MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Bone Demineralization, Pathologic

(UMLS:C0242699)

Definition:: Decrease, loss, or removal of the mineral constituents of bones. Temporary loss of bone mineral content is especially associated with space flight, weightlessness, and extended immobilization. OSTEOPOROSIS is permanent, includes reduction of total bone mass, and is associated with increased rate of fractures. CALCIFICATION, PHYSIOLOGIC is the process of bone remineralizing. (From Dorland, 27th ed; Stedman, 25th ed; Nicogossian, Space Physiology and Medicine, 2d ed, pp327-33)
UMLS ID:: C0242699
MeSH ID:: D018488

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.198.247

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.104.247

Synonym(s)

Bone Demineralization, Pathologic

bone demineralization

bones demineralization

demineralization of bone

demineralization; bone

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Beclomethasone	9232087	CTD
2	Cadmium Compounds	23954550	CTD
3	Caffeine	19325779	CTD
4	Furosemide	3084585	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Osteoporosis	46.7%
2	Post-Traumatic Osteoporosis	46.7%
3	Rickets	38.7%
4	Pseudohypoparathyroidism	36.3%
5	Osteoporosis, Postmenopausal	34.4%
6	Osteomalacia	28.7%
7	Osteoarthropathy, Secondary Hypertrophic	20.7%
8	Wasting Syndrome	20.7%
9	Acid-Base Imbalance	20.5%
10	Bone Diseases, Developmental	20.5%
11	Calcium Metabolism Disorders	20.5%
12	Iron Metabolism Disorders	20.5%
13	Hyperostosis	20.5%
14	Osteitis	20.5%
15	Osteitis Deformans	20.5%
16	Osteochondrosis	20.5%
17	Phosphorus Metabolism Disorders	20.5%
18	Spinal Diseases	20.5%
19	Water-Electrolyte Imbalance	20.5%
20	Lipid Metabolism Disorders	20.5%
21	Mitochondrial Diseases	20.5%
22	Glucose Metabolism Disorders	20.5%
23	Hypercalcemia	20%
24	Hypocalcemia	20%
25	Milk-Alkali Syndrome	20%
26	Renal Osteodystrophy	19.2%
27	Renal rickets	19.2%
28	Familial Hypophosphatemic Rickets	17%
29	Osteochondritis	16.4%
30	Bone Diseases, Endocrine	16.1%
31	Gigantism	16%
32	Lipodystrophy	16%
33	Spinal Neoplasms	16%
34	Spondylitis	16%
35	Bone Diseases, Infectious	15.5%
36	Bone neoplasms	15.5%
37	Platybasia	15.5%
38	Bone Resorption	15.3%
39	Brain Diseases, Metabolic	15.3%
40	Aseptic Necrosis of Bone	15.3%
41	Leigh Disease	13.5%
42	Acidosis	13.3%
43	Ainhum	13.3%
44	Alkalosis	13.3%
45	Amyloidosis	13.3%
46	Calcinosis	13.3%
47	Dysostoses	13.3%
48	Hyperglycemia	13.3%
49	Hyperinsulinism	13.3%
50	Hyperkalemia	13.3%
51	Hypernatremia	13.3%
52	Hypoglycemia	13.3%
53	Hypokalemia	13.3%
54	Hyponatremia	13.3%
55	Spinal Stenosis	13.3%
56	Spondylosis	13.3%
57	Xanthomatosis	13.3%
58	Hypophosphatemia	13.3%
59	Intervertebral Disc Degeneration	13.3%
60	Metabolic acidosis	13.3%
61	Dyslipidemias	13.3%
62	Iron Overload	13.3%
63	Xanthoma	13.3%
64	Brain Diseases, Metabolic, Inborn	13.3%
65	Hyperhomocysteinemia	12.7%
66	Carbamoyl-Phosphate Synthase I Deficiency Disease	12.4%
67	Mitochondrial Myopathies	12.2%
68	Pectus excavatum	12.2%
69	Hyperlipoproteinemia Type IV	12.1%
