FAERS
10	Carbamazepine	FAERS: 1		US FAERS
11	Cefazolin	FAERS: 1		US FAERS
12	Cefoperazone	FAERS: 1		US FAERS
13	Ceftriaxone	FAERS: 1		US FAERS
14	Cetirizine	FAERS: 1		US FAERS
15	Dabigatran	FAERS: 1		US FAERS
16	Dabigatran	FAERS: 1		US FAERS
17	Ezetimibe	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
18	Furosemide	FAERS: 1		US FAERS
19	Sorafenib	FAERS: 1		US FAERS
20	Sulfamethoxazole	FAERS: 1		US FAERS
21	Tazobactam	FAERS: 1		US FAERS
22	lanreotide	FAERS: 1		US FAERS
23	Albuterol			OFFSIDES
24	Ambroxol			OFFSIDES
25	Ampicillin			OFFSIDES
26	Bimatoprost			OFFSIDES
27	Bortezomib			OFFSIDES
28	Caffeine mixture with phenobarbital			OFFSIDES
29	Cefepime			OFFSIDES
30	Cefuroxime			OFFSIDES
31	Cetirizine			OFFSIDES
32	Cholestyramine Resin			SIDER
33	Citalopram			OFFSIDES
34	Clobazam			OFFSIDES
35	Clomipramine			OFFSIDES
36	Cloxacillin			OFFSIDES
37	Cyclopentolate			OFFSIDES
38	Diazepam			OFFSIDES
39	Dicloxacillin			OFFSIDES
40	Diphenoxylate			OFFSIDES
41	Flurbiprofen			OFFSIDES
42	Granisetron			OFFSIDES
43	Itraconazole			OFFSIDES
44	Leflunomide			OFFSIDES
45	Medroxyprogesterone			OFFSIDES
46	Meperidine			OFFSIDES
47	Micafungin			OFFSIDES
48	Miconazole			OFFSIDES
49	Moxalactam		1561959	CTD
50	Neominophagen C			OFFSIDES
51	Nicardipine			OFFSIDES
52	Pamidronate			OFFSIDES
53	Phenobarbital			SIDER
54	Phenprocoumon			OFFSIDES
55	Phosphates			OFFSIDES
56	Quinidine			OFFSIDES
57	S 1108			OFFSIDES
58	Salmeterol Xinafoate			OFFSIDES
59	Sodium Bicarbonate			OFFSIDES
60	Vitamin K 1			OFFSIDES
61	argatroban			OFFSIDES
62	chlorhexidine gluconate			OFFSIDES
63	colestimide			SIDER
64	flomoxef			OFFSIDES
65	posaconazole			SIDER
66	pranlukast			OFFSIDES
67	sivelestat			OFFSIDES
68	temocapril hydrochloride			OFFSIDES
69	urinastatin			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Disseminated Intravascular Coagulation	57.3%
2	Thrombocythemia, Essential	52.8%
3	Protein S Deficiency	48.5%
4	Afibrinogenemia	46.8%
5	Factor VII Deficiency	46.8%
6	Factor X Deficiency	46.8%
7	Factor XII Deficiency	46.8%
8	Hemophilia A	46.8%
9	Factor II deficiency	46.8%
10	Factor VIII Deficiency	46.8%
11	Factor V deficiency	46.8%
12	Factor XI Deficiency	46.8%
13	Hypoprothrombinemias	46.8%
14	Thrombasthenia	44.2%
15	Activated Protein C Resistance	39.3%
16	Antithrombin III Deficiency	36.7%
17	Protein C Deficiency	36.7%
18	Wiskott-Aldrich Syndrome	31%
19	Anemia	30.1%
20	Blood Platelet Disorders	30.1%
21	Bone Marrow Diseases	30.1%
22	Leukocyte Disorders	30.1%
23	Methemoglobinemia	30.1%
24	Pancytopenia	30.1%
25	Polycythemia	30.1%
