MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

AIDS Dementia Complex

(UMLS:C0001849)

Definition:: A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
UMLS ID:: C0001849
MeSH ID:: D015526

Classification 1:

Name:

Virus Diseases
MeSH Tree Number(s):: C02.782.815.616.400.049|C02.800.801.400.070

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.380.070

Classification 3:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.673.480.070

Classification 4:

Name:

Mental Disorders
MeSH Tree Number(s):: F03.615.400.050

Synonym(s)

AIDS Dementia Complex

ADC - Acquired immune deficiency syndrome dementia complex

AIDS - Acquired immune deficiency syndrome dementia complex

AIDS DEMENTIA

AIDS Dementia

AIDS dementia

AIDS dementia complex

AIDS with dementia, NOS

Acquired immune deficiency syndrome dementia complex

10.

Acquired immune deficiency syndrome-related dementia

11.

Aids dementia complex

12.

Dementia associated with AIDS

13.

Dementia associated with acquired immunodeficiency syndrome

14.

Dementia in human immunodeficiency virus [HIV] disease

15.

HIV dementia

16.

HIV disease; dementia (etiology)

17.

HIV disease; dementia (manifestation)

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Raltegravir Potassium	FAERS: 1		US FAERS
2	Tenofovir	FAERS: 1		OFFSIDES US FAERS
3	abacavir, lamivudine drug combination	FAERS: 1		US FAERS
4	Baclofen			OFFSIDES
5	Cocaine		11519485	CTD
6	Enalapril			OFFSIDES
7	Famotidine			OFFSIDES
8	Lopinavir/Ritonavir			OFFSIDES
9	Maraviroc			OFFSIDES
10	Methamphetamine		11519485	CTD
11	Stavudine		19139369	CTD
12	Warfarin			OFFSIDES
13	Zidovudine		1362818 2510843	CTD
14	abacavir			SIDER
15	oxybutynin			OFFSIDES
16	reviparin			OFFSIDES
17	tipranavir			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	HIV Seropositivity	37.4%
2	Acquired Immunodeficiency Syndrome	37%
3	AIDS related complex	37%
4	HIV Wasting Syndrome	30.1%
5	AIDS-Associated Nephropathy	30%
6	HIV-Associated Lipodystrophy Syndrome	27.1%
7	Kluver-Bucy Syndrome	27%
8	Creutzfeldt-Jakob disease	26.1%
9	Lewy Body Disease	26.1%
10	Dementia, Vascular	25.5%
11	Presenile dementia	24.9%
12	Senile dementia	24.9%
13	Huntington Disease	24.9%
14	AIDS-Related Opportunistic Infections	23.3%
15	Pick Disease of the Brain	16.7%
16	Frontotemporal dementia	16.3%
17	Leukoencephalopathy, Progressive Multifocal	15.8%
18	Simian Acquired Immunodeficiency Syndrome	14%
19	Meningoencephalitis	13.8%
20	Subdural Effusion	12.6%
21	Murine Acquired Immunodeficiency Syndrome	12.5%
22	Subacute Sclerosing Panencephalitis	12.5%
23	Condylomata Acuminata	12.4%
24	Rift Valley Fever	12.1%
25	Dandy-Walker Syndrome	12.1%
26	Chronic Fatigue Syndrome	12%
27	West Nile Fever	11.7%
28	Hepatitis E	11.6%
29	Akinetic Mutism	11.4%
30	Anoxic Encephalopathy	11.4%
31	Basal Ganglia Diseases	11.4%
32	Brain Damage, Chronic	11.4%
33	Cerebellar Diseases	11.4%
34	Encephalitis	11.4%
35	Encephalomalacia	11.4%
36	Epilepsy	11.4%
37	Hydrocephalus	11.4%
38	Congenital Hydrocephalus	11.4%
39	Hypothalamic Diseases	11.4%
40	Thalamic Diseases	11.4%
41	Intracranial Hypertension	11.4%
42	Aura	11.4%
43	Leukoencephalopathy	11.4%
44	Neuroaxonal Dystrophies	11.4%
45	Headache Disorders	11.4%
46	Intracranial Hypotension	11.4%
47	Brain Edema	11.4%
48	Brain Hypoxia	11.4%
49	Aqueductal Stenosis	11.4%
50	HTLV-I Infections	11.4%
51	Basal Ganglia Cerebrovascular Disease	11.4%
52	Multiple System Atrophy	11.4%
53	Encephalomyelitis	11.3%
54	Posterior Leukoencephalopathy Syndrome	11.3%
55	Posterior reversible encephalopathy syndrome	11.3%
56	Pneumocephalus	11.3%
57	Amnesia, Transient Global	11.2%
58	Brain Abscess	11%
59	Dengue Fever	10.9%
60	Yellow Fever	10.9%
61	Hemorrhagic Fever, Crimean	10.9%
62	Epilepsy, Post-Traumatic	10.8%
63	Parkinsonian Disorders	10.7%
64	Orthomyxoviridae Infections	10.2%
65	Picornaviridae Infections	10.2%
66	Reoviridae Infections	10.2%
67	Leukomalacia, Periventricular	10.2%
68	Vascular Headaches	10%
69	Brain Diseases, Metabolic	9.9%