70	Hyperlipoproteinemia Type V	12.1%
71	Fasciitis	11.9%
72	Foot Deformities	11.9%
73	Arthropathy	11.9%
74	Nutrition Disorders	11.9%
75	Discitis	11.8%
76	Hypolipoproteinemias	11.8%
77	Mitochondrial Encephalomyopathies	11.7%
78	Pectus carinatum	11.7%
79	Lactose Intolerance	11.5%
80	Smith-Lemli-Opitz Syndrome	11%
81	Galactosemias	11%
82	Urea Cycle Disorders, Inborn	11%
83	Tyrosinemias	11%
84	Gout	11%
85	Diabetic Ketoacidosis	10.8%
86	Hyperlipidemia, Familial Combined	10.7%
87	Diabetes Mellitus	10.5%
88	Arthrogryposis	10.3%
89	Contracture	10.3%
90	Fasciitis, Plantar	10.3%
91	Hyperlipoproteinemia Type III	10.2%
92	Dehydration	10.2%
93	Lipomatosis	10.2%
94	Multiple Epiphyseal Dysplasia	10.2%
95	Osteochondrodysplasias	10.2%
96	Water Intoxication	10.2%
97	Werner Syndrome	10.2%
98	Congenital Hyperinsulinism	10.1%
99	Klippel-Feil Syndrome	10.1%
100	Synostosis	10.1%
101	Congenital Hypothyroidism	10%
102	Achlorhydria	10%
103	Amino Acid Metabolism, Inborn Errors	10%
104	Bloom Syndrome	10%
105	Carbohydrate Metabolism, Inborn Errors	10%
106	Metal Metabolism, Inborn Errors	10%
107	Osteomyelitis	10%
108	Periostitis	10%
109	Progeria	10%
110	Lysosomal Storage Diseases	10%
111	Cytochrome-c Oxidase Deficiency	10%
112	Peroxisomal Disorders	10%
113	Gaucher Disease	10%
114	Alveolar Bone Loss	9.9%
115	Celiac Disease	9.9%
116	Femur Head Necrosis	9.9%
117	Sprue, Tropical	9.9%
118	Steatorrhea	9.9%
119	Sprue	9.9%
120	Osteolysis	9.9%
121	Acidosis, Lactic	9.9%
122	Calciphylaxis	9.9%
123	Chondrodysplasia Punctata	9.9%
124	Enchondromatosis	9.9%
125	Hemosiderosis	9.9%
126	Ketosis	9.9%
127	Lordosis	9.9%
128	Osteosclerosis	9.9%
129	Spondylolysis	9.9%
130	Ketonuria	9.9%
131	Ketoacidosis	9.9%
132	Ketonemia	9.9%
133	Vascular calcification	9.9%
134	kyphosis	9.9%
135	Kashin-Beck Disease	9.9%
136	Tuberculosis, Spinal	9.7%
137	Hyperphosphaturia	9.7%
138	Hypoalphalipoproteinemias	9.7%
139	Glycogen storage disease type II	9.6%
140	Antley-Bixler Syndrome Phenotype	9.6%
141	Osteoarthritis, Spine	9.5%
142	Jaw Diseases	9.3%
143	Homocystinuria	9.3%
144	Tay-Sachs Disease	9%
145	Cartilage Diseases	8.9%
146	Foot Diseases	8.9%
147	Myopathy	8.9%
148	Rheumatism	8.9%
149	Chondromalacia	8.9%
150	Cockayne Syndrome	8.7%
151	Amyloid Neuropathies, Familial	8.7%
152	Ankylosing spondylitis	8.6%
153	Spondylarthropathies	8.6%
154	Craniofacial Dysostosis	8.6%
155	Eosinophilic Granuloma	8.5%
156	Niemann-Pick Disease, Type C	8.5%
157	Dwarfism	8.5%
158	MELAS Syndrome	8.4%
159	Renal tubular acidosis	8.4%
160	Familial Periodic Paralysis	8.3%
161	Fibromyalgia	8.2%
162	Polymyalgia Rheumatica	8.2%
163	Hypercholesterolemia	8.2%
164	Hyperlipoproteinemias	8.2%
165	Hypertriglyceridemia	8.2%
166	Melorheostosis	8.2%
167	Nesidioblastosis	8.2%
168	Osteopetrosis	8.2%
169	Spondylolisthesis	8.2%
170	Metatarsalgia	8.2%
171	Arthritis, Gouty	8.1%
172	Myelinolysis, Central Pontine	8.1%
173	Glycosuria	7.9%
174	Reye Syndrome	7.9%
175	Acromegaly	7.9%
176	Joint Tuberculosis	7.9%
177	Tuberculosis, Osteoarticular	7.9%
178	Bone Tuberculosis	7.9%
179	Hepatic Encephalopathy	7.9%