26	Sulfhemoglobinemia	30.1%
27	Thrombophilia	30.1%
28	Erythrocytosis	30.1%
29	Scurvy	28.9%
30	Thrombocytosis	27.5%
31	Bone Marrow Neoplasms	26.4%
32	Autoimmune thrombocytopenia	25.8%
33	Immune thrombocytopenic purpura	25.8%
34	Purpura, Thrombotic Thrombocytopenic	25.2%
35	Ascorbic Acid Deficiency	25.2%
36	Vitamin A Deficiency	25.2%
37	Vitamin D Deficiency	25.2%
38	Vitamin E Deficiency	25.2%
39	Transfusion Reaction	25.1%
40	Hypotensive Transfusion Reaction	25.1%
41	Polycythemia Vera	25.1%
42	Purpura, Hyperglobulinemic	24.4%
43	Pregnancy Complications, Hematologic	24.4%
44	Hematologic Neoplasms	24.4%
45	Hemoglobinuria, Paroxysmal	23.5%
46	Leukemoid Reaction	23.5%
47	Cryoglobulinemia	22.5%
48	Anemia, Diamond-Blackfan	22.3%
49	Anemia, Pernicious	22.2%
50	Ecchymosis	22%
51	Petechiae	22%
52	Purpura	22%
53	Waldenstrom Macroglobulinemia	20.5%
54	Anemia, Hemolytic	19.8%
55	Anemia, Macrocytic	19.8%
56	Eosinophilia	19.8%
57	Hypoproteinemia	19.8%
58	Leukopenia	19.8%
59	Thrombocytopenia	19.8%
60	Leukostasis	19.8%
61	MYELODYSPLASTIC SYNDROME	19.8%
62	Waterhouse-Friderichsen Syndrome	18.9%
63	Folic Acid Deficiency	18.9%
64	Pellagra	18.9%
65	Thiamine Deficiency	18.9%
66	Vitamin B 12 Deficiency	18.9%
67	Vitamin B 6 Deficiency	18.9%
68	Pyridoxine Deficiency	18.9%
69	Thrombocytopenic purpura	18.8%
70	Magnesium Deficiency	18.4%
71	Potassium Deficiency	18.4%
72	Protein Deficiency	18.4%
73	Anemia, Sickle Cell	18.3%
74	Thalassemia	18.3%
75	Agammaglobulinemia	17.8%
76	Multiple Myeloma	17.6%
77	Lymphatic Diseases	17.3%
78	Monoclonal Gammopathy of Undetermined Significance	16.9%
79	Shwartzman Phenomenon	16.4%
80	Hemangioma, Cavernous	16.3%
81	Purpura Fulminans	16.3%
82	Anemia, Neonatal	16.1%
83	Leukocytosis	16.1%
84	Paraproteinemias	16.1%
85	Pelger-Huet Anomaly	16.1%
86	Pleocytosis	16.1%
87	Beriberi	15.7%
88	Hemolytic-Uremic Syndrome	15.2%
89	Fanconi Anemia	15.2%
90	Blood Coagulation Disorders	15.1%
91	Hemorrhagic Disorders	15.1%
92	Infectious Mononucleosis	15.1%
93	Primary Myelofibrosis	14.7%
94	Agranulocytosis	14.7%
95	Anemia, Megaloblastic	14.7%
96	Lymphocytosis	14.7%
97	Myelofibrosis	14.7%
98	Myeloid Metaplasia	14.7%
99	Hypoalbuminemia	14.7%
100	Hypereosinophilic syndrome	14.7%
101	bone marrow fibrosis	14.7%
102	Thrombotic Microangiopathies	14.7%
103	Sickle Cell Trait	14.6%
104	Starvation	14.4%
105	Refeeding Syndrome	14.4%
106	Heavy Chain Disease	14.2%
107	Hypergammaglobulinemia	13.5%
108	Transfusion-Related Acute Lung Injury	13.3%
109	Rickets	13.2%
110	Vitamin K Deficiency	13.1%
