MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Spinal Muscular Atrophy

(UMLS:C0026847)

Definition:: A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary. (Adams et al., Principles of Neurology, 6th ed, p1089)
UMLS ID:: C0026847
MeSH ID:: D009134

Classification:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.854.468|C10.574.562.500|C10.668.467.500

Synonym(s)

Spinal Muscular Atrophy

SMA

SMA - Spinal muscular atrophy

SPINE MUSCLE ATROPHY

Spinal muscle degeneration

Spinal muscle wasting

Spinal muscular atrophy

Spinal muscular atrophy, NOS

Spinal muscular atrophy, unspecified

10.

atrophies muscular spinal

11.

atrophy muscular sma spinal

12.

atrophy muscular spinal

13.

atrophy spinal muscular

14.

inherited spinal muscular atrophy

15.

muscle spinal atrophy

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Valproic Acid	FAERS: 9	US FAERS
2	Sertraline	FAERS: 2	US FAERS
3	Acitretin	FAERS: 1	US FAERS
4	Atorvastatin	FAERS: 1	US FAERS
5	Dimethyl Fumarate	FAERS: 1	US FAERS
6	Docetaxel	FAERS: 1	US FAERS
7	Fingolimod Hydrochloride	FAERS: 1	US FAERS
8	Nadolol	FAERS: 1	US FAERS
9	Riluzole	FAERS: 1	US FAERS
10	Spironolactone	FAERS: 1	US FAERS
11	candesartan	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Amyotrophic Lateral Sclerosis	53.1%
2	Progressive bulbar palsy	48%
3	Bulbar palsy	48%
4	Stiff-Person Syndrome	40.8%
5	Myelitis	37.3%
6	Multiple System Atrophy	36.8%
7	Subacute Combined Degeneration	35.3%
8	Poliomyelitis	34.1%
9	Encephalomyelitis	33.8%
10	Prion Diseases	33.8%
11	Epidural Abscess	33.5%
12	Meningoencephalitis	33%
13	Parkinson Disease	31.9%
14	Spinal Cord Injuries	31.4%
15	Lewy Body Disease	30%
16	Syringomyelia	30%
17	Pneumorrhachis	30%
18	Ocular Motility Disorders	28.2%
19	Cyclophoria	28.2%
20	Spinal Cord Neoplasms	26.5%
21	Striatonigral Degeneration	26.5%
22	Cranial nerve diseases	26.3%
23	Demyelinating Diseases	26.3%
24	Demyelination	26.3%
25	Chronobiology Disorders	26.3%
26	Myelitis, Transverse	25.7%
27	Complex Regional Pain Syndromes	25.7%
28	Pneumocephalus	25.6%
29	Brain Diseases	25.4%
30	Meningitis	25.4%
31	Movement Disorders	25.4%
32	Pachymeningitis	25.4%
33	Neuromuscular Junction Diseases	25.4%
34	Tauopathies	25.4%
35	Peripheral Nervous System Diseases	25.4%
36	Chronic Fatigue Syndrome	25%
37	Polyradiculoneuropathy	24.6%
38	Polyradiculoneuritis	24.6%
39	Conus Medullaris Syndrome	24.3%
40	Spinal Cord Vascular Diseases	24.3%
41	Progressive supranuclear palsy	24%
42	Dystonia Musculorum Deformans	23.6%
43	Guillain-Barre Syndrome	23.3%
44	Shy-Drager Syndrome	23.2%
45	Subdural Effusion	23.2%
46	Parkinsonian Disorders	23.2%
47	Causalgia	23.1%
48	Dandy-Walker Syndrome	22.9%
49	Friedreich Ataxia	22.3%
