MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hyponatremia

(UMLS:C0020625)

Definition:: Deficiency of sodium in the blood; salt depletion. (Dorland, 27th ed)
UMLS ID:: C0020625
MeSH ID:: D007010

Classification:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.950.620

Synonym(s)

Hyponatremia

HYPONATRAEMIA

HYPONATREMIA

Hyponatraemia

Hyponatraemia, NOS

Hyponatraemic syndrome

Hyponatremia syndrome

Hyponatremia, NOS

Low blood sodium levels

10.

Sodium, decreased level

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Amantadine	19483487	CTD
2	Amiloride	11999238	CTD
3	Amiodarone	12000975 12013366 15189547	CTD
4	Amitriptyline	2807860 6975430 20672238	CTD
5	Azithromycin	9391684	CTD
6	Bendroflumethiazide	7331904 17452686	CTD
7	Bupropion	15643110	CTD
8	Buspirone	9179637	CTD
9	Carbamazepine	View details 2522601 3824622 3986730 6502170 7635859 10024990 16189283 17366352 17722479	CTD
10	Chlorothiazide	6635723	CTD
11	Chlorpropamide	View details 1421649 1814884 3865878 5029389 6842150 8928190	CTD
12	Chlorthalidone	3704734 8440286	CTD
13	Citalopram	View details 9179637 10835739 11217819 12006908 12075041 12243606 12503252 14726801 14728721 15641882 16816780 16997047 17092960 17163295 17189754 17202465 17541890	CTD
14	Clonidine	432171	CTD
15	Clozapine	8270589 16168026	CTD
16	Colchicine	405656	CTD
17	Cyclophosphamide	View details 4812765 7633237 16917917 19128924	CTD
18	Deamino Arginine Vasopressin	12614377 16168026 19836189	CTD
19	Demeclocycline	3932859 11937482	CTD
20	Desoxycorticosterone	6621246	CTD
21	Desvenlafaxine Succinate	24234943	CTD
22	Dianhydrogalactitol	3153241	CTD
23	Dinoprost	6407273	CTD
24	Doxycycline	7635859	CTD
25	Enalapril	View details 3022372 10835739 12087354 19685582	CTD
26	Ethacrynic Acid	5090186	CTD
27	Etoposide	1339077 20332701	CTD
28	Flecainide	17452686 19298558	CTD
29	Fludrocortisone	19834406	CTD
30	Fluorouracil	8526189	CTD
31	Fluoxetine	View details 2356883 7826497 8540575 8804257 10731855 11217819 16622573	CTD
32	Fluphenazine	20672238	CTD
33	Fluvoxamine	8804257 11195401 12086550	CTD
34	Foscarnet	18277595	CTD
35	Furosemide	View details 635611 657047 2486385 5090186 16633772	CTD
36	Glycerol	3919450	CTD
37	Haloperidol	487691	CTD
38	Hydralazine	635611	CTD
39	Hydrochlorothiazide	10835739 11483546 11999238	CTD
40	Hydrocortisone	14657545 17585086 17905062	CTD
41	Hydroxyurea	15103940	CTD
42	Ibuprofen	12614377	CTD
43	Ifosfamide	2261371 16174228 19542534	CTD
44	Imipramine	3769770 8306129	CTD
45	Indapamide	View details 8573958 11999238 12088485 18386633 18507554	CTD
46	Indomethacin	12632374	CTD
47	Isoproterenol	6621246	CTD
48	Itraconazole	12368705	CTD
49	Levetiracetam	15946344	CTD
50	Lorazepam	3140958	CTD
51	Mannitol	3919450 17333050 20804114	CTD
52	Melphalan	3153241 3965085	CTD
53	Mesna	2261371	CTD
54	Methyldopa	635611 3215114	CTD
55	Metolazone	635611	CTD
56	Mirtazapine	16997047	CTD
57	Mitomycin	1339077	CTD
58	N-Methyl-3,4-methylenedioxyamphetamine	12096147 15725376 27079619	CTD
59	ON 01910	23841031 26091808	CTD
60	Omeprazole	8769288 15741423 18410837	CTD
61	Oxcarbazepine	View details 1563340 1949275 11839425 12112108 12197457 14595500 16804276 19401271	CTD
62	Oxytocin	11871004	CTD
63	Paroxetine	View details 8540575 8804257 9018197 10443873 11322690 12086550 15633859 16633772 16958954 17197752 18842231	CTD
64	Phenelzine	2768546	CTD
65	Pregabalin	20108561	CTD
