MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Arthrogryposis

(UMLS:C0003886)

Definition:: Persistent flexure or contracture of a joint.
UMLS ID:: C0003886
MeSH ID:: D001176

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.550.150|C05.651.102|C05.660.077

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.621.077

Synonym(s)

Arthrogryposis

AMC - Arthrogryposis multiplex congenita

AMC-Arthrogryposis multiplex congenita

ARTHROGRYPOSIS

Amyoplasia congenita

Arthrogryposis multiplex

Arthrogryposis multiplex congenita

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Nicotine		8073369	CTD
2	coniine		8073369	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Contracture	47.1%
2	Acrocephalosyndactylia	45.7%
3	Craniosynostosis	43.2%
4	Syndactyly	43.2%
5	Brachycephaly	43.2%
6	Pectus excavatum	42.6%
7	Pectus carinatum	42.3%
8	Klippel-Feil Syndrome	40.9%
9	Synostosis	40.9%
10	Limb Deformities, Congenital	39.5%
11	Craniofacial Abnormalities	39.5%
12	Ischemic contracture	38.5%
13	Osteoarthropathy, Secondary Hypertrophic	37.6%
14	Platybasia	37%
15	Poland Syndrome	36.1%
16	Hip Contracture	34.5%
17	Periarthritis	34.5%
18	Osteoarthritis, Spine	34.3%
19	Gastroschisis	33.5%
20	Temporomandibular Joint Dysfunction Syndrome	33.3%
21	Gout	33%
22	Temporomandibular Joint Disorders	32.9%
23	Craniofacial Dysostosis	32%
24	Fibromyalgia	32%
25	Polymyalgia Rheumatica	32%
26	Metatarsalgia	31.8%
27	Ankylosing spondylitis	31.5%
28	Talipes	31.3%
29	Amelia	29.1%
30	Arachnodactyly	29.1%
31	Ectromelia	29.1%
32	Hemimelia	29.1%
33	Phocomelia	29.1%
34	Sirenomelia	29.1%
35	Polydactyly	29.1%
36	Brachydactyly	29.1%
37	Plagiocephaly	29.1%
38	Lower Extremity Deformities, Congenital	29.1%
39	Upper Extremity Deformities, Congenital	29.1%
40	Rubinstein-Taybi Syndrome	28.7%
41	Fasciitis, Plantar	28.2%
42	Arthritis	28.2%
43	Bursitis	28.2%
44	Joint Instability	28.2%
45	Myofascial Pain Syndromes	28.2%
46	Rhabdomyolysis	28.2%
47	Synovitis	28.2%
48	Joint laxity	28.2%
49	Polyarthritis	28.2%
50	Frozen shoulder	28.2%
51	Patellofemoral Pain Syndrome	28.2%
52	Congenital clubfoot	27.6%
53	Vertical Talus	27.6%
54	Arthritis, Psoriatic	27.4%
55	Maxillofacial Abnormalities	27%
56	Holoprosencephaly	27%
57	Rheumatic Fever	26.6%
58	Arthritis, Gouty	26.2%
59	Bone Diseases	26.1%
60	Fasciitis	26.1%
61	Foot Deformities	26.1%
62	Jaw Abnormalities	25.7%
63	Arthritis, Reactive	25.3%
64	Nail-Patella Syndrome	25.2%
65	Antley-Bixler Syndrome Phenotype	25.1%
66	Microcephaly	24.6%
67	Macrocephaly	24.6%
68	Osteoarthritis, Knee	24.6%
69	Goldenhar Syndrome	24.4%
70	Osteochondritis	24%
71	Compartment syndromes	23.5%
72	Tendinitis	23.5%
73	Mandibulofacial Dysostosis	23.5%
74	Tendinopathy	23.5%
75	Rheumatoid Arthritis	23.5%
76	Juvenile arthritis	23.5%
77	Hemarthrosis	23.3%
78	Myositis	23.3%
79	Isaacs syndrome	23.3%
80	Myotonic Disorders	23.3%
81	Prognathism	22.7%
82	Jaw Diseases	22.2%
83	Spondylarthropathies	21.8%
84	Cartilage Diseases	21.7%
85	Foot Diseases	21.7%
86	Rheumatism	21.7%
87	Chondromalacia	21.7%
88	Micrognathism	21.3%