70	Cerebrovascular Disorders	9.9%
71	Cerebrovascular Insufficiency	9.9%
72	Hypoxia-Ischemia, Brain	9.9%
73	Cognition Disorders	9.9%
74	Genital Herpes	9.9%
75	Arbovirus Infections	9.9%
76	Brain Injuries	9.9%
77	Hemorrhagic Fever, American	9.8%
78	Lassa Fever	9.8%
79	Brain Neoplasms	9.8%
80	Myoclonic Epilepsy	9.7%
81	Epilepsy, Temporal Lobe	9.7%
82	Epilepsy, Rolandic	9.7%
83	Benign Rolandic Epilepsy	9.7%
84	Lupus Vasculitis, Central Nervous System	9.6%
85	Phlebotomus Fever	9.5%
86	Cerebellar Neoplasms	9.3%
87	Meige Syndrome	9.3%
88	Cerebral Ventriculitis	9.3%
89	Ataxia Telangiectasia	9.1%
90	Brain Death	9.1%
91	Warts	9.1%
92	Marchiafava-Bignami Disease	8.9%
93	Parkinson Disease	8.8%
94	Epidural Abscess	8.7%
95	Basal Ganglia Hemorrhage	8.7%
96	Leukoencephalitis, Acute Hemorrhagic	8.7%
97	Ocular Motility Disorders	8.6%
98	Cyclophoria	8.6%
99	Poliomyelitis	8.6%
100	Stiff-Person Syndrome	8.5%
101	Lymphopenia	8.5%
102	Hepatitis, Viral, Human	8.4%
103	Myelitis	8.4%
104	Amblyopia	8.4%
105	Viremia	8.4%
106	Dystonia Musculorum Deformans	8.3%
107	Auditory Perceptual Disorders	8.3%
108	Meningitis	8.3%
109	Movement Disorders	8.3%
110	Pachymeningitis	8.3%
111	Spinal Cord Diseases	8.3%
112	Hepatitis C	8.2%
113	Sleep Wake Disorders	8.2%
114	Progressive supranuclear palsy	8.2%
115	Juvenile Myoclonic Epilepsy	8.1%
116	Myoclonic Epilepsies, Progressive	8.1%
117	Hemorrhagic Fever with Renal Syndrome	7.9%
118	Pseudorabies	7.9%
119	Neuroleptic Malignant Syndrome	7.8%
120	Myelinolysis, Central Pontine	7.8%
121	Pituitary Adenoma	7.8%
122	Pituitary Neoplasms	7.8%
123	Neurotic Disorders	7.8%
124	Consciousness Disorders	7.8%
125	Depressed Level of Consciousness	7.8%
126	Striatonigral Degeneration	7.8%
127	Opportunistic Infections	7.6%
128	Pituitary Apoplexy	7.6%
129	Vasculitis, Central Nervous System	7.6%
130	Cerebral Palsy	7.6%
131	Epilepsies, Partial	7.6%
132	Epilepsy, Generalized	7.6%
133	Pseudotumor Cerebri	7.6%
134	Hypertensive Encephalopathy	7.6%
135	Simple Partial Seizures	7.6%
136	Epilepsy, Reflex	7.6%
137	Headache Disorders, Primary	7.6%
138	Headache Disorders, Secondary	7.6%
139	Medication overuse headache	7.6%
140	Brain Infarction	7.5%
141	Zika Virus Infection	7.5%
142	Limbic Encephalitis	7.5%
143	Hepatolenticular Degeneration	7.5%
144	Agammaglobulinemia	7.5%
145	Hepatitis, Viral, Animal	7.4%
146	Putaminal Hemorrhage	7.4%
147	Pneumonia, Viral	7.4%
148	Amnesia	7.3%
149	Central Nervous System Infection	7.3%
150	Delirium	7.3%
151	Dissociative Amnesia	7.3%
152	Global Amnesia	7.3%
153	Brain Hemorrhage, Traumatic	7.2%
154	Infarction, Middle Cerebral Artery	7.1%
155	Infarction, Anterior Cerebral Artery	7.1%
156	Infarction, Posterior Cerebral Artery	7.1%
157	Epstein-Barr Virus Infections	7.1%
158	Carotid Artery Injuries	7.1%
159	Encephalomyelitis, Acute Disseminated	7.1%
160	Restless Legs Syndrome	7%
161	Shy-Drager Syndrome	7%
162	Lafora Disease	6.8%
163	Unverricht-Lundborg Syndrome	6.8%
164	Pituitary Diseases	6.7%
165	Miller Fisher Syndrome	6.7%
166	MPTP Poisoning	6.6%
167	Toxoplasmosis, Cerebral	6.6%
168	Prion Diseases	6.6%
169	Hepatitis A	6.6%
170	Carotid Artery Diseases	6.5%
171	Brain Ischemia	6.5%
172	Cerebrovascular accident	6.5%
173	Vasospasm, Intracranial	6.5%
174	Intracranial Arterial Diseases	6.5%
175	Brain Injuries, Diffuse	6.5%
176	Traumatic Brain Injury	6.5%
177	Cerebellar Ataxia	6.5%
178	Supratentorial Neoplasms	6.5%
179	Subacute Combined Degeneration	6.3%
180	Canavan Disease	6.3%
181	Alexander Disease	6.3%
182	Persistent Vegetative State	6.3%
183	Cerebral Infarction	6.2%
184	Brain Stem Infarctions	6.2%
185	Ophthalmoplegic Migraine	6.2%
186	Moyamoya Disease	6.2%
187	Hepatitis B	6.2%
188	Molluscum Contagiosum	6.2%
189	Paraneoplastic Cerebellar Degeneration	6.2%
190	Spinal Muscular Atrophy	6.2%
191	Progressive Muscular Atrophy	6.2%
192	Meningitis, Bacterial	6.1%
193	Meningitis, Fungal	6.1%
194	Myelitis, Transverse	6%
195	Kernicterus	6%
196	Friedreich Ataxia	6%
197	Spinal Cord Injuries	5.9%
198	Polyradiculoneuropathy	5.9%