66	Propranolol	635611	CTD
67	Reboxetine	17965988	CTD
68	Resveratrol	25895148	CTD
69	Risperidone	9339885	CTD
70	Sertraline	8166325 8804257	CTD
71	Sodium Chloride	6407273 16633772	CTD
72	Spironolactone	4740303	CTD
73	Tacrolimus	14604289 20737184	CTD
74	Theophylline	8177851 12086552	CTD
75	Tolvaptan	26660633	CTD
76	Trazodone	1571643	CTD
77	Triamcinolone	20111051	CTD
78	Valproic Acid	7820967 20000866 20222501	CTD
79	Venlafaxine Hydrochloride	17189754	CTD
80	Vinblastine	3091246 7105387	CTD
81	Vincristine	View details 4356234 4974027 12051122 12368705	CTD
82	Vinorelbine	9876812 17989977	CTD
83	Voriconazole	20567873	CTD
84	Xipamide	12528327	CTD
85	amiloride, hydrochlorothiazide drug combination	620148 2506346	CTD
86	conivaptan	19542534	CTD
87	gemcitabine	20082116 26091808	CTD
88	palbociclib	21610706	CTD
89	reviparin	9365341	CTD
90	tanespimycin	20082116	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Hyperkalemia	46.7%
2	Hypernatremia	46.7%
3	Hypokalemia	46.7%
4	Hypercalcemia	44.4%
5	Hypocalcemia	44.4%
6	Milk-Alkali Syndrome	44.4%
7	Dehydration	31.8%
8	Water Intoxication	31.8%
9	Acid-Base Imbalance	31%
10	Calcium Metabolism Disorders	31%
11	Iron Metabolism Disorders	31%
12	Phosphorus Metabolism Disorders	31%
13	Lipid Metabolism Disorders	31%
14	Mitochondrial Diseases	31%
15	Glucose Metabolism Disorders	31%
16	Wasting Syndrome	27.9%
17	Osteopenia	20.9%
18	Brain Diseases, Metabolic	20.5%
19	Acidosis	20%
20	Alkalosis	20%
21	Amyloidosis	20%
22	Calcinosis	20%
23	Hyperglycemia	20%
24	Hyperinsulinism	20%
25	Hypoglycemia	20%
26	Lipodystrophy	20%
27	Xanthomatosis	20%
28	Hypophosphatemia	20%
29	Metabolic acidosis	20%
30	Dyslipidemias	20%
31	Iron Overload	20%
32	Xanthoma	20%
33	Nutrition Disorders	18.5%
34	Pseudohypoparathyroidism	18.1%
35	Rickets	17.3%
36	Brain Diseases, Metabolic, Inborn	15.9%
37	Leigh Disease	15.2%
38	Hyperhomocysteinemia	15.1%
39	Acidosis, Lactic	14.8%
40	Calciphylaxis	14.8%
41	Hemosiderosis	14.8%
42	Ketosis	14.8%
43	Ketonuria	14.8%
44	Ketoacidosis	14.8%
45	Ketonemia	14.8%
46	Vascular calcification	14.8%
47	Hypolipoproteinemias	14.6%
48	Hyperlipoproteinemia Type IV	14.5%
49	Hyperlipoproteinemia Type V	14.5%
50	Diabetes Mellitus	14.3%
51	Carbamoyl-Phosphate Synthase I Deficiency Disease	13.8%
52	Lactose Intolerance	13.7%
53	Lipomatosis	13.6%
54	Werner Syndrome	13.6%
55	Diabetic Ketoacidosis	13.5%
56	Hyperlipidemia, Familial Combined	13.4%
57	Achlorhydria	13.3%
58	Amino Acid Metabolism, Inborn Errors	13.3%
59	Bloom Syndrome	13.3%
60	Carbohydrate Metabolism, Inborn Errors	13.3%
61	Metal Metabolism, Inborn Errors	13.3%
62	Osteoporosis	13.3%
63	Progeria	13.3%
64	Lysosomal Storage Diseases	13.3%
65	Bone Demineralization, Pathologic	13.3%
66	Cytochrome-c Oxidase Deficiency	13.3%
67	Peroxisomal Disorders	13.3%
68	Post-Traumatic Osteoporosis	13.3%
69	Celiac Disease	13.2%
70	Sprue, Tropical	13.2%
71	Steatorrhea	13.2%
72	Sprue	13.2%
73	Osteomalacia	13%
74	Hyperlipoproteinemia Type III	12.7%
75	Smith-Lemli-Opitz Syndrome	12.6%
76	Galactosemias	12.5%
77	Urea Cycle Disorders, Inborn	12.5%
78	Tyrosinemias	12.5%
79	Hypercholesterolemia	12.2%
80	Hyperlipoproteinemias	12.2%
81	Hypertriglyceridemia	12.2%
82	Congenital Hyperinsulinism	12.2%
83	Hypoalphalipoproteinemias	12%
84	Familial Hypophosphatemic Rickets	11.5%
85	Mitochondrial Encephalomyopathies	11.5%
86	Gaucher Disease	10.9%
87	Hyperphosphaturia	10.9%
