MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Neuromyelitis Optica

(UMLS:C0027873)

Definition:: A syndrome characterized by acute OPTIC NEURITIS; MYELITIS, TRANSVERSE; demyelinating and/or necrotizing lesions in the OPTIC NERVES and SPINAL CORD; and presence of specific autoantibodies to AQUAPORIN 4.
UMLS ID:: C0027873
MeSH ID:: D009471

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.114.375.600.500|C10.114.375.800|C10.292.700.550.500|C10.314.350.600.500|C10.314.350.800

Classification 2:

Name:

Eye Diseases
MeSH Tree Number(s):: C11.640.576.695

Classification 3:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.111.258.250.550.500|C20.111.258.250.775

Synonym(s)

Neuromyelitis Optica

DEVIC DISEASE

Devic

Devic Syndrome

Devic disease

Devic syndrome

Devic's disease

MYELITIS, OPTIC NEURITIS IN

NEUROENCEPHALOMYELOPATHY, OPTIC

10.

Neuromyelitis optica

11.

Neuromyelitis optica [Devic]

12.

Neuromyelitis optica spectrum disorder

13.

OPHTHALMONEUROMYELITIS

14.

Optic neuromyelitis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Fingolimod Hydrochloride	FAERS: 11		US FAERS
2	Dimethyl Fumarate	FAERS: 5		US FAERS
3	Carbamazepine	FAERS: 3		US FAERS
4	Glatiramer Acetate	FAERS: 3		OFFSIDES US FAERS
5	4-Aminopyridine	FAERS: 2		US FAERS
6	Zanamivir	FAERS: 2		US FAERS
7	Baclofen	FAERS: 1		OFFSIDES US FAERS
8	Bosentan	FAERS: 1		US FAERS
9	Cyclosporine	FAERS: 1		US FAERS
10	Desogestrel	FAERS: 1		US FAERS
11	Duloxetine Hydrochloride	FAERS: 1		US FAERS
12	Mycophenolic Acid	FAERS: 1		US FAERS
13	Mycophenolic Acid	FAERS: 1		US FAERS
14	Oxcarbazepine	FAERS: 1		US FAERS
15	Ruxolitinib phosphate	FAERS: 1		US FAERS
16	Sertraline	FAERS: 1		US FAERS
17	teriflunomide	FAERS: 1		US FAERS
18	Atomoxetine Hydrochloride			OFFSIDES
19	Bupivacaine		14582781	CTD
20	Famotidine			OFFSIDES
21	Ibandronic Acid			OFFSIDES
22	Imipramine			OFFSIDES
23	Medroxyprogesterone			OFFSIDES
24	Methylprednisolone		18509235	CTD
25	Mitoxantrone			OFFSIDES
26	Nitrofurantoin			OFFSIDES
27	Pravastatin			OFFSIDES
28	Vitamin B 12			OFFSIDES
29	alfacalcidol			OFFSIDES
30	efavirenz			OFFSIDES
31	eperisone			OFFSIDES
32	etizolam			OFFSIDES
33	geranylgeranylacetone			OFFSIDES
34	lamivudine, zidovudine drug combination			OFFSIDES
35	loxoprofen			OFFSIDES
36	pantethine			OFFSIDES
37	sennoside A&B			OFFSIDES
38	tizanidine			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Leukoencephalitis, Acute Hemorrhagic	62.8%
2	Multiple Sclerosis	50.7%
3	Encephalomyelitis, Acute Disseminated	48.9%
4	Polyradiculoneuropathy	41%
5	Polyradiculoneuritis	41%
6	Stiff-Person Syndrome	36.4%
7	Multiple Sclerosis, Chronic Progressive	35.8%
8	Multiple Sclerosis, Relapsing-Remitting	35.8%
9	Neuromyelitis Optica	35.2%
10	Myasthenia Gravis	31.3%
11	Myelitis, Transverse	30%
12	Myasthenia Gravis, Autoimmune, Experimental	28.6%
13	Lambert-Eaton Myasthenic Syndrome	28.6%
14	Guillain-Barre Syndrome	28.4%
15	Ophthalmoplegic Migraine	27.6%
16	Uveomeningoencephalitic Syndrome	27.4%
17	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	26.1%
18	Vasculitis, Central Nervous System	25.2%
19	Miller Fisher Syndrome	25%
20	Subacute Combined Degeneration	23.6%
21	Ocular Motility Disorders	22.7%
22	Cyclophoria	22.7%
23	Lupus Vasculitis, Central Nervous System	21.3%
24	Marchiafava-Bignami Disease	20%
25	Multiple System Atrophy	20%
26	Restless Legs Syndrome	19.4%
27	Neuritis, Autoimmune, Experimental	18.3%
28	Myelinolysis, Central Pontine	18.2%
29	Motor Neuron Disease	17.9%
30	Optic Atrophy	17.5%
31	Papilledema	17.5%
32	Neuromuscular Diseases	17.4%
33	Chronobiology Disorders	17.4%
34	Amyotrophic Lateral Sclerosis	17.2%
35	Leukoencephalopathy, Progressive Multifocal	17.1%
36	Progressive supranuclear palsy	17%
