MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Prehypertension

(UMLS:C1696708)

Definition:: Blood pressure levels that are between normotension and hypertension. Individuals with prehypertension are at a higher risk for developing cardiovascular diseases. Generally, prehypertension is defined as SYSTOLIC PRESSURE of 131-139 mm Hg and/or DIASTOLIC PRESSURE of 81-89 when the optimal is 120/80 mm Hg. For diabetics and other metabolism diseases the prehypertension is around 110-129/70-79 mm Hg.
UMLS ID:: C1696708
MeSH ID:: D058246

Classification:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.653

Synonym(s)

Prehypertension

prehypertension

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Aripiprazole	FAERS: 2	US FAERS
2	NuvaRing	FAERS: 2	US FAERS
3	Duloxetine Hydrochloride	FAERS: 1	US FAERS
4	Estrogens, Conjugated (USP)	FAERS: 1	US FAERS
5	Finasteride	FAERS: 1	US FAERS
6	Fingolimod Hydrochloride	FAERS: 1	US FAERS
7	Methylprednisolone Hemisuccinate	FAERS: 1	US FAERS
8	dolutegravir	FAERS: 1	US FAERS
9	testosterone 17 beta-cypionate	FAERS: 1	US FAERS
10	cabozantinib		SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Aneurysm	42.9%
2	Angiomatosis	42.9%
3	Aortic Diseases	42.9%
4	Arterial Occlusive Diseases	42.9%
5	Hyperemia	42.9%
6	Hypotension	42.9%
7	Superior Vena Cava Syndrome	42.9%
8	Telangiectasis	42.9%
9	Vasculitis	42.9%
10	Venous Insufficiency	42.9%
11	Peripheral Vascular Diseases	42.9%
12	Embolism and Thrombosis	42.9%
13	Angiodysplasia	42.9%
14	Capillary Leak Syndrome	42.9%
15	Aortic Aneurysm	40.9%
16	Aortitis	40.9%
17	Leriche Syndrome	40.9%
18	Periphlebitis	40.9%
19	Phlebitis	40.9%
20	Thromboangiitis Obliterans	40.9%
21	Myocardial Ischemia	38.1%
22	Postphlebitic Syndrome	37.1%
23	Thrombophlebitis	35.8%
24	Blue Toe Syndrome	34.3%
25	Aortic Aneurysm, Abdominal	33.3%
26	Aortic Aneurysm, Thoracic	33.3%
27	Retinal Vein Occlusion	32.5%
28	Coronary Aneurysm	31.7%
29	Aneurysm, Dissecting	31%
30	Arteriosclerosis	31%
31	Arteritis	31%
32	Embolism	31%
33	Erythromelalgia	31%
34	Fibromuscular Dysplasia	31%
35	Malignant Hypertension	31%
36	Raynaud Disease	31%
37	Thromboembolism	31%
38	Thrombosis	31%
39	Essential Hypertension	31%
40	Aneurysm, Ruptured	31%
41	Iliac Aneurysm	31%
42	Pulmonary artery stenosis	31%
43	White Coat Hypertension	31%
44	Systemic Vasculitis	31%
45	Embolus	31%
46	Malignant Atrophic Papulosis	30.5%
47	Shwartzman Phenomenon	30.3%
48	Aortic Rupture	30.2%
49	Vascular System Injuries	30%
50	Coronary Thrombosis	28.9%
51	Coronary Artery Disease	28.9%
52	Compartment syndromes	28.6%
53	Hepatic Veno-Occlusive Disease	28.6%
54	Peliosis Hepatis	28.6%
55	Varicocele	28.6%
56	Carotid Artery Thrombosis	28.4%
57	Cerebrovascular Disorders	27.9%
58	Diabetic Angiopathies	27.9%
59	Reperfusion Injury	27.9%
60	Splenic Infarction	27.9%
61	Cerebrovascular Insufficiency	27.9%
62	Vascular Neoplasms	27.9%
63	Spinal Cord Vascular Diseases	27.9%