199	Polyradiculoneuritis	5.9%
200	Amyotrophic Lateral Sclerosis	5.9%
201	Wernicke Encephalopathy	5.9%
202	Asterixis	5.8%
203	Ballismus	5.8%
204	Separation Anxiety Disorder	5.7%
205	Reye Syndrome	5.7%
206	Enterovirus Infections	5.7%
207	Flavivirus Infections	5.7%
208	Paramyxoviridae Infections	5.7%
209	Cardiovirus Infections	5.7%
210	Rhabdoviridae Infections	5.7%
211	Intracranial Embolism and Thrombosis	5.7%
212	Hepatic Encephalopathy	5.7%
213	Post-Traumatic Headache	5.7%
214	Tension Headache	5.7%
215	Epilepsy, Complex Partial	5.7%
216	Migraine Disorders	5.7%
217	Abdominal Migraine	5.7%
218	Status Migrainosus	5.7%
219	Cervicogenic Headache	5.7%
220	Anxiety Disorders	5.6%
221	Autoimmune Diseases	5.6%
222	Avoidant Personality Disorder	5.6%
223	Dissociative disorder	5.6%
224	Frigidity	5.6%
225	Hypersensitivity	5.6%
226	Hypoactive Sexual Desire Disorder	5.6%
227	Immunoproliferative Disorders	5.6%
228	Disruptive, Impulse Control, and Conduct Disorders	5.6%
229	Intermittent Explosive Disorder	5.6%
230	Kleptomania	5.6%
231	Narcissistic Personality Disorder	5.6%
232	Personality Disorders	5.6%
233	Sexual Aversion Disorder	5.6%
234	Somatoform Disorder	5.6%
235	Dissociation	5.6%
236	Motor Disorders	5.6%
237	Mood Disorders	5.6%
238	Schizophrenia Spectrum and Other Psychotic Disorders	5.6%
239	Immune reconstitution syndrome	5.6%
240	Neurodevelopmental Disorders	5.6%
241	Immune Reconstitution Inflammatory Syndrome	5.6%
242	Feeding and Eating Disorders	5.6%
243	Lateral Medullary Syndrome	5.6%
244	Job Syndrome	5.6%
245	Erythema Infectiosum	5.5%
246	Alexia, Pure	5.3%
247	Adrenoleukodystrophy	5.3%
248	Epidermodysplasia Verruciformis	5.3%
249	Parasomnia	5.3%
250	Dyssomnias	5.3%
251	Herpesviridae Infections	5.2%
252	Polyomavirus Infections	5.2%
253	Subarachnoid Hemorrhage, Traumatic	5.2%
254	Carotid Artery, Internal, Dissection	5.2%
255	Mitochondrial Encephalomyopathies	5.2%
256	MELAS Syndrome	5.2%
257	Brain Diseases, Metabolic, Inborn	5.1%
258	Cranial nerve diseases	5.1%
259	Demyelinating Diseases	5.1%
260	Demyelination	5.1%
261	Neuromuscular Diseases	5.1%
262	Chronobiology Disorders	5.1%
263	Foot-and-Mouth Disease	5.1%
264	Myasthenia Gravis	5%
265	Common Cold	5%
266	Influenza	5%
267	Catarrh	5%
268	Drug abuse	5%
269	Substance Dependence	5%
270	Substance-Related Disorders	5%
271	Drug Dependence	5%
272	Herpes Zoster Ophthalmicus	4.9%
273	Empty Sella Syndrome	4.9%
274	Hyperpituitarism	4.9%
275	Hypopituitarism	4.9%
276	Hypophysitis	4.9%
277	Chronic granulomatous disease	4.9%
278	Spinal Cord Neoplasms	4.9%
279	Arachnoiditis	4.9%
280	Aseptic Meningitis	4.9%
281	Syringomyelia	4.9%
282	Essential Tremor	4.9%
283	Familial Tremor	4.9%
284	Pneumorrhachis	4.9%
285	Writer's Cramp	4.9%
286	Transfusion Reaction	4.9%
287	Hypotensive Transfusion Reaction	4.9%
288	Cerebral Arterial Diseases	4.9%
289	Vertebrobasilar Insufficiency	4.9%
290	Basilar Artery Stenosis	4.9%
291	Vertebral Artery Stenosis	4.9%
292	Intracranial Hemorrhage, Hypertensive	4.9%
293	Transient Cerebral Ischemia	4.9%
294	Retrograde amnesia	4.9%
295	Amnesia, Anterograde	4.9%
296	Diffuse Axonal Injury	4.8%
297	Brain Stem Neoplasms	4.8%
298	Tuberculosis, Meningeal	4.8%
299	Motor Neuron Disease	4.8%
300	Keratitis, Herpetic	4.8%
301	Cytomegalovirus Retinitis	4.8%
302	Exanthema Subitum	4.8%
303	Cluster Headache	4.7%
304	Migraine with Aura	4.7%
305	Familial Hemiplegic Migraine	4.7%
306	Chronic Paroxysmal Hemicrania	4.7%
307	SUNCT Syndrome	4.7%
308	Paroxysmal Hemicrania	4.7%
309	Opsoclonus-Myoclonus Syndrome	4.7%
310	Akathisia, Drug-Induced	4.7%
311	Sleep Disorders, Circadian Rhythm	4.5%
312	Lambert-Eaton Myasthenic Syndrome	4.5%
313	Giant Cell Arteritis	4.5%
314	Temporal Arteritis	4.5%
315	Trauma, Nervous System	4.5%
316	Guillain-Barre Syndrome	4.4%
317	Vertebral Artery Dissection	4.4%
318	Neuromyelitis Optica	4.4%
319	Nervous System Neoplasms	4.4%
320	Neurologic Manifestations	4.4%
321	Neurotoxicity Syndromes	4.4%
322	Hepatitis C, Chronic	4.3%
323	Brain Contusion	4.3%
324	Carotid Stenosis	4.3%