111	Atypical Hemolytic Uremic Syndrome	13.1%
112	Hydrops Fetalis	12.9%
113	Hyperhomocysteinemia	12.7%
114	Wasting Syndrome	12.2%
115	Neutropenia	12.2%
116	Marasmus	12.2%
117	Lymphopenia	12%
118	Job Syndrome	11.8%
119	Leukemia, Myelomonocytic, Chronic	11.7%
120	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	11.7%
121	Acute Chest Syndrome	11.6%
122	Child Nutrition Disorders	11.3%
123	Hypervitaminosis A	11.3%
124	Infant Nutrition Disorders	11.3%
125	Febrile Neutropenia	11%
126	Osteomalacia	10.3%
127	Adenitis	10%
128	Histiocytosis	10%
129	Lymphadenitis	10%
130	Lymphangitis	10%
131	Lymphedema	10%
132	Splenic Diseases	10%
133	Thymus Hyperplasia	10%
134	Pseudolymphoma	10%
135	Lymphadenopathy	10%
136	Pseudoxanthoma Elasticum	10%
137	Eosinophilia-Myalgia Syndrome	10%
138	Pulmonary Eosinophilia	9.9%
139	Eosinophilic Pneumonia	9.9%
140	Eosinophilic Granuloma	9.9%
141	Chronic granulomatous disease	9.9%
142	Kernicterus	9.8%
143	Leukemia, Myeloid, Chronic-Phase	9.7%
144	Wernicke Encephalopathy	9%
145	Lymphangiectasis, Intestinal	8.8%
146	Kwashiorkor	8.6%
147	POEMS Syndrome	8.4%
148	Lymphocele	8.1%
149	Lymphoproliferative Disorders	8.1%
150	Lymphatic Abnormalities	8.1%
151	Subacute Combined Degeneration	8.1%
152	Thymus Neoplasms	8%
153	Metabolic Diseases	7.4%
154	Renal Osteodystrophy	7.3%
155	Renal rickets	7.3%
156	Mucocutaneous Lymph Node Syndrome	6.7%
157	Elephantiasis	6.6%
158	Hypersplenism	6.6%
159	Sarcoidosis	6.6%
160	Elephantiasis Nostras Verrucosa	6.6%
161	Granuloma	5.4%
162	Histiocytic Disorders, Malignant	5.4%
163	Splenic Infarction	5.4%
164	Splenic Neoplasms	5.4%
165	Histiocytosis, Langerhans-Cell	5.3%
166	Tumor Lysis Syndrome	5.3%
167	Familial Hypophosphatemic Rickets	5%
168	Sezary Syndrome	5%
169	Lymphohistiocytosis, Hemophagocytic	4.9%
170	Erdheim-Chester Disease	4.9%
171	Splenic Rupture	4.5%
172	Lymphoma	4.5%
173	Thymoma	4.4%
174	HIV Wasting Syndrome	4.1%
175	Malignant histiocytosis	3.9%
176	Sarcoidosis, Pulmonary	3.9%
177	Histiocytic sarcoma	3.9%
178	Autoimmune Lymphoproliferative Syndrome	3.9%
179	Acid-Base Imbalance	3.8%
180	Calcium Metabolism Disorders	3.8%
181	Iron Metabolism Disorders	3.8%
182	Phosphorus Metabolism Disorders	3.8%
183	Water-Electrolyte Imbalance	3.8%
184	Lipid Metabolism Disorders	3.8%
185	Mitochondrial Diseases	3.8%
186	Glucose Metabolism Disorders	3.8%
187	Obesity	3.5%
188	Hypercalcemia	3.3%
189	Hypocalcemia	3.3%
190	Milk-Alkali Syndrome	3.3%
191	Splenosis	3.3%
192	Hodgkin Disease	3.3%
193	Lymphoma, Non-Hodgkin	3.3%
194	Leukemia, T-Cell	3.3%
195	Leukemia, B-Cell	3.3%