37	Opsoclonus-Myoclonus Syndrome	16.5%
38	Trauma, Nervous System	16%
39	Optic Neuropathy, Ischemic	16%
40	Anterior Ischemic Optic Neuropathy	16%
41	Nervous System Neoplasms	15.8%
42	Neurologic Manifestations	15.8%
43	Neurotoxicity Syndromes	15.8%
44	Meningoencephalitis	15.8%
45	Olfactory Nerve Injuries	15.8%
46	Lewy Body Disease	15.2%
47	Spinal Muscular Atrophy	15.2%
48	Progressive Muscular Atrophy	15.2%
49	Facial Nerve Injuries	14.6%
50	Sleep Wake Disorders	14.5%
51	Encephalomyelitis	14.5%
52	Prion Diseases	14.5%
53	Autonomic Dysreflexia	14.5%
54	Complex Regional Pain Syndromes	14.5%
55	Parkinson Disease	14.4%
56	Cranial nerve diseases	14.1%
57	Giant Cell Arteritis	14.1%
58	Temporal Arteritis	14.1%
59	Dandy-Walker Syndrome	14%
60	Pneumocephalus	13.9%
61	Poliomyelitis	13.9%
62	Striatonigral Degeneration	13.7%
63	Vagus Nerve Disorder	13.5%
64	Glossopharyngeal Neuralgia	13.5%
65	Abducens Nerve Diseases	13.5%
66	Trochlear Nerve Diseases	13.5%
67	Spinal Cord Injuries	13.4%
68	Canavan Disease	13.3%
69	Alexander Disease	13.3%
70	Peripheral Nerve Injuries	13.3%
71	Dyskinesia, Drug-Induced	13.2%
72	Asterixis	13.2%
73	Ballismus	13.2%
74	Optic Nerve Glioma	13.2%
75	Shy-Drager Syndrome	12.7%
76	Ophthalmoplegia	12.6%
77	External Ophthalmoplegia	12.6%
78	Epidural Abscess	12.5%
79	Chronic Fatigue Syndrome	12.4%
80	Sleep Disorders, Circadian Rhythm	12.3%
81	Facial Nerve Diseases	12.3%
82	MPTP Poisoning	12.2%
83	Vestibulocochlear Nerve Diseases	12.2%
84	Causalgia	12.1%
85	Botulism	12.1%
86	Central Nervous System Cysts	12.1%
87	Horner Syndrome	11.7%
88	Ataxia Telangiectasia	11.7%
89	Neuroleptic Malignant Syndrome	11.7%
90	Pupil Disorders	11.3%
91	Akathisia, Drug-Induced	11.2%
92	Dystonia Musculorum Deformans	11.2%
93	Myelitis	11.1%
94	Progressive bulbar palsy	11.1%
95	Bulbar palsy	11.1%
96	Huntington Disease	11%
97	Tuberous Sclerosis	11%
98	Antiphospholipid Syndrome	10.4%
99	Demyelinating Diseases	10.4%
100	Demyelination	10.4%
101	Limbic Encephalitis	10.3%
102	Vocal Cord Paralysis	10.2%
103	Brain Injuries	10.1%
104	Brain Neoplasms	10.1%
105	Spinal Cord Neoplasms	10.1%
106	Brain Diseases	9.9%
107	Dysautonomia	9.9%
108	Meningitis	9.9%
109	Movement Disorders	9.9%
110	Pachymeningitis	9.9%
111	Spinal Cord Diseases	9.9%
112	Heavy Metal Poisoning, Nervous System	9.9%
113	Neuromuscular Junction Diseases	9.9%
114	Tauopathies	9.9%
115	Peripheral Nervous System Diseases	9.9%
116	Jet Lag Syndrome	9.9%
117	Epilepsy, Post-Traumatic	9.7%
118	Duane Retraction Syndrome	9.7%
119	Charcot-Marie-Tooth Disease	9.6%
120	Amblyopia	9.6%
121	Strabismus	9.6%
122	Tolosa-Hunt Syndrome	9.6%
123	Hepatolenticular Degeneration	9.6%
124	Dementia, Vascular	9.6%
125	Brain Hemorrhage, Traumatic	9.5%
126	Reflex Sympathetic Dystrophy	9.5%
127	Subdural Effusion	9.5%
128	Parkinsonian Disorders	9.5%
129	Nocturnal Myoclonus Syndrome	9.5%
130	Lupus Erythematosus, Systemic	9.5%
131	Overlap syndrome	9.5%
132	Optic Atrophy, Hereditary, Leber	9.4%
133	Autoimmune Lymphoproliferative Syndrome	9.4%
134	Addison Disease	9.4%
135	Pemphigus	9.4%
136	Autoimmune thyroiditis	9.4%
137	Primary Adrenal Insufficiency	9.4%
138	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	9.4%
139	Autoimmune hepatitis	9.4%
140	Brain Abscess	9.3%
141	Adrenoleukodystrophy	9.1%
142	Central Nervous System Infection	9.1%
143	Myopathy	9.1%
144	Craniocerebral Trauma	9%
145	Parasomnia	9%
146	Dyssomnias	9%
147	Graves Disease	8.9%
148	Decerebrate State	8.9%
149	Hemiparesis	8.9%
150	Hydranencephaly	8.9%
151	Meningism	8.9%
152	Neural Tube Defects	8.9%
153	Paresis	8.9%
154	Seizures	8.9%
155	Sensation Disorders	8.9%
156	Tethered Cord Syndrome	8.9%
157	Central Nervous System Neoplasms	8.9%
158	Complex partial seizures	8.9%
