MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Sickle Cell Trait

(UMLS:C0037054)

Definition:: The condition of being heterozygous for hemoglobin S.
UMLS ID:: C0037054
MeSH ID:: D012805

Classification 1:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.071.141.150.150.670|C15.378.420.155.668

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.070.150.670|C16.320.365.155.668

Synonym(s)

Sickle Cell Trait

AS - Sickle cell trait

AS genotype; hemoglobin

Drepanocytosis

Haemoglobin A-S genotype

Haemoglobin S trait

Haemoglobin S-A disorder

Hb-S; trait

Hemoglobin A-S genotype

10.

Hemoglobin S trait

11.

Hemoglobin S-A disease

12.

Hemoglobin S-A disorder

13.

Heterozygous for Hb S

14.

Heterozygous haemoglobin S

15.

Heterozygous hemoglobin S

16.

RBC's - sickle cells present

17.

S; hemoglobin

18.

SICKLE CELL TRAIT

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Paroxetine	FAERS: 6	US FAERS
2	Lenalidomide	FAERS: 5	US FAERS
3	Alendronate	FAERS: 4	US FAERS
4	Ranitidine	FAERS: 3	US FAERS
5	rofecoxib	FAERS: 3	US FAERS
6	Desogestrel	FAERS: 2	US FAERS
7	Citalopram	FAERS: 1	US FAERS
8	Clozapine	FAERS: 1	US FAERS
9	Deferoxamine	FAERS: 1	US FAERS
10	NuvaRing	FAERS: 1	US FAERS
11	Ondansetron	FAERS: 1	US FAERS
12	Quetiapine Fumarate	FAERS: 1	US FAERS
13	Ranitidine	FAERS: 1	US FAERS
14	Zoledronic Acid	FAERS: 1	US FAERS
15	ambrisentan	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Thalassemia	46.9%
2	Acute Chest Syndrome	46.2%
3	Pelger-Huet Anomaly	25%
4	Thrombasthenia	24.1%
5	Antithrombin III Deficiency	24.1%
6	Protein C Deficiency	24.1%
7	Wiskott-Aldrich Syndrome	22.2%
8	Disseminated Intravascular Coagulation	22%
9	Protein S Deficiency	22%
10	Afibrinogenemia	21.6%
11	Factor VII Deficiency	21.6%
12	Factor X Deficiency	21.6%
13	Factor XII Deficiency	21.6%
14	Hemophilia A	21.6%
15	Activated Protein C Resistance	21.6%
16	Factor II deficiency	21.6%
17	Factor VIII Deficiency	21.6%
18	Factor V deficiency	21.6%
19	Factor XI Deficiency	21.6%
20	Hypoprothrombinemias	21.6%
21	Anemia, Diamond-Blackfan	19.8%
22	Thrombocythemia, Essential	19.4%
23	Anemia, Neonatal	19%
24	Hemoglobinuria, Paroxysmal	18.5%
25	Blood Coagulation Disorders	18.2%
26	Blood Platelet Disorders	18.2%
27	Bone Marrow Diseases	18.2%
28	Hemorrhagic Disorders	18.2%
29	Leukocyte Disorders	18.2%
30	Methemoglobinemia	18.2%
31	Pancytopenia	18.2%
32	Polycythemia	18.2%
33	Sulfhemoglobinemia	18.2%
34	Thrombophilia	18.2%
35	Erythrocytosis	18.2%
36	Neoplastic Syndromes, Hereditary	17%
37	CHARGE Syndrome	16.9%
38	Cystic Fibrosis	16.9%
39	Aicardi's syndrome	16.6%
40	Multiple Epiphyseal Dysplasia	16.4%
41	Osteochondrodysplasias	16.4%
42	Werner Syndrome	16.4%