325	Intracranial Aneurysm	4.3%
326	Central Nervous System Fungal Infections	4.3%
327	Conus Medullaris Syndrome	4.3%
328	Spinal Cord Vascular Diseases	4.3%
329	Intracranial Arteriosclerosis	4.3%
330	Cerebral Atherosclerosis	4.3%
331	Subarachnoid Hemorrhage	4.3%
332	Cerebral Arteriosclerosis	4.3%
333	Cerebral Hemorrhage	4.3%
334	Cerebral Thrombosis	4.2%
335	Intracranial Embolism	4.2%
336	Intracranial Thrombosis	4.2%
337	Dyskinesia, Drug-Induced	4.2%
338	Herpangina	4.2%
339	Glomerulonephritis, Membranoproliferative	4.2%
340	Myasthenia Gravis, Autoimmune, Experimental	4.1%
341	Brain Concussion	4.1%
342	Hyperprolactinemia	4.1%
343	Subclavian Steal Syndrome	4%
344	Choroid Plexus Papilloma	4%
345	Superinfection	4%
346	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	3.8%
347	Meningitis, Cryptococcal	3.8%
348	Autonomic Dysreflexia	3.8%
349	Complex Regional Pain Syndromes	3.8%
350	Meningitis, Listeria	3.8%
351	Carotid Artery Thrombosis	3.8%
352	Meningitis, Haemophilus	3.8%
353	Meningitis, Pneumococcal	3.8%
354	Central Nervous System Bacterial Infections	3.8%
355	Alice in Wonderland Syndrome	3.7%
356	Psychoses, Substance-Induced	3.7%
357	Uveomeningoencephalitic Syndrome	3.7%
358	Scrapie	3.7%
359	Central Cord Syndrome	3.7%
360	Autoimmune Lymphoproliferative Syndrome	3.7%
361	Multiple Sclerosis	3.7%
362	Chorea	3.7%
363	Eczema Herpeticum	3.7%
364	Burkitt Lymphoma	3.6%
365	Wiskott-Aldrich Syndrome	3.6%
366	Acromegaly	3.6%
367	Cerebral Amyloid Angiopathy	3.5%
368	Coxsackievirus Infections	3.5%
369	Rubella	3.5%
370	Coronavirus Infections	3.5%
371	Nipah Virus Infection	3.5%
372	Hydrophobia	3.5%
373	Sinus Thrombosis, Intracranial	3.5%
374	Fabry Disease	3.5%
375	Refsum Disease	3.4%
376	Peripheral Nerve Injuries	3.3%
377	Mental Retardation	3.3%
378	Mental deficiency	3.3%
379	Intellectual Disability	3.3%
380	Thrombocytopenic purpura	3.3%
381	Adjustment Disorders	3.3%
382	Affective Disorders, Psychotic	3.3%
383	Agoraphobia	3.3%
384	Anorexia Nervosa	3.3%
385	Antisocial Personality Disorder	3.3%
386	Bipolar Disorder	3.3%
387	Body Dysmorphic Disorders	3.3%
388	Borderline Personality Disorder	3.3%
389	Capgras Syndrome	3.3%
390	Child Behavior Disorders	3.3%
391	Developmental Disabilities	3.3%
392	Child Development Disorders, Pervasive	3.3%
393	Claustrophobia	3.3%
394	Conversion disorder	3.3%
395	Cyclothymic Disorder	3.3%
396	Dependent Personality Disorder	3.3%
397	Depressive disorder	3.3%
398	Developmental Coordination Disorder	3.3%
399	Exhibitionism	3.3%
400	Factitious Disorders	3.3%
401	Firesetting Behavior	3.3%
402	Head Banging	3.3%
403	Histrionic Personality Disorder	3.3%
404	Hypochondriasis	3.3%
405	Immune Complex Diseases	3.3%
406	Masochism	3.3%
407	Melancholia	3.3%
408	Motor Skills Disorders	3.3%
409	Dissociative Identity Disorder	3.3%
410	Neurasthenia	3.3%
411	Obsessive-Compulsive Disorder	3.3%
412	Oppositional Defiant Disorder	3.3%
413	Panic Disorder	3.3%
414	Paranoid Personality Disorder	3.3%
415	Pedophilia	3.3%
416	Pseudodementia	3.3%
417	Psychotic Disorders	3.3%
418	Sadism	3.3%
419	Schizoaffective Disorder	3.3%
420	Schizoid Personality Disorder	3.3%
421	Schizophrenia	3.3%
422	Schizophrenia, Childhood	3.3%
423	Schizotypal Personality Disorder	3.3%
424	Stereotypic Movement Disorder	3.3%
425	Transvestism	3.3%
426	Trichotillomania	3.3%
427	Voyeurism	3.3%
428	Antiphospholipid Syndrome	3.3%
429	Attention Deficit and Disruptive Behavior Disorders	3.3%
430	Hyperkinetic Heart Syndrome	3.3%
431	Reactive Attachment Disorder	3.3%
432	Sexual and Gender Disorders	3.3%
433	Latex allergy	3.3%
434	Gender Dysphoria	3.3%
435	Paranoia	3.3%
436	Compulsive Personality Disorder	3.3%
437	Bulimia Nervosa	3.3%
438	Jet Lag Syndrome	3.3%
439	Autoimmune thrombocytopenia	3.3%
440	Immune thrombocytopenic purpura	3.3%
441	Sleep Talking	3.3%
442	Sleep Disorders, Intrinsic	3.3%
443	Alcohol Withdrawal Delirium	3.3%
444	Herpes Labialis	3.3%
445	Hepatitis B, Chronic	3.2%
446	Torticollis	3.2%
447	Sexually Transmitted Diseases	3.2%