159	Iniencephaly	8.9%
160	Craniorachischisis	8.9%
161	Exencephaly	8.9%
162	Monoparesis	8.9%
163	Septo-Optic Dysplasia	8.9%
164	Cortical Dysplasia	8.9%
165	Neurogenic Inflammation	8.9%
166	Gait Disorders, Neurologic	8.9%
167	Neuromuscular Manifestations	8.9%
168	Malformations of Cortical Development	8.9%
169	Sweating, Gustatory	8.9%
170	Auriculotemporal Syndrome	8.9%
171	Acoustic Neuroma	8.8%
172	Lafora Disease	8.7%
173	Unverricht-Lundborg Syndrome	8.7%
174	Scrapie	8.7%
175	Central Cord Syndrome	8.7%
176	Presenile dementia	8.6%
177	Senile dementia	8.6%
178	Meningitis, Bacterial	8.6%
179	Meningitis, Fungal	8.6%
180	Chorea	8.6%
181	Acrodynia	8.6%
182	Latent Autoimmune Diabetes in Adults	8.6%
183	Dermatitis Herpetiformis	8.5%
184	Myotonic Dystrophy	8.4%
185	Friedreich Ataxia	8.4%
186	Carotid Artery Injuries	8.4%
187	Cerebellar Neoplasms	8.4%
188	Autoimmune thrombocytopenia	8.3%
189	Immune thrombocytopenic purpura	8.3%
190	Neurobehavioral Manifestations	8.2%
191	Refsum Disease	8.2%
192	Vision Disorders	8.2%
193	Metamorphopsia	8.2%
194	Visual Impairment	8.2%
195	Paraneoplastic Encephalomyelitis	8.1%
196	Alstrom Syndrome	8.1%
197	Sturge-Weber Syndrome	8.1%
198	Vertigo	8.1%
199	Alcohol-Induced Disorders, Nervous System	8.1%
200	Alcohol Withdrawal Seizures	7.9%
201	Myotonia Congenita	7.9%
202	Paraneoplastic Cerebellar Degeneration	7.9%
203	Rheumatoid Arthritis	7.9%
204	Juvenile arthritis	7.9%
205	Cerebrospinal Fluid Otorrhea	7.9%
206	Cerebrospinal Fluid Rhinorrhea	7.9%
207	Gait Ataxia	7.9%
208	Meige Syndrome	7.8%
209	Brachial Plexus Neuritis	7.8%
210	Neuralgic Amyotrophy	7.8%
211	Cerebral Ventriculitis	7.8%
212	Anti-Glomerular Basement Membrane Disease	7.8%
213	Tuberculosis, Meningeal	7.7%
214	Facial Neuralgia	7.5%
215	Voice Disorders	7.5%
216	Voice Disturbance	7.5%
217	Vestibular Neuronitis	7.5%
218	Brain Death	7.5%
219	Coma, Post-Head Injury	7.5%
220	Alice in Wonderland Syndrome	7.5%
221	Smith-Magenis syndrome	7.4%
222	Dural Arteriovenous Fistula	7.4%
223	Optic Neuropathy	7.4%
224	Akathisia	7.3%
225	Restlessness	7.3%
226	Psychomotor Agitation	7.3%
227	Toxoplasmosis, Cerebral	7.3%
228	Low Tension Glaucoma	7.2%
229	Pituitary Adenoma	7.2%
230	Pituitary Neoplasms	7.2%
231	Brain Concussion	7.2%
232	Creutzfeldt-Jakob disease	7.1%
233	Basal Ganglia Cerebrovascular Disease	7.1%
234	Brain Injuries, Diffuse	7.1%
235	Traumatic Brain Injury	7.1%
236	Cerebellar Ataxia	7.1%
237	Supratentorial Neoplasms	7.1%
238	Torticollis	7.1%
239	Tarsal Tunnel Syndrome	7%
240	Cauda Equina Syndrome	7%
241	Posterior Leukoencephalopathy Syndrome	7%
242	Posterior reversible encephalopathy syndrome	7%
243	Facial Hemiatrophy	6.9%
244	Melkersson-Rosenthal Syndrome	6.9%
245	Anisocoria	6.9%
246	Tonic Pupil	6.9%
247	Reflex, Abnormal	6.8%
248	Hyporeflexia	6.8%
249	Hyperreflexia	6.8%
250	Kearns-Sayre syndrome	6.6%
251	Vertebral Artery Dissection	6.6%
252	Eye Injuries	6.6%
253	Amnesia, Transient Global	6.6%
254	Gait Apraxia	6.6%
255	Leukomalacia, Periventricular	6.5%
256	Esotropia	6.5%
257	Exotropia	6.5%
258	Hypersensitivity	6.5%
259	Immunologic Deficiency Syndromes	6.5%
260	Immunoproliferative Disorders	6.5%
261	Immune reconstitution syndrome	6.5%
262	Immune Reconstitution Inflammatory Syndrome	6.5%
263	Carpal Tunnel Syndrome	6.4%
264	Vascular Headaches	6.4%
265	neurofibroma	6.3%
266	Hypoxia-Ischemia, Brain	6.3%
267	Sciatica	6.3%
268	Tardive Dyskinesia	6.3%
269	Persistent Vegetative State	6.3%
270	Mobius Syndrome	6.3%
271	Bell Palsy	6.3%
272	Herpes Zoster Oticus	6.3%
273	Amyloid Neuropathies, Familial	6.3%
274	Basal Ganglia Hemorrhage	6.3%
275	Akinetic Mutism	6.2%
276	Anoxic Encephalopathy	6.2%
277	Arachnoiditis	6.2%
278	Basal Ganglia Diseases	6.2%