50	Marchiafava-Bignami Disease	22.1%
51	Central Cord Syndrome	21.8%
52	Trauma, Nervous System	21.7%
53	Ophthalmoplegic Migraine	21.7%
54	Restless Legs Syndrome	21.6%
55	Peripheral Nerve Injuries	21.6%
56	Lambert-Eaton Myasthenic Syndrome	21.6%
57	Myasthenia Gravis	21.3%
58	Asterixis	21.3%
59	Ballismus	21.3%
60	Miller Fisher Syndrome	21.3%
61	Central Nervous System Infection	21.1%
62	Myopathy	21.1%
63	Nervous System Neoplasms	21.1%
64	Neurologic Manifestations	21.1%
65	Neurotoxicity Syndromes	21.1%
66	Huntington Disease	20.6%
67	Limbic Encephalitis	20.6%
68	Opsoclonus-Myoclonus Syndrome	20.3%
69	Autonomic Dysreflexia	20.3%
70	MPTP Poisoning	19.8%
71	Meige Syndrome	19.7%
72	Brachial Plexus Neuritis	19.7%
73	Neuralgic Amyotrophy	19.7%
74	Cerebral Ventriculitis	19.7%
75	Scrapie	19.6%
76	Leukoencephalitis, Acute Hemorrhagic	19.5%
77	Presenile dementia	19.3%
78	Senile dementia	19.3%
79	Meningitis, Bacterial	19.3%
80	Meningitis, Fungal	19.3%
81	Lafora Disease	19.3%
82	Unverricht-Lundborg Syndrome	19.3%
83	Leukoencephalopathy, Progressive Multifocal	19.2%
84	Brain Abscess	19.1%
85	Lupus Vasculitis, Central Nervous System	18.5%
86	Neuroleptic Malignant Syndrome	18.4%
87	Myelinolysis, Central Pontine	18.4%
88	Dementia, Vascular	18.3%
89	Epilepsy, Post-Traumatic	18.2%
90	Botulism	18.2%
91	Tarsal Tunnel Syndrome	18%
92	Cauda Equina Syndrome	18%
93	Posterior Leukoencephalopathy Syndrome	18%
94	Posterior reversible encephalopathy syndrome	18%
95	Reflex Sympathetic Dystrophy	17.9%
96	Spinal Cord Ischemia	17.9%
97	Sleep Wake Disorders	17.9%
98	Brain Injuries	17.8%
99	Brain Neoplasms	17.7%
100	Neuromuscular Diseases	17.5%
101	Encephalomyelitis, Acute Disseminated	17.2%
102	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	17.2%
103	Paraneoplastic Encephalomyelitis	17%
104	Dyskinesia, Drug-Induced	16.8%
105	Akinetic Mutism	16.7%
106	Anoxic Encephalopathy	16.7%
107	Arachnoiditis	16.7%
108	Basal Ganglia Diseases	16.7%
109	Brain Damage, Chronic	16.7%
110	Cerebellar Diseases	16.7%
111	Encephalitis	16.7%
112	Encephalomalacia	16.7%
113	Epilepsy	16.7%
114	Hydrocephalus	16.7%
115	Congenital Hydrocephalus	16.7%
116	Hypothalamic Diseases	16.7%
117	Aseptic Meningitis	16.7%
118	Neuritis	16.7%
119	Polyneuritis	16.7%
120	Radiculitis	16.7%
121	Thalamic Diseases	16.7%
122	Intracranial Hypertension	16.7%
123	Polyneuropathy	16.7%
124	Mononeuritis	16.7%
125	Aura	16.7%
126	Leukoencephalopathy	16.7%
127	Essential Tremor	16.7%
128	Neuroaxonal Dystrophies	16.7%
129	Familial Tremor	16.7%
130	Headache Disorders	16.7%
131	Mononeuropathies	16.7%
132	Intracranial Hypotension	16.7%
133	Brachial Plexus Neuropathies	16.7%
134	Radiculopathy	16.7%
135	Mononeuropathy Multiplex	16.7%