448	Cavernous Sinus Thrombosis	3.2%
449	Sagittal Sinus Thrombosis	3.2%
450	Hematoma, Subdural	3.2%
451	Hematoma, Epidural, Cranial	3.2%
452	Bell Palsy	3.1%
453	Galactosemias	3.1%
454	Urea Cycle Disorders, Inborn	3.1%
455	Tyrosinemias	3.1%
456	Porcine Reproductive and Respiratory Syndrome	3.1%
457	Cytomegalovirus Infections	3%
458	Smallpox	3%
459	Varicella Zoster Virus Infection	3%
460	Mutism	3%
461	Selective Mutism	3%
462	Botulism	2.9%
463	Central Nervous System Cysts	2.9%
464	Environmental Illness	2.9%
465	Primary amyloidosis	2.9%
466	Monoclonal Gammopathy of Undetermined Significance	2.9%
467	Olfactory Nerve Injuries	2.9%
468	Neuritis, Autoimmune, Experimental	2.9%
469	Sleep Bruxism	2.9%
470	Lupus Erythematosus, Systemic	2.9%
471	Lymphoproliferative Disorders	2.9%
472	Marijuana Abuse	2.9%
473	Opioid-Related Disorders	2.9%
474	Nicotine Dependence	2.9%
475	Opioid abuse	2.9%
476	Phencyclidine Abuse	2.9%
477	Substance Abuse, Intravenous	2.9%
478	Substance Withdrawal Syndrome	2.9%
479	Tobacco Use Disorder	2.9%
480	Alcohol-Related Disorders	2.9%
481	Amphetamine-Related Disorders	2.9%
482	Cocaine-Related Disorders	2.9%
483	Overlap syndrome	2.9%
484	Causalgia	2.9%
485	Prolactinoma	2.8%
486	Growth Hormone-Secreting Pituitary Adenoma	2.8%
487	Homocystinuria	2.8%
488	Addison Disease	2.8%
489	Gambling	2.8%
490	Paraproteinemias	2.8%
491	Pemphigus	2.8%
492	Premature Ejaculation	2.8%
493	Erectile dysfunction	2.8%
494	Autoimmune thyroiditis	2.8%
495	Primary Adrenal Insufficiency	2.8%
496	Leigh Disease	2.8%
497	Nelson Syndrome	2.8%
498	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	2.8%
499	Autoimmune hepatitis	2.8%
500	Progressive bulbar palsy	2.8%
501	Bulbar palsy	2.8%
502	Spinal Cord Ischemia	2.8%
503	Tuberculosis, Central Nervous System	2.8%
504	Dysautonomia	2.8%
505	Retroviridae Infections	2.8%
506	Vagus Nerve Disorder	2.8%
507	Glossopharyngeal Neuralgia	2.8%
508	Abducens Nerve Diseases	2.8%
509	Heavy Metal Poisoning, Nervous System	2.8%
510	Neuromuscular Junction Diseases	2.8%
511	Tauopathies	2.8%
512	Trochlear Nerve Diseases	2.8%
513	Peripheral Nervous System Diseases	2.8%
514	Infectious Mononucleosis	2.7%
515	Hematoma, Subdural, Intracranial	2.7%
516	Hematoma, Subdural, Chronic	2.7%
517	Hematoma, Subdural, Acute	2.7%
518	Vesicular Stomatitis	2.7%
519	Asthma, Aspirin-Induced	2.6%
520	Multiple Sclerosis, Chronic Progressive	2.6%
521	Multiple Sclerosis, Relapsing-Remitting	2.6%
522	Tardive Dyskinesia	2.6%
523	Facial Nerve Injuries	2.6%
524	Menkes Kinky Hair Syndrome	2.6%
525	Horner Syndrome	2.6%
526	Sleep Deprivation	2.6%
527	Psychoses, Alcoholic	2.5%
528	Serum Sickness	2.5%
529	Neonatal Abstinence Syndrome	2.5%
530	Hypergammaglobulinemia	2.5%
531	Latent Autoimmune Diabetes in Adults	2.5%
532	Dermatitis Herpetiformis	2.5%
533	Kounis Syndrome	2.5%
534	Transfusion-Related Acute Lung Injury	2.5%
535	Dyspareunia	2.5%
536	Neuroaspergillosis	2.5%
537	Myopathy	2.4%
538	Optic Neuropathy	2.4%
539	Measles	2.4%
540	Pleurodynia, Epidemic	2.4%
541	Respiratory Syncytial Virus Infections	2.4%
542	Tuberous Sclerosis	2.4%
543	Facial Nerve Diseases	2.4%
544	Craniocerebral Trauma	2.4%
545	Multiple Myeloma	2.4%
546	Vestibulocochlear Nerve Diseases	2.4%
547	Decerebrate State	2.4%
548	Hemiparesis	2.4%
549	Hydranencephaly	2.4%
550	Meningism	2.4%
551	Neural Tube Defects	2.4%
552	Paresis	2.4%
553	Seizures	2.4%
554	Sensation Disorders	2.4%
555	Tethered Cord Syndrome	2.4%
556	Central Nervous System Neoplasms	2.4%
557	Complex partial seizures	2.4%
558	Iniencephaly	2.4%
559	Craniorachischisis	2.4%
560	Exencephaly	2.4%
561	Monoparesis	2.4%
562	Septo-Optic Dysplasia	2.4%
563	Cortical Dysplasia	2.4%
564	Neurogenic Inflammation	2.4%
565	Gait Disorders, Neurologic	2.4%
566	Neuromuscular Manifestations	2.4%
567	Malformations of Cortical Development	2.4%
568	Sweating, Gustatory	2.4%
569	Auriculotemporal Syndrome	2.4%
570	Carbamoyl-Phosphate Synthase I Deficiency Disease	2.3%
571	Reflex Sympathetic Dystrophy	2.3%
572	Nocturnal Myoclonus Syndrome	2.3%