43	Myasthenic Syndromes, Congenital	16.4%
44	Anemia, Macrocytic	16%
45	Transfusion Reaction	15.7%
46	Hypotensive Transfusion Reaction	15.7%
47	Pregnancy Complications, Hematologic	15.4%
48	Hematologic Neoplasms	15.4%
49	Nail-Patella Syndrome	15%
50	Hydrops Fetalis	14.7%
51	Bone Marrow Neoplasms	14.7%
52	Autoimmune Lymphoproliferative Syndrome	14.6%
53	Vitamin K Deficiency	14.6%
54	Muscular Dystrophy, Duchenne	14.6%
55	Dwarfism	14.5%
56	Ichthyosis, X-Linked	14.5%
57	Albinism	14.3%
58	Fragile X Syndrome	14.3%
59	Muscular Dystrophy	14%
60	Osteogenesis Imperfecta	14%
61	Beckwith-Wiedemann Syndrome	14%
62	Wolf-Hirschhorn Syndrome	14%
63	Fanconi Anemia	13.9%
64	Cockayne Syndrome	13.7%
65	Thrombocytosis	13.7%
66	Chronic granulomatous disease	12.9%
67	Hemolytic-Uremic Syndrome	12.6%
68	Alstrom Syndrome	12.5%
69	Smith-Magenis syndrome	12.4%
70	Cri-du-Chat Syndrome	12.2%
71	Down Syndrome	12.2%
72	Angioedemas, Hereditary	12.2%
73	Trisomy 21	12.2%
74	Deformity	12.1%
75	Marfan Syndrome	12.1%
76	Kartagener Syndrome	12%
77	Anemia, Sickle Cell	11.9%
78	Polycythemia Vera	11.8%
79	Familial Mediterranean Fever	11.6%
80	Lymphatic Diseases	11.6%
81	Holoprosencephaly	11.3%
82	Mucopolysaccharidosis II	11.2%
83	Menkes Kinky Hair Syndrome	11%
84	Rett Syndrome	11%
85	Ectodermal Dysplasia	10.9%
86	Aplasia Cutis Congenita	10.9%
87	Prader-Willi Syndrome	10.8%
88	Kallmann Syndrome	10.7%
89	Lymphatic Abnormalities	10.7%
90	Myotonic Dystrophy	10.6%
91	Leukemoid Reaction	10.4%
92	Fetal Diseases	10.2%
93	Eosinophilia	10.2%
94	Hypoproteinemia	10.2%
95	Leukopenia	10.2%
96	Thrombocytopenia	10.2%
97	Leukostasis	10.2%
98	MYELODYSPLASTIC SYNDROME	10.2%
99	Pseudoxanthoma Elasticum	10.1%
100	Rubinstein-Taybi Syndrome	10.1%
101	Tuberous Sclerosis	10%
102	Purpura, Thrombotic Thrombocytopenic	9.9%
103	Agammaglobulinemia	9.9%
104	Anemia	9.8%
105	Amino Acid Metabolism, Inborn Errors	9.7%
106	Carbohydrate Metabolism, Inborn Errors	9.7%
107	Metal Metabolism, Inborn Errors	9.7%
108	Progeria	9.7%
109	Lysosomal Storage Diseases	9.7%
110	Cytochrome-c Oxidase Deficiency	9.7%
111	Peroxisomal Disorders	9.7%
112	Polycystic Kidney Diseases	9.7%
113	Williams Syndrome	9.7%
114	Neuronal Ceroid-Lipofuscinoses	9.7%
115	Smith-Lemli-Opitz Syndrome	9.7%
116	Anemia, Megaloblastic	9.5%
117	Primary Ciliary Dyskinesia	9.4%
118	Sjogren-Larsson Syndrome	9.2%
119	Adrenoleukodystrophy	9.2%
120	Hepatolenticular Degeneration	9.1%
121	Ataxia Telangiectasia	9%
122	Retinal Dysplasia	8.9%
123	Aniridia	8.9%
124	Amyloid Neuropathies, Familial	8.8%
125	Epidermolysis Bullosa	8.7%
126	Leukocytosis	8.6%
127	Paraproteinemias	8.6%
128	Pleocytosis	8.6%
129	Refsum Disease	8.6%
130	Infectious Mononucleosis	8.5%