64	Vasoplegia	27.9%
65	Hemorrhoids	27.6%
66	Thoracic Outlet Syndrome	27.6%
67	Intracranial Embolism and Thrombosis	27.5%
68	Carotid Stenosis	27.4%
69	Intracranial Aneurysm	27.4%
70	Coronary heart disease	27.3%
71	Myocardial Infarction	27.3%
72	Acute Coronary Syndrome	27.3%
73	Myocardial Reperfusion Injury	26.8%
74	Arteriosclerosis Obliterans	25.4%
75	Atherosclerosis	25.4%
76	Air Embolism	25.4%
77	Endarteritis	25.4%
78	Venous Thrombosis	25.4%
79	Deep Vein Thrombosis	25.4%
80	Venous Thromboembolism	25.4%
81	Moyamoya Disease	25.3%
82	Polyarteritis Nodosa	25%
83	Takayasu Arteritis	25%
84	Intracranial Arteriosclerosis	24.7%
85	Cerebral Atherosclerosis	24.7%
86	Cerebral Arteriosclerosis	24.7%
87	Cerebral Thrombosis	23.4%
88	Intracranial Embolism	23.4%
89	Intracranial Thrombosis	23.4%
90	Heart Diseases	23.1%
91	Coronary Occlusion	22.2%
92	Microvascular Angina	22.2%
93	Coronary Stenosis	22.2%
94	ST segment elevation myocardial infarction	22.2%
95	Hand-Arm Vibration Syndrome	21.8%
96	Arteriovenous fistula	21.6%
97	Sinus Thrombosis, Intracranial	21.3%
98	Optic Neuropathy, Ischemic	21.1%
99	Anterior Ischemic Optic Neuropathy	21.1%
100	Mesenteric vascular insufficiency	21.1%
101	Retinal Artery Occlusion	20.9%
102	Retinal Vasculitis	20.9%
103	Hypertensive Retinopathy	20.9%
104	Kounis Syndrome	20.7%
105	Anterior Compartment Syndrome	20.5%
106	Vasculitis, Leukocytoclastic, Cutaneous	20.5%
107	Gastric Antral Vascular Ectasia	20.5%
108	Abdominal Compartment Syndrome	20.5%
109	Cavernous Sinus Thrombosis	20.3%
110	Sagittal Sinus Thrombosis	20.3%
111	Angioedema	20.3%
112	Vasculitis, Central Nervous System	20.3%
113	Colitis, Ischemic	20.3%
114	Carotid Artery Diseases	20.2%
115	Brain Ischemia	20.2%
116	Hypotension, Orthostatic	20.2%
117	Cerebrovascular accident	20.2%
118	Varicose Ulcer	20.2%
119	Vasospasm, Intracranial	20.2%
120	Spinal Cord Ischemia	20.2%
121	Intracranial Arterial Diseases	20.2%
122	Primary Graft Dysfunction	20.2%
123	Post-Exercise Hypotension	20.2%
124	May-Thurner Syndrome	20.2%
125	Angina Pectoris	20.1%
126	Coronary Restenosis	19.8%
127	Embolism, Amniotic Fluid	19.7%
128	Brain Infarction	19.6%
129	Lemierre Syndrome	18.9%
130	Giant Cell Arteritis	18.5%
131	Temporal Arteritis	18.5%
132	Infarction, Middle Cerebral Artery	17.8%
133	Infarction, Anterior Cerebral Artery	17.8%
134	Infarction, Posterior Cerebral Artery	17.8%
135	Cerebral Infarction	17.5%
136	Brain Stem Infarctions	17.5%
137	Intermittent Claudication	17.2%
138	Pulmonary Embolism	17.2%
139	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	17.2%
140	Subarachnoid Hemorrhage, Traumatic	17%
141	Carotid Artery, Internal, Dissection	17%
142	No-Reflow Phenomenon	16.9%
143	Shock, Cardiogenic	16.7%
144	Cerebral Arterial Diseases	16.6%
145	Vertebrobasilar Insufficiency	16.6%
146	Anterior Spinal Artery Syndrome	16.6%
147	Basilar Artery Stenosis	16.6%
148	Vertebral Artery Stenosis	16.6%
149	Intracranial Hemorrhage, Hypertensive	16.6%
