MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hyperlipidemia, Familial Combined

(UMLS:C0020474)

Definition:: A type of familial lipid metabolism disorder characterized by a variable pattern of elevated plasma CHOLESTEROL and/or TRIGLYCERIDES. Multiple genes on different chromosomes may be involved, such as the major late transcription factor (UPSTREAM STIMULATORY FACTORS) on CHROMOSOME 1.
UMLS ID:: C0020474
MeSH ID:: D006950

Classification 1:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.565.398.450

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.584.500.500.438|C18.452.648.398.450

Synonym(s)

Hyperlipidemia, Familial Combined

FCHL (familial combined hyperlipidemia)

FCHL - Familial combined hyperlipidaemia

FCHL - Familial combined hyperlipidemia

Familial Combined Hyperlipidemia

Familial combined hyperlipidaemia

Familial combined hyperlipidemia

Familial hyperlipoproteinaemia type IIb

Familial hyperlipoproteinemia type IIb

10.

Familial multiple lipoprotein-type hyperlipidaemia

11.

Familial multiple lipoprotein-type hyperlipidemia

12.

Fredrickson type IIb hyperlipoproteinaemia

13.

Fredrickson type IIb hyperlipoproteinemia

14.

HYPERLIPIDEMIA, FAMILIAL COMBINED, 3

15.

Hyperapobetalipoproteinaemia

16.

Hyperapobetalipoproteinemia

17.

Hyperlipidemia Type IIb

18.

Hyperlipoproteinemia Type IIb

19.

MIXED HYPERLIPIDEMIA

20.

Multiple-type hyperlipidaemia

21.