131	Cutis Laxa	8.5%
132	Retinitis Pigmentosa	8.4%
133	Pigmentary retinopathy	8.4%
134	Porokeratosis	8.4%
135	Keratoderma, Palmoplantar	8.4%
136	Atypical Hemolytic Uremic Syndrome	8.4%
137	Welander Distal Myopathy	8.3%
138	Autoimmune thrombocytopenia	8.2%
139	Immune thrombocytopenic purpura	8.2%
140	Waldenstrom Macroglobulinemia	8.1%
141	Fabry Disease	8.1%
142	Cryoglobulinemia	7.9%
143	Monoclonal Gammopathy of Undetermined Significance	7.9%
144	Sickle Cell Trait	7.8%
145	Galactosemias	7.7%
146	Urea Cycle Disorders, Inborn	7.7%
147	Tyrosinemias	7.7%
148	Lymphangiectasis, Intestinal	7.7%
149	Duane Retraction Syndrome	7.5%
150	Hypergammaglobulinemia	7.5%
151	Meconium Aspiration Syndrome	7.4%
152	Porphyrias, Hepatic	7.4%
153	Transfusion-Related Acute Lung Injury	7.4%
154	Ecchymosis	7.3%
155	Petechiae	7.3%
156	Purpura	7.3%
157	Peutz-Jeghers Syndrome	7.3%
158	Myotonia Congenita	7.3%
159	Brain Diseases, Metabolic, Inborn	7.3%
160	Dystonia Musculorum Deformans	7.3%
161	Canavan Disease	7.2%
162	Alexander Disease	7.2%
163	Lafora Disease	7.2%
164	Unverricht-Lundborg Syndrome	7.2%
165	Glycogen storage disease type II	7.2%
166	Kernicterus	7.2%
167	Optic Atrophy, Hereditary, Leber	7.1%
168	Hyperphosphaturia	7%
169	Purpura, Hyperglobulinemic	7%
170	Zellweger Syndrome	7%
171	Heavy Chain Disease	7%
172	Multiple Endocrine Neoplasia	6.7%
173	Xeroderma Pigmentosum	6.6%
174	Xeroderma	6.6%
175	Mobius Syndrome	6.6%
176	Congenital Hypothyroidism	6.6%
177	Dermatitis, Atopic	6.6%
178	Abdominal Cramps	6.5%
179	Abnormalities, Drug-Induced	6.5%
180	Amniotic Band Syndrome	6.5%
181	Asphyxia Neonatorum	6.5%
182	Infant, Premature, Diseases	6.5%
183	Situs Inversus	6.5%
184	Infantile Colic	6.5%
185	Alkaptonuria	6.4%
186	Glycogen Storage Disease	6.4%
187	Hypophosphatasia	6.4%
188	Propionic acidemia	6.4%
189	Dihydropyrimidine Dehydrogenase Deficiency	6.4%
190	Cystinosis	6.4%
191	Polycystic Kidney, Autosomal Dominant	6.4%
192	Mucopolysaccharidosis III	6.4%
193	POEMS Syndrome	6.4%
194	Multiple Myeloma	6.4%
195	Waterhouse-Friderichsen Syndrome	6.3%
196	Primary Myelofibrosis	6.3%
197	Agranulocytosis	6.3%
198	Lymphocytosis	6.3%
199	Myelofibrosis	6.3%
200	Myeloid Metaplasia	6.3%
201	Hypoalbuminemia	6.3%
202	Hypereosinophilic syndrome	6.3%
203	bone marrow fibrosis	6.3%
204	Thrombotic Microangiopathies	6.3%
205	Classical Lissencephalies and Subcortical Band Heterotopias	6.2%
206	Homocystinuria	6.2%
207	Leigh Disease	6.1%
208	Hyperkeratosis, Epidermolytic	6.1%
209	Adenitis	6.1%
210	Histiocytosis	6.1%
211	Lymphadenitis	6.1%
212	Lymphangitis	6.1%
213	Lymphedema	6.1%
214	Splenic Diseases	6.1%
215	Thymus Hyperplasia	6.1%
216	Pseudolymphoma	6.1%
217	Lymphadenopathy	6.1%