136	Nerve Root Compression	16.7%
137	Brain Edema	16.7%
138	Brain Hypoxia	16.7%
139	Aqueductal Stenosis	16.7%
140	Writer's Cramp	16.7%
141	Myotonia Congenita	16.6%
142	Paraneoplastic Cerebellar Degeneration	16.5%
143	Canavan Disease	16.5%
144	Alexander Disease	16.5%
145	Creutzfeldt-Jakob disease	16.5%
146	Basal Ganglia Cerebrovascular Disease	16.5%
147	Motor Neuron Disease	16.4%
148	Myoclonic Epilepsy	16.3%
149	Epilepsy, Temporal Lobe	16.3%
150	Epilepsy, Rolandic	16.3%
151	Benign Rolandic Epilepsy	16.3%
152	Cerebellar Neoplasms	16.2%
153	Tuberculosis, Meningeal	16.2%
154	Charcot-Marie-Tooth Disease	16.2%
155	Akathisia, Drug-Induced	16%
156	Acrodynia	15.9%
157	Hepatolenticular Degeneration	15.9%
158	Myotonic Dystrophy	15.7%
159	Olfactory Nerve Injuries	15.6%
160	Dysautonomia	15.3%
161	Vagus Nerve Disorder	15.3%
162	Glossopharyngeal Neuralgia	15.3%
163	Abducens Nerve Diseases	15.3%
164	Heavy Metal Poisoning, Nervous System	15.3%
165	Trochlear Nerve Diseases	15.3%
166	Neuromyelitis Optica	15.2%
167	Carpal Tunnel Syndrome	15.1%
168	Vascular Headaches	15.1%
169	Hypoxia-Ischemia, Brain	15%
170	Sciatica	14.9%
171	Sleep Disorders, Circadian Rhythm	14.9%
172	Chorea	14.8%
173	Anterior Spinal Artery Syndrome	14.8%
174	Brain Death	14.7%
175	Juvenile Myoclonic Epilepsy	14.7%
176	Myoclonic Epilepsies, Progressive	14.7%
177	Brain Hemorrhage, Traumatic	14.4%
178	Central Nervous System Cysts	14.4%
179	Myasthenia Gravis, Autoimmune, Experimental	14.2%
180	Leukomalacia, Periventricular	14.2%
181	Nocturnal Myoclonus Syndrome	13.9%
182	Toxoplasmosis, Cerebral	13.9%
183	Vasculitis, Central Nervous System	13.8%
184	Amblyopia	13.8%
185	Facial Nerve Injuries	13.6%
186	Cubital Tunnel Syndrome	13.6%
187	Brain Diseases, Metabolic	13.5%
188	Cerebrovascular Disorders	13.5%
189	Myositis	13.5%
190	Cerebrovascular Insufficiency	13.5%
191	Isaacs syndrome	13.5%
192	Dementia	13.5%
193	Myotonic Disorders	13.5%
194	Central Nervous System Fungal Infections	13.5%
195	Myasthenic Syndromes, Congenital	13.5%
196	Carotid Artery Injuries	13.5%
197	Diabetic Neuropathies	13.3%
198	Spinal Muscular Atrophy	13.3%
199	Diabetic Amyotrophy	13.3%
200	Diabetic Autonomic Neuropathy	13.3%
201	Progressive Muscular Atrophy	13.3%
202	Multiple Sclerosis	13.3%
203	Tuberous Sclerosis	13.3%
204	Neuralgia	13.2%
205	Neuropathic pain	13.2%
206	Brain Injuries, Diffuse	13.1%
207	Traumatic Brain Injury	13.1%
208	Cerebellar Ataxia	13.1%
209	Supratentorial Neoplasms	13.1%
210	Torticollis	13.1%
211	Basal Ganglia Hemorrhage	13%
212	Meningitis, Cryptococcal	12.9%
213	Pituitary Adenoma	12.9%
214	Pituitary Neoplasms	12.9%
215	Horner Syndrome	12.8%
216	Meningitis, Listeria	12.8%
217	Meningitis, Haemophilus	12.8%