Multiple-type hyperlipidemia

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Bezafibrate	3760707	CTD
2	Ezetimibe	20152243	CTD
3	Fenofibrate	3760707	CTD
4	Niacin	15539964 20152243	CTD
5	Rosuvastatin Calcium	15539964	CTD
6	Simvastatin	20152243	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Hyperlipoproteinemia Type IV	54.1%
2	Hyperlipoproteinemia Type V	54.1%
3	Hypolipoproteinemias	49.9%
4	Hyperlipoproteinemia Type III	48.9%
5	Smith-Lemli-Opitz Syndrome	46.1%
6	Hypoalphalipoproteinemias	35.9%
7	Amino Acid Metabolism, Inborn Errors	32.2%
8	Carbohydrate Metabolism, Inborn Errors	32.2%
9	Metal Metabolism, Inborn Errors	32.2%
10	Progeria	32.2%
11	Lysosomal Storage Diseases	32.2%
12	Peroxisomal Disorders	32.2%
13	Brain Diseases, Metabolic, Inborn	30.8%
14	Neuronal Ceroid-Lipofuscinoses	29.7%
15	Hypercholesterolemia	28.4%
16	Hyperlipoproteinemias	28.4%
17	Hypertriglyceridemia	28.4%
18	Galactosemias	27%
19	Urea Cycle Disorders, Inborn	27%
20	Tyrosinemias	27%
21	Leigh Disease	26.8%
22	Pseudohypoparathyroidism	26.7%
23	Gaucher Disease	25.5%
24	Wasting Syndrome	25.4%
25	Cytochrome-c Oxidase Deficiency	24.4%
26	Hyperphosphaturia	24.3%
27	Hyperhomocysteinemia	23.5%
28	Acid-Base Imbalance	23.5%
29	Calcium Metabolism Disorders	23.5%
30	Iron Metabolism Disorders	23.5%
31	Phosphorus Metabolism Disorders	23.5%
32	Water-Electrolyte Imbalance	23.5%
33	Mitochondrial Diseases	23.5%
34	Glucose Metabolism Disorders	23.5%
35	Lipodystrophy	23.4%
36	Carbamoyl-Phosphate Synthase I Deficiency Disease	23%
37	Glycogen storage disease type II	23%
38	Lactose Intolerance	22.6%
39	Fabry Disease	22.4%
40	Menkes Kinky Hair Syndrome	21.7%
41	Homocystinuria	21.7%
42	Hypercalcemia	21.5%
43	Hypocalcemia	21.5%
44	Milk-Alkali Syndrome	21.5%
45	Xanthomatosis	21.5%
46	Xanthoma	21.5%
47	Sjogren-Larsson Syndrome	21.2%
48	Alkaptonuria	20.9%
49	Glycogen Storage Disease	20.9%
50	Hypophosphatasia	20.9%
51	Propionic acidemia	20.9%
52	Dihydropyrimidine Dehydrogenase Deficiency	20.9%
53	Cystinosis	20.9%
54	Tay-Sachs Disease	20.8%
55	Werner Syndrome	20.8%
56	Niemann-Pick Disease, Type C	20.7%
57	Adrenoleukodystrophy	20.1%
58	Hepatolenticular Degeneration	19.7%
59	Zellweger Syndrome	19.7%
60	Refsum Disease	19.2%
61	Mucopolysaccharidosis III	19.2%
62	Osteopenia	19.1%
63	Brain Diseases, Metabolic	18.8%
64	Amyloid Neuropathies, Familial	18.3%
65	Lipomatosis	17.5%
66	Mucopolysaccharidosis II	17.4%
67	Renal tubular acidosis	17.3%
68	Familial Hypophosphatemic Rickets	16.9%
69	Albinism	16.6%
70	Rickets	16.3%
71	Glycogen Storage Disease Type I	15.3%
72	Glycogen Storage Disease Type V	15.3%
73	Familial Periodic Paralysis	15.2%
74	Ichthyosis, X-Linked	15.1%
75	Renal Aminoacidurias	14.9%
76	Fanconi Syndrome	14.9%
77	Pseudohypoaldosteronism	14.9%
78	Liddle Syndrome	14.9%
79	Nutrition Disorders	14.9%