218	Thrombocytopenic purpura	6%
219	Basal Cell Nevus Syndrome	6%
220	Behcet Syndrome	5.9%
221	Anemia, Hemolytic	5.8%
222	Charcot-Marie-Tooth Disease	5.7%
223	Antley-Bixler Syndrome Phenotype	5.7%
224	Eye Abnormalities	5.7%
225	Cardiovascular Abnormalities	5.7%
226	Skin Abnormalities	5.5%
227	Congenital Microtia	5.5%
228	Hypolipoproteinemias	5.5%
229	Papillon-Lefevre Disease	5.5%
230	Hyperlipidemia, Familial Combined	5.5%
231	Hyperlipoproteinemia Type III	5.5%
232	Gaucher Disease	5.5%
233	Persistent Fetal Circulation Syndrome	5.5%
234	Congenital diaphragmatic hernia	5.4%
235	Umbilical hernia	5.4%
236	Huntington Disease	5.3%
237	Lymphopenia	5.3%
238	Job Syndrome	5.2%
239	Carbamoyl-Phosphate Synthase I Deficiency Disease	5.2%
240	Leukemia, Myelomonocytic, Chronic	5.2%
241	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	5.2%
242	Anemia, Pernicious	5.2%
243	Lymphocele	5.1%
244	Lymphoproliferative Disorders	5.1%
245	Niemann-Pick Disease, Type C	5.1%
246	Thymus Neoplasms	5.1%
247	Familial Periodic Paralysis	4.9%
248	Urogenital Abnormalities	4.9%
249	Nephroblastoma	4.9%
250	Lactose Intolerance	4.8%
251	Variegate Porphyria	4.8%
252	Acute intermittent porphyria	4.8%
253	Porphyria Cutanea Tarda	4.8%
254	Hyperhomocysteinemia	4.8%
255	Renal Aminoacidurias	4.8%
256	Fanconi Syndrome	4.8%
257	Pseudohypoaldosteronism	4.8%
258	Liddle Syndrome	4.8%
259	Hyperlipoproteinemia Type IV	4.8%
260	Hyperlipoproteinemia Type V	4.8%
261	Glycogen Storage Disease Type I	4.8%
262	Glycogen Storage Disease Type V	4.8%
263	Neonatal Abstinence Syndrome	4.8%
264	Eosinophilic Granuloma	4.7%
265	Fetal Growth Retardation	4.7%
266	Fetal Hypoxia	4.7%
267	Congenital nystagmus	4.7%
268	Fetal Alcohol Spectrum Disorders	4.7%
269	Toxoplasmosis, Congenital	4.6%
270	Tay-Sachs Disease	4.6%
271	Anencephaly	4.6%
272	Syphilis, Congenital	4.6%
273	Eosinophilia-Myalgia Syndrome	4.6%
274	Shwartzman Phenomenon	4.5%
275	Hemangioma, Cavernous	4.5%
276	Scurvy	4.5%
277	Purpura Fulminans	4.5%
278	Adenomatous Polyposis Coli	4.5%
279	Klinefelter Syndrome	4.4%
280	Gout	4.4%
281	Mucocutaneous Lymph Node Syndrome	4.3%
282	Multiple Endocrine Neoplasia Type 1	4.3%
283	Pseudohypoparathyroidism	4.3%
284	Neutropenia	4.3%
285	Friedreich Ataxia	4.3%
286	Renal tubular acidosis	4.3%
287	Turner Syndrome	4.2%
288	Congenital Hyperinsulinism	4.1%
289	Hypoalphalipoproteinemias	4.1%
290	Chorioamnionitis	4.1%
291	Maxillofacial Abnormalities	4.1%
292	Dural Arteriovenous Fistula	4.1%
293	Dextrocardia	4.1%
294	Prune Belly Syndrome	3.9%
295	Twins, Conjoined	3.9%
296	Waardenburg Syndrome	3.9%
297	Pulmonary Eosinophilia	3.7%
298	Eosinophilic Pneumonia	3.7%
299	Abnormalities, Radiation-Induced	3.6%
300	Hypokalemic periodic paralysis	3.6%