196	Osteopenia	3.1%
197	Brain Diseases, Metabolic	3%
198	Composite Lymphoma	2.8%
199	Lymphangioleiomyomatosis	2.8%
200	Lipodystrophy	2.8%
201	Lymphoma, Follicular	2.7%
202	T-Cell Lymphoma	2.7%
203	Mantle cell lymphoma	2.7%
204	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2.7%
205	Leukemia, Large Granular Lymphocytic	2.7%
206	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2.7%
207	Pseudohypoparathyroidism	2.7%
208	Obesity, Abdominal	2.4%
209	Lymphoma, T-Cell, Cutaneous	2.4%
210	Lymphoma, AIDS-Related	2.4%
211	Enteropathy-Associated T-Cell Lymphoma	2.4%
212	Primary Effusion Lymphoma	2.4%
213	Brain Diseases, Metabolic, Inborn	2.4%
214	Mycosis Fungoides	2.3%
215	Lymphomatoid Papulosis	2.3%
216	Plasmablastic lymphoma	2.3%
217	Leigh Disease	2.1%
218	Lymphomatoid Granulomatosis	2.1%
219	Pediatric Obesity	2.1%
220	Acidosis	2.1%
221	Alkalosis	2.1%
222	Amyloidosis	2.1%
223	Calcinosis	2.1%
224	Hyperglycemia	2.1%
225	Hyperinsulinism	2.1%
226	Hyperkalemia	2.1%
227	Hypernatremia	2.1%
228	Hypoglycemia	2.1%
229	Hypokalemia	2.1%
230	Hyponatremia	2.1%
231	Xanthomatosis	2.1%
232	Hypophosphatemia	2.1%
233	Metabolic acidosis	2.1%
234	Dyslipidemias	2.1%
235	Iron Overload	2.1%
236	Xanthoma	2.1%
237	Niemann-Pick Disease, Type C	2%
238	Lactose Intolerance	1.9%
239	Prader-Willi Syndrome	1.8%
240	Burkitt Lymphoma	1.8%
241	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.8%
242	Diabetes Mellitus	1.7%
243	Dehydration	1.7%
244	Lipomatosis	1.7%
245	Water Intoxication	1.7%
246	Werner Syndrome	1.7%
247	Achlorhydria	1.7%
248	Amino Acid Metabolism, Inborn Errors	1.7%
249	Bloom Syndrome	1.7%
250	Carbohydrate Metabolism, Inborn Errors	1.7%
251	Metal Metabolism, Inborn Errors	1.7%
252	Osteoporosis	1.7%
253	Progeria	1.7%
254	Lysosomal Storage Diseases	1.7%
255	Bone Demineralization, Pathologic	1.7%
256	Cytochrome-c Oxidase Deficiency	1.7%
257	Peroxisomal Disorders	1.7%
258	Post-Traumatic Osteoporosis	1.7%
259	Celiac Disease	1.6%
260	Sprue, Tropical	1.6%
261	Steatorrhea	1.6%
262	Sprue	1.6%
263	Mitochondrial Encephalomyopathies	1.6%
264	Smith-Lemli-Opitz Syndrome	1.6%
265	Hypolipoproteinemias	1.6%
266	Galactosemias	1.6%
267	Urea Cycle Disorders, Inborn	1.6%
268	Tyrosinemias	1.6%
269	Hyperphosphaturia	1.5%
270	Congenital Hyperinsulinism	1.4%
271	Mitochondrial Myopathies	1.4%
272	Myelinolysis, Central Pontine	1.4%
273	Hyperlipoproteinemia Type IV	1.4%
274	Hyperlipoproteinemia Type V	1.4%
275	Glycosuria	1.4%
276	Reye Syndrome	1.4%
277	Hepatic Encephalopathy	1.4%
278	Diabetic Ketoacidosis	1.4%