573	Disorders of Excessive Somnolence	2.3%
574	Sleep Initiation and Maintenance Disorders	2.3%
575	Night Terrors	2.3%
576	Somnambulism	2.3%
577	Transient Insomnia	2.3%
578	Sleep Paralysis	2.3%
579	Chronic Insomnia	2.3%
580	REM Sleep Behavior Disorder	2.3%
581	Hypersomnia	2.3%
582	Zellweger Syndrome	2.3%
583	Alexia	2.3%
584	Dyslexia	2.3%
585	Dyscalculia	2.2%
586	Rheumatoid Arthritis	2.2%
587	Juvenile arthritis	2.2%
588	Graves Disease	2.2%
589	Enuresis	2.2%
590	Ophthalmoplegia	2.2%
591	External Ophthalmoplegia	2.2%
592	Anti-Glomerular Basement Membrane Disease	2.2%
593	anaphylaxis	2.2%
594	Combat Disorders	2.2%
595	Dysthymic Disorder	2.2%
596	Food Allergy	2.2%
597	Hysteria	2.2%
598	Schizophrenia, Catatonic	2.2%
599	Schizophrenia, Disorganized	2.2%
600	Post-Traumatic Stress Disorder	2.2%
601	Attention Deficit Disorder	2.2%
602	Seasonal Affective Disorder	2.2%
603	Conduct Disorder	2.2%
604	Social Communication Disorder	2.2%
605	Psychological Trauma	2.2%
606	Hoarding Disorder	2.2%
607	Phonological Disorder	2.2%
608	Anaphylactic shock	2.2%
609	POEMS Syndrome	2.2%
610	Neurosyphilis	2.2%
611	Glycogen storage disease type II	2.2%
612	Pupil Disorders	2.1%
613	Neurobehavioral Manifestations	2.1%
614	Gastroenteritis, Transmissible, of Swine	2.1%
615	Severe Acute Respiratory Syndrome	2.1%
616	Charcot-Marie-Tooth Disease	2.1%
617	Paraneoplastic Encephalomyelitis	2.1%
618	Anterior Spinal Artery Syndrome	2.1%
619	Mumps	2.1%
620	Sturge-Weber Syndrome	2.1%
621	Vertigo	2.1%
622	Alcohol-Induced Disorders, Nervous System	2.1%
623	Acrodynia	2%
624	Herpes Zoster Oticus	2%
625	Vocal Cord Paralysis	2%
626	Sezary Syndrome	2%
627	Lyme Neuroborreliosis	1.9%
628	Respiratory Hypersensitivity	1.9%
629	Waterhouse-Friderichsen Syndrome	1.9%
630	Chickenpox	1.9%
631	Sick Building Syndrome	1.9%
632	Multiple Chemical Sensitivity	1.9%
633	Alcohol Use Disorder	1.9%
634	Alcoholic Intoxication	1.9%
635	Heroin Dependence	1.9%
636	Morphine Dependence	1.9%
637	Plasmacytoma	1.9%
638	Tumor Lysis Syndrome	1.9%
639	Urticaria	1.9%
640	Alcohol abuse	1.9%
641	Vasculitis, Leukocytoclastic, Cutaneous	1.9%
642	Depression, Postpartum	1.9%
643	Voice Disorders	1.9%
644	Voice Disturbance	1.9%
645	Premenstrual Dysphoric Disorder	1.9%
646	Brachial Plexus Neuritis	1.9%
647	Neuralgic Amyotrophy	1.9%
648	HIV Infections	1.9%
649	Narcolepsy	1.8%
650	Kleine-Levin Syndrome	1.8%
651	Toxoplasmosis, Congenital	1.8%
652	Smith-Magenis syndrome	1.8%
653	Malaria, Cerebral	1.8%
654	Dural Arteriovenous Fistula	1.8%
655	Neurocysticercosis	1.8%
656	Myotonia Congenita	1.8%
657	Cerebrospinal Fluid Otorrhea	1.8%
658	Cerebrospinal Fluid Rhinorrhea	1.8%
659	Gait Ataxia	1.8%
660	Gaucher Disease	1.8%
661	Alcohol Withdrawal Seizures	1.8%
662	Myotonic Dystrophy	1.8%
663	Coma, Post-Head Injury	1.7%
664	Lymphoma	1.7%
665	Mastocytosis	1.6%
666	Drug Eruptions	1.6%
667	Reflex, Abnormal	1.6%
668	Hyporeflexia	1.6%
669	Hyperreflexia	1.6%
670	Hydrops Fetalis	1.6%
671	Tay-Sachs Disease	1.6%
672	Heavy Chain Disease	1.6%
673	Binge Drinking	1.6%
674	Neuritis	1.6%
675	Polyneuritis	1.6%
676	Radiculitis	1.6%
677	Polyneuropathy	1.6%
678	Mononeuritis	1.6%
679	Mononeuropathies	1.6%
680	Brachial Plexus Neuropathies	1.6%
681	Radiculopathy	1.6%
682	Mononeuropathy Multiplex	1.6%
683	Nerve Root Compression	1.6%
684	Granulomatosis with polyangiitis	1.6%
685	Dermatitis, Allergic Contact	1.6%
686	Akathisia	1.6%
687	Restlessness	1.6%
688	Psychomotor Agitation	1.6%
689	Autistic Disorder	1.6%
690	Milk Allergy	1.6%
691	Asperger Syndrome	1.6%
692	Schnitzler Syndrome	1.6%
693	Wheat Hypersensitivity	1.6%
694	Tarsal Tunnel Syndrome	1.6%
695	Cauda Equina Syndrome	1.6%
696	Cataplexy	1.6%
697	Optic Nerve Glioma	1.6%
698	Niemann-Pick Disease, Type C	1.6%
699	Alstrom Syndrome	1.5%
700	Gait Apraxia	1.5%
701	Cryoglobulinemia	1.5%
702	Felty Syndrome	1.5%
703	Lupus Nephritis	1.4%
704	Diurnal Enuresis	1.4%
705	Carpal Tunnel Syndrome	1.4%
706	Myositis	1.4%
707	Optic Atrophy	1.4%
708	Optic Neuritis	1.4%
709	Papilledema	1.4%