301	Leukemia, Myeloid, Chronic-Phase	3.6%
302	Cystinuria	3.6%
303	Familial Hypophosphatemic Rickets	3.6%
304	Glycosuria, Renal	3.5%
305	Elephantiasis	3.4%
306	Hypersplenism	3.4%
307	Sarcoidosis	3.4%
308	Elephantiasis Nostras Verrucosa	3.4%
309	Febrile Neutropenia	3.4%
310	Scimitar Syndrome	3.3%
311	Anophthalmos	3.3%
312	Anus, Imperforate	3.3%
313	Hydranencephaly	3.3%
314	Microphthalmos	3.3%
315	Neural Tube Defects	3.3%
316	Paralysis, Obstetric	3.3%
317	Retinopathy of Prematurity	3.3%
318	Tethered Cord Syndrome	3.3%
319	Iniencephaly	3.3%
320	Craniorachischisis	3.3%
321	Limb Deformities, Congenital	3.3%
322	Exencephaly	3.3%
323	Septo-Optic Dysplasia	3.3%
324	Craniofacial Abnormalities	3.3%
325	Cortical Dysplasia	3.3%
326	Malformations of Cortical Development	3.3%
327	Anorectal Malformations	3.3%
328	Bloom Syndrome	3.2%
329	Ophthalmia Neonatorum	3.2%
330	Bronchopulmonary Dysplasia	3.2%
331	Arthritis, Gouty	3.2%
332	Denys-Drash Syndrome	3%
333	MELAS Syndrome	3%
334	Craniosynostosis	2.9%
335	Syndactyly	2.9%
336	Brachycephaly	2.9%
337	Granuloma	2.9%
338	Histiocytic Disorders, Malignant	2.9%
339	Splenic Infarction	2.9%
340	Splenic Neoplasms	2.9%
341	Blepharophimosis	2.8%
342	Laryngostenosis	2.8%
343	Mouth Abnormalities	2.8%
344	Respiratory Distress Syndrome, Newborn	2.8%
345	Histiocytosis, Langerhans-Cell	2.8%
346	Tumor Lysis Syndrome	2.8%
347	Esophageal Atresia	2.8%
348	Intestinal Atresia	2.8%
349	Horseshoe Kidney	2.8%
350	Pectus excavatum	2.8%
351	Microcephaly	2.8%
352	Macrocephaly	2.8%
353	Klippel-Feil Syndrome	2.8%
354	Gastroschisis	2.8%
355	Synostosis	2.8%
356	Acrodermatitis	2.8%
357	Gianotti-Crosti Syndrome	2.8%
358	Acrocephalosyndactylia	2.7%
359	Noonan Syndrome	2.6%
360	Arthrogryposis	2.5%
361	Choanal Atresia	2.5%
362	Tracheobronchomegaly	2.5%
363	Laryngocele	2.5%
364	Choledochal Cyst	2.5%
365	Hermaphroditism	2.5%
366	Disorders of Sex Development	2.5%
367	Splenic Rupture	2.5%
368	Cryptorchidism	2.5%
369	Hypospadias	2.5%
370	Lymphoma	2.5%
371	Central Nervous System Cysts	2.5%
372	Dandy-Walker Syndrome	2.5%
373	Thymoma	2.4%
374	Leukomalacia, Periventricular	2.4%
375	Nesidioblastosis	2.4%
376	Sezary Syndrome	2.4%
377	Porencephaly	2.4%
378	Cleft Palate	2.4%
379	Jaw Abnormalities	2.3%
380	Laryngomalacia	2.2%
381	Pectus carinatum	2.2%
382	Bladder Exstrophy	2.2%
383	Epispadias	2.2%
384	Multicystic Dysplastic Kidney	2.2%
385	Amelia	2.2%
386	Arachnodactyly	2.2%
387	Ectopia Cordis	2.2%
388	Ectromelia	2.2%
389	Hemimelia	2.2%
390	Meningomyelocele	2.2%
391	Phocomelia	2.2%
392	Sirenomelia	2.2%
393	Spina Bifida	2.2%
394	Polydactyly	2.2%
395	Brachydactyly	2.2%
396	Plagiocephaly	2.2%
397	Lower Extremity Deformities, Congenital	2.2%