89	Pierre Robin Syndrome	21.3%
90	Arthrogryposis	21.1%
91	Porencephaly	20.9%
92	Rheumatoid Nodule	20.9%
93	Fibrodysplasia Ossificans Progressiva	20.8%
94	Myoglobinuria	20.8%
95	Myositis Ossificans	20.8%
96	Tenosynovitis	20.8%
97	Sacroiliitis	20.8%
98	Noonan Syndrome	20.4%
99	Laryngomalacia	20.2%
100	Medial Tibial Stress Syndrome	20%
101	Mitochondrial Myopathies	19.8%
102	Muscle Cramp	19.7%
103	Eosinophilia-Myalgia Syndrome	19.7%
104	Muscle Rigidity	19.6%
105	Muscle Spasticity	19.6%
106	Cogwheel Rigidity	19.6%
107	Nuchal Rigidity	19.6%
108	Retrognathia	19.3%
109	Myotonic Dystrophy	19.2%
110	Cleft Palate	18.6%
111	Familial Periodic Paralysis	18.4%
112	Felty Syndrome	18.2%
113	Chronic Fatigue Syndrome	17.9%
114	Muscular Dystrophy	17.7%
115	Gigantism	17.6%
116	Spinal Neoplasms	17.6%
117	Spondylitis	17.6%
118	Arthritis, Infectious	17.4%
119	Arthropathy	17.4%
120	Muscle Weakness	17.3%
121	Anterior Compartment Syndrome	17.2%
122	Enthesopathy	17.2%
123	Arthritis, Experimental	17.2%
124	Abdominal Compartment Syndrome	17.2%
125	Musculoskeletal Pain	17.2%
126	Polymyositis	17.1%
127	Arthralgia	17%
128	Polyarthralgia	17%
129	Bone Diseases, Developmental	16.9%
130	Hyperostosis	16.9%
131	Osteitis	16.9%
132	Osteitis Deformans	16.9%
133	Osteochondrosis	16.9%
134	Spinal Diseases	16.9%
135	Bronchomalacia	16.5%
136	Tracheomalacia	16.5%
137	Rheumatoid Vasculitis	16.1%
138	Myalgia	15.1%
139	Hip Dislocation	15%
140	Shoulder Dislocation	15%
141	Hip Dysplasia	15%
142	Orbital Myositis	14.8%
143	Dupuytren Contracture	14.7%
144	Pyomyositis	14.6%
145	Discitis	14.5%
146	Sicca Syndrome	14.5%
147	Sjogren's Syndrome	14.5%
148	Myotonia Congenita	14.5%
149	Bone Diseases, Endocrine	14.5%
150	Myopathy	14.5%
151	Bone Diseases, Infectious	14.1%
152	Bone neoplasms	14.1%
153	Maxillary Diseases	14.1%
154	Osteopenia	14.1%
155	Congenital Hypothyroidism	14.1%
156	Welander Distal Myopathy	14%
157	Marfan Syndrome	14%
158	Bone Resorption	14%
159	Muscular Dystrophy, Duchenne	14%
160	Multiple Epiphyseal Dysplasia	14%
161	Osteochondrodysplasias	14%
162	Tietze's Syndrome	14%
163	Aseptic Necrosis of Bone	14%
164	Beckwith-Wiedemann Syndrome	13.7%
165	Wolf-Hirschhorn Syndrome	13.7%
166	Hypokalemic periodic paralysis	13.7%
167	Abnormalities, Drug-Induced	12.7%
168	Situs Inversus	12.7%
169	Basal Cell Nevus Syndrome	12.6%
170	Shoulder Pain	12.6%
171	Tuberculosis, Spinal	12.6%
172	Ainhum	12.5%
173	Bunion	12.5%
174	Dysostoses	12.5%
175	Spinal Stenosis	12.5%
176	Spondylosis	12.5%
177	Intervertebral Disc Degeneration	12.5%
178	Dwarfism	12.2%
179	Smith-Magenis syndrome	12.1%
180	Aicardi's syndrome	12%
181	Cri-du-Chat Syndrome	11.9%
182	Down Syndrome	11.9%
183	Trisomy 21	11.9%
184	Cockayne Syndrome	11.9%
185	Mitochondrial Encephalomyopathies	11.2%
186	Eye Abnormalities	10.8%
187	Cardiovascular Abnormalities	10.8%
188	Dermatomyositis	10.8%
189	Ectodermal Dysplasia	10.6%
190	Aplasia Cutis Congenita	10.6%
191	Skin Abnormalities	10.6%
192	Lymphatic Abnormalities	10.6%
193	Congenital Microtia	10.6%
194	Palatal Neoplasms	10.6%