279	Brain Damage, Chronic	6.2%
280	Cerebellar Diseases	6.2%
281	Encephalitis	6.2%
282	Encephalomalacia	6.2%
283	Epilepsy	6.2%
284	Hydrocephalus	6.2%
285	Congenital Hydrocephalus	6.2%
286	Hypothalamic Diseases	6.2%
287	Aseptic Meningitis	6.2%
288	Neuritis	6.2%
289	Polyneuritis	6.2%
290	Radiculitis	6.2%
291	Syringomyelia	6.2%
292	Thalamic Diseases	6.2%
293	Intracranial Hypertension	6.2%
294	Polyneuropathy	6.2%
295	Mononeuritis	6.2%
296	Aura	6.2%
297	Leukoencephalopathy	6.2%
298	Essential Tremor	6.2%
299	Neuroaxonal Dystrophies	6.2%
300	Familial Tremor	6.2%
301	Headache Disorders	6.2%
302	Mononeuropathies	6.2%
303	Intracranial Hypotension	6.2%
304	Brachial Plexus Neuropathies	6.2%
305	Radiculopathy	6.2%
306	Mononeuropathy Multiplex	6.2%
307	Nerve Root Compression	6.2%
308	Brain Edema	6.2%
309	Brain Hypoxia	6.2%
310	Aqueductal Stenosis	6.2%
311	Pneumorrhachis	6.2%
312	Writer's Cramp	6.2%
313	Myoclonic Epilepsy	6.2%
314	Epilepsy, Temporal Lobe	6.2%
315	Epilepsy, Rolandic	6.2%
316	Benign Rolandic Epilepsy	6.2%
317	Subarachnoid Hemorrhage, Traumatic	6.1%
318	Carotid Artery, Internal, Dissection	6.1%
319	Mitochondrial Encephalomyopathies	6%
320	Color blindness	6%
321	Congenital nystagmus	6%
322	Subacute Sclerosing Panencephalitis	5.9%
323	Corneal Scar	5.9%
324	Transfusion Reaction	5.9%
325	Hypotensive Transfusion Reaction	5.9%
326	Meningitis, Cryptococcal	5.8%
327	Meningitis, Listeria	5.8%
328	Meningitis, Haemophilus	5.8%
329	Meningitis, Pneumococcal	5.8%
330	Frontotemporal dementia	5.8%
331	Brain Diseases, Metabolic	5.6%
332	Cerebrovascular Disorders	5.6%
333	Myositis	5.6%
334	Cerebrovascular Insufficiency	5.6%
335	Isaacs syndrome	5.6%
336	Arsenic Poisoning	5.6%
337	Dementia	5.6%
338	Myotonic Disorders	5.6%
339	Central Nervous System Fungal Infections	5.6%
340	Conus Medullaris Syndrome	5.6%
341	Myasthenic Syndromes, Congenital	5.6%
342	Spinal Cord Vascular Diseases	5.6%
343	Cubital Tunnel Syndrome	5.6%
344	Diffuse Axonal Injury	5.6%
345	Brain Stem Neoplasms	5.6%
346	Auditory Perceptual Disorders	5.6%
347	Diabetic Neuropathies	5.6%
348	Facial Injuries	5.6%
349	Diabetic Amyotrophy	5.6%
350	Diabetic Autonomic Neuropathy	5.6%
351	Sleep Talking	5.6%
352	Manganese Poisoning	5.6%
353	Sleep Disorders, Intrinsic	5.6%
354	Orthostatic intolerance	5.6%
355	Anosmia	5.5%
356	Ataxia	5.5%
357	Athetosis	5.5%
358	Catalepsy	5.5%
359	Dystonia	5.5%
360	Hemiplegia	5.5%
361	Locked-In Syndrome	5.5%
362	Meningeal Neoplasms	5.5%
363	Meningomyelocele	5.5%
364	Muscle Hypertonia	5.5%
365	Muscle hypotonia	5.5%
366	Myoclonus	5.5%
367	Myotonia	5.5%
368	Neuralgia	5.5%
369	Paraplegia	5.5%
370	Pseudobulbar Palsy	5.5%
371	Quadriplegia	5.5%
372	Spasm	5.5%
373	Spastic Paraplegia	5.5%
374	Status Epilepticus	5.5%
375	Taste Disorders	5.5%
376	Tremor	5.5%
377	Spina Bifida	5.5%
378	Monoplegia	5.5%
379	Hypokinesia	5.5%
380	Paraparesis	5.5%
381	Bradykinesia	5.5%
382	Waxy flexibility	5.5%
383	Action Tremor	5.5%
384	Resting Tremor	5.5%
385	Dysosmia	5.5%
386	Quadriparesis	5.5%
387	Mercury Poisoning, Nervous System	5.5%
388	Olfaction Disorders	5.5%
389	Myokymia	5.5%
390	Lead Poisoning, Nervous System	5.5%
391	Somatosensory Disorders	5.5%
392	Neuropathic pain	5.5%
393	Hyperkinesia	5.5%
394	Intention tremor	5.5%
395	Putaminal Hemorrhage	5.5%
396	Aicardi's syndrome	5.4%
397	MELAS Syndrome	5.4%
398	Infarction, Middle Cerebral Artery	5.4%
399	Infarction, Anterior Cerebral Artery	5.4%
400	Infarction, Posterior Cerebral Artery	5.4%
401	Orbital Myositis	5.4%
402	Diplopia	5.4%
403	Scotoma	5.4%
404	Photophobia	5.4%
405	Amaurosis	5.4%
406	Blindness	5.4%
407	Classical Lissencephalies and Subcortical Band Heterotopias	5.3%
408	Juvenile Myoclonic Epilepsy	5.3%
409	Myoclonic Epilepsies, Progressive	5.3%