398	Upper Extremity Deformities, Congenital	2.2%
399	Single umbilical artery	2.2%
400	Poland Syndrome	2.1%
401	Lymphohistiocytosis, Hemophagocytic	2.1%
402	Erdheim-Chester Disease	2.1%
403	Aortic coarctation	1.9%
404	Cor Triatriatum	1.9%
405	Coronary Vessel Anomalies	1.9%
406	Dental Enamel Hypoplasia	1.9%
407	Patent ductus arteriosus	1.9%
408	Ebstein Anomaly	1.9%
409	Heart Septal Defects	1.9%
410	Hyaline Membrane Disease	1.9%
411	Hypodontia	1.9%
412	Macrostomia	1.9%
413	Meningocele	1.9%
414	Microstomia	1.9%
415	Tetralogy of Fallot	1.9%
416	Transposition of Great Vessels	1.9%
417	Hypoplastic Left Heart Syndrome	1.9%
418	May-Thurner Syndrome	1.9%
419	Encephalocele	1.9%
420	Craniofacial Dysostosis	1.8%
421	Wolff-Parkinson-White Syndrome	1.8%
422	Micrognathism	1.8%
423	Pierre Robin Syndrome	1.8%
424	Malignant histiocytosis	1.7%
425	Sarcoidosis, Pulmonary	1.7%
426	Histiocytic sarcoma	1.7%
427	Long QT Syndrome	1.6%
428	Platybasia	1.6%
429	Tricuspid Atresia	1.6%
430	Arrhythmogenic Right Ventricular Dysplasia	1.6%
431	Gonadal Dysgenesis	1.6%
432	Bronchomalacia	1.6%
433	Adrenogenital Syndrome	1.6%
434	Tracheomalacia	1.6%
435	Ovotesticular Disorders of Sex Development	1.6%
436	Retrognathia	1.6%
437	Dermal Sinus	1.6%
438	Spina Bifida Cystica	1.6%
439	Spina Bifida Occulta	1.6%
440	Lissencephaly	1.6%
441	Polymicrogyria	1.6%
442	Pachygyria	1.6%
443	Schizencephaly	1.6%
444	Periventricular Nodular Heterotopia	1.6%
445	Hyperandrogenism	1.6%
446	Splenosis	1.5%
447	Hodgkin Disease	1.5%
448	Lymphoma, Non-Hodgkin	1.5%
449	Leukemia, T-Cell	1.5%
450	Leukemia, B-Cell	1.5%
451	Prognathism	1.5%
452	Aortopulmonary Septal Defect	1.4%
453	Double Outlet Right Ventricle	1.4%
454	Endocardial Cushion Defects	1.4%
455	Myocardial bridging	1.4%
456	Aorticopulmonary Septal Defect	1.4%
457	Composite Lymphoma	1.3%
458	Lymphangioleiomyomatosis	1.3%
459	Mandibulofacial Dysostosis	1.2%
460	Romano-Ward Syndrome	1.2%
461	Truncus Arteriosus, Persistent	1.1%
462	Goldenhar Syndrome	1.1%
463	Lymphoma, Follicular	1%
464	T-Cell Lymphoma	1%
465	Mantle cell lymphoma	1%
466	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1%
467	Leukemia, Large Granular Lymphocytic	1%
468	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1%
469	Talipes	1%
470	Arteriovenous fistula	1%
471	Congenital clubfoot	0.9%
472	Vertical Talus	0.9%
473	Lymphoma, T-Cell, Cutaneous	0.8%
474	Lymphoma, AIDS-Related	0.8%
475	Enteropathy-Associated T-Cell Lymphoma	0.8%
476	Primary Effusion Lymphoma	0.8%
477	Lymphomatoid Granulomatosis	0.7%
478	Mycosis Fungoides	0.7%
479	Lymphomatoid Papulosis	0.7%
480	Plasmablastic lymphoma	0.7%
481	Burkitt Lymphoma	0.6%

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