710	Strabismus	1.4%
711	Tolosa-Hunt Syndrome	1.4%
712	Isaacs syndrome	1.4%
713	Arsenic Poisoning	1.4%
714	Myotonic Disorders	1.4%
715	Myasthenic Syndromes, Congenital	1.4%
716	neurofibroma	1.4%
717	Sciatica	1.4%
718	Diabetic Neuropathies	1.4%
719	Facial Injuries	1.4%
720	Facial Neuralgia	1.4%
721	Diabetic Amyotrophy	1.4%
722	Diabetic Autonomic Neuropathy	1.4%
723	Manganese Poisoning	1.4%
724	Orthostatic intolerance	1.4%
725	Anosmia	1.4%
726	Ataxia	1.4%
727	Athetosis	1.4%
728	Catalepsy	1.4%
729	Dystonia	1.4%
730	Hemiplegia	1.4%
731	Locked-In Syndrome	1.4%
732	Meningeal Neoplasms	1.4%
733	Meningomyelocele	1.4%
734	Muscle Hypertonia	1.4%
735	Muscle hypotonia	1.4%
736	Myoclonus	1.4%
737	Myotonia	1.4%
738	Neuralgia	1.4%
739	Paraplegia	1.4%
740	Pseudobulbar Palsy	1.4%
741	Quadriplegia	1.4%
742	Spasm	1.4%
743	Spastic Paraplegia	1.4%
744	Status Epilepticus	1.4%
745	Taste Disorders	1.4%
746	Tremor	1.4%
747	Spina Bifida	1.4%
748	Monoplegia	1.4%
749	Hypokinesia	1.4%
750	Paraparesis	1.4%
751	Bradykinesia	1.4%
752	Waxy flexibility	1.4%
753	Action Tremor	1.4%
754	Resting Tremor	1.4%
755	Dysosmia	1.4%
756	Quadriparesis	1.4%
757	Mercury Poisoning, Nervous System	1.4%
758	Olfaction Disorders	1.4%
759	Myokymia	1.4%
760	Lead Poisoning, Nervous System	1.4%
761	Vestibular Neuronitis	1.4%
762	Somatosensory Disorders	1.4%
763	Neuropathic pain	1.4%
764	Hyperkinesia	1.4%
765	Intention tremor	1.4%
766	Acoustic Neuroma	1.4%
767	Mastocytosis, Systemic	1.4%
768	Amyloid Neuropathies, Familial	1.4%
769	Dermatitis, Atopic	1.3%
770	Rheumatoid Vasculitis	1.3%
771	Hand-Arm Vibration Syndrome	1.3%
772	Vision Disorders	1.3%
773	Metamorphopsia	1.3%
774	Visual Impairment	1.3%
775	Fibromyalgia	1.3%
776	Optic Neuropathy, Ischemic	1.3%
777	Anterior Ischemic Optic Neuropathy	1.3%
778	Medial Tibial Stress Syndrome	1.3%
779	Facial Hemiatrophy	1.2%
780	Melkersson-Rosenthal Syndrome	1.2%
781	Mitochondrial Myopathies	1.2%
782	Anisocoria	1.2%
783	Confusion	1.2%
784	Facial paralysis	1.2%
785	Lethargy	1.2%
786	Memory Disorders	1.2%
787	Muscle Cramp	1.2%
788	Perceptual Disorders	1.2%
789	Psychomotor Disorders	1.2%
790	Tonic Pupil	1.2%
791	Eosinophilia-Myalgia Syndrome	1.2%
792	Anhedonia	1.2%
793	Disorientation	1.2%
794	Facial Paresis	1.2%
795	Memory Loss	1.2%
796	Hemisensory Neglect	1.2%
797	Dysacusis	1.2%
798	Angioedema	1.2%
799	Anencephaly	1.2%
800	Meningocele	1.2%
801	Muscular Atrophy	1.2%
802	Respiratory Paralysis	1.2%
803	Encephalocele	1.2%
804	Hodgkin Disease	1.2%
805	Leukemia, Plasma Cell	1.2%
806	Lymphoma, Non-Hodgkin	1.2%
807	Tetany	1.2%
808	Leukemia, T-Cell	1.2%
809	Acute Generalized Exanthematous Pustulosis	1.2%
810	Leukemia, B-Cell	1.2%
811	Cubital Tunnel Syndrome	1.2%
812	Waldenstrom Macroglobulinemia	1.2%
813	Sicca Syndrome	1.2%
814	Sjogren's Syndrome	1.2%
815	Classical Lissencephalies and Subcortical Band Heterotopias	1.1%
816	Duane Retraction Syndrome	1.1%
817	Asthma	1.1%
818	Muscle Weakness	1.1%
819	Mobius Syndrome	1.1%
820	Catatonia	1.1%
821	Familial Periodic Paralysis	1.1%
822	Aphonia	1.1%
823	Dysphonia	1.1%
824	Composite Lymphoma	1.1%
825	Erythema Nodosum	1.1%
826	Sciatic Neuropathy	1.1%
827	Ulnar Neuropathies	1.1%
828	Lesion of Sciatic Nerve	1.1%
829	Ulnar Neuritis	1.1%
830	Radial nerve compression	1.1%
831	Radial Tunnel Syndrome	1.1%
832	Peroneal Neuropathies	1.1%
833	Radial Neuropathy	1.1%
834	Median Neuropathy	1.1%
835	Sciatic Nerve Palsy	1.1%
836	Femoral Neuropathy	1.1%
837	Tibial Neuropathy	1.1%
838	Ulnar Nerve Palsy	1.1%
839	Postural Orthostatic Tachycardia Syndrome	1.1%
840	Radial nerve palsy	1.1%
841	Dermatitis, Photoallergic	1.1%
842	Lymphangioleiomyomatosis	1.1%
843	Asthma, Exercise-Induced	1%
844	Status Asthmaticus	1%
845	Lymphoma, Follicular	1%
846	T-Cell Lymphoma	1%
847	Mantle cell lymphoma	1%
848	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1%
849	Leukemia, Large Granular Lymphocytic	1%
850	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1%
851	Aspergillosis, Allergic Bronchopulmonary	1%
852	Myalgia	1%