180	Fabry Disease	7.9%
181	Neuronal Ceroid-Lipofuscinoses	7.7%
182	Adrenoleukodystrophy	7.5%
183	HIV Wasting Syndrome	7.5%
184	Acidosis, Respiratory	7.4%
185	Adiposis Dolorosa	7.4%
186	Alkalosis, Respiratory	7.4%
187	Zellweger Syndrome	7.4%
188	Alkaptonuria	7.4%
189	Glycogen Storage Disease	7.4%
190	Hypophosphatasia	7.4%
191	Insulin Resistance	7.4%
192	Propionic acidemia	7.4%
193	Dihydropyrimidine Dehydrogenase Deficiency	7.4%
194	Cystinosis	7.4%
195	HIV-Associated Lipodystrophy Syndrome	7.3%
196	Menkes Kinky Hair Syndrome	7.3%
197	Craniosynostosis	7.3%
198	Syndactyly	7.3%
199	Brachycephaly	7.3%
200	Arthritis, Psoriatic	7.2%
201	Mucopolysaccharidosis III	6.9%
202	Acrocephalosyndactylia	6.8%
203	Hepatolenticular Degeneration	6.8%
204	Arthritis	6.8%
205	Bursitis	6.8%
206	Child Nutrition Disorders	6.8%
207	Hypervitaminosis A	6.8%
208	Infant Nutrition Disorders	6.8%
209	Joint Instability	6.8%
210	Myofascial Pain Syndromes	6.8%
211	Rhabdomyolysis	6.8%
212	Synovitis	6.8%
213	Joint laxity	6.8%
214	Polyarthritis	6.8%
215	Malnutrition	6.8%
216	Frozen shoulder	6.8%
217	Patellofemoral Pain Syndrome	6.8%
218	Porphyrias, Hepatic	6.7%
219	Refsum Disease	6.7%
220	Rheumatic Fever	6.7%
221	Hip Contracture	6.7%
222	Periarthritis	6.7%
223	Ischemic contracture	6.7%
224	Arthritis, Reactive	6.6%
225	Wernicke Encephalopathy	6.6%
226	Necrobiosis Lipoidica Diabeticorum	6.6%
227	Fanconi Anemia	6.6%
228	Glycosuria, Renal	6.5%
229	Temporomandibular Joint Disorders	6.4%
230	Hypokalemic periodic paralysis	6.2%
231	Gestational Diabetes	6.1%
232	Latent Autoimmune Diabetes in Adults	6.1%
233	Glycogen Storage Disease Type I	6.1%
234	Glycogen Storage Disease Type V	6.1%
235	Kearns-Sayre syndrome	6.1%
236	Diabetes Mellitus, Experimental	6%
237	Osteogenesis Imperfecta	6%
238	Goldenhar Syndrome	6%
239	Nephrocalcinosis	5.9%
240	Tetany	5.9%
241	Mastoiditis	5.9%
242	Poland Syndrome	5.9%
243	Petrositis	5.9%
244	Cerebral Amyloid Angiopathy	5.8%
245	Osteoarthritis, Knee	5.8%
246	Talipes	5.7%
247	Mandibulofacial Dysostosis	5.7%
248	Rheumatoid Arthritis	5.7%
249	Juvenile arthritis	5.7%
250	Friedreich Ataxia	5.6%
251	Temporomandibular Joint Dysfunction Syndrome	5.6%
252	Compartment syndromes	5.2%
253	Maxillary Diseases	5.2%
254	Tendinitis	5.2%
255	Tendinopathy	5.2%
256	Hemarthrosis	5.1%
257	Myositis	5.1%
258	Tietze's Syndrome	5.1%
259	Limb Deformities, Congenital	5.1%
260	Isaacs syndrome	5.1%
261	Craniofacial Abnormalities	5.1%
262	Myotonic Disorders	5.1%
263	Kernicterus	5%
264	Primary amyloidosis	5%
265	Variegate Porphyria	4.9%
266	Acute intermittent porphyria	4.9%
267	Porphyria Cutanea Tarda	4.9%
268	Sjogren-Larsson Syndrome	4.9%
269	Renal Aminoacidurias	4.9%
270	Fanconi Syndrome	4.9%
271	Pseudohypoaldosteronism	4.9%
272	Liddle Syndrome	4.9%
273	Canavan Disease	4.9%
274	Alexander Disease	4.9%
275	Mucopolysaccharidosis II	4.8%
276	Rubinstein-Taybi Syndrome	4.8%
277	Palatal Neoplasms	4.7%
278	Rheumatoid Nodule	4.6%
279	Marfan Syndrome	4.5%
280	Ataxia Telangiectasia	4.5%
281	Basal Cell Nevus Syndrome	4.5%
282	Bunion	4.4%