218	Meningitis, Pneumococcal	12.8%
219	Frontotemporal dementia	12.8%
220	Neuritis, Autoimmune, Experimental	12.7%
221	Optic Neuropathy	12.7%
222	Cerebral Palsy	12.4%
223	Epilepsies, Partial	12.4%
224	Epilepsy, Generalized	12.4%
225	Pseudotumor Cerebri	12.4%
226	Sciatic Neuropathy	12.4%
227	Hypertensive Encephalopathy	12.4%
228	Ulnar Neuropathies	12.4%
229	Lesion of Sciatic Nerve	12.4%
230	Simple Partial Seizures	12.4%
231	Epilepsy, Reflex	12.4%
232	Ulnar Neuritis	12.4%
233	Radial nerve compression	12.4%
234	Radial Tunnel Syndrome	12.4%
235	Peroneal Neuropathies	12.4%
236	Radial Neuropathy	12.4%
237	Median Neuropathy	12.4%
238	Sciatic Nerve Palsy	12.4%
239	Femoral Neuropathy	12.4%
240	Tibial Neuropathy	12.4%
241	Ulnar Nerve Palsy	12.4%
242	Radial nerve palsy	12.4%
243	Headache Disorders, Primary	12.4%
244	Headache Disorders, Secondary	12.4%
245	Medication overuse headache	12.4%
246	Mitochondrial Encephalomyopathies	12.3%
247	Facial Nerve Diseases	12.3%
248	Craniocerebral Trauma	12.3%
249	Parasomnia	12.3%
250	Dyssomnias	12.3%
251	Persistent Vegetative State	12.2%
252	Vestibulocochlear Nerve Diseases	12.2%
253	Decerebrate State	12.2%
254	Hemiparesis	12.2%
255	Hydranencephaly	12.2%
256	Meningism	12.2%
257	Neural Tube Defects	12.2%
258	Paresis	12.2%
259	Seizures	12.2%
260	Sensation Disorders	12.2%
261	Tethered Cord Syndrome	12.2%
262	Central Nervous System Neoplasms	12.2%
263	Complex partial seizures	12.2%
264	Iniencephaly	12.2%
265	Craniorachischisis	12.2%
266	Exencephaly	12.2%
267	Monoparesis	12.2%
268	Septo-Optic Dysplasia	12.2%
269	Cortical Dysplasia	12.2%
270	Neurogenic Inflammation	12.2%
271	Gait Disorders, Neurologic	12.2%
272	Neuromuscular Manifestations	12.2%
273	Malformations of Cortical Development	12.2%
274	Ataxia Telangiectasia	12.1%
275	Sweating, Gustatory	12.1%
276	Auriculotemporal Syndrome	12.1%
277	Refsum Disease	12.1%
278	Subacute Sclerosing Panencephalitis	12%
279	Putaminal Hemorrhage	11.8%
280	Pituitary Apoplexy	11.8%
281	neurofibroma	11.7%
282	Tardive Dyskinesia	11.7%
283	Brain Infarction	11.6%
284	Hand-Arm Vibration Syndrome	11.6%
285	Infarction, Middle Cerebral Artery	11.6%
286	Infarction, Anterior Cerebral Artery	11.6%
287	Infarction, Posterior Cerebral Artery	11.6%
288	Ophthalmoplegia	11.5%
289	External Ophthalmoplegia	11.5%
290	Amyloid Neuropathies, Familial	11.4%
291	Fibromyalgia	11.4%
292	Central Nervous System Bacterial Infections	11.4%
293	Medial Tibial Stress Syndrome	11.4%
294	Amnesia, Transient Global	11.3%
295	Jet Lag Syndrome	11.3%
296	Mitochondrial Myopathies	11.2%
297	Eosinophilia-Myalgia Syndrome	11.2%
298	Diffuse Axonal Injury	10.8%
299	Brain Stem Neoplasms	10.8%
300	Alstrom Syndrome	10.8%
301	Alice in Wonderland Syndrome	10.6%
302	Brain Concussion	10.5%
303	Pupil Disorders	10.5%
304	Neurobehavioral Manifestations	10.5%
305	Cerebral Infarction	10.4%
306	Brain Stem Infarctions	10.4%
307	Pituitary Diseases	10.3%
308	Coma, Post-Head Injury	10.3%
309	Polyradiculopathy	10.3%
310	Post-Traumatic Headache	10.3%
311	Tension Headache	10.3%
312	Epilepsy, Complex Partial	10.3%
313	Migraine Disorders	10.3%
314	Abdominal Migraine	10.3%
315	Status Migrainosus	10.3%
316	Cervicogenic Headache	10.3%
317	Subarachnoid Hemorrhage, Traumatic	10.2%
318	Carotid Artery, Internal, Dissection	10.2%
319	Spinal Cord Diseases	10.2%
320	Vocal Cord Paralysis	10.1%
321	Uveomeningoencephalitic Syndrome	10.1%
322	MELAS Syndrome	10.1%
323	Thoracic Outlet Syndrome	10.1%
324	Vertebral Artery Dissection	10.1%
325	Sturge-Weber Syndrome	10.1%
326	Vertigo	10.1%
327	Alcohol-Induced Disorders, Nervous System	10.1%
328	Carotid Artery Diseases	9.9%
329	Brain Ischemia	9.9%
330	Cerebrovascular accident	9.9%
331	Polymyositis	9.9%
332	Kluver-Bucy Syndrome	9.9%
333	Vasospasm, Intracranial	9.9%
334	Intracranial Arterial Diseases	9.9%
335	Cerebrospinal Fluid Otorrhea	9.9%
336	Cerebrospinal Fluid Rhinorrhea	9.9%
337	Gait Ataxia	9.8%
338	Tuberculosis, Central Nervous System	9.8%
339	West Nile Fever	9.8%
340	Multiple Sclerosis, Chronic Progressive	9.8%
341	Multiple Sclerosis, Relapsing-Remitting	9.8%
342	Lateral Medullary Syndrome	9.8%
343	Choroid Plexus Papilloma	9.7%
344	Moyamoya Disease	9.7%
345	Familial Periodic Paralysis	9.5%
346	Adrenoleukodystrophy	9.5%
347	Brain Contusion	9.3%
348	Cluster Headache	9.2%
349	Migraine with Aura	9.2%
350	Familial Hemiplegic Migraine	9.2%
351	Chronic Paroxysmal Hemicrania	9.2%
352	SUNCT Syndrome	9.2%
353	Paroxysmal Hemicrania	9.2%
354	Voice Disorders	8.8%
355	Voice Disturbance	8.8%
356	Alcohol Withdrawal Seizures	8.8%
357	Auditory Perceptual Disorders	8.7%
358	Smith-Magenis syndrome	8.7%
359	Akathisia	8.6%
360	Restlessness	8.6%
361	Psychomotor Agitation	8.6%
362	Dural Arteriovenous Fistula	8.6%
363	Optic Nerve Glioma	8.6%
364	Muscular Dystrophy	8.4%
365	Orbital Myositis	8.4%
366	Empty Sella Syndrome	8.4%
367	Hyperpituitarism	8.4%
368	Hypopituitarism	8.4%
369	Hypophysitis	8.4%
370	Reye Syndrome	8.3%
371	Neuroaspergillosis	8.3%
372	Pyomyositis	8.3%
373	Myalgia	8.3%
374	Intracranial Embolism and Thrombosis	8.2%
375	Hepatic Encephalopathy	8.2%
376	Cerebral Arterial Diseases	8.2%
377	Neuronal Ceroid-Lipofuscinoses	8.2%
378	Vertebrobasilar Insufficiency	8.2%
379	Basilar Artery Stenosis	8.2%
380	Vertebral Artery Stenosis	8.2%
381	Intracranial Hemorrhage, Hypertensive	8.2%
382	Transient Cerebral Ischemia	8.2%
383	Optic Atrophy	8.1%
384	Optic Neuritis	8.1%
385	Papilledema	8.1%
386	Strabismus	8.1%
387	Tolosa-Hunt Syndrome	8.1%
388	Arsenic Poisoning	8.1%
389	Giant Cell Arteritis	8%
390	Temporal Arteritis	8%
391	Facial Injuries	8%
392	Facial Neuralgia	8%
393	Sleep Talking	8%
394	Manganese Poisoning	8%
395	Sleep Disorders, Intrinsic	8%
396	Orthostatic intolerance	8%
397	Gait Apraxia	8%
398	Anosmia	7.9%
399	Ataxia	7.9%
400	Athetosis	7.9%
401	Catalepsy	7.9%
402	Dystonia	7.9%
403	Hemiplegia	7.9%
404	Locked-In Syndrome	7.9%
405	Meningeal Neoplasms	7.9%
406	Meningomyelocele	7.9%
407	Muscle Hypertonia	7.9%
408	Muscle hypotonia	7.9%
409	Myoclonus	7.9%
410	Myotonia	7.9%
411	Paraplegia	7.9%
412	Pseudobulbar Palsy	7.9%
413	Quadriplegia	7.9%
414	Spasm	7.9%
415	Spastic Paraplegia	7.9%
416	Status Epilepticus	7.9%
417	Taste Disorders	7.9%
418	Tremor	7.9%
419	Spina Bifida	7.9%
420	Monoplegia	7.9%
421	Hypokinesia	7.9%
422	Paraparesis	7.9%
423	Bradykinesia	7.9%
424	Waxy flexibility	7.9%
425	Action Tremor	7.9%
426	Resting Tremor	7.9%
427	Dysosmia	7.9%
428	Quadriparesis	7.9%
429	Mercury Poisoning, Nervous System	7.9%
430	Olfaction Disorders	7.9%
431	Myokymia	7.9%
432	Lead Poisoning, Nervous System	7.9%
433	Vestibular Neuronitis	7.9%
434	Somatosensory Disorders	7.9%
435	Hyperkinesia	7.9%
436	Intention tremor	7.9%
437	Neurofibrosarcoma	7.6%
438	Reflex, Abnormal	7.5%
439	Hyporeflexia	7.5%
440	Hyperreflexia	7.5%
441	Postural Orthostatic Tachycardia Syndrome	7.4%
442	Hyperprolactinemia	7.4%
443	Pseudorabies	7.4%
444	Cockayne Syndrome	7.4%
445	Optic Atrophy, Hereditary, Leber	7.4%
446	Subclavian Steal Syndrome	7.3%
447	Pick Disease of the Brain	7.3%
448	Hematoma, Subdural	7.3%
449	Hematoma, Epidural, Cranial	7.3%
450	Brain Diseases, Metabolic, Inborn	7.1%
451	POEMS Syndrome	7.1%
452	Neurosyphilis	7%
453	Hypokalemic periodic paralysis	7%
454	Toxoplasmosis, Congenital	6.9%
455	Malaria, Cerebral	6.9%
456	Vision Disorders	6.9%
457	Metamorphopsia	6.9%
458	Visual Impairment	6.9%
459	Kearns-Sayre syndrome	6.9%
460	Carotid Stenosis	6.8%
461	Intracranial Aneurysm	6.8%
462	Welander Distal Myopathy	6.8%
463	Neurocysticercosis	6.8%
464	Optic Neuropathy, Ischemic	6.8%
465	Anterior Ischemic Optic Neuropathy	6.8%
466	Intracranial Arteriosclerosis	6.8%
467	Cerebral Atherosclerosis	6.8%
468	Subarachnoid Hemorrhage	6.8%
469	Cerebral Arteriosclerosis	6.8%
470	Cerebral Hemorrhage	6.8%
471	Cerebral Thrombosis	6.8%
472	Intracranial Embolism	6.8%
473	Intracranial Thrombosis	6.8%
474	Facial Hemiatrophy	6.7%
475	Melkersson-Rosenthal Syndrome	6.7%
476	Anisocoria	6.7%
477	Confusion	6.7%
478	Facial paralysis	6.7%
479	Lethargy	6.7%
480	Memory Disorders	6.7%
481	Muscle Cramp	6.7%
482	Perceptual Disorders	6.7%
483	Psychomotor Disorders	6.7%
484	Tonic Pupil	6.7%
485	Anhedonia	6.7%
486	Disorientation	6.7%
487	Facial Paresis	6.7%
488	Memory Loss	6.7%
489	Hemisensory Neglect	6.7%
490	Dysacusis	6.7%
491	Classical Lissencephalies and Subcortical Band Heterotopias	6.7%
492	Sleep Bruxism	6.7%
493	Anencephaly	6.6%
494	Meningocele	6.6%
495	Muscular Atrophy	6.6%
496	Respiratory Paralysis	6.6%
497	Encephalocele	6.6%
498	Tetany	6.6%
499	Acoustic Neuroma	6.5%
500	Hematoma, Subdural, Intracranial	6.5%
501	Hematoma, Subdural, Chronic	6.5%
502	Hematoma, Subdural, Acute	6.5%
503	Waterhouse-Friderichsen Syndrome	6.4%
504	Acromegaly	6.2%
505	Wernicke Encephalopathy	6.2%
506	AIDS Dementia Complex	6.2%
507	Lyme Neuroborreliosis	6.1%
508	Cerebral Amyloid Angiopathy	6.1%
509	Alexia	6.1%
510	Dyslexia	6.1%
511	Sinus Thrombosis, Intracranial	6.1%
512	Dermatomyositis	6%
513	Esotropia	6%
514	Exotropia	6%
515	Hypotension, Orthostatic	6%
516	Sleep Apnea Syndromes	6%
517	Post-Exercise Hypotension	6%
518	Disorders of Excessive Somnolence	5.9%
519	Sleep Initiation and Maintenance Disorders	5.9%
520	Night Terrors	5.9%
521	Somnambulism	5.9%
522	Trigeminal Nerve Disorder	5.9%
523	Transient Insomnia	5.9%
524	Sleep Paralysis	5.9%
525	Chronic Insomnia	5.9%
526	REM Sleep Behavior Disorder	5.9%
527	Hypersomnia	5.9%
528	Dermal Sinus	5.9%
529	Dysgeusia	5.9%
530	Formication	5.9%
531	Hyperalgesia	5.9%
532	Hyperesthesia	5.9%
533	Hypesthesia	5.9%
534	Language Disorders	5.9%
535	Numbness	5.9%
536	Paresthesia	5.9%
537	Paraparesis, Spastic	5.9%
538	Spina Bifida Cystica	5.9%
539	Trismus	5.9%
540	Spina Bifida Occulta	5.9%
541	Epilepsia Partialis Continua	5.9%
542	Hypogeusia	5.9%
543	Meningeal Carcinomatosis	5.9%
544	Brown-Sequard Syndrome	5.9%
545	Lissencephaly	5.9%
546	Polymicrogyria	5.9%
547	Pachygyria	5.9%
548	Schizencephaly	5.9%
549	Lockjaw	5.9%
550	Allodynia	5.9%
551	Lead Poisoning, Nervous System, Childhood	5.9%
552	Lead Poisoning, Nervous System, Adult	5.9%
553	Periventricular Nodular Heterotopia	5.9%
554	Ageusia	5.9%
555	Muscular Dystrophy, Duchenne	5.9%
556	Duane Retraction Syndrome	5.8%
557	Carotid Artery Thrombosis	5.8%
558	Consciousness Disorders	5.8%
559	Mental Retardation	5.8%
560	Muscle Weakness	5.8%
561	Depressed Level of Consciousness	5.8%
562	Mental deficiency	5.8%
563	Intellectual Disability	5.8%
564	Mobius Syndrome	5.8%
565	Bell Palsy	5.8%
566	Catatonia	5.7%
567	Herpes Zoster Oticus	5.7%
568	Cavernous Sinus Thrombosis	5.7%
569	Sagittal Sinus Thrombosis	5.7%
570	Aphonia	5.7%
571	Sleep Deprivation	5.7%
572	Dysphonia	5.7%
573	Kernicterus	5.6%
574	Eye Injuries	5.1%
575	Congenital nystagmus	5%
576	Menkes Kinky Hair Syndrome	5%
577	Diplopia	5%
578	Muscle Rigidity	5%
579	Muscle Spasticity	5%
580	Scotoma	5%
581	Photophobia	5%
582	Cogwheel Rigidity	5%
583	Hemifacial Spasm	5%
584	Amaurosis	5%
585	Blindness	5%
586	Nuchal Rigidity	5%
587	Fabry Disease	4.9%
588	Nelson Syndrome	4.9%
589	Agnosia	4.9%
590	Apraxias	4.9%
591	Hallucinations	4.9%
592	Hemianopsia	4.9%
593	Hyperacusis	4.9%
594	Tinnitus	4.9%
595	Visual Agnosia	4.9%
596	Anosognosia	4.9%
597	Wernicke-Korsakoff Syndrome	4.9%
598	Phonophobia	4.9%
599	Hearing Loss	4.9%
600	Sleep Apnea, Obstructive	4.9%
601	Sleep Apnea, Central	4.9%
602	Sarcopenia	4.9%
603	Narcolepsy	4.9%
604	Trigeminal Neuralgia	4.9%
605	Kleine-Levin Syndrome	4.9%
606	Agraphia	4.9%
607	Anomia	4.9%
608	Cluttering	4.9%
609	Language Development Disorders	4.9%
610	Speech Disorders	4.9%
611	Syncope	4.9%
612	Stupor	4.9%
613	Dysgraphia	4.9%
614	Presyncope	4.9%
615	Dyslalia	4.9%
616	Prolactinoma	4.6%
617	Growth Hormone-Secreting Pituitary Adenoma	4.6%
618	Galactosemias	4.5%
619	Urea Cycle Disorders, Inborn	4.5%
620	Tyrosinemias	4.5%
621	Aicardi's syndrome	4.5%
622	Hoarseness	4.5%
623	Alcohol Withdrawal Delirium	4.4%
624	Cataplexy	4.4%
625	Aphasia	4.4%
626	Articulation Disorders	4.4%
627	Echolalia	4.4%
628	Stuttering	4.4%
629	Dysphasia	4.4%
630	Amnesia	4.3%
631	Delirium	4.3%
632	Dissociative Amnesia	4.3%
633	Color blindness	4.3%
634	Global Amnesia	4.3%
635	Cri-du-Chat Syndrome	4.3%
636	Down Syndrome	4.3%
637	Trisomy 21	4.3%
638	Meningioma	4.2%
639	Williams Syndrome	4.2%
640	Microcephaly	4.2%
641	Macrocephaly	4.2%
642	Porencephaly	4.2%
643	Dysarthria	4.1%
644	Eye Burns	4.1%
645	Amaurosis Fugax	4.1%
646	Blindness, Cortical	4.1%
647	Dyscalculia	4.1%
648	Homocystinuria	4.1%
649	Rett Syndrome	4.1%
650	Deafness	4.1%
651	Hearing Loss, Sudden	4.1%
652	Gerstmann Syndrome	4.1%
653	Hearing Loss, Bilateral	4.1%
654	Hearing Loss, High-Frequency	4.1%
655	Hearing Loss, Mixed Conductive-Sensorineural	4.1%
656	Prosopagnosia	4.1%
657	Apraxia, Ideomotor	4.1%
658	Charles Bonnet Syndrome	4.1%
659	Hearing Loss, Unilateral	4.1%
660	Complete Hearing Loss	4.1%
661	Alien Hand Syndrome	4.1%
662	Deaf Mutism	4.1%
663	Leigh Disease	4.1%
664	Holoprosencephaly	4%
665	Prader-Willi Syndrome	3.7%
666	Mutism	3.7%
667	Selective Mutism	3.7%
668	Phantom pain	3.7%
669	Phantom Limb Pain	3.7%
670	Carbamoyl-Phosphate Synthase I Deficiency Disease	3.6%
671	Corneal Scar	3.6%
672	Retrograde amnesia	3.5%
673	Amnesia, Anterograde	3.5%
674	Alexia, Pure	3.5%
675	Glycogen storage disease type II	3.3%
676	Corneal Perforation	3.2%
677	Zellweger Syndrome	3.2%
678	Fragile X Syndrome	3.1%
679	Rubinstein-Taybi Syndrome	3%
680	Gaucher Disease	2.8%
681	Tay-Sachs Disease	2.7%
682	Niemann-Pick Disease, Type C	2.5%
683	Mucopolysaccharidosis II	2.2%

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