150	Transient Cerebral Ischemia	16.6%
151	Vertebral Artery Dissection	16.5%
152	Angina, Unstable	16.4%
153	Lateral Medullary Syndrome	16.4%
154	Mesenteric Vascular Occlusion	15.5%
155	Mucocutaneous Lymph Node Syndrome	15.5%
156	CREST Syndrome	15.5%
157	Hepatic Vein Thrombosis	15.4%
158	Budd-Chiari Syndrome	15.4%
159	Diabetic Retinopathy	15.4%
160	Sturge-Weber Syndrome	15.4%
161	Livedo Reticularis	15.3%
162	Renal hypertension	15.1%
163	Renal Artery Obstruction	15.1%
164	Renal Artery Stenosis	15.1%
165	Pulmonary Infarction	15.1%
166	Hemangioma, Cavernous	15%
167	Pregnancy Complications, Cardiovascular	15%
168	Cardiovascular Abnormalities	15%
169	Basal Ganglia Cerebrovascular Disease	15%
170	Vascular Headaches	14.9%
171	Scurvy	14.9%
172	Subclavian Steal Syndrome	14.8%
173	Scimitar Syndrome	14.8%
174	Angina Pectoris, Variant	14.6%
175	Cardiac Tamponade	14.3%
176	Endocarditis	14.3%
177	Cardiac Arrest	14.3%
178	Heart failure	14.3%
179	Pericardial effusion	14.3%
180	Pericarditis	14.3%
181	Pneumopericardium	14.3%
182	Cor pulmonale	14.3%
183	Ventricular Outflow Obstruction	14.3%
184	Ventricular Dysfunction	14.3%
185	Cardiomyopathies	14.3%
186	Pleuropericarditis	14.3%
187	Carotid Artery Injuries	14.1%
188	Aortic Valve Stenosis	13.6%
189	Cardiomyopathy, Dilated	13.6%
190	Pulmonary Valve Stenosis	13.6%
191	Basal Ganglia Hemorrhage	13.1%
192	Hypertension, Renovascular	12.3%
193	Subarachnoid Hemorrhage	12.3%
194	Hypoxia-Ischemia, Brain	12.3%
195	Cerebral Hemorrhage	12.3%
196	Hereditary Angioedema Type III	12.2%
197	Hereditary Angioedema Types I and II	12.2%
198	Ischemic contracture	12.2%
199	Angioedemas, Hereditary	12.1%
200	Tricuspid Atresia	12.1%
201	Arrhythmogenic Right Ventricular Dysplasia	12.1%
202	Putaminal Hemorrhage	12%
203	Cryoglobulinemia	12%
204	Leukomalacia, Periventricular	12%
205	Diabetic Foot	11.9%
206	Hypertrophic Cardiomyopathy	11.7%
207	Hypertrophic obstructive cardiomyopathy	11.7%
208	Granulomatosis with polyangiitis	11.3%
209	Supravalvular aortic stenosis	11.1%
210	Lown-Ganong-Levine Syndrome	11.1%
211	Cerebral Amyloid Angiopathy	11%
212	Dementia, Vascular	11%
213	Aortic Valve Insufficiency	10.3%
214	Restrictive cardiomyopathy	10.3%
215	Endocardial Fibroelastosis	10.3%
216	Heart Rupture, Post-Infarction	10.3%
217	Mitral Valve Insufficiency	10.3%
218	Mitral Valve Stenosis	10.3%
219	Myocarditis	10.3%
220	Pericarditis, Constrictive	10.3%
221	Pulmonary Valve Insufficiency	10.3%
222	Tricuspid Valve Insufficiency	10.3%
223	Tricuspid Valve Stenosis	10.3%
224	Ventricular Dysfunction, Left	10.3%
225	Right Ventricular Dysfunction	10.3%
226	Endomyocardial Fibrosis	10.3%
227	Carditis	10.3%
228	Heart Failure, Systolic	10.3%
229	Heart Failure, Diastolic	10.3%
230	Heart Block	10.2%
231	Tachycardia	10.2%
232	Tachyarrhythmia	10.2%
233	Aortic coarctation	10.1%
234	Cor Triatriatum	10.1%
235	Coronary Vessel Anomalies	10.1%
236	Patent ductus arteriosus	10.1%