88	Glycogen storage disease type II	10.6%
89	Homocystinuria	10.4%
90	Child Nutrition Disorders	10.3%
91	Hypervitaminosis A	10.3%
92	Infant Nutrition Disorders	10.3%
93	Malnutrition	10.3%
94	Mitochondrial Myopathies	10.2%
95	Myelinolysis, Central Pontine	10.1%
96	Glycosuria	9.9%
97	Reye Syndrome	9.9%
98	Acidosis, Respiratory	9.9%
99	Adiposis Dolorosa	9.9%
100	Alkalosis, Respiratory	9.9%
101	Hepatic Encephalopathy	9.8%
102	Tay-Sachs Disease	9.8%
103	Nesidioblastosis	9.8%
104	Alkaptonuria	9.8%
105	Glycogen Storage Disease	9.8%
106	Hypophosphatasia	9.8%
107	Insulin Resistance	9.8%
108	Osteoporosis, Postmenopausal	9.8%
109	Propionic acidemia	9.8%
110	Dihydropyrimidine Dehydrogenase Deficiency	9.8%
111	Cystinosis	9.8%
112	Amyloid Neuropathies, Familial	9.8%
113	Renal tubular acidosis	9.7%
114	Niemann-Pick Disease, Type C	9.3%
115	Neuronal Ceroid-Lipofuscinoses	9%
116	HIV Wasting Syndrome	8.8%
117	Fabry Disease	8.5%
118	HIV-Associated Lipodystrophy Syndrome	8.4%
119	MELAS Syndrome	8.2%
120	Renal Osteodystrophy	8.2%
121	Renal rickets	8.2%
122	Porphyrias, Hepatic	8.1%
123	Glycogen Storage Disease Type I	8.1%
124	Glycogen Storage Disease Type V	8.1%
125	Zellweger Syndrome	8%
126	Mucopolysaccharidosis III	8%
127	Adrenoleukodystrophy	8%
128	Necrobiosis Lipoidica Diabeticorum	7.9%
129	Menkes Kinky Hair Syndrome	7.9%
130	Fanconi Anemia	7.8%
131	Wernicke Encephalopathy	7.7%
132	Gestational Diabetes	7.7%
133	Latent Autoimmune Diabetes in Adults	7.7%
134	Diabetes Mellitus, Experimental	7.6%
135	Hepatolenticular Degeneration	7.4%
136	Nephrocalcinosis	7.4%
137	Tetany	7.4%
138	Refsum Disease	7.3%
139	Glycosuria, Renal	7.3%
140	Cerebral Amyloid Angiopathy	7.2%
141	Deficiency Diseases	6.7%
142	Starvation	6.7%
143	Refeeding Syndrome	6.7%
144	Friedreich Ataxia	6.5%
145	Familial Periodic Paralysis	6%
146	Primary amyloidosis	6%
147	Variegate Porphyria	5.9%
148	Acute intermittent porphyria	5.9%
149	Porphyria Cutanea Tarda	5.9%
150	Renal Aminoacidurias	5.8%
151	Fanconi Syndrome	5.8%
152	Pseudohypoaldosteronism	5.8%
153	Liddle Syndrome	5.8%
154	Kernicterus	5.7%
155	Kearns-Sayre syndrome	5.7%
156	Cockayne Syndrome	5.7%
157	Canavan Disease	5.4%
158	Alexander Disease	5.4%
159	Sjogren-Larsson Syndrome	5.4%
160	Mucopolysaccharidosis II	5.3%
161	Ataxia Telangiectasia	5.1%
162	Gout	5%
163	Amyotrophic Lateral Sclerosis	5%
164	Kwashiorkor	4.9%
165	Magnesium Deficiency	4.9%
166	Potassium Deficiency	4.9%
167	Protein Deficiency	4.9%
168	Avitaminosis	4.9%
169	Optic Atrophy, Hereditary, Leber	4.9%
170	Antley-Bixler Syndrome Phenotype	4.9%
171	Hypokalemic periodic paralysis	4.9%
172	Frontotemporal dementia	4.8%
173	Cystinuria	4.8%
174	Xeroderma Pigmentosum	4.5%
175	CREST Syndrome	4.2%
176	Ascorbic Acid Deficiency	4.1%
177	Vitamin A Deficiency	4.1%
178	Vitamin D Deficiency	4.1%
179	Vitamin E Deficiency	4.1%
180	Marasmus	4.1%
181	Arthritis, Gouty	4.1%
182	Albinism	3.7%
183	Folic Acid Deficiency	3.6%
184	Pellagra	3.6%
185	Thiamine Deficiency	3.6%
186	Vitamin B 12 Deficiency	3.6%
187	Vitamin B 6 Deficiency	3.6%
188	Pyridoxine Deficiency	3.6%
189	Beriberi	3.4%
190	Ichthyosis, X-Linked	3%
191	Obesity	2.6%
192	Obesity, Abdominal	2.4%
193	Anemia, Pernicious	2.3%
194	Vitamin K Deficiency	2.1%
195	Pediatric Obesity	1.9%
196	Scurvy	1.8%
197	Prader-Willi Syndrome	1.6%
198	Subacute Combined Degeneration	1.2%

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