80	Antley-Bixler Syndrome Phenotype	13.9%
81	Glycosuria, Renal	13.8%
82	Cockayne Syndrome	13.7%
83	MELAS Syndrome	13.5%
84	Acidosis	13.4%
85	Alkalosis	13.4%
86	Amyloidosis	13.4%
87	Calcinosis	13.4%
88	Hyperglycemia	13.4%
89	Hyperinsulinism	13.4%
90	Hyperkalemia	13.4%
91	Hypernatremia	13.4%
92	Hypoglycemia	13.4%
93	Hypokalemia	13.4%
94	Hyponatremia	13.4%
95	Hypophosphatemia	13.4%
96	Metabolic acidosis	13.4%
97	Iron Overload	13.4%
98	Gout	13.3%
99	Bloom Syndrome	12.7%
100	Lipid Metabolism Disorders	12.3%
101	Congenital Hyperinsulinism	12.3%
102	Porphyrias, Hepatic	12.1%
103	Canavan Disease	11.9%
104	Alexander Disease	11.9%
105	Fanconi Anemia	11.8%
106	Diabetes Mellitus	11.2%
107	Hypokalemic periodic paralysis	11%
108	Mitochondrial Encephalomyopathies	11%
109	Cystinuria	10.9%
110	Dehydration	10.9%
111	Water Intoxication	10.9%
112	Achlorhydria	10.7%
113	Osteoporosis	10.7%
114	Bone Demineralization, Pathologic	10.7%
115	Post-Traumatic Osteoporosis	10.7%
116	Adiposis Dolorosa	10.7%
117	Celiac Disease	10.7%
118	Sprue, Tropical	10.7%
119	Steatorrhea	10.7%
120	Sprue	10.7%
121	Ataxia Telangiectasia	10.5%
122	Osteomalacia	10.4%
123	Neoplastic Syndromes, Hereditary	10.3%
124	CHARGE Syndrome	9.9%
125	Multiple Epiphyseal Dysplasia	9.9%
126	Osteochondrodysplasias	9.9%
127	Pelger-Huet Anomaly	9.9%
128	Myasthenic Syndromes, Congenital	9.9%
129	Cystic Fibrosis	9.7%
130	Diabetic Ketoacidosis	9.7%
131	HIV-Associated Lipodystrophy Syndrome	9.7%
132	Arthritis, Gouty	9.7%
133	Aicardi's syndrome	9.2%
134	Optic Atrophy, Hereditary, Leber	9.2%
135	Mitochondrial Myopathies	9.1%
136	Friedreich Ataxia	9.1%
137	Myelinolysis, Central Pontine	9%
138	Glycosuria	8.9%
139	Reye Syndrome	8.9%
140	HIV Wasting Syndrome	8.9%
141	Hepatic Encephalopathy	8.9%
142	Xeroderma Pigmentosum	8.6%
143	Nail-Patella Syndrome	8.6%
144	Dwarfism	8.5%
145	Acidosis, Lactic	8.4%
146	Calciphylaxis	8.4%
147	Hemosiderosis	8.4%
148	Ketosis	8.4%
149	Ketonuria	8.4%
150	Ketoacidosis	8.4%
151	Ketonemia	8.4%
152	Vascular calcification	8.4%
153	Anemia, Sickle Cell	8.4%
154	Thalassemia	8.4%
155	Muscular Dystrophy, Duchenne	8.3%
156	Nesidioblastosis	8.3%
157	Muscular Dystrophy	8.2%
158	Osteogenesis Imperfecta	8.2%
159	Beckwith-Wiedemann Syndrome	8.2%
160	Wolf-Hirschhorn Syndrome	8.2%
161	Fragile X Syndrome	8%
162	Child Nutrition Disorders	7.8%
163	Hypervitaminosis A	7.8%
164	Infant Nutrition Disorders	7.8%
165	Malnutrition	7.8%
166	Necrobiosis Lipoidica Diabeticorum	7.7%
167	Deformity	7.7%
168	Variegate Porphyria	7.6%
169	Acute intermittent porphyria	7.6%
170	Porphyria Cutanea Tarda	7.6%
171	Prader-Willi Syndrome	7.5%
172	Wernicke Encephalopathy	7.4%
173	Renal Osteodystrophy	7.3%
174	Renal rickets	7.3%
175	Familial Mediterranean Fever	7.3%
176	Dyslipidemias	7.3%
177	Autoimmune Lymphoproliferative Syndrome	7.2%
178	Kernicterus	7.2%