279	Hyperlipidemia, Familial Combined	1.4%
280	Homocystinuria	1.3%
281	Acidosis, Lactic	1.2%
282	Calciphylaxis	1.2%
283	Hemosiderosis	1.2%
284	Ketosis	1.2%
285	Ketonuria	1.2%
286	Ketoacidosis	1.2%
287	Ketonemia	1.2%
288	Vascular calcification	1.2%
289	Renal tubular acidosis	1.2%
290	Hyperlipoproteinemia Type III	1.2%
291	Porphyrias, Hepatic	1.2%
292	Necrobiosis Lipoidica Diabeticorum	1.2%
293	Glycogen storage disease type II	1.2%
294	Amyloid Neuropathies, Familial	1.1%
295	Zellweger Syndrome	1.1%
296	Menkes Kinky Hair Syndrome	1.1%
297	Adrenoleukodystrophy	1.1%
298	HIV-Associated Lipodystrophy Syndrome	1.1%
299	Hypoalphalipoproteinemias	1.1%
300	MELAS Syndrome	1.1%
301	Gaucher Disease	1.1%
302	Hepatolenticular Degeneration	1.1%
303	Refsum Disease	1%
304	Neuronal Ceroid-Lipofuscinoses	1%
305	Friedreich Ataxia	1%
306	Acidosis, Respiratory	1%
307	Adiposis Dolorosa	1%
308	Alkalosis, Respiratory	1%
309	Alkaptonuria	1%
310	Glycogen Storage Disease	1%
311	Hypophosphatasia	1%
312	Insulin Resistance	1%
313	Osteoporosis, Postmenopausal	1%
314	Propionic acidemia	1%
315	Dihydropyrimidine Dehydrogenase Deficiency	1%
316	Cystinosis	1%
317	Glycosuria, Renal	1%
318	Nesidioblastosis	0.9%
319	Cockayne Syndrome	0.9%
320	Kearns-Sayre syndrome	0.9%
321	Fabry Disease	0.9%
322	Gestational Diabetes	0.8%
323	Latent Autoimmune Diabetes in Adults	0.8%
324	Ataxia Telangiectasia	0.8%
325	Diabetes Mellitus, Experimental	0.8%
326	Nephrocalcinosis	0.8%
327	Tetany	0.8%
328	Optic Atrophy, Hereditary, Leber	0.8%
329	Hypercholesterolemia	0.8%
330	Hyperlipoproteinemias	0.8%
331	Hypertriglyceridemia	0.8%
332	Cerebral Amyloid Angiopathy	0.8%
333	Mucopolysaccharidosis III	0.8%
334	Tay-Sachs Disease	0.8%
335	Xeroderma Pigmentosum	0.8%
336	Familial Periodic Paralysis	0.7%
337	Primary amyloidosis	0.7%
338	Variegate Porphyria	0.7%
339	Acute intermittent porphyria	0.7%
340	Porphyria Cutanea Tarda	0.7%
341	Renal Aminoacidurias	0.7%
342	Fanconi Syndrome	0.7%
343	Pseudohypoaldosteronism	0.7%
344	Liddle Syndrome	0.7%
345	Sjogren-Larsson Syndrome	0.7%
346	Glycogen Storage Disease Type I	0.6%
347	Glycogen Storage Disease Type V	0.6%
348	Gout	0.6%
349	Amyotrophic Lateral Sclerosis	0.6%
350	Antley-Bixler Syndrome Phenotype	0.6%
351	Canavan Disease	0.6%
352	Alexander Disease	0.6%
353	Mucopolysaccharidosis II	0.6%
354	CREST Syndrome	0.5%
355	Albinism	0.5%
356	Hypokalemic periodic paralysis	0.5%
357	Frontotemporal dementia	0.5%
358	Cystinuria	0.5%
359	Ichthyosis, X-Linked	0.4%
360	Arthritis, Gouty	0.4%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234