853	AIDS Dementia Complex	1%
854	Neuronal Ceroid-Lipofuscinoses	1%
855	Kearns-Sayre syndrome	1%
856	Optic Atrophy, Hereditary, Leber	0.9%
857	Thoracic Outlet Syndrome	0.9%
858	Esotropia	0.9%
859	Exotropia	0.9%
860	Hypotension, Orthostatic	0.9%
861	Sleep Apnea Syndromes	0.9%
862	Polymyositis	0.9%
863	Post-Exercise Hypotension	0.9%
864	Asthma, Occupational	0.9%
865	Trigeminal Nerve Disorder	0.9%
866	Dermal Sinus	0.9%
867	Dysgeusia	0.9%
868	Formication	0.9%
869	Hyperalgesia	0.9%
870	Hyperesthesia	0.9%
871	Hypesthesia	0.9%
872	Language Disorders	0.9%
873	Numbness	0.9%
874	Paresthesia	0.9%
875	Paraparesis, Spastic	0.9%
876	Spina Bifida Cystica	0.9%
877	Trismus	0.9%
878	Spina Bifida Occulta	0.9%
879	Epilepsia Partialis Continua	0.9%
880	Hypogeusia	0.9%
881	Meningeal Carcinomatosis	0.9%
882	Brown-Sequard Syndrome	0.9%
883	Lissencephaly	0.9%
884	Polymicrogyria	0.9%
885	Pachygyria	0.9%
886	Schizencephaly	0.9%
887	Lockjaw	0.9%
888	Allodynia	0.9%
889	Lead Poisoning, Nervous System, Childhood	0.9%
890	Lead Poisoning, Nervous System, Adult	0.9%
891	Periventricular Nodular Heterotopia	0.9%
892	Ageusia	0.9%
893	Farmer's Lung	0.9%
894	Angioedemas, Hereditary	0.9%
895	Aicardi's syndrome	0.9%
896	Hereditary Angioedema Type III	0.9%
897	Hereditary Angioedema Types I and II	0.9%
898	Lymphoma, T-Cell, Cutaneous	0.9%
899	Lymphoma, AIDS-Related	0.9%
900	Enteropathy-Associated T-Cell Lymphoma	0.9%
901	Primary Effusion Lymphoma	0.9%
902	Hay fever	0.9%
903	Rhinitis, Allergic, Perennial	0.9%
904	Hoarseness	0.9%
905	Cockayne Syndrome	0.9%
906	Toxic Epidermal Necrolysis	0.9%
907	Stevens-Johnson Syndrome	0.9%
908	Neurofibrosarcoma	0.9%
909	Mycosis Fungoides	0.9%
910	Lymphomatoid Papulosis	0.9%
911	Plasmablastic lymphoma	0.9%
912	Eye Injuries	0.8%
913	Muscular Dystrophy	0.8%
914	Congenital nystagmus	0.8%
915	Orbital Myositis	0.8%
916	Holoprosencephaly	0.8%
917	Diplopia	0.8%
918	Muscle Rigidity	0.8%
919	Muscle Spasticity	0.8%
920	Scotoma	0.8%
921	Photophobia	0.8%
922	Cogwheel Rigidity	0.8%
923	Hemifacial Spasm	0.8%
924	Amaurosis	0.8%
925	Blindness	0.8%
926	Nuchal Rigidity	0.8%
927	Pyomyositis	0.8%
928	Lymphomatoid Granulomatosis	0.8%
929	Agnosia	0.8%
930	Apraxias	0.8%
931	Hallucinations	0.8%
932	Hemianopsia	0.8%
933	Hyperacusis	0.8%
934	Tinnitus	0.8%
935	Visual Agnosia	0.8%
936	Anosognosia	0.8%
937	Wernicke-Korsakoff Syndrome	0.8%
938	Phonophobia	0.8%
939	Hearing Loss	0.8%
940	Polyradiculopathy	0.8%
941	Sarcopenia	0.8%
942	Color blindness	0.7%
943	Cri-du-Chat Syndrome	0.7%
944	Down Syndrome	0.7%
945	Trisomy 21	0.7%
946	Meningioma	0.7%
947	Williams Syndrome	0.7%
948	Microcephaly	0.7%
949	Macrocephaly	0.7%
950	Hypokalemic periodic paralysis	0.7%
951	Porencephaly	0.7%
952	Sleep Apnea, Obstructive	0.7%
953	Sleep Apnea, Central	0.7%
954	Trigeminal Neuralgia	0.7%
955	Agraphia	0.7%
956	Anomia	0.7%
957	Cluttering	0.7%
958	Language Development Disorders	0.7%
959	Speech Disorders	0.7%
960	Syncope	0.7%
961	Stupor	0.7%
962	Dysgraphia	0.7%
963	Presyncope	0.7%
964	Dyslalia	0.7%
965	Prader-Willi Syndrome	0.7%
966	Phantom pain	0.6%
967	Phantom Limb Pain	0.6%
968	Eye Burns	0.6%
969	Welander Distal Myopathy	0.6%
970	Amaurosis Fugax	0.6%
971	Blindness, Cortical	0.6%
972	Rett Syndrome	0.6%
973	Deafness	0.6%
974	Hearing Loss, Sudden	0.6%
975	Gerstmann Syndrome	0.6%
976	Hearing Loss, Bilateral	0.6%
977	Hearing Loss, High-Frequency	0.6%
978	Hearing Loss, Mixed Conductive-Sensorineural	0.6%
979	Prosopagnosia	0.6%
980	Apraxia, Ideomotor	0.6%
981	Charles Bonnet Syndrome	0.6%
982	Hearing Loss, Unilateral	0.6%
983	Complete Hearing Loss	0.6%
984	Alien Hand Syndrome	0.6%
985	Deaf Mutism	0.6%
986	Aphasia	0.6%
987	Articulation Disorders	0.6%
988	Echolalia	0.6%
989	Stuttering	0.6%
990	Dysphasia	0.6%
991	Dermatomyositis	0.6%
992	Corneal Scar	0.6%
993	Rubinstein-Taybi Syndrome	0.5%
994	Muscular Dystrophy, Duchenne	0.5%
995	Dysarthria	0.5%
996	Fragile X Syndrome	0.5%
997	Corneal Perforation	0.5%
998	Mucopolysaccharidosis II	0.4%

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