179	Smith-Magenis syndrome	7.1%
180	Cri-du-Chat Syndrome	7%
181	Down Syndrome	7%
182	Angioedemas, Hereditary	7%
183	Trisomy 21	7%
184	Acidosis, Respiratory	6.8%
185	Alkalosis, Respiratory	6.8%
186	Alstrom Syndrome	6.8%
187	Insulin Resistance	6.8%
188	Osteoporosis, Postmenopausal	6.8%
189	Marfan Syndrome	6.7%
190	Wiskott-Aldrich Syndrome	6.5%
191	Rett Syndrome	6.4%
192	Kartagener Syndrome	6.4%
193	Holoprosencephaly	6.2%
194	Fetal Diseases	6.2%
195	Ectodermal Dysplasia	6.2%
196	Aplasia Cutis Congenita	6.2%
197	Kallmann Syndrome	6%
198	Kearns-Sayre syndrome	5.9%
199	Myotonic Dystrophy	5.9%
200	Gestational Diabetes	5.8%
201	Latent Autoimmune Diabetes in Adults	5.8%
202	Diabetes Mellitus, Experimental	5.8%
203	Nephrocalcinosis	5.7%
204	Tetany	5.7%
205	Cerebral Amyloid Angiopathy	5.6%
206	Polycystic Kidney Diseases	5.6%
207	Williams Syndrome	5.6%
208	Rubinstein-Taybi Syndrome	5.5%
209	Sickle Cell Trait	5.5%
210	Tuberous Sclerosis	5.4%
211	Primary Ciliary Dyskinesia	5.4%
212	Retinal Dysplasia	5.1%
213	Aniridia	5%
214	Cutis Laxa	5%
215	Retinitis Pigmentosa	4.9%
216	Pigmentary retinopathy	4.9%
217	Epidermolysis Bullosa	4.9%
218	Porokeratosis	4.9%
219	Keratoderma, Palmoplantar	4.9%
220	Primary amyloidosis	4.9%
221	Chronic granulomatous disease	4.9%
222	Welander Distal Myopathy	4.8%
223	Hyperlipidemia, Familial Combined	4.8%
224	Deficiency Diseases	4.5%
225	Starvation	4.5%
226	Refeeding Syndrome	4.5%
227	Acute Chest Syndrome	4.4%
228	Duane Retraction Syndrome	4.3%
229	Amyotrophic Lateral Sclerosis	4.3%
230	Meconium Aspiration Syndrome	4.2%
231	Peutz-Jeghers Syndrome	4.2%
232	Myotonia Congenita	4.2%
233	Thrombasthenia	4.2%
234	Antithrombin III Deficiency	4.2%
235	Protein C Deficiency	4.2%
236	Afibrinogenemia	4.2%
237	Dystonia Musculorum Deformans	4.2%
238	Factor VII Deficiency	4.2%
239	Factor X Deficiency	4.2%
240	Factor XII Deficiency	4.2%
241	Hemophilia A	4.2%
242	Activated Protein C Resistance	4.2%
243	Factor II deficiency	4.2%
244	Factor VIII Deficiency	4.2%
245	Factor V deficiency	4.2%
246	Factor XI Deficiency	4.2%
247	Hypoprothrombinemias	4.2%
248	Lafora Disease	4.1%
249	Unverricht-Lundborg Syndrome	4.1%
250	Anemia, Diamond-Blackfan	4.1%
251	Abdominal Cramps	4.1%
252	Abnormalities, Drug-Induced	4.1%
253	Amniotic Band Syndrome	4.1%
254	Asphyxia Neonatorum	4.1%
255	Infant, Premature, Diseases	4.1%
256	Situs Inversus	4.1%
257	Infantile Colic	4.1%
258	Pseudoxanthoma Elasticum	4%
259	Multiple Endocrine Neoplasia	3.8%
260	Xeroderma	3.8%
261	Mobius Syndrome	3.8%
262	CREST Syndrome	3.8%
263	Congenital Hypothyroidism	3.7%
264	Dermatitis, Atopic	3.7%
265	Polycystic Kidney, Autosomal Dominant	3.7%
266	Classical Lissencephalies and Subcortical Band Heterotopias	3.5%
267	Eye Abnormalities	3.4%
268	Cardiovascular Abnormalities	3.4%
269	Frontotemporal dementia	3.4%