195	Prader-Willi Syndrome	10.5%
196	Congenital diaphragmatic hernia	10.4%
197	Giant Cell Epulis	10.4%
198	Chondrodysplasia Punctata	10.3%
199	Enchondromatosis	10.3%
200	Lordosis	10.3%
201	Osteogenesis Imperfecta	10.3%
202	Osteomyelitis	10.3%
203	Osteoporosis	10.3%
204	Osteosclerosis	10.3%
205	Periostitis	10.3%
206	Spondylolysis	10.3%
207	Bone Demineralization, Pathologic	10.3%
208	Post-Traumatic Osteoporosis	10.3%
209	kyphosis	10.3%
210	Kashin-Beck Disease	10.3%
211	Alveolar Bone Loss	10.3%
212	Femur Head Necrosis	10.3%
213	Osteolysis	10.3%
214	Anencephaly	10.2%
215	Kartagener Syndrome	9.5%
216	Melorheostosis	9.3%
217	Osteopetrosis	9.3%
218	Spondylolisthesis	9.3%
219	Urogenital Abnormalities	9.3%
220	Eosinophilic Granuloma	9.1%
221	Dural Arteriovenous Fistula	9%
222	Dextrocardia	8.9%
223	CHARGE Syndrome	8.9%
224	Acromegaly	8.7%
225	Joint Tuberculosis	8.7%
226	Tuberculosis, Osteoarticular	8.7%
227	Bone Tuberculosis	8.7%
228	Osteoporosis, Postmenopausal	8.5%
229	Prune Belly Syndrome	8.3%
230	Twins, Conjoined	8.3%
231	Waardenburg Syndrome	8.3%
232	Pseudohypoparathyroidism	7.9%
233	Xeroderma	7.8%
234	Mobius Syndrome	7.8%
235	Rickets	7.6%
236	Scimitar Syndrome	7.3%
237	Mastoiditis	7.2%
238	Petrositis	7.2%
239	Genetic Diseases, Inborn	7.2%
240	Alstrom Syndrome	7.2%
241	MELAS Syndrome	7.1%
242	Anophthalmos	7%
243	Anus, Imperforate	7%
244	Hydranencephaly	7%
245	Microphthalmos	7%
246	Neural Tube Defects	7%
247	Tethered Cord Syndrome	7%
248	Iniencephaly	7%
249	Craniorachischisis	7%
250	Exencephaly	7%
251	Septo-Optic Dysplasia	7%
252	Cortical Dysplasia	7%
253	Malformations of Cortical Development	7%
254	Anorectal Malformations	7%
255	Bloom Syndrome	6.9%
256	Abnormalities, Radiation-Induced	6.8%
257	Polycystic Kidney Diseases	6.8%
258	Williams Syndrome	6.8%
259	Fragile X Syndrome	6.7%
260	Turner Syndrome	6.6%
261	Classical Lissencephalies and Subcortical Band Heterotopias	6.4%
262	Osteomalacia	6.3%
263	Retinal Dysplasia	6.2%
264	Ichthyosis, X-Linked	6.2%
265	Aniridia	6.2%
266	Epidermolysis Bullosa	6.1%
267	Fetal Diseases	6%
268	Smith-Lemli-Opitz Syndrome	6%
269	Blepharophimosis	6%
270	Laryngostenosis	6%
271	Mouth Abnormalities	6%
272	Esophageal Atresia	5.9%
273	Intestinal Atresia	5.9%
274	Horseshoe Kidney	5.9%
275	Acrodermatitis	5.9%
276	Lymphangiectasis, Intestinal	5.9%
277	Gianotti-Crosti Syndrome	5.9%
278	Kearns-Sayre syndrome	5.9%
279	Primary Ciliary Dyskinesia	5.8%
280	Cystic Fibrosis	5.3%
281	Klinefelter Syndrome	5.3%
282	Choanal Atresia	5.3%
283	Tracheobronchomegaly	5.3%
284	Laryngocele	5.3%
285	Choledochal Cyst	5.2%
286	Hermaphroditism	5.2%
287	Disorders of Sex Development	5.2%
288	Cryptorchidism	5.2%
289	Hypospadias	5.2%
290	Central Nervous System Cysts	5.2%
291	Ectopia Cordis	5.1%
292	Meningomyelocele	5.1%
293	Spina Bifida	5.1%
294	Single umbilical artery	5.1%
295	Dandy-Walker Syndrome	5.1%
296	POEMS Syndrome	5.1%
297	Polycystic Kidney, Autosomal Dominant	5%
298	Radicular Cyst	5%
299	Sjogren-Larsson Syndrome	5%
300	Pseudoxanthoma Elasticum	5%
301	Nose Neoplasms	4.7%