283	Congenital clubfoot	4.4%
284	Deficiency Diseases	4.4%
285	Fibrodysplasia Ossificans Progressiva	4.4%
286	Myoglobinuria	4.4%
287	Myositis Ossificans	4.4%
288	Starvation	4.4%
289	Tenosynovitis	4.4%
290	Vertical Talus	4.4%
291	Sacroiliitis	4.4%
292	Refeeding Syndrome	4.4%
293	Optic Atrophy, Hereditary, Leber	4.4%
294	Amyotrophic Lateral Sclerosis	4.3%
295	Medial Tibial Stress Syndrome	4.1%
296	Frontotemporal dementia	4.1%
297	Cystinuria	4%
298	Muscle Cramp	4%
299	Xeroderma Pigmentosum	4%
300	Eosinophilia-Myalgia Syndrome	4%
301	Gastroschisis	4%
302	Muscle Rigidity	4%
303	Muscle Spasticity	4%
304	Cogwheel Rigidity	4%
305	Nuchal Rigidity	4%
306	Felty Syndrome	3.8%
307	Jaw Abnormalities	3.8%
308	CREST Syndrome	3.7%
309	Chronic Fatigue Syndrome	3.5%
310	Prognathism	3.4%
311	Nail-Patella Syndrome	3.4%
312	Nose Neoplasms	3.4%
313	Arthritis, Infectious	3.4%
314	Giant Cell Epulis	3.4%
315	Muscle Weakness	3.4%
316	Musculoskeletal Pain	3.4%
317	Anterior Compartment Syndrome	3.3%
318	Enthesopathy	3.3%
319	Arthritis, Experimental	3.3%
320	Abdominal Compartment Syndrome	3.3%
321	Albinism	3.3%
322	Arthralgia	3.3%
323	Polyarthralgia	3.3%
324	Amelia	3.3%
325	Arachnodactyly	3.3%
326	Ectromelia	3.3%
327	Hemimelia	3.3%
328	Phocomelia	3.3%
329	Sirenomelia	3.3%
330	Polymyositis	3.3%
331	Polydactyly	3.3%
332	Brachydactyly	3.3%
333	Plagiocephaly	3.3%
334	Lower Extremity Deformities, Congenital	3.3%
335	Upper Extremity Deformities, Congenital	3.3%
336	Kwashiorkor	3.3%
337	Magnesium Deficiency	3.3%
338	Potassium Deficiency	3.3%
339	Protein Deficiency	3.3%
340	Avitaminosis	3.3%
341	Rheumatoid Vasculitis	3.3%
342	Laryngomalacia	2.9%
343	Sicca Syndrome	2.9%
344	Sjogren's Syndrome	2.9%
345	Myalgia	2.8%
346	Hip Dislocation	2.7%
347	Shoulder Dislocation	2.7%
348	Hip Dysplasia	2.7%
349	Ascorbic Acid Deficiency	2.7%
350	Vitamin A Deficiency	2.7%
351	Vitamin D Deficiency	2.7%
352	Vitamin E Deficiency	2.7%
353	Marasmus	2.7%
354	Ichthyosis, X-Linked	2.7%
355	Muscular Dystrophy	2.7%
356	Orbital Myositis	2.7%
357	Dupuytren Contracture	2.7%
358	Pyomyositis	2.6%
359	Micrognathism	2.6%
360	Pierre Robin Syndrome	2.6%
361	Myotonic Dystrophy	2.6%
362	Folic Acid Deficiency	2.5%
363	Pellagra	2.5%
364	Thiamine Deficiency	2.5%
365	Vitamin B 12 Deficiency	2.5%
366	Vitamin B 6 Deficiency	2.5%
367	Pyridoxine Deficiency	2.5%
368	Retrognathia	2.4%
369	Beriberi	2.3%
370	Maxillofacial Abnormalities	2.2%
371	Myotonia Congenita	2.2%
372	Bronchomalacia	2.2%
373	Tracheomalacia	2.2%
374	Microcephaly	2.2%
375	Macrocephaly	2.2%
376	Shoulder Pain	2.2%
377	Obesity	2.2%
378	Welander Distal Myopathy	2%
379	Obesity, Abdominal	1.9%
380	Cleft Palate	1.9%
381	Anemia, Pernicious	1.7%
382	Dermatomyositis	1.7%
383	Noonan Syndrome	1.7%
384	Vitamin K Deficiency	1.7%
385	Muscular Dystrophy, Duchenne	1.6%
386	Porencephaly	1.6%
387	Pediatric Obesity	1.6%
388	Scurvy	1.5%
389	Holoprosencephaly	1.5%
390	Prader-Willi Syndrome	1.4%
391	Radicular Cyst	1.2%
392	Subacute Combined Degeneration	1%

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