270	Hyperkeratosis, Epidermolytic	3.4%
271	Skin Abnormalities	3.3%
272	Lymphatic Abnormalities	3.3%
273	Congenital Microtia	3.3%
274	Anemia, Neonatal	3.3%
275	Persistent Fetal Circulation Syndrome	3.3%
276	Behcet Syndrome	3.3%
277	Congenital diaphragmatic hernia	3.3%
278	Umbilical hernia	3.3%
279	Basal Cell Nevus Syndrome	3.3%
280	Charcot-Marie-Tooth Disease	3.2%
281	Papillon-Lefevre Disease	3.2%
282	Huntington Disease	2.9%
283	Urogenital Abnormalities	2.9%
284	Neonatal Abstinence Syndrome	2.8%
285	Kwashiorkor	2.8%
286	Magnesium Deficiency	2.8%
287	Potassium Deficiency	2.8%
288	Protein Deficiency	2.8%
289	Avitaminosis	2.8%
290	Fetal Growth Retardation	2.8%
291	Fetal Hypoxia	2.7%
292	Congenital nystagmus	2.7%
293	Fetal Alcohol Spectrum Disorders	2.7%
294	Toxoplasmosis, Congenital	2.7%
295	Anencephaly	2.7%
296	Syphilis, Congenital	2.7%
297	Nephroblastoma	2.7%
298	Obesity	2.5%
299	Hydrops Fetalis	2.5%
300	Multiple Endocrine Neoplasia Type 1	2.4%
301	Prune Belly Syndrome	2.4%
302	Twins, Conjoined	2.4%
303	Waardenburg Syndrome	2.4%
304	Adenomatous Polyposis Coli	2.4%
305	Klinefelter Syndrome	2.4%
306	Chorioamnionitis	2.4%
307	Maxillofacial Abnormalities	2.4%
308	Dural Arteriovenous Fistula	2.4%
309	Dextrocardia	2.3%
310	Turner Syndrome	2.2%
311	Abnormalities, Radiation-Induced	2.1%
312	Ascorbic Acid Deficiency	2%
313	Vitamin A Deficiency	2%
314	Vitamin D Deficiency	2%
315	Vitamin E Deficiency	2%
316	Marasmus	2%
317	Anophthalmos	2%
318	Anus, Imperforate	2%
319	Hydranencephaly	2%
320	Microphthalmos	2%
321	Neural Tube Defects	2%
322	Paralysis, Obstetric	2%
323	Retinopathy of Prematurity	2%
324	Tethered Cord Syndrome	2%
325	Iniencephaly	2%
326	Craniorachischisis	2%
327	Limb Deformities, Congenital	2%
328	Exencephaly	2%
329	Septo-Optic Dysplasia	2%
330	Craniofacial Abnormalities	2%
331	Cortical Dysplasia	2%
332	Malformations of Cortical Development	2%
333	Anorectal Malformations	2%
334	Bronchopulmonary Dysplasia	1.9%
335	Scimitar Syndrome	1.9%
336	Obesity, Abdominal	1.9%
337	Ophthalmia Neonatorum	1.8%
338	Blepharophimosis	1.7%
339	Laryngostenosis	1.7%
340	Mouth Abnormalities	1.7%
341	Respiratory Distress Syndrome, Newborn	1.7%
342	Esophageal Atresia	1.7%
343	Intestinal Atresia	1.7%
344	Horseshoe Kidney	1.7%
345	Pectus excavatum	1.7%
346	Klippel-Feil Syndrome	1.6%
347	Gastroschisis	1.6%
348	Synostosis	1.6%
349	Acrodermatitis	1.6%
350	Lymphangiectasis, Intestinal	1.6%
351	Gianotti-Crosti Syndrome	1.6%
352	Craniosynostosis	1.6%
353	Syndactyly	1.6%
354	Brachycephaly	1.6%
355	Microcephaly	1.6%
356	Macrocephaly	1.6%
357	Denys-Drash Syndrome	1.6%
358	Folic Acid Deficiency	1.6%
359	Pellagra	1.6%
360	Thiamine Deficiency	1.6%
361	Vitamin B 12 Deficiency	1.6%
362	Vitamin B 6 Deficiency	1.6%
363	Pyridoxine Deficiency	1.6%
364	Pediatric Obesity	1.6%
365	Acrocephalosyndactylia	1.5%