410	Glomerulonephritis, Membranoproliferative	5.3%
411	Trigeminal Nerve Disorder	5.2%
412	Hand-Arm Vibration Syndrome	5.2%
413	Pituitary Apoplexy	5.2%
414	Brain Contusion	5.1%
415	Fibromyalgia	5.1%
416	Brain Infarction	5.1%
417	Central Nervous System Bacterial Infections	5.1%
418	Medial Tibial Stress Syndrome	5.1%
419	Mitochondrial Myopathies	5.1%
420	Confusion	5.1%
421	Facial paralysis	5.1%
422	Lethargy	5.1%
423	Memory Disorders	5.1%
424	Muscle Cramp	5.1%
425	Perceptual Disorders	5.1%
426	Psychomotor Disorders	5.1%
427	Eosinophilia-Myalgia Syndrome	5.1%
428	Anhedonia	5.1%
429	Disorientation	5.1%
430	Facial Paresis	5.1%
431	Memory Loss	5.1%
432	Hemisensory Neglect	5.1%
433	Dysacusis	5.1%
434	Sleep Bruxism	5.1%
435	Kernicterus	5.1%
436	Anencephaly	5.1%
437	Meningocele	5.1%
438	Muscular Atrophy	5.1%
439	Respiratory Paralysis	5.1%
440	Encephalocele	5.1%
441	Tetany	5%
442	Granulomatosis with polyangiitis	4.9%
443	West Nile Fever	4.9%
444	Choroid Plexus Papilloma	4.8%
445	Sicca Syndrome	4.8%
446	Sjogren's Syndrome	4.8%
447	POEMS Syndrome	4.8%
448	Hemianopsia	4.7%
449	Alexia	4.7%
450	Dyslexia	4.7%
451	Consciousness Disorders	4.7%
452	Mental Retardation	4.7%
453	Muscle Weakness	4.7%
454	Depressed Level of Consciousness	4.7%
455	Mental deficiency	4.7%
456	Intellectual Disability	4.7%
457	Hematoma, Subdural	4.7%
458	Hematoma, Epidural, Cranial	4.7%
459	Catatonia	4.7%
460	Familial Periodic Paralysis	4.7%
461	Aphonia	4.6%
462	Sleep Deprivation	4.6%
463	Dysphonia	4.6%
464	Retinal Dysplasia	4.6%
465	Optic Neuritis	4.6%
466	Felty Syndrome	4.5%
467	Lupus Nephritis	4.5%
468	Thrombocytopenic purpura	4.4%
469	Cerebral Infarction	4.4%
470	Brain Stem Infarctions	4.4%
471	Moyamoya Disease	4.4%
472	Corneal Perforation	4.4%
473	Neurofibrosarcoma	4.4%
474	AIDS Dementia Complex	4.4%
475	Cerebral Palsy	4.3%
476	Epilepsies, Partial	4.3%
477	Epilepsy, Generalized	4.3%
478	Pseudotumor Cerebri	4.3%
479	Sciatic Neuropathy	4.3%
480	Hypertensive Encephalopathy	4.3%
481	Ulnar Neuropathies	4.3%
482	Lesion of Sciatic Nerve	4.3%
483	Simple Partial Seizures	4.3%
484	Epilepsy, Reflex	4.3%
485	Ulnar Neuritis	4.3%
486	Radial nerve compression	4.3%
487	Radial Tunnel Syndrome	4.3%
488	Peroneal Neuropathies	4.3%
489	Radial Neuropathy	4.3%
490	Median Neuropathy	4.3%
491	Sciatic Nerve Palsy	4.3%
492	Femoral Neuropathy	4.3%
493	Tibial Neuropathy	4.3%
494	Ulnar Nerve Palsy	4.3%
495	Postural Orthostatic Tachycardia Syndrome	4.3%
496	Radial nerve palsy	4.3%
497	Headache Disorders, Primary	4.3%
498	Headache Disorders, Secondary	4.3%
499	Medication overuse headache	4.3%
500	Myalgia	4.3%
501	Neuronal Ceroid-Lipofuscinoses	4.3%
502	Rheumatoid Vasculitis	4.1%
503	Lateral Medullary Syndrome	4.1%
504	Aniridia	4.1%
505	Trigeminal Neuralgia	4.1%
506	Hoarseness	4%
507	Pituitary Diseases	4%
508	Cockayne Syndrome	4%
509	Amaurosis Fugax	4%
510	Blindness, Cortical	4%
511	Retinal Degeneration	4%
512	Alcohol Withdrawal Delirium	4%
513	Thoracic Outlet Syndrome	3.9%
514	Hematoma, Subdural, Intracranial	3.9%
515	Hematoma, Subdural, Chronic	3.9%
516	Hematoma, Subdural, Acute	3.9%
517	Carotid Artery Diseases	3.9%
518	Brain Ischemia	3.9%
519	Hypotension, Orthostatic	3.9%
520	Sleep Apnea Syndromes	3.9%
521	Cerebrovascular accident	3.9%
522	Polymyositis	3.9%
523	Kluver-Bucy Syndrome	3.9%
524	Vasospasm, Intracranial	3.9%
525	Spinal Cord Ischemia	3.9%
526	Intracranial Arterial Diseases	3.9%
527	Post-Exercise Hypotension	3.9%
528	Disorders of Excessive Somnolence	3.9%
529	Sleep Initiation and Maintenance Disorders	3.9%
530	Night Terrors	3.9%
531	Somnambulism	3.9%
532	Transient Insomnia	3.9%
533	Sleep Paralysis	3.9%
534	Chronic Insomnia	3.9%
535	REM Sleep Behavior Disorder	3.9%
536	Hypersomnia	3.9%