237	Ebstein Anomaly	10.1%
238	Heart Septal Defects	10.1%
239	Tetralogy of Fallot	10.1%
240	Transposition of Great Vessels	10.1%
241	Hypoplastic Left Heart Syndrome	10.1%
242	Pituitary Apoplexy	10%
243	Shy-Drager Syndrome	9.9%
244	Purpura, Hyperglobulinemic	9.9%
245	Bacterial Endocarditis	9.7%
246	Cardiac Output, High	9.5%
247	Myocardial Stunning	9.5%
248	Low Cardiac Output Syndrome	9.5%
249	Cardiomegaly	9.3%
250	Postpericardiotomy Syndrome	9.3%
251	Cardiac Hypertrophy	9.3%
252	Rheumatic Heart Disease	9.1%
253	Behcet Syndrome	8.6%
254	Waldenstrom Macroglobulinemia	8.6%
255	Multiple Myeloma	8.6%
256	Aortic Valve Prolapse	8.5%
257	Tricuspid Valve Prolapse	8.5%
258	Takotsubo Cardiomyopathy	8.5%
259	Rheumatoid Vasculitis	8.3%
260	Adams-Stokes Syndrome	8.3%
261	Atrioventricular Block	8.3%
262	Bundle-Branch Block	8.3%
263	Atrial Premature Complexes	8.3%
264	Sinoatrial Block	8.3%
265	Tachycardia, Paroxysmal	8.3%
266	Supraventricular tachycardia	8.3%
267	Tachycardia, Ventricular	8.3%
268	Wolff-Parkinson-White Syndrome	8.3%
269	Tachycardia, Reciprocating	8.3%
270	Aortopulmonary Septal Defect	8.2%
271	Double Outlet Right Ventricle	8.2%
272	Endocardial Cushion Defects	8.2%
273	Myocardial bridging	8.2%
274	Aorticopulmonary Septal Defect	8.2%
275	Sick Sinus Syndrome	8.2%
276	Lupus Vasculitis, Central Nervous System	8.2%
277	Dextrocardia	8.1%
278	Long QT Syndrome	8.1%
279	Ataxia Telangiectasia	7.6%
280	Pseudoxanthoma Elasticum	7.6%
281	Tachycardia, Atrioventricular Nodal Reentry	7.3%
282	Tachycardia, Ectopic Atrial	7.3%
283	Tachycardia, Ectopic Junctional	7.3%
284	Sinus Tachycardia	7.3%
285	Torsades de Pointes	7.3%
286	Accelerated Idioventricular Rhythm	7.3%
287	Truncus Arteriosus, Persistent	7.3%
288	Sinus Arrhythmia	6.8%
289	Atrial Fibrillation	6.8%
290	Atrial Flutter	6.8%
291	Edema, Cardiac	6.8%
292	Ventricular Fibrillation	6.8%
293	Ventricular Flutter	6.8%
294	Parasystole	6.8%
295	Paroxysmal atrial fibrillation	6.8%
296	Bradycardia	6.8%
297	Diabetic Cardiomyopathies	6.8%
298	Cardiomyopathy, Alcoholic	6.7%
299	Ectopia Cordis	6.7%
300	Sudden Cardiac Death	6.7%
301	Left Ventricular Hypertrophy	6.7%
302	Right Ventricular Hypertrophy	6.7%
303	Single umbilical artery	6.7%
304	Chagas Cardiomyopathy	6.7%
305	Romano-Ward Syndrome	6.6%
306	Hematoma, Subdural	6.3%
307	Hematoma, Epidural, Cranial	6.3%
308	Subacute Bacterial Endocarditis	6.1%
309	Hematoma, Subdural, Intracranial	5.9%
310	Hematoma, Subdural, Chronic	5.9%
311	Hematoma, Subdural, Acute	5.9%
312	Noonan Syndrome	5.8%
313	Sinus Arrest, Cardiac	5.6%
314	Brain Hemorrhage, Traumatic	5.5%
315	Carcinoid Heart Disease	5.3%
316	Marfan Syndrome	5.1%
317	Dyspnea, Paroxysmal	5%
318	MELAS Syndrome	4.9%
319	Dural Arteriovenous Fistula	4.1%
320	Fabry Disease	3.7%
321	Williams Syndrome	3%
322	Turner Syndrome	2.8%
323	Kartagener Syndrome	2.6%
324	Kearns-Sayre syndrome	1.8%

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