302	Meconium Aspiration Syndrome	4.7%
303	Bladder Exstrophy	4.6%
304	Epispadias	4.6%
305	Xeroderma Pigmentosum	4.5%
306	Kallmann Syndrome	4.5%
307	Multicystic Dysplastic Kidney	4.5%
308	Renal Osteodystrophy	4.5%
309	Renal rickets	4.5%
310	Hyperkeratosis, Epidermolytic	4.5%
311	Charcot-Marie-Tooth Disease	4.5%
312	Aortic coarctation	4.4%
313	Cor Triatriatum	4.4%
314	Coronary Vessel Anomalies	4.4%
315	Dental Enamel Hypoplasia	4.4%
316	Patent ductus arteriosus	4.4%
317	Ebstein Anomaly	4.4%
318	Heart Septal Defects	4.4%
319	Hypodontia	4.4%
320	Macrostomia	4.4%
321	Meningocele	4.4%
322	Microstomia	4.4%
323	Tetralogy of Fallot	4.4%
324	Transposition of Great Vessels	4.4%
325	Hypoplastic Left Heart Syndrome	4.4%
326	May-Thurner Syndrome	4.4%
327	Encephalocele	4.4%
328	Wolff-Parkinson-White Syndrome	4.3%
329	Zellweger Syndrome	4.3%
330	Dermal Sinus	4.2%
331	Spina Bifida Cystica	4.2%
332	Spina Bifida Occulta	4.2%
333	Lissencephaly	4.2%
334	Polymicrogyria	4.2%
335	Pachygyria	4.2%
336	Schizencephaly	4.2%
337	Periventricular Nodular Heterotopia	4.2%
338	Abdominal Cramps	4.2%
339	Amniotic Band Syndrome	4.2%
340	Asphyxia Neonatorum	4.2%
341	Infant, Premature, Diseases	4.2%
342	Infantile Colic	4.2%
343	Hyperandrogenism	4.1%
344	Tuberous Sclerosis	4.1%
345	Refsum Disease	4%
346	Long QT Syndrome	3.8%
347	Tricuspid Atresia	3.8%
348	Arrhythmogenic Right Ventricular Dysplasia	3.8%
349	Gonadal Dysgenesis	3.8%
350	Adrenogenital Syndrome	3.8%
351	Ovotesticular Disorders of Sex Development	3.8%
352	Familial Hypophosphatemic Rickets	3.8%
353	Aortopulmonary Septal Defect	3.6%
354	Double Outlet Right Ventricle	3.6%
355	Endocardial Cushion Defects	3.6%
356	Neoplastic Syndromes, Hereditary	3.6%
357	Myocardial bridging	3.6%
358	Aorticopulmonary Septal Defect	3.6%
359	Anemia, Neonatal	3.5%
360	Pelger-Huet Anomaly	3.5%
361	Persistent Fetal Circulation Syndrome	3.5%
362	Werner Syndrome	3.5%
363	Myasthenic Syndromes, Congenital	3.5%
364	Umbilical hernia	3.5%
365	Anemia, Sickle Cell	3.4%
366	Thalassemia	3.4%
367	Albinism	3.4%
368	Truncus Arteriosus, Persistent	3.2%
369	Romano-Ward Syndrome	3.1%
370	Neonatal Abstinence Syndrome	3%
371	Mucopolysaccharidosis II	3%
372	Fetal Growth Retardation	3%
373	Fetal Hypoxia	3%
374	Congenital nystagmus	3%
375	Fetal Alcohol Spectrum Disorders	3%
376	Toxoplasmosis, Congenital	2.9%
377	Syphilis, Congenital	2.9%
378	Rett Syndrome	2.9%
379	Menkes Kinky Hair Syndrome	2.8%
380	Familial Mediterranean Fever	2.8%
381	Wiskott-Aldrich Syndrome	2.7%
382	Autoimmune Lymphoproliferative Syndrome	2.6%
383	Congenital Hyperinsulinism	2.6%
384	Chorioamnionitis	2.6%
385	Angioedemas, Hereditary	2.6%
386	Sickle Cell Trait	2.5%
387	Arteriovenous fistula	2.5%
388	Neuronal Ceroid-Lipofuscinoses	2.4%
389	Adrenoleukodystrophy	2.4%
390	Paralysis, Obstetric	2.3%
391	Retinopathy of Prematurity	2.3%
392	Amino Acid Metabolism, Inborn Errors	2.3%
393	Carbohydrate Metabolism, Inborn Errors	2.3%
394	Metal Metabolism, Inborn Errors	2.3%
395	Progeria	2.3%
396	Lysosomal Storage Diseases	2.3%
397	Cytochrome-c Oxidase Deficiency	2.3%