537	Dermal Sinus	3.9%
538	Dysgeusia	3.9%
539	Formication	3.9%
540	Hyperalgesia	3.9%
541	Hyperesthesia	3.9%
542	Hypesthesia	3.9%
543	Language Disorders	3.9%
544	Numbness	3.9%
545	Paresthesia	3.9%
546	Paraparesis, Spastic	3.9%
547	Spina Bifida Cystica	3.9%
548	Trismus	3.9%
549	Spina Bifida Occulta	3.9%
550	Epilepsia Partialis Continua	3.9%
551	Hypogeusia	3.9%
552	Meningeal Carcinomatosis	3.9%
553	Brown-Sequard Syndrome	3.9%
554	Lissencephaly	3.9%
555	Polymicrogyria	3.9%
556	Pachygyria	3.9%
557	Schizencephaly	3.9%
558	Lockjaw	3.9%
559	Allodynia	3.9%
560	Lead Poisoning, Nervous System, Childhood	3.9%
561	Lead Poisoning, Nervous System, Adult	3.9%
562	Periventricular Nodular Heterotopia	3.9%
563	Ageusia	3.9%
564	Tuberculosis, Central Nervous System	3.9%
565	Holoprosencephaly	3.7%
566	Asthenopia	3.7%
567	Conjunctival Diseases	3.7%
568	Corneal Diseases	3.7%
569	Eyelid Diseases	3.7%
570	Lacrimal Apparatus Diseases	3.7%
571	Lens Diseases	3.7%
572	Ocular Hypertension	3.7%
573	Ocular Hypotension	3.7%
574	Retinal Diseases	3.7%
575	Scleral Diseases	3.7%
576	Vitreous Detachment	3.7%
577	Posterior Vitreous Detachment	3.7%
578	Blepharophimosis	3.6%
579	Uveal Neoplasms	3.6%
580	Eyelid Neoplasms	3.6%
581	Retinal Hemorrhage	3.6%
582	Muscular Dystrophy	3.6%
583	Muscle Rigidity	3.6%
584	Muscle Spasticity	3.6%
585	Cogwheel Rigidity	3.6%
586	Hemifacial Spasm	3.6%
587	Nuchal Rigidity	3.6%
588	Reye Syndrome	3.6%
589	Neuroaspergillosis	3.6%
590	Pyomyositis	3.6%
591	Intracranial Embolism and Thrombosis	3.6%
592	Hepatic Encephalopathy	3.6%
593	Agnosia	3.6%
594	Apraxias	3.6%
595	Hallucinations	3.6%
596	Hyperacusis	3.6%
597	Tinnitus	3.6%
598	Visual Agnosia	3.6%
599	Anosognosia	3.6%
600	Wernicke-Korsakoff Syndrome	3.6%
601	Phonophobia	3.6%
602	Hearing Loss	3.6%
603	Sarcopenia	3.5%
604	Immune Complex Diseases	3.5%
605	Latex allergy	3.5%
606	Polyradiculopathy	3.4%
607	Post-Traumatic Headache	3.4%
608	Tension Headache	3.4%
609	Epilepsy, Complex Partial	3.4%
610	Migraine Disorders	3.4%
611	Abdominal Migraine	3.4%
612	Status Migrainosus	3.4%
613	Cervicogenic Headache	3.4%
614	Menkes Kinky Hair Syndrome	3.4%
615	Waterhouse-Friderichsen Syndrome	3.4%
616	Eye Abnormalities	3.4%
617	Eye Infection	3.4%
618	Eye Manifestations	3.4%
619	Eye Neoplasms	3.4%
620	Pseudorabies	3.3%
621	Xerophthalmia	3.3%
622	Iridocorneal endothelial syndrome	3.3%
623	Amnesia	3.3%
624	Delirium	3.3%
625	Dissociative Amnesia	3.3%
626	Global Amnesia	3.3%
627	Cri-du-Chat Syndrome	3.3%
628	Down Syndrome	3.3%
629	Brain Diseases, Metabolic, Inborn	3.3%
630	Trisomy 21	3.3%
631	Meningioma	3.3%
632	Williams Syndrome	3.3%
633	Microcephaly	3.3%
634	Macrocephaly	3.3%
635	Neurosyphilis	3.2%
636	Hypokalemic periodic paralysis	3.2%
637	Porencephaly	3.2%
638	Environmental Illness	3.2%
639	Lymphoproliferative Disorders	3.2%
640	Paraproteinemias	3.1%
641	Lymphopenia	3.1%
642	Empty Sella Syndrome	3.1%
643	Hyperpituitarism	3.1%
644	Hypopituitarism	3.1%
645	Hypophysitis	3.1%
646	Cerebral Arterial Diseases	3.1%
647	Vertebrobasilar Insufficiency	3.1%
648	Anterior Spinal Artery Syndrome	3.1%
649	Basilar Artery Stenosis	3.1%
650	Vertebral Artery Stenosis	3.1%
651	Sleep Apnea, Obstructive	3.1%
652	Sleep Apnea, Central	3.1%
653	Intracranial Hemorrhage, Hypertensive	3.1%
654	Transient Cerebral Ischemia	3.1%
655	Narcolepsy	3.1%
656	Kleine-Levin Syndrome	3.1%
657	Agraphia	3.1%
658	Anomia	3.1%
659	Cluttering	3.1%
660	Language Development Disorders	3.1%
661	Speech Disorders	3.1%
662	Syncope	3.1%
663	Stupor	3.1%
664	Dysgraphia	3.1%
665	Presyncope	3.1%
666	Dyslalia	3.1%
667	Retinoblastoma	3.1%
668	Eye Hemorrhage	3%
669	Prader-Willi Syndrome	3%
670	Wernicke Encephalopathy	3%
671	Primary amyloidosis	3%
672	Corneal Ulcer	3%
673	Phantom pain	3%
