MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hyperinsulinism

(UMLS:C0020459)

Definition:: A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin (INSULIN ANTIBODIES); defective insulin receptor (INSULIN RESISTANCE); or overuse of exogenous insulin or HYPOGLYCEMIC AGENTS.
UMLS ID:: C0020459
MeSH ID:: D006946

Classification:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.394.968

Synonym(s)

Hyperinsulinism

Elevated insulin level

HYPERINSULINEMIA

Hyperinsulinaemia

Hyperinsulinemia

Hyperinsulinism syndrome

Hyperinsulinism, NOS

high insulin

hyperinsulinaemia

10.

hyperinsulinemia

11.

hyperinsulinism

12.

hyperinsulism

13.

increased insulin

14.

increasing insulin

15.

insulin high

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Olanzapine	FAERS: 12	11927762	CTD US FAERS
2	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 4		US FAERS
3	Fluticasone	FAERS: 3		US FAERS
4	Glyburide	FAERS: 2		US FAERS
5	fluticasone furoate	FAERS: 2		US FAERS
6	Diazoxide	FAERS: 1	2040926 3970573 17937066	CTD US FAERS
7	Exenatide	FAERS: 1		US FAERS
8	Fluoxetine	FAERS: 1		US FAERS
9	Fluticasone-Salmeterol Drug Combination	FAERS: 1		US FAERS
10	Insulin Glargine	FAERS: 1		US FAERS
11	Melphalan	FAERS: 1		US FAERS
12	sapropterin	FAERS: 1		US FAERS
13	4b,5,9b,10-tetrahydroindeno(1,2-b)indole		18823964	CTD
14	Albuterol		8098220	CTD
15	Allopurinol		19605544 24491314	CTD
16	Aripiprazole			SIDER
17	Ascorbic Acid		31005848	CTD
18	Bezafibrate		21549692	CTD
19	Chromium		18806091	CTD
20	Cilazapril		8563700	CTD
21	Copper		26033743	CTD
22	Danazol			SIDER
23	Dexamethasone		View details 15824971 19158320 21123945 28292967	CTD
24	Dichlorodiphenyl Dichloroethylene		25541407 28867213	CTD
25	Estrone		3519326	CTD
26	Fructose		View details 7498971 10703878 12661920 14757778 15752949 16234313 18360027 18563319 18948349 19008412 19605544 19845545 21708140 23533474 24491314 25169908 25679220 27287418 31005848 31233715	CTD
27	GW 4064		23371517	CTD
28	Gliclazide		18380531	CTD
29	Glutamine		31233715	CTD
30	Losartan		7498971	CTD
31	Malathion		25180440	CTD
32	Metformin		8781288 18377884	CTD
33	Naltrexone		16901484	CTD
34	Nateglinide		11074662	CTD
35	Niacin			SIDER
36	Octopamine		15000448	CTD
37	Paliperidone Palmitate			SIDER
38	Pioglitazone		18448808 25679220 25796170	CTD
39	Quercetin		View details 18551111 19605544 21462320 24491314 30372826	CTD
40	Resveratrol		View details 18426865 19819963 22309033 25849131	CTD
41	Risperidone		11927762	CTD SIDER
42	Ritodrine		3883263	CTD
43	Rosiglitazone		17697064 18948349 23954466	CTD
44	Rutin		19605544	CTD
45	Sildenafil Citrate		19845545	CTD
46	Sotalol			SIDER
47	Streptozocin		18377884 29988851	CTD
48	Sucrose		18806091	CTD
49	Sulpiride		29551354	CTD
50	Testosterone Propionate		23457541	CTD
51	Thioctic Acid		22664981	CTD
52	Trimethoprim, Sulfamethoxazole Drug Combination		14714756	CTD
53	Troglitazone		View details 8786734 9389757 9502777 11889176 11909685 12661920	CTD
54	Valproic Acid		19184102 29229235	CTD
55	aromadedrin		30372826	CTD
56	benazepril		9725782	CTD
57	bisphenol A		View details 27145005 27502578 28153594 28483554	CTD
58	chrysin		25169908	CTD
59	cyanoginosin LR		29777831	CTD
60	esculetin		28946194	CTD
61	ferulic acid		27287418	CTD
62	fumosorinone		25796170	CTD
63	galangin		21708140	CTD
64	gastrodin		26634892	CTD
65	geraniol		31005848	CTD
66	kaempferol		30372826	CTD
67	mangiferin		9881663 11315760	CTD
68	monascin		23954466	CTD
69	naringenin		23782265 30372826	CTD
70	neomangiferin		9881663	CTD
71	phoxim		30090575	CTD
72	sodium arsenite		16111841	CTD
73	taxifolin		30372826	CTD
74	tributyltin		28161095	CTD
75	zopolrestat		27287418	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Hyperglycemia	46.7%
2	Hypoglycemia	46.7%
3	Diabetes Mellitus	33.3%
4	Acid-Base Imbalance	31%
5	Calcium Metabolism Disorders	31%
6	Iron Metabolism Disorders	31%
7	Phosphorus Metabolism Disorders	31%
8	Water-Electrolyte Imbalance	31%
9	Lipid Metabolism Disorders	31%
10	Mitochondrial Diseases	31%
11	Wasting Syndrome	27.9%
12	Hypercalcemia	26.7%
13	Hypocalcemia	26.7%
14	Milk-Alkali Syndrome	26.7%
15	Diabetic Ketoacidosis	23.3%
16	Glycosuria	23.1%
17	Osteopenia	20.9%
18	Brain Diseases, Metabolic	20.5%
19	Acidosis	20%
20	Alkalosis	20%
21	Amyloidosis	20%
22	Calcinosis	20%
23	Hyperkalemia	20%
24	Hypernatremia	20%
25	Hypokalemia	20%
26	Hyponatremia	20%
27	Lipodystrophy	20%
28	Xanthomatosis	20%
29	Hypophosphatemia	20%
30	Metabolic acidosis	20%
31	Dyslipidemias	20%
32	Iron Overload	20%
33	Xanthoma	20%
34	Nutrition Disorders	18.5%
35	Pseudohypoparathyroidism	18.1%
36	Gestational Diabetes	17.9%
37	Latent Autoimmune Diabetes in Adults	17.9%
38	Diabetes Mellitus, Experimental	17.6%
39	Rickets	17.3%
40	Brain Diseases, Metabolic, Inborn	15.9%
41	Leigh Disease	15.2%
42	Hyperhomocysteinemia	15.1%
43	Acidosis, Lactic	14.8%
44	Calciphylaxis	14.8%
45	Hemosiderosis	14.8%
46	Ketosis	14.8%
47	Ketonuria	14.8%
48	Ketoacidosis	14.8%
49	Ketonemia	14.8%
50	Vascular calcification	14.8%
51	Hypolipoproteinemias	14.6%
52	Hyperlipoproteinemia Type IV	14.5%
53	Hyperlipoproteinemia Type V	14.5%
54	Congenital Hyperinsulinism	14.2%
55	Carbamoyl-Phosphate Synthase I Deficiency Disease	13.8%
56	Lactose Intolerance	13.7%
57	Dehydration	13.6%
58	Lipomatosis	13.6%
59	Water Intoxication	13.6%
60	Werner Syndrome	13.6%
61	Hyperlipidemia, Familial Combined	13.4%
62	Achlorhydria	13.3%
63	Amino Acid Metabolism, Inborn Errors	13.3%
64	Bloom Syndrome	13.3%
65	Carbohydrate Metabolism, Inborn Errors	13.3%
66	Metal Metabolism, Inborn Errors	13.3%
67	Osteoporosis	13.3%
68	Progeria	13.3%
69	Lysosomal Storage Diseases	13.3%
70	Bone Demineralization, Pathologic	13.3%
71	Cytochrome-c Oxidase Deficiency	13.3%
72	Peroxisomal Disorders	13.3%
73	Post-Traumatic Osteoporosis	13.3%
74	Celiac Disease	13.2%
75	Sprue, Tropical	13.2%
76	Steatorrhea	13.2%
77	Sprue	13.2%
78	Osteomalacia	13%
79	Hyperlipoproteinemia Type III	12.7%
80	Smith-Lemli-Opitz Syndrome	12.6%
81	Galactosemias	12.5%
82	Urea Cycle Disorders, Inborn	12.5%
83	Tyrosinemias	12.5%
84	Hypercholesterolemia	12.2%
85	Hyperlipoproteinemias	12.2%
86	Hypertriglyceridemia	12.2%
87	Glycosuria, Renal	12.1%
88	Hypoalphalipoproteinemias	12%
89	Familial Hypophosphatemic Rickets	11.5%
90	Mitochondrial Encephalomyopathies	11.5%
91	Nesidioblastosis	11.4%
92	Gaucher Disease	10.9%
93	Hyperphosphaturia	10.9%
94	Glycogen storage disease type II	10.6%
95	Homocystinuria	10.4%
96	Child Nutrition Disorders	10.3%
97	Hypervitaminosis A	10.3%
98	Infant Nutrition Disorders	10.3%
99	Malnutrition	10.3%
100	Mitochondrial Myopathies	10.2%
101	Myelinolysis, Central Pontine	10.1%
102	Reye Syndrome	9.9%
103	Acidosis, Respiratory	9.9%
104	Adiposis Dolorosa	9.9%
105	Alkalosis, Respiratory	9.9%
106	Hepatic Encephalopathy	9.8%
107	Tay-Sachs Disease	9.8%
108	Alkaptonuria	9.8%
109	Glycogen Storage Disease	9.8%
110	Hypophosphatasia	9.8%
111	Osteoporosis, Postmenopausal	9.8%
112	Propionic acidemia	9.8%
113	Dihydropyrimidine Dehydrogenase Deficiency	9.8%
114	Cystinosis	9.8%
115	Amyloid Neuropathies, Familial	9.8%
116	Renal tubular acidosis	9.7%
117	Niemann-Pick Disease, Type C	9.3%
118	Neuronal Ceroid-Lipofuscinoses	9%
119	HIV Wasting Syndrome	8.8%
120	Fabry Disease	8.5%
121	HIV-Associated Lipodystrophy Syndrome	8.4%
122	MELAS Syndrome	8.2%
123	Renal Osteodystrophy	8.2%
124	Renal rickets	8.2%
125	Porphyrias, Hepatic	8.1%
126	Glycogen Storage Disease Type I	8.1%
127	Glycogen Storage Disease Type V	8.1%
128	Zellweger Syndrome	8%
129	Mucopolysaccharidosis III	8%
130	Adrenoleukodystrophy	8%
131	Necrobiosis Lipoidica Diabeticorum	7.9%
132	Menkes Kinky Hair Syndrome	7.9%
133	Fanconi Anemia	7.8%
134	Wernicke Encephalopathy	7.7%
135	Hepatolenticular Degeneration	7.4%
136	Nephrocalcinosis	7.4%
137	Tetany	7.4%
138	Refsum Disease	7.3%
139	Cerebral Amyloid Angiopathy	7.2%
140	Deficiency Diseases	6.7%
141	Starvation	6.7%
142	Refeeding Syndrome	6.7%
143	Friedreich Ataxia	6.5%
144	Familial Periodic Paralysis	6%
145	Primary amyloidosis	6%
146	Variegate Porphyria	5.9%
147	Acute intermittent porphyria	5.9%
148	Porphyria Cutanea Tarda	5.9%
149	Renal Aminoacidurias	5.8%
150	Fanconi Syndrome	5.8%
151	Pseudohypoaldosteronism	5.8%
152	Liddle Syndrome	5.8%
153	Kernicterus	5.7%
154	Kearns-Sayre syndrome	5.7%
155	Cockayne Syndrome	5.7%
156	Canavan Disease	5.4%
157	Alexander Disease	5.4%
158	Sjogren-Larsson Syndrome	5.4%
159	Mucopolysaccharidosis II	5.3%
160	Ataxia Telangiectasia	5.1%
161	Gout	5%
162	Amyotrophic Lateral Sclerosis	5%
163	Kwashiorkor	4.9%
164	Magnesium Deficiency	4.9%
165	Potassium Deficiency	4.9%
166	Protein Deficiency	4.9%
167	Avitaminosis	4.9%
168	Optic Atrophy, Hereditary, Leber	4.9%
169	Antley-Bixler Syndrome Phenotype	4.9%
170	Hypokalemic periodic paralysis	4.9%
171	Frontotemporal dementia	4.8%
172	Cystinuria	4.8%
173	Xeroderma Pigmentosum	4.5%
174	CREST Syndrome	4.2%
175	Ascorbic Acid Deficiency	4.1%
176	Vitamin A Deficiency	4.1%
177	Vitamin D Deficiency	4.1%
178	Vitamin E Deficiency	4.1%
179	Marasmus	4.1%
180	Arthritis, Gouty	4.1%
181	Albinism	3.7%
182	Folic Acid Deficiency	3.6%
183	Pellagra	3.6%
184	Thiamine Deficiency	3.6%
185	Vitamin B 12 Deficiency	3.6%
186	Vitamin B 6 Deficiency	3.6%
187	Pyridoxine Deficiency	3.6%
188	Beriberi	3.4%
189	Ichthyosis, X-Linked	3%
190	Obesity	2.6%
191	Obesity, Abdominal	2.4%
192	Anemia, Pernicious	2.3%
193	Vitamin K Deficiency	2.1%
194	Pediatric Obesity	1.9%
195	Scurvy	1.8%
196	Prader-Willi Syndrome	1.6%
197	Subacute Combined Degeneration	1.2%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234