398	Peroxisomal Disorders	2.3%
399	Bronchopulmonary Dysplasia	2.3%
400	Hepatolenticular Degeneration	2.2%
401	Fabry Disease	2.2%
402	Denys-Drash Syndrome	2.1%
403	Amyloid Neuropathies, Familial	2.1%
404	Glycogen storage disease type II	2%
405	Acute Chest Syndrome	2%
406	Ophthalmia Neonatorum	2%
407	Respiratory Distress Syndrome, Newborn	2%
408	Galactosemias	2%
409	Urea Cycle Disorders, Inborn	2%
410	Tyrosinemias	2%
411	Hydrops Fetalis	2%
412	Cutis Laxa	2%
413	Retinitis Pigmentosa	2%
414	Pigmentary retinopathy	2%
415	Porokeratosis	2%
416	Keratoderma, Palmoplantar	2%
417	Chronic granulomatous disease	2%
418	Ataxia Telangiectasia	1.9%
419	Mucopolysaccharidosis III	1.8%
420	Optic Atrophy, Hereditary, Leber	1.8%
421	Hyperphosphaturia	1.8%
422	Canavan Disease	1.8%
423	Alexander Disease	1.8%
424	Duane Retraction Syndrome	1.7%
425	Porphyrias, Hepatic	1.7%
426	Alkaptonuria	1.7%
427	Glycogen Storage Disease	1.7%
428	Hypophosphatasia	1.7%
429	Propionic acidemia	1.7%
430	Dihydropyrimidine Dehydrogenase Deficiency	1.7%
431	Cystinosis	1.7%
432	Peutz-Jeghers Syndrome	1.7%
433	Thrombasthenia	1.7%
434	Antithrombin III Deficiency	1.7%
435	Protein C Deficiency	1.7%
436	Brain Diseases, Metabolic, Inborn	1.7%
437	Afibrinogenemia	1.7%
438	Dystonia Musculorum Deformans	1.7%
439	Factor VII Deficiency	1.7%
440	Factor X Deficiency	1.7%
441	Factor XII Deficiency	1.7%
442	Hemophilia A	1.7%
443	Leukomalacia, Periventricular	1.7%
444	Activated Protein C Resistance	1.7%
445	Factor II deficiency	1.7%
446	Factor VIII Deficiency	1.7%
447	Factor V deficiency	1.7%
448	Factor XI Deficiency	1.7%
449	Hypoprothrombinemias	1.7%
450	Gaucher Disease	1.7%
451	Fanconi Anemia	1.7%
452	Nesidioblastosis	1.7%
453	Lafora Disease	1.7%
454	Unverricht-Lundborg Syndrome	1.7%
455	Anemia, Diamond-Blackfan	1.7%
456	Homocystinuria	1.7%
457	Leigh Disease	1.7%
458	Multiple Endocrine Neoplasia	1.6%
459	Tay-Sachs Disease	1.5%
460	Dermatitis, Atopic	1.5%
461	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.5%
462	Niemann-Pick Disease, Type C	1.5%
463	Hyaline Membrane Disease	1.5%
464	Hypolipoproteinemias	1.4%
465	Papillon-Lefevre Disease	1.4%
466	Hyperlipidemia, Familial Combined	1.4%
467	Hyperlipoproteinemia Type III	1.4%
468	Glycogen Storage Disease Type I	1.4%
469	Glycogen Storage Disease Type V	1.4%
470	Kernicterus	1.4%
471	Behcet Syndrome	1.4%
472	Lactose Intolerance	1.3%
473	Variegate Porphyria	1.3%
474	Acute intermittent porphyria	1.3%
475	Porphyria Cutanea Tarda	1.3%
476	Hyperhomocysteinemia	1.3%
477	Renal Aminoacidurias	1.3%
478	Fanconi Syndrome	1.3%
479	Pseudohypoaldosteronism	1.3%
480	Liddle Syndrome	1.3%
481	Hyperlipoproteinemia Type IV	1.3%
482	Hyperlipoproteinemia Type V	1.3%
483	Huntington Disease	1.2%
484	Hypoalphalipoproteinemias	1.2%
485	Multiple Endocrine Neoplasia Type 1	1.1%
486	Friedreich Ataxia	1.1%
487	Nephroblastoma	1.1%
488	Renal tubular acidosis	1.1%
489	Cystinuria	1%
490	Adenomatous Polyposis Coli	1%
491	Glycosuria, Renal	0.9%

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