674	Phantom Limb Pain	3%
675	Monoclonal Gammopathy of Undetermined Significance	3%
676	Lyme Neuroborreliosis	3%
677	Choroid Hemorrhage	3%
678	Cluster Headache	3%
679	Migraine with Aura	3%
680	Familial Hemiplegic Migraine	3%
681	Chronic Paroxysmal Hemicrania	3%
682	SUNCT Syndrome	3%
683	Paroxysmal Hemicrania	3%
684	Keratoconjunctivitis Sicca	3%
685	Hypergammaglobulinemia	2.9%
686	Agammaglobulinemia	2.8%
687	Kounis Syndrome	2.8%
688	HIV Infections	2.8%
689	Transfusion-Related Acute Lung Injury	2.8%
690	Toxoplasmosis, Congenital	2.8%
691	Eye Burns	2.8%
692	Malaria, Cerebral	2.8%
693	Carotid Stenosis	2.8%
694	Intracranial Aneurysm	2.8%
695	Welander Distal Myopathy	2.8%
696	Neurocysticercosis	2.8%
697	Dyscalculia	2.8%
698	Intracranial Arteriosclerosis	2.8%
699	Cerebral Atherosclerosis	2.8%
700	Rett Syndrome	2.8%
701	Subarachnoid Hemorrhage	2.8%
702	Cerebral Arteriosclerosis	2.8%
703	Cerebral Hemorrhage	2.8%
704	Cerebral Thrombosis	2.8%
705	Intracranial Embolism	2.8%
706	Intracranial Thrombosis	2.8%
707	Deafness	2.8%
708	Hearing Loss, Sudden	2.8%
709	Gerstmann Syndrome	2.8%
710	Hearing Loss, Bilateral	2.8%
711	Hearing Loss, High-Frequency	2.8%
712	Hearing Loss, Mixed Conductive-Sensorineural	2.8%
713	Prosopagnosia	2.8%
714	Apraxia, Ideomotor	2.8%
715	Charles Bonnet Syndrome	2.8%
716	Hearing Loss, Unilateral	2.8%
717	Complete Hearing Loss	2.8%
718	Alien Hand Syndrome	2.8%
719	Deaf Mutism	2.8%
720	Trachoma	2.8%
721	Asthma, Aspirin-Induced	2.8%
722	Fabry Disease	2.7%
723	Hordeolum	2.7%
724	Chorioretinitis	2.7%
725	Retinitis Pigmentosa	2.7%
726	Pigmentary retinopathy	2.7%
727	Hyperprolactinemia	2.7%
728	Subclavian Steal Syndrome	2.7%
729	Pick Disease of the Brain	2.7%
730	Cataplexy	2.7%
731	Aphasia	2.7%
732	Articulation Disorders	2.7%
733	Echolalia	2.7%
734	Stuttering	2.7%
735	Dysphasia	2.7%
736	Keratoconjunctivitis	2.6%
737	Rubinstein-Taybi Syndrome	2.6%
738	Dermatomyositis	2.6%
739	Muscular Dystrophy, Duchenne	2.6%
740	Multiple Myeloma	2.6%
741	Retrograde amnesia	2.6%
742	Amnesia, Anterograde	2.6%
743	Carotid Artery Thrombosis	2.6%
744	Dysarthria	2.5%
745	Mutism	2.4%
746	Selective Mutism	2.4%
747	Acromegaly	2.4%
748	Serum Sickness	2.4%
749	Pars Planitis	2.4%
750	Cerebral Amyloid Angiopathy	2.4%
751	Sinus Thrombosis, Intracranial	2.4%
752	Fragile X Syndrome	2.4%
753	Alexia, Pure	2.2%
754	Cavernous Sinus Thrombosis	2.2%
755	Sagittal Sinus Thrombosis	2.2%
756	Acanthamoeba Keratitis	2.2%
757	Galactosemias	2.2%
758	Urea Cycle Disorders, Inborn	2.2%
759	Tyrosinemias	2.2%
760	Keratitis, Herpetic	2.2%
761	Cytomegalovirus Retinitis	2.2%
762	Angioid Streaks	2.2%
763	Anisometropia	2.2%
764	Aphakia	2.2%
765	Astigmatism	2.2%
766	Blepharitis	2.2%
767	Blepharoptosis	2.2%
768	Blepharospasm	2.2%
769	Choroid Diseases	2.2%
770	Conjunctivitis	2.2%
771	Corneal edema	2.2%
772	Corneal Opacity	2.2%
773	Dacryocystitis	2.2%
774	Dry Eye Syndromes	2.2%
775	Ectropion	2.2%
776	Enophthalmos	2.2%
777	Entropion	2.2%
778	Episcleritis	2.2%
779	Exophthalmos	2.2%
780	Glaucoma	2.2%
781	Iris Diseases	2.2%
782	Keratitis	2.2%
783	Keratoconus	2.2%
784	Lacrimal Duct Obstruction	2.2%
785	Lens dislocation	2.2%
786	Lens Subluxation	2.2%
787	Mydriasis	2.2%
788	Myopia	2.2%
789	Presbyopia	2.2%
790	Pterygium	2.2%
791	Retinal Detachment	2.2%
792	Retinitis	2.2%
793	Scleritis	2.2%
794	Uveitis	2.2%
795	Corneal Neovascularization	2.2%
796	Orbital Pseudotumor	2.2%
797	Cataract	2.2%
798	Pinguecula	2.2%
799	Trichiasis	2.2%
800	Bacterial conjunctivitis	2.2%
801	Choroiditis	2.1%
802	Iridocyclitis	2.1%
803	Iritis	2.1%
804	Hydrops Fetalis	2.1%
805	Prolactinoma	2.1%
806	Growth Hormone-Secreting Pituitary Adenoma	2.1%
807	Homocystinuria	2.1%
808	Nelson Syndrome	2.1%
809	Leigh Disease	2.1%
810	anaphylaxis	2%
811	Food Allergy	2%
812	Anaphylactic shock	2%
813	Anophthalmos	2%
814	Endophthalmitis	2%
815	Microphthalmos	2%
816	Pemphigoid, Benign Mucous Membrane	2%
817	Retinal Artery Occlusion	2%
818	Retinopathy of Prematurity	2%
819	Orbital Cellulitis	2%
820	Retinal Vasculitis	2%
821	Hypertensive Retinopathy	2%
822	Retrobulbar Hemorrhage	2%
823	Corneal Endothelial Cell Loss	2%
824	Hyphema	2%
825	Retinal Neovascularization	2%
826	Vitreous Hemorrhage	2%
827	Panophthalmitis	1.9%
828	Mucopolysaccharidosis II	1.9%
829	Respiratory Hypersensitivity	1.8%
830	Sick Building Syndrome	1.8%
831	Multiple Chemical Sensitivity	1.8%
832	Sezary Syndrome	1.8%
833	Retinal Vein Occlusion	1.8%
834	Plasmacytoma	1.8%
835	Tumor Lysis Syndrome	1.8%
836	Urticaria	1.8%
837	Vasculitis, Leukocytoclastic, Cutaneous	1.8%
838	HTLV-I Infections	1.8%
839	Job Syndrome	1.8%
840	Diabetic Retinopathy	1.8%
841	Eye pain	1.8%
842	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.8%
843	Zellweger Syndrome	1.7%
844	Glycogen storage disease type II	1.7%
845	Lymphoma	1.6%
846	Mastocytosis	1.6%
847	Drug Eruptions	1.6%
848	Chronic granulomatous disease	1.6%
849	Heavy Chain Disease	1.6%
850	Dermatitis, Allergic Contact	1.6%
851	HIV Seropositivity	1.6%
852	Acquired Immunodeficiency Syndrome	1.5%
853	AIDS related complex	1.5%
854	Infectious Mononucleosis	1.5%
855	Cryoglobulinemia	1.5%
856	Angle Closure Glaucoma	1.5%
857	Glaucoma, Open-Angle	1.5%
858	Macular degeneration	1.5%
859	Panuveitis	1.5%
860	Retinal Drusen	1.5%
861	Retinal Necrosis Syndrome, Acute	1.5%
862	Retinoschisis	1.5%
863	Exfoliation Syndrome	1.5%
864	Gaucher Disease	1.4%
865	AIDS-Related Opportunistic Infections	1.4%
866	Ophthalmia Neonatorum	1.4%
867	Dermatitis, Atopic	1.4%
868	HIV Wasting Syndrome	1.4%
869	AIDS-Associated Nephropathy	1.4%
870	Tay-Sachs Disease	1.3%
871	Albinism	1.3%
872	Choroidal Neovascularization	1.3%
873	Niemann-Pick Disease, Type C	1.3%
874	Waldenstrom Macroglobulinemia	1.3%
875	Wiskott-Aldrich Syndrome	1.3%
876	HIV-Associated Lipodystrophy Syndrome	1.3%
877	Milk Allergy	1.3%
878	Schnitzler Syndrome	1.3%
879	Wheat Hypersensitivity	1.3%
880	CHARGE Syndrome	1.2%
881	Herpes Zoster Ophthalmicus	1.2%
882	Mastocytosis, Systemic	1.1%
883	Anterior uveitis	1.1%
884	Uveitis, Posterior	1.1%
885	Mandibulofacial Dysostosis	1.1%
886	Angioedema	1%
887	Hodgkin Disease	1%
888	Leukemia, Plasma Cell	1%
889	Lymphoma, Non-Hodgkin	1%
890	Leukemia, T-Cell	1%
891	Acute Generalized Exanthematous Pustulosis	1%
892	Leukemia, B-Cell	1%
893	Asthma	1%
894	Composite Lymphoma	1%
895	Erythema Nodosum	0.9%
896	Dermatitis, Photoallergic	0.9%
897	Lymphangioleiomyomatosis	0.9%
898	Aspergillosis, Allergic Bronchopulmonary	0.9%
899	Toxic Epidermal Necrolysis	0.8%
900	Stevens-Johnson Syndrome	0.8%
901	Asthma, Exercise-Induced	0.7%
902	Status Asthmaticus	0.7%
903	Lymphoma, Follicular	0.7%
904	T-Cell Lymphoma	0.7%
905	Mantle cell lymphoma	0.7%
906	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	0.7%
907	Leukemia, Large Granular Lymphocytic	0.7%
908	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	0.7%
909	Asthma, Occupational	0.7%
910	Farmer's Lung	0.7%
911	Angioedemas, Hereditary	0.7%
912	Hay fever	0.7%
913	Rhinitis, Allergic, Perennial	0.7%
914	Hereditary Angioedema Type III	0.6%
915	Hereditary Angioedema Types I and II	0.6%
916	Lymphoma, T-Cell, Cutaneous	0.6%
917	Lymphoma, AIDS-Related	0.6%
918	Enteropathy-Associated T-Cell Lymphoma	0.6%
919	Primary Effusion Lymphoma	0.6%
920	Behcet Syndrome	0.6%
921	Lymphomatoid Granulomatosis	0.5%
922	Mycosis Fungoides	0.5%
923	Lymphomatoid Papulosis	0.5%
924	Plasmablastic lymphoma	0.5%
925	Burkitt Lymphoma	0.5%

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