366	Noonan Syndrome	1.5%
367	Arthrogryposis	1.4%
368	Choanal Atresia	1.4%
369	Tracheobronchomegaly	1.4%
370	Laryngocele	1.4%
371	Choledochal Cyst	1.4%
372	Hermaphroditism	1.4%
373	Disorders of Sex Development	1.4%
374	Cryptorchidism	1.4%
375	Hypospadias	1.4%
376	Central Nervous System Cysts	1.4%
377	Dandy-Walker Syndrome	1.4%
378	Beriberi	1.4%
379	Leukomalacia, Periventricular	1.4%
380	POEMS Syndrome	1.4%
381	Porencephaly	1.4%
382	Vitamin K Deficiency	1.4%
383	Amelia	1.3%
384	Arachnodactyly	1.3%
385	Ectopia Cordis	1.3%
386	Ectromelia	1.3%
387	Hemimelia	1.3%
388	Meningomyelocele	1.3%
389	Phocomelia	1.3%
390	Sirenomelia	1.3%
391	Spina Bifida	1.3%
392	Polydactyly	1.3%
393	Brachydactyly	1.3%
394	Plagiocephaly	1.3%
395	Lower Extremity Deformities, Congenital	1.3%
396	Upper Extremity Deformities, Congenital	1.3%
397	Single umbilical artery	1.3%
398	Cleft Palate	1.3%
399	Jaw Abnormalities	1.3%
400	Laryngomalacia	1.3%
401	Pectus carinatum	1.3%
402	Bladder Exstrophy	1.2%
403	Epispadias	1.2%
404	Multicystic Dysplastic Kidney	1.2%
405	Poland Syndrome	1.2%
406	Anemia, Pernicious	1.1%
407	Aortic coarctation	1.1%
408	Cor Triatriatum	1.1%
409	Coronary Vessel Anomalies	1.1%
410	Dental Enamel Hypoplasia	1.1%
411	Patent ductus arteriosus	1.1%
412	Ebstein Anomaly	1.1%
413	Heart Septal Defects	1.1%
414	Hyaline Membrane Disease	1.1%
415	Hypodontia	1.1%
416	Macrostomia	1.1%
417	Meningocele	1.1%
418	Microstomia	1.1%
419	Tetralogy of Fallot	1.1%
420	Transposition of Great Vessels	1.1%
421	Hypoplastic Left Heart Syndrome	1.1%
422	May-Thurner Syndrome	1.1%
423	Encephalocele	1.1%
424	Craniofacial Dysostosis	1.1%
425	Scurvy	1.1%
426	Wolff-Parkinson-White Syndrome	1.1%
427	Micrognathism	1%
428	Pierre Robin Syndrome	1%
429	Dermal Sinus	1%
430	Spina Bifida Cystica	1%
431	Spina Bifida Occulta	1%
432	Lissencephaly	1%
433	Polymicrogyria	1%
434	Pachygyria	1%
435	Schizencephaly	1%
436	Periventricular Nodular Heterotopia	1%
437	Long QT Syndrome	0.9%
438	Platybasia	0.9%
439	Tricuspid Atresia	0.9%
440	Arrhythmogenic Right Ventricular Dysplasia	0.9%
441	Gonadal Dysgenesis	0.9%
442	Bronchomalacia	0.9%
443	Adrenogenital Syndrome	0.9%
444	Tracheomalacia	0.9%
445	Ovotesticular Disorders of Sex Development	0.9%
446	Retrognathia	0.9%
447	Hyperandrogenism	0.9%
448	Prognathism	0.8%
449	Aortopulmonary Septal Defect	0.8%
450	Double Outlet Right Ventricle	0.8%
451	Endocardial Cushion Defects	0.8%
452	Myocardial bridging	0.8%
453	Aorticopulmonary Septal Defect	0.8%
454	Subacute Combined Degeneration	0.7%
455	Mandibulofacial Dysostosis	0.7%
456	Romano-Ward Syndrome	0.7%
457	Truncus Arteriosus, Persistent	0.7%
458	Goldenhar Syndrome	0.7%
459	Talipes	0.6%
460	Arteriovenous fistula	0.5%
461	Congenital clubfoot	0.5%
462	Vertical